Possible optimization techniques.
\r\n\t
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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"67556",title:"A Review of Hybrid Renewable Energy Systems Based on Wind and Solar Energy: Modeling, Design and Optimization",doi:"10.5772/intechopen.85838",slug:"a-review-of-hybrid-renewable-energy-systems-based-on-wind-and-solar-energy-modeling-design-and-optim",body:'\nAccording to recent scientific literacy works [1, 2, 3], about 78–80% of the world commercial energy comes from fossil fuels, such as, petroleum, coal and natural gas. Those high-carbon sources have negative effects in our environments, such as, effects on heath, land, air and rain. In view of that, the attention of most countries around the globe has been shifted to low-carbon energy. Renewable energy is naturally abundant resources, which can be harnessed without compromising future energy needs. Unlike fossil fuels, which depletes as time goes on. Renewable energy sources like wind, solar, biomass, wave and tidal are abundant sources that can produce clean energy. On recent time, series of renewable energy technology improvement has been witnessed, because the cost of generating electrical power is decreasing [4].
\nAlthough, renewable energy is considered as the new technology of generating electricity, the barrier associated with renewable is stochastic and unpredictable weather behavior. Its availability varies depending on the location. That is why, it is necessary to complement renewable with other sources like batteries. Because of this intermittent nature of renewable, single renewable energy source tends to be problematic in terms of energy yield and operational cost. Based on the aforementioned drawbacks, two or more renewable are being combined to form a hybrid renewable energy system (HRES). The main goal of doing this, or to improve electrical power production, to minimize cost, to reduce negative effects associated with burning fossil fuels and to improve the overall system efficiency.
\nIn recent times, the integrated renewable energy system is gaining more attention, because a hybridized system can be efficiently applied to supply high efficiency and reliable electricity to the end-users, unlike a single-renewable source. A HERS can be applied in stand-alone or grid-connected modes. Stand-alone system must have a large storage to handle the load. While in a grid-connected mode, the storage can be small, and the deficient power can be acquired from the grid. It should be noted that, grid-connected mode must have a power electronic controllers for load sharing, voltage, harmonic, and frequency control. Thus HERS operating model is classified into Island mode where the generated electricity is consumed locally and grid connected mode where the renewable energy source is connected to the grid [5].
\nIt is interesting, to note that, among the renewable energy sources, wind power is the fastest growing in terms of global annual and cumulative installed capacity. Wind energy is almost everywhere around the world. But the wind speed strength varies depending on the particular area. Wind energy can be operates during the day and night times, unlike other renewable.
\nSolar is the cleanest and most abundant renewable energy source available on earth (SEIA 2013). Solar energy can be defined as radiant light and heat from the sun and is harnessed by human using technologies.
\nThe amount of energy harnessed from the sun is depending on radiation and scientists define radiation in two different ways which are energy in wave form (electromagnetic wave) or energy in particle form (photons). The electromagnetic radiation emitted from the sun has the wave length interval from 0.1 nm to 104 m. However, 95% of solar energy reach earth with the intervals of 0.3–2.4 μm only [5, 6]. The photons are traveling through space at the speed of 3.0 × 108 m/s and each photon carry different amount of energy measured in electron volts. Photovoltaic (PV) is derived from two words: photo which means light and voltaic or volt means the unit of electric potential. PV or solar cells, also called the semiconductor that converts sunlight to direct current (DC) electricity. PV cell is typically a thin wafer which consists of an ultra-thin layer of phosphorus-doped (N-type) silicon on top of a thicker layer of boron-doped (P-type silicon). The p-n junction is created through the doping and the electrical field is created near the top surface of the cell. When a sunlight which carries photons strike the PV cell, the current is produced because the photons prompt the electrons flow from n- to p-junction. A typical silicon PV cell will produce about 0.5 ~ 0.6 V under open-circuit condition regardless of size. The current produces is proportional to the intensity of sunlight striking the surface as well as the efficiency and size of the cell. The photovoltaic cell normally connected in series or parallel circuit to produce the desired amount of current. PV modules consist of PV circuits sealed in an environmentally protective laminate. PV module is the fundamental building blocks for a PV system. PV panels involve one or more PV module assembled as pre-wired, field-installable unit. Series of PV panels are called a PV array which is ready-installed unit for power generation. The performance of PV modules and array are basically rated according to their maximum power output (w) tested under Standard Test Conditions (STC). Standard Test Conditions are defined as a cell (module) operating temperature of 25°C (77°F) and incident solar irradiance level of 1000 W/m2.
\nBecause of the aforementioned reasons, this chapter focuses on design, modeling, optimization, control and sensitivity analysis carried out on a hybrid system based on wind energy with a PV system.
\nThe terms are technical in nature and there brief explanations will go a long way to concept discussion the hybrid renewable energy power system characteristics, thus, optimization, reliability, grid, micro grid, macro grid, diverse generation, hybrid energy system, and hybrid renewable energy system.
\nThe term optimization is defined as a process, act or methodology of making system design or decision functional or effective as possible according to Hong and Lian [6]. Two practical fundamental methods of optimization exist, thus, the metaheuristics and the simulation-based, will be further discussed in the section of optimization. In another perspective, it is reported that it is finding of an alternative with the highest achievable performance and most cost effective under some constraints through maximizing desired factors and minimizing the undesired ones. However, maximization means an effort to attain desired highest system performance, reliability outcomes regardless of cost and this perception is equally testified by Hong and Lian [6]. However, any practical optimization could be restricted by lack of full data or information, whereas, if some data are available while others are not then linear programming can be employed. Conversely, the optimal sizing of renewable power system components to increase their energy, capacity or performance, thus, providing power, reliability impact is considered optimization according to Kaabeche et al. [7]. Consequently, Power system hybridization is an infrastructural design exploration using optimization tools to configure hybrid renewable energy components to enhance the power reliability enabling zero or minimal loss of power supply probability (LPSP). Probability is the likely hood of getting optimal power supply reliability, and that, notwithstanding all depends on the power supply infrastructure redundancy status. Redundancy of power components can either be fully active or partially actively working with the system structure to allow smooth electric power supply distribution without interruption. Passive means the components are on standby and are only engaged at the point when component failure occurs. Subsequently, system reliability with active redundancy has smoother power supply that does not allow loss of power supply or allows only minimal loss than the passive redundancy reliability component.
\nDependable, consistent, trustworthy, and steadfast are always watch words for reliability term, and relating to energy delivery to consumer electric loads it means consistent qualitative power supply. The Power supply system is actually designed with redundancy and diagnostics in order to achieve power supply optimal reliability. Redundancy takes several concepts of the simple arithmetic, such as, N + 1, N + N, or 2N for maximum reliability such as system automation as expressed [8]. The ‘2N’ redundancy element stands out to provide a better redundancy than the others; it means the two coefficient multiplied by existing components as ‘N’ size. Power supply consistency depends on availability of alternative energy sources and backups such as energy storage subunits as applicable to hybrid renewable energy power supply.
\nThe term hybrid in its self means a mixture of two different components with about similar results for a specific purpose, for example, a hybrid solar-micro hydro renewable energy source (HRES) to supply a rural community with reliable electricity. Conversely, the solar resource is understood to be stochastic by nature and it is the characteristics unlike micro hydro, so they function better when hybridized or designed to work complementing each other. The hybrid resources, improve upon by attaching hybrid energy storages so that the energy converters are supported by energy storage in an effort to attain zero loss of power supply probability (LPSP) [9]. In addition, the preceding hybrid capacity is extended by integrating electronic controller automation in the style of PLC/SCADA. Any consistency in power supply obviously means there should be insignificant loss of power supply probability (LPSP) at any given time in the operation of the system. The probability that a system delivers consistent qualitative output power over long time period is considered to be reliable as interpreted by this author [6]. Hence, a reliable system is characterized by dependable power supply expressed mathematically in terms of mean time before failure (MTBF), and arithmetically expressed as reliability.
\n\n
However, the mean time before failure is the predicted elapse time between operating system inherent failures using a Monte Carlo tool of simulation for reliability optimization and Perturb and Observe for maximum power point tracking for (MPPT) optimization.
\nDependence on the provision of adequate components spare in case of urgency by employing redundancy is a healthy technical strategy attracting extra intervention costs. Plainly, idleness is what redundancy means and though there are two types, the passive and active types synchronized with the system, whereas, the passive types are most times in the standby mode waiting to be called upon for activity as explained by. Thus, the design of hybrid renewable energy resources structure, hybrid energy conditioner, hybrid energy storages and hybrid control platform for automatic energy management.
\nThe physical framework of which electric power is produced using diverse generators to supply the load using electric conductors and cables overhead or underground transmission and distribution networks, usually use assorted transmission and distribution equipment. The Figure 1 represents electric power of three phase grid emanating from the generating station through step up transformer connected to three phase transmission lines and connected to step down transformer that distributes electric power to various consumer loads as explained by Diaf et al. [10]. The grid in Figure 1 is a three phase alternating current network for alternating current (AC) loads, and conversely, a direct current (DC) model are also use for diverse loads as observed by Rao [11] Figure 1. Illustrates multiple grids made available and categorized as micro, and large networks connected to diverse conventional and renewable energy generators.
\nElectric power multiple grids (transmission and distribution).
Micro grid is said to be a network designed to integrate distributed energy resources, control operation, power quality issue, and energy management infrastructure for load demand and power supply stability. It is the smallest facility common among the grid with diverse generators using extra low voltage three phase-four wire supply down to single phase three wire or two wires supply configuration to provide electricity supply to consumers load. Furthermore, micro grid is considered to be a group of distributed resources (DER) and loads forming an electrical network. It has a grid of low-voltage distribution energy resource (DER), energy storage system (ESS) and/or micro sources such as photovoltaic, fuel cell, wind turbine, etc. Micro grid may have controllable energy sources such as biomass, hydro, fossil fuel or uncontrollable energy sources like solar and wind or may be flow-of-the-river that is dependent on daily, monthly and annual rain falls. Controlling solar and wind-micro grid is challenging it involves measuring the parameters such as solar irradiance or Insolation, PV array voltage, PV array current, ambient temperature, wind speed, and AC load pattern for a year evaluation. Conversely, the renewable energy storage loss, energy converter average yield, peak period parameters are used for evaluation of micro grid power performance as reported by Mohammadi et al. [12].
\nA single source of electric power delivery to the consumer, local load is a diverse generation strategy such as conventional fossil fuel generation like oil, coal, etc. or renewable energy method such as solar, wind, hydro, biomass, geothermal, etc. Diesel or gasoline generators that are usually and commonly use in the rural areas are all categorized as small diverse electric generators’ power sources. The diverse generator located by left of the figure and representing either of conventional or renewable energy diverse source according to this author [13]. The integration of diverse energy sources for the operation, control, power management in real time power system make up a micro grid or network as positioned by Ashourian et al. [14]. Obviously, micro grid has distribution structure like the macro grid except that it is a smaller size, in a tiny network, and has a low power capacity. Diverse generation is made into a hybrid design mix whenever the hybrid energy storage is integrated into the micro grid structure to reliably evacuate power to the load.
\nIt will be good to start with hybrid energy system (HES). Hybrid energy system is the engineering design of hybridizing power supply components or pairing them, for example, arranging diverse energy resources to work in parallel (equivalent) is very common in power. So, hybridizing is defined as forming crossbreed of pairs of agent for working together to achieve a purpose. Thus, hybridizing is to manually or automatically synchronize two or more electric power generator resources or components to supply electric power to the grid, therefore forming hybrid energy system. Hybrid energy system is an infrastructural design that integrates diverse or multiple energy converters to energy storage, energy conditioners, energy management system. By and large hybrid renewable energy system (HRES) is an extension of HES that uses mix diverse resources as hybrid or all hybrid renewable energy resources to supply the electric power system.
\nThe concept of the hybrid RE power system is the perception to implement reliability portfolio to avert LPSP that will affect the quality of power supply resulting in dynamic change and transient. Hence, reliability is the dependability of systems or components to be able to function appropriately under stated conditions for a specified period without failure. Furthermore, reliability is said to be a probability of success, expressed as reliability (R) equal to “1” minus (Pf) probability of failure i.e.,
On the other hand, reliability covers several unique modus operandi which provides high quality output, affording utmost availability through redundancy, and advanced problem-solving capabilities of hybrid RE power system as stated by Mat et al. [15]. Thus, HES assume several design types such as multiple fossil fuel energy sources, diesel generator-SPV renewable energy sources or other hybrid renewable energy resources mixture. And the hybrid system reliability can be improved through the integration and optimization of essential components such as energy resources, energy storage and energy management. Hybrid energy renewable systems are economical, less or no fossil fuel consumption for all RER, and have no or less greenhouse gas emission. Solar, hydro and other renewable energy sources are environmentally safe and have adequate power generation potentials. Therefore the integration of these sources with energy storage as hybrid system has economic returns as supported by Mat et al. [15].
\nHybrid renewable energy power system (HREPS) is a cross breed or mixture of matching (parallel) power system infrastructure designed to offer power supply reliability. Hybrid renewable energy power system (HREPS) has enormous designs or models that consists of five common subunits, namely, (i) renewable energy resource (RER) or energy harvester, (ii) electrical system (energy conditioners), and (iii) energy storages system (ESS), however, (iv) a common Bus and (v) electronic logic controller (ECS) is included for system management. Hence, HREPS has several designs of hybridizing by optimal selection of appropriate components that consists of energy harvester, electrical energy conditioner, ESS, common bus and electronic logic controller, however, all hybrid design emphases on hybridizing RER than any of the five components. Thus, adapting redundancy norm on all subunits in order to avoid loss of power supply probability (LPSP) is necessary in order to realize optimal design. The nomenclature hybrid renewable energy power supply (HREPS) design requires the following project proposal subunits to be, the hybrid renewable energy resource (HRER)-hybrid energy storage system (HESS)-hybrid energy conditioner (HEC)-hybrid energy management (HEMS) of four modules hybridized subunits. Each of the subunit is expected to complement its pair to compromise optimal design to be modulated and simulated using simulation-based optimization in order to achieve power supply reliability devoid of loss of power supply probability (LPSP).
\nHybrid renewable energy power system (HREPS) optimization is hereby defined by Giraud et al. [16] as finding the utmost feasible performance or the most cost effective approach under given constraints by maximizing desired factors and minimizing undesired ones. In the case of this design performance was considered priority so, energy reliability is more pleasant than its scarcity (energy shortages). For illustration, gasoline generators were the only electricity source in the remote and rural areas else the community had to live with lanterns. Consequently, maximization of the means to obtain the highest result for electricity provision is better regardless of the cost. Therefore, an act, process or methodology of making a design to function effectively for specific purpose is termed system optimization as from [17]. Two factors are the probable yardstick in determining the hybrid potential of any given site constraints, namely, the optimization and levelized costs of electricity (LOCE).
\nOptimum or best methods to explore the hybrid renewable energy system for power supply reliability are enormous. The RE use has been historically, abundantly everywhere, omnipresent, free cost, and non-polluting characteristics leading to the increase of required storage capacity. A small hybrid system is understood to economical and may not meet the user load demand, whereas the large one can provide reasonable power, but it is expensive. Hence, optimal sizing of RE power system demand mathematical model of the system component characteristics using special techniques to extract maximum power from the models. Also, hybrid system has a complex control system due to the stochastic and multiple power harvesters, for example, the maximum power point (MPPT) technique employed in system SPV makes the system more complex [18]. This hybrid and MPPT approach is termed the optimization of the SPV stochastic power component to meet operational power supply demand.
\nIn addition, optimization of hybrid renewable energy power systems has two techniques, the optimum tools or component based on site available energy resources and the sizing of the components, and use the appropriate control strategy that will [19] automate operation of the integrated hybrid system. Optimum HREPS design, configuration can be conducted using several optimization algorithms such as numerical, probabilistic and heuristic methods under some conditions as reported by these authors [11]. Whereas, feasibility factor is an index called localized cost of energy (LCOE) used to find cost of the average price of electricity produced by the HRES over its life. These variables include initial investment, development, capital, operation and maintenance, and fuel costs put together for costs analysis.
\nHowever, feasibility factors of using optimization are complex, nonlinear, and nonconvex because of the unique mixed constraints. Optimization approach are said to be fundamentally two, namely, the Simulation-based that is tedious, time consuming, prone to human errors and the metaheuristic method using multiple objectives involving cost, performance, supply-demand management, grid limitations, algorithms such as numerical, probabilistic and heuristic methodology as stressed by these authors [20, 10]. Optimization provides economic, efficient, and reliable power supply alternative energy without LPSP. Several of hybrid renewable energy power system optimization concepts were listed in Table 1 in six groups. Their names are the graphical construction, probabilistic approach, deterministic approach, iterative approach, artificial intelligence, and software based (simulation-based) as stated by these authors [15]. However, a read-made HOMER software is a tool used to model hybrid configuration for optimization that emphasize on two factors, minimizing cost and maximizing performance constraints as asserted by Hong and Lian [6].
\nS/N | \nOptimization technique | \nElements | \nRemarks | \n
---|---|---|---|
1 | \nGraphical construction | \nBattery and PV array | \nUse two parameters | \n
2 | \nProbabilistic approach | \nPerformance of hybrid system | \nBased on statistical data collection approach | \n
3 | \nDeterministic approach | \nStand-alone PV with battery bank | \nUse an equation for determining specific values with constant parameters | \n
4 | \nIterative approach: hill climbing, dynamic programming, linear, and multiple objective | \nHybrid-solar-wind system | \nBased on LPSP to find possible combination of solar-wind combination | \n
5 | \nArtificial intelligence: generic algorithm, particle swarm, fuzzy logic, artificial neural network, and hybrid model | \nHybrid solar-wind system with battery | \nBased on evolution technique | \n
6 | \nSoftware based: homer, and developed GUI application software | \nAll of the above | \nInput file with all necessary information is supplied. The software takes care of other things | \n
Possible optimization techniques.
Next, search-based and Monte Carlo simulation (SMCS) is another optimization pattern use for HREPS and energy storage system (ESS) to check power supply reliability. The SMCS allow chronological behavior and reliability of HREPS to be evaluated through of series of simulated experiments for high power loads reported by Ekren and Ekren [21].
\nEach of the optimization techniques is considered unique because it has design elements that are most appropriate for its application in order to get optimal results. Artificial intelligence optimization consists of five subcategories, generic algorithm, particle swarm, fuzzy logic, artificial neural network, and hybrid model by Arabali et al. [22].
\nPerturb and Observe method is a conventional maximum power point tracking (MPPT) approach used in the energy conditioner subunit. It is said to be a global maximum point (GMP) because the combination of Perturb and Observe quickly searches for first local maximum point (LMP) and the particle swarm optimization (PSO) search for the global maximum point. Experimental report shows this method to be good for hybrid power system because it can track GMP with faster convergence time and better dynamic response than using just PSO alone according to Hakimi and Moghaddas-Tafreshi [23]. Hence, optimization has several approaches, some of them are hereby listed in Table 1, according to techniques and RE system elements under study.
\nA hybrid renewable energy system optimization and components sizing has found to be economically and reliably better in meeting all load conditions with minimum investment and operation cost. This was a disclosure of many research using genetic algorithm, particle swarm optimization, simulated annealing, ant colony algorithm and artificial immune system algorithm results as reported by these authors [23]. Figure 2 depicts a graphical representation of optimization showing that it possesses two edges, the energy production and the energy demand control, conversely, the objective function is optimal design reliability inclined toward its constraints. These constraints determine the energy inputs maximize performance and the other hands LOCE minimize costs by Boubekri [4].
\nHybrid optimization, control and RE power production diagram [
Hybridizing diesel with renewable energy to demonstrate the potential of RE to replace diesel generator. HOMER software platform was used to study the load pattern and modeled for HOMER hybrid RE optimization. Hybrid solar-wind-DG were simulated to get four different technology models. The results show PV/hydro/DG has the highest optimization value in comparison to diesel generator only, [6].
\nRenewable energy (RE) and hybrid energy system (HES) are expanding and the current design method is a simulation based optimization and meta-heuristic optimization methods. HES are medium scale application in remote areas and stand-alone, but they are needed for large scale integration to grid. HES are non-linear, non-convex and composed of mixed variables that cannot be solved using traditional optimization methods. In the alternative, two approaches are used for optional HES design. Simulation based optimization and mete-heuristics optimization methods are limited in view of time consuming, rework, and error proneness analyzed by Arabali et al. [22]. From the onset, design of the hybrid power generation system (HPGS) begins with feasibility studies, analyze the potential and effectiveness using computer simulation as observed by Soysal and Soysal [41].
\nA systematic optimization methodology is to derive formulae hybrid RE system (HRES) Optimization by integration of demand response, day-ahead and real-time weather forecasting, and uploading model using a receding horizon optimization strategy is another approach. Practically demonstrated to a single family residential house HRES by Nfah et al. [24]. The demand-response and weather forecast methods are used to optimize the HRES in order to have minimize costs and maximize performance.
\nFurthermore, the state of the arts advanced generators; power electronic logic controller, grid requirements and control are optimized to improve wind power plant characteristics for efficient power delivery and integration according to Khan and Iqbal [25]. Consequently, the power electronic logic controllers, crossbreed SPV, hybrid ESS, and hybrid RER technology are therefore applicable to a solar photovoltaic power system for improved power reliability.
\nHowever, the approaches here consider optimization in terms of power supply reliability, but not only of the costs. Therefore, operating HREPS in the long run is economically preferable as costs are reduced no replacement reinvestment costs, fueling costs, maintenance costs, loss of power supply probability costs, and unquantifiable environmental degradation costs as economic parameters that indicate running diesel generator alone for power supply is bears exorbitant cost variables than operating hybrid REPS energy system.
\nLevelized energy cost (LEC) or (LCOE) is the unit-cost of electricity during the life period of power supply system in net present value (NPV) terms, often taken as alternative electricity average price to break even over generating system lifetime. However, LCOE is a general critical decision to proceed with a project development or not. There are two simulation models of the levelized cost of electricity (LCOE) available, namely, the EGC spread sheet and the system advisor model (SAM). LCOE is mathematically expressed as the life-cycle cost divided by lifetime energy produced interpreted as to break even. The renewable energy systems have higher initial capital costs outlay (ICC), it however amortizes in the long run with free natural fuel, less operation/maintenance costs and environmental friendliness free of GHG impact plus poisonous gases according to Refs. [25, 27]. Finally, localized cost of energy (LCOE) is an index use to cost average price of electricity produced by the HRES over its life initial investment, development, capital, operation and maintenance, and fuel costs as variables.
\nHence, effective ways to cut energy cost are:
Cut down on development cost, capital cost, operation and maintenance cost
Energy production or increase life span of generation infrastructure. A model of wind generator life was improved to last between 20 and 25 years in Denmark, so this applies to other RE infrastructure as observed these authors [19]. However, informed decisions demand trade off in projects selection using pressing priority or objective functions to maximize.
Cut in operation costs includes fossil fuel, and then increase the price and global greenhouse gas emission concern has motivated hybrid renewable energy system standalone applications. Modeling, simulation and multi objective optimization decision tools supporting the leveraged cost of electricity (LCOE), life cycle cost (LCC), greenhouse gas (GHG) emission objective functions use to evaluate power supply reliability, optimization and market price sensitivity. However, it is difficult to justify LCOE and LCC of standalone RE components in rural electrification projects. Conversely, LEC, LCC and GHG fronts are simplified by pairing LCC-LEC and LEC-GHG for decision making according to Khan and Iqbal [25]. HOMER simulation reported that the LCOE of energy of optimized hybrid PV-Wind-diesel-battery is lower than hybrid energy system without renewable energy mix. Consequently, it was concluded that diesel generator supply alone is not feasible as fossil fuel price increases rapidly as reported by Ekren and Ekren [21].
\nSolar, wind and other renewable integration with energy storage as hybrid system has economic returns of LCOE of providing adequate power, environmental friendliness and reliability for all load conditions as supported by Nema et al. [26] Alternatively, three analyses model were put to test costs-benefits of solar PV, thus, short-run, medium-run and the long-run analyses. The short-run considers costs-effectiveness on incremental increases, the medium-run focus on non-incremental change implications in solar capacity, whereas, the long-run dwell on carbon targets of the twenty-first century. Hence, economics depends on grid integration costs, low-carbon technologies and technological advances potential [27].
\nThe common cost-effective criteria in photovoltaic phenomena rely on policy jurisdiction, frame work such as incentives like fit-in-tariff (FIT), tax credits, carbon reduction certificates variables motivates investors. Economically, return on investment (ROI) is always a prominent business yard stick and motivator for an investor. Conversely, feasibility study on solar PV indicated that it has long term high yield rate of return (ROR), see Table 2 give details as reported [28].
\nS/No | \nPV type | \nPayback period range (years) | \nEmission rate (gCO2-eq/KWh) | \nRemarks | \n
---|---|---|---|---|
1 | \nThin film | \n0.75–3.5 | \n10.5–50 | \nEnvironmentally friendly and suitable | \n
2 | \nMono-silicon | \n1.7–2.7 | \n29–45 | \nDitto | \n
3 | \nAdvanced PV system technologies | \n|||
I | \nHigh concentration | \n0.7–2.0 | \nLower than above rate | \nEnvironmentally friendly and suitable | \n
II | \nHetero-junction | \nDitto | \nHigher than above rate | \nDitto | \n
III | \nDye-sensitized | \n– | \n– | \nRate research is ongoing | \n
Feasibility on PV types with payback period and environmental impacts.
Electricity bus is a good conductor in made into a bus-bar for transporting energy from power generator/converter to the grid. Hybrid renewable energy power system (HRES) has two levels of voltage bus the DC and AC produced by the mixture and crossbreed of energy resources.
\nThe two levels AC and DC bus by extension are fundamentally two configurations, namely, the series and the parallel bus arrangements as shown in Figure 3 for the series connection, Figure 4 and Figure 5 for parallel bus as reported by Zhou and Sun [29]. These authors have illustrated the ideology of hybrid methodology can be synchronized to serve the electric load better, meaning mixing energy to improve the power of equivalent RE converter infrastructure to have reliability in power supply delivery.
\nSeries hybrid RE power system with single AC bus for all AC load [
Parallel (hybrid) RE power system with both AC and DC bus plus AC and DC loads [
Parallel hybrid RE system with both AC and DC bus for only all AC loads [
The Figures 3, 4, 5 are in one line/block schematic representing three phase system for hybrid RE resources to produce output voltage waveform shown in Figure 6. However, hybrid RE can be also be designed to supply single phase system for smaller single phase load demand and its output voltage wave is single implied.
\nHybrid RE three phase output voltage waveforms [
Hybridizing is a common strategy for improving the sizing of renewable resource (RER) energy resources; it is also known as crossbreeding in the SPV. The optimum scale of renewable energy resource to harvest energy reliably depends on the optimal design of conversion model. Energy converters are RER and come with assorted characteristics, sizes, and brands guide in the design and the implementation of projects. The RER characteristics of solar photovoltaic and micro hydro are the main focal area to be considered for discussion and analysis in this study. Henceforward, RER as the name implies, are replenish able resource that naturally are regenerated in accordance with the climatic condition and topography of the locality of solar, hydro, and so on as established by Mohammadi et al. [12]. The common among the renewable energy resources are solar and hydro considering their technical and economic benefits as considered by Daut et al. [13]. Solar photovoltaic and micro hydro resources have several statistical variations in nature and are therefore are dependent on the peculiarity of specific geographical location’s weather.
\nFrom the deep literature survey conducted, a lot of studies are being done with divergent ideas and necessities on the possibility of integrating wind and PV system. The studies can be classified into, modeling, design, optimization, control and techno-economic strategies. On the other hand, some researchers proposed a stand-alone hybrid system, while others applied wind and PV system in grid connected mode.
\nA lot of modeling and design of the PV and Wind have been developed using different approaches. The design can be categorized into two, it can be a grid or stand-alone. A grid PV-Wind system proposed by Harini et al. [31] used Wind generator, wind side converter, DC-DC converter, and grid interface inverter. The MPPT is used to optimize the DC voltage coming from the solar panels. The design was implemented in Matlab environment using Simulink. The schematic diagram of the overall system is shown in Figure 7.
\nSchematic diagram of a grid PV-Wind system.
PV-Wind hybrid system was used to generate electricity in Iraq; the planned system was simulated using MATLAB solver, where the input variables for the solver were the meteorological data for the selected areas and the sizes of PV and wind turbines. Outcomes revealed that it is achievable in Iraq to implement the solar and wind energy to come up with enough power for some communities in the desert or rural area. Additionally, it is feasible to use such a system as a black start source of power in the course of total shutdown time. Final results also showed that the desired place for this system is in Basrah for both solar and wind energy [32].
\nA Wind-PV-diesel hybrid power system is developed using HOMER software for a small town in Saudi Arabia which happens to be at the moment powered by a diesel power plant comprising of eight diesel generating sets of 1120 kW each, The annual contributions of wind, solar PV and the diesel generating sets were 4713.7, 1653.5, and 11,542.6 MWh, respectively [33]. Performance of hybrid PV-Wind for hydrogen generation was studied in Sopian et al. [34]. The system consists of photovoltaic array, wind turbine, PEM electrolyser, battery bank, hydrogen storage tank, and an automatic control system for battery charging and discharging conditions. The system generated 130–140 ml/min of hydrogen, for an average global solar radiation and wind speed varying from 200 to 800 W/m2 and 2.0 to 5.0 m/s respectively. While authors [35] have design small-scale electric grid based on hybrid PV-Wind, the model is shown in Figure 8. Presented results shown that the coupling of subunits reduces annual grid power transfers by more than 10% and increases the renewable power contribution to the demand by almost 7% [35]. To increase efficiency of PV-Wind hybrid system. Multi wind turbines and PV systems was successfully model in Mikati et al. [35]. The simulation outcomes revealed that the power end result of the wind turbines in multi-turbine wind-solar hybrid system improves by 18.69, 31.24 and 53.79%, when used in Shenyang, Shanghai and Guangzhou, respectively, in comparison with the reference system [35]. In the work of [36] as shown in Figure 9, a special hybrid PV and Wind was used to power an UV (ultraviolet) water purification system. A 100-W solar-PV system that has a 500-W wind turbine lead in pumping and filtering adequate water in order to meet the safe and clean water demands of 4000 people (16,000 l/day) at an approximated equipment expense of $4630.
\nSimulation models of the two hybrid systems.
Schematic of UV water filtration system.
One work used [37] a new converter technology to implement a hybrid PV-Wind System using Matlab. The topology utilizes a combination of Cuk and SEPIC converters. This setting enables the two resources to provide the load independently or at the same time dependent on the availableness of the energy sources. Some design includes control strategy for instance, the work of conducted by Moubayed et al. [38] reported a control of a hybrid solar-wind system with acid battery for storage. Steady-State Functionality of a Grid-Connected Rooftop Hybrid PV-Wind system was designed and tested by Kim et al. [39]. The design considers system consistency, power quality, loss of supply, and the effects of the randomness of the wind and the solar radiation on system. Limited studies are being done on micro generation based on PV-Wind, the best example case is a hybrid system with solar energy and wind energy for micro power production [40]. Residential hybrid PV-Wind was developed in [41]. While a PV-Wind with simple MPPT was implemented, the suggested system is desirable due to its convenience, convenience of control and affordable [42]. Few studies consider power generation to support national grid, example one study conducted in Jordan [43]. The need for additional energy tends to make us search for new energy sources. Authors in [44] designed a domestic solar-wind hybrid energy system as shown in Figure 10.
\nImage of the designed hybrid system.
In more remote rural areas, PV and Wind system are widely used to supply electrical energy to consumers. Different methodologies have been applied in that regards. A methodology for optimal sizing of PV and Wind for stand-alone system is presented in [45]. The study aims at minimizing cost using genetic algorithm. The simulation outcomes validate that hybrid PV/WG systems feature reduced system cost when compared to the situations where either solely WG or exclusively PV sources are being used. The work of [46], considered optimization of PV/Wind based on number of solar panels ad wind turbines for minimal cost reduction. The findings of this study showed that optimum battery capacity, with optimum number of PV modules and wind turbines subject to lowest cost can be attained with high accuracy and reliability. One research conducted [12], used particle swarm optimization (PSO) algorithm for optimal sizing of PV and Wind system, though the study is limited to micro-grid system, however, energy storage was included. In Ref. [47], used discrete chaotic harmony search-based simulated annealing (SA) algorithm for optimum design of PV/wind hybrid system. The suggested method is employed to get the best possible design of a PV/wind hybrid system. Simulation results show the outstanding effectiveness of the SA algorithm. The optimization study conducted [48] focuses on off-grid hybrid PV-Wind using different battery technologies based on genetic algorithm (GA) was successfully implemented.
\nSimulation based optimized design has been proposed for a PV/wind hybrid energy conversion system with battery storage under different load and auxiliary energy conditions was developed [21]. The simulation model of the system is implemented in ARENA 12.0, commercial simulation software, and is optimized using the Opt Quest tool in this software. Consequently, the optimum sizes of PV, wind turbine and battery capacity are attained under various auxiliary energy unit costs and two different loads. The best possible results are verified using loss of load probability (LLP) and autonomy analysis. And the financial commitment costs are examined how they are shared among those four energy sources at the optimum points.
\nSimulated annealing (SA) algorithm for optimizing size of a PV/wind integrated hybrid energy system with battery storage was reported [49]. The suggested technique is a heuristic strategy which utilizes a stochastic gradient search for the global optimization. The objective function is the minimization of the hybrid energy system total price. And the selection parameters are PV size, wind turbine rotor swept area and the battery capacity. The best possible result acquired by the SA algorithm when compared with other study’s result. Therefore, it is actually coming up with that the SA algorithm provides much better result compared to Response Surface Methodology (RSM). The research study is realized for a campus area in Turkey.
\nSizing optimization of off-grid PV-Wind using iterative approach was used in [7]. The proposed model takes into consideration the sub-models of the hybrid system, the Deficiency of Power Supply Probability (DPSP) and the Levelized Unit Electricity Cost (LUEC).
\nIn this perspective, several techno-economic optimization approaches for hybrid systems sizing have been revealed in the literature. Iterative methodology has been applied to optimize the capacity sizes of various stand-alone PV/wind/diesel/battery hybrid system parts for zero load energy shortfall [50]. The high price of renewable energy systems has brought to slow usage in many countries. Hence, Neuro-Fuzzy method was used for techno-economical of PV-Wind system. The optimization method used is Adaptive Neuro-Fuzzy Inference System (ANFIS), which is successfully applied to model the PV and wind sources. Comparison was made with hybrid optimization model for electric renewables (HOMER) and hybrid optimization by genetic algorithms (HOGA) software and the results prove an accuracy of 96% for PV and wind [51]. The optimized system is simulated in PSCAD/EMTDC and the results show that low excess energy is realized. In this work [10], the technical-economic optimization research of a stand-alone hybrid PV/wind system (HPWS) in Corsica Island is introduced. Consequently, the main purpose of the research is to calculate the acceptable dimensions of a stand-alone HPWS that ensure the energy independence of the typical rural consumer with the lowest levelized cost of energy (LCE).
\nIt is acknowledged that solar energy and wind energy are two of the most feasible renewable energy resources on the globe, The work of [8] highly recommend an ideal design model for designing hybrid solar-wind systems making use of battery banks for determining the system optimum options and guaranteeing that the annualized cost of the systems is reduced while fulfilling the customized needed loss of power supply probability (LPSP). The five selection parameters involved in the optimization method are the PV module number, PV module slope angle, wind turbine number, wind turbine installation height and battery capacity. The offered technique is used to design a hybrid system to supply power for a telecommunication relay station along Southeast Coast of China.
\nIn a related design techno-feasibility of hybrid PV-Wind was employed for a household in China, using HOMER simulation software. The design PV-Wind ration is 72:28, based on the detailed feasibility study conducted in the study areas. Another similar design in Indonesia [52] focuses on onshore remote areas. HOMER software is used to perform the techno-economic feasibility of the PV/wind hybrid system. The final results also display that a wind turbine and battery are the most significant elements of the PV/wind hybrid system to fulfill requirement loads at night hours. Considering that both of these components give the best advantages to system costs, it is very important to select their utmost sizes to reduce the costs, but by considering that no loads are unmet. Object oriented programming was applied to optimize hybrid PV-Wind system in a study conducted by Belmili et al. [53]. Detailed mathematical model was developed together with optimal algorithm for sizing and techno-economic analysis to identify the system that could ensure an effective energy supply with a most affordable financial commitment.
\nThis chapter presents detailed work conducted on hybrid system based on PV and Wind. The chapter systematically shows the different methodology used in the design, simulation, optimization and techno-economic aspects of PV-Wind Systems. Some design and application of the hybrid PV-Wind are discussed.
\nHybrid renewable energy power system optimal design includes feasibility studies, model-based design, simulation and integration of several hybrid renewable energy resources, energy conditioner, and hybrid energy storage system and hybrid controller for automation to achieve power supply reliability. A hybrid renewable energy system (HRES) technology for reliable power supply has challenges in the design process. Thus, hybrid energy harvester, energy conditioner, energy storage and controller feasibilities, selection and unit sizing, and system configurations are necessary procedures to be carried out. Hybrid energy system components for power, reliability applications related to hybrid energy systems, power system has been reviewed above. In order to highlight the merits of the optimal design of hybrid energy system with a promising sustainable solution for power supply reliability.
\nThe solar photovoltaic flat plate has of enormous adaptable models with the adequate alternative energy potential that could possibly replace conventional fossil fuel system. Application of the best possible of hybrid SPV plate/PEMFC resources, boost maximum power point tracking, integrated multi-level inverter and the hybrid PEMFC-Na_S battery storage, and micro hydropower system yields reliable electricity supply for rural and remote areas.
\nHybrid renewable energy power system can offer socio-economic return when enough power is available in rural areas as business activities is going to be established as the communities do some corn/wood mills, small scale industrial ventures to engage more youth in entrepreneurship.
\nThe authors would like to acknowledge with gratitude the support of Universiti Malaysia Sarawak (UNIMAS) under Postdoctoral Fellowship PD/16/016. Similar thanks go to Kano University of Science and Technology, (KUST) Wudil under UNIMAS-KUST partnership.
\nThe authors have declared that no conflict of interest with regards to the publication of this chapter.
Antiparasitic chemotherapeutics can be categorized as anthelmintics, ectoparasiticides (insecticides and acaricides), and antiprotozoals. Anthelmintics are those agents used to destroy worms and are used as anticestodal, antinematodal, and antinematodal agents [1].
The use of chemical agents against nematodes traced back to the 1990s and those agents were having less effectiveness. Chemicals used for nematode destruction were arsenic compounds, cupric sulfate, nicotine, Chenopodium oil like alkaloids. These chemical compounds were found less effective and more toxic for livestock. Synthetic drug phenothiazine antinematodal characteristics were first reported in the United States and were used as broad-spectrum medicine for nematode treatment in horses, ruminants, and chickens. Phenothiazine is removed from the therapeutic inventory in many countries [1].
From that time scientists were trying to produce an ideal anthelmintic drug that could be used as broad-spectrum dewormers and result in the use of organophosphorus compounds, imidazoles, and tetrahydro pyrimidines. Thiabendazole (TBZ) was developed in 1961 after two decades, and this drug is having high efficiency and safety and broad-spectrum. It was the first-generation benzimidazole group and used against a wide range of hosts, i.e., goats, poultry, sheep, cattle, pigs, horses, and humans against gastrointestinal nematodes, and it shows ovicidal, larvicidal, and adulticidal activities. After TBZ’s success, it was planned to structurally modify it toward evolving drugs with excellent properties. Levamisole was discovered in 1966 and was marketed with the name of hydrochloride (HCL) salt having broad-spectrum antinematodal activities and immunomodulator effects [2].
Macrocyclic lactone derivatives including ivermectin (IVM) were discovered in 1981 broad-spectrum insecticidal activities. After this in 2009 after 28 years, monepantel was commercially released [3]. Broad-spectrum antinematodal synthetic compounds are divided into four major groups, i.e., macrocyclic lactone derivatives including milbemycins/ivermectin, benzimidazole/pro-benzimidazole group, tetrahydro pyrimidines group including morantel, pyrantel tartrate, and imidazothiazoles group including tetramisole and levamisole [1].
Commonly used chemotherapeutic groups are briefly reviewed in this review.
Compounds of this group are metabolized in the body and activate BZ metabolites. Members of this group are oxfendazole, ricobendazole, albendazole, thiabendazole, mebendazole, triclabendazole, oxibendazole, cambendazole, and other chemicals belonging to pro-benzimidazole, i.e., thiophanate, febantel, and netobimin [1].
Benzimidazole is effective against adult nematodes in ruminants and also has ovicidal and larvicidal activities. Some benzimidazole also exhibits anti-trematode and anticestodal activities. They are used in various hosts such as bovine, canine, equine, ovine, feline, reptiles, caprine, birds, and human species. In the case of humans, thiabendazole, mebendazole, and albendazole are used. They are having low toxicity and in some cases can be drenched 10 times than the calculated standard dose rate [2, 4].
All members of this group are having the same mode of action and disturb the energy metabolism of parasitic nematodes through binding with tubulin protein (alpha and beta molecules). This protein is present in plasma and microtubules and forms heterodimers and constructs blocks in polymeric microtubules [1]. Microtubules formation is a dynamic process affected by tubulin ring polymerization and depolymerization. Microtubules play an important role in cell division, energy metabolism, shape, and transport of substrate and protein assemblage. Benzimidazole group members bundle with β-tubulin, and this complex integrates at the propagating ends of the microtubules and inhibits the assemblage of extra microtubules. This whole process is known as capping [5, 6, 7].
They cause parasite undernourishment (due to failure in glucose uptake, the proliferation of microtubules, and protein secretion), reduction in acetylcholinesterase enzyme secretion, reduction in carbohydrate catabolism through fumarate reductase enzyme. Histological investigation of benzimidazole pharmacodynamics also reports their role in disturbance of microtubule aggregation in nematodes at those concentrations that do not influence mammalian cells (Figure 1) [1, 6, 8].
Illustration of four different mechanisms of action by benzimidazoles against GI parasites.
Imidazothiazoles consist of two drugs, i.e., tetramisole and levamisole HCL (LEV). Levamisole is a Levo isomer and has true antinematodal activity while tetramisole is a mixture of Levo and destroys forms. That is why the calculated dose of levamisole is half that of tetramisole.
Levamisole is mostly used in goats, sheep, swine, and cattle while in the case of horses, it is contraindicated. This drug is having potency against both mature and immature stages. That’s why the calculated dosage of LEV is half that of tetramisole with a safety index of twice.
In sheep, goat, cattle, and swine, LEV is administrated, and in horses, mostly it is contraindicated. In several mature and immature stages of alimentary tract nematodes and lungworms, LEV has shown great potential. Whereas LEV is not anticestodal nor it is anti-trematode. LEV has not shown any ovicidal activity such as BZs. Whereas the remedial index of LEV is relatively lower than that of other antinematodal. LEV has also been found effective against hypobiotic larvae of the sheep parasitic nematode,
The working mode of action of levamisoles has depicted that it works as a cholinergic agonist; it acts as nicotinic acetylcholine receptors on the surface of the nematode muscle cells along with neuromuscular junction. The antinematodal potential of LEV is mostly associated with its ganglion stimulant activity. It induces ganglion-like structure in somatic muscle cells of nematodes. The induction ultimately results in determining muscle contractions that are in line with the depolarizing barricades causing paralysis.
The pharmacodynamics of the compound plays an important role in the paralysis that leads to the elimination of helminths promptly through normal intestinal peristalsis (Figure 2) [1, 2].
Illustration of the mechanism of actions of levamisole and ivermectin against GI parasites.
Macrocyclic lactones have different commercialized products that show insecticidal activity against a broad range of parasitic nematodes and ectoparasites (ticks, mites, lice) that infest domestic animals [9, 10]. Avermectins that include doramectin, ivermectin, abamectin, and eprinomectin are the fermented products of actinomycete
The unequal larvicidal and adulticidal activity of IVM against Gastro-Intestinal Tract (GIT) roundworms and lungworms of ruminantia, porcine, and equine is its main factor of characterization [10, 11]. The control of microfilariae of canine heartworm
IVM along with other ML derivatives such as moxidectin is frequently used against haemonchosis in sheep due to its mode of action [1]. This increases their influence by binding to glutamate and GABA-gated chloride channel receptors in nematode and arthropod nerve cells. The whole process results in the opening of the channel and allows the entry of chloride ions (Cl−). This will lead to the paralysis of the body wall, pharyngeal muscles, and uterine muscles in nematodes [12]. It is stated that the sensitivity of dissimilar chloride channel subunits to MLs and expression location are variable characters, and it can be accounted for the paralytic effect of different concentrations of MLs on the neuromuscular systems. It is also stated that nematode paralysis and body wall muscle paralysis can be proved serious for prompt exclusion, also pharyngeal muscle paralysis is more sensitive [13]. It has also been revealed that MLs cause the flaccid paralysis of the pharynx of nematodes along with moxidectin and IVM as it is more sensitive than somatic musculature, which shows that the target is the nervous system of parasites. If the concentration of MLs drops, then the motility of the parasites can be recuperated. As compared with somatic muscles, the paralysis of the pharyngeal muscles, as well as consequential inhibition of nourishing, can be longer. The reason for the ineffectiveness of ML derivatives against trematode and cestode parasites is that these worms do not have receptors at their glutamate-gated chloride channel.
Resistance development against anthelmintics consists of a certain phase, i.e., during first phase, number of parasites developing resistance against specific anthelmintics is less; there is a gradual increase, and heterozygous parasites develop resistance and lead to the final phase where individuals become resistant against those anthelmintics, and the population becomes homozygous parasites population. It is also observed that parasite resistance against a specific anthelmintic also brings resistance against some other anthelmintics groups [14].
Resistance is a drug tolerance ability of a worm and survives in the recommended doses of anthelmintics that are normally an effective dose [15]. Parasitic resistance was first described in 1957, and firstly studied anthelmintic agents were organophosphates, phenothiazine, rafoxanide, thiabendazole, and macrocyclic lactones [16]. Recently different GIT parasites especially
Common | Very common | Less common |
Common | Common | Less common |
Initially, the development of resistance against nematicidal drugs was reported in the Southern hemisphere, and the most resistant was studied on
Country | Anthelmintic drugs | Reference(s) |
---|---|---|
Argentina | BZs, LEV, IVM | [24] |
Australia | Ops, BZs, LEV, TBZ, OXF, Closantel, Morantel | [19, 20] |
Belgium | BZs | [25] |
Brazil | BZs, LEV, IVM, Closantel | [24] |
France | BZs, LEV | [26] |
Germany | IVM,BZs, Pyrantel tarterate, FEN, Febantel, OXF, LEV, TBZ, ALB, MBZ | [27] |
India | BZs, IVM, FEN, Morantel, Closantel, LEV, Thiophanate, | [28] |
Kenya | BZs, LEV, RAF, FEN, IVM | [29] |
Malaysia | BMZ, LEVS, IVM, Moxidectin, Closantel | [25] |
Netherlands | OXFS, LEVS, BMZ, IVM | [30] |
New Zealand | BMZ, LEVS, IVM | [18, 31] |
Pakistan | OXFS, LEVS, ALB, IVM | [32, 33] |
Paraguay | BMZ, LEVS, IVM | [34] |
South Africa | BMZ, IVM, RAF, Closantel | [35] |
Uruguay | BMZ, LEVS, IVM | [36] |
United State of America | FEN, IVM, Pyrantel pamoate, LEVS, TBZ, | [37, 38] |
Zimbabwe | RAF, BMZ, LEVS, | [39] |
Geographical distribution of anthelmintic resistance developed by helminths in different parts of the world (selected references).
ALB = Albendazole, BMZ = Benzimidazoles, FEN=Fenbendazole, IVM = Ivermectin, LEVs = Levamisole, OXFS=Oxfendazoles, RAF = Rafoxanide, and TBZ = Thiabendazole.
Hence, the growing anthelmintic resistance is threatening livestock production, increasing the toxic level in the environment, and ultimately reducing the food availability for human beings [23, 40]. Therefore, the scientists and parasitologists are performing the duty to raise one’s hope by launching alternatives to overcome the developing resistance such as biological control (phytotherapy) [33].
Control of gastrointestinal nematode parasite (GINP).
Numerous techniques and plans have been utilized to lower the gastrointestinal (GI) nematode parasites of small ruminants across the world. Some of the techniques and methods are appropriate, and a few of them have limitations. Moreover, new methods and new approaches are being evaluated and established. The prime methodologies that have been used routinely to reduce the burden of GI nematodes are reviewed here.
Anthelmintics are those drugs that kill the helminths and are playing a toxic role to the worms and can be achieved by exposing the nematodes to a higher concentration of anthelmintics. This higher concentration is for worms not for the host body cells. This higher concentration inhibits the vital metabolic processes of the worms and kills the worm either by starving it or paralyzing it [23]. Resistance is a reduction in the efficacy of certain anthelmintics against parasites that are susceptible to anthelmintics in normal conditions [41]. Chemotherapeutic application is a very common and primitive method (conventional) to control the GINP around the globe. The agents have been used for both therapy and prophylaxis. Benzimidazole, Ivermectin, and Imidathiazole are three major chemical groups that have been used frequently for decades.
Several reports are published that demonstrate the resistance generation of GI nematodes to these chemicals worldwide [23]. Few studies reported the higher level of resistance produced against the broad-spectrum anthelmintics and also reported the side effects at higher dose levels [41]. A higher level of resistance in
Resistance is a global issue, and some regions are more exposed to it as compared with others, e.g., tropical and subtropical regions are more affected by the resistance of GI nematodes [33]. Soli
Regions where haemonchosis is endemic and anthelmintic treatment is frequently used at the farm level are exhibiting more resistance in
In grazing ruminants, copper is administered along with diet as a feed additive to overcome the deficiency symptoms. The use of copper started in the 1900s, in various forms to minimize the worm load (SCSRPC). The use of copper oxide wire particles (COWPs) was found more successful in reducing nematodes, more precisely
For administration in cattle, COWP boluses (Copasure©) of 12.5 and 25 g are available and for small ruminants, smaller dosages of 0.5–2 g are used [40, 43]. The recommended COWP dosage for cattle of weight above 227 kilograms was 12.5 g [45]. The sensitivity of sheep is higher against copper, and a little higher dosage may lead to toxicity although COWP is released slowly. Risk factors of copper toxicity that should be considered during administration are animal breed, age, health status, and other minerals deficiency such as molybdenum, poultry litter exposure [46]. Investigation on the use of COWP among exotic artiodactyls has been performed at Disney’s Animal Kingdom® Lodge. During the trials, four artiodactyl species included roan antelope, blesbuck, scimitar-horned oryx, and blackbuck. The corollary of their study indicated a marked reduction in EFC (above 90%) on day 7 post-COWP therapy. The animal species variations, liver health status, copper level, interaction level with other minerals, and history of copper supplementation should be considered before the implementation of the COWP GIN control program in exotic animals. Before the use of COWP in an integrated pest management program, the impact of COWP on reproduction, accumulation level, and sensitivity level among species should be investigated [45].
In this perspective, the naturally found pest antagonist organisms are used to control the pest population. Grønvold
The biological control strategies were proposed to reduce the parasite population below the economic threshold and clinical level above that considerable production losses are there. High efficacy of
Sheep feeding supplemented with
Strategies for worm load investigation: FEC, larval developmental assays (LDA), FEC reduction test, and fecal larval culture (FLC) have proved valuable linkage with monitoring and control of worm infection. Mainly FEC is used for monitoring and management of GIN parasites. LDA is used for nematode species identification and to explore the resistance level [57]. FLC helps in identifying worm species, seasonal variation, and enclosure of GIN population. FECRT is the most authentic approach to determine anthelmintic resistance, but it is expensive and labor-intensive [57]. The demands for the exploration of alternative strategies toward helminth control have been augmented due to the lack of new anthelmintics. The applications of plants having condensed tannins, COWP, nematophagous fungi, and other biological approaches in combination with anthelmintics, animal management, control of ecological factors, and GIN level monitoring strategies could be effective to overcome GIN resistance in small ruminants.
Among TST methods FAMACHA chart and McMaster are mainly used way to identify the worm-infected animals and require treatment. The former method is used to diagnose anemic animals by comparing their eye (conjunctiva) color with the chart. The latter method provides a real-time picture of parasite burden via egg counting in fecal material. In the McMaster method, fecal material is suspended in floatation solution and supernatants are taken on a specific glass slide (Mc Master chamber) and observed under a microscope for egg counting. For reducing anthelmintic resistance among GI parasites, selective therapy is highly effective. By using the aforementioned methods, medicinal cost of animals declines because they selectively purchase few anthelmintics and animals are responsive against these drugs. On the other hand, selective therapy is laborious and time-taking, farmers have to perform the FAMACHA check once a month. Routine-wise performance of McMaster is mandatory because sometimes with FAMACHA check animals found healthy while through McMaster they were found with high worm burden, and such animals should be treated because these animals may act as a source for others. The FAMACHA score system is found to be highly effective in the selection of worm-resilient animal breeds [58].
For the control of GI nematodes infections, two most commonly used methods include the use of anthelmintics and pasture management; they are associated with reduction of production losses because of nematodes infections. Two ways of producing safe pastures and reducing the infectivity of pasture include rotational grazing and pasture spelling, this strategy is very [59]. In rotational grazing, it is assumed that significant larval mortality occurs because of break-in grazing. But, unfortunately, the period in between animal rotations makes the best use of available and nutritious forage coincides with the period during that high concentration of L3 becoming available for reinfection. In the United States, a study was conducted at a farm and reported that lambs raised under a rotational grazing system were highly infested with helminths in comparison with others. Most of them were infected with nematodes,
With the provision of a good and high level of nutrition, the productivity of animals can be improved with an increase in the immune response against parasites. With an increase in the level of proteins in the diet, an increase in the resistance and resilience of lamb against
In ethnoveterinary medicine, medicinal plants are used for the prevention and treatment of gastrointestinal parasitism. There is a wide range of medicinal plants or plant extracts that are used to treat almost every kind of livestock disease related to parasites. There are so many studies and available literature on the anthelmintic properties of plants and their extracts, which confirms the antinematodal effects of these plants [33, 42, 64, 65, 66, 67]. In comparison to synthetic drugs the herbal preparations are way cheaper and easily available and thus have been used for a long time in the therapy of livestock diseases of helminth parasites [68].
Many plants and herbs are used as control agents for human and veterinary endoparasites, and the efficacy of each plant depends upon the chemical composition and secondary metabolites composition. The composition of a plant is a variable character depending upon soil properties, climatic conditions, geographical variability, and environmental conditions. Anthelmintic activity of a plant is variable in different areas of the world and depends upon the harvest of the plant, plant parts, which are used as anthelmintics, storage of the plant, and combination of different plant extracts [68]. Choice of extraction solvent is also an important factor that affects the solubility of secondary metabolites of the target plants usually water and methanol are used as extraction solvents. Ethanolic extracts are considered a better choice as they can easily enter the body of the parasite through absorption [69].
To determine the plant properties, two different study types are used. i.e., in vitro and in vivo, and each study type has some merits and demerits. In vitro studies are cost-effective and can study a variety of plants at the same time, allowing the study of specific parasites and their lifecycle stages [70]. While in vivo studies are lengthy processes and can study a single plant at a time. Sometimes the result of the in vivo and in vitro can be different as the outcome of the study depends on the internal factor of the host and plant species, e.g., the digestive system of the host [71].
Till today 25% of modern pharmacopeia use plant-derived drugs and some semisynthetic using plant as prototype compound [72]. Anthelmintic efficacy of plants is derived from different parts, e.g., saponins (can cause teguments degradation and vacuolization), tannins, and polyphenols can form a protein complex in the rumen and increase the protein supply, interfere with energy generation, reduction in gastrointestinal metabolism, and ultimately death of the helminth and alkaloids (effect the transport of sucrose transfer from the stomach to the intestine and helminth glucose support is disturbed causing paralysis) [73].
Tannins are compounds that attach with proteins and other molecules and are used as a biological alternative against chemical anthelmintic; many plants naturally contain condensed tannins. There are two main groups in which tannins are divided: one is hydrolyzable tannins (HTs) and the other one is condensed tannins (CTs). Among the two of these groups, condensed tannins are more abundant and are naturally present in browse, legumes, plants, and forage. The concentration of CT, type of animal consuming CT, the plant itself, and the concentration of CT in the plant are the factors that stimulate the effects of CTs. The high concentration of CT can have negative effects, and the noticeable negative effect is reduced palatability that ultimately causes a reduction in intake and digestion, which exerts a negative impact on productivity [46]. There are several benefits of CT intake that include increased wool growth and growth rate, increased amount of bypass protein, reduced bloating, high milk production, as well as a high rate of ovulation.
The prominent and most important benefit of CTs is their positive impact on the GIN infection. It has been observed that CTs specifically
The nutritional combination of animal feed affects the biodiversity of GIT fauna, which may affect the parasite fitness by altering the intestinal environment in which the parasites propagate [63]. Tannins, flavonol glycosides, sesquiterpene, and secondary metabolites are potential candidates for integrated nematode control at the farms level [63, 74, 75]. The plants having these properties are known as nutraceuticals, which are considered for both the nutritional value and as an anthelmintic. It has been reported that supplementation of bioactive plants to goats played role in the regulation of bionomics of resistant parasitic populations along with enhancing the ability of the goat to withstand negative effects of the pathophysiology of parasitic infections [63]. An increase in post-ruminal protein availability playing role in reducing the parasitic infections in large ruminants has also been reported, which may be attributed to the availability of condensed tannins (CTs) or proanthocyanidins and polymers of flavonoid units [48].
The most effective way of controlling infection is vaccination; therefore, demand for vaccine development against GI parasites rises. In disparity with vaccines of viral and bacterial pathogens, vaccine development against parasites did not gain similar success although parasitologists are working in this regard for the last 30 years. The vaccine has been developed against tapeworm and lungworm sheep and cattle respectively. Studies have been conducted in the identification of various antigens of nematodes as vaccine agents [76]. Gut-associated antigens have been reported as vaccine candidates, namely H-gal-GP and H11 of
Traditional use of chemotherapeutic agents against infection of ectoparasites as well as endoparasites leads to the development of resistance against these therapeutic agents. It converges the scientists for exploring the nontraditional ways of controlling GI parasites; development of a resistant breed of the host through selective breeding, vaccine development, implementation of other control measures (alternate pasture grazing and rotational grazing), and synergistic use of anthelmintics [80].
In vaccines, acquired immunity plays a pivotal role in the protection of the host against pathogens, and it needs to be explored for the development of a vaccine. In the case of parasites, the role of acquired immune response is not fully explored. Therefore, vaccine development against GI parasites for protection remains ineffective [81].
Some fungi of
Gastrointestinal nematode resistance to anthelmintics has been growing day by day, gaining currency to consider it for adopting control measures shortly of the domestic livestock industry. The use of chemical anthelmintics in combination with bioactive plants as nutraceuticals seems to be a potential strategy for parasitic control. Alternate strategies, i.e., use of plants containing condensed tannins, plant-based vaccines, COWP, and biological control through nematode-trapping fungi along with husbandry management may prove helpful in minimizing the mortality and morbidity of parasitic diseases in small ruminants. However, animal breeds selected based on their response to nematodes present in the gastrointestinal tract are an alternate control strategy toward minimizing gastrointestinal problems in goats [43].
Identification of resistant individuals is necessary for the production of parasitic-resistant breeds. Two parameters are mostly reported for the selection of resistant breeds, i.e., FEC, which is an indirect parameter for measurement of the relative level of infection [82]. Hematocrit and PCV are being used for the identification of worm burden, especially in the case of
The researchers cannot divide the magnitude of resistance into discrete genetic units; therefore, the resistance is described in the form of heritability estimates [84]. The phenotype of quantitative traits is regulated by the additive effect of specialized genes [85], which are yet to be identified. The resulting resistance may be attributed to the effect of a combination of many small genes or a group of major genes that are being regulated not only by additive effects but also by the environmental effects [84].
Packed cell volume and fecal egg count are the most useful markers/parameters to estimate the response of host challenge and natural infection with nematodes present in GI in general and specifically
Estimations of phenotypic and genetic correlation explained the amount to which genes affect two different traits and the phenotypic correlation guides the number of relations between two traits. Correlation evaluations are important in the measurement of the appropriateness of indicator traits as indirect criteria in programs related to breeding. Mandonnet
Host live weight is a production trait that has been considered as an important parameter while assessing the genetic resistances of the host toward GI nematode parasites. The heritability estimates of live weight (LWT) varied widely ranging from 0.13 in Australian Angora goats to 0.50 in Texan Angora goats [91]. Likewise, heritability estimates have been reported in South Africa goats breed as 0.29 and 0.35 [92]. It has been shown that resistance to infection by nematode parasites may not necessarily equate to resistance to the effects of the parasite challenge in grazing animals [86]. The association between FEC and productivity varies in magnitude and direction depending on the breed and the environment in which the evaluation was done. The genetic correlations between packed cell volume (PCV) and packed cell volume decline (PCVD) and production (live weight and wool growth) are either negligible or favorable [93].
Several studies around the globe have been conducted to assess the genetic potential of sheep and goats breeds that are resistant to gastrointestinal nematodes in the last three to four decades [82, 83, 87, 93]. The selection of breeds that are resistant to gastrointestinal nematode parasites is assuming the most promising alternate control method of gastrointestinal nematodes. Improved resistance toward nematodes control leads to reduced cost of anthelmintic treatment and diminished production losses associated with worm burden. Australia and New Zealand initiate programs on breeding for resistance and adopt them successfully by utilizing phenotypic markers [94]. Approximately 96% of the world’s goat population is kept by smallholders in developing countries, and genetic improvement programs are rare [95].
Host selection for resistance has based mostly on quantitative measurement of phenotypic traits. These traits have been measured to check the response of the host being evaluated for resistance, which are biochemical, immunological, parasitological, and pathological features [84]. For the development of high-resistant breeds, it is necessary to identify the high-resistant individuals. Criteria for the selection of parasitic resistance are commonly based on two traits, i.e., packed cell volume, which indicates anemia, and fecal egg count, which measures the amount of infection. There is variation in the development of resistance between the animals of different breeds and within the same breeds, which is because of their genetic makeup. The scientists are working to investigate the cause of the development of resistance, and up to some extent they succeeded in finding some reasons while the others are under investigation [84].
According to the best of our knowledge about different factors that are responsible for GI parasitism, it is hard to develop control measures. So, the epidemiology of each parasitic disease is needed to be studied at the regional level to recommend an effective strategy for the control of parasitic diseases, which is not completely dependent on anthelmintic therapy [11]. Keeping in mind the subtropical and tropical areas in which dry seasons are more might be grazing management, rational use of anthelmintics, and use of resistant breeds.
The author wishes to thank all other coauthors for providing guidance and support.
The authors declare that they have no conflict of interest.
This is a brief overview of the main steps involved in publishing with IntechOpen Compacts, Monographs and Edited Books. Once you submit your proposal you will be appointed a Author Service Manager who will be your single point of contact and lead you through all the described steps below.
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\n\n2. SUBMIT YOUR MANUSCRIPT
\n\nAfter approval, you will proceed in submitting your full-length manuscript. 50-130 pages for compacts, 130-500 for Monographs & Edited Books.Your full-length manuscript must follow IntechOpen's Author Guidelines and comply with our publishing rules. Once the manuscript is submitted, but before it is forwarded for peer review, it will be screened for plagiarism.
\n\n3. PEER REVIEW RESULTS
\n\nExternal reviewers will evaluate your manuscript and provide you with their feedback. You may be asked to revise your draft, or parts of your draft, provide additional information and make any other necessary changes according to their comments and suggestions.
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\n\nIf the manuscript is formally accepted after peer review you will receive a formal Notice of Acceptance, and a price quote.
\n\nThe Open Access Publishing Fee of your IntechOpen Compacts, Monograph or Edited Book depends on the volume of the publication and includes: project management, editorial and peer review services, technical editing, language copyediting, cover design and book layout, book promotion and ISBN assignment.
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. 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From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. 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Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. 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The literature source was Web of Science and SSCI, SCI-EXPANDED, A&HCI, CPCI-S, CPCI-SSH, and ESCI indexes. Fifty-two articles were reviewed; however, 14 of them were not been included in the study. As a result, 38 articles were examined. Level of education, field of education, and material types of AR used in education and reported educational advantages of AR have been investigated. All articles are categorized according to target groups, which are early childhood education, primary education, secondary education, high school education, graduate education, and others. AR technology has been mostly carried out in primary and graduate education. “Science education” is the most explored field of education. Mobile applications and marker-based materials on paper have been mostly preferred. The major advantages indicated in the articles are “Learning/Academic Achievement,” “Motivation,” and “Attitude”.",book:{id:"6543",slug:"state-of-the-art-virtual-reality-and-augmented-reality-knowhow",title:"State of the Art Virtual Reality and Augmented Reality Knowhow",fullTitle:"State of the Art Virtual Reality and Augmented Reality Knowhow"},signatures:"Rabia M. Yilmaz",authors:[{id:"225838",title:"Dr.",name:"Rabia",middleName:null,surname:"Yilmaz",slug:"rabia-yilmaz",fullName:"Rabia Yilmaz"}]},{id:"63639",doi:"10.5772/intechopen.81086",title:"Cooperative Learning: The Foundation for Active Learning",slug:"cooperative-learning-the-foundation-for-active-learning",totalDownloads:3427,totalCrossrefCites:17,totalDimensionsCites:24,abstract:"The role of instructors is evolving from the presenter of information to the designer of active learning processes, environments, and experiences that maximize student engagement. The more active a lesson, the more students tend to engage intellectually and emotionally in the learning activities. Cooperative learning is the foundation on which many of the active learning procedures are based. Cooperative learning is the instructional use of small groups so that students work together to maximize their own and each other’s learning. Most of the active learning procedures, such as problem-based learning, team-learning, collaborative learning, and PALS, require that students work cooperatively in small groups to achieve joint learning goals. Cooperative learning is based on two theories: Structure-Process-Outcome theory and Social Interdependence theory. Four types of cooperative learning have been derived: formal cooperative learning, informal cooperative learning, cooperative base groups, and constructive controversy. There is considerable research confirming the effectiveness of cooperative learning. To be cooperative, however, five basic elements must be structured into the situation: positive interdependence, individual accountability, promotive interaction, social skills, and group processing.",book:{id:"6929",slug:"active-learning-beyond-the-future",title:"Active Learning",fullTitle:"Active Learning - Beyond the Future"},signatures:"David W. Johnson and Roger T. Johnson",authors:[{id:"259976",title:"Dr.",name:"David",middleName:null,surname:"Johnson",slug:"david-johnson",fullName:"David Johnson"},{id:"263004",title:"Dr.",name:"Roger",middleName:null,surname:"Johnson",slug:"roger-johnson",fullName:"Roger Johnson"}]},{id:"59468",doi:"10.5772/intechopen.74344",title:"Virtual and Augmented Reality: New Frontiers for Clinical Psychology",slug:"virtual-and-augmented-reality-new-frontiers-for-clinical-psychology",totalDownloads:2339,totalCrossrefCites:13,totalDimensionsCites:21,abstract:"In the last decades, the applied approach for the use of virtual reality (VR) and augmented reality (AR) on clinical and health psychology has grown exponentially. These technologies have been used to treat several mental disorders, for example, phobias, stress-related disorders, depression, eating disorders, and chronic pain. The importance of VR/AR for the mental health field comes from three main concepts: (1) VR/AR as an imaginal technology, people can feel “as if they are” in a reality that does not exist in external world; (2) VR/AR as an embodied technology, the experience to feel user’s body inside the virtual environment; and (3) VR/AR as connectivity technology, the “end of geography’. In this chapter, we explore the opportunities provided by VR/AR as technologies to improve people’s quality of life and to discuss new frontiers for their application in mental health and psychological well-being promotion.",book:{id:"6543",slug:"state-of-the-art-virtual-reality-and-augmented-reality-knowhow",title:"State of the Art Virtual Reality and Augmented Reality Knowhow",fullTitle:"State of the Art Virtual Reality and Augmented Reality Knowhow"},signatures:"Sara Ventura, Rosa M. Baños and Cristina Botella",authors:[{id:"106036",title:"Dr.",name:"Rosa Maria",middleName:null,surname:"Baños",slug:"rosa-maria-banos",fullName:"Rosa Maria Baños"},{id:"227763",title:"Ph.D.",name:"Sara",middleName:null,surname:"Ventura",slug:"sara-ventura",fullName:"Sara Ventura"},{id:"229056",title:"Dr.",name:"Cristina",middleName:null,surname:"Botella",slug:"cristina-botella",fullName:"Cristina Botella"}]},{id:"58060",doi:"10.5772/intechopen.72341",title:"Pedagogy of the Twenty-First Century: Innovative Teaching Methods",slug:"pedagogy-of-the-twenty-first-century-innovative-teaching-methods",totalDownloads:8762,totalCrossrefCites:15,totalDimensionsCites:21,abstract:"In the twenty-first century, significant changes are occurring related to new scientific discoveries, informatization, globalization, the development of astronautics, robotics, and artificial intelligence. This century is called the age of digital technologies and knowledge. How is the school changing in the new century? How does learning theory change? Currently, you can hear a lot of criticism that the classroom has not changed significantly compared to the last century or even like two centuries ago. Do the teachers succeed in modern changes? The purpose of the chapter is to summarize the current changes in didactics for the use of innovative teaching methods and study the understanding of changes by teachers. In this chapter, we consider four areas: the expansion of the subject of pedagogy, environmental approach to teaching, the digital generation and the changes taking place, and innovation in teaching. The theory of education, figuratively speaking, has two levels. At the macro-level, in the “education-society” relationship, decentralization and diversification, internationalization of education, and the introduction of digital technologies occur. At the micro-level in the “teacher-learner” relationship, there is an active mix of traditional and innovative methods, combination of an activity approach with an energy-informational environment approach, cognition with constructivism and connectivism.",book:{id:"5980",slug:"new-pedagogical-challenges-in-the-21st-century-contributions-of-research-in-education",title:"New Pedagogical Challenges in the 21st Century",fullTitle:"New Pedagogical Challenges in the 21st Century - Contributions of Research in Education"},signatures:"Aigerim Mynbayeva, Zukhra Sadvakassova and Bakhytkul\nAkshalova",authors:[{id:"201997",title:"Dr.",name:"Aigerim",middleName:null,surname:"Mynbayeva",slug:"aigerim-mynbayeva",fullName:"Aigerim Mynbayeva"},{id:"209208",title:"Dr.",name:"Zukhra",middleName:null,surname:"Sadvakassova",slug:"zukhra-sadvakassova",fullName:"Zukhra Sadvakassova"},{id:"209210",title:"Dr.",name:"Bakhytkul",middleName:null,surname:"Akshalova",slug:"bakhytkul-akshalova",fullName:"Bakhytkul Akshalova"}]},{id:"64583",doi:"10.5772/intechopen.81714",title:"Evaluating a Course for Teaching Advanced Programming Concepts with Scratch to Preservice Kindergarten Teachers: A Case Study in Greece",slug:"evaluating-a-course-for-teaching-advanced-programming-concepts-with-scratch-to-preservice-kindergart",totalDownloads:1409,totalCrossrefCites:13,totalDimensionsCites:18,abstract:"Coding is a new literacy for the twenty-first century, and as a literacy, coding enables new ways of thinking and new ways of communicating and expressing ideas, as well as new ways of civic participation. A growing number of countries, in Europe and beyond, have established clear policies and frameworks for introducing computational thinking (CT) and computer programming to young children. In this chapter, we discuss a game-based approach to coding education for preservice kindergarten teachers using Scratch. The aim of using Scratch was to excite students’ interest and familiarize them with the basics of programming in an open-ended, project-based, and personally meaningful environment for a semester course in the Department of Preschool Education in the University of Crete. For 13 weeks, students were introduced to the main Scratch concepts and, afterward, were asked to prepare their projects. For the projects, they were required to design their own interactive stories to teach certain concepts about mathematics or physical science to preschool-age students. The results we obtained were more satisfactory than expected and, in some regards, encouraging if one considers the fact that the research participants had no prior experiences with computational thinking.",book:{id:"6936",slug:"early-childhood-education",title:"Early Childhood Education",fullTitle:"Early Childhood Education"},signatures:"Stamatios Papadakis and Michail Kalogiannakis",authors:null}],mostDownloadedChaptersLast30Days:[{id:"58060",title:"Pedagogy of the Twenty-First Century: Innovative Teaching Methods",slug:"pedagogy-of-the-twenty-first-century-innovative-teaching-methods",totalDownloads:8743,totalCrossrefCites:15,totalDimensionsCites:21,abstract:"In the twenty-first century, significant changes are occurring related to new scientific discoveries, informatization, globalization, the development of astronautics, robotics, and artificial intelligence. This century is called the age of digital technologies and knowledge. How is the school changing in the new century? How does learning theory change? Currently, you can hear a lot of criticism that the classroom has not changed significantly compared to the last century or even like two centuries ago. Do the teachers succeed in modern changes? The purpose of the chapter is to summarize the current changes in didactics for the use of innovative teaching methods and study the understanding of changes by teachers. In this chapter, we consider four areas: the expansion of the subject of pedagogy, environmental approach to teaching, the digital generation and the changes taking place, and innovation in teaching. The theory of education, figuratively speaking, has two levels. At the macro-level, in the “education-society” relationship, decentralization and diversification, internationalization of education, and the introduction of digital technologies occur. At the micro-level in the “teacher-learner” relationship, there is an active mix of traditional and innovative methods, combination of an activity approach with an energy-informational environment approach, cognition with constructivism and connectivism.",book:{id:"5980",slug:"new-pedagogical-challenges-in-the-21st-century-contributions-of-research-in-education",title:"New Pedagogical Challenges in the 21st Century",fullTitle:"New Pedagogical Challenges in the 21st Century - Contributions of Research in Education"},signatures:"Aigerim Mynbayeva, Zukhra Sadvakassova and Bakhytkul\nAkshalova",authors:[{id:"201997",title:"Dr.",name:"Aigerim",middleName:null,surname:"Mynbayeva",slug:"aigerim-mynbayeva",fullName:"Aigerim Mynbayeva"},{id:"209208",title:"Dr.",name:"Zukhra",middleName:null,surname:"Sadvakassova",slug:"zukhra-sadvakassova",fullName:"Zukhra Sadvakassova"},{id:"209210",title:"Dr.",name:"Bakhytkul",middleName:null,surname:"Akshalova",slug:"bakhytkul-akshalova",fullName:"Bakhytkul Akshalova"}]},{id:"61746",title:"Facilitation of Teachers’ Professional Development through Principals’ Instructional Supervision and Teachers’ Knowledge- Management Behaviors",slug:"facilitation-of-teachers-professional-development-through-principals-instructional-supervision-and-t",totalDownloads:3349,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"With the rise of global competition and the focus on teacher quality, teacher professional development is becoming increasingly crucial, and the stress and challenges for principals are more severe than ever. Teachers can improve their professional abilities through principals’ instructional supervision and their own knowledge-management (KM) behaviors to benefit students. Thus, this chapter analyzes the relationship among principals’ instructional supervision, teachers’ KM, and teachers’ professional development. The author believes that principals’ instructional supervision and effective KM can facilitate the professional development of teachers. The author also believes the readers can know the relationships among them, and teachers’ professional development can be improved through principal’s instructional supervision and teachers’ KM behaviors.",book:{id:"6674",slug:"contemporary-pedagogies-in-teacher-education-and-development",title:"Contemporary Pedagogies in Teacher Education and Development",fullTitle:"Contemporary Pedagogies in Teacher Education and Development"},signatures:"Chien-Chin Chen",authors:[{id:"232569",title:"Ph.D.",name:"Chien Chih",middleName:null,surname:"Chen",slug:"chien-chih-chen",fullName:"Chien Chih Chen"}]},{id:"75908",title:"From the Classroom into Virtual Learning Environments: Essential Knowledge, Competences, Skills and Pedagogical Strategies for the 21st Century Teacher Education in Kenya",slug:"from-the-classroom-into-virtual-learning-environments-essential-knowledge-competences-skills-and-ped",totalDownloads:501,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"As teachers in Kenya begin to migrate from the classroom to virtual learning spaces following COVID 19 pandemic, there is pressing need to realign Teacher Education to requisite Knowledge, competences, skills, and attitudes that will support online teaching. This chapter explores these needs using a combination of lived experiences and literature review that captured a meta-analysis of research trends on e-learning. While trends in Teacher Education indicate progression towards adoption of technology, there are disparities between the theory and practice. Evidence from recent research and reports; and the recollected experiences confirmed knowledge, competence, skills and pedagogical gaps in the implementation of online learning, that have been exacerbated by COVID-19. The researcher recommends that teacher education should sensitize and train teacher trainees on how to access, analyze and use new knowledge emerging with technology; they also should be coached on how learners learn with technology and on fundamentals of the communication process. Particularly the course on educational technology, should focus on how to create and manage online courses. The 5-stage E-Moderator Model and Universal Design for Learning (UDL) are recommended as effective pedagogical scaffold for online teaching.",book:{id:"10229",slug:"teacher-education-in-the-21st-century-emerging-skills-for-a-changing-world",title:"Teacher Education in the 21st Century",fullTitle:"Teacher Education in the 21st Century - Emerging Skills for a Changing World"},signatures:"Catherine Adhiambo Amimo",authors:[{id:"333482",title:"Dr.",name:"Catherine Adhiambo",middleName:null,surname:"Amimo",slug:"catherine-adhiambo-amimo",fullName:"Catherine Adhiambo Amimo"}]},{id:"75224",title:"Decoding the Digital Gap in Teacher Education: Three Perspectives across the Globe",slug:"decoding-the-digital-gap-in-teacher-education-three-perspectives-across-the-globe",totalDownloads:552,totalCrossrefCites:0,totalDimensionsCites:4,abstract:"Educational use of technology is regularly assessed, and results often show a gap between educational policies and what is actually practiced. This chapter will help clarify how teacher educators experience the changing educational contexts due to the digital revolution, how their meaning-making shifts, and how outside forces influence those processes. The results are based on comparative international studies. Central for this study is practitioners’ professional digital competence, their attitudes towards digital technology and the use of digital technology in education. We found that the influence and contribution of digital practice is carried out quite differently across the globe. Our research questions were: How do practitioners experience teaching in a rapidly changing context? How do attitudes change due to top-down governing of education? and What motivates teacher educators to implement digital technology?",book:{id:"10229",slug:"teacher-education-in-the-21st-century-emerging-skills-for-a-changing-world",title:"Teacher Education in the 21st Century",fullTitle:"Teacher Education in the 21st Century - Emerging Skills for a Changing World"},signatures:"Steinar Thorvaldsen and Siri Sollied Madsen",authors:[{id:"332624",title:"Associate Prof.",name:"Siri Sollied",middleName:null,surname:"Madsen",slug:"siri-sollied-madsen",fullName:"Siri Sollied Madsen"},{id:"332626",title:"Prof.",name:"Steinar",middleName:null,surname:"Thorvaldsen",slug:"steinar-thorvaldsen",fullName:"Steinar Thorvaldsen"}]},{id:"75416",title:"Self-Study Research: Challenges and Opportunities in Teacher Education",slug:"self-study-research-challenges-and-opportunities-in-teacher-education",totalDownloads:724,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"This article aims to describe what self-study research is, why self-study can be a good approach to teacher educators’ professional development and improvements in practice and highlight some challenges and opportunities in this research approach. In addition, the article will shed light on some methodological aspects related to self-study. Self-study refers to teacher educators who in an intentionally and systematically way examine their practice to improve it, based on a deeper understanding of practice, as well as the context practice takes place. In the article, I argue that engaging in self-study is a learning and development process and an approach to developing personal professionalism, collective professionalism and improvements in practice.",book:{id:"10229",slug:"teacher-education-in-the-21st-century-emerging-skills-for-a-changing-world",title:"Teacher Education in the 21st Century",fullTitle:"Teacher Education in the 21st Century - Emerging Skills for a Changing World"},signatures:"Kåre Hauge",authors:[{id:"332053",title:"Associate Prof.",name:"Kåre",middleName:null,surname:"Hauge",slug:"kare-hauge",fullName:"Kåre Hauge"}]}],onlineFirstChaptersFilter:{topicId:"265",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81937",title:"Socialization Experiences among Undergraduate Students in Higher Learning Institutions (HLI)",slug:"socialization-experiences-among-undergraduate-students-in-higher-learning-institutions-hli-",totalDownloads:20,totalDimensionsCites:0,doi:"10.5772/intechopen.99007",abstract:"This work portrays the problems of socialization among undergraduate students in higher learning institutions. The socialization processes in higher learning institution are significant for the successful navigation of students in the academic programs and university environment in preparing the next generation of professional practitioners and scholars. But the undergraduate student socialization experiences of students at university environment are overlooked. To navigate in the higher learning institutions, students should be socialized effectively to the normative contexts of the higher learning institutions. The normative contexts of the higher learning institutions are generally categorized into social and academic contexts, because these context academic and social context integration have been linked to student retention and success. Social integration involves interpersonal relationships, support, interactions with others, and a sense of belonging at a university, which stems from extracurricular activities, informal dealings with peer groups, and interactions with faculty and staff, whereas academic integration is described through grade performance and intellectual development that reflects an ability to meet the standards of the academic system; intellectual development involves a student valuing their education as a process of development in which they gain knowledge and ideas. Students’ background is also the contributing factor for students’ socialization in the University.",book:{id:"10911",title:"Higher Education - New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg"},signatures:"Mulusew Birhanu Ayalew"},{id:"80280",title:"Adoption of Online Learning during the Covid19 Pandemic Lockdown by Universities in Garowe",slug:"adoption-of-online-learning-during-the-covid19-pandemic-lockdown-by-universities-in-garowe",totalDownloads:88,totalDimensionsCites:0,doi:"10.5772/intechopen.99941",abstract:"In response to the Covid-19 outbreak the world closed and therefore countries like Somalia have not been exceptional. The government of Somalia and all higher education institutions adopted crisis intervention measures on implementation of blended learning approaches like online teaching and learning. In this chapter we explore the process and challenges of adopting online learning in response to the world wide lockdown due to the pandemic. Given that this was an abrupt requirement, the survey was interested in finding out whether universities adopted and adapted easily. Researchers compared findings from previous studies and theoretical inclinations on online learning. Results indicate that the adoption of online learning among universities in Garowe was as a matter of crisis management whereby administration, lecturers and students were all not ready and had no prior grounding in this pedagogical learning platform. Just like previous studies online learning implementers have continued to encounter several challenges like intermittent internet network, cost of gadgets and facilities, inadequate skills of both the instructors and students, aspects of communication and satisfaction from stakeholders. With the research survey in Garowe, results show that this is still pervading and therefore need for more rigorous contextualised research on this subject.",book:{id:"10911",title:"Higher Education - New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg"},signatures:"Tumwebaze Alicon Auf and Omer Abdi Hamdi"},{id:"78597",title:"Public-Private Participation in Funding University Education in Sub-Saharan Africa: A Nigerian Case-Study for Sustainable Development",slug:"public-private-participation-in-funding-university-education-in-sub-saharan-africa-a-nigerian-case-s",totalDownloads:134,totalDimensionsCites:0,doi:"10.5772/intechopen.99940",abstract:"The developing countries in Africa still cannot withstand the pressure of the highly competitive global education market. Together with the large numbers of people who make a living in various innovative companies, these countries have solved key contemporary issues affecting global education. For this reason, it is necessary to actively respond to current technological innovation and educational challenges and to eliminate new technology graduates who can effectively interact with students through the responsive expansion of education and training. Expansion of education can produce effective expansion that promotes educational development, but due to budget constraints, most African governments cannot successfully and sustainably implement such educational programs. This is difficult. However, public-private partnership efforts provide a way out of this financial dilemma. The Sub-Saharan Africa initiative has achieved important educational objectives, such as: ensuring relevance for quality; secure funding for sustainability and establish resource mobilization partnerships and connections; and promote international cooperation. This discussion is relevant to the basic conditions for a successful public-private partnership with educational institutions and extended education and sheds light on the impact, lessons, and challenges. The public is increasingly concerned about the importance of higher education in the 21st century. This chapter explores some of the key functions of an innovative education system that supports the development of education in Nigeria and enhances people’s ability to use information. Nigeria’s education system re-emphasizes the importance of public and private universities, but the country does not have a sustainable education system and well-equipped educational institutions to support people’s ability to use information, learning, education, and research activities.",book:{id:"10911",title:"Higher Education - New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg"},signatures:"Lawrence Jones-Esan"},{id:"79197",title:"University Teachers’ Conceptions of What University Is: Implications for the Future of Higher Education",slug:"university-teachers-conceptions-of-what-university-is-implications-for-the-future-of-higher-educatio",totalDownloads:107,totalDimensionsCites:0,doi:"10.5772/intechopen.100813",abstract:"This chapter presents the perception of university teachers about the university, the most recent changes and how they have influenced their activity. The phenomenographic study was conducted with 10 university teachers, nine females and one male with more than 15 years of professional activity. The perception of the university emerges, in the teachers’ voice, focused on the description of its mission, namely as a context for the production and diffusion of knowledge to society, as a space for creative and critical thinking about the world, as an interdisciplinary space and as a system focused on teaching and research. It also includes characteristics related to its structure and functioning, such as the level of hierarchization, bureaucratization, competitiveness, dehumanization and bibliometrics overvaluation. Regarding the perceived changes, they are related to the structural reforms resulting from the Bologna Process, diverse student populations, research and internationalization, new technologies, institutional cooperation, bureaucratization and relationship with the community. Teachers also revealed some dissatisfaction in the way they are experiencing university life due to the overwork resulting from the multiple tasks required in the four activity strands (teaching, research, management and extension) with an impact on quality and innovation, but in line with what the institution demands.",book:{id:"10911",title:"Higher Education - New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg"},signatures:"Elisa Chaleta"},{id:"78595",title:"Globalization and Education: Trends towards Sustainability",slug:"globalization-and-education-trends-towards-sustainability",totalDownloads:58,totalDimensionsCites:0,doi:"10.5772/intechopen.99974",abstract:"Higher Education Institutions (IES) have a very relevant role in the path towards sustainability. The problem of the implementation of curricular sustainability is the disparity of solutions that can be adopted depending on the political and economic situation of each country. The study of a practical case in the south of Honduras allows the student to approach key decisions in a real scenario to bring improvements to a very disadvantaged population, lacking basic services, such as water and electricity, under the premise of sustainability, facing aspects as relevant such as sustainable mobility, water resources management, energy and construction models, in a context where globalization and technological innovation play a very important role. It is essential to know in depth the real context where structural changes will be applied to understand that there is no single reality, that actions are built adapting to specific situations and that the effectiveness of the measures that can be adopted to establish models that prioritize that part of sustainability that best weighs the balance between the environment, society and the economy for each case.",book:{id:"10911",title:"Higher Education - New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg"},signatures:"Maria Olga Bernaldo and Gonzalo Fernandez-Sanchez"},{id:"79255",title:"Higher Education Institutions (HEIs) in Africa Embracing the “New Normal” for Knowledge Production and Innovation: Barriers, Realities, and Possibilities",slug:"higher-education-institutions-heis-in-africa-embracing-the-new-normal-for-knowledge-production-and-i",totalDownloads:128,totalDimensionsCites:1,doi:"10.5772/intechopen.101063",abstract:"If Africa is to remain relevant and competitive in today’s knowledge-based economy, it has to rely on higher education institutions (HEIs) as centers of excellence for knowledge production. HEIs nurture and sustain the production of highly-skilled individuals to support Africa’s growing economies. Among all possible ways, this could be achievable through strategic curricula innovation driven by emerging mobile technologies. Consequently, Africa’s HEIs need to embrace the ‘New Normal’ by optimizing online teaching and learning in their pursuit to expand information and communications technology (ICT) literacy as a means to increase students’ opportunities in higher education (HE). However, Africa’s ability to embrace the ‘New Normal’ has been marred by inadequate ICT infrastructures, low connectivity, unreliable power supply, and national budget constraints that may undermine Africa’s HEIs’ potential to augment knowledge production and innovation.",book:{id:"10911",title:"Higher Education - New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg"},signatures:"Christopher B. 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His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. 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In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. 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He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. from Integral University, Lucknow, India, with his work titled ‘Development and evaluation of silymarin nanoformulation for hepatic carcinoma’. Currently, he is an Assistant Professor of Pharmaceutics, at the Faculty of Pharmacy, Integral University. He has been teaching PharmD, BPharm, and MPharm students and conducting research in the novel drug delivery domain. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than twenty-four original journal articles, two edited books, four book chapters, and several scientific articles to his credit. He is a member of the American Association for Cancer Research, the International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"333824",title:"Dr.",name:"Ahmad Farouk",middleName:null,surname:"Musa",slug:"ahmad-farouk-musa",fullName:"Ahmad Farouk Musa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333824/images/22684_n.jpg",biography:"Dato’ Dr Ahmad Farouk Musa\nMD, MMED (Surgery) (Mal), Fellowship in Cardiothoracic Surgery (Monash Health, Aust), Graduate Certificate in Higher Education (Aust), Academy of Medicine (Mal)\n\n\n\nDato’ Dr Ahmad Farouk Musa obtained his Doctor of Medicine from USM in 1992. He then obtained his Master of Medicine in Surgery from the same university in the year 2000 before subspecialising in Cardiothoracic Surgery at Institut Jantung Negara (IJN), Kuala Lumpur from 2002 until 2005. He then completed his Fellowship in Cardiothoracic Surgery at Monash Health, Melbourne, Australia in 2008. He has served in the Malaysian army as a Medical Officer with the rank of Captain upon completing his Internship before joining USM as a trainee lecturer. He is now serving as an academic and researcher at Monash University Malaysia. He is a life-member of the Malaysian Association of Thoracic & Cardiovascular Surgery (MATCVS) and a committee member of the MATCVS Database. He is also a life-member of the College of Surgeons, Academy of Medicine of Malaysia; a life-member of Malaysian Medical Association (MMA), and a life-member of Islamic Medical Association of Malaysia (IMAM). Recently he was appointed as an Interim Chairperson of Examination & Assessment Subcommittee of the UiTM-IJN Cardiothoracic Surgery Postgraduate Program. As an academic, he has published numerous research papers and book chapters. He has also been appointed to review many scientific manuscripts by established journals such as the British Medical Journal (BMJ). He has presented his research works at numerous local and international conferences such as the European Association for Cardiothoracic Surgery (EACTS) and the European Society of Cardiovascular Surgery (ESCVS), to name a few. He has also won many awards for his research presentations at meetings and conferences like the prestigious International Invention, Innovation & Technology Exhibition (ITEX); Design, Research and Innovation Exhibition, the National Conference on Medical Sciences and the Annual Scientific Meetings of the Malaysian Association for Thoracic and Cardiovascular Surgery. He was awarded the Darjah Setia Pangkuan Negeri (DSPN) by the Governor of Penang in July, 2015.",institutionString:null,institution:{name:"Monash University Malaysia",country:{name:"Malaysia"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}}]}},subseries:{item:{id:"6",type:"subseries",title:"Viral Infectious Diseases",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11402,editor:{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. 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In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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