Tether mass properties for various materials (from Eqs. (4), (7) and (8)).
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"5793",leadTitle:null,fullTitle:"Novel Implications of Exosomes in Diagnosis and Treatment of Cancer and Infectious Diseases",title:"Novel Implications of Exosomes in Diagnosis and Treatment of Cancer and Infectious Diseases",subtitle:null,reviewType:"peer-reviewed",abstract:"The aim of this book is to provide an overview of the importance of exosomes in the biomedical field, which involves in novel implications of exosomes in diagnosis and treatment of cancer and infectious diseases. The book would definitely be an ideal source of scientific information of exosomes to researchers and scientists involved in biomedicine, biology, and other areas involving cancer and infectious diseases.",isbn:"978-953-51-3336-0",printIsbn:"978-953-51-3335-3",pdfIsbn:"978-953-51-4745-9",doi:"10.5772/65504",price:119,priceEur:129,priceUsd:155,slug:"novel-implications-of-exosomes-in-diagnosis-and-treatment-of-cancer-and-infectious-diseases",numberOfPages:192,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"24e328fe01c47071f2ea44b2608e824f",bookSignature:"Jin Wang",publishedDate:"July 12th 2017",coverURL:"https://cdn.intechopen.com/books/images_new/5793.jpg",numberOfDownloads:16282,numberOfWosCitations:15,numberOfCrossrefCitations:12,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:26,numberOfDimensionsCitationsByBook:2,hasAltmetrics:1,numberOfTotalCitations:53,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 26th 2016",dateEndSecondStepPublish:"November 10th 2016",dateEndThirdStepPublish:"February 2nd 2017",dateEndFourthStepPublish:"March 30th 2017",dateEndFifthStepPublish:"June 1st 2017",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"188127",title:"Prof.",name:"Jin",middleName:null,surname:"Wang",slug:"jin-wang",fullName:"Jin Wang",profilePictureURL:"https://mts.intechopen.com/storage/users/188127/images/5841_n.jpg",biography:"Professor Jin Wang is a PI at Shanghai Public Health Clinical Center, Fudan University, China. Dr. Wang has been working in the fields of cancer and infectious diseases. A major focus of his research is to develop novel early detection biomarkers of human cancers utilizing various state-of-the-art genomic technologies, and he has been able to identify several interesting candidate biomarkers of human pancreatic cancers and liver cancer. Dr. Wang has authored/coauthored 3 patents (U.S. WO Patent WO/2012/030,956; P.R. China Patent NO: 99113481.8) and over 30 SCI publications with a citation rate of over 1000. He has received the prestigious Anne Eastland Spears Fellowship Award in Gastrointestinal Cancer Research from the University of Texas, MD Anderson Cancer Center in the USA, and three independent fellowships from reputed institutions including NIH/NIDDK (USA). His laboratory conducts basic and translational research in the following areas: (1) development of novel early detection biomarkers of human gastrointestinal (GI) cancers and (2) pharmacologic ascorbic acid, all-trans retinoid acid, and ncRNAs for treatment of cancer and infectious diseases.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Fudan University",institutionURL:null,country:{name:"China"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"428",title:"Cancer Biology",slug:"biochemistry-genetics-and-molecular-biology-oncology-cancer-biology"}],chapters:[{id:"55850",title:"Novel Implications of Exosomes and lncRNAs in the Diagnosis and Treatment of Pancreatic Cancer",doi:"10.5772/intechopen.69510",slug:"novel-implications-of-exosomes-and-lncrnas-in-the-diagnosis-and-treatment-of-pancreatic-cancer",totalDownloads:1551,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Pancreatic cancer remains a leading cause of cancer-related deaths. Most patients are present with advanced stages of the disease at the time of diagnosis; thus, surgery, which is the best curative option for this malignancy, is no longer an effective treatment modality for affected individuals. As a likely source of “liquid biopsies,” exosomes, which are secreted by fusing intracellular multivesicular bodies with cell membranes, have relative stability and composition, allowing them to cover the entire range of cancer-related biomarkers, including cellular proteins, lipids, DNA, RNA, miRNA, and long non-coding RNAs (lncRNAs). To explore the early detection biomarkers of pancreatic cancer and to develop successful therapeutic intervention for this disease, assessing the implications of exosomes in pancreatic cancer patients is essential. In this chapter, we wish to focus on the possibility of using exosomes and lncRNAs in the clinical management of patients with pancreatic cancer. We will discuss the mechanisms of tumor formation under the exosomal action, demonstrate how circulating exosomes and lncRNAs have come into the research spotlight as likely biomarkers of pancreatic cancer, and discuss the applications of exosomes as transfer vectors in tumor therapeutics.",signatures:"Jin Wang, Xuan Zhang, Chunxia Ji, Lei Zhang, Yang Di, Wenhui Lou,\nXiaoyan Zhang and Jianqing Xu",downloadPdfUrl:"/chapter/pdf-download/55850",previewPdfUrl:"/chapter/pdf-preview/55850",authors:[{id:"188127",title:"Prof.",name:"Jin",surname:"Wang",slug:"jin-wang",fullName:"Jin Wang"}],corrections:null},{id:"55802",title:"Exploiting Exosomes for Differential Diagnosis of Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance",doi:"10.5772/intechopen.69398",slug:"exploiting-exosomes-for-differential-diagnosis-of-multiple-myeloma-and-monoclonal-gammopathy-of-unde",totalDownloads:1607,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Multiple myeloma (MM) is a plasma cell dyscrasia characterized by a clonal plasma cell proliferation. Usually, all MM are preceded by an asymptomatic premalignant stage termed monoclonal gammopathy of undetermined significance (MGUS). Differential diagnosis requires the evidence of end-organ damage, but recently new biomarkers are emerging to help clinicians to distinguish MM from the premalignant phase. Circulating exosomes in serum seem to be a powerful tool to be analyzed for liquid biopsy, and in this chapter, we show that MM and MGUS exosomes are different in concentration, biological activity, and biochemical markers. These differences seem to be related to the free light chains (FLCs) associated with exosomes and their propathogenic properties. The cellular processing FLC-decorated exosomes and their ability to activate proinflammatory mechanisms are different in MM and MGUS patients. These elements can be evaluated to create an innovative multiparameter panel to monitor MGUS to MM switching.",signatures:"Lucia Paolini, Giuseppe Di Noto, Andrea Zendrini, Paolo Bergese\nand Doris Ricotta",downloadPdfUrl:"/chapter/pdf-download/55802",previewPdfUrl:"/chapter/pdf-preview/55802",authors:[{id:"197307",title:"Dr.",name:"Lucia",surname:"Paolini",slug:"lucia-paolini",fullName:"Lucia Paolini"},{id:"198148",title:"Mr.",name:"Andrea",surname:"Zendrini",slug:"andrea-zendrini",fullName:"Andrea Zendrini"},{id:"198149",title:"Dr.",name:"Doris",surname:"Ricotta",slug:"doris-ricotta",fullName:"Doris Ricotta"},{id:"198151",title:"Prof.",name:"Paolo",surname:"Bergese",slug:"paolo-bergese",fullName:"Paolo Bergese"},{id:"198152",title:"Dr.",name:"Giuseppe",surname:"Di Noto",slug:"giuseppe-di-noto",fullName:"Giuseppe Di Noto"}],corrections:null},{id:"55901",title:"Animal Models in Exosomes Research: What the Future Holds",doi:"10.5772/intechopen.69449",slug:"animal-models-in-exosomes-research-what-the-future-holds",totalDownloads:2749,totalCrossrefCites:3,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Exosomes have been implicated in a wide range of pathological and nonpathological processes. Research on tumor-derived exosomes uncovered their role on major processes associated with disease progression. Uncontrolled cellular proliferation resulting in tumor growth, metastatic dissemination and modulation of the immune response, are only a few of the central pathological processes in which tumor-derived exosomes have been implicated. These in vivo studies rely on the administration of purified labeled exosomes from cell culture supernatants into circulation of animals or injections of genetically engineered cells that produce labeled exosomes. However, it is not clear that current available techniques actually translate the in vivo implications of exosomes in several biological processes. The variations seen when using different exosomes cell sources, the total amount of exosomes injected in mice and their route of administration as well as the fact that most studies are performed in immunodeficient animals, shows the difficulty to achieve conclusions which are biologically significant. Genetically engineered mouse models (GEMM) could be a promising approach to address the current technical limitations allowing tracing tumor-derived exosomes in a living organism. These models could enhance greatly our knowledge about exosomes in different fields of research, namely cancer.",signatures:"Bárbara Adem and Sónia A. Melo",downloadPdfUrl:"/chapter/pdf-download/55901",previewPdfUrl:"/chapter/pdf-preview/55901",authors:[{id:"196563",title:"Dr.",name:"Sonia",surname:"Melo",slug:"sonia-melo",fullName:"Sonia Melo"},{id:"197463",title:"M.Sc.",name:"Bárbara",surname:"Adem",slug:"barbara-adem",fullName:"Bárbara Adem"}],corrections:null},{id:"55760",title:"Exosomes and Their Role in Viral Infections",doi:"10.5772/intechopen.69397",slug:"exosomes-and-their-role-in-viral-infections",totalDownloads:2398,totalCrossrefCites:2,totalDimensionsCites:5,hasAltmetrics:1,abstract:"Exosomes are excretory nano-vesicles that are formed by the cell’s endocytic system and shed from the surface of almost all types of cells. These tiny extracellular vesicles, once thought to be “garbage bags for cells,” carry a wide variety of molecules of cellular origin, including proteins, lipids, and RNAs, that are selectively incorporated during the formation of exosomes. Exosomes are now known to play a central role in several important biological processes such as cellular communication, intercellular transfer of bioactive molecules, and immune modulation. Recent advances in the field have shown that a number of animal viruses can exploit the exosomal pathway by incorporating specific cellular or viral factors within exosomes, in order to modulate the cellular microenvironment and influence downstream processes such as host immunity and virus spread. In this chapter, we provide an overview of our current understanding of exosome biogenesis and how this normal physiological process is hijacked by some pathogenic viruses. Viral components that appear to be selectively incorporated into exosomes and the potential role of these exosomes in viral pathogenesis are discussed. Identifying viral signatures in exosomes and their mode of action is fundamental for any future diagnostic and therapeutic strategies for viral infections.",signatures:"Gulfaraz Khan, Waqar Ahmed and Pretty S. Philip",downloadPdfUrl:"/chapter/pdf-download/55760",previewPdfUrl:"/chapter/pdf-preview/55760",authors:[{id:"199889",title:"Prof.",name:"Gulfaraz",surname:"Khan",slug:"gulfaraz-khan",fullName:"Gulfaraz Khan"},{id:"201764",title:"Mr.",name:"Waqar",surname:"Ahmed",slug:"waqar-ahmed",fullName:"Waqar Ahmed"},{id:"201766",title:"Ms.",name:"Pretty",surname:"Philip",slug:"pretty-philip",fullName:"Pretty Philip"}],corrections:null},{id:"55727",title:"Exosomes as the Promising Biomarker for Epstein-Barr Virus (EBV)-Associated Cancers",doi:"10.5772/intechopen.69532",slug:"exosomes-as-the-promising-biomarker-for-epstein-barr-virus-ebv-associated-cancers",totalDownloads:1493,totalCrossrefCites:0,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Exosomes are microvesicles with sizes ranging from 50 to 150 nm. These small vesicles are known to morphologically and functionally resemble virus particles from human immunodeficiency virus type I (HIV-I) and human T-lymphotropic virus type I (HTLV-I). The function of exosomes is to mainly mediate cell-to-cell communication by exchanging various macromolecules including proteins, lipids and nucleic acids in diverse cellular processes. Due to its size and structural simplicity, the transfer of pathogenic or virulent cellular factors across the cells mediated by exosomes is more efficient, hence facilitating the dissemination of viral infections and cancer diseases. The pathogenic role of exosomes in various cancers such as lung and breast, and their potentials as biomarkers have been previously studied, yet limited information is known for Epstein-Barr virus (EBV)-associated cancers. In this chapter, we discuss current evidences that support the pathogenic roles of exosomes in EBV-related cancers and their potentials as biomarkers in cancer diagnostics and therapy response. Here, we also highlight the potential challenges in the development of exosome-based biomarkers for clinical application.",signatures:"Sin-Yeang Teow and Suat-Cheng Peh",downloadPdfUrl:"/chapter/pdf-download/55727",previewPdfUrl:"/chapter/pdf-preview/55727",authors:[{id:"196516",title:"Dr.",name:"Sin-Yeang",surname:"Teow",slug:"sin-yeang-teow",fullName:"Sin-Yeang Teow"},{id:"205188",title:"Prof.",name:"Suat-Cheng",surname:"Peh",slug:"suat-cheng-peh",fullName:"Suat-Cheng Peh"}],corrections:null},{id:"55695",title:"Mining Extracellular Vesicles for Clinically Relevant Noninvasive Diagnostic Biomarkers in Cancer",doi:"10.5772/intechopen.69406",slug:"mining-extracellular-vesicles-for-clinically-relevant-noninvasive-diagnostic-biomarkers-in-cancer",totalDownloads:1435,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:1,abstract:"Extracellular vesicles (EVs) are nanosized vesicles secreted by virtually all cell types into the extracellular milieu. EVs transport bioactive molecules between cells and play multifaceted roles in cell-to-cell communications and in the pathogenesis of various human diseases including cancer. EVs are currently a focus of intensive interest, mainly because they hold a wealth of biological information in the form of differentially expressed nucleic acids and proteins, including DNA and cancer-related mutated genes, microRNAs, and a variety of transcriptional factors. Both the mutational content and any differentially expressed RNA are highly stable in patient blood or urine because they are encapsulated in EVs. This protects them against nuclease activity, pH change, temperature fluctuations, and multiple free-thaw cycles. Therefore, EVs isolated from patient fluids may serve as an ideal source of liquid biopsy for mining cancer signatures through mutation screening and genetic profiling. However, the methods for obtaining pure and intact EVs from patient samples, as well as the optimized characterization of tumor-derived EVs are still not rigorously defined for routine clinical use. High-throughput genomic or proteomic platforms may aid in the identification of novel diagnostic and prognostic biomarkers that collectively could lead to cancer monitoring and improved patient outcome.",signatures:"Muhammad Nawaz, Farah Fatima and Jeremy A. Squire",downloadPdfUrl:"/chapter/pdf-download/55695",previewPdfUrl:"/chapter/pdf-preview/55695",authors:[{id:"199581",title:"Dr.",name:"Muhammad",surname:"Nawaz",slug:"muhammad-nawaz",fullName:"Muhammad Nawaz"},{id:"205753",title:"Dr.",name:"Farah",surname:"Fatima",slug:"farah-fatima",fullName:"Farah Fatima"},{id:"205754",title:"Dr.",name:"Jeremy",surname:"Squire",slug:"jeremy-squire",fullName:"Jeremy Squire"}],corrections:null},{id:"55962",title:"Microvesicles Released from Human Red Blood Cells: Properties and Potential Applications",doi:"10.5772/intechopen.69599",slug:"microvesicles-released-from-human-red-blood-cells-properties-and-potential-applications",totalDownloads:2052,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:1,abstract:"Microvesicles (MVs) are small spherical fragments of plasma membrane between 50 and 1000 nm in diameter. MVs arise through direct outward budding and fission of the plasma membrane. As almost all cells, human red blood cells (RBCs) are able to release MVs into extracellular environment under stimulating or storage conditions. Recently, it has been known that MVs not only play a role in homeostasis but also have diverse functions in cell-cell interactions and in the pathogenesis of diseases. In this chapter, the formation and release of MVs from human RBCs have been described. In addition, MVs have demonstrated to be potential vehicle for transport of nucleic acid and other molecules to the target cells. Although RBC-derived MVs are potential material for the development of delivery systems, it is still a great challenge to the clinical application. Future research should pay more attention to MVs as biological targets for diagnosis and practical therapeutics of cancer and other diseases.",signatures:"Duc Bach Nguyen, Thi Bich Thuy Ly and Ingolf Bernhardt",downloadPdfUrl:"/chapter/pdf-download/55962",previewPdfUrl:"/chapter/pdf-preview/55962",authors:[{id:"199869",title:"Dr.",name:"Duc Bach",surname:"Nguyen",slug:"duc-bach-nguyen",fullName:"Duc Bach Nguyen"},{id:"205404",title:"Dr.",name:"Thuy",surname:"Ly Thi Bich",slug:"thuy-ly-thi-bich",fullName:"Thuy Ly Thi Bich"},{id:"205405",title:"Prof.",name:"Ingolf",surname:"Bernhardt",slug:"ingolf-bernhardt",fullName:"Ingolf Bernhardt"}],corrections:null},{id:"55861",title:"Exosome Isolation: Is There an Optimal Method with Regard to Diagnosis or Treatment?",doi:"10.5772/intechopen.69407",slug:"exosome-isolation-is-there-an-optimal-method-with-regard-to-diagnosis-or-treatment-",totalDownloads:2998,totalCrossrefCites:2,totalDimensionsCites:5,hasAltmetrics:0,abstract:"Extracellular vesicles (EV) gained considerable interest in recent years as both diagnostic tools and templates for therapeutic applications. EVs carry a number of cell-specific markers which gave researchers the opportunity of employing them as liquid biopsies causing no discomfort to patients. On the other hand, they are very exciting candidates for drug delivery due to their eobiotic origin, physicochemical and size characteristics. Isolation of EVs is performed by several strategies, having advantages and disatvantages over each other. As such, the method of EV isolation and in particular exosome isolation determines the quality and purity of obtained vesicles. In this chapter, extracellular vesicle isolation methods are evaluated with regard to their further use. Methods such as ultracentrifugation with different modifications, size exclusion chromatography, ultrafiltration, affinity and precipitation are compared with respect to the yield efficacy and purity of isolates. Furthermore, the advantages and disadvantages of different methods according to the purpose of use are revealed. Recent progress and remaining challenges in the isolation of EVs with regard to diagnosis and treatment is reviewed and discussed. In order to select the most suitable method researchers should clearly define purity, yield, quantity and quality requirements for exosomes, and consider disadvantages of distinct isolation methods.",signatures:"Mustafa Kotmakçı and Gülşah Erel Akbaba",downloadPdfUrl:"/chapter/pdf-download/55861",previewPdfUrl:"/chapter/pdf-preview/55861",authors:[{id:"196627",title:"Ph.D.",name:"Mustafa",surname:"Kotmakçı",slug:"mustafa-kotmakci",fullName:"Mustafa Kotmakçı"},{id:"199212",title:"MSc.",name:"Gülşah",surname:"Erel Akbaba",slug:"gulsah-erel-akbaba",fullName:"Gülşah Erel Akbaba"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6313",title:"Neoplasm",subtitle:null,isOpenForSubmission:!1,hash:"dfea745f8ae5593e6dfc35d9e621291f",slug:"neoplasm",bookSignature:"Hafiz Naveed Shahzad",coverURL:"https://cdn.intechopen.com/books/images_new/6313.jpg",editedByType:"Edited 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Konstantin Tsiolkovsky, credited with the concept of multi-stage rocket vehicles, also proposed the orbital tower. Much later Yuri Artsutanov inverted this idea to suggest a geostationary satellite with a counterweight and a tether extending to the Earth’s surface. This so called ‘space elevator’ was first published in 1960 in Komsomolskaya Pravda and later discovered independently in the US when the term ‘skyhook’ was coined [1]. The structure was shown to be stable against the effects of lunar tidal forces and payload motions, and functions by extracting energy from Earth rotation [2]. The problem is that no known material has sufficient strength to construct a space elevator in Earth orbit.
\nDifficulties with the space elevator led to the proposal of the asynchronous orbital skyhook [3]. (The original concept was credited to John McCarthy at Stanford.) This is an extended orbital structure that rotates so that each end periodically comes to a low altitude and velocity, at which instants the system is easy to access. Initial studies advocated configurations that place a low demand on the tether material properties, as this was thought to be the principal challenge. To replace energy lost during launch it was proposed that the skyhook be used to return a similar quantity of material from orbit to Earth.
\nDetailed studies of the asynchronous skyhook [4, 5] addressed engineering aspects of the tether and docking mechanism. They proposed a set of configurations in which access is provided by a hypersonic vehicle operating at a speed of at least 3.1 km/s (Mach 10). This high speed of the access vehicle reduces the skyhook rotation rate and so places less stress on the tether material.
\nHypersonic flight technology is not yet capable of providing routine access to the high Mach number regime. By contrast, several reusable vehicles are available that provide access to suborbital flight trajectories using combinations of air-breathing and rocket propulsion [6, 7]. High strength fiber technology has also made substantial progress with the incorporation of carbon nanotubes into the molecular structure [8]. This suggests a need to review the orbital skyhook concept with a focus on configurations that allow low speed access. It is also necessary to explore different approaches to energy replenishment that do not require access to a repository of orbiting material.
\nSection 2 reviews the skyhook concept and estimates the parameters of a practical launch system. Expressions for the skyhook mass properties are obtained in Section 3 for the case where centripetal force is the dominant source of tension. The dynamics is modeled in Section 4 assuming the structure remains linear, with the tether mass properties represented by a compact object at the mass centroid. Electric propulsion is proposed as a mechanism for energy replenishment in Section 5, and the feasibility of supplying propellant for the thrusters is explored. Section 6 describes the advantages of a skyhook launch system for future planetary science missions, and Section 7 summarizes the main results.
\nAn orbital skyhook launch system involves three phases, each exploiting a different physical process. It begins with the delivery of a payload by suborbital vehicle. Docking occurs at one of the skyhook endpoints when it is near minimum altitude and velocity. The suborbital vehicle is required to attain only a small fraction of the energy needed for orbit, and does not need to operate in a hypersonic flight regime. It can therefore employ mature airframe and propulsion technologies, making it easier to design for efficiency and reusability.
\nThe second phase is momentum transfer from the skyhook to the payload [9]. After docking the payload gains energy as the skyhook rotates, reaching a maximum after half a cycle. If the payload is not released energy transfers back to the skyhook in the second half of the cycle as it returns to minimum energy. By selecting when the payload is released, it can be placed into an elliptical orbit or on an escape trajectory. Note that if the payload is released at a subsequent minimum energy point, the skyhook energy and orbit are left unaffected. This means the vehicle is transported around the Earth at orbital velocity, with the only energy cost being that of gaining access to the skyhook.
\nIn the third phase energy drawn from the skyhook during launch must be replenished. If the payload mass is small relative to the total system mass, the orbital perturbation is also small. In this case the structure remains above the atmosphere through subsequent rotations, and energy replenishment may occur over an extended period. Electric propulsion is proposed for this purpose. It provides a small thrust with a large specific impulse, and therefore high propellant efficiency. Propellant can be delivered with the payload to supply thrusters at the skyhook endpoints, but it will be shown that a better approach is to apply thrust at the skyhook mass centroid.
\nOf interest here are skyhook configurations that offer low speed access. Ideally the endpoint speed should match the orbital velocity relative to Earth’s surface. In addition, acceleration during launch must not be excessive. For a skyhook in a circular equatorial orbit with radius \n
Here \n
Specifying the endpoint velocity and acceleration yields two implicit equations for the skyhook parameters. With a nominal orbital radius of 8000 km the skyhook length is small enough to apply the limit \n
One of the skyhook endpoints is at minimum energy when the structure is oriented radially. This state occurs with a period \n
The skyhook configurations of interest here have an endpoint speed near orbital velocity to allow access at low energy. The high rotation rate means tension is mainly due to centripetal force, with the field gradient contribution being negligible.
\nConsider a symmetric skyhook comprising two equal masses \n
Substituting \n
Here \n
The tether mass \n
Evaluating the integrals and simplifying:
\nThe limit \n
These expressions for the skyhook mass properties indicate the dependence on tether material properties, and provide key parameters for dynamical modeling.
\nAn important feature of a tether is the taper factor, the ratio of maximum to minimum cross-section area. A tether constructed from low strength material has a large taper factor, indicating its impracticality. The nominal skyhook described above with a carbon fiber tether has a taper factor of 237, in which case the diameter at the centroid is about 15 times that the end points. If the tether had the properties of carbon nanotubes the taper factor reduces to 3.3. The properties of any future tether material are likely to fall within these bounds.
\nTable 1 indicates the mass properties of the nominal skyhook for several tether materials. Notionally high strength materials like steel and diamond are excluded by the very large taper factor. Aramid fibers like Kevlar are possible but the total mass is large. The strongest carbon fiber offers a solution with a skyhook mass about 4600 times the endpoint mass. If materials with still greater tensile strength become available, such as by incorporating carbon nanotubes or colossal carbon tubes into the tether material, the taper factor and skyhook mass can be much smaller.
\nMaterial | \nDensity (kg/m3) | \nStrength (MPa) | \n\n\n | \nTaper Factor | \nMass ( | \nMoment ( | \n
---|---|---|---|---|---|---|
Steel 2800 | \n8000 | \n2693 | \n67.7 | \n1.2 × 1025 | \n2.9 × 1027 | \n3.1 × 1023 | \n
Diamond | \n3500 | \n2800 | \n26.7 | \n4.1 × 1011 | \n3.9 × 1013 | \n2.7 × 1010 | \n
Aramid fiber | \n1440 | \n3757 | \n8.2 | \n3629 | \n1.05 × 105 | \n783.4 | \n
Zylon (PBO) | \n1560 | \n5800 | \n5.75 | \n315 | \n6421 | \n96.1 | \n
Carbon fiber (T1100S) | \n1790 | \n7000 | \n5.47 | \n237 | \n4596 | \n75.8 | \n
Carbon nanotube | \n1340 | \n63,000 | \n0.45 | \n1.58 | \n5.46 | \n5.06 | \n
Colossal carbon tube | \n116 | \n7000 | \n0.35 | \n1.43 | \n1.70 | \n5.93 | \n
For the skyhook configuration described here the endpoint mass is regarded as the maximum payload capability. This assumes the endpoint mass may be replaced by a docking mechanism of negligible mass to capture the payload. Engineering margins have not been included in this analysis, but the nominal configuration is a ‘worst case’ in the sense that skyhook rotation is specified to allow access at zero velocity relative to the Earth. If the access vehicle provides a horizontal velocity component the rotation rate is smaller, in which case the taper factor and skyhook mass are also decreased.
\nSkyhook length is a significant factor in the dynamics because field strength is not uniform across the structure. This differs from most problems in astrodynamics where the object of interest is small compared to the field gradient length scale, or the system can be simplified by assuming spherical symmetry.
\nHere the skyhook is assumed to behave as a rigid body, kept in tension by the rotation and experiencing no stretching or bending. The validity of these assumptions depends on the tether material properties, but they are sufficient for the present purpose. The structure is expected to remain linear due to the large centripetal restoring force that counters any bending.
\nThe equations of motion of a rigid body are typically obtained by a Lagrangian method using the mass properties. This formulation ignores the field gradient effect, which is important for skyhook dynamics. To see this note that the skyhook structure experiences a moment due to the two arms being subject to different field strengths according to their proximity to Earth. If the skyhook were treated as a single compact object this behavior would not be represented.
\nThe skyhook system is modeled here as three objects connected by tethers of fixed length \n
Skyhook geometry with the tether mass and moment of inertia represented by a compact object at the mass centroid.
The system state is described by a six element vector comprising the skyhook centroid location \n
The gravitational force on each mass is projected through the centroid to obtain the net radial and azimuthal forces, and onto the normal for the torque:
\nHere \n
The skyhook equations of motion are then:
\nEvaluating the vector dot products and re-arranging:
\nThe skyhook trajectory was obtained by numerical solution of these equations of motion for the nominal parameters. The endpoint altitude and ground track speed are shown in Figure 2. Note that the minimum energy point occurs at zero ground track speed at an altitude of 532 km. The specific energy of a stationary object at this altitude is about 5% of one in orbit. The configuration could be altered to allow access at a lower altitude, but it may then incur an unacceptable risk of collision with satellites in low Earth orbit.
\nAltitude (dark) and ground track speed (light) of a skyhook endpoint.
During launch momentum transfers from the skyhook to the payload, perturbing the skyhook orbit into an ellipse. This perturbation is small if the skyhook mass is much greater than the payload mass, as is true for most tether materials. If the tether material is sufficiently strong the skyhook mass can be small enough for the orbital perturbation to be significant. This can be overcome by placing ballast mass at the centroid.
\nAfter launch it is necessary to replenish the skyhook energy and circularize the orbit. If the orbital eccentricity is small there is no interaction between the skyhook and the atmosphere, so this may occur over many orbits. Electric thrusters are proposed as a suitable technology for maintaining the skyhook orbit. They produce thrust with a high specific impulse, and therefore utilize propellant very efficiently.
\nThe preferred location to apply thrust is the skyhook centroid. A force at this point maximizes energy transfer, the rate of work being the product of the thrust and orbital velocity
Electric propulsion has been developed for tasks that require a small thrust with high specific impulse. Examples include orbital transfer and deep space missions, for which ion thrusters are the preferred technology. Energy replenishment requires a high specific impulse and sufficient thrust to limit the replenishment time. A magnetoplasmadynamic (MPD) motor is best suited for this purpose. MPD thruster technology is developmental, but their performance can be inferred from experimental demonstrators.
\nAn MPD thruster creates an electric current in plasma in the presence of a magnetic field. The field may be generated externally by coils or intrinsically by the current itself. In either case Lorentz force acts on the plasma and expels it at high velocity. Laboratory MPD thrusters have demonstrated 5 N of thrust with a mass flow rate of 60 mg/s [10]. The MPD thruster is a compact and robust device, but it operates most efficiently at high power levels in the order of 1 MW. It is estimated that a practical MPD thruster could achieve a thrust of 2.5–25 N with an efflux velocity of 15–60 km/s [11].
\nA thruster with efflux velocity \n
The ratio \n
The quantity of propellant needed for energy replenishment is much smaller than the payload mass, but it must be delivered to the skyhook centroid. This can be achieved by having the skyhook launch a transport vehicle into an elliptical orbit, after which it uses conventional propulsion systems to perform an orbital transfer maneuver and rendezvous with the centroid. The analysis concludes by demonstrating that it is possible to deliver propellant efficiently to the skyhook centroid.
\nSkyhook endpoint kinematics is characterized by near uniform circular motion for both the orbit and the rotation. The velocity may be determined by adding the two rotational velocities as illustrated in Figure 3.
\nSkyhook orbital geometry and payload velocity at detachment.
The triangle in the figure is fully specified, so all angles can be expressed in terms of the skyhook parameters and endpoint radial coordinate. If the payload detaches at a speed less than escape velocity it enters an elliptical orbit with a periapsis, apoapsis and eccentricity given by:
\nThe transition to a circular orbit can be achieved with a bi-elliptical transfer maneuver [12]. This involves a prograde impulse at apoapsis to increase the periapsis, followed by a retrograde impulse at periapsis to circularize the orbit. The maneuver can be implemented with a series of small impulses over several orbits, but the single orbit procedure serves to illustrate the process. The velocity changes at apoapsis and periapsis are given by:
\nThe initial orbit depends on the skyhook configuration and its orientation when the payload is released. For the nominal skyhook most orbits have a periapsis smaller than Earth radius, necessitating an impulse during the first orbit to increase the periapsis to avoid reentry into the atmosphere. Only a small impulse is needed for this purpose, which can be provided by a conventional rocket. The rest of the orbital transfer maneuver can be achieved efficiently by employing low thrust electric propulsion over multiple orbits.
\nTo illustrate the process consider a vehicle that is released from the skyhook at an orientation angle \n
Planetary science and space-based astronomy demand increasingly complex infrastructure, and the high cost of launch limits the scope of experiments. A more efficient launch process would allow larger vehicles to be constructed and more ambitious experiments to be undertaken. The orbital skyhook is a fully reusable launch system with high propellant efficiency, and which can be constructed using current materials technology. It can deliver payloads directly to Earth orbit, or to a trajectory for transfer to lunar orbit.
\nAccess to orbit is the first stage of any planetary science mission. Typically a launch vehicle places the spacecraft and its propulsion system into orbit to await the appropriate time to commence interplanetary transfer. Because of the high launch cost a low energy trajectory is usually employed. This restricts the available launch window and increases the transit time. With a more efficient launch process it would be possible to use a larger and more capable propulsion system, and thus to allow a less efficient trajectory. This flexibility could be used to deliver a larger experimental payload, conduct more frequent missions, or achieve a reduced transit time.
\nAn emerging ambition of national space programs is a return to the moon, often extending to the establishment of permanent bases on the moon and in lunar orbit. Planetary science is unlikely to be a primary driver of this initiative, but it stands to be a significant beneficiary. For astronomy the moon offers a low gravity environment free of atmospheric and ionospheric effects, Earth based radio emissions, and interference due to the large number of satellites in low Earth orbit. A skyhook launch system that provides efficient transport to the moon would allow astronomical experiments with far greater sensitivity than is possible with terrestrial instruments.
\nLunar orbit is also a favorable location from which to launch planetary science missions. It is close enough for easy access but at a significantly higher energy than low Earth orbit. Complex modules constructed on Earth can be delivered efficiently by the skyhook, while fuel and water can be supplied from the moon at a much lower energy cost. Vehicles returning from the moon could dock with the skyhook as it approaches a minimum energy state, using it to decelerate in preparation for a low speed re-entry while also returning energy to the system. The use of an orbital skyhook for efficient transport to and from the moon is therefore a key enabler of future planetary science missions.
\nThe orbital skyhook derives its advantage principally from using different propulsion technologies in the various physical regimes experienced during a launch. The payload gains energy by momentum transfer from the skyhook, with this energy being later repaid over an extended period. This overcomes the large energy threshold associated with a launch by drawing from a repository and replenishing it efficiently by electric propulsion.
\nThe focus here is on skyhook configurations that allow access at a low speed relative to the Earth. These can be accessed much more easily, but necessarily rotate rapidly to counter the orbital velocity. This means centripetal force dominates the tension, making it is possible to obtain simple expressions for the skyhook mass properties. With a carbon fiber tether the skyhook mass is about 4600 times greater than the endpoint mass, which represents the maximum launch payload. The skyhook mass can be greatly reduced if a stronger tether material were to become available.
\nBecause the skyhook is an extended structure in a non-uniform field, it is subject to forces and torques that vary with orientation. To represent this behavior the skyhook was modeled as a linear structure comprising two masses connected by an inelastic massive tether. The tether mass properties were represented as a compact object at the mass centroid, and a Newtonian formulation used to obtain the equations of motion. These equations were solved numerically to confirm their validity and investigate the dynamics.
\nSkyhook energy lost during a launch can be replenished by an electric thruster acting at the centroid. The MPD motor is a suitable propulsion technology for this purpose, and was shown to be capable of achieving energy replenishment in a reasonable time with high propellant efficiency. This result holds regardless of the size and efficiency of the propulsion system because the energy transfer process depends only on the efflux velocity and mass flow rate.
\nApplying thrust at the centroid is beneficial because the structure is most robust at this point and the local acceleration is near zero. It is necessary, however, to transport propellant to the centroid and a mechanism is proposed to achieve this. A transport vehicle is launched by the skyhook into an elliptical orbit, after which it executes an orbital transfer maneuver to rendezvous with the centroid. This process can be accomplished with a high propellant efficiency using available propulsion systems.
\nThe endpoint mass represents the maximum skyhook payload capacity. This envisages the endpoint carrying a docking mechanism of negligible mass that can accept the payload. The skyhook mass scales linearly with the endpoint mass, and so also with the maximum payload. When an initial system has been established it can be used to launch material to add to the structure to increase the payload capacity. This process is likely to be limited by the access vehicle payload capacity, at which point there is no benefit in further increasing the skyhook mass.
\nPlanetary science requires increasingly elaborate experiments. Improved launch efficiency allows more ambitious missions to be undertaken, with larger propulsion systems to deliver more massive experiments to the planet of interest with sufficient propellant for soft landing on the planet surface. The renewed enthusiasm of national space programs for a return to the moon could provide the incentive for construction of an orbital skyhook to provide efficient transport to and from the moon. This would make it possible to conduct astronomical observations from the moon with a sensitivity far greater than is possible from Earth, and to exploit lunar orbit as a base for launching future planetary science missions.
\nThe community prevalence of ADHD worldwide has been estimated at being between 3% and 7% [1, 2]. Yet, the rate of administrative prevalence (number of individuals with a clinical diagnosis) in the UK is approximately 1% [3] and varies between 0.3% and 2.5% across the globe [4], demonstrating a wide difference from the estimated community prevalence. While it is difficult to assess the exact administrative prevalence across the world, these figures imply that ADHD is underdiagnosed and under-treated in many countries [4, 5]. For instance, in the UK, reports suggest that only 0.73% of children and 0.06% of adults currently receive ADHD medication [6]. Even when patients have received a diagnosis, medication use varies widely across European countries [7] and treatment is often low. A greater understanding of the reasons behind these discrepancies is required [8].
The access to care pathway varies widely across countries. For example, in the US, ADHD is generally managed by private PCPs. However, in countries including much of Africa, Asia, Central and South America and parts of southern Europe, ADHD rates of recognition remain low, and resources available for treatment tend to be mainly focused on tertiary centres rather than in primary care settings [9]. In the UK, diagnosis and treatment are managed in secondary care services following a referral from PCPs. While this chapter discusses the generic role and understanding of PCPs in ADHD care, the focus is primarily on care pathways similar to the one in the UK.
Different factors have been identified concerning the difficulties in accessing care, for example, parents’ lack of recognition and lack of help-seeking [10], the complexity of the ADHD care pathway or primary care physicians’1 lack of recognition [8, 12].
Although many factors influence service utilisation, the first port of call tends to be PCPs who act as gatekeepers in many countries. To receive an ADHD assessment and diagnosis, patients are often referred to specialist healthcare services (psychiatrists, paediatricians, etc.) through their PCPs [13]. Once a diagnosis has been made, PCPs can be involved in supporting the management of children with ADHD and in liaising with parents and specialists. It is, therefore, primordial that PCPs have a comprehensive understanding of ADHD.
To further understand PCPs’ awareness of ADHD, a few systematic reviews [8, 14, 15] have summarised the factors influencing their understanding. The main findings from these studies highlighted lack of knowledge, recognition and training as critical barriers to PCPs’ understanding of ADHD. Misconceptions about ADHD in primary care were also observed as well as other barriers, such as the complexity of the multidisciplinary approach of the pathway to care and the lack of services, were also identified by more recent studies [12, 16]. However, the main recurring theme from these reviews and research was the lack of training on ADHD and the need for tailored training programs for PCPs.
Informed by this evidence, an online intervention aimed to increase PCPs’ awareness and knowledge was developed. This online psycho-education intervention was co-produced with PCPs to address the gaps in ADHD knowledge and training, reduce misconceptions and clarify the role of the PCPs within the ADHD pathway to care. The development process involved multiple steps, including developing an online resource, producing patients’ testimony videos and experts’ videos, collating and editing relevant information and a thorough review process. The evaluation of this intervention demonstrated that this online resource significantly improved PCPs’ knowledge and attitudes towards ADHD, reduced their misconceptions and impacted their practice. It also highlighted that the intervention was acceptable and feasible in both controlled and real-life settings. Finally, the important contribution and the implication of these findings are discussed. Considerations over the development process, the impact on primary care and implications for future research and clinical settings are also presented.
The pathway to care for ADHD is complex and varies widely across countries [4]. In the UK for instance, care pathways challenges are often generated by the wide variation of service provisions across different areas. Healthcare services are different from one locality to another, and commissioning decisions vary across the country.
Many guidelines on ADHD have been developed to standardise ADHD care. European guidelines were developed to further ADHD understanding and standard care across Europe [17], guiding healthcare professionals on acceptable healthcare standards and clarifying the different steps in ADHD care from identification to treatment. These steps are described as recognition, identification and referral, diagnosis and management. However, the timeframe and specificities of processes within these different steps are ambiguous.
While published guidelines aim to inform and influence the different steps in accessing care for ADHD, little is known about how well they are implemented into local clinical practice. The main difficulty with published guidelines is understanding the complex implementation in day-to-day practice. For instance, the referral and diagnosis process in European countries such as the UK involves referral to services that may or may not be available in different regions [18, 19], for example for adult services. A European review [20] confirmed a lack of adult services across Europe and highlighted the limited experience and knowledge of healthcare professionals on adult ADHD, posing an issue on who is then responsible for treatment management.
Issues with services and care pathways directly impact the referral or diagnostic process. For instance, it creates longer waiting times to receive access to care [21]. In this European review, Fridman and colleagues established that the UK had the longest waiting times, with the meantime from the first PCP visit to receiving a diagnosis of 18.3 months [21]. They also highlighted that a majority of caregivers (35%) experienced substantial difficulties in obtaining an ADHD diagnosis, lack of sufficient resources and gaps in support from healthcare providers being significant challenges in accessing care. Additionally, Kovshoff and colleagues [22] found that clinicians perceived the assessment and diagnosis decision-making processes to be inherently complex, requiring a great deal of time and experience.
The care pathway for ADHD is very complex and very few countries have clear diagnosis and treatment pathways. While guidelines aim to improve access to care by facilitating healthcare professionals’ decision-making, many barriers impact their application into practice. These barriers reflect the complexity of a multiple-level approach, significantly affecting the quality of care for adults and children with ADHD and practice by healthcare professionals.
While healthcare professionals’ roles in the ADHD pathway vary across countries and regions, in the majority of cases, PCPs act as gatekeepers. After initial identification, PCPs will refer patients to specialist services, where individuals can gain an assessment, diagnosis and access to treatment if required. PCPs are also at times responsible for handling prescriptions of medication once treatment has been initiated. In most countries, PCPs are not responsible for diagnosing ADHD and initializing treatment.
Many complexities arise from PCPs being able to correctly refer to and identify ADHD. First and foremost, PCPs are under intense pressure with unprecedented workloads [23, 24] and only have a short scheduled time to see their patients. The identification process is complex and includes evaluating the patient’s behaviour in different settings and over a period of time, it often requires multiple appointments. It is, therefore, a demanding process that cannot be routinely conducted during a standard ten-minute consultation.
Secondly, discrimination (such as sex and gender) can sometimes happen in the identification of ADHD in primary care [25, 26], especially for adults. Adults presenting to their PCPs might have developed other complex issues (such as depression or anxiety) due to untreated ADHD in childhood, making it very difficult for PCPs to unpick [27] and adult ADHD can also be somewhat controversial with stigmas still strongly present [28] and beliefs over the continuation of the disorder into adulthood mixed [29, 30]. Similarly, gender bias is strongly prominent, and girls tend to be identified less than boys [25, 31]. However, girls tend to show more inattentive traits than boys, who tend to show more hyperactivity traits [32], which makes it more complex to identify in a brief PCP consultation.
Finally, other barriers at these early stages have been identified. Sayal, Goodman and Ford [10] for instance highlighted that one of these barriers was the limited presentation of these problems to primary care. PCPs may hold negative feelings towards ADHD and see the ADHD label as a negative diagnostic label [8, 14] and many PCPs report low levels of confidence in the recognition and management of ADHD [33]. Moreover, Hinshaw and colleagues [9] highlighted significant cultural and historical differences between countries in the belief of ADHD as a valid disorder, demonstrating a substantial variance in attitudes and knowledge.
PCPs hold a gatekeeping role in accessing ADHD care, and their understanding and awareness of the disorder are of utmost importance in facilitating patients’ access to a diagnosis and treatment. Unmanaged and untreated ADHD results in long-term impairments in many domains [34]. In adulthood, these issues are associated with higher criminal behaviour rates, loss of work, addiction, suicidality and failed relationships [35] demonstrating that untreated ADHD can have substantial economic and social burdens [36]. There is, therefore, a strong need for early detection and diagnosis and gaining timely access to care is of great importance.
Previous studies have highlighted that many barriers to recognition exist in primary care settings (such as misconceptions, lack of education, or lack of resources), preventing access to care for individuals with ADHD and potentially impacting diagnosis rates. Three recent systematic reviews have summarised the current evidence based on primary care knowledge and pathways [8, 14, 15] and the key themes were identified as a strong need for education and training, presence of misconceptions and stigma, time and resource constraints with recognition and management and treatment [14]. Many misconceptions were expressed including disbeliefs regarding the validity of ADHD as a disorder as well as strong misconceptions about medications and the role of the parents [15]. Wider determinants, continuity of care and identification of needs also contributed to the complexity of understanding ADHD in primary care settings [8]. These findings suggest many interacting factors are at play in the recognition of ADHD by primary care practitioners with a strong recurring theme of a significant need for better education on ADHD.
Previous research has demonstrated that accessing care can be influenced by the knowledge and attitudes of health professionals [37], with limited PCPs recognition being a key barrier [8, 14]. In many countries, very few PCPs have received formal training on ADHD [14, 15] with lack of education about the disorder being a key component of their lack of confidence [33]. Primary care professionals also often feel inadequately equipped to manage or recognise adult ADHD [38]. Interviews with PCPs and other stakeholders [12] described the ADHD pathway and the role of primary care as an intricate process. Many factors impacted this process, such as lack of services, limited PCPs’ recognition and knowledge, and challenging communication between multiple stakeholders. Therefore limited recognition in primary care could be due to the lack of accurate knowledge and understanding of the disorder, scepticism, misconceptions and many stigmas still associated with ADHD [8, 14, 15]. Interventions to improve access [8] and training for PCPs [12] have been highlighted as a strong need and present a potential solution to the lack of ADHD knowledge in primary care settings.
Establishing the right training program is important for busy professionals such as PCPs. While an ideal training program does not exist key elements have been identified to promote successful learning, namely, accessibility and co-production. Their use of online training has significantly increased over the last two decades [39, 40], with a US study reporting an increase of physicians taking part in online learning activities from 605,410 to 4,365,014 between 2002 and 2008 alone [39]. Online training offers many advantages for PCPs such as being easily accessible anywhere and at times that work around their busy schedules. Online training has been shown to improve PCPs’ practice as well as knowledge [41]. However, to promote uptake of these training programs, they must meet PCPs’ needs and are deemed feasible and acceptable. Interventions tailored to address identified barriers have been shown to improve professional practise [42]. Co-produced research offers the opportunity to enhance this. Embedding co-production activities into research and training development is a way to promote responsible innovation and to ensure that the research outputs are relevant, engaging and desirable for the end-users [43, 44].
Previous studies have established key barriers and themes in understanding ADHD in primary care. In order to address issues around knowledge and confidence of PCPs, an online intervention was developed, informed by these findings. Focusing on increasing knowledge and reducing misconceptions about ADHD, an online psycho-educational intervention was developed over nine months. At first, a concrete plan for the development of the intervention was put in place to improve PCPs’ knowledge of ADHD and optimise appropriate referrals. This training was co-developed with PCPs as involving end-users enhances their clinical utility and impacts routine clinical practice.
The process followed a step-wise, co-production approach [45]. The three steps process was informed by previous studies [8, 14, 15] highlighting the relevant topics to be included in the intervention. Educational videos and online materials were developed, and workshops and reviews were then conducted with PCPs, leading to further refinement of the content and, subsequently, the final intervention.
The first step in the development process was to aggregate evidence-based knowledge on PCPs’ understanding of ADHD to gain a more specific idea of the gaps to be addressed. Careful considerations of the barriers highlighted by the systematic reviews [8, 14, 15] and the issues highlighted by other recent studies needed to be given [12, 16, 46]. As many barriers were established, deciding which barriers could be addressed in the intervention and which were beyond the realm of the project was essential. For instance, the barrier of lack of knowledge could be easily addressed through the training but barriers such as lack of resources or issues with services could not be addressed.
The second step in the development process involved filming a video of children with ADHD talking about their experiences. An adult video had previously been produced by a local adult ADHD clinic (Video1https://vimeo.com/64790626). This compelling video highlighted the importance of including patients’ experiences of ADHD to convey a greater understanding of the impact it has in everyday life. Permission to use this video within the remit of this thesis was granted, and it was decided to create a similar one with children (Video2 https://vimeo.com/306201810). The same filming company was used to ensure coherence between the two videos and these two short videos were included in the intervention.
The next step in the intervention development process was to create the online resource. For this, and after researching different options, a team specialising in health e-learning resources (HELM) was selected. A specific development programme was followed according to their own tested methods, which involved key researchers developing the content of the intervention and HELM creating the learning platform. This last step involved different steps. Firstly, workshops were conducted with PCPs to develop a tailored resource that will meet their needs. Suggestions from PCPs were then integrated and implemented into the intervention, to the best of the researchers’ abilities. For instance, PCPs suggested including videos of clinical and academic experts as well as the patients’ videos. Four new videos reflecting different expertise were subsequently added. Secondly, a review process from expert academics and PCPs insured that the final product developed was appropriately targeted at PCPs and that the content was adequate. Finally, the intervention was reviewed and endorsed by the Royal College of GPs, the national professional membership body for family doctors in the UK and overseas.
The involvement of PCPs greatly improved the development of this online intervention and the constant adaptation of the intervention ensured that the PCPs’ needs and preferences were met.
The flowchart below (Figure 1) represents the development process of the intervention.
Developmental process of the intervention.
The complete online intervention consists of two 25-minute modules undertaken sequentially2. The two modules follow a similar format of text on one side and interactive activities on the other side of the screen. Different interactive activities were included such as drag and drop games, patient testimonies or videos.
“Understanding Attention Deficit Hyperactivity Disorder”.
This first module introduces the different aspects of ADHD. Following a brief description of ADHD epidemiology and neuroscience, the core three symptoms are discussed and illustrated by real-life examples. This module also details other symptoms, common misconceptions and the long-term impacts ADHD has on children and adults.
“The role of General Practitioners in ADHD diagnosis and management”.
The second module introduces in more detail the ADHD care pathway and the PCP’s role. Clarifying the PCPs gatekeeping role and specific UK care pathways, this module also details identification, treatment options and the clinical benefits of having good knowledge of ADHD in practice.
Both modules included an “ADHD toolkit” which contained various downloadable forms to support PCPs (such as screening tools, strategies or useful websites).
Following the development of the online training, the usability and efficacy of this intervention were assessed through three clear steps. First, a usability study evaluated PCPs’ experiences of interacting with the intervention and any further changes that might need to be implemented. Secondly, a pilot randomised control trial (RCT) gauged the intervention’s feasibility and explored if it could successfully increase PCPs’ awareness and understanding of ADHD. Thirdly, PCPs’ experiences on whether this intervention impacted their practice were explored through interviews conducted a few months after the intervention.
This preliminary study [45] was conducted to assess the intervention’s acceptability, feasibility and accessibility through a questionnaire. The participants’ evaluative feedback was positive towards the content, design and usability of the online intervention, and little improvement was suggested. The usability study demonstrated that the content of the intervention was accessible, suitable, engaging and informative, validating the co-development approach taken.
Pilot RCT.
A pilot RCT [47] was then conducted to assess the efficacy of the online ADHD training intervention. Participants were blindly randomised to two groups (control or intervention) and had to complete a set of questionnaires evaluating their ADHD confidence, knowledge and attitude at three time points (pre and post-intervention and two-week follow-up). PCPs’ confidence, knowledge and attitude significantly increased after viewing the online training while misconceptions decreased. These findings remained at the two-week follow-up (Figure 2).
Results of ADHD knowledge questionnaire (KADDS, [
Participants from the intervention group were invited to take part in follow-up interviews and a survey after the intervention [47]. The findings from these studies showed that the training had a strong impact on PCPs’ attitudes, knowledge, awareness and practice. PCPs explained that not only were their patients positively impacted by improving access to care but members of the community also (such as colleagues or families). While it was anticipated that PCPs’ knowledge and practice could change from taking part in this study, the acknowledgement of this broader, holistic impact was unexpected.
These three studies allowed the online intervention to be thoroughly assessed. The usability study established the accessibility of the intervention, whilst the pilot RCT and interviews demonstrated its efficacy and its positive impacts on knowledge and practice. These results demonstrate that the online ADHD intervention is highly accessible, usable and efficient. Lack of identification and recognition of ADHD in PCPs can be remediated by PCPs completing a short 45-minute online course, in turn improving patients’ access to care. It indicates that a short online intervention can increase PCPs’ understanding and approach towards ADHD, improving patients’ access to care by impacting their practice.
Previous studies highlighted earlier in this chapter have demonstrated that some of the significant barriers to PCPs’ understanding and management of ADHD are their lack of training, knowledge and presence of misconception. These evaluation studies have shown that a short online education resource can be easily implemented and can address these gaps while also impacting practice. The pilot RCT study [47] (with over 68% of GPs having never received any training on ADHD) and others [4, 38] have highlighted the lack of ADHD training for PCPs. The pilot RCT showed no difference was observed between participants who had and those who had not had ADHD training, indicating that current training is ad-hoc and not effective. This supports previous findings on the strong need for adequate intervention for healthcare professionals, most importantly PCPs [4, 8]. This intervention is, therefore, timely in addressing these gaps.
The main goal of the online resource described in this chapter was to increase PCPs’ understanding and awareness of ADHD. The efficacy of this intervention highlights many positive implications both in terms of future research and in terms of clinical practice.
The choice of online training was a pragmatic one, supported by the PCPs in the co-production phase. Online training is increasingly relied on for healthcare CPD [39] as an accessible learning mode. PCPs expressed their preferences in developing an online resource rather than an app or face-to-face workshops through the development workshops. Similarly to previous studies on online healthcare educational programmes [49, 50], this intervention shows a significant improvement in knowledge, confidence and practice while reducing misconceptions. It is also essential to highlight the benefits of conducting a co-production development process. Tailored online training has been shown to improve PCPs’ knowledge and practice [42, 50]. The evaluation of the PCPs’ intervention supports these findings and highlights the necessity and benefits of developing tailored, co-produced online training for PCPs.
Previous studies presented earlier in this chapter have highlighted significant barriers to accessing care such as lack of ADHD knowledge and lack of recognition [(8, 14, 15], see Section 2.4 for a concise summary). Increasing knowledge and understanding of ADHD from PCPs can lead to many positive outcomes. As such, the online intervention presented aims to:
Increase support given in primary care for ADHD
Increase PCPs’ identification of ADHD
Increase referral to appropriate services
Improve patient’s experiences of seeking a diagnosis by receiving better support and more accurate referrals
Facilitate the diagnosis process, which could lead to reduced waiting lists.
Increasing PCPs’ awareness and identification of ADHD may lead to many clinical benefits by directly impacting patients, their access to care, quality of management and long-term quality of life. Families of patients would also be impacted as the burden of caring for undiagnosed or untreated issues might lessen. Finally, other healthcare professionals would benefit from a better understanding of ADHD from PCPs facilitating better communication and clearer pathways to care.
However, it is important to note that the potential benefits come with ethical considerations. Increased identification and increased referrals might impact demands on specialist services. As such services can often be overstretched [51, 52, 53], increased referrals will directly impact these services. Implications such as long waiting lists and stricter triage systems need to be considered as they could negatively impact the patient.
Future research, both in terms of healthcare research and in other subjects such as education or even policymaking would greatly benefit from the findings of this project.
For instance, a longitudinal evaluation of the long-term impact and implementation of the intervention would strengthen these findings and demonstrate the potential long-term benefits of such interventions. Further studies exploring the participants’ retention of ADHD knowledge and its implementation within their practice in the long term, would greatly inform a more comprehensive implementation of the online training.
The co-developmental process also demonstrated its benefits on interventions’ development. A lot was learned from the PCPs’ involvement in this process, and the final resource was positively different from what was originally proposed without their input, considerably shaping the research. Therefore, future intervention development projects should strongly consider this co-production aspect and the inclusion of end-users in the development process throughout the different stages.
Furthermore, this online intervention could be adapted for other professional groups who experience ADHD in their daily lives (such as other healthcare professionals parents or teachers). Including other stakeholders in the training would allow for a comprehensive overview of the ADHD pathway and clarify the role of all key stakeholders. An adaptation for parents would also support their journey through the care pathway. Parents often wait a very long time for a diagnosis [21] and often have no resources or information on ADHD during that time. A short online resource could increase their understanding and signpost them to support while on the waiting list. Studies have also shown that teachers face similar barriers to PCPs in understanding and knowledge of ADHD [54, 55, 56]. Therefore, an adapted resource for teachers would help address these gaps and facilitate an overall clearer pathway to care for ADHD.
Finally, a better understanding and identification of ADHD will create many wider impacts beyond clinical practice and research. Schools would benefit from having diagnosed children as they can implement adapted educational strategies to manage difficult behaviours, directly impacting school and pupils’ performance and the classroom learning environment. The long-term costs of ADHD can be severe, such as significant academic underachievement and educational problems [57, 58, 59], increased prevalence of depression and anxiety [60, 61], higher rates of offending behaviour and imprisonment [62, 63], divorce [64], driving accidents [65, 66], unemployment [67, 68], suicide [69, 70] and other mental health issues [71]. These considerable risks are attenuated when ADHD is diagnosed, as diagnosis facilitates access to care or support [72]. By gaining early diagnosis and treatment, these factors can be reduced, directly impacting society overall, government bodies and the national healthcare systems.
This chapter presented the latest evidence of the understanding of ADHD in primary care, establishing the barriers and gaps in PCPs’ understanding of ADHD and presenting an innovative tailored psycho-education intervention that addresses these gaps. The efficiency of this resource, its impact and its implementation are also presented.
Barriers to PCPs’ understanding and gaps in their knowledge were identified through evidence-based research and the findings from these studies demonstrate a presence of limited ADHD knowledge and a need for education in primary care.
In order to address these gaps, an online psycho-education intervention was co-produced with PCPs to address the gaps in knowledge and training, reduce misconceptions and clarify the role of PCPs in the ADHD pathway to care. This development process involved multiple steps in order to ensure the most adequate intervention was developed.
This intervention was evaluated through different methods. This evaluation demonstrated that the intervention significantly improved PCPs’ knowledge and attitudes towards ADHD, reduced their misconceptions and impacted their practice. It also highlighted that the intervention was acceptable and feasible. The implications for clinical practice and research are discussed.
It is important to note some limitations of this intervention. Completing the intervention takes approximately 45 minutes; while this is not very long, in PCPs’ day to day practice, this might still be too long. The smartphone layout of the intervention is not as easy to navigate and the videos and the interactive activities have a stronger impact if viewed on a computer. Finally, the second module on the role of the PCP is specific to UK pathways. While the first module on Understanding ADHD is internationally relevant, the second has many country-specific limitations as it aimed to clarify the role of general practitioners (PCPs) within the UK system. Countries with similar pathways to care, however, might also benefit from this resource.
In conclusion, has PCPs’ understanding of ADHD can be very minimal, the development and delivery of a targeted online educational resource demonstrate both a strong need for adequate PCP training and the efficacy of such resources. The use of this intervention benefits many individuals, principally PCPs but also patients, their families and other healthcare providers.
The research studies presented in this chapter were greatly guided by the expertise of Prof. Kapil Sayal, Prof. David Daley, Dr. Charlotte Hall and Dr. Elvira Perez from the University of Nottingham and Dr. Corrie Smith from Lancashire NHS Trust. Their input and feedback were extremely valuable in conducting a thorough research project and implementable intervention. This work was also generously funded by the ESRC.
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Conventional methods for the removal of metal ions such as chemical precipitation and membrane filtration are extremely expensive when treating large amounts of water, inefficient at low concentrations of metal (incomplete metal removal) and generate large quantities of sludge and other toxic products that require careful disposal. Biosorption and bioaccumulation are ecofriendly alternatives. These alternative methods have advantages over conventional methods. Abundant natural materials like microbial biomass, agro-wastes, and industrial byproducts have been suggested as potential biosorbents for heavy metal removal due to the presence of metal-binding functional groups. Biosorption is influenced by various process parameters such as pH, temperature, initial concentration of the metal ions, biosorbent dose, and speed of agitation. Also, the biomass can be modified by physical and chemical treatment before use. 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Such technique is based on in situ microorganism production which plays three major roles: (i) maintenance of water quality, by the uptake of nitrogen compounds generating in situ microbial protein; (ii) nutrition, increasing culture feasibility by reducing feed conversion ratio (FCR) and a decrease of feed costs; and (iii) competition with pathogens. The aggregates (bioflocs) are a rich protein-lipid natural source of food available in situ 24 hours per day due to a complex interaction between organic matter, physical substrate, and large range of microorganisms. This natural productivity plays an important role recycling nutrients and maintaining the water quality. 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So, air and water can potentially become polluted everywhere. Little is known about changes in pollution rates. The increase in water-related diseases provides a real assessment of the degree of pollution in the environment. This chapter summarizes water quality parameters from an ecological perspective not only for humans but also for other living things. According to its quality, water can be classified into four types. Those four water quality types are discussed through an extensive review of their important common attributes including physical, chemical, and biological parameters. These water quality parameters are reviewed in terms of definition, sources, impacts, effects, and measuring methods.",book:{id:"7718",slug:"water-quality-science-assessments-and-policy",title:"Water Quality",fullTitle:"Water Quality - Science, Assessments and Policy"},signatures:"Nayla Hassan Omer",authors:null},{id:"58138",title:"Water Pollution: Effects, Prevention, and Climatic Impact",slug:"water-pollution-effects-prevention-and-climatic-impact",totalDownloads:21554,totalCrossrefCites:18,totalDimensionsCites:38,abstract:"The stress on our water environment as a result of increased industrialization, which aids urbanization, is becoming very high thus reducing the availability of clean water. Polluted water is of great concern to the aquatic organism, plants, humans, and climate and indeed alters the ecosystem. The preservation of our water environment, which is embedded in sustainable development, must be well driven by all sectors. While effective wastewater treatment has the tendency of salvaging the water environment, integration of environmental policies into the actor firms core objectives coupled with continuous periodical enlightenment on the present and future consequences of environmental/water pollution will greatly assist in conserving the water environment.",book:{id:"6157",slug:"water-challenges-of-an-urbanizing-world",title:"Water Challenges of an Urbanizing World",fullTitle:"Water Challenges of an Urbanizing World"},signatures:"Inyinbor Adejumoke A., Adebesin Babatunde O., Oluyori Abimbola\nP., Adelani-Akande Tabitha A., Dada Adewumi O. and Oreofe Toyin\nA.",authors:[{id:"101570",title:"MSc.",name:"Babatunde Olufemi",middleName:null,surname:"Adebesin",slug:"babatunde-olufemi-adebesin",fullName:"Babatunde Olufemi Adebesin"},{id:"187738",title:"Dr.",name:"Adejumoke",middleName:"Abosede",surname:"Inyinbor",slug:"adejumoke-inyinbor",fullName:"Adejumoke Inyinbor"},{id:"188818",title:"Dr.",name:"Abimbola",middleName:null,surname:"Oluyori",slug:"abimbola-oluyori",fullName:"Abimbola Oluyori"},{id:"188819",title:"Mrs.",name:"Tabitha",middleName:null,surname:"Adelani-Akande",slug:"tabitha-adelani-akande",fullName:"Tabitha Adelani-Akande"},{id:"208501",title:"Dr.",name:"Adewumi",middleName:null,surname:"Dada",slug:"adewumi-dada",fullName:"Adewumi Dada"},{id:"208502",title:"Ms.",name:"Toyin",middleName:null,surname:"Oreofe",slug:"toyin-oreofe",fullName:"Toyin Oreofe"}]},{id:"45422",title:"Urban Waterfront Regenerations",slug:"urban-waterfront-regenerations",totalDownloads:14203,totalCrossrefCites:4,totalDimensionsCites:12,abstract:null,book:{id:"3560",slug:"advances-in-landscape-architecture",title:"Advances in Landscape Architecture",fullTitle:"Advances in Landscape Architecture"},signatures:"Umut Pekin Timur",authors:[{id:"165480",title:"Dr.",name:"Umut",middleName:null,surname:"Pekin Timur",slug:"umut-pekin-timur",fullName:"Umut Pekin Timur"}]},{id:"24941",title:"Tsunami in Makran Region and Its Effect on the Persian Gulf",slug:"tsunami-in-makran-region-and-its-effect-on-the-persian-gulf",totalDownloads:7575,totalCrossrefCites:4,totalDimensionsCites:7,abstract:null,book:{id:"406",slug:"tsunami-a-growing-disaster",title:"Tsunami",fullTitle:"Tsunami - A Growing Disaster"},signatures:"Mohammad Mokhtari",authors:[{id:"52451",title:"Dr.",name:"Mohammad",middleName:null,surname:"Mokhtari",slug:"mohammad-mokhtari",fullName:"Mohammad Mokhtari"}]},{id:"66307",title:"Bio-hydrogen and Methane Production from Lignocellulosic Materials",slug:"bio-hydrogen-and-methane-production-from-lignocellulosic-materials",totalDownloads:2953,totalCrossrefCites:6,totalDimensionsCites:8,abstract:"This chapter covers the information on bio-hydrogen and methane production from lignocellulosic materials. Pretreatment methods of lignocellulosic materials and the factors affecting bio-hydrogen production, both dark- and photo-fermentation, and methane production are addressed. Last but not least, the processes for bio-hydrogen and methane production from lignocellulosic materials are discussed.",book:{id:"7608",slug:"biomass-for-bioenergy-recent-trends-and-future-challenges",title:"Biomass for Bioenergy",fullTitle:"Biomass for Bioenergy - Recent Trends and Future Challenges"},signatures:"Apilak Salakkam, Pensri Plangklang, Sureewan Sittijunda, Mallika Boonmee Kongkeitkajorn, Siriporn Lunprom and Alissara Reungsang",authors:null}],onlineFirstChaptersFilter:{topicId:"12",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82465",title:"Agroforestry: An Approach for Sustainability and Climate Mitigation",slug:"agroforestry-an-approach-for-sustainability-and-climate-mitigation",totalDownloads:6,totalDimensionsCites:0,doi:"10.5772/intechopen.105406",abstract:"Agroforestry Systems (AFS), or the association of trees with crops (or animals), is a strategy for land management and use that allows production within the sustainable development: (a) environmentally (production environmentally harmonic); (b) technically (integrating existing resources on the farm); (c) economically (increase in production), and (d) socially (equality of duties and opportunities, quality of life of the family group). As an intentional integration of trees or shrubs with crop and animal production, this practice makes environmental, economic, and social benefits to farmers. Given that there is a set of definitions, rather than a single definition of Agroforestry (AF) and AFS, it is justified to explore the historical evolution and the minimum coincidences of criteria to define them and apply them in the recovery of degraded areas. Knowing how to classify AFS allows us to indicate which type or group of AFS is suitable for a particular area with its characteristics. The greatest benefit that AFS can bring to degraded or sloping areas lies in their ability to combine soil conservation with productive functions. In other words, AF is arborizing agriculture and animal production to obtain more benefits including climate change adaptation and mitigation by ecosystem services.",book:{id:"11663",title:"Vegetation Dynamics, Changing Ecosystems and Human Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11663.jpg"},signatures:"Ricardo O. Russo"},{id:"82754",title:"Impact of Revegetation on Ecological Restoration of a Constructed Soil in a Coal Mining in Southern Brazil",slug:"impact-of-revegetation-on-ecological-restoration-of-a-constructed-soil-in-a-coal-mining-in-southern-",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.105895",abstract:"The main problems in the constructed soils are the generation of acid mine drainage promoted by the presence of coal debris in the overburden layer and the compaction of the topsoil promoted by the machine traffic when the material used in the overburden cover is more clayey. This book chapter aimed to show an overview of the impact of more than a decade of revegetation with different perennial grasses on the chemical, physical, and biological quality of constructed soil after coal mining. The study was carried out in a coal mining area, located in southern Brazil. The soil was constructed in early 2003 and the perennial grasses, Hemarthria altissima; Paspalum notatum cv. Pensacola; Cynodon dactylon cv Tifton; and Urochloa brizantha; were implanted in November/December 2003. In 11.5, 17.6 and 18 years of revegetation soil samples were collected and the chemical, physical, and biological attributes were determined. Our results show that liming is an important practice in the restoration of these strongly anthropized soils because this positively impacts the plants’ development, facilitating the roots system expansion. Biological attributes such as soil fauna and the microorganism’s population are the attributes that possibly takes longer to establish itself in these areas.",book:{id:"11663",title:"Vegetation Dynamics, Changing Ecosystems and Human Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11663.jpg"},signatures:"Lizete Stumpf, Maria Bertaso De Garcia Fernandez, Pablo Miguel, Luiz Fernando Spinelli Pinto, Ryan Noremberg Schubert, Luís Carlos Iuñes de Oliveira Filho, Tania Hipolito Montiel, Lucas Da Silva Barbosa, Jeferson Diego Leidemer and Thábata Barbosa Duarte"},{id:"82936",title:"Soil Degradation Processes Linked to Long-Term Forest-Type Damage",slug:"soil-degradation-processes-linked-to-long-term-forest-type-damage",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.106390",abstract:"Forest degradation impairs ability of the whole landscape adaptation to environmental change. The impacts of forest degradation on landscape are caused by a self-organization decline. At the present time, the self-organization decline was largely due to nitrogen deposition and deforestation which exacerbated impacts of climate change. Nevertheless, forest degradation processes are either reversible or irreversible. Irreversible forest degradation begins with soil damage. In this paper, we present processes of forest soil degradation in relation to vulnerability of regulation adaptability on global environmental change. The regulatory forest capabilities were indicated through soil organic matter sequestration dynamics. We devided the degradation processes into quantitative and qualitative damages of physical or chemical soil properties. Quantitative soil degradation includes irreversible loss of an earth’s body after claim, erosion or desertification, while qualitative degradation consists of predominantly reversible consequences after soil disintegration, leaching, acidification, salinization and intoxication. As a result of deforestation, the forest soil vulnerability is spreading through quantitative degradation replacing hitherto predominantly qualitative changes under continuous vegetation cover. Increasing needs to natural resources using and accompanying waste pollution destroy soil self-organization through biodiversity loss, simplification in functional links among living forms and substance losses from ecosystem. We concluded that subsequent irreversible changes in ecosystem self-organization cause a change of biome potential natural vegetation and the land usability decrease.",book:{id:"11457",title:"Forest Degradation Under Global Change",coverURL:"https://cdn.intechopen.com/books/images_new/11457.jpg"},signatures:"Pavel Samec, Aleš Kučera and Gabriela Tomášová"},{id:"82828",title:"Vegetation and Avifauna Distribution in the Serengeti National Park",slug:"vegetation-and-avifauna-distribution-in-the-serengeti-national-park",totalDownloads:6,totalDimensionsCites:0,doi:"10.5772/intechopen.106165",abstract:"In order to examine the bird species changes within different vegetation structures, the variations were compared between Commiphora-dominated vegetations with those of Vachellia tortilis and Vachellia robusta-dominated vegetations, and also compared the birds of grassland with those of Vachellia drepanolobium and Vachellia seyal-dominated vegetations. This study was conducted between February 2010 and April 2012. A total of 40 plots of 100 m × 100 m were established. Nonparametric Mann-Whitney U-test was used to examine differences in bird species between vegetations. Species richness estimates were obtained using the Species Diversity and Richness. A total of 171 bird species representing 103 genera, 12 orders, and 54 families were recorded. We found differences in bird species distribution whereby V. tortilis has higher bird species richness (102 species), abundance, and diversity when compared with Commiphora with 66 species and V. robusta with 59 species. These results suggest that variations in bird species abundance, diversity, and distribution could be attributed to differences in the structural diversity of vegetation. Therefore it is important to maintain different types of vegetation by keeping the frequency of fire to a minimum and prescribed fire should be employed and encouraged to control wildfire and so maintain a diversity of vegetation and birds community.",book:{id:"11663",title:"Vegetation Dynamics, Changing Ecosystems and Human Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11663.jpg"},signatures:"Ally K. Nkwabi and Pius Y. Kavana"},{id:"82808",title:"Climate Change and Anthropogenic Impacts on the Ecosystem of the Transgressive Mud Coastal Region of Bight of Benin, Nigeria",slug:"climate-change-and-anthropogenic-impacts-on-the-ecosystem-of-the-transgressive-mud-coastal-region-of",totalDownloads:8,totalDimensionsCites:0,doi:"10.5772/intechopen.105760",abstract:"The transgressive mud coastal area of Bight of Benin is a muddy coastal complex that lies east of the Barrier/lagoon coast and stretches to the Benin River in the northwestern flank of the Niger Delta Nigeria. It constitutes a fragile buffer zone between the tranquil waters of the swamps and the menacing waves of the Atlantic Ocean. Extensive breaching of this narrow coastal plain results in massive incursion of the sea into the inland swamps with serious implications for national security and the economy. Climate change impacts from the results of meteorological information of the regions shows a gradual degradation in the past 30 years. Temperature, rainfall and humidity increase annually depict climate change, resulting from uncontrolled exploitation of natural resources is rapidly pushing the region towards ecological disasters. The ecosystem is very unique being the only transgressive mud coastal area of the Gulf of Guinea. The chapter describes the geomorphology, tidal hydrology, relief/drainage, topography, climate/meteorology, vegetation, economic characteristics, anthropogenic activities and their impacts on the ecosystem.",book:{id:"11663",title:"Vegetation Dynamics, Changing Ecosystems and Human Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11663.jpg"},signatures:"Patrick O. Ayeku"},{id:"82697",title:"Analyzing the Evolution of Land-Use Changes Related to Vegetation, in the Galicia Region, Spain: From 1990 to 2018",slug:"analyzing-the-evolution-of-land-use-changes-related-to-vegetation-in-the-galicia-region-spain-from-1",totalDownloads:6,totalDimensionsCites:0,doi:"10.5772/intechopen.106015",abstract:"Considering the complex dynamics, patterns, and particularities that the Galicia region present—e.g., the fragility, shown to achieve sustainable development and growth—a study that analyzes the Land-Use related to the vegetation of this region is seen as pivotal to identifying barriers and opportunities for long-term sustainable development. Using GIS (Geographic Information Systems), the present chapter enables us to identify the dynamics and patterns of the evolution of the Land-Use Changes related to vegetation in the Galicia Region from 1990 to 2018 (years 1990, 2000, 2012, and 2018 using CORINE (Coordination of Information on the Environment) data). This study permits us to reinforce that the Land-Use Changes related to vegetation in the Galicia Region have undergone multiple changes—marked by increasing and decreasing periods. Also, can be considered a surveying baseline for the comparative analysis of similar works for different Land-Use Changes related to vegetation trends in Europe or worldwide. Land-Use Changes related to vegetation studies are reliable tools to evaluate the human activities and footprint of proposed strategies and policies in a territory. This chapter also enables us to understand that the main actors should design development policies to protect, preserve and conserve these incomparable landscapes, environments, ecosystems, and the region as a whole.",book:{id:"11663",title:"Vegetation Dynamics, Changing Ecosystems and Human Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11663.jpg"},signatures:"Sérgio Lousada and José Manuel Naranjo Gómez"}],onlineFirstChaptersTotal:77},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:141,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:"2753-6580",scope:"