Group based anonymity methods.
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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"7046",leadTitle:null,fullTitle:"Wound Healing - Current Perspectives",title:"Wound Healing",subtitle:"Current Perspectives",reviewType:"peer-reviewed",abstract:"Wound healing and its treatment are subjects that have been discussed for centuries in the medical literature. Wounds are everywhere, occurring in the young and elderly and in hospital and at home, and affect patients in every clinical specialty around the world. There are many publications on wound healing, but this book intends to give an overview of its current perspectives so as to be useful to practice care in wound healing and to improve the quality of life. It is considered that this book will be useful for clinicians who are interested in wound care.",isbn:"978-1-78985-538-8",printIsbn:"978-1-78985-537-1",pdfIsbn:"978-1-83880-645-3",doi:"10.5772/intechopen.73808",price:119,priceEur:129,priceUsd:155,slug:"wound-healing-current-perspectives",numberOfPages:260,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"fa7b870ad29ce1dfcf6faeafdc060309",bookSignature:"Kamil Hakan Dogan",publishedDate:"May 10th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/7046.jpg",numberOfDownloads:21119,numberOfWosCitations:37,numberOfCrossrefCitations:36,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:72,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:145,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 22nd 2018",dateEndSecondStepPublish:"May 16th 2018",dateEndThirdStepPublish:"July 15th 2018",dateEndFourthStepPublish:"October 3rd 2018",dateEndFifthStepPublish:"December 2nd 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"30612",title:"Prof.",name:"Kamil Hakan",middleName:null,surname:"Dogan",slug:"kamil-hakan-dogan",fullName:"Kamil Hakan Dogan",profilePictureURL:"https://mts.intechopen.com/storage/users/30612/images/system/30612.jpg",biography:"Kamil Hakan Dogan MD, PhD is a Full Professor and Chair in the Department of Forensic Medicine at Selcuk University, Faculty of Medicine in Turkey. Dr. Dogan received his MD from Gazi University, Faculty of Medicine in 2000. After his extensive research in the forensic medicine field, he received his PhD in Biochemistry in 2012. He gives lectures on Forensic Medicine and Medical Ethics to medical students as well as students of the dentistry and law faculties. He is the editor of five books and Bulletin of Legal Medicine, a reviewer for several international journals and he has published over 200 articles in refereed journals, chapters in textbooks and abstracts in scientific meetings. His publications have been cited more than 900 times.",institutionString:"Selçuk University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"Selçuk University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"994",title:"Traumatology",slug:"traumatology"}],chapters:[{id:"65588",title:"Introductory Chapter: An Overview of Wound Healing",doi:"10.5772/intechopen.84494",slug:"introductory-chapter-an-overview-of-wound-healing",totalDownloads:1233,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Kamil Hakan Dogan",downloadPdfUrl:"/chapter/pdf-download/65588",previewPdfUrl:"/chapter/pdf-preview/65588",authors:[{id:"30612",title:"Prof.",name:"Kamil Hakan",surname:"Dogan",slug:"kamil-hakan-dogan",fullName:"Kamil Hakan Dogan"}],corrections:null},{id:"64160",title:"Regulatory Mechanisms and Chemical Signaling of Mediators Involved in the Inflammatory Phase of Cutaneous Wound Healing",doi:"10.5772/intechopen.81731",slug:"regulatory-mechanisms-and-chemical-signaling-of-mediators-involved-in-the-inflammatory-phase-of-cuta",totalDownloads:1200,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Wound healing is a highly complex biological process composed of three overlapping phases: inflammatory, proliferative, and remodeling. The acute inflammatory response has being an integral role in tissue healing and fundamental for the homeostasis and reestablishment. This phase depends on the interaction of cytokines, growth factors, chemokines, and chemical mediators from cells to perform regulatory events and complex interactions of the extracellular matrix, extracellular molecules, soluble mediators, various resident cells such as fibroblasts and keratinocytes, and infiltrated leukocyte subtypes that act to restore or replace the integrity of the skin. If this well-orchestrated response becomes deregulated, the wound can become chronic or progressively fibrotic, with both outcomes impairing tissue function, which can ultimately lead to organ failure and death. In this chapter, we will review the pathway in the skin healing cascade, relating the major chemical inflammatory mediators, cellular and molecular, as well as demonstrating the local and systemic factors that interfere in healing and disorders associated with tissue repair deficiency in chronic inflammations, burns and hypertrophy.",signatures:"Fernando Pereira Beserra, Lucas Fernando Sérgio Gushiken, Maria\nFernanda Hussni and Cláudia Helena Pellizzon",downloadPdfUrl:"/chapter/pdf-download/64160",previewPdfUrl:"/chapter/pdf-preview/64160",authors:[{id:"256299",title:"Prof.",name:"Claudia",surname:"Pellizzon",slug:"claudia-pellizzon",fullName:"Claudia Pellizzon"},{id:"271401",title:"MSc.",name:"Fernando",surname:"Beserra",slug:"fernando-beserra",fullName:"Fernando Beserra"}],corrections:null},{id:"62998",title:"Biomarkers of Wound Healing",doi:"10.5772/intechopen.80222",slug:"biomarkers-of-wound-healing",totalDownloads:1656,totalCrossrefCites:3,totalDimensionsCites:3,hasAltmetrics:0,abstract:"The prevalence of conditions that eventually result in poor wound healing abounds as humans advance in age. With the increased possibility of wounds not healing comes a leap in morbidity and mortality with its accompanying socioeconomic impact. It is therefore relevant to understand what accounts for aberrant wound healing and more importantly the molecular markers involved in this pathological state. There are known events associated with the wound healing process, spanning from cellular involvement to the role of specific proteins such as cytokines and growth factors that are significant biomarkers in the wound healing process. This chapter discusses biomarkers relevant to the wound healing process, and these biomarkers go a long way to help identify and stratify nonhealing patients for whom biomarker-guided approaches may be of importance clinically in their management.",signatures:"Christian Agyare, Newman Osafo and Yaw Duah Boakye",downloadPdfUrl:"/chapter/pdf-download/62998",previewPdfUrl:"/chapter/pdf-preview/62998",authors:[{id:"182058",title:"Dr.",name:"Christian",surname:"Agyare",slug:"christian-agyare",fullName:"Christian Agyare"},{id:"196452",title:"Dr.",name:"Newman",surname:"Osafo",slug:"newman-osafo",fullName:"Newman Osafo"},{id:"252789",title:"Dr.",name:"Yaw Duah",surname:"Boakye",slug:"yaw-duah-boakye",fullName:"Yaw Duah Boakye"}],corrections:null},{id:"63086",title:"Medicinal Plants in Wound Healing",doi:"10.5772/intechopen.80215",slug:"medicinal-plants-in-wound-healing",totalDownloads:2846,totalCrossrefCites:7,totalDimensionsCites:13,hasAltmetrics:1,abstract:"Wound healing process is known as interdependent cellular and biochemical stages which are in trying to improve the wound. Wound healing can be defined as stages which is done by body and delayed in wound healing increases chance of microbial infection. Improved wound healing process can be performed by shortening the time needed for healing or lowering the inappropriate happens. The drugs were locally or systemically administrated in order to help wound healing. Antibiotics, antiseptics, desloughing agents, extracts, etc. have been used in order to wound healing. Some synthetic drugs are faced with limitations because of their side effects. Plants or combinations derived from plants are needed to investigate identify and formulate for treatment and management of wound healing. There is increasing interest to use the medicinal plants in wound healing because of lower side effects and management of wounds over the years. Studies have shown that medicinal plants improve wound healing in diabetic, infected and opened wounds. The different mechanisms have been reported to improve the wound healing by medicinal plants. In this chapter, some medicinal plants and the reported mechanisms will be discussed.",signatures:"Mohammad Reza Farahpour",downloadPdfUrl:"/chapter/pdf-download/63086",previewPdfUrl:"/chapter/pdf-preview/63086",authors:[{id:"253340",title:"Prof.",name:"Mohammadreza",surname:"Farahpour",slug:"mohammadreza-farahpour",fullName:"Mohammadreza Farahpour"}],corrections:null},{id:"63675",title:"Wound Healing: Contributions from Plant Secondary Metabolite Antioxidants",doi:"10.5772/intechopen.81208",slug:"wound-healing-contributions-from-plant-secondary-metabolite-antioxidants",totalDownloads:1309,totalCrossrefCites:7,totalDimensionsCites:20,hasAltmetrics:0,abstract:"Plants by their genetic makeup possess an innate ability to synthesize a wide variety of phytochemicals that help them to perform their normal physiological functions and/or to protect themselves from microbial pathogens and animal herbivores. The synthesis of these phytochemicals presents the plants their natural tendency to respond to environmental stress conditions. These phytochemicals are classified either as primary or secondary metabolites. The secondary metabolites have been identified in plants as alkaloids, terpenoids, phenolics, anthraquinones, and triterpenes. These plant-based compounds are believed to have diverse medicinal properties including antioxidant properties. Plants have therefore been a potential source of antioxidants which have received a great deal of attention since increased oxidative stress has been identified as a major causative factor in the development and progression of several life-threatening diseases, including neurodegenerative and cardiovascular diseases and wound infection. Consequently, many medicinal plants have been cited and known to effect wound healing and antioxidant properties. This chapter briefly reviews antioxidant properties of medicinal plants to highlight the important roles medicinal plants play in wound healing.",signatures:"Victor Y.A. Barku",downloadPdfUrl:"/chapter/pdf-download/63675",previewPdfUrl:"/chapter/pdf-preview/63675",authors:[{id:"261027",title:"Prof.",name:"Victor Y. A.",surname:"Barku",slug:"victor-y.-a.-barku",fullName:"Victor Y. A. Barku"}],corrections:null},{id:"63387",title:"The Strategies of Natural Polysaccharide in Wound Healing",doi:"10.5772/intechopen.80812",slug:"the-strategies-of-natural-polysaccharide-in-wound-healing",totalDownloads:1347,totalCrossrefCites:3,totalDimensionsCites:8,hasAltmetrics:1,abstract:"Severe or chronic wounds related to diseases or serious incidents have received big attention from not only a scientific standpoint but also a business perspective. Therefore, an effective treatment to abridge the long-term hospitalization of severe wound becomes indispensable. Glycosaminoglycan (GAG), one of the extracellular matrix molecules produced by fibroblasts, participates in cell-cell and cell-matrix interactions, in cell proliferation and migration, and in cytokine and growth factor signaling associated with all phases of wound recovery. Natural polysaccharide, for example, calcium alginate, which consists of mainly differing ratios of d-mannuronic and l-guluronic acid and rich of calcium ions, has been demonstrated to functionalize the glycosaminoglycan activity during wound healing. Once the trigger of the underlying wound healing mechanisms was understood, it should be possible to find ways to enhance and resolve the wound healing process in the patient with conditions and may lead to the potential for treatment alternatives in the future clinical field.",signatures:"Juin-Hong Cherng",downloadPdfUrl:"/chapter/pdf-download/63387",previewPdfUrl:"/chapter/pdf-preview/63387",authors:[{id:"252781",title:"Ph.D.",name:"Juin-Hong",surname:"Cherng",slug:"juin-hong-cherng",fullName:"Juin-Hong Cherng"}],corrections:null},{id:"66286",title:"From Tissue Repair to Tissue Regeneration",doi:"10.5772/intechopen.81291",slug:"from-tissue-repair-to-tissue-regeneration",totalDownloads:1909,totalCrossrefCites:4,totalDimensionsCites:5,hasAltmetrics:0,abstract:"In Regeneration 3.0, the priority is to combine the anti-inflammatory activity of the nine proteins acting as growth factors in the bovine colostrum, the homeostatic, angiogenic and reorganizational activities of the matrix, the modulation of collagen synthesis and the remodeling of the epithelium. The choice of bovine colostrum and its associated properties was the basis for the design of devices that could also offer those properties: barrier action, anti-inflammatory action and pain reduction, reduction and absorption of exudates, combating of bacterial and fungal proliferation, antioxidant action and hydration and protection against skin diseases and dermatosis. We now know the key players in the wound healing process and we have new molecules available to act on them, but the future must necessarily lie in the transfer of molecules and information between the endothelium, ECM and cell membrane, which can be directed toward tissue regeneration if the resident stem cells have the chance of communicating and interacting with new therapeutic models, all this without forgetting that the human being is at the center of research and scientific evolution.",signatures:"Aragona Salvatore Emanuele, Mereghetti Giada, Ferrari Alessio and\nGiorgio Ciprandi",downloadPdfUrl:"/chapter/pdf-download/66286",previewPdfUrl:"/chapter/pdf-preview/66286",authors:[{id:"247667",title:"Prof.",name:"Emanuele Salvatore",surname:"Aragona",slug:"emanuele-salvatore-aragona",fullName:"Emanuele Salvatore Aragona"}],corrections:null},{id:"64089",title:"Growth Hormone (GH) and Wound Healing",doi:"10.5772/intechopen.80978",slug:"growth-hormone-gh-and-wound-healing",totalDownloads:2256,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Wound healing is complex and numerous factors overlap perfectly with the goal of wound closure. Among them, we will focus on a large amount of experimental and clinical evidence on the action of GH in wound repair. We will analyze how the physiological rhythm of GH secretion influences this process, and also one of the most important signaling pathways that mediate the effects of GH on tissue regeneration. The role of IGF-1 and the factors that stimulate GH secretion and that have also been shown to improve healing will also be reviewed. In addition, it will be analyzed the cellular senescence process, which plays a key role in nonhealing wounds associated with chronic diseases. The benefit of GH in this last circumstance is especially important. The lesions associated with catabolic states, mainly burns, are considered a delicate situation in which it is extraordinarily difficult to act with growth factors due to the fragile situation of these patients, often children. The positive action of GH in these states will also be described. In summary, we will analyze many evidences about the beneficial effects of GH and its main secretagogues in the healing of wounds.",signatures:"Diego Caicedo and Jesús Devesa",downloadPdfUrl:"/chapter/pdf-download/64089",previewPdfUrl:"/chapter/pdf-preview/64089",authors:[{id:"221342",title:"Dr.",name:"Jesús",surname:"Devesa",slug:"jesus-devesa",fullName:"Jesús Devesa"},{id:"257224",title:"Dr.",name:"Diego",surname:"Caicedo Valdes",slug:"diego-caicedo-valdes",fullName:"Diego Caicedo Valdes"}],corrections:null},{id:"63308",title:"Autologous Platelet-Rich Plasma and Mesenchymal Stem Cells for the Treatment of Chronic Wounds",doi:"10.5772/intechopen.80502",slug:"autologous-platelet-rich-plasma-and-mesenchymal-stem-cells-for-the-treatment-of-chronic-wounds",totalDownloads:1816,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:1,abstract:"Emerging autologous cellular therapies, utilizing platelet-rich plasma and mesenchymal stem cell applications, have the potential to play an adjunctive role in a standardized wound care treatment plan in patients suffering from chronic and recalcitrant wounds. The use of platelet-rich plasma growth is based on the fact that platelet growth factors can support the three phases of wound healing and then ultimately contribute to full wound closure. Mesenchymal stem cell-based therapies are also an attractive approach for the treatment of these difficult-to-heal wounds. This field of regenerative medicine focuses primarily on stem cells, which are specialized cells with the ability to self-renew and differentiate into multiple cell types. Mesenchymal stem cells can be isolated from bone marrow and adipose tissue via minimally manipulative and cell-processing techniques, at point of care. Both platelet-rich plasma and mesenchymal stem cell applications have the potential to become an effective and ideal autologous biological cell-based therapy, which can be applied to chronic wounds to effectively change the wound bed microenvironment to enable and accelerate wound closure.",signatures:"Peter A. Everts",downloadPdfUrl:"/chapter/pdf-download/63308",previewPdfUrl:"/chapter/pdf-preview/63308",authors:[{id:"256306",title:"Ph.D.",name:"Peter A.",surname:"Everts",slug:"peter-a.-everts",fullName:"Peter A. Everts"}],corrections:null},{id:"64239",title:"The Wound Healing Responses and Corneal Biomechanics after Keratorefractive Surgery",doi:"10.5772/intechopen.81886",slug:"the-wound-healing-responses-and-corneal-biomechanics-after-keratorefractive-surgery",totalDownloads:868,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Corneal biomechanics have been concerned recently since it is not only found to play an important role in the wound healing process after corneal refractive surgeries, but also essential to improve the predictability and safety of refractive procedures. Corneal biomechanics and wound healing responses are linked in time and space and may also cause complications of keratectasia, haze formation, and regression. This review focuses on wound healing and biomechanics of the corneal refractive procedures. Identifying corneal wound healing from the biomechanical point of view is mandatory to improve the outcomes and reduce the complications.",signatures:"Wenjing Wu and Yan Wang",downloadPdfUrl:"/chapter/pdf-download/64239",previewPdfUrl:"/chapter/pdf-preview/64239",authors:[{id:"259430",title:"Prof.",name:"Yan",surname:"Wang",slug:"yan-wang",fullName:"Yan Wang"},{id:"268031",title:"Dr.",name:"Wenjing",surname:"Wu",slug:"wenjing-wu",fullName:"Wenjing Wu"}],corrections:null},{id:"64137",title:"Open Abdomen: The Surgeons’ Challenge",doi:"10.5772/intechopen.81428",slug:"open-abdomen-the-surgeons-challenge",totalDownloads:1146,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"An open abdomen is defined as purposely foregoing fascial closure of the abdomen after the cavity is opened. Management of complex abdominal problems with the open abdomen and temporary abdominal closure techniques has become a common and valuable tool in surgery. Several challenging clinical situations can necessitate leaving the abdominal cavity open after surgery, resulting in an open abdomen. The indications for open abdomen are as follows: Damage control for life-threatening intraabdominal bleeding, severe acute pancreatitis, severe abdominal sepsis, and prevention and treatment of the abdominal compartment syndrome. Damage control surgery is based on a rapid control of bleeding and focuses on reversing physiologic exhaustion in a critically ill or injured patient. In severe abdominal sepsis, the intervention should be abbreviated due to suboptimal local conditions for healing and global susceptibility to spiraling organ failure. Abdominal compartment syndrome (ACS) is commonly encountered and the only solution is decreasing the pressure by decompressive laparotomy. Open abdomen is associated with significant complications, including wound infection, fluid and protein loss, a catabolic state, loss of abdominal wall domain, and development of enteroatmospheric fistula; however, if the indications are clear, it can become a most valuable resource in treating these conditions.",signatures:"Juan José Santivañez Palominos, Vergara Arturo and Cadena Manuel",downloadPdfUrl:"/chapter/pdf-download/64137",previewPdfUrl:"/chapter/pdf-preview/64137",authors:[{id:"257817",title:"Prof.",name:"Manuel",surname:"Cadena",slug:"manuel-cadena",fullName:"Manuel Cadena"}],corrections:[{id:"67216",title:"Corrigendum to: Open Abdomen: The Surgeons’ Challenge",doi:null,slug:"corrigendum-to-open-abdomen-the-surgeons-challenge",totalDownloads:null,totalCrossrefCites:null,correctionPdfUrl:null}]},{id:"65565",title:"Facilitation of Wound Healing Following Laparoscopic and Conventional Abdominal Surgery with Dressings, Patches, Antibiotics, etc.",doi:"10.5772/intechopen.82614",slug:"facilitation-of-wound-healing-following-laparoscopic-and-conventional-abdominal-surgery-with-dressin",totalDownloads:1134,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Wounds due to surgical incisions and due to injuries often do not heal and can result in complications like slow healing and infections. Several approaches to facilitate wound healing are constantly being developed. Here we discuss various wounds and multiple ways to treat wounds especially those resulting from abdominal surgery either due to conventional surgery or due to laparoscopic surgery. In future, there are various possibilities in the pipeline that could result in accelerated wound healing as well as tissue regeneration.",signatures:"Rebekah Amarini, Sufan Chien and Girish J. Kotwal",downloadPdfUrl:"/chapter/pdf-download/65565",previewPdfUrl:"/chapter/pdf-preview/65565",authors:[{id:"256106",title:"Prof.",name:"Girish",surname:"Kotwal",slug:"girish-kotwal",fullName:"Girish Kotwal"},{id:"256112",title:"Prof.",name:"Sufan",surname:"Chien",slug:"sufan-chien",fullName:"Sufan Chien"},{id:"259039",title:"Dr.",name:"Rebekah",surname:"Amarini",slug:"rebekah-amarini",fullName:"Rebekah Amarini"}],corrections:null},{id:"64531",title:"Multidisciplinary Approaches to the Stimulation of Wound Healing and Use of Dermal Substitutes in Chronic Phlebostatic Ulcers",doi:"10.5772/intechopen.81791",slug:"multidisciplinary-approaches-to-the-stimulation-of-wound-healing-and-use-of-dermal-substitutes-in-ch",totalDownloads:997,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Research focus: Skin injuries are evolving as an epidemic issue. Chronic skin lesion is a globally widespread disease, often referred to as a “wound difficult to heal” and one which has a strong impact on both overall health and quality of life. Genetic and clinical variables, such as diabetes, smoking and inflammatory/immunological pathologies, are among the important risk factors limiting the regenerative powers of many therapeutic applications. Therefore, optimisation of current clinical strategies is critical. Experimental research: Here we summarise the field’s current state by focusing on the use of stem-cell therapeutic applications in wound healing, placing considerable emphasis on current clinical approaches being developed at Rome’s Sapienza University. These involve protocols for the ex vivo expansion of adipose tissue-derived mesenchyme stem cells using a patented GMP-compliant platelet lysate, Mesengen™, and cellular and acellular dermal substitutes. A combination of multiple strategies, including genetic modifications of stem cells, biomimetic scaffolds or novel vehicles like nanoparticles, is also discussed as future approaches. Case studies: Here we present a report portraying our clinical experience of the treatment of chronic phlebostatic ulcers. The aim of the study reported here was to evaluate the effectiveness of treatment with dermal substitutes of cutaneous lesions originating from chronic venous insufficiency, therapy which took into consideration parameters such as the reduction of wound size and the improvement of quality of life. Chronic skin lesion, a globally widespread disease, is often referred to as a “difficult wound” and has a strong impact on both overall health and quality of life. The difficulties encountered when seeking to heal this ailment have led to a quest for and development of new therapeutic approaches, including dermal substitutes. We can subdivide these into acellular matrices, such as Integra and Hyalomatrix, and cell therapies such as platelet concentrate and mesenchyme cell concentrate. Results: In all the patients treated, elements of improvement were observed: the appearance on the wound bed of small islands of granulation tissue, superficialization of the bottom of the ulcer and a growth of marginal tissue. During the first 30 days, a reduction in more than 25% of the area of the lesion and a reduction in more than 50% at the end of the observation period were recorded in 10 of the patients who underwent preliminary surgical treatment out of the 13 subjects included in the study sample. On the whole, at the end of the observation period, we witnessed an average 57% decrease in the lesion in all the patients; furthermore, during the treatment period, there was a gradual reduction in pain, measured using the NRS numerical scale. An overall average reduction in pain of four points on the NRS numerical scale was achieved. At the end of the 8-week evaluation period, the majority of the patients reported an improvement in the quality of their lives, since, in addition to the reduction of spontaneous pain, there was a diminution of pruritus, secretions—often malodorous and capable of affecting social life negatively—with recovery of functional capacity and almost complete recovery of habitual daily activities. During the period of treatment, no superinfections of the wounds or secondary complications related to the use of the various products were detected. Main conclusions: The numerous technological opportunities provided by regenerative medicine—including advanced dressings and dermal substitutes—if applied correctly, in compliance with a multidisciplinary approach where necessary, seem to offer advantages not only in terms of clinical efficacy and patient life quality but also in terms, it would appear, of healthcare costs, an aspect which should not be either overlooked or underestimated.",signatures:"Raffaele Capoano, Rita Businaro, Besar Kolce, Andrea Biancucci,\nSilvia Izzo, Lidia De Felice and Bruno Salvati",downloadPdfUrl:"/chapter/pdf-download/64531",previewPdfUrl:"/chapter/pdf-preview/64531",authors:[{id:"268270",title:"Prof.",name:"Raffaele",surname:"Capoano",slug:"raffaele-capoano",fullName:"Raffaele Capoano"}],corrections:null},{id:"66793",title:"The Impact of Biofilm Formation on Wound Healing",doi:"10.5772/intechopen.85020",slug:"the-impact-of-biofilm-formation-on-wound-healing",totalDownloads:1407,totalCrossrefCites:7,totalDimensionsCites:15,hasAltmetrics:0,abstract:"Chronic wounds represent an important challenge for wound care and are universally colonized by bacteria. These bacteria can form biofilm as a survival mechanism that confers the ability to resist environmental stressors and antimicrobials due to a variety of reasons, including low metabolic activity. Additionally, the exopolymeric substance (EPS) contained in biofilm acts as a mechanical barrier to immune system cells, leading to collateral damage in the surrounding tissue as well as chronic inflammation, which eventually will delay healing of the wound. This chapter will discuss current knowledge on biofilm formation, its presence in acute and chronic wounds, how biofilm affects antibiotic resistance and tolerance, as well as the wound healing process. We will also discuss proposed methods to eliminate biofilm and improve wound healing despite its presence, including basic science and clinical studies regarding these matters.",signatures:"Rafael A. Mendoza, Ji-Cheng Hsieh and Robert D. Galiano",downloadPdfUrl:"/chapter/pdf-download/66793",previewPdfUrl:"/chapter/pdf-preview/66793",authors:[{id:"253607",title:"M.D.",name:"Rafael",surname:"Mendoza",slug:"rafael-mendoza",fullName:"Rafael Mendoza"},{id:"254018",title:"Dr.",name:"Robert",surname:"Galiano",slug:"robert-galiano",fullName:"Robert Galiano"},{id:"271116",title:"Mr.",name:"Ji-Cheng",surname:"Hsieh",slug:"ji-cheng-hsieh",fullName:"Ji-Cheng Hsieh"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6262",title:"Post Mortem Examination and Autopsy",subtitle:"Current Issues From Death to Laboratory Analysis",isOpenForSubmission:!1,hash:"fce869ae396986e202a78883a0b1045f",slug:"post-mortem-examination-and-autopsy-current-issues-from-death-to-laboratory-analysis",bookSignature:"Kamil Hakan Dogan",coverURL:"https://cdn.intechopen.com/books/images_new/6262.jpg",editedByType:"Edited 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Information-psychological impact (IPI) is the informational influence on people’s minds, which alters their perception of the reality, behavioural functions and, in some cases, even the functioning of their inner organs and body systems [1, 2, 3]. Information-psychological impact (IPI) may affect individuals, groups of people, communities and the whole society. IPI can be either positive or negative, depending on the intended purpose. Positive IPI is used for medical treatment purposes, rehabilitation, improvement of behavioural patterns and creative purposes. It can also be used to unite people for a good cause. Negative IPI is used for manipulating—directly or indirectly—individuals, groups of people or the whole society into actions that violate either their own interests or interests of others. Negative IPI may cause emotional, psychological and social tensions, deterioration of moral standards and behavioural norms, as well as moral and political disorientation. This, in turn, leads to dramatic changes in individual, group and public conscience and alterations in the moral, political, social and psychological environment within the society [1, 2, 3].
\nInformation-psychological impact is implemented by means of various tools and techniques. At the moment, negative information-psychological impacts are more common. They influence individuals, groups of people or the society by means of telecommunication systems, mass media and social networks. Negative IPIs are used to control the society, force certain opinions on various issues, recruit members to religious cults and terrorist groups and to alter people’s mental state. Among the examples of such IPIs are colour revolutions, the so-called “death groups” on social networking sites, as well as active recruitment campaigns to terrorist groups, which are based on films or video games aimed primarily at young people.
\nIt is thus very important to model IPIs in social networks in order to analyse and select the most effective methods of using positive IPIs and combating negative IPIs [1, 2, 4].
\nSocial networks are usually represented as graphs with multiple vertices (agents) and edges representing the links between the agents. Agents represent various subjects of the network, from individuals to large groups, organisations and communities. Links denote the relationships between the agents, such as information exchange, social relations and communication [4, 5, 6, 7, 8, 9]. The process of IPI can be divided into two stages: diffusion of the IPI and alteration of the agents’ opinions. Gubanov et al. [4] consider various models of social networks and divide the tasks connected with studying IPI into following groups: modelling of the informational influence, modelling of the information management and modelling of the information confrontation.
\nModels of the informational influence are used to study the behaviour of the subject affected by IPI. The influence may be intentional or unintentional. Social influence becomes obvious during communication or in case of comparison. Models of the informational influence are used for information management, as they help the managing subject to determine the kind of informational influence that will make the controlled subject behave in the desired way. The information management model, in turn, is used to model information confrontation, that is, the interaction of several subjects with conflicting interests who apply their informational influence to the same controlled subject [4]. There are a number of approaches to modelling the influence.
The Independent Cascade and Linear Threshold Models [4, 8, 10, 11, 12, 13]. In these models, the subject (a vertice of the graph) can be either active or inactive. The state may only change from active to inactive, not the other way round. The agent becomes active depending on the selected threshold. The threshold can be uniform for all agents or may be randomly selected according to a probabilistic distribution. These models do not take into account groups, game interaction between the subjects, individual activity of the subjects or incomplete awareness of the subjects.
Network autocorrelation models. In these models, the opinion and behaviour of the subject are affected by the opinion of the neighbouring subjects and represent the reaction of the subject to the IPI. The authors [14, 15, 16, 17, 18, 19] consider a determined time-digital linear process, where opinions (properties) of the subject are presented as vector \n
Ising models [20, 21]. Invented for studying the phenomenon of ferromagnetism, Ising model is often used to verify the results of numerical modelling. When studying the diffusion of IPI in social networks, the model helps to describe the changes in the behaviour of a large social group caused by the nearest neighbours. The influence of the nearest neighbours plays a key role, and the willingness of the group to accept a new idea serves as the analogue of the temperature.
Influence models based on Markov chains. Such models employ corresponding mathematical tools to represent the activities of every subject and the group as a whole. They are used to analyse social dynamics and determine the patterns of the group behaviour. The authors [22, 23, 24] consider the similarity of opinions of the subject, the authors [7, 24] focus on the time over which the opinions become similar, and the authors [7, 25] study the conditions under which a uniform final opinion is formed.
All the above-mentioned models represent the rules of interaction between the subjects or groups of subjects. However, they either do not at all represent the specifics and characteristics of the network influence and the interaction process or do this inadequately.
\nWhen a social network is considered as a set of agents [4, 26, 27, 28], we assume that every agent has a certain degree of influence on the other agents. It is therefore necessary to determine a small group of agents with the maximal level of influence, that is, to solve the influence maximisation problem [4, 10, 29]. These agents can be used as key nods for influencing other subjects of the social network or to monitor the social network in order to reveal the presence of IPI. The influence maximisation problem has been considered in papers focusing on the following issues.
Viral marketing [29], where a social network is represented by a Markov chain with each agent A having his own value that depends on the profit from sales to other agents influenced by agent A.
Influence maximisation in the models of innovations’ diffusion [10]. They include a set of active agents, and at a certain point in time, a new active agent can activate his neighbours with a set probability.
Voting process modelling [9], where every agent can, at any stage, change his opinion by accidentally voting for one of his neighbours and adapting their opinion. The agent is more likely to adapt the opinion supported by the majority of his neighbours.
Besides analysing the influence, management and confrontation, there is also a problem of diffusion of information-psychological impact in the information space [5]. Information may spread in the following directions [5, 30]: from a subject to another subject, from a subject to a group, from the information production centre to an individual subject or a group.
\nThe authors [5, 26, 27, 28, 31] suggest a multi-agent model of information diffusion. The model takes into account the growth of the number of agents over time. Agents may appear themselves, produce new agents, disappear from the subjects’ neighbourhood or receive links from other agents.
\nIn [5, 30], the life cycle of the information flow is represented by information diffusion models based on cellular automata. In these models, each cell of the automaton can have various states, such as “influence taken,” “influence not relevant,” or “influence rejected.” The information spreads according to probabilistic rules. The observed states of the objects alter simultaneously in discrete time intervals following the constant local probabilistic rules. The rules themselves depend on the state of variables describing the nearest neighbours of the agent or on the state of the subject itself. For instance, the authors [8, 32] present a model of word-of-mouth information transfer considering strong and weak links between the subjects.
\nIn order to analyse the information diffusion process, the authors [6, 33, 34] compare information diffusion to virus transmission using infiltration and contamination models such as SIR model and SIRS model.
\nRunkov [35] compares the structure of social networks and neural networks. Individual users are viewed as neurons. Using the information about the users’ activities, the neural network may forecast the kind of news they will be interested in [35, 36] also suggests using neural networks to forecast the behaviour of the subject of IPI and their recruitability to certain assignments, as well as to assess their reliability using the data available in the social network.
\nFrom the information security perspective, it is vital to identify IPI as soon as possible. For this purpose, the authors [4, 37] suggest monitoring the states of a small group of nods in the network using graph models. The problem is to determine the set of nods to be monitored. Deviations from the standard dynamics of transmission of some information messages may serve as an indicator of information-psychological impact. In order to analyse the dynamics of the information spread and determine the channels caused by external factors, wavelet analysis can be used [5, 15, 17].
\nDodonov and Lande [5] introduce the term information reservation for an isolated area of the information space and suggest certain modification to information diffusion models in order to model the dynamics of information flows in information reservations. Information reservations are information areas subject to constant information-psychological impact. They can be used for information and psychological control over the society.
\nWe should say, however, that all the suggested models do not fully consider social and psychological factors, such as the psychological state of the subjects during IPI diffusion in social networks. IPI diffusion process depends on the probabilistic characteristics of the subjects of the social network and the links between them. It is, therefore, interesting to study IPI diffusion taking into account social and psychological factors and the psychological state of the subjects of the social network.
\nThe aim of this paper is to model the process of IPI diffusion in social networks considering social and psychological factors and the psychological state of the subjects of the social network. This can be done using a cellular automaton model, as cellular automata can most adequately represent the process of IPI diffusion in a social network and the changes in the opinions of its subjects caused by their immediate neighbours, taking into account social and psychological factors.
\nWhen modelling and analysing the process of IPI diffusion, we regarded the social network as a two-dimensional cellular automaton. A two-dimensional cellular automaton is a set of finite automata (subjects of the social network) allocated on the reference frame and marked with integer coordinates \n
where \n
In the cellular automaton model, each cell changes its state while interacting with a limited number of other cells, normally adjacent ones with the same edge or vertex. Such models allow for a simultaneous change of the state of all cells following the general principle of the cellular automaton. Therefore, it is easy to see the connection between the processes occurring on the micro level and the processes of spatial interaction between the elements.
\nDue to the simplicity of their implementation and the ability to describe complex processes, cellular automata are widely used for the modelling of systems, which consist of a large number of nonlineary interacting particles (fluid and gas dynamics in various environments, fires, traffic, and so on), as well as for representing collective phenomena, such as turbulence, arrangement and chaos.
\nGiven below are the models we suggest for describing the process of information-psychological impact diffusion in social networks.
Information interaction within the social network is presented as a two-dimensional cellular automaton, whose grid is a two-dimensional array, where each cell is numbered with an ordered pair \n
The informational interaction in the social network is presented as a cellular automaton, whose grid is a free-scale network generated by a Barabási-Albert algorithm.
Each cell may be in one of the following states: highly positive, neutral (mild negative or positive attitude) or highly negative. Depending on its state and social and psychological characteristics, a cell may or may not spread the information (by influencing the neighbouring cells) [5, 30, 38]. The state and behaviour of cells change according to the set of rules for the suggested model. These rules take into account social and psychological factors as well as the psychological state of the subjects of the social network.
\nA state transition graph is presented in Figure 1. \n
State transition graph.
Each subject \n
Initial personal opinion \n
[−1; −0.64) interval—highly negative opinion that motivates the subject to spread the information \n
[−0.64; 0) interval—mild negative opinion that does not motivate the subject to spread the information \n
[0; 0.64) interval—mild positive opinion that does not motivate the subject to spread the information \n
[0.64; 1) interval—highly positive opinion that motivates the subject to spread the information \n
Level of trust \n
Communication skills \n
Information transfer coefficient \n
Level of perception \n
In order to evaluate the current (at a specific time interval \n
where \n
Whether subject \n
The subject affected by the IPI in the social network develops his own opinion about the received information, which depends on his individual parameters and the force of the IPI. The opinion can be positive or negative and may change over time under the influence of other factors. Depending on his opinion about the information and his communication skills, the subject may or may not spread the received IPI [43, 44, 45, 46].
\nThe effectiveness of the IPI can be defined by the following relation Eq. (4):
\nwhere \n
Users of the social network may be subject to various kinds of IPI aimed at different groups of people. IPIs may also differ by their purpose and the effectiveness of implementation. IPI in social networks may also be used to influence specific public officers.
\nUsing the results of the IPI modelling, we can perform a comprehensive assessment of the general level of information and psychological security and suggest practical recommendations on how to eliminate the negative effect of the information-psychological influence. The assessment can be based on the methodology for calculating the security indices in the military, political, economic and other spheres developed by the PIR Center [48, 49]. This means that the index of general information and psychological security (IGIPS) is calculated according to the following formula:
\nwhere \n
\n\n
where \n
The probability of the IPI being aimed at a specific public officer is calculated using Eq. (7) [2]:
\nwhere \n
The suggested method of assessing the IGIPS has the following advantages. It registers the increase in the degree of the IPI on the social network in good time. It registers the connection between the IPI on public officials and the decisions they make. It allows for calculating the index of information and psychological security and developing a strategy to decrease negative IPIs.
\n\nFigure 2 presents a flow chart of the algorithm for modelling IPI. During the initial stage, main parameters of the social network’s subjects are determined. The trust matrix is formed, and the communication skills of the subjects, their perception level, information transfer coefficient and the initial opinion about the given issue are determined [43, 44, 45, 46, 47].
\nFlow chart of the algorithm for modelling IPI.
During the first stage, which corresponds to the origin on the time axis \n
The second stage involves information diffusion and exchange of opinions between the subjects along the time axis \n
A cell may change its state receiving influence \n
The suggested algorithm was implemented on a 100 × 100 grid. The automaton was tested in the following way: the initial values were distributed following the normal distribution law; 10 random initiators of the IPI and 2 opponents were selected out of all the subjects; the automaton was tested 100 times, each test run including 1000 steps; average number of subjects in each of the states was determined. The initial personal opinion of subject \n
Distribution of cells according to the discrete time whenever
Distribution of cells according to the discrete time whenever
Distribution of cells according to the discrete time whenever
\nFigure 4 demonstrates the functioning of the automaton, when \n
Random scale-free network generated by Barabási-Albert model.
The suggested algorithm was implemented using a random scale-free network generated by Barabási-Albert algorithm. The network consisted of 1000 nods. The results are given in Figure 6. The automaton was tested in the following way: the initial values were distributed following the normal distribution law; 90 random initiators of the IPI and 10 opponents were selected out of all the subjects; the automaton was tested 100 times, each test run including 300 steps; average number of subjects in each of the states was determined. The initial personal opinion of the subject \n
Distribution of cells according to the discrete time whenever
Distribution of cells according to the discrete time whenever
Distribution of cells according to the discrete time whenever
\nFigure 7 demonstrates the functioning of the automaton, when \n
Analysis of Figures 3–9 shows that
the character of the IPI diffusion within the social network is practically exponential;
when the subjects are neutral to the IPI (Figures 3a and 7a), just a small number of initiators can successfully perform the IPI;
when the subjects are negative or positive to the IPI (Figures 4a, 5a, 8a, and 9a), the IPI does not influence their state;
when the subjects do not trust each other and change their opinions to the opposite ones (Figures 3–5b and 7–9b), the number of subjects in states S3 and S4 is similar, irrespective of their initial state.
The results obtained using the suggested models agree with the results presented in Refs. [4, 5, 30]. These works consider the information diffusion, which is an individual case of IPI diffusion in social networks. As opposed to Refs. [4, 5, 30, 39, 40], the suggested model is not based on the probabilistic characteristics of the subjects of the social network but takes into account the social and psychological parameters of the subjects and their psychological state during IPI diffusion in social networks.
\nThe paper suggests a model for describing the diffusion process of information-psychological impact in social networks based on cellular automata. Cellular automata models can change the states of a large number of cells over a minimal period of time, which is very useful for the modelling of the process of information-psychological impact diffusion in social networks. The suggested models can thus represent the process of IPI diffusion in a social network and the corresponding changes in the opinions of its subjects caused by their immediate neighbours, taking into account social and psychological factors.
\nEspecially with the 2019 pandemic, in today’s world where business and education life is done electronically over the internet, fast and voluminous data sharing is made with the undeniable effect of social media and unfortunately technology works against privacy. The rapid widespread use of data mining techniques in areas such as medicine, sports, marketing, signal processing has also increased the interest in privacy. The important point here is to define the boundaries of the concept of privacy and to provide a clear definition. Individuals define privacy with the phrase “keep information about me from being available to others”. However, when it comes to using these personal data in a study that is considered to be well intentioned, individuals are not disturbed by this situation and do not think that their privacy is violated [1]. What is missed here is the difficulty of preventing abuse once the information is released.
Personal data is information that relates to an identified or identifiable individual. This concept consists of the components that the data pertain to a person and that this person can also be identified. Personal data is a concept that belongs to the “ego” and is handled in a wide range from names to preferences, feelings and thoughts. An identifiable person is someone who can be identified directly or indirectly, in particular by reference to an identification number or one or more factors specific to their physical, physiological, mental, economic, cultural or social identity. For this reason, the loss of the individual’s control authority over these data brings about the loss of the individual’s freedom, autonomy, privacy, in short, the property of being me. The main way to ensure the use of these data without harming the privacy of individuals is to remove the identifiability of the person.
Data analysis methods, including data mining, commodify data and turn it into economic value. Apart from the ethical debates about this, it is an undeniable fact that the digital environment increases the risk of losing control of all information about one’s own intellectual, emotional and situational, in short, losing its autonomy and violating the informational privacy area. The main dilemma here is; the freedom in the flow of information provided by technology, the interest relationships it provides and the benefit provided by the information source is the control power required by the concept of being an individual [2].
In addition, legal regulations aiming to protect personal data are made by governments, including for what purpose (historical, statistical, commercial, scientific) data is used, how it is collected and how it should be stored. For example, the US HIPAA rules aim to protect individually identifiable health information. These are information that is a subset of health information, including demographic information collected from an individual [3]. In the EC95/46 [4] directive, the European parliament and of the council allow the use of personal data in the case of (i) if the data subject has explicitly given his permission, or (ii) the need for a result requested by the individual. This also applies to corporate privacy issues. Privacy concerns bring corporate privacy concerns with them. However, corporate privacy and individual privacy issues are not much different from each other. The disclosure of information about an organization can be considered a potential privacy breach. In this case, it involves both views to generalize to disclosure of information about a subset of data.
The point to note here is that while focusing on the disclosure of data subjects, the secrets of the data providers’ organization should also be taken into account. For example, considering that data mining studies were carried out on student data of more than one university in an academic study. Although the methods used protect the privacy of the student, certain information that is specific to the university and they want to keep may be revealed. Although the personal data owned by the organizations are secured by contracts and legal regulations, information about a subset of the combined data set may reveal the identity of the data subject. The organization that owns the data set must be involved in a distributed data mining process as long as it can prevent the disclosure of the data subjects it provides and its own trade secrets.
In the literature, solutions that take data privacy into account have been proposed in data mining. A solution that ensures that no individual data is exposed can still publish information that describes the collection as a whole. This type of corporate information is often the purpose of data mining, but some results can be identified, various data hiding and suppression techniques have been developed to ensure that the data are not individually identified.
The concept of privacy can be examined under three headings as “physical–physical, mental-communicative and data privacy [5]. The main subject in this study is data privacy.
Data privacy can be defined as the protection of real persons, institutions and organizations (Data Subject) that need to be protected in accordance with the law and ethical rules during the life cycle of data (collecting data, processing and analyzing data, publishing and sharing data, preserving data, re-use data) [6]. In this process, for what purpose the data will be processed, with whom it will be shared, where it will be transferred, and being able to be controlled by the data subject at a transparent and controllable level are important requirements of data privacy. On the other hand, there is no exact definition of privacy, the definition can be made specific to the application.
Data controllers who need to take privacy precautions in order to prevent data breaches are assumed to be reliable and have legal obligations; stores and uses the data collected with digital applications using appropriate methods, and shares them by anonymizing when necessary. Collected data are classified into four groups [7];
Identifiers (ID): It contains information that uniquely and directly identifies individuals such as full name and social security number.
Quasi-identifiers (QID): Identifiers that, combined with external data, lead to the indirect identification of an individual. These attributes are non-unique data such as gender, age, and postal code.
Sensitive attributes (SA): It contains data that is private and sensitive to individuals, such as sickness and salary.
Insensitive attributes: It contains general and non-risky data that are not covered by other attributes.
It is not sufficient to measure privacy with a single metric because different definitions can be made for different applications and multiple parameters must be evaluated for this purpose. It is possible to examine the proposed metrics for PPDMs [8, 9] as privacy level metric and data quality metric, depending on which aspect of privacy is measured. While evaluating these metrics, they can be measured in two subgroups to evaluate the level of privacy/data quality on the input data (data criteria) and data mining results (result criteria). How secure the data is in terms of disclosure is measured by the level of privacy metrics [10]:
Privacy Protected Data Mining (PPDM) techniques have been developed to allow the extraction of information from data sets while preventing the disclosure of data subjects’ identities or sensitive information. In addition, PPDM allows more than one researcher to collaborate on a dataset [11, 12]. Also PPDM can be defined as performing data mining on data sets to be obtained from databases containing sensitive and confidential information in a multilateral environment without disclosing the data of each party to other parties [13].
In order to protect privacy in data mining, statistical and cryptographic based approaches have been proposed. The vast majority of these approaches operate on original data to protect privacy. This is referred to as the natural trade-off between data quality and privacy level.
PPDM methods are being studied on to perform effective data mining by guaranteeing a certain level of privacy. Several different taxonomies have been proposed for these methods. In the literature, based on data life cycle stages (data collection, data publishing, data distribution and output of data mining) [10] or they are classified based on the method used (Anonymization based, Perturbation based, Randomization based, Condensation based and Cryptography based) [14].
In this study, PPDM approaches are examined with a simple taxonomy as methods applied to input data and processed data (output information) that is subject to data mining.
This section includes the methods suggested for collecting, cleaning, integration, selection and transformation phases of input data that will be subject to data mining.
Although it varies according to the application used or the state of trust to the institution collecting the data, it is recommended that the original values not be stored and used only in the conversion process in order to prevent disclosure of privacy. For example, the data collected with sensors, which are now widely used with internet of things, can be transformed at the stage it collects, randomizing the obtained values and transforming the raw data before being used in data mining.
In this section, data perturbation, randomization, suppression, data swapping, anonymity, cryptography and differential privacy methods are discussed.
The creation of data resistant to privacy attacks can be done by perturbation significantly preserving the statistical integrity of the data [15, 16]. Randomization of the original data is widely used in data perturbation [17, 18, 19]. Another approach is the Microaggregation method [20].
In the randomization method, noise signals are added to the data with a known statistical distribution, so when data mining methods are applied, the original data distribution can be reconstructed without accessing the original data. For this, data providers first randomize their data and then transmit them to the data recipient. Then, receiving this random data, the data receiver calculates the distribution using distribution reconstruction methods.
During the data collection phase, it can be calculated independently for each data, and after the original distribution is reconstructed, the statistical properties of the data are preserved. For example; the result of the randomization of A with B is C (C = A + B) if A be the original data distribution, and B, a publicly known noise distribution independent of A. Then, A may be reconstructed with “A= C− B”. However, this reconstruction process may not be successful if B has a large variance and C’s sample size is not large enough. As a solution, approaches that implement the Bayes [21], or EM [22] formula can be used. While the randomization method limits data usage to the distribution of C, it requires a lot of noise to hide outliers. Because in this approach, outliers are more vulnerable to attacks when compared to values in denser regions in the data. Although this reduces the use of the data for mining purposes, it may be necessary to add too much noise to all records in the data that would result in loss of information, in order to prevent it [7].
Randomly generated values can be added to the original data with an additive or multiplicative method [23]. The aim is to ensure that noise added to individual records for privacy is non-extractable. Multiplicative Noise is more efficient than the Additive Noise method because it is more difficult to predict the original values.
With Microaggregation method, all records in the data set are first arranged in a meaningful order and then the whole set is divided into a certain number of subsets. Then, by taking the average of the value of each subset of the specified attribute, the value of that attribute of the subset is replaced with the average value. Thus, the average value of that attribute for the entire data set will not change.
Since data perturbation approaches have a negative impact on data utility and are not resistant to attacks, they are often not preferred in utility-based data models.
Data Suppression technique is a technique that tries to prevent the disclosure of confidential information by replacing some values with a special value. In some cases, it is the process of deleting cell values or the entire record [24]. In this way, confidential data can be changed, rounded, generalized or mixed and made available in data mining applications [25].
An example of Suppression may be changing the age attribute in records from 28 to 35, city attribute from Glasgow to Edinburgh, or generalizing the age attribute from 28 to 25–30, and Glasgow data as Scotland. Using these methods in big data can reduce data quality and change general statistics, this may result in data becoming unusable [26]. Another problem is that information is deliberately distorted to suppression. Data providers can obtain artificial inferences that are inaccurate and serve a purpose with the reported values [27].
On the other hand, suppression should not be used when data mining requires full access to sensitive values. For sensitive information in a record, the method of limiting the identity link of a record may be preferred instead.
A technique tries to prevent the disclosure of private information by swapping values between different records.
Data swapping can be explained as each data provider scrambling data by exchanging their data with other data providers, especially in cases where there are more than one data provider. The advantage of the technique is that the data does not affect the sub-order sums, thus allowing accurate and complete collective calculations.
With this technique, as the result of data exchanges, private data can be easily exposed in the system, for this reason it is recommended to use only in safe environments. It can be used in conjunction with other methods such as k-anonymity without violating privacy definitions.
Cryptography is a technique that converts plain text to cipher text using various encryption algorithms to encode messages in a way that cannot be read. It is a method of storing and transmitting data in specific form using cryptography techniques so that only intended persons can read and process it.
In data mining applications, cryptography-based techniques are used to protect privacy during data collection and data storage [25, 28], and guarantee a very high level of data privacy [23]. Encryption is generally costly due to time and computational complexity. Hence, as the volume of data increases, the time to process on encrypted data increases and creates a potential barrier to real-time analysis [29].
Secure multiparty computing (SMC) is a special encryption protocol where, when there is more than one participating party, the interested parties learn nothing but results [30, 31]. The SMC calculation must be done carefully so that it does not reveal sensitive data, but the calculated result can enable the parties to estimate the value of sensitive data.
Many privacy conversions are for creating groups between anonymous records that are converted in a group-specific manner. A number of techniques have been proposed for group anonymity in different studies, such as k-anonymity, l-diversity, and t-proximity methods. The comparison of group anonymity methods is given in Table 1.
Method | Based on | Vulnerability under | Strong against |
---|---|---|---|
k-anonymity | Sensitive data disclosure | Homogeneity attack | record linkage only |
l-diversity | Semantic similarity of sensitive data | Skewness attack | record linkage and attribute linkage |
t-closeness | Distance measures | Attribute linkage attack | probabilistic attack and attribute linkage |
Group based anonymity methods.
The k-anonymity method proposed by Samarati and Sweeney in the anonymization of data is a method of providing privacy that protects the identity of the data subject most commonly used in the publication of data [32].
The method ensures that after removing the ID attributes from the table, the QID values of at least k records in the table to be published are the same.
Since the QID attributes of each record in the table published by this method are the same as the other k-1 records, it is aimed to prevent identity disclosure.
To reduce the level of detail of the data representation, some attributes can be replaced with more general values (data swapping), some data points can be eliminated, or descriptive data can be deleted (suppression). However, while k-Anonymity provides protection against attacks on the disclosure of identities, it does not protect against attacks on disclosure of attributes. It is also more convenient to use for individual data rather than directly applying it to restrict data mining results that protect privacy. Besides, k-anonymity fully protects the privacy of users when it comes to the homogeneity of sensitive values in the data. Providing optimum k-anonymity is a problem in the NP-Hard class and approximate solutions have been proposed to avoid calculation difficulties [33].
In the literature, different studies such as k-neighbor anonymity, k-degree anonymity, cotomorphism anonymity, k-candidate anonymity and l-grouping derived from the k-anonymity approach have been proposed according to the structural features of the data.
The l-diversity approach was proposed by Ashwin Machanavijjhala in 2007 to address the weaknesses (homogeneity attack) of the k-anonymity model [34].
This method aims to prevent the disclosure of confidential information indirectly by ensuring that each QID group has at least l well-represented sensitive value.
L-diversity only guarantees the diversity of sensitive features within each QID group, but the problem that different values may belong to the same category is not solved.
In other words, it is not resistant to attacks based on semantic similarity between values.
In order to balance the semantic similarities of SA attributes within each QID group, it has been proposed to solve the limitations of the l-diversity approach by guaranteeing t-closeness to each other [35].
Accordingly, in t-closeness method, the distance of the distribution of sensitive attributes in any equivalence class to the distribution of the attributes in the whole table will not exceed a threshold value (t). While the t-closeness approach provides protection against disclosure of attributes, it cannot protect against disclosure of identities. In addition, it limits the usefulness of the information disclosed however, by setting the t-threshold in applications, it can exchange benefit and privacy.
In the protection of privacy, t-proximity and k-anonymity methods are used together to protect against attacks on identity disclosure and quality [36].
The outputs of data mining algorithms can disclose information without open access to the original data set. Sensitive information can be accessed through studies on the results. For this reason, data mining output must also protect privacy.
This method is examined as query inference control and query auditing. In the query inference control, the input data or the output of the query is controlled. In t Query auditing, the queries made on the outputs obtained by data mining are audited. If the audited query enables the disclosure of confidential data, the query request is denied. Although it limits data mining, it plays an active role in ensuring privacy. Query auditing can be done online or offline. Since queries and query results are already known in offline control, it is evaluated whether the results violate privacy. In online auditing, since the queries are not known, privacy metrics are carried out simultaneously during the execution of the query. This method is examined within the scope of statistical database security.
k-anonymity, l-diversity and t-closeness approaches are holistic approaches that try to protect the whole data privacy. In some cases, there is a need to protect the privacy of data at the record level. For this reason, differential privacy approach has been proposed by Dwork to protect the privacy of database query results [37].
With this model, the attacks that may occur between sending database queries and responding to the query are targeted. Failure to distinguish from which database the answer of the same query, made in more than one database, is returned will prevent the disclosure of the existence of a single record between databases.
In addition, when querying output data, it can be ensured that the query results obtain approximate values with the database approach technique. Also, it is recommended to keep the data in the system mixed during the execution of queries, just like the data collection phases to protect data privacy.
In data mining, it is one of the most frequently used methods of Association Rules to reveal the nature of interesting associations between binary variables. During data mining, some rules may explicitly disclose private information about the data subject (individual or group).
Unnecessary and information-leaking rules may occur in some relationships. The aim of the Association rule hiding technique first proposed by Atallah [38] is to protect privacy by hiding all sensitive rules. The weakness with this technique is that a significant number of insensitive rules can be hidden incorrectly [39].
In this section, the common types of attacks that lead to the development of the methods given above and lead to privacy violations are summarized [6].
Attacks that are made by making use of the intuitive similarity of sensitive attribute values within anonymous groups.
In this case, it is not sufficient for the sensitive attribute values to be different from each other in terms of protecting privacy [40]. This attack can be prevented by calculating the similarities of sensitive attributes in the same anonymous group and by providing solutions to include similar sensitive attribute values in different groups.
Background knowledge is non-sensitive information that can be obtained from data published by different organizations, social networks and media even by using social engineering methods. Background knowledge obtained by attacker’s causes privacy attacks and breaches.
Data subject’s privacy violation occurs as a result of associating background knowledge with other records using data binding methods [41].
In addition, when information obtained from data owners through requests such as promotion, campaign, research, etc. is associated with background information, it is not even possible that it will not cause a violation of privacy.
In cases where all or most of the sensitive attributes in the groups included in the anonymous tables are similar, the privacy of data owners is at risk of violation.
In order to prevent homogeneity attacks, it is necessary to prevent similar sensitive attributes within the groups in the anonymous table from being in the same group or to reproduce heterogeneous records by diluting the homogeneous attributes with the record duplication approach [34].
The statistical distribution of sensitive attribute values in published or shared anonymous data sets can lead to the success of skewness attacks against privacy. The distortion in the general distribution of sensitive attributes occurs when these values are too dominant and anonymous data sets become vulnerable [35].
It has been shown that with theoretical and experimental methods, interchangeability concepts and inferences about privacy can be made with Definetti’s theorem [42]. The fact that the people who want to carry out this attack do not need extensive background knowledge makes this attack attractive. An attacker can perform an attack using machine-learning techniques on non-sensitive attributes in the dataset.
The fact that the information about which data anonymization algorithm is used in the data mining application is public is also considered as a privacy vulnerability [43]. It is based on the principle that changes on data should remain at minimum level in anonymization processes and should not be overly anonymized.
Publicly declaring previously published generalized data over time causes this attack. For this reason, previously published tables should be used and new records that may cause data disclosure should not be shared [44].
The fact that the digitalization process has become mandatory all over the world with Covid-19 pandemic has accelerated the data flow. It has become even more important to collect the necessary data, analyze it correctly and reveal reliable information. This situation has triggered the use of data mining methods to increase productivity and provide high quality products/services in almost all sectors. While applying data mining methods, it is obvious that if privacy is not taken into consideration during the data life cycle, irreversible damages will occur for individuals/institutions and organizations.
In order to increase the access and benefits of data mining technology, before applying PPDM techniques, “privacy” should be defined precisely, measurement metrics should be determined and the results obtained should be evaluated with these metrics. For this reason, this study primarily focused on the definition of privacy. The term privacy is quite extensive and does not have a standard definition. It is quite challenging in measuring privacy, as there is no standard privacy definition. Some measurement metrics are mentioned in this chapter, but metrics are usually determined by application. The lack of a standard privacy measurement metric also make challenging the comparison and evaluation of the developed PPDM techniques.
In the age of digital and online business, privacy protection needs to be done at the individual and organizational levels. Privacy protection at the individual level depends on person who is influenced by religious beliefs, community norms and culture. For this reason, the concept of personalized privacy, which allows individuals to have a certain level of control over their data, has been proposed. However, it has been observed that there are difficulties in implementing personalized privacy, as people think that compromising their privacy for applications they think is well-intentioned will not damage. Therefore, in the context of personalized privacy, new solutions are required for the trade-off between privacy and utility.
To effectively protect organizational level data privacy [7]; Policy makers in organizations should support privacy-enhancing technical architectures/models to securely collect, analyze and share data. Laws, regulations and fundamental principles regarding privacy should be analyzed by organizations. It is necessary for organizations to include the data owners in their assessment of privacy and security practices. Data owners should involve the whole process about what data is collected, how it is analyzed and for what purpose it is used. In addition, they should have the right to correct personal data in order to avoid negative consequences of incorrect data. Organizations should employ data privacy analysts, data security scientists, and data privacy architects who can develop data mining applications securely.
From a technical point of view, methods that protect confidentiality in data analytics are still in their infancy. Although studies continue by different scientific communities such as cryptography, database management and data mining, an interdisciplinary study should be conducted on PPDM. For example, the difficulties encountered in this process should also be addressed from a legal perspective. Thus, a better roadmap for next-generation privacy-preserving data mining design can be developed by academic researchers and industrial practitioners.
Businesses and even governments collect data through many digital platforms (social media, e-health, e-commerce, entertainment, e-government etc.) they use to serve their customers/citizens. The data collected can be sensitive data and this data can be stored, analyzed and, in good probability, anonymized and shared with others. In studies where data is used at any stage of the life cycle, regardless of the purpose, it is necessary to explain a privacy permission and the reason why the data should be accessed. Privacy Preserving Data Mining (PPDM) techniques are being developed to allow information to be extracted from data without disclosing sensitive information.
There is no single optimal PPDM technique for any stage of the data lifecycle. The PPDM technique to be applied varies according to the application requirements, such as the desired privacy level, data size and volume, tolerable information loss level, transaction complexity, etc. Because different application areas have different rules, assumptions and requirements regarding privacy.
In this chapter, the previously proposed PPDM techniques are examined in two sections. First section includes the methods suggested for collecting, cleaning, integration, selection and transformation phases of input data that will be subject to data mining and second section covers methods applied to processed data. Finally, attacks against the privacy of data mining applications are given in this chapter.
Edited by Jan Oxholm Gordeladze, ISBN 978-953-51-3020-8, Print ISBN 978-953-51-3019-2, 336 pages,
\nPublisher: IntechOpen
\nChapters published March 22, 2017 under CC BY 3.0 license
\nDOI: 10.5772/61430
\nEdited Volume
This book serves as a comprehensive survey of the impact of vitamin K2 on cellular functions and organ systems, indicating that vitamin K2 plays an important role in the differentiation/preservation of various cell phenotypes and as a stimulator and/or mediator of interorgan cross talk. Vitamin K2 binds to the transcription factor SXR/PXR, thus acting like a hormone (very much in the same manner as vitamin A and vitamin D). Therefore, vitamin K2 affects a multitude of organ systems, and it is reckoned to be one positive factor in bringing about "longevity" to the human body, e.g., supporting the functions/health of different organ systems, as well as correcting the functioning or even "curing" ailments striking several organs in our body.
\\n\\nChapter 1 Introductory Chapter: Vitamin K2 by Jan Oxholm Gordeladze
\\n\\nChapter 2 Vitamin K, SXR, and GGCX by Kotaro Azuma and Satoshi Inoue
\\n\\nChapter 3 Vitamin K2 Rich Food Products by Muhammad Yasin, Masood Sadiq Butt and Aurang Zeb
\\n\\nChapter 4 Menaquinones, Bacteria, and Foods: Vitamin K2 in the Diet by Barbara Walther and Magali Chollet
\\n\\nChapter 5 The Impact of Vitamin K2 on Energy Metabolism by Mona Møller, Serena Tonstad, Tone Bathen and Jan Oxholm Gordeladze
\\n\\nChapter 6 Vitamin K2 and Bone Health by Niels Erik Frandsen and Jan Oxholm Gordeladze
\\n\\nChapter 7 Vitamin K2 and its Impact on Tooth Epigenetics by Jan Oxholm Gordeladze, Maria A. Landin, Gaute Floer Johnsen, Håvard Jostein Haugen and Harald Osmundsen
\\n\\nChapter 8 Anti-Inflammatory Actions of Vitamin K by Stephen J. Hodges, Andrew A. Pitsillides, Lars M. Ytrebø and Robin Soper
\\n\\nChapter 9 Vitamin K2: Implications for Cardiovascular Health in the Context of Plant-Based Diets, with Applications for Prostate Health by Michael S. Donaldson
\\n\\nChapter 11 Vitamin K2 Facilitating Inter-Organ Cross-Talk by Jan O. Gordeladze, Håvard J. Haugen, Gaute Floer Johnsen and Mona Møller
\\n\\nChapter 13 Medicinal Chemistry of Vitamin K Derivatives and Metabolites by Shinya Fujii and Hiroyuki Kagechika
\\n"}]'},components:[{type:"htmlEditorComponent",content:'This book serves as a comprehensive survey of the impact of vitamin K2 on cellular functions and organ systems, indicating that vitamin K2 plays an important role in the differentiation/preservation of various cell phenotypes and as a stimulator and/or mediator of interorgan cross talk. Vitamin K2 binds to the transcription factor SXR/PXR, thus acting like a hormone (very much in the same manner as vitamin A and vitamin D). Therefore, vitamin K2 affects a multitude of organ systems, and it is reckoned to be one positive factor in bringing about "longevity" to the human body, e.g., supporting the functions/health of different organ systems, as well as correcting the functioning or even "curing" ailments striking several organs in our body.
\n\nChapter 1 Introductory Chapter: Vitamin K2 by Jan Oxholm Gordeladze
\n\nChapter 2 Vitamin K, SXR, and GGCX by Kotaro Azuma and Satoshi Inoue
\n\nChapter 3 Vitamin K2 Rich Food Products by Muhammad Yasin, Masood Sadiq Butt and Aurang Zeb
\n\nChapter 4 Menaquinones, Bacteria, and Foods: Vitamin K2 in the Diet by Barbara Walther and Magali Chollet
\n\nChapter 5 The Impact of Vitamin K2 on Energy Metabolism by Mona Møller, Serena Tonstad, Tone Bathen and Jan Oxholm Gordeladze
\n\nChapter 6 Vitamin K2 and Bone Health by Niels Erik Frandsen and Jan Oxholm Gordeladze
\n\nChapter 7 Vitamin K2 and its Impact on Tooth Epigenetics by Jan Oxholm Gordeladze, Maria A. Landin, Gaute Floer Johnsen, Håvard Jostein Haugen and Harald Osmundsen
\n\nChapter 8 Anti-Inflammatory Actions of Vitamin K by Stephen J. Hodges, Andrew A. Pitsillides, Lars M. Ytrebø and Robin Soper
\n\nChapter 9 Vitamin K2: Implications for Cardiovascular Health in the Context of Plant-Based Diets, with Applications for Prostate Health by Michael S. Donaldson
\n\nChapter 11 Vitamin K2 Facilitating Inter-Organ Cross-Talk by Jan O. Gordeladze, Håvard J. Haugen, Gaute Floer Johnsen and Mona Møller
\n\nChapter 13 Medicinal Chemistry of Vitamin K Derivatives and Metabolites by Shinya Fujii and Hiroyuki Kagechika
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Few sections of this chapter has also elaborated the utility of the artificial intelligence-inspired fuzzy logic-based decision system which has already been a part of previous researches.",book:{id:"8347",slug:"computer-architecture-in-industrial-biomechanical-and-biomedical-engineering",title:"Computer Architecture in Industrial, Biomechanical and Biomedical Engineering",fullTitle:"Computer Architecture in Industrial, Biomechanical and Biomedical Engineering"},signatures:"Ravi Pratap Singh, Ravinder Kataria and Sandeep Singhal",authors:[{id:"265010",title:"Dr.",name:"Ravi Pratap",middleName:null,surname:"Singh",slug:"ravi-pratap-singh",fullName:"Ravi Pratap Singh"},{id:"265017",title:"Dr.",name:"Ravinder",middleName:null,surname:"Kataria",slug:"ravinder-kataria",fullName:"Ravinder Kataria"},{id:"271624",title:"Dr.",name:"Sandeep",middleName:null,surname:"Singhal",slug:"sandeep-singhal",fullName:"Sandeep Singhal"}]},{id:"52202",doi:"10.5772/64980",title:"Computer-Aided Diagnosis in Neuroimaging",slug:"computer-aided-diagnosis-in-neuroimaging",totalDownloads:1810,totalCrossrefCites:3,totalDimensionsCites:5,abstract:"This chapter is intended to provide an overview to the most used methods for computer-aided diagnosis in neuroimaging and its application to neurodegenerative diseases. The fundamental preprocessing steps, and how they are applied to different image modalities, will be thoroughly presented. We introduce a number of widely used neuroimaging analysis algorithms, together with a wide overview on the recent advances in brain imaging processing. Finally, we provide a general conclusion on the state of the art in brain imaging processing and possible future developments.",book:{id:"5379",slug:"computer-aided-technologies-applications-in-engineering-and-medicine",title:"Computer-aided Technologies",fullTitle:"Computer-aided Technologies - Applications in Engineering and Medicine"},signatures:"Francisco J. Martínez-Murcia, Juan Manuel Górriz and Javier\nRamírez",authors:[{id:"17445",title:"Dr.",name:"Javier",middleName:null,surname:"Ramírez",slug:"javier-ramirez",fullName:"Javier Ramírez"},{id:"187376",title:"M.Sc.",name:"Francisco J.",middleName:null,surname:"Martínez-Murcia",slug:"francisco-j.-martinez-murcia",fullName:"Francisco J. Martínez-Murcia"},{id:"187381",title:"Prof.",name:"Juan Manuel",middleName:null,surname:"Górriz",slug:"juan-manuel-gorriz",fullName:"Juan Manuel Górriz"}]},{id:"52953",doi:"10.5772/65620",title:"Computer-Aided Clinical Decision Support Systems for Atrial Fibrillation",slug:"computer-aided-clinical-decision-support-systems-for-atrial-fibrillation",totalDownloads:1902,totalCrossrefCites:1,totalDimensionsCites:5,abstract:"Clinical decision support systems (clinical DSSs) are widely used today for various clinical applications such as diagnosis, treatment, and recovery. Clinical DSS aims to enhance the end‐to‐end therapy management for the doctors, and also helps to provide improved experience for patients during each phase of the therapy. The goal of this chapter is to provide an insight into the clinical DSS associated with the highly prevalent heart rhythm disorder, atrial fibrillation (AF). The use of clinical DSS in AF management is ubiquitous, starting from detection of AF through sophisticated electrophysiology treatment procedures, all the way to monitoring the patient's health during follow‐ups. Most of the software associated with AF DSS are developed based on signal processing, image processing, and artificial intelligence techniques. The chapter begins with a brief description of DSS in general and then introduces DSS that are used for various clinical applications. The chapter continues with a background on AF and some relevant mechanisms. Finally, a couple of clinical DSS used today in regard with AF are discussed, along with some proposed methods for potential implementation of clinical DSS for detection of AF, prediction of an AF treatment outcome, and localization of AF targets during a treatment procedure.",book:{id:"5379",slug:"computer-aided-technologies-applications-in-engineering-and-medicine",title:"Computer-aided Technologies",fullTitle:"Computer-aided Technologies - Applications in Engineering and Medicine"},signatures:"Prasanth Ganesan, Mark Sterling, Steven Ladavich and Behnaz\nGhoraani",authors:[{id:"188108",title:"Dr.",name:"Behnaz",middleName:null,surname:"Ghoraani",slug:"behnaz-ghoraani",fullName:"Behnaz Ghoraani"},{id:"188519",title:"M.Sc.",name:"Prasanth",middleName:null,surname:"Ganesan",slug:"prasanth-ganesan",fullName:"Prasanth Ganesan"},{id:"188520",title:"Dr.",name:"Mark",middleName:null,surname:"Sterling",slug:"mark-sterling",fullName:"Mark Sterling"},{id:"188521",title:"MSc.",name:"Steven",middleName:null,surname:"Ladavich",slug:"steven-ladavich",fullName:"Steven Ladavich"}]},{id:"53083",doi:"10.5772/66202",title:"Introductory Chapter: Integration of Computer-Aided Technologies in Product Lifecycle Management (PLM) and Human Lifecycle Management (HUM)",slug:"introductory-chapter-integration-of-computer-aided-technologies-in-product-lifecycle-management-plm-",totalDownloads:2131,totalCrossrefCites:5,totalDimensionsCites:4,abstract:null,book:{id:"5379",slug:"computer-aided-technologies-applications-in-engineering-and-medicine",title:"Computer-aided Technologies",fullTitle:"Computer-aided Technologies - Applications in Engineering and Medicine"},signatures:"Razvan Udroiu",authors:[{id:"13146",title:"Prof.",name:"Razvan",middleName:null,surname:"Udroiu",slug:"razvan-udroiu",fullName:"Razvan Udroiu"}]}],mostDownloadedChaptersLast30Days:[{id:"67425",title:"Impact of Medical Advancement: Prostheses",slug:"impact-of-medical-advancement-prostheses",totalDownloads:1168,totalCrossrefCites:3,totalDimensionsCites:3,abstract:"This chapter shall provide a brief introduction to the prostheses and their development in the current advance technological era. The prosthesis design, control, and architecture completely changed with the change in the amputation level. The transradial amputee stump design, electronics, battery, and circuit placement change significantly with the change of the residual arm of the amputee. This leads to designing the prostheses with the focus of the amputation level and ease of customization. Recent development in the 3D printing and open source prosthetic design leads the user to choose, modify, and print the prostheses with the required sets of functionalities. In this chapter, a brief introduction of the prostheses has been given, starting with the types of prostheses according to the level of amputation and functionality. Then, the state-of-the-art prostheses available commercially and under research will be introduced. Afterward, the 3D printed prostheses are discussed. This chapter will end with the comparison of the medical advancement over the average life of people in general and comparison of the same for countries with low and high per capita income.",book:{id:"8347",slug:"computer-architecture-in-industrial-biomechanical-and-biomedical-engineering",title:"Computer Architecture in Industrial, Biomechanical and Biomedical Engineering",fullTitle:"Computer Architecture in Industrial, Biomechanical and Biomedical Engineering"},signatures:"Samreen Hussain, Sarmad Shams and Saad Jawaid Khan",authors:[{id:"281496",title:"Prof.",name:"Samreen",middleName:null,surname:"Hussain",slug:"samreen-hussain",fullName:"Samreen Hussain"},{id:"281500",title:"Dr.",name:"Sarmad",middleName:null,surname:"Shams",slug:"sarmad-shams",fullName:"Sarmad Shams"},{id:"298862",title:"Dr.",name:"Saad",middleName:null,surname:"Jawaid Khan",slug:"saad-jawaid-khan",fullName:"Saad Jawaid Khan"}]},{id:"52413",title:"Computer-Aided Techniques for Geometry Assurance",slug:"computer-aided-techniques-for-geometry-assurance",totalDownloads:2363,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Geometry assurance can be described as a number of activities, all contributing to minimize the effect of geometrical variation in a final product. This work aims to introduce a new type of comparison between a computer-aided technique for geometry assurance and some models proposed by the literature. In particular, the aim of this work is to solve, through a computer-aided technique, some case studies that were already solved by different methods of the literature. The different case studies that have been introduced and solved in this paper aim to highlight the potentialities and the limits in using a computer-aided technique for geometry assurance. Because this type of comparison is not present in the literature yet, this work wants to place the emphasis on the fact that till now there is not a unique approach to solve problems of geometry assurance and no approach can be defined as better than another, in terms of results.",book:{id:"5379",slug:"computer-aided-technologies-applications-in-engineering-and-medicine",title:"Computer-aided Technologies",fullTitle:"Computer-aided Technologies - Applications in Engineering and Medicine"},signatures:"Andrea Corrado and Wilma Polini",authors:[{id:"16151",title:"Dr.",name:"Wilma",middleName:null,surname:"Polini",slug:"wilma-polini",fullName:"Wilma Polini"},{id:"190416",title:"Ph.D. Student",name:"Andrea",middleName:null,surname:"Corrado",slug:"andrea-corrado",fullName:"Andrea Corrado"}]},{id:"67441",title:"Human-Computer/Device Interaction",slug:"human-computer-device-interaction",totalDownloads:764,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Any interaction refers to the communication between two or more entities (be it abstract/conceptual or physical entity). Successful interaction is equated from the properties of each entity involved in the interaction as well as the capabilities of the interacting entities. With the diversified use and application of computers and specialized devices for specific tasks, such as biomechanical and biomedical devices, interaction design needs to further study the context of the tasks as well. Moreover, with the inclusion of embedded systems and smart devices, instead of focusing only on the hardware performance, the computer architecture needs to consider the opportunities. Especially, HCI can be improved as the current technologies are giving an opportunity for building smart interaction where the user interacts with devices implicitly and in less obtrusive way. In light of this, the design and architecture of an engineered product need to strive for making the product usable and used while making it useful to the user. And this can be achieved if interaction design is dictated by scrutinizing the user model with respects to the usability attributes in view of the context of its task as well as the platform capabilities and constraints as discussed in this chapter.",book:{id:"8347",slug:"computer-architecture-in-industrial-biomechanical-and-biomedical-engineering",title:"Computer Architecture in Industrial, Biomechanical and Biomedical Engineering",fullTitle:"Computer Architecture in Industrial, Biomechanical and Biomedical Engineering"},signatures:"Dagmawi Lemma Gobena",authors:[{id:"284850",title:"Dr.",name:"Dagmawi Lemma",middleName:null,surname:"Gobena",slug:"dagmawi-lemma-gobena",fullName:"Dagmawi Lemma Gobena"}]},{id:"67484",title:"Human Behavior Modeling: The Necessity of Narrative",slug:"human-behavior-modeling-the-necessity-of-narrative",totalDownloads:932,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"As progress is made in the development of artificial intelligent mechanisms to assist human research into aspects of industrial, biomechanical and biomedical engineering, the conceptualization of mental behavior of human entities become more vital and more central to the success of any interaction between machine and humans. This discussion explores one of the most important features of human behavior, the fundamental and irreversible concept of narrative. The narrative is the essential construct for the theoretical understanding and presentation of human communication, including formal and informal logic, emotional wonder and desperation, noble and selfish biases, nationalism and globalist politics, and any form of spiritualism. This presentation offers a working definition of human narrative and proposes its basic structure that must be represented by any computer system which is required to deal with human behavior.",book:{id:"8347",slug:"computer-architecture-in-industrial-biomechanical-and-biomedical-engineering",title:"Computer Architecture in Industrial, Biomechanical and Biomedical Engineering",fullTitle:"Computer Architecture in Industrial, Biomechanical and Biomedical Engineering"},signatures:"Roger Parker",authors:[{id:"284043",title:"Ph.D.",name:"Roger",middleName:null,surname:"Parker",slug:"roger-parker",fullName:"Roger Parker"}]},{id:"66967",title:"Decision-Making in Real-Life Industrial Environment through Graph Theory Approach",slug:"decision-making-in-real-life-industrial-environment-through-graph-theory-approach",totalDownloads:841,totalCrossrefCites:9,totalDimensionsCites:9,abstract:"The approach called as “graph theory and matrix approach” has been well employed in numerous research studies with a view to perform the decision-making while the situation is becoming perplexed type or where there is a very strong relative importance of one parameter over another. In such cases, the said graph theory and matrix method provides very suitable and fruitful solutions to make the decision to its final effective extent. The further improvements and the outcome enhancement can also be revealed through the use of combined practice of graph theory results along with some artificial intelligence-inspired logics and practices such as fuzzy logic, artificial neural network, etc. The significance and applicability of said method in vast fields of science, engineering, and research are also proved. Nowadays, our manufacturing sectors are getting up to date through the applications of artificial intelligence and several software-based directions. This is all to enhance the overall machine system performance with a view to improve desired performance characteristics of the process under the study. Few sections of this chapter has also elaborated the utility of the artificial intelligence-inspired fuzzy logic-based decision system which has already been a part of previous researches.",book:{id:"8347",slug:"computer-architecture-in-industrial-biomechanical-and-biomedical-engineering",title:"Computer Architecture in Industrial, Biomechanical and Biomedical Engineering",fullTitle:"Computer Architecture in Industrial, Biomechanical and Biomedical Engineering"},signatures:"Ravi Pratap Singh, Ravinder Kataria and Sandeep Singhal",authors:[{id:"265010",title:"Dr.",name:"Ravi Pratap",middleName:null,surname:"Singh",slug:"ravi-pratap-singh",fullName:"Ravi Pratap Singh"},{id:"265017",title:"Dr.",name:"Ravinder",middleName:null,surname:"Kataria",slug:"ravinder-kataria",fullName:"Ravinder Kataria"},{id:"271624",title:"Dr.",name:"Sandeep",middleName:null,surname:"Singhal",slug:"sandeep-singhal",fullName:"Sandeep Singhal"}]}],onlineFirstChaptersFilter:{topicId:"716",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:317,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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",coverUrl:"https://cdn.intechopen.com/series/covers/3.jpg",latestPublicationDate:"May 13th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:8,editor:{id:"419588",title:"Ph.D.",name:"Sergio",middleName:"Alexandre",surname:"Gehrke",slug:"sergio-gehrke",fullName:"Sergio Gehrke",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038WgMKQA0/Profile_Picture_2022-06-02T11:44:20.jpg",biography:"Dr. Sergio Alexandre Gehrke is a doctorate holder in two fields. The first is a Ph.D. in Cellular and Molecular Biology from the Pontificia Catholic University, Porto Alegre, Brazil, in 2010 and the other is an International Ph.D. in Bioengineering from the Universidad Miguel Hernandez, Elche/Alicante, Spain, obtained in 2020. In 2018, he completed a postdoctoral fellowship in Materials Engineering in the NUCLEMAT of the Pontificia Catholic University, Porto Alegre, Brazil. He is currently the Director of the Postgraduate Program in Implantology of the Bioface/UCAM/PgO (Montevideo, Uruguay), Director of the Cathedra of Biotechnology of the Catholic University of Murcia (Murcia, Spain), an Extraordinary Full Professor of the Catholic University of Murcia (Murcia, Spain) as well as the Director of the private center of research Biotecnos – Technology and Science (Montevideo, Uruguay). Applied biomaterials, cellular and molecular biology, and dental implants are among his research interests. He has published several original papers in renowned journals. In addition, he is also a Collaborating Professor in several Postgraduate programs at different universities all over the world.",institutionString:null,institution:{name:"Universidad Católica San Antonio de Murcia",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:2,paginationItems:[{id:"1",title:"Oral Health",coverUrl:"https://cdn.intechopen.com/series_topics/covers/1.jpg",isOpenForSubmission:!0,editor:{id:"173955",title:"Prof.",name:"Sandra",middleName:null,surname:"Marinho",slug:"sandra-marinho",fullName:"Sandra Marinho",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRGYMQA4/Profile_Picture_2022-06-01T13:22:41.png",biography:"Dr. Sandra A. Marinho is an Associate Professor and Brazilian researcher at the State University of Paraíba (Universidade Estadual da Paraíba- UEPB), Campus VIII, located in Araruna, state of Paraíba since 2011. She holds a degree in Dentistry from the Federal University of Alfenas (UNIFAL), while her specialization and professional improvement in Stomatology took place at Hospital Heliopolis (São Paulo, SP). Her qualifications are: a specialist in Dental Imaging and Radiology, Master in Dentistry (Periodontics) from the University of São Paulo (FORP-USP, Ribeirão Preto, SP), and Doctor (Ph.D.) in Dentistry (Stomatology Clinic) from Hospital São Lucas of the Pontifical Catholic University of Rio Grande do Sul (HSL-PUCRS, Porto Alegre, RS). She held a postdoctoral internship at the Federal University from Jequitinhonha and Mucuri Valleys (UFVJM, Diamantina, MG). She is currently a member of the Brazilian Society for Dental Research (SBPqO) and the Brazilian Society of Stomatology and Pathology (SOBEP). Dr. Marinho's experience in Dentistry mainly covers the following subjects: oral diagnosis, oral radiology; oral medicine; lesions and oral infections; oral pathology, laser therapy and epidemiological studies.",institutionString:null,institution:{name:"State University of Paraíba",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null},{id:"2",title:"Prosthodontics and Implant Dentistry",coverUrl:"https://cdn.intechopen.com/series_topics/covers/2.jpg",isOpenForSubmission:!0,editor:{id:"179568",title:"Associate Prof.",name:"Wen Lin",middleName:null,surname:"Chai",slug:"wen-lin-chai",fullName:"Wen Lin Chai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRHGAQA4/Profile_Picture_2022-05-23T14:31:12.png",biography:"Professor Dr. Chai Wen Lin is currently a lecturer at the Department of Restorative Dentistry, Faculty of Dentistry of the University of Malaya. She obtained a Master of Dental Science in 2006 and a Ph.D. in 2011. Her Ph.D. research work on the soft tissue-implant interface at the University of Sheffield has yielded several important publications in the key implant journals. She was awarded an Excellent Exchange Award by the University of Sheffield which gave her the opportunity to work at the famous Faculty of Dentistry of the University of Gothenburg, Sweden, under the tutelage of Prof. Peter Thomsen. In 2016, she was appointed as a visiting scholar at UCLA, USA, with attachment in Hospital Dentistry, and involvement in research work related to zirconia implant. In 2016, her contribution to dentistry was recognized by the Royal College of Surgeon of Edinburgh with her being awarded a Fellowship in Dental Surgery. She has authored numerous papers published both in local and international journals. She was the Editor of the Malaysian Dental Journal for several years. Her main research interests are implant-soft tissue interface, zirconia implant, photofunctionalization, 3D-oral mucosal model and pulpal regeneration.",institutionString:null,institution:{name:"University of Malaya",institutionURL:null,country:{name:"Malaysia"}}},editorTwo:{id:"479686",title:"Dr.",name:"Ghee Seong",middleName:null,surname:"Lim",slug:"ghee-seong-lim",fullName:"Ghee Seong Lim",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003ScjLZQAZ/Profile_Picture_2022-06-08T14:17:06.png",biography:"Assoc. Prof Dr. Lim Ghee Seong graduated with a Bachelor of Dental Surgery from University of Malaya, Kuala Lumpur in 2008. He then pursued his Master in Clinical Dentistry, specializing in Restorative Dentistry at Newcastle University, Newcastle, UK, where he graduated with distinction. He has also been awarded the International Training Fellowship (Restorative Dentistry) from the Royal College of Surgeons. His passion for teaching then led him to join the faculty of dentistry at University Malaya and he has since became a valuable lecturer and clinical specialist in the Department of Restorative Dentistry. He is currently the removable prosthodontic undergraduate year 3 coordinator, head of the undergraduate module on occlusion and a member of the multidisciplinary team for the TMD clinic. He has previous membership in the British Society for Restorative Dentistry, the Malaysian Association of Aesthetic Dentistry and he is currently a lifetime member of the Malaysian Association for Prosthodontics. Currently, he is also the examiner for the Restorative Specialty Membership Examinations, Royal College of Surgeons, England. He has authored and co-authored handful of both local and international journal articles. 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Dr. Khalid\\'s research interests include leadership and negotiations, digital transformations, gamification, eLearning, blockchain, Big Data, and management of information technology. Dr. Bilal Khalid also serves as an academic editor at Education Research International and a reviewer for international journals.",institutionString:"KMITL Business School",institution:{name:"King Mongkut's Institute of Technology Ladkrabang",country:{name:"Thailand"}}},{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038UqSfQAK/Profile_Picture_2022-05-13T10:39:03.jpg",biography:"Dr. Muhammad Mohiuddin is an Associate Professor of International Business at Laval University, Canada. 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Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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