% yield of desired products (4-8a,b,c).
\r\n\tThis book chapter’s main theme will be focused on transmission dynamics, pathogenesis, mechanisms of host interaction and response, epigenetics and markers, molecular diagnosis, RNA interacting proteins, RNA binding proteins, advanced development of tools for diagnosis, possible development of concepts for vaccines and anti drugs for RNA viruses, immunological mechanisms, treatment, prevention and control.
\r\n\t
Reinforcement learners interact with their environment and use their experience to choose or avoid certain actions based on the observed consequences. Actions that led to satisfactory outcomes (i.e. outcomes that met or exceeded aspirations) in the past tend to be repeated in the future, whereas choices that led to unsatisfactory experiences are avoided. The empirical study of reinforcement learning dates back to Thorndike’s animal experiments on instrumental learning at the end of the 19th century (Thorndike 1898). The results of these experiments were formalised in the well known ‘Law of Effect’, which is nowadays one of the most robust properties of learning in the experimental psychology literature:
\n\t\t\t\n\t\t\t\t
Nowadays there is little doubt that reinforcement learning is an important aspect of much learning in most animal species, including many phylogenetically very distant from vertebrates (e.g. earthworms (Maier & Schneirla, 1964) and fruit flies (Wustmann, 1996)). Thus, it is not surprising that reinforcement learning –being one of the most widespread adaptation mechanisms in nature– has attracted the attention of many scientists and engineers for decades. This interest has led to the formulation of various models of reinforcement learning and –when feasible– to the theoretical analysis of their dynamics. In particular, this chapter characterises the dynamics of one of the best known stochastic models of reinforcement learning (Bush & Mosteller, 1955) when applied to decision problems of strategy (i.e. games).
\n\t\t\tThe following section is devoted to explaining in detail the context of application of our theoretical analysis, i.e. 2-player 2-strategy games. Section 3 is a brief review of various models of reinforcement learning that have been studied in strategic contexts. Section 4 presents the Bush-Mosteller reinforcement learning algorithm. Section 5 describes two types of critical points that are especially relevant for the dynamics of the process: self-reinforcing-equilibria (SREs) and self-correcting-equilibria (SCEs). Sections 6 and 7 detail the relevance of these equilibria. Section 8 analyses the robustness of the model to “trembling-hands” noise and, finally, section 9 presents the conclusions of this chapter. The reader can replicate all the simulation runs reported in this chapter using an applet available at http://www.luis.izquierdo.name/papers/rl-book; we have also placed the source code used to create every figure in this chapter at the same web address.
\n\t\tAt the heart of any learning algorithm we always find the problem of choice: learning is about making better decisions. At the most elementary level, decision problems can be classified according to the factors that may influence the outcome of the problem. Following that criterion we can distinguish, in ascending order of generality, the following categories (Colman, 1995):
\n\t\t\tIndividual decision-making problems of
Individual decision-making problems under
Individual decision-making problems under
Decision problems of
Decision problems under
Problems of skill have been extensively studied in several branches of mathematics. In decision-making under risk, compelling solutions have been derived using the theory of probability and expected utility theory. Expected utility theory, however, has not been so successful in the study of decision-making under uncertainty and strategic decision-making, which is the competence of game theory. Finally, understandably so, the formal study of decision problems under ignorance has not developed much.
\n\t\t\tIn this chapter we formally study social interactions that can be meaningfully modelled as decision problems of strategy and, as such, using game theory as a framework. Game theory is a branch of mathematics devoted to the formal analysis of decision making in social interactions where the outcome depends on the decisions made by potentially several individuals. A game is a mathematical abstraction of a social interaction where (Colman, 1995):
\n\t\t\tthere are two or more decision makers, called
each player has a choice of two or more ways of acting, called actions or (
the players have well-defined preferences among the possible outcomes (Hargreaves Heap & Varoufakis, 1995). Thus,
Normal form or payoff matrix of a 2-player, 2-strategy game.
A normal (or strategic form) game can be defined using a function that assigns a payoff to each player for every possible combination of actions. For games with only two players this function is commonly represented using a matrix (see Fig. 1). The example shown in Fig. 1 is a 2-player 2-strategy game: there are two players (player 1 and player 2), each of whom must select one out of two possible (pure) strategies. Player 1 can choose Up or Down, and player 2 simultaneously decides between Left or Right. The payoffs obtained by each player are represented in the corresponding cell of the matrix. Player 1 obtains the first payoff in the cell (coloured in red) and player 2 gets the second (coloured in blue). As an example, if player 1 selects Down and player 2 selects Left, then player 1 gets a payoff of 4 and player 2 obtains a payoff of 0. This chapter deals with 2×2 (2-player 2-strategy) games, which can be represented using a matrix like the one shown in Fig. 1.
\n\t\t\tGame theory is a useful framework to accurately and formally describe interdependent decision-making processes. Furthermore, it also provides a collection of solution concepts that narrow the set of expected outcomes in such processes. The most widespread solution concept in game theory is the Nash equilibrium, which is a set of strategies, one for each player, such that no player, knowing the strategy of the other(s), could improve her expected payoff by unilaterally changing her own strategy (e.g. the unique Nash equilibrium of the game represented in Fig. 1 is the combination of strategies Down-Right). The Nash equilibrium has been tremendously influential in the social sciences, especially in economics, partly because it can be interpreted in a great number of meaningful and useful ways (Holt & Roth, 2004). Unfortunately, as a prediction tool, the concept is formally valid only when analysing games played by rational players with common knowledge of rationality Common knowledge of rationality means that every player assumes that all players are instrumentally rational, and that all players are aware of other players’ rationality-related assumptions (this produces an infinite recursion of shared assumptions).
In strategic contexts in general, empirical evidence suggests that reinforcement learning is most plausible in animals with imperfect reasoning abilities or in human subjects who have no information beyond the payoff they receive and may not even be aware of the strategic nature of the situation (Duffy, 2005; Camerer, 2003; Bendor et al., 2001a; Roth & Erev, 1995; Mookherjee & Sopher, 1994). In the context of experimental game theory with human subjects, several authors have used simple models of reinforcement learning to successfully explain and predict behaviour in a wide range of games (McAllister, 1991; Roth & Erev, 1995; Mookherjee & Sopher, 1994; Mookherjee & Sopher, 1997; Chen & Tang, 1998; Erev & Roth, 1998; Erev et al., 1999). In general, the various models of reinforcement learning that have been applied to strategic contexts tend to differ in the following, somewhat interrelated, features:
\n\t\t\tWhether learning slows down or not, i.e. whether the model accounts for the ‘Power Law of Practice’ (e.g. Erev & Roth (1998) vs. Börgers & Sarin (1997)).
\n\t\t\tWhether the model allows for avoidance behaviour in addition to approach behaviour (e.g. Bendor et al. (2001b) vs. Erev & Roth (1998)). Approach behaviour is the tendency to repeat the associated choices after receiving a positive stimulus; avoidance behaviour is the tendency to avoid the associated actions after receiving a negative stimulus (one that does not satisfy the player). Models that allow for negative stimuli tend to define an aspiration level against which achieved payoffs are evaluated. This aspiration level may be fixed or vary endogenously (Bendor et al., 2001a; Bendor et al., 2001b).
\n\t\t\tWhether “forgetting” is considered, i.e. whether recent observations weigh more than distant ones (Erev & Roth, 1998; Rustichini, 1999; Beggs, 2005).
\n\t\t\tWhether the model imposes inertia – a positive bias in favour of the most recently selected action (Bendor et al., 2001a; Bendor et al., 2001b).
\n\t\t\tLaslier et al. (2001) present a more formal comparison of various reinforcement learning models. Each of the features above can have important implications for the behaviour of the particular model under consideration and for the mathematical methods that are adequate for its analysis. For example, when learning slows down, theoretical results from the theory of stochastic approximation (Benveniste et al., 1990; Kushner & Yin, 1997) and from the theory of urn models can often be applied (e.g. Ianni, 2001; Hopkins & Posch, 2005; Beggs, 2005), whereas if the learning rate is constant, results from the theory of distance diminishing models (Norman, 1968; Norman, 1972) tend to be more useful (e.g. Börgers & Sarin, 1997; Bendor et al., 2001b; Izquierdo et al., 2007). Similarly, imposing inertia facilitates the analysis to a great extent, since it often ensures that a positive stimulus will be followed by an increase in the probability weight on the most recently selected action at some minimal geometric rate (Bendor et al., 2001b).
\n\t\t\tTwo of the simplest and most popular models of reinforcement learning in the game theory literature are the Erev-Roth (ER) model (Roth & Erev, 1995; Erev & Roth, 1998) and the Bush-Mosteller (BM) model (Bush & Mosteller, 1955). Both models are stochastic: players’ strategies are probabilities or propensities to take each of their possible actions. In the ER model, playing one action always increases the probability of playing that action again (i.e. only positive stimulus are considered), and the sensitivity of players’ strategies to a new outcome decreases as the game advances (Power Law of Practice). On the other hand, the BM model is an aspiration-based reinforcement learning model where negative stimuli are possible and learning does not fade with time.
\n\t\t\tA special case of the BM model where all stimuli are positive was originally considered by Cross (1973), and analysed by Börgers & Sarin (1997). In this chapter we characterise the dynamics of the BM model in 2×2 games where aspiration levels are fixed, but not necessarily below the lowest payoff (i.e. negative stimuli are possible). The dynamics of this model were initially explored by Macy & Flache (2002) and Flache & Macy (2002) in 2×2 social dilemma games using computer simulation, and their work was formalised and extended for general 2×2 games by Izquierdo et al. (2007). This chapter follows closely the work conducted by Izquierdo et al. (in press), who analysed the BM model using a combination of computer simulation experiments and theoretical results. Most of the theoretical results used in this chapter derive from Izquierdo et al. (2007).
\n\t\tThe model we analyse here is an elaboration of a conventional Bush-Mosteller (1955) stochastic learning model for binary choice. In this model, players decide what action to select stochastically: each player’s strategy is defined by the probability of undertaking each of the two actions available to them. After every player has selected an action according to their probabilities, every player receives the corresponding payoff and revises her strategy. The revision of strategies takes place following a reinforcement learning approach: players increase their probability of undertaking a certain action if it led to payoffs above their aspiration level, and decrease this probability otherwise. When learning, players in the BM model use only information concerning their own past choices and payoffs, and ignore all the information regarding the payoffs and choices of their counterparts.
\n\t\t\tMore precisely, let \n\t\t\t\t
In the BM model, strategy updating takes place in two steps. First, after outcome \n\t\t\t\t
\n\t\t\t\t
where \n\t\t\t\t
\n\t\t\t\t
where \n\t\t\t\t
In the general case, a 2×2 BM model parameterisation requires specifying both players’ payoff function
The following notation will be useful: A parameterised model will be denoted S, for System. Let
\n\t\t\t\tMacy & Flache (2002) observed and described two types of attractors that govern the dynamics of the BM model: self-reinforcing equilibria (SRE), and self-correcting equilibria (SCE). These two concepts are not equilibria in the static sense of the word, but strategy profiles which act as attractors that pull the dynamics of the simulation towards them. The original concepts of SRE and SCE were later formalised and refined by Izquierdo et al. (2007).
\n\t\t\tSREs are absorbing states of the system (i.e. states
The definition of the other type of attractor, namely the SCE, is related to the expected motion function of the system. The Expected Motion (EM) of a system S in state
where {CC, CD, DC, DD} represent the four possible outcomes that may occur.
\n\t\t\tFor instance, for a Prisoner’s Dilemma parameterised as [ 4, 3, 1, 0 | 2 |
This Expected Motion function is represented by the arrows shown in figure 2.
\n\t\t\tConsider now differential equation (1), which is the continuous time limit approximation of the system’s expected motion:
\n\t\t\tor, equivalently,
\n\t\t\tExpected motion of the system in a Prisoner’s Dilemma game parameterised as [ 4, 3, 1, 0 | 2 | 2−4]2, together with a sample simulation run (1000 iterations). The arrows represent the expected motion for various states of the system; the numbered balls show the state of the system after the indicated number of iterations in the sample run. The background is coloured using the norm of the expected motion. For any other learning rate the size of the arrows (i.e. the norm of the expected motion) would vary but their direction would be preserved.
Thus, for the Prisoner’s Dilemma parameterised as [ 4, 3, 1, 0 | 2 |
Some trajectories of this differential equation are shown in figure 3. The expected motion at any point
Trajectories in the phase plane of the differential equation corresponding to the Prisoner’s Dilemma game parameterised as [ 4, 3, 1, 0 | 2 |
An SCE of a system S is an asymptotically stable critical point (Mohler, 1991) of differential equation (1) (Izquierdo et al., 2007). Roughly speaking this means that all trajectories in the phase plane of Eq. (1) that at some instant are sufficiently close to the SCE will approach the SCE as the parameter
Let
Solutions of differential equation (1) for the Prisoner’s Dilemma game parameterised as [ 4, 3, 1, 0 | 2 |
The use of expected motion (or mean-field) approximations to understand simulation models and to design interesting experiments has already proven to be very useful in the literature (e.g. Huet et al., 2007; Galán & Izquierdo, 2005; Edwards et al., 2003; Castellano et al., 2000). Note, however, that such approaches are approximations whose validity may be constrained to specific conditions: as we can see in Figure 3, simulation runs and trajectories will not coincide in general. Later in this chapter we show that trajectories and SCEs are especially relevant for the transient dynamics of the system, particularly with small learning rates, but, on the other hand, the mean-field approximation can be misleading when studying the asymptotic behaviour of the model.
\n\t\tThe specification of the model is such that probabilities cannot reach the extreme values of 0 or 1 starting from any other intermediate value. Therefore if we find a simulation run that has actually ended up in an SRE starting from any other state, we know for sure that such simulation run did not follow the specifications of the model (e.g. perhaps because of floating-point errors). For a detailed analysis of the effects of floating point errors in computer simulations, with applications to this model in particular, see Izquierdo and Polhill (2006), Polhill and Izquierdo (2005), Polhill et al. (2006), Polhill et al. (2005).
\n\t\t\tExpected motion of the system in a Prisoner’s Dilemma game parameterised as [ 4, 3, 1, 0 | 2 | 0.5 ]2, with a sample simulation run.
\n\t\t\t\tFigure 5 shows that the expected movement from any state is towards the SCE, except for the only SRE, which is an absorbing state. In particular, near the SRE, where both probabilities are high but different from 1, the distribution of possible movements is very peculiar: there is a very high chance that both agents will cooperate and consequently move a small distance towards the SRE, but there is also a positive chance, tiny as it may be, that one of the agents will defect, causing both agents to jump away from the SRE towards the SCE. The improbable, yet possible, leap away from the SRE is of such magnitude that the resulting expected movement is biased towards the SCE despite the unlikelihood of such an event actually occurring. The dynamics of the system can be further explored analysing the most likely movement from any given state, which is represented in Figure 6.
\n\t\t\tFigure showing the most likely movements at some states of the system in a Prisoner’s Dilemma game parameterised as [ 4, 3, 1, 0 | 2 | 0.5 ]2, with a sample simulation run. The background is coloured using the norm of the most likely movement.
\n\t\t\t\tFigure 6 differs significantly from Figure 5; it shows that the most likely movement in the upper-right quadrant of the state space is towards the SRE. Thus, the walk towards the SRE is characterised by a fascinating puzzle: on the one hand, the most likely movement leads the system towards the SRE, which is even more likely to be approached the closer we get to it; on the other hand, the SRE cannot be reached in any finite number of steps and the expected movement as defined above is to walk away from it (see figure 5).
\n\t\t\tIt is also interesting to note in this game that, starting from any mixed (interior) state, both players have a positive probability of selecting action D in any future time-step, but there is also a positive probability that both players will engage in an infinite chain of the mutually satisfactory event CC forever, i.e., that neither player will ever take action D from then onwards (see Izquierdo et al., in press).
\n\t\t\tThe probability of starting an infinite chain of CC events depends largely on the value of the learning rate
Probability of starting an infinite chain of the Mutually Satisfactory (MS) outcome CC in a Prisoner’s Dilemma game parameterised as [ 4, 3, 1, 0 | 2 |
In summary, assuming that aspirations are different from payoffs (see Izquierdo et al., 2007), a BM process that starts in an initial state different from an SRE will never reach an SRE in finite time, and there is always a positive probability that the process leaves the proximity of an SRE. However, if there is some SRE, there is also a positive probability that the system will approach it indefinitely (i.e. forever) through an infinite chain of the mutually satisfactory outcome associated to the SRE.
\n\t\tThis section illustrates the dynamics of the BM model for different learning rates. Most of the theoretical results that we apply and summarise in this section are valid for any 2×2 game and can be found in Izquierdo et al. (2007). The analysis is presented here in a somewhat qualitative fashion for the sake of clarity and comprehensibility, and illustrates the behaviour of the BM model using the Prisoner’s Dilemma shown in figure 1.
\n\t\t\tIn the general case, the dynamics of the BM model may exhibit three different regimes: medium run, long run, and ultralong run. The terminology used here is borrowed from Binmore & Samuelson (1993) and Binmore et al. (1995), who reserve the term short run for the initial conditions.
\n\t\t\t(Binmore et al., 1995, p. 10)
\n\t\t\tBinmore et al.’s terminology is particularly useful for our analysis because it is often the case in the BM model that the “
If players’ aspirations are below their respective Maximin is the largest possible payoff players can guarantee themselves in a single-stage game using pure strategies.
If players’ aspirations are above their respective
if there is any SRE then the BM system converges to an SRE with probability 1. If the initial state is completely mixed, then every SRE can be asymptotically reached with positive probability.
If there are no SREs then the process is ergodic, so the states of the system present an asymptotic distribution which is independent of the initial conditions.
In the context of the Prisoner’s dilemma game described above, this implies that if players’ aspirations are above the payoff they receive when they both defect (
As mentioned above, when learning takes place by large steps, the system quickly reaches its ultralong-run behaviour. To explain why this is the case we distinguish between two possible classes of systems:
\n\t\t\t\tIn systems where there is at least one SRE, the asymptotic behaviour is quickly approached because SREs are powerful attractors (e.g. see figures 5 and 6). The reason for this is that, if an SRE exists, the chances of a mutually satisfactory outcome not occurring for a long time are low, since players update their strategies to a large extent to avoid unsatisfactory outcomes. Whenever a mutually satisfactory outcome occurs, players update their strategy so the chances of repeating such a mutually satisfactory outcome increase. Since learning rates are high, the movement towards the SRE associated with such a mutually satisfactory outcome takes place by large steps, so only a few coordinated moves are sufficient to approach the SRE so much that escape from its neighbourhood becomes very unlikely. In other words, with fast learning the system quickly approaches an SRE, and is likely to keep approaching that SRE forever (this is the system’s ultralong-run behaviour). As an example, consider figure 7 again: starting from any initial probability to cooperate
In the absence of SREs, the fact that any outcome is unsatisfactory for at least one of the players Recall that each player’s aspiration level is assumed to be different from every payoff the player may receive.
The behaviour of the BM process with low learning rates is characterised by the following features (Izquierdo et al., 2007; Proposition 1):
\n\t\t\t\tFor low enough learning rates, the BM process with initial state
For low enough learning rates
If trajectories get close to an SCE (as
Eventually the system will approach its asymptotic behaviour, which –as explained above– is best characterised by the SREs of the system.
\n\t\t\t\tWhen learning takes place by small steps the transient regimes (i.e. the medium and the long run) can be clearly observed, and these transient dynamics can be substantially different from the ultralong-run behaviour of the system. For sufficiently small learning rates and number of iterations
Excluded here is the trivial case where the initial state is an SRE.
\n\t\t\t\tThree sample runs of a system parameterised as [ 4, 3, 1, 0 | 2 |
Remember, however, that the system will eventually approach its asymptotic behaviour, which in the systems shown in figures 2, 3, 4, 5, 6, 7 and 8 is certain mutual cooperation. Having said that, as Binmore et al., (1995) point out, approaching the asymptotic behaviour may require an extraordinarily long time, much longer than is often meant by long run, hence the term ultralong run.
\n\t\t\t\tTo illustrate how learning rates affect the speed of convergence to asymptotic behaviour, consider once again the Prisoner’s Dilemma game parameterised as [ 4, 3, 1, 0 | 2 |
For
Histograms representing the probability of cooperating for one player (both players’ probabilities are identical) after
We exclude here the meaningless case where the payoffs for some player are all the same and equal to her aspiration (
The noisy process has no absorbing states (i.e. SREs) except in the trivial case where both players find one of their actions always satisfactory and the other action always unsatisfactory – thus, for example, in the Prisoner’s Dilemma the inclusion of noise precludes the system from convergence to a single state. However, even though noisy processes have no SREs in general, the SREs of the associated unperturbed process (SREUPs, which correspond to mutually satisfactory outcomes) do still act as attractors whose attractive power depends on the magnitude of the noise:
Histograms representing the propensity to cooperate for one player (both players’ propensities are identical) after 1,000,000 iterations (when the distribution is stable) for different levels of noise (ε\n\t\t\t\t\t\t\t
\n\t\t\t\tFigures 11 and 12, which correspond to a Prisoner’s Dilemma game parameterised as [ 4, 3, 1, 0 | 2 |
The systems represented on the left-hand side of figure 11, corresponding to a learning rate
Representative time series of player 1’s propensity to cooperate over time for the Prisoner’s Dilemma game parameterised as [ 4, 3, 1, 0 | 2 |0.5 ]2 (left) and [4, 3, 1, 0 | 2 |0.25 ]2 (right), with initial conditions [
\n\t\t\t\tFigure 12 shows that a greater level of noise implies higher destabilisation of the SREUP. This is so because, even in the proximity of the SREUP, the long chains of reinforced CC events needed to stabilise the SREUP become highly unlikely when there are high levels of noise, and unilateral defections (whose probability increases with noise in the proximity of the SREUP) break the stability of the SREUP.
\n\t\t\tEvolution of the average probability / propensity to cooperate of one of the players in a Prisoner’s Dilemma game parameterised as [ 4, 3, 1, 0 | 2 | 0. 5 ]2 with initial state [ 0.5, 0.5 ], for different levels of noise (ε\n\t\t\t\t\t\t\t
Importantly, not all the SREs of the unperturbed process are equally robust to noise. Consider, for instance, the system [ 4, 3, 1, 0 | 0.5 | 0. 5 ]2, which has two SRES: [ 1, 1 ] and [ 0, 0 ]. Using the results outlined in section 7 we know that the set formed by the two SREs is asymptotically reached with probability 1; the probability of the process converging to one particular SRE depends on the initial state; and if the initial state is completely mixed, then the process may converge to either SRE. Simulations of this process show that, almost in every case, the system quickly approaches one of the SREs and then remains in its close vicinity. Looking at the line labelled “ε = 0” in figure 13 we can see that this system with initial state [ 0.9, 0.9 ] has a probability of converging to its SRE at [ 1, 1 ] approximately equal to 0.7, and a probability of converging to its SRE at [ 0, 0 ] approximately equal to 0.3.
\n\t\t\t\tHowever, the inclusion of (even tiny levels of) noise may alter the dynamics of the system dramatically. In general, for low enough levels of “trembling hands” noise we find an ultralong-run (invariant) distribution concentrated on neighbourhoods of SREUPs. The lower the noise, the higher the concentration around SREUPs. If there are several SREUPs, the invariant distribution may concentrate on some of these SREUPs much more than on others. In the limit as the noise goes to zero, it is often the case that only some of the SREUPs remain points of concentration. These are called stochastically stable equilibria (Foster & Young, 1990; Young, 1993; Ellison, 2000). As an example, consider the simulation results shown in figure 13, which clearly suggest that the SRE at [ 0, 0 ] is the only stochastically stable equilibrium even though the unperturbed process converges to the other SRE more frequently with initial conditions [ 0.9, 0.9 ]. Note that whether an equilibrium is stochastically stable or not is independent on the initial conditions.
\n\t\t\t\tEvolution of the average probability / propensity to cooperate of one of the players in a Prisoner’s Dilemma game parameterised as [ 4, 3, 1, 0 | 0.5 | 0. 5 ]2 with initial state [ 0.9, 0.9 ], for different levels of noise (ε\n\t\t\t\t\t\t\t\t
Intuitively, note that in the system shown in figure 13, in the proximities of the SRE at [ 1, 1 ], one single (possibly mistaken) defection is enough to lead the system away from it. On the other hand, near the SRE at [ 0, 0 ] one single (possibly mistaken) cooperation will make the system approach this SRE at [ 0, 0 ] even more closely. Only a coordinated mutual cooperation (which is highly unlikely near the SRE at [ 0, 0 ]) will make the system move away from this SRE. This makes the SRE at [ 0, 0 ] much more robust to occasional mistakes made by the players when selecting their strategies than the SRE at [ 1, 1 ], as illustrated in figures 14 and 15.
\n\t\t\t\tOne representative run of the system parameterised as [ 4, 3, 1, 0 | 0.5 | 0. 5 ]2 with initial state [ 0.9, 0.9 ], and noise ε\n\t\t\t\t\t\t\t\t
Time series of player 1’s propensity to cooperate over time for the same simulation run displayed in
This chapter has characterised the behaviour of the Bush-Mosteller (Bush & Mosteller, 1955) aspiration-based reinforcement learning model in 2x2 games. The dynamics of this process depend mainly on three features:
\n\t\t\tThe speed of learning.
\n\t\t\tThe existence of self-reinforcing equilibria (SREs). SREs are states which are particularly relevant for the ultralong-run or asymptotic behaviour of the process.
\n\t\t\tThe existence of self-correcting equilibria (SCEs). SCEs are states which are particularly relevant for the transient behaviour of the process with low learning rates.
\n\t\t\tWith high learning rates, the model approaches its asymptotic behaviour fairly quickly. If there are SREs, such asymptotic dynamics are concentrated on the SREs of the system. With low learning rates, two transient distinct regimes (medium run and long run) can usually be distinguished before the system approaches its asymptotic regime. Such transient dynamics are strongly linked to the solutions of the continuous time limit approximation of the system’s expected motion.
\n\t\t\tThe inclusion of small quantities of noise in the model can change its dynamics quite dramatically. Some states of the system that are asymptotically reached with high probability in the unperturbed model (i.e. some SREs) can effectively lose all their attractiveness when players make occasional mistakes in selecting their actions. A field for further research is the analytical identification of the asymptotic equilibria of the unperturbed process that are robust to small trembles (i.e. the set of stochastically stable equilibria).
\n\t\tWe are grateful to the Spanish Ministry of Education and Science (Projects DPI2004-06590 and DPI2005-05676 –SIGAME-) and the University of Burgos for providing financial support to conduct this piece of research. We are also very grateful to Jörgen W. Weibull for deriving a mathematical result that we used to produce figure 7, and to Alexandre Eudes, Alexis Revue and Vincent Barra, for helping to implement the applet provided at http://www.luis.izquierdo.name/papers/rl-book.
\n\t\tIn recent years, the emphasis of science and technology has shifted more toward environmental benign and sustainable resources and progress. Green Chemistry is paramount concept in chemistry for sustainability, which is the implementation of a set of principles that minimize or get rid of the utilization or generation of hazardous substances in the design, manufacture, and applications of chemical products [1]. Presently, Sonochemistry is a simplistic pathway for a huge variety of syntheses in organic chemistry. Hence, significant features of the ultrasound approach compared with traditional methods are in higher yields, milder conditions, lesser reaction times, improved reaction rates, formation of purer products, easier manipulation and a role in waste minimization and energy protection [2, 3, 4, 5].
Multicomponent reactions [6] leading to facinating heterocyclic scaffolds must appear as Potent tools for delivering the molecular diversity required in combinatorial approaches for the synthesis of bioactive compounds and producing varied chemical libraries of drug-like molecules for biological screening [7, 8]. Chalcones, or 1,3-diphenyl-2-propen-1-ones, are commonly occurring heterocyclic ring systems and are important structural motifs found in many natural products and pharmaceuticals. It is also known as benzalacetophenone and benzylidene acetophenone. Chalcones are one of the most important classes of flavonoids [9, 10]. Further ring closure reactions of Chalcones can be used to obtain various heterocyclic rings viz.; Pyrazoles, Pyrans, Cyanopyridines, isoxazoles and pyrimidines having different hetero-cyclic ring systems and multiple derivatives can be synthesized using chalcones [11, 12, 13, 14, 15].
The increased environmental concerns needed the replacement of present methods with new more sustainable processes which used the ionic liquids in place of organic catalysts and solvents [16, 17, 18, 19, 20, 21, 22, 23, 24, 25]. Ionic Liquids (ILs), as a class of molten salts, are composed entirely of ions and their melting point is around or below 100°C [26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36]. Due to short reaction times, mild reaction conditions, better yields, easy recyclability thermally stable, non-flammable character with negligible vapor pressure, adjustable miscibility with organic substrates and tunable solvating ability ionic liquids (ILs) have attracted the attention of organic chemists [37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49]. Furthermore, unique physiochemical properties that make them potential candidates for many applications in pharmaceuticals, industry and academia [50, 51, 52].
There are several varieties of ionic liquids being studied, out of them a few Simple functionalized ILs have created unparalleled fascination as they display some benefits for certain base-catalyzed processes, like easy recycling and better catalytic performance [53]. The environmentally benign basic ionic liquids are used as reaction media as well as catalysts in the development of multicomponent reactions (MCRs). Among all such basic ionic ILs [DBU][OAc] has shown the desired results. Some of the key benefits that can be highlighted for utilization of this IL as catalyst are, the desired product obtained without any further purification and the recyclability of the catalyst was found to be up to 5 cycles. The investigation of alternatives with the help of ionic liquids to conventional organic solvents is a developing research area due to increased environmental concerns.
Herein, we are especially interested in developing the potential use of efficient, simple methodology for the ring closure reactions of chalcones using [DBU][OAc] as ionic liquids as a solvent and catalyst. Chalcones can be used to obtain various heterocyclic rings through ring closure reactions (Figure 1).
General scheme of ring closure reactions of chalcones.
Melting points were recorded in open glass capillary tube using Gallenkamp melting point apparatus and are uncorrected. Checked by Thin layer chromatography (TLC) was applied to check the purity of synthesized compounds and Spots were visualized by irradiation with UV lights (254 nm) or by staining with iodine vapors. The Fourier-transform infrared (FT-IR) spectra were recorded on SHIMADZU 8400S FT-IR spectrophotometer and wave number is given in cm−1. The 1H NMR spectra and 13C NMR (by broad band proton decoupling technique) were recorded on JEOL AL spectrometer in CDCl3/DMSO-d6 solvents at 400 and 100 MHz and chemical shift were measured in δ ppm relative to TMS as an internal standard. The Mass (HRMS) spectra were recorded on JEOL SX 102/DA-600 using Argon/Xenon gas. The elemental analysis (C, H and N) were performed using vario-III analyzer at CDRI Lucknow.
According to the reported literature [DBUH][OAc] ILs [54] and [DBUH][Cl] ILs [55] were synthesized by the reaction of 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine (DBU) and acetic acid or hydrochloric acid, respectively.
Chalcones were synthesized according to the reported procedure with minor modification (Figure 2), the synthesized products were characterized by 1H NMR, and physical data and compared with those reported in literature [54].
General procedure of synthesis of chalcones (3a-c).
Chalcone derivative (1 mmol) and methylhydrazine (1 mmol) were ultrasonicated catalyzed by [DBUH][OAc] (5 ml) at 50°C for about 4 h (Figure 3). The crude product was refrigerated overnight. The precipitate formed was filtered off and crystallized from ethanol yielding yellow crystals of the product (4a).
Model reaction for preparation of pyrazole derivative (4a).
1H NMR (400 MHz, DMSO-d6) δ 8.81, 7.94, 7.59, 7.47, 7.44, 7.38, 3.96; 13C NMR (100.15 MHz, DMSO-d6) δ 145.51, 133.32, 131.99, 130.37, 129.66, 128.69, 128.34, 126.78, 125.67, 123.12, 122.13, 40.57; HRMS;
Chalcone derivative (1 mmol) mixed with
Model reaction for preparation of pyran derivative (5a).
1H NMR (400 MHz, DMSO-d6) δ 7.45, 7.32, 7.28, 7.25, 7.01, 5.27, 3.60, 2.28, 2.21, 2.12, 2.05; 13C NMR (100.15 MHz, DMSO-d6) δ 195.02, 164.92, 142.45, 138.87, 131.92, 129.14, 128.97, 128.27, 128.12, 122.84, 107.13, 76.87, 35.62, 35.14, 27.61, 16.76; HRMS;
A mixture of chalcone derivative (2 mmol) with malononitrile (2 mmol) in 5 mL of [DBUH][OAc] was ultrasonicated at atmospheric pressure at 65°C for 3 h (Figure 5). After completion of the reaction, the mixture was cooled to room temperature and the organic layer was concentrated. The pure product was obtained by column chromatography (n-hexane:ethyl acetate = 80:20) to afford the preferred product (6a).
Model reaction for preparation of cyanopyridine derivative (6a).
1H NMR (400 MHz, DMSO-d6) δ 9.21, 8.40, 7.95, 7.62, 7.51, 7.44, 7.46; 13C NMR (100.15 MHz, DMSO-d6) δ 160.21, 152.79, 151.01, 138.51, 138.45, 131.34, 130.03, 129.67, 128.99, 127.91, 121.91, 120.71, 117.22, 110.19; HRMS;
Chalcone derivative (1 mmol) was ultrasonicated with hydroxylamine hydrochloride (1 mmol) in catalytic influence of [DBUH][OAc] ILs (5 mL) at 70°C for 1 h (Figure 6). The formation of product was monitored by TLC. Isoxazole derivative was obtained by keeping the reaction mixture on ice bath, then the desired product was isolated, washed with water, and dried (7a).
Model reaction for preparation of isoxazole derivative (7a).
1H NMR (400 MHz, DMSO-d6) δ 8.66, 7.69, 7.57, 7.50, 7.41, 7.32; 13C NMR (100.15 MHz, DMSO-d6) δ 170.26, 154.95, 131.82, 130.67, 128.61, 128.30, 128.07, 127.55, 126.73, 125.41, 116.74; HRMS;
To the mixture of chalcone derivative (1 mmol), guanidine hydrochloride (2 mmol) was added with [DBUH][OAc] ILs was heated under ultrasonication for 2 h at 55°C. The completion of the reaction was checked by TLC (Figure 7). The reaction mixture poured into ice water and formed product was filtered and recrystallized from ethanol (8a).
Model reaction for preparation of pyrimidine derivative (8a).
1H NMR (400 MHz, DMSO) δ 7.77, 7.64, 7.47, 7.41, 7.15, 2.29; 13C NMR (100.15 MHz, DMSO-d6) δ 160.02, 158.70, 138.09, 136.17, 132.01, 131.05, 130.28, 129.20, 128.35, 125.47, 112.89; HRMS;
General representation of preparation of chalcone derivatives (4-8a-c).
In this chapter, the ring closure reaction of chalcone derivatives in the presence of basic ionic liquid [DBUH]OAc to afford the several derivatives like pyrazoles, pyrans, pyrimidines, isoxazoles, and cyanopyridines. Different catalytic systems were used to optimize the reaction conditions on the set of model reactions.
The reaction conditions were optimized on the respective model reactions, further these optimized reaction conditions were used to produce corresponding derivatives of chalcones (Table 1).
% yield of desired products (4-8a,b,c).
We have carried out the synthesis of a number of chalcone derivatives (4-8a,b,c) under different reaction conditions. The optimized conditions for all the ring closure reactions of chalcones involved use of [DBUH]OAc ILs as catalyst under sonication for appropriate time at adequate temperature (Table 2, Entry 6).
S. No. | Catalyst / Solvent | Reaction Condition | Pyrazole Derivative (4a) | Pyran Derivative (5a) | Cyanopyridine Derivative (6a) | Isoxazole Derivative (7a) | Pyrimidine Derivative (8a) | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Temp (°C) | % Yield | Temp (°C) | % Yield | Temp (°C) | % Yield | Temp (°C) | % Yield | Temp (°C) | % Yield | |||
1. | No catalyst / DCM | Reflux | 120 | <5 | 120 | <5 | 120 | <5 | 120 | <5 | 120 | <5 |
2. | NaOH / DCM | Sonication | 100 | >15 | 100 | >15 | 100 | >15 | 100 | >15 | 100 | >15 |
3. | [MIM]BF4 IL | Sonication | 100 | 40 | 100 | 35 | 100 | 42 | 100 | 45 | 100 | 38 |
4. | [MIM]OH IL | Sonication | 90 | 48 | 90 | 42 | 90 | 51 | 90 | 55 | 90 | 44 |
5. | [DBUH]Cl IL | Sonication | 90 | 62 | 90 | 65 | 90 | 68 | 90 | 62 | 90 | 60 |
6. | [DBUH]OAc IL | Sonication | 50 | 97 | 60 | 95 | 65 | 93 | 70 | 94 | 55 | 96 |
Optimization of reaction conditions.
The catalytic reusability of ILs was observed during optimized reaction conditions. The ILs were easily recovered as filtration after the completion of reaction. The recovered ILs were used four times without remarkable loss in activity but after that there is sudden decrease (Figure 9) in yield of products.
Reusability and recyclability of [DBUH]OAc ILs.
In Summary, we developed a simple and efficient catalytic system that can effectively promote the conversion of chalcones into different derivatives viz.; Pyrazoles, Pyrans, Cyanopyridines, isoxazoles and pyrimidines
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In the current study, removal of heavy metal ions from water/wastewater and the use of response surface methodology (RSM) for experimental optimization were examined thoroughly. The objective of this work was to summarize the removal of heavy metal ions from water/wastewater using various chemical techniques and to emphasize the superiority of RSM in these studies.",book:{id:"9407",slug:"biochemical-toxicology-heavy-metals-and-nanomaterials",title:"Biochemical Toxicology",fullTitle:"Biochemical Toxicology - Heavy Metals and Nanomaterials"},signatures:"Muharrem Ince and Olcay Kaplan Ince",authors:[{id:"258431",title:"Prof.",name:"Muharrem",middleName:null,surname:"Ince",slug:"muharrem-ince",fullName:"Muharrem Ince"},{id:"266549",title:"Dr.",name:"Olcay",middleName:null,surname:"Kaplan Ince",slug:"olcay-kaplan-ince",fullName:"Olcay Kaplan Ince"}]},{id:"67269",doi:"10.5772/intechopen.86213",title:"Polycyclic Aromatic Hydrocarbons (PAHs) and Their Influence to Some Aquatic Species",slug:"polycyclic-aromatic-hydrocarbons-pahs-and-their-influence-to-some-aquatic-species",totalDownloads:1256,totalCrossrefCites:7,totalDimensionsCites:17,abstract:"Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants generated primarily during the incomplete combustion of organic materials (e.g., coal, oil, petrol, and wood). Many PAHs have toxic, mutagenic, and/or carcinogenic functions. PAHs are highly lipid soluble which lead to a fast absorption by the gastrointestinal tract of marine mammals. They are immediately distributed in a vast variety of tissues with a notable tendency for localization in body fat. Metabolism of PAHs is obtained via the cytochrome P450-mediated mixed function oxidase system with oxidation or hydroxylation as the first step. PAHs are environmental contaminants that pose significant risk to health of fish. The effect of PAHs on fish is a topic of rising attention in a lot of countries. Different studies using the bile metabolites separated by high-performance liquid chromatography with fluorescence detection were presented. The aim is to compare the levels of PAH metabolites in fish from different areas and fish species. The major metabolite present in all fish was 1-hydroxypyrene. The data confirm the importance of 1-hydroxypyrene as the key PAH metabolite in fish bile and suggest that the European eel is an ideal species for monitoring PAHs.",book:{id:"9407",slug:"biochemical-toxicology-heavy-metals-and-nanomaterials",title:"Biochemical Toxicology",fullTitle:"Biochemical Toxicology - Heavy Metals and Nanomaterials"},signatures:"Ayoub Baali and Ahmed Yahyaoui",authors:[{id:"288629",title:"Ph.D.",name:"Ayoub",middleName:null,surname:"Baali",slug:"ayoub-baali",fullName:"Ayoub Baali"},{id:"293206",title:"Prof.",name:"Ahmed",middleName:null,surname:"Yahyaoui",slug:"ahmed-yahyaoui",fullName:"Ahmed Yahyaoui"}]},{id:"66089",doi:"10.5772/intechopen.85159",title:"Water Resource Pollution by Herbicide Residues",slug:"water-resource-pollution-by-herbicide-residues",totalDownloads:1294,totalCrossrefCites:7,totalDimensionsCites:11,abstract:"Herbicides are frequently used in the chemical control of weeds in various crops in Brazil and worldwide, so they are more frequently detected outside the application areas, contributing to the risk of environmental contamination. The importance of knowledge of the physicochemical properties of the environment and the pesticide used in the agricultural area is in order to understand its effects on terrestrial and aquatic ecosystems and the search for the prevention of future bioaccumulation potentials (bioconcentration and/or biomagnification) of molecules of pesticides in living nontarget organisms, minimizing their negative effects on the environment. The understanding of analytical techniques for measuring the quality of water resources as well as techniques for the remediation of contaminated water is essential to minimize the possible impacts caused by the application of pesticides to the environment.",book:{id:"9407",slug:"biochemical-toxicology-heavy-metals-and-nanomaterials",title:"Biochemical Toxicology",fullTitle:"Biochemical Toxicology - Heavy Metals and Nanomaterials"},signatures:"Kassio Ferreira Mendes, Ana Paula Justiniano Régo, Vanessa Takeshita and Valdemar Luiz Tornisielo",authors:[{id:"162791",title:"Prof.",name:"Valdemar",middleName:null,surname:"Tornisielo",slug:"valdemar-tornisielo",fullName:"Valdemar Tornisielo"},{id:"197720",title:"Ph.D.",name:"Kassio",middleName:null,surname:"Ferreira Mendes",slug:"kassio-ferreira-mendes",fullName:"Kassio Ferreira Mendes"},{id:"258779",title:"Dr.",name:"Ana Paula",middleName:null,surname:"Justiniano Régo",slug:"ana-paula-justiniano-rego",fullName:"Ana Paula Justiniano Régo"},{id:"277330",title:"MSc.",name:"Vanessa",middleName:null,surname:"Takeshita",slug:"vanessa-takeshita",fullName:"Vanessa Takeshita"}]},{id:"70500",doi:"10.5772/intechopen.89601",title:"Challenges for Assessing Toxicity of Nanomaterials",slug:"challenges-for-assessing-toxicity-of-nanomaterials",totalDownloads:1129,totalCrossrefCites:4,totalDimensionsCites:11,abstract:"On the development of nano-world, nanotechnology provides enormous opportunities in daily routine products and further future sustainable innovations. The nanotechnology extends its benefits to various fields such as engineering, medical, biological, environmental, and communication. However, the exponential growth of nanomaterials production would lead to severe complications related to their hazardous effects to the human health and environment. Moreover, negative impact of nanomaterials toxicity on human health is one of the significant issues on exhausting nano-products. The most vulnerable situation is associated with the use of nanomaterials in the biomedical application. The several efforts have been ongoing to study the nanotoxicity and its interaction with the biomolecules. Nevertheless, it is hard to assess and validate the nanotoxicity in a biological system. This chapter aims to study the challenges in determining the toxicity of nanomaterials. The toxicity assessment and hurdles in determining the impact on biological systems are epoch making. In-vitro, in-vivo, and in-silico studies are summarized in this chapter in assessing the toxicity of engineered nanomaterials. The different approaches of toxicity assessment have their difficulties faced by researchers while characterizing nanomaterials in powder form, solution-based, and interacting with biological systems. The assessment tools and characterization techniques play a vital role in overcoming the challenges, while the cytotoxic assays involve nanoparticle shape, morphology, and size consideration.",book:{id:"9407",slug:"biochemical-toxicology-heavy-metals-and-nanomaterials",title:"Biochemical Toxicology",fullTitle:"Biochemical Toxicology - Heavy Metals and Nanomaterials"},signatures:"Akanksha Gupta, Sanjay Kumar and Vinod Kumar",authors:[{id:"309802",title:"Dr.",name:"Vinod",middleName:null,surname:"Kumar",slug:"vinod-kumar",fullName:"Vinod Kumar"},{id:"311316",title:"Dr.",name:"Akanksha",middleName:null,surname:"Gupta",slug:"akanksha-gupta",fullName:"Akanksha Gupta"},{id:"311317",title:"Mr.",name:"Sanjay",middleName:null,surname:"Kumar",slug:"sanjay-kumar",fullName:"Sanjay Kumar"}]},{id:"69211",doi:"10.5772/intechopen.89299",title:"Formaldehyde Advantages and Disadvantages: Usage Areas and Harmful Effects on Human Beings",slug:"formaldehyde-advantages-and-disadvantages-usage-areas-and-harmful-effects-on-human-beings",totalDownloads:1330,totalCrossrefCites:0,totalDimensionsCites:7,abstract:"Formaldehyde, a simple but important member of aldehydes, is highly reactive due to its strong electrophilic properties. It is a colorless, pungent, low molecular weight poisonous gas that can rapidly pass into gaseous phase at room temperature, can burn, and can dissolve very well in water. Formaldehyde, which is found in the natural structure of the organism, is used in many places from industrial areas to household materials and from the production of coatings in dentistry to the determination of cadavers in laboratories. In addition to having such a wide range of uses, it has harmful effects on human health as it can react spontaneously with various cellular elements. In this review, which is based on various sources, detailed information about the definition, properties, usage areas, and harmful effects of formaldehyde will be given.",book:{id:"9407",slug:"biochemical-toxicology-heavy-metals-and-nanomaterials",title:"Biochemical Toxicology",fullTitle:"Biochemical Toxicology - Heavy Metals and Nanomaterials"},signatures:"Nuriye Tuna Subasi",authors:[{id:"279801",title:"Dr.",name:"Nuriye Tuna",middleName:null,surname:"Subaşı",slug:"nuriye-tuna-subasi",fullName:"Nuriye Tuna Subaşı"}]}],mostDownloadedChaptersLast30Days:[{id:"68822",title:"Heavy Metal Removal Techniques Using Response Surface Methodology: Water/Wastewater Treatment",slug:"heavy-metal-removal-techniques-using-response-surface-methodology-water-wastewater-treatment",totalDownloads:2218,totalCrossrefCites:10,totalDimensionsCites:19,abstract:"Advanced water/wastewater treatment techniques including ion exchange separation, filtration separation, and adsorption are essential in the removal of nonbiodegradable toxic wastes from water. 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The boron and nitrogen atoms are linked via strong B-N covalent bonds and form interlocking hexagonal rings. h-BN is used in different areas due to its interesting physical and chemical properties, e.g., in electronics as an insulator and in ceramics, resins, plastics, and paints. Therefore, boron nitride (BN) is also a popular inorganic compound in cosmetic industry (the highest BN concentration up to 25% can be found in eye shadow formulation). It is also widely used in dental cement production (for dental and orthodontic applications). Boron nitride seems to be suitable for biomedical applications; therefore, the cytotoxicity in vitro and in vivo observations of h-BN nanoplates and novel few-layered h-BN-based nanocomposites are still needed. The short-time studies confirm their low cytotoxicity and suggest that BN can be used as a novel drug delivery system; however, medical application needs additional verification in long-term studies.",book:{id:"9407",slug:"biochemical-toxicology-heavy-metals-and-nanomaterials",title:"Biochemical Toxicology",fullTitle:"Biochemical Toxicology - Heavy Metals and Nanomaterials"},signatures:"Magdalena Jedrzejczak-Silicka, Martyna Trukawka, Katarzyna Piotrowska and Ewa Mijowska",authors:[{id:"186478",title:"Dr.",name:"Magdalena",middleName:null,surname:"Jedrzejczak-Silicka",slug:"magdalena-jedrzejczak-silicka",fullName:"Magdalena Jedrzejczak-Silicka"},{id:"231014",title:"Prof.",name:"Ewa",middleName:null,surname:"Mijowska",slug:"ewa-mijowska",fullName:"Ewa Mijowska"},{id:"312078",title:"MSc.",name:"Martyna",middleName:null,surname:"Trukawka",slug:"martyna-trukawka",fullName:"Martyna Trukawka"},{id:"312079",title:"Dr.",name:"Katarzyna",middleName:null,surname:"Piotrowska",slug:"katarzyna-piotrowska",fullName:"Katarzyna Piotrowska"}]},{id:"69211",title:"Formaldehyde Advantages and Disadvantages: Usage Areas and Harmful Effects on Human Beings",slug:"formaldehyde-advantages-and-disadvantages-usage-areas-and-harmful-effects-on-human-beings",totalDownloads:1329,totalCrossrefCites:0,totalDimensionsCites:7,abstract:"Formaldehyde, a simple but important member of aldehydes, is highly reactive due to its strong electrophilic properties. It is a colorless, pungent, low molecular weight poisonous gas that can rapidly pass into gaseous phase at room temperature, can burn, and can dissolve very well in water. Formaldehyde, which is found in the natural structure of the organism, is used in many places from industrial areas to household materials and from the production of coatings in dentistry to the determination of cadavers in laboratories. In addition to having such a wide range of uses, it has harmful effects on human health as it can react spontaneously with various cellular elements. 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The importance of knowledge of the physicochemical properties of the environment and the pesticide used in the agricultural area is in order to understand its effects on terrestrial and aquatic ecosystems and the search for the prevention of future bioaccumulation potentials (bioconcentration and/or biomagnification) of molecules of pesticides in living nontarget organisms, minimizing their negative effects on the environment. 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He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"436430",title:"Associate Prof.",name:"Mesut",middleName:null,surname:"Işık",slug:"mesut-isik",fullName:"Mesut Işık",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/436430/images/19686_n.jpg",biography:null,institutionString:null,institution:{name:"Bilecik University",country:{name:"Turkey"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a scientist and Principal Investigator at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering the lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via artificial intelligence-based analyses of exosomal Raman signatures. Dr. Paul also works on spatial multiplex immunofluorescence-based tissue mapping to understand the immune repertoire in lung cancer. Dr. Paul has published in more than sixty-five peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award and the 2022 AAISCR-R Vijayalaxmi Award for Innovative Cancer Research. He is a senior member of the Institute of Electrical and Electronics Engineers (IEEE) and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null}]}},subseries:{item:{id:"2",type:"subseries",title:"Prosthodontics and Implant Dentistry",keywords:"Osseointegration, Hard Tissue, Peri-implant Soft Tissue, Restorative Materials, Prosthesis Design, Prosthesis, Patient Satisfaction, Rehabilitation",scope:"