Definitions of sow sexual behavior when she is in estrus.
\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"10216",leadTitle:null,fullTitle:"Paraffin - Thermal Energy Storage Applications",title:"Paraffin",subtitle:"Thermal Energy Storage Applications",reviewType:"peer-reviewed",abstract:"This book, Paraffin - Thermal Energy Storage Applications, includes 6 chapters that focus on thermal energy storage. It examines the preparation of paraffin via encapsulation to develop a nonconventional energy storage material.",isbn:"978-1-83968-706-8",printIsbn:"978-1-83968-705-1",pdfIsbn:"978-1-83968-707-5",doi:"10.5772/intechopen.90983",price:119,priceEur:129,priceUsd:155,slug:"paraffin-thermal-energy-storage-applications",numberOfPages:106,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"456090b63f5ba2290e24e655abd119bf",bookSignature:"ElSayed G. Zaki and Abdelghaffar S. Dhmees",publishedDate:"April 20th 2022",coverURL:"https://cdn.intechopen.com/books/images_new/10216.jpg",numberOfDownloads:845,numberOfWosCitations:0,numberOfCrossrefCitations:2,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:3,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:5,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 28th 2020",dateEndSecondStepPublish:"December 1st 2020",dateEndThirdStepPublish:"January 30th 2021",dateEndFourthStepPublish:"April 20th 2021",dateEndFifthStepPublish:"June 19th 2021",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"220156",title:"Dr.",name:"ElSayed G.",middleName:null,surname:"Zaki",slug:"elsayed-g.-zaki",fullName:"ElSayed G. Zaki",profilePictureURL:"https://mts.intechopen.com/storage/users/220156/images/system/220156.jpg",biography:"Dr. Elsayed Zaki received his Ph.D. in Physical Chemistry from the Department of Chemistry, Faculty of Science, Mansoura University, Egypt. Currently, he is a visiting researcher at the Department of Chemical and Biomolecular Engineering, Iacocca Hall, Lehigh University, Pennsylvania, USA. He is an Associate Professor of Applied Chemistry in the Petroleum Applications Department, Egyptian Petroleum Research Institute. He is currently an editorial board member for several reputed journals, a member of the Synchrotron-light for Experimental Science and Applications in the Middle East (SESAME), Organization for Women in Science for the Developing World (OWSD), and the International Union of Pure and Applied Chemistry (IUPAC).",institutionString:"Egyptian Petroleum Research Institute",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Egyptian Petroleum Research Institute",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"278721",title:"Dr.",name:"Abdelghaffar",middleName:"S.",surname:"Dhmees",slug:"abdelghaffar-dhmees",fullName:"Abdelghaffar Dhmees",profilePictureURL:"https://mts.intechopen.com/storage/users/278721/images/system/278721.png",biography:"Dr. Abdelghaffar Dhmees has been working as an assistant professor at the Department of Analysis & Evaluation, Egyptian Petroleum Research Institute, Egypt. He obtained a Ph.D. in 2015 with a thesis on the valorization of industrial waste to heterogeneous catalysts for biodiesel production. He is currently working on the synthesis of advanced 2D materials (e.g., MoS2, graphene, LDH, and its composites) for application in energy storage and valorization of industrial waste and byproducts for the synthesis of adsorbents, catalysts, membranes, and photocatalysts for application in water treatment, petroleum stream purification, and biofuel production.",institutionString:null,position:null,outsideEditionCount:null,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Egyptian Petroleum Research Institute",institutionURL:null,country:{name:"Egypt"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"767",title:"Petrochemical Engineering",slug:"engineering-energy-engineering-petrochemical-engineering"}],chapters:[{id:"81008",title:"Advancement in Energy Storage by Paraffin",doi:"10.5772/intechopen.104401",slug:"advancement-in-energy-storage-by-paraffin",totalDownloads:23,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Paraffin uses in energy storage depends on preparation by encapsulation method become more effective nonconventional technique novel storge material. Many measurements as hydrophilicity, energy storage capacity, size distribution and encapsulation ratio can be evaluated. It was also found that a higher coating to paraffin ratio leads to a higher paraffin encapsulation ratio. The hydrophilicity value of microencapsulated paraffin depended mainly on the ratio of paraffin to coating the higher the ratio, the lower was its product hydrophilicity Surface response method used to design and based conditions to optimize it. Using paraffin in energy storage in the future is promising.",signatures:"ElSayed G. Zaki, Shimaa M. Elsaeed and Abdelghaffar S. Dhmees",downloadPdfUrl:"/chapter/pdf-download/81008",previewPdfUrl:"/chapter/pdf-preview/81008",authors:[{id:"220156",title:"Dr.",name:"ElSayed G.",surname:"Zaki",slug:"elsayed-g.-zaki",fullName:"ElSayed G. Zaki"},{id:"278721",title:"Dr.",name:"Abdelghaffar",surname:"Dhmees",slug:"abdelghaffar-dhmees",fullName:"Abdelghaffar Dhmees"},{id:"221310",title:"Prof.",name:"Shimaa",surname:"Elsaeed",slug:"shimaa-elsaeed",fullName:"Shimaa Elsaeed"}],corrections:null},{id:"77287",title:"Latent Heat Storage: An Introduction",doi:"10.5772/intechopen.98485",slug:"latent-heat-storage-an-introduction",totalDownloads:159,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter includes an introduction to thermal energy storage systems. It lists the areas of application of the storage. It also includes the different storage systems; sensible, latent, and chemical. It concentrates on the concept and the application of latent thermal storage. A detailed overview of the energy storage capacity of latent systems is discussed. The motivation and the challenge to incorporate phase change materials in the storage system are highlighted. Next, a classification of different phase change materials (PCMs) and their applicability in different temperature ranges of operations are analyzed. A thorough review will be presented for its industrial applications.",signatures:"Hebatallah Teamah",downloadPdfUrl:"/chapter/pdf-download/77287",previewPdfUrl:"/chapter/pdf-preview/77287",authors:[{id:"338317",title:"Prof.",name:"Hebatallah",surname:"Teamah",slug:"hebatallah-teamah",fullName:"Hebatallah Teamah"}],corrections:null},{id:"76177",title:"Paraffin Wax-Based Thermal Composites",doi:"10.5772/intechopen.97195",slug:"paraffin-wax-based-thermal-composites",totalDownloads:207,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Paraffin waxes are organic phase change materials possessing a great potential to store and release thermal energy. The reversible solid–liquid phase change phenomenon is the under-lying mechanism enabling the paraffin waxes as robust thermal reservoirs based on inherently high latent heat (i.e., ~200–250 J/g). However, the main drawback of paraffin waxes is their inability to expedite the phase change process owing to low thermal conductivity (i.e., ~0.19–0.35 Wm−1 K−1). This drawback has long been documented as a technological challenge of paraffin waxes especially for temperature-control applications where faster thermal storage/release is necessitated, encompassing thermal management of batteries, thermoelectric modules and photovoltaic panels. Besides, sustaining the solid-like form of paraffin waxes (shape-stability) is also recommended to avoid the liquid drainage threats for crucial applications, like thermal management of buildings and fabrics. These objectives can be met by developing the paraffin wax-based thermal composites (PWTCs) with help of various thermal reinforcements. However, PWTCs also encounter severe challenges, probably due to lack of design standards. This chapter attempts presenting the recent advances and major bottlenecks of PWTCs, as well as proposing the design standards for optimal PWTCs. Also, the fundamental classification of phase change phenomenon, paraffin waxes and potential thermal reinforcements is thoroughly included.",signatures:"Gulfam Raza, Saqib Iqbal and Abdul Samad Farooq",downloadPdfUrl:"/chapter/pdf-download/76177",previewPdfUrl:"/chapter/pdf-preview/76177",authors:[{id:"346036",title:"Dr.",name:"Gulfam",surname:"Raza",slug:"gulfam-raza",fullName:"Gulfam Raza"},{id:"353171",title:"Dr.",name:"Saqib",surname:"Iqbal",slug:"saqib-iqbal",fullName:"Saqib Iqbal"},{id:"353172",title:"Mr.",name:"Abdul Samad",surname:"Farooq",slug:"abdul-samad-farooq",fullName:"Abdul Samad Farooq"}],corrections:null},{id:"75053",title:"CFD Model of Shell-and-Tube Latent Heat Thermal Storage Unit Using Paraffin as a PCM",doi:"10.5772/intechopen.95847",slug:"cfd-model-of-shell-and-tube-latent-heat-thermal-storage-unit-using-paraffin-as-a-pcm",totalDownloads:136,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter validates the capability of CFD modelling technique to accurately describe processes in the thermal storage system with the PCM. For validation purposes, CFD modelling using FLUENT ANSYS was conducted and the predicted results were compared with the experimental and numerical data from the literature. The comparison between experimental and numerical results was carried out in terms of the temperature distributions and average volume of the PCM liquid fraction. Additionally, the detailed parametric study of the storage system with the PCM was performed and results obtained were discussed with dimensional correlations for the Nusselt number being proposed to be used in the designing process. Finally, a correlation was developed to estimate the total melting time at the thermal storage system.",signatures:"Maher Mohammad Al-Maghalseh",downloadPdfUrl:"/chapter/pdf-download/75053",previewPdfUrl:"/chapter/pdf-preview/75053",authors:[{id:"249192",title:"Dr.",name:"Maher",surname:"Mohammad Al-Maghalseh",slug:"maher-mohammad-al-maghalseh",fullName:"Maher Mohammad Al-Maghalseh"}],corrections:null},{id:"75962",title:"Solidification and Melting of Phase Change Material in Cold Thermal Storage Systems",doi:"10.5772/intechopen.96674",slug:"solidification-and-melting-of-phase-change-material-in-cold-thermal-storage-systems",totalDownloads:176,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Cold thermal storage can be used to manage peak load when the energy demand is exceeding the capacities of the electric companies. Latent heat thermal storage is more effective because it requires less spacing and has higher thermal capacity than other types. Solidification and melting are taking place in CTS and need more investigation for better performance. Phase change materials properties vary and need more investigation to select the most suitable for a certain application. The analytical equations are needed for design of CTS and get the maximum efficiency out of it. Cost effectiveness is also described.",signatures:"Hani Hussain Sait",downloadPdfUrl:"/chapter/pdf-download/75962",previewPdfUrl:"/chapter/pdf-preview/75962",authors:[{id:"246757",title:"Prof.",name:"Hani",surname:"Hussain Sait",slug:"hani-hussain-sait",fullName:"Hani Hussain Sait"}],corrections:null},{id:"75989",title:"News Aspects Theoric and Experimental to Paraffins Compounds",doi:"10.5772/intechopen.96906",slug:"news-aspects-theoric-and-experimental-to-paraffins-compounds",totalDownloads:146,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The paraffinic compounds are important to new investigation on the properties physics and its correlation with theoric dates, because in literature no is completely clarified. However, there are some studies on the formalism for developing asymptotic behavior correlation for homologous series paraffin compounds. In this work is show that the effect of parameters theoric obtained by molecular modeling can be correlated with experimental dates. To paraffins as pure, for example, n-hexane, C6H14, MW 158 g/mol, is composed of two groups CH3 and four groups CH2 and its can depending of structure molecular ramification to predict what your dependency with thermodynamics data. Therefore, the molecular modeling of paraffinic compounds uses a methodology that looks for data correlated with the structure of the molecule complemented with experimental data. 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\r\n\tHuman-Robot Interaction (HRI) is defined as a field of study that is committed to realizing, creating, and testing robotic systems that interact with humans. HRI has emerged as a significant area of research due to its diverse applications in personal and societal domains.
\r\n\r\n\tThis book aims to present recent advances in this emerging area. More specifically, the book aims to look at research methods and domains in HRI including collaborative robots, humanoid robots, telerobotics, design and control, adaptation, and learning. The book also aims to look at some promising current and future applications of HRI including space, military, medical, personal, and societal applications. We welcome other novel applications that are not mentioned here.
\r\n\r\n\tThe book aims to close with some anticipated challenges in HRI and their integration into society. These challenges include standardizations, design evaluations, testing and validation, and contextualization. Overall, the goal of this book is to present comprehensive coverage from the contributions of leading researchers in this flourishing field of HRI.
",isbn:"978-1-80356-411-1",printIsbn:"978-1-80356-410-4",pdfIsbn:"978-1-80356-412-8",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"2003e3388833e911f610e0cd9788a5e7",bookSignature:"Dr. Ramana Vinjamuri",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11458.jpg",keywords:"Collaborative Robots, Humanoid Robots, Design and Control, Adaptation, Learning, HRI in Space, Military Applications, Medical Applications, Challenges in Human Robot Interaction, Standardizations, Testing and Validations, Contextualization",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 24th 2022",dateEndSecondStepPublish:"March 24th 2022",dateEndThirdStepPublish:"May 23rd 2022",dateEndFourthStepPublish:"August 11th 2022",dateEndFifthStepPublish:"October 10th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Dedicated, resourceful, and innovative researcher in human-centered computing, robotics, and brain-machine interfaces, IEEE Senior Member and holder of two registered patents.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",slug:"ramana-vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",biography:"Ramana Vinjamuri received a Ph.D. in Electrical Engineering with a specialization in dimensionality reduction in control and coordination of human hand from the University of Pittsburgh, Pennsylvania, in 2008. From 2008 to 2012, he worked as a postdoctoral research associate in the field of Brain-Machine Interfaces (BMI) to control prostheses at the School of Medicine, the University of Pittsburgh, where he received the Mary E Switzer Merit Fellowship from the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR) in 2010. From 2012 to 2013, he worked as a research assistant professor in the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, in the area of neuroprosthetics. He also worked as an assistant professor in the Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, New Jersey, from 2013 to 2020. He holds a secondary appointment as an adjunct assistant Professor at the Indian Institute of Technology, Hyderabad, India. He is currently an assistant professor in the Department of Computer Science and Electrical Engineering, University of Maryland, USA.\n\nIn 2018, Dr. Vinjamuri received the Harvey N Davis Distinguished Teaching Award for excellence in undergraduate and graduate teaching. He also received the National Science Foundation (NSF) CAREER Award in 2019 and an NSF Industry-University Cooperative Research Centers (IUCRC) Planning Grant in 2020. 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From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. 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However, the main research goal of the transparent conducting films (TCF) and materials has been rapidly promising to scientists as well as industries. This continuing transformation is taking place at all levels: technologies, applications, developers and suppliers. Owing to their processability, stability, and high conductivity, carbon nanotubes has received significant attention from electronics-industry researchers over the past several years as an alternative to ITO. As per current trends for transparent conductive films increases, transparent electrode materials alternatives to ITO and active research and development for commercialization of such materials are being conducted. Meanwhile, transparent conductive films that have conductivity while being transparent are heavily used as essential elements for touch panels of smartphones or tablets or transparent electrodes of solar cells or other products. In particular entitled book “Transparent Conducting Films”, we provide the most comprehensive and authoritative chapters are based upon years of research as we have been tracking and analyzing TCF industry since 2008. Those useful chapters are listed below in contained book;
Carbon nanotube transparent conducting film
Carbon nanotube activated thin-film transparent conductor applications
Conductive polymers in biosensors
Nanocarbon-based transparent conducting films
Our expert team of reviewers and editors has also been independently analyzed and peer reviewed those individual articles to flourish emerging target applications. Indeed, most of the articles, particularly concentrated on OLED lighting, wearable technology, in-mold electronics, smart windows, OPVs, DSSCs, perovskites, and touch screens. This enables us to assess the market from an application as well as technology point of view. The approach mainly the author used for fabrication is highly reproducible and creates a chemically stable configuration with a tunable tradeoff between transparency and conductive properties. In the new study, the contributors used an approach called colloidal lithography to create transparent conductive silver thin films.
If researchers would like to get specific knowledge on this topic from the beginning, the best advice would be to choose firstly the branch among an incomprehensible canopy of transparent conducting films and its various applied studies [1, 2]. The book aimed to show how the field is studied in different countries and what is common for all spectroscopic or microscopic investigations. The results from these experimental studies are very important outcomes of model experiments carried out on cultivating thin film techniques.
The phase, purity, stability and morphology of the composite and its constitutes have been also analyzed in those chapters. Hence, it possesses superior thermal properties and higher thermal stabilities of its layers [3, 4], qualifying it to be used in various thermo-electric devices [5] and photovoltaics. Indeed, the optical properties can be studied by utilizing optical absorption spectrum calculated optical energy band gap of the conducting film [6, 7]. The electrical parameters such as dielectric constant, tangent loss, AC conductivity as a function of frequency with fixed typical temperature also analyze.
The overall studies and investigated results in our individual chapter. Through the entire book in this year will get scope to learn more about the market trends, the key questions, latest prices, novelty of applications, e.g., transparent electrodes, flexible displays or wearable devices, OPV (organic photovoltaics) cells, light control glasses or films, organic EL lighting, transparent antennas, transparent electric wave shielding materials, and fine-tuned our analysis, insight and forecasts to reflect the latest research.
We also believe that it will be most help beginner research scholars, scientists, academicians in current understanding and advise them quite novel and non-standard approaches to find and decipher the mechanisms of transparent conducting film methodology and its application.
Finally, we would like to thank all the concern authors for their endless contributions and hard work to match and unify the “philosophy” of this book. We also thank to our colleagues from University Federal Rio de Jenerio, Brazil and Mahatma Gandhi University, Kerala, India who supported us and helped us in preparation and edition of the chapters, especially to those who raised complex questions and promoted us to answer them. We are personally very grateful to the “In-Tech” Publisher, especially Ms. Anita Condic, who assisted us in the arrangement of the book and scheduling our activities.
In 2018 the world had over 700 million pigs with over half of them in China [1]. With the recent spread of African Swine Fever (ASF) in China and other parts of Asia, the pig population has rapidly declined. At the same time, movement of breeding animals is restricted in the most pig-dense continent and so rebuilding pig numbers is a challenge. When diseases like ASF break out, and breeding animal movement is restricted, then some sows must be bred without the use of adult males. Successful pig breeding is the key to maintaining and restoring pig numbers and the world’s supply of pork.
\nIn cattle herds and poultry flocks, successful breeding often takes place without any adult males. In contrast, most commercial pig farms have adult male pigs (boars) on site to maintain optimum breeding success. Thus, the pig is unique among common food animals in requiring the presence of adult males in commercial production. While some sows will express sexual behaviors without a boar, to get the majority of sows bred, in current commercial production, the male is thought to be required.
\nIn less developed countries, pigs may roam free and are harvested as desired, but these represent a smaller percentage of the world pig inventory over time. Some commercial pigs are kept outdoors in managed systems. The outdoor production system (Figure 1, left) represents a small part of the world’s pig herd. Most pigs in the world used for pork production are kept on commercial farms using an indoor sow housing system. The most common method of housing the breeding sow is in a crate or pen (Figure 1, right) [2]. The breeding crate is large enough (often 0.6 m × 2.1 m) to accommodate the body of the sow but the breeding crate does not allow the sow to turn around or to express her full repertoire of behaviors. The method of keeping breeding sows (outdoor, indoor in pens or crates) clearly impacts their ability to express natural sexual behaviors and the breeding crate reduces the likelihood of successful mating. Sexual behaviors are best observed in freely-moving sows and boars, but the reality of commercial pork production is that sows are in a breeding crate in which they may have limited fence line contact with an adult male—and this makes training of workers challenging. A better understanding by farm workers of sow and boar sexual behaviors will meaningfully improve reproductive success.
\nOutdoor systems with natural mating (left) are less common today. Sow in a breeding crate or stall (right). The breeding crate is the most common indoor breeding system. Note that in the outdoor, natural mating system, the sow and boar can fully interact. However, in the breeding crate, a person applies back pressure in the presence of a boar to induce sexual behaviors when a sow is in estrus. If the sow is not in estrus, she will not show sexual behaviors when the person applies pressure to her back.
The objectives of this chapter are first to review the basic behavioral biology of sexual behavior and reproductive success in the domestic pig. Secondly, this chapter will summarize classic literature on sow and boar sexual behaviors and will review both applications of pheromone technologies and mechanisms by which pheromones can improve reproductive performance in the pig herd. To have a better understanding of pig sexual behaviors and of the impact of the boar sexual pheromone on female reproduction, we will also review pig olfactory system anatomy and physiology.
\nWhile pig farmers have observed sexual behavior for millennia, the earliest scientific description of sow sexual behavior in the scientific literature was in 1941 by Altmann [3]. Altmann was a psychologist at the University of Chicago when animal behavior was developing in the USA. Altmann studied female pig sexual behavior because she used pigs in her conditioning studies, and she wanted to be sure if sows were or were not in heat when she trained them on an operant task. In 1941, she reported several aspects of sow sexual behavior that we know to be true. She said there was a 18–23 day cycle among adult females. She indicated that domestic sows (unlike wild boar) bred year-round, although they often had a “silent heat” in warm weather. She found external signs of estrus to be not reliable indicators of estrus; these included, vaginal mucous, swelling of the vulva and rectal temperature changes. We recently confirmed her observations with quantification of anatomical changes (see below). She indicated behavior and activity were the best methods to determine heat, but a combination of methods increased accuracy.
\nThe next scientist to publish studies in pig sexual behavior was Jean Pierre Signoret from France. His research on sow sexual behavior in the 1960s and early 1970s were summarized in a chapter Signoret co-wrote in Hafez’s 1964/1968/1975 editions of the book “The Behaviour of Domestic animals” [4]. The picture of sow-boar sexual behavior in that chapter has been widely used to describe pig’s sexual behavior. In that picture, he lists sequences of boar-sow behaviors that are shown in Figure 2. The sequence of sexual behaviors between a sow and boar include mutual head sniffing, and then the boar sniffs the sow’s rear, he then pushes and may lift the sow from the side, then he sniffs and licks and pushes on the sow’s rear. These olfactory and tactile behaviors are accompanied by grunting by the boar and, if the sow is in estrus, she will be silence or she will make soft rhythmic grunts in response (she will squeal if she is not in estrus as a form of objecting to the boar behavior). After touching, smelling and licking her rear, he will mount her and if she is fully in estrus and showing “standing reflex or locked up” behavior, he will copulate with her.
\nDrawings of sow-boar sexual behaviors from Signoret [
We present in Table 1 our definitions of sow sexual behaviors that are observed while a sow is in a breeding crate. Note that because her movements and boar interaction are restricted while in a breeding crate, she will not express the same number of behaviors as in the wild. When the sow expresses intense standing still, we say she is “locked up.” A sow can stand still for a few seconds at any time and not be locked up or in estrus. Being locked up is the primary and only reliable sign that a sow is in estrus.
\nWord | \nDefinition | \n
---|---|
Standing still | \nAlso called standing posture, the sow is motionless for intervals no greater than 10 consecutive seconds | \n
Standing reflex, locked up | \nWhen a sow stands still for more than 10 consecutive seconds, usually by applying back pressure. This behavior is exhibited by sows when they see the boar, during the back-pressure test, or when being mounted. Sometimes displayed together with pricked ears and muscle contraction (rigid muscles and in some sow muscle shaking) | \n
Latency to lock up | \nTime in seconds from application of back pressure until the sow locks up. When a sow is in estrus, latency is usually less than 30 s | \n
Pricked ears | \nLifting ears from resting position, usually while sniffing and exhibiting sexual interest. Ears either stand straight up or are obviously higher than resting | \n
Moving | \nBefore and after full estrus, sows will move when back pressure is applied | \n
Sniff | \nWhen a boar is near or when they experience a pheromone, they move their rooting disk as they sniff (see videos) | \n
Chomping | \nWhen the sow has nose-to-nose contact with a boar, or if they experience the complete pheromone, they will open and close their mouth, and move their tongue in and out while they keep their head level or elevated so they can apply the liquid to their VNO | \n
Vocalization—stress | \nSows express a high-pitch squeal when they are objecting to back pressure or a boar. This is a stress vocalization sows make when are not in estrus | \n
Vocalization—“chatting” or “chanting” with the “boar” | \nThe sow grunts in a low-pitch repeated manner when she sees, smells or hears a boar. This vocalization is not expressed by all sows | \n
Definitions of sow sexual behavior when she is in estrus.
We use these and related definitions in our recent work.
The boar is non-discriminating when deciding which animal or object to mount. The boar will attempt to mate sows not in estrus and they will mate an object shaped roughly like a sow (e.g., a boar semen collection dummy)—anything shaped like a cylinder that stands still will be mounted by an adult boar.
\nIf the sow is not in full estrus, she will avoid the boar. If she experiences an adult boar while not in heat, then she will vocalize (squeal) and be aggressive towards him to express her objection. In the author’s personal observations of feral pigs and outdoor pigs allowed to mate naturally, a sow not in estrus is very aggressive towards adult males. With the matriarchal social structure in nature, the sow is clearly dominant to the boar, except when she is in estrus.
\nIn the period of proestrus, the sow is becoming interested in the boar, but she will still not be willing to stand still for mounting. In this period, she will seek a boar, interact with him and allow for mutual sensory exploration. When these behaviors are observed and the BPT is administered, the sow will not stand still. This period is referred to on the farm as a sow that is coming into estrus but not fully in estrus (proestrus).
\nIn a breeding crate, the most noticeable sexual behaviors expressed by a sow are locked up and pricked ears (see Table 1 for definition). Stock people that breed sows will be familiar with these sexual behaviors. However, we recognize that there is considerable variation in sexual behaviors within genetic lines and among genetic lines (and breeds). Some individual sows show more extreme sexual behaviors and some show only mild signs of being in estrus. Video in the following link (https://youtu.be/DdgxK1U8ZUo) shows a sow with a strong sexual behavioral response after boar exposure. Video in the following link (https://youtu.be/tspB7RkviBo) shows the same sow that expresses sexual behavior after application of the new boar pheromone [5]. Note the locked up behavior, sniffing and chomping by the sow.
\nCommercial farms must train workers who perform artificial insemination (AI). Pig breeders must understand sow sexual behavior to achieve success. With training and experience, the AI technician can achieve very high breeding and farrowing rates, but rarely 100% of sows are bred and remain pregnant. Training workers is challenging because sows vary widely in their sexual behaviors. AI workers must be trained with the specific genetic line of pig they are expected to breed. They must understand what normal sexual behavior is for that genetic line and then how to modulate that behavior to achieve high levels of reproductive success. Training is challenging because sows in breeding crates are not able to express the full repertoire of sexual behaviors that they express in an open area and boars are not able to stimulate crated sows through olfactory and tactile senses as they can for penned or pastured pigs.
\nThe sow estrus cycle is of 18–24 days long [6], with the median and mode of 21 days. Sows are polyestrous animals. This means that with the appropriate nutrition, good health, and the proper environmental conditions, sows will cycle through the year. The sow estrus cycle is only stopped by pregnancy or lactation, and possibly old age. In sows, lactational anestrus is due to the inhibition of the GnRH pulse by the suckling stimulus [7]. Gilts reach puberty at 5 or 6 months old. For sows, the first estrus post-weaning takes place 4–7 days after weaning for most, but not all sows (some have a longer or shorter wean to estrus interval).
\nDuring the estrous cycle, sow’s hormones change. The hormonal changes mark the different stages of the estrus cycle. The sow estrus cycle is divided in two main phases, follicular and luteal. These phases are further divided into four stages. The follicular phase is divided into proestrus and estrus, while the luteal phase is divided into metestrus and diestrus.
\nFor our discussion, we will assume that the first day of estrus is day 0 of the cycle (Figure 3). The onset of estrus is mainly caused by an increase in estrogens. Sow estrus usually last 40–60 h (from day 0 to day 1–2 of the cycle) [6] but some sows can be on estrus for longer. Sow will only show sexual behaviors and accept the boar during the estrus stage of the cycle. During estrus, estrogen, Follicle stimulating hormone (FSH) and Luteinizing hormone (LH) secretion peaks. During estrus, ovulation is caused by the LH surge. Ovulation occurs 30–40 h after estrus onset [6].
\nSchematic of the timing of ovulation with associated hormonal and behavioral changes. Weaning is at time zero. From Pedersen [
Almost immediately after ovulation, sow will enter the luteal phase. During the metestrus stage of the luteal phase (days 2–5 of the cycle), the follicle tissue will start its development into a corpus luteum. This process is called luteinization [6]. The end of metestrus and the beginning of diestrus is marked by the end of the luteinization process. Diestrus is the longest stage of the estrus cycle. It starts once the corpus luteum is formed and last for 12–15 days after (days 6–17 of the cycle). The corpus luteum will secret progesterone to prepare the uterus for implantation and to maintain pregnancy in case of successful fertilization by the boar or artificial insemination. If the sow is not pregnant, the uterus will start secreting prostaglandin F2 alpha and luteolysis (degradation of the corpus luteus) will start after 15 days post ovulation (proestrus stage) [6]. Proestrus (day 17–21 of the cycle) is characterized by an increase in prostaglandin F2 alpha secretion and the completion of luteolysis. During this phase, progesterone secretion is reduced and estrogen, then LH, and FSH secretion increase. This increase will re-start estrus.
\nThe introduction of assisted reproductive techniques, such as Artificial Insemination, has shifted the responsibility of estrus detection to humans with the assistance of a live boar. The traditional way to identify if a sow has come into heat and is ready to be breed, is based on the occurrence of sexual behaviors before, during or after the backpressure test (BPT) and by detecting physical changes in sow vulva. Physical changes associated with the onset of estrus are reported to include vulva reddening, increase in vulvar temperature, the presence of sticky mucus, and an increase in vulva size often refer as swelling.
\nLangendijk et al. [6] found that out of 130 sows only 87% showed an increase in internal vulva redness. In this study, they also found a significant variation on the time vulva reddening occurred. Even when reddening onset varied between individual sows, it always occurred before ovulation. Thus, they suggest that insemination of sows that shows vulva reddening should be delayed until the end of vulva reddening.
\nThe increase in vulva size and infrared temperature observed during estrus have been correlated to the high estrogen levels during estrus. The elevated levels of estrogen increase the vaginal and vulvar blood flow resulting in both an increase in vulva temperature as well as vulva swelling [9]. The literature is contradictory related to vulva features. Sykes et al. [9] and Scolari et al. [10] found that the infrared vulva temperature increased by 1 C° the day of estrus whereas Simoes et al. [11] found that the temperature increase was during the proestrus period.
\nUn-published studies recently conducted by the authors showed that not all sows will show these physical changes. We carefully measured color, size, surface temperature and vaginal temperature in sows before and during estrus (Table 2). Sows might show these physical changes at a different stage of the estrus cycle. Because not all sows will show changes in vulva color, temperature, or size during estrus, the onset of these changes varied among individual animals. Vulva physical and thermal changes are not reliable indicators for heat checking for all sows of use on the farm.
\nMeasurement | \nDay when the change was visible | \n|||
---|---|---|---|---|
Day before estrus | \nFirst day of estrus | \nDay after first day of estrus | \nNo change | \n|
Vulva reddening | \n31.82% | \n18.18% | \n13.64% | \n36.36% | \n
Vulva IR temperature | \n4.55% | \n59.09% | \n9.09% | \n27.27% | \n
Vaginal temperature (C˚)\n*\n\n | \n0.00% | \n15.38% | \n0.00% | \n84.61% | \n
Vulva swelling | \n31.82% | \n13.64% | \n0.00% | \n54.55% | \n
Presence of sticky mucus | \n40.91% | \n36.36% | \n22.73% | \n0.00% | \n
Proportion of sows (
\n
The percentage figures refer to the % of sows that first show that feature on each day.
Myometrial activity before and after estrus is either absent or of low amplitude and frequency [12, 13]. During estrus, sow myometrial electrical activity and contraction frequency and amplitude increase [12]. Myometrial contractions are regulated by progesterone, oxytocin, and estrogen concentrations [14]. High progesterone reduces uterine contractions whereas high oxytocin and estrogen levels increase them [14]. Oxytocin and estrogen secretion increase during estrus and sexual stimulation and arousal, although direct neuromuscular activation could be via the brain and spinal nerves. In vitro studies found that after an estrogen perfusion, there was a significant increase in peristalsis going from the isthmus uteri towards the corpus uteri [15]. Similar results were found with an oxytocin perfusion [15]. Uterine contractions are necessary for the movement of sperm from the uterus to the fallopian tubes. This could explain why seminal oxytocin and estrogen increase uterine contractions [12]. Boar presence induces sow oxytocin release and increases sow’s myometrial activity [12]. The effects of each individual boar stimulus (olfactory, tactile, and visual) on oxytocin release are still not clear [12].
\nSome sows will also show skeletal muscle contraction that one would call shaking during the standing reflex. From our behavioral studies, we estimated that fewer than one in ten sows will show this behavior. Skeletal muscle movement can be easily perceived on sow shoulders, flank, neck and ears.
\nTo continue the production cycle and swine sustainability, sows need to be replaced by gilts. Breeding farms should target to have an annual replacement rate lower than 50% [16]. In 2012, the average annual replacement rate was 45% [17]. This mean that around 900 gilts are needed per year to replace culled sows in a 2000 sow unit. Usually sows are culled due to low reproductive performance, lameness, or because they were not bred after weaning.
\nReplacement gilts are selected based on their growth rate, body composition, and their mother’s reproductive success [17]. In general, gilts selected as replacement are moved from the growing facility to the gilt development unit (GDU) within the breeding farm when they are around 150 days old. To accelerate the onset of puberty, gilts in the GDU are often exposed to live boars. Gilts can have direct contact with a boar or indirect contact through pen fencing. Usually, groups of vasectomized boars are introduced into gilt’s home pen for at least 20 min per day. Boar should not be housed in the GDU unit since gilts will be habituated the boar olfactory, visual, tactile, and auditory stimuli and this could decrease effective heat detection by farm workers [17].
\nWhen boars are introduced into the gilt pen, farm personnel will check gilts for estrus behavior and vulva changes described above. Daily boar exposure will induce estrus in most gilt within 10–20 days [17]. Gilts in heat are then moved to breeding stalls so they can habituate to the new environment and are breed in their second estrus. The term heat-no service (HNS) is commonly used to identify gilts that had their first estrus but were not breed. At the time of first service gilts should weight 135–150 kg and have a back fat of 12–18 mm [16, 17]. After 23 days of boar exposure, gilts that have shown no sign of estrus, can be hormonally treated to induce estrus by use of PG600. Gilts that did not come into heat after 28 days of boar exposure are usually culled from the breeding herd [16]. Gilts can be treated with Altrenogest to synchronize their estrus cycles.
\nThe effect of boar exposure on gilts and sow reproduction has been extensively study across the years. Direct contact with the boar significantly reduces puberty onset in gilts [18, 19, 20, 21, 22] and reduce sows weaning to estrus interval. The boar provides sows and gilts with olfactory, tactile, visual, and auditory stimuli that together create a maximum response. Below we discuss the effect of each individual boar stimuli on sow and gilt reproduction.
\nPigs have well developed olfactory, tactile, auditory and visual systems. Most of the work on the pig focuses on the pig olfactory sense. Pigs have been used in biomedical research to study the auditory system. The auditory and somatosensory (touch) parts of the brain have been mapped in the pig [23]. The pig auditory system is understudied. In one paper where the auditory, visual and somatosensory regions were mapped in pig reared indoors or outdoors, the authors showed different neuron structures in the outdoor pig in both auditory, visual and somatosensory regions [24]. The auditory neocortex was especially different with diverse housing systems.
\nSurprisingly few recent studies have been done on the pig visual system. Dudley Klopfer was a psychologist at Washington State University in the 1950s to about 1980. He studied the pig visual system using operant conditioning methods. He found that pigs could see colors. His work was published in a detailed proceedings paper in 1966 [25]. Ewbank [26] and his group put black contact lenses on pigs which made them temporarily blind. Pigs that could not see, had normal fights and formed a dominance hierarchy. In the world, pig do not need their sight to function, even though their eyesight is about the same as humans.
\nWhat we can conclude from the limited work on pig senses is that their olfactory system is much more developed than humans (see below) and their auditory, visual and somatosensory systems are at least as developed as humans.
\nMeese and Baldwin [27] removed the olfactory bulbs in pigs and this did not change their establishment of a dominance order. When pairs of pigs were tested, they fought the same with or without their olfactory bulbs. However, when the group size increased to 3 or 4 pigs, the bulbectomized pigs were at a disadvantage. For reproduction, removal of the olfactory system had large negative effects on reproduction [28].
\nThe boar olfactory stimulus has been widely studied of known mammalian pheromones. During the 1960s, androstenol (5alpha-Androst-16-en-3alpha-ol) and androstenone (5alpha-Androst-16-en-3-one), two steroids secreted by boars’ submaxillary salivary glands, were thought to be the boar pheromone. Multiple studies have found that these two steroids have a major role on gilts puberty onset. For instance, puberty age was significantly greater for gilts with their olfactory system inhibited by chemical or mechanical means [29, 30] and for gilts exposed to a sialectomized boar [31]. It is thought that direct contact between boar and sow is necessary to transfer the boar pheromone from boar saliva to the female snout [30]. Although these two steroids are responsible for a significant part of the boar effect on puberty onset, when applied as an individual olfactory stimulus, they were not as effective as the boar [18, 21]. Thus, it was suggested that boar saliva must contain additional analytes that together with androstenol and androstenone are acting as a multicomponent primer pheromone or that other boar stimuli are necessary for the boar pheromone to have a full effect. Recently, it was found that, quinoline was another boar specific salivary molecule (Figure 4) [5, 32]. The mixture of androstenone, androstenol, and quinoline induced more sexual behaviors in weaned sows than the mixture of androstenone and androstenol [5]. This finding might explain the lack of response of sows and prepubertal gilts when exposed to androstenone and androstenol alone.
\nSow sexual behavioral response to Androstenone (An), Androstenol (AL) and Quinoline (Q) alone or in combination. Note that androstenone increased estrus sow sexual behavior by 13.5% while all three molecules increased sow sexual behavior by over 63%. The N for this study was 947 sows [
Boars, being a non-discriminating breeder, will investigate sows independent if they are in estrus or not but sows will only be interested in a boar when they are in estrus. When sows are in Proestrus, they will seek a boar. This seeking behavior intensifies when sows are fully in estrus.
\nEarly works showed that sows would only seek the boar when they are in estrus [33] and that the boar could not detect a sow in estrus. This turned out to be only partially correct. Boars can learn the smell of an estrus sow. It was reported that the boar could not tell an estrus sow from a non-estrus sow [32, 34]. Some boars were found to be able to find an estrus sow while others could not [32, 34]. This could be a learned behavior, or some boars may have better olfactory acuity than other boars. This remains to be determined.
\nSignoret’s classic early research [4] (Table 3) on boar induction of sow sexual behavior is often cited in textbooks and seminars. In his work, he found that the boar odor was the best single stimulus to induce sexual behaviors in estrus sows. He applied back pressure to estrus sows with no odor stimulation and found that 59% of the sows showed standing reflex. If farms found only 59% of the sows that are in heat, they would not be profitable. The goal is to find 100% of the sows in estrus. With a live boar across a fence, Signoret found that 97% of the sows were detected in estrus. Further, he found that 81% of sows were detected in estrus when they were moved and heat checked in a pen containing the boar odor. This is better than 59%, but not as good as the live boar. Later, when Androstenone was used, Melrose [35] found 78% of the sows in heat—similar to Signoret’s finding with the boar odor. Scientists and producers thought at that time that Androstenone was the boar pheromone. However, why would the fence line contact be better than the odor of the boar or Androstenone alone? This is because more than Androstenone (e.g., other molecules) is needed to induce sexual behavior in the sow (see details below).
\nSource | \nOdor source | \nSows showing estrus | \n
---|---|---|
Signoret, 1975 [4] | \nNo boar odor | \n59% | \n
Boar odor in pen | \n81% | \n|
Fence-line contact with live boar | \n97% | \n|
Melrose [35] | \nAndrostenone | \n78%*\n | \n
Early research on sensory system impacts on sows showing estrus.
Note that Androstenone (*) was not as effective as fence-line contact with a boar.
The pig is a species with one of the highest numbers of functional olfactory genes [36]. To understand pig pheromone biology, one must understand the different olfactory organs of the pig. Only two of the five olfactory organs described in mammals have been described in the pig. Figure 5. Shows the five olfactory organs described in rats. Of these five organs, only the main olfactory epithelium (MOE) and the vomeronasal organ (VNO) have been described in the pig (Figure 6). The Grueneberg ganglion (GG) is the sensory organ that senses alarm pheromones in mice. Scientist believe that pigs may also have alarm pheromones [39], but they have not been isolated, nor has the GG been found in the pig. Little is known about the septal organ (SO) or the chemical sensory cells of the Trigeminal Nerve in the pig (or in other species). We do believe that the MOE receives molecules in an aerosol, while the VNO receives molecules in liquid form. The GG and SO may also need an aerosol because they are in the nasal airway where aerosols pass as the animal breathers or sniffs.
\nChemosensory epithelia in the rat nose. GG, Grueneberg ganglion; MOE, main olfactory epithelium; SO, septal organ of Masera; TG, trigeminal system/nerve; NPal, nasopalatine duct; NPhyr, nasopharyngeal duct. Arrows represent the direction of air flow. From Dauner et al. [
Ignacio Salazar pictures of the pig VNO (right) and the main olfactory bulb (left) with the AOB shown. VNO pictures are from Salazar et al. [
In addition to the olfactory organs, the nasal mucosa contains several olfactory binding proteins (OBPs). Patricia Nagnan-Le Meillour [40] has done the most recent work in pig’s OBPs. When the nasal epithelium receives a chemical signal, that signal can bind an olfactory receptor directly, or more commonly for bioactive chemicals, it binds an OBP and it is the OBP odorant complex that activates the olfactory receptors. It is likely that, before pheromone exposure, a small amount of OBPs are present in the olfactory epithelium mucosa. Pheromone exposure increases OBPs synthesis. Thus, we speculate that a second pheromone exposure 30
In Figure 6, we show excellent anatomical histological pictures of the pig MOE and the VNO by Salazar [38] (personal communication). He and his laboratory they showed that the MOE and VNO are fully present at birth in piglets.
\nThe VNO is thought to be the olfactory organ in which pheromones are perceived. But we know now that this is not always the case. One of the boar sexual pheromone molecules is sensed by the MOE [41]. The other three molecules may be sensed by the VNO or the MOE or any of the other olfactory organs not yet described in the pig. Our behavioral observations of the sow when she experiences a liquid containing a pheromone show that they chomp (see Table 1). We believe this behavior is analog to the flehmen behavior in other animals and that, by doing this, sows expose the VNO as well as the MOE to the pheromone.
\nThe VNO receives chemical signals from liquids. Some mammals (except humans and some primates) show flehmen (lip curl) behavior when they are drawing liquid chemical signals into the VNO. An example is when the bull licks cow urine and draws it into the VNO. It is likely that more than one olfactory organ is needed to sense complex pheromones that are mixtures of molecules (like the boar pheromone). The pig is not well-known to show Flehman, but they may Flehman when they receive a chemical signal in liquid form.
\nThe field of sexual behavior and pheromonal modulation of sexual behaviors have unique terminology. Table 4 provides definitions of key terms used in pheromone biology in its widest sense. This may help the reader navigate this area. The broadest term is Semiochemical in which all chemical communication falls. Sexual pheromones are species specific (the cattle sex pheromone is different than the pig sex pheromone). Certainly, the pig uses chemical communication within and between species, for example, when a pig finds a buried truffle or when a plant drives away insects—these between-species forms of chemical communication are not discussed here. We are mostly concerned with the species-specific boar pheromone that stimulates sow reproductive behavior and performance.
\nWord | \nDefinition | \n
---|---|
Pheromone | \n\n
| \n
Kairomone | \n\n
| \n
Allomone | \n\n
| \n
Synomone | \n\n
| \n
Interomone | \n\n
| \n
Semiochemical | \n\n
| \n
Definitions of common words in mammalian olfactory communication.
The pheromone concept was first described in insects by Karlson and Luscher in 1959 [42] and at the time, they were primarily referring to insect pheromones. Certainly, semiochemicals are found in most plants and animals. Pheromones were previously referred to as ectohormones. This means a hormone that works outside the animal. But pheromones do not meet the definition of a hormone, although the definitions are similar. Karlson and Luscher [42] used the term pheromone to describe a species-specific molecule that is secreted or excreted from one animal that changes the physiology or behavior of another animal of the same species. The concept was adopted rapidly among invertebrate and vertebrate animal scientists.
\nMost of the work on mammalian pheromones has been done with rodents. The pig has a highly developed olfactory system (see above), but little work has been done recently on pig pheromones including sexual pheromones. We can learn from work on other species so that we can predict possible pheromones and pheromone effects in the highly-olfactory domestic pig.
\nAn early concept was the bifurcation between priming and releasing pheromones. This dichotomy will be familiar to people who work in pig breeding with gilts and sows. The gilt develops from pre-puberty to post-puberty at around 120–200 days of age. A pheromone that stimulates the onset of puberty, for example, would be a priming pheromone. Boars certainly cause gilts to have an earlier onset of puberty (see Boar effect above). The molecule(s) that are responsible for priming gilts have not been described, but are likely to be the same as the boar pheromone. Most people might believe at this time that the boar sexual pheromone that causes sexual behavior and stimulates gilt puberty are likely to be the same molecules.
\nA releasing pheromone is one or more molecules that cause a rapid onset of behavior; sexual behavior in this case. Another releasing pheromone might be one that causes pigs to eat, or piglets to nurse, or pigs to fight, or pigs to stop fighting [39, 51]. None of these releasing pheromone molecule(s), other than the boar pheromone have been described.
\nWhat can we learn from other mammalian sexual pheromones? Given that the pig has so many functional receptors, it is likely that if a type of pheromone was described in another mammal that the pig would have a pheromone with a similar effect. Here we summarize the classic reproductive pheromones. Note that each early reproductive pheromone was named after the scientist who first reported the effect.
\nHilda Bruce described what has been called the Bruce effect in 1959 [52]—before the concept of pheromone was established. She showed that when a pregnant mouse was exposed to an adult male, preferably a dominant male, that the pregnant mouse lost her pregnancy. The Bruce effect has been replicated by many investigators and what we know is that each male has a specific major histocompability complex (MHC) class 1 protein that is secreted in its urine. The father of the mouse litter has a given MHC protein. If a new male enters the cage with a different MHC protein, the female is likely to lose her pregnancy (not 100% of the time, but at a significant rate). The male MHC protein binds the VNO in the female mice. It makes one wonder if heat checking with a boar during pregnancy might contribute to a lower farrowing rate.
\nThe Bruce effect has not been clearly documented in the pig. Assuming the Bruce effect is found in pigs, one would change the management of the sow herd. On most farms, pregnant sows experience a live, often dominant, boar walking the aisle to see if any bred sows are now in heat (meaning their pregnancy has failed). That live boar would not have the same MHC as the father of the litter because they are commonly bred by artificial insemination. We know that a small (5–10%) percentage of sows lose their pregnancy from breeding until farrowing. Part of this effect could be due to the Bruce effect. To manage this situation, pregnant sows should never experience a live boar that is not the father of her litter or perhaps is not the boar present during breeding. Keeping in mind that the Bruce effect is mediated by MHC proteins and not the boar pheromone, one can use the boar pheromone to check for return to estrus in pregnant sows without inducing the Bruce effect.
\nJohn Vandenbergh first described this pheromone in a paper published in 1975 [53]. He showed that female mice have an accelerated onset of puberty when exposed to an adult male mouse or urine from an adult male mouse. The molecule was thought to be a protein, but the actual molecule had not been described.
\nPigs clearly show the Vandenberg effect. Gilts will have a delayed onset of puberty if they do not experience an adult boar. With boar exposure, the onset of puberty is accelerated in gilts [54]. The pheromone molecule(s) that are responsible have not been described. One might predict that the boar pheromone that stimulates sow reproductive behavior and performance [5], is the same pheromone that stimulates the accelerated onset of puberty in gilts. However, if these boar pheromone molecules are responsible for the Vandenberg effect in gilts, then the dose and number of applications required to cause the Effect have not yet been determined.
\nWhitten described the Whitten Effect in a number of papers from 1956, 1957 and 1966 and 1968 [55, 56, 57, 58]. The Whitten Effect states that in a group of post-pubertal females, the presence of either other cycling adult males will cause the females to synchronize their estrus (or menstrual) cycles. Likewise, adult females tend to synchronize their cycles over time when they are housed together. The Whitten Effect has no valuable application in modern pork production at this time that we can think of; however, production systems change over time and there could be an application in the future. The Whitten Effect takes weeks or months to have its effect. Therefore, we do believe that when gilts approaching puberty are exposed to a boar, that the number or percentage that come into estrus is not evenly distributed over the 21-day cycle, so this may be happening. Boar exposure may partially synchronize a group of gilts first estrus.
\nBoars are found on most modern pig farms. They are needed to find sows in estrus when AI is used. Below are reasons to not have boars on the farm. The reasons include cost, safety and disease control.
\nThe boar costs money to buy and they cost money to maintain. Besides the direct cost of the boar, the boar does not live a good life. They are heat checking sows often and rarely if ever breed. They are often housed in a crate or stall individually for their own safety and the safety of other sows and boars.
\nBoars are dangerous to have on farms. One large farm in the USA reported that they budget $500,000 per year for boar-induced human injuries. The boar can take a single swipe at a person and damage the person severely. If a boar was very aggressive, they could do great damage to a person. While rare, boars sometimes step on people, or bite people or knock them down if a person stands in the way of the boar and his intended direction.
\nBoars carry disease. While sows move from breeding to gestation to farrowing and back to breeding, the boar resides in the barn for a long time (a year or more). The boar can be a reservoir of disease and continually infect new breeding sows.
\nWhen a serious disease (foot and mouth, ASF, etc.) is found in a country, they often limit movement of adults in some or all regions. If the farm cannot get live adult boars, and have no access to pheromones, the breeding rates will be very low.
\nMelrose [35] first suggested Androstenone was the boar pheromone. But we and others have observed that this single molecule was not sufficient to elicit the full sexual behavioral response in estrus sows. This led to the project to seek and discover the complete boar pheromone. This was accomplished by using advanced GC-MS technology to identify three unique molecules that are found in boar saliva and not found in sow saliva [59]. If one examines Figure 4, is clear that androstenone alone has only a small effect on sows expressing estrus when they are in fact in heat. But the three molecules together give the largest increase in sow sexual behavior. Furthermore, data we collected recently showed that most sows identified in estrus by a boar, also express estrus behavior to the three-molecule pheromone called BOARBETTER® (BB).
\nBoar Better (BB) was formulated to include all three molecules in an analog to the natural pheromone. When BB was applied to 12 USA farms in different USA states on nearly 4000 sows, it was discovered that BB increased Farrowing Rate, and litter size born (total or alive). Together, the increase per batch of pigs was significant—over 8% more pigs born per batch. The effect on early parities (1–3) was greater than for older sows that may have maximized their uterine capacity (Table 5). Note that while the overall increase in total pig born per litter was 0.40 more pigs with BB, in parities 1–3, the increase was 0.88 pigs/litter due to BB. This is a remarkable improvement in reproduction that cannot be achieved by any common animal health product on the market.
\nParities | \nTotal born/litter | \nBorn alive/litter | \n
---|---|---|
1–3 | \n0.88* | \n0.73* | \n
4–6 | \n−0.10 | \n−0.23 | \n
Overall | \n0.40* | \n0.22* | \n
Results from McGlone et al. showing that BOARBETTER® caused an increase in pigs born and born alive in parities 1–3 on 12 farms.
Difference in measures. LSMEANS within a row that differ (
While we believe and hope that BB is also the priming pheromone that accelerated gilt puberty, we do not have solid data to show that this is the case. These studies are underway now. We know cycling gilts can be bred with BB because it is a powerful releasing pheromone. Still, because the live boar can stimulate the onset of puberty, it is likely that BB is also the priming pheromone.
\nThis area of research is ripe for new discoveries. We know that the pig has a highly developed sense of smell. And we know that pheromones are a major player in the modulation of sexual and other behaviors. The sow releasing pheromone has been discovered and it contains three boar-unique molecules. The primer pheromone that brings gilts into heat has not been identified. It seems likely that the priming pheromone is the same set of molecules that comprise the releasing pheromone. But this must be confirmed through experimentation and practical applications.
\nWe also demonstrate that the novel boar pheromone that was recently discovered induces both sexual behavior in estrus sows and it increases the change of reproductive success in sows. This pheromone is the only known molecule to cause the full effect in behavior and reproduction.
\nWe do not know anything about three olfactory organs that are described in mice, but not yet described in the pig (SO, GG, Trigeminal nerve). Locating these in the pig and documenting how they modulate behavior will be important in the future.
\nThis chapter was written to first give the reader a background on boar and sow reproduction, olfaction and pheromones. If one wants to delve deeper in this subject, understanding the biology of the pig is helpful.
\nMeasures of reproductive success on commercial farms show that swine reproduction can be improved on commercial farms by use of a synthetic analog of the natural boar pheromone. Breeding rates should be more successful with the full understanding of the sow’s behavior before, during and after her estrous cycle both in housing facilities and free roaming herds. As well as, the different stages of estrous to properly recognize the different measurements for signs of a sow in estrus. The anatomy of the animal also plays a critical role for the pheromones to initiate her “standing reflex” through the different olfactory organs, which help determine if she is in estrus or not. The key point of this is remembering to look for the signs that are visible to show that the sow may be in heat; unreliable indicators are pricked ears, low, deep grunts, vulva temperature and color. The most important sign of estrus is when the sow shows, the standing reflex or locked up behavior. Locked up is the only behavior that indicates estrus in all sows (except those anestrus). Ultimately, the ability to properly detect sows in heat with or without a boar will save time, labor and money. With the assistance of the product BB (which contains three molecules: Androstenone, Androstanol, and Quinoline), stockpeople may be able to attain improved reproductive performance.
\nThe research discussed here (published and not published from this laboratory) was conducted at Texas Tech University and was funded by the university and by Animal Biotech. Many other studies are also presented and we thank those authors for their valuable contributions.
\nOnly the first author (JJM) declares a conflict of interest. He is the inventor on the patent on Boar Better which Texas Tech University has licensed to Animal Biotech (of which he is a minority owner). All other authors do not declare any conflict of interest.
All publications on this website are published under the Open Access model, without any subscription, registration, or access fees required from the user or his/her institution. In accordance with the Budapest Open Access Initiative's (BOAI) definition of Open Access, users are allowed to read, download, copy, distribute, print, search, and link to the full text versions of all Chapters. To read more about our Open Access Statement click here.
\n\nFor Editorial Policies for journals please consult individual journal pages.
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\\n\\n\\n\\nThe Internet has changed the dynamics of scholarly communication and publishing which is why we find it necessary to clearly indicate our stance on what we consider to be a published scientific work. A significant number of working papers, early drafts, and similar works in progress are shared openly online between members of the scientific community. It has become common practice for researchers to announce their work on a personal website or a blog in order to gather comments and suggestions from other researchers. Such works and online postings are ‘published’ in the sense that they are made publicly available, but this does not mean that if submitted for publication by IntechOpen they are not original works. We differentiate between reviewed and non-reviewed works when determining whether a work is original and has been published in a scholarly sense or not.
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All published Book Chapters are licensed under a Creative Commons Attribution 3.0 Unported License. Monographs are licensed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license granted to all others. Our Copyright Policy aims to guarantee that original material is published while at the same time giving significant freedom to our Authors. IntechOpen upholds a flexible Copyright Policy meaning that there is no copyright transfer to the publisher and Authors hold exclusive copyright to their work.
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\n\nIf there are supplemental materials to the chapter, these will be published at the time the final book is published online.
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by",editors:[{id:"204651",title:"Dr.",name:"Nieves",middleName:null,surname:"Saiz-Sapena",slug:"nieves-saiz-sapena",fullName:"Nieves Saiz-Sapena"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9790",title:"Surgical Management of Head and Neck Pathologies",subtitle:null,isOpenForSubmission:!1,hash:"8ae195fe1164fd55b69b775d596f1e8a",slug:"surgical-management-of-head-and-neck-pathologies",bookSignature:"Ho-Hyun (Brian) Sun",coverURL:"https://cdn.intechopen.com/books/images_new/9790.jpg",editedByType:"Edited by",editors:[{id:"184302",title:"Dr.",name:"H. Brian",middleName:null,surname:"Sun",slug:"h.-brian-sun",fullName:"H. Brian Sun"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9801",title:"A Comprehensive Review of Compartment Syndrome",subtitle:null,isOpenForSubmission:!1,hash:"ba676e67fb29de60aee9048ff13bf479",slug:"a-comprehensive-review-of-compartment-syndrome",bookSignature:"Saqeb Beig Mirza and Khaled Elawady",coverURL:"https://cdn.intechopen.com/books/images_new/9801.jpg",editedByType:"Edited by",editors:[{id:"99767",title:"Dr.",name:"Saqeb Beig",middleName:null,surname:"Mirza",slug:"saqeb-beig-mirza",fullName:"Saqeb Beig Mirza"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10352",title:"Abdominal Surgery",subtitle:"A Brief Overview",isOpenForSubmission:!1,hash:"0d1d92b2286b03cf2fd8d88368d9d9cb",slug:"abdominal-surgery-a-brief-overview",bookSignature:"Ahmad Zaghal and Arwa El Rifai",coverURL:"https://cdn.intechopen.com/books/images_new/10352.jpg",editedByType:"Edited by",editors:[{id:"240621",title:"Dr.",name:"Ahmad",middleName:null,surname:"Zaghal",slug:"ahmad-zaghal",fullName:"Ahmad Zaghal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:140,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"26862",doi:"10.5772/27413",title:"Titanium as a Biomaterial for Implants",slug:"titanium-as-a-biomaterial-for-implants",totalDownloads:16232,totalCrossrefCites:50,totalDimensionsCites:123,abstract:null,book:{id:"938",slug:"recent-advances-in-arthroplasty",title:"Recent Advances in Arthroplasty",fullTitle:"Recent Advances in Arthroplasty"},signatures:"Carlos Oldani and Alejandro Dominguez",authors:[{id:"70012",title:"Dr.",name:"Carlos",middleName:null,surname:"Oldani",slug:"carlos-oldani",fullName:"Carlos Oldani"},{id:"73445",title:"MSc.",name:"Alejandro",middleName:"Anibal",surname:"Dominguez",slug:"alejandro-dominguez",fullName:"Alejandro Dominguez"}]},{id:"58199",doi:"10.5772/intechopen.71963",title:"Virtual and Augmented Reality in Medical Education",slug:"virtual-and-augmented-reality-in-medical-education",totalDownloads:3059,totalCrossrefCites:21,totalDimensionsCites:41,abstract:"Virtual reality (VR) and augmented reality (AR) are two contemporary simulation models that are currently upgrading medical education. VR provides a 3D and dynamic view of structures and the ability of the user to interact with them. The recent technological advances in haptics, display systems, and motion detection allow the user to have a realistic and interactive experience, enabling VR to be ideal for training in hands-on procedures. Consequently, surgical and other interventional procedures are the main fields of application of VR. AR provides the ability of projecting virtual information and structures over physical objects, thus enhancing or altering the real environment. The integration of AR applications in the understanding of anatomical structures and physiological mechanisms seems to be beneficial. Studies have tried to demonstrate the validity and educational effect of many VR and AR applications, in many different areas, employed via various hardware platforms. Some of them even propose a curriculum that integrates these methods. This chapter provides a brief history of VR and AR in medicine, as well as the principles and standards of their function. Finally, the studies that show the effect of the implementation of these methods in different fields of medical training are summarized and presented.",book:{id:"6211",slug:"medical-and-surgical-education-past-present-and-future",title:"Medical and Surgical Education",fullTitle:"Medical and Surgical Education - Past, Present and Future"},signatures:"Panteleimon Pantelidis, Angeliki Chorti, Ioanna Papagiouvanni,\nGeorgios Paparoidamis, Christos Drosos, Thrasyvoulos\nPanagiotakopoulos, Georgios Lales and Michail Sideris",authors:[{id:"211650",title:"M.D.",name:"Panteleimon",middleName:null,surname:"Pantelidis",slug:"panteleimon-pantelidis",fullName:"Panteleimon Pantelidis"},{id:"211654",title:"Ms.",name:"Angeliki",middleName:null,surname:"Chorti",slug:"angeliki-chorti",fullName:"Angeliki Chorti"},{id:"220557",title:"Ms.",name:"Ioanna",middleName:null,surname:"Papagiouvanni",slug:"ioanna-papagiouvanni",fullName:"Ioanna Papagiouvanni"},{id:"220558",title:"Mr.",name:"Georgios",middleName:null,surname:"Paparoidamis",slug:"georgios-paparoidamis",fullName:"Georgios Paparoidamis"},{id:"220559",title:"Mr.",name:"Georgios",middleName:null,surname:"Lales",slug:"georgios-lales",fullName:"Georgios Lales"},{id:"220560",title:"Mr.",name:"Thrasyvoulos",middleName:null,surname:"Panagiotakopoulos",slug:"thrasyvoulos-panagiotakopoulos",fullName:"Thrasyvoulos Panagiotakopoulos"},{id:"220561",title:"Mr.",name:"Christos",middleName:null,surname:"Drosos",slug:"christos-drosos",fullName:"Christos Drosos"},{id:"220562",title:"Dr.",name:"Michail",middleName:null,surname:"Sideris",slug:"michail-sideris",fullName:"Michail Sideris"}]},{id:"50915",doi:"10.5772/63266",title:"Doped Bioactive Glass Materials in Bone Regeneration",slug:"doped-bioactive-glass-materials-in-bone-regeneration",totalDownloads:3462,totalCrossrefCites:13,totalDimensionsCites:33,abstract:"In the arena of orthopaedic surgery, autograft is considered to be the gold standard for correction of fracture repair or other bone pathologies. But, it has some limitations such as donor site morbidity and shortage of supply, which evolved the use of allograft that also has some disadvantages such as immunogenic response to the host, low osteogenicity as well as possibilities of disease transmission. Despite the benefits of autografts and allografts, the limitations of each have necessitated the pursuit of alternatives biomaterials that has the ability to initiate osteogenesis, and the graft should closely mimic the natural bone along with regeneration of fibroblasts. A variety of artificial materials such as demineralised bone matrix, coralline hydroxyapatite and calcium phosphate-based ceramics such as hydroxyapatite (HA), β-tricalcium phosphate (β-TCP) and bioactive glass have been used over the decades to fill bone defects almost without associated soft tissue development. Most of them were having only the properties of osteointegration and osteoconduction. Only bioactive glass possesses osteogenic property that stimulates proliferation and differentiation of osteoprogenitor cells and in some cases influencing the fibroblastic properties. But, this material has also some disadvantages such as short-term and low mechanical strength along with decreased fracture resistance; but, this was further minimised by ion doping that positively enhanced new bone formation. There are many metal ions such as magnesium (Mg), strontium (Sr), manganese (Mn), iron (Fe), zinc (Zn), silver (Ag) and some rare earths that have been doped successfully into bioactive glass to enhance their mechanical and biological properties. In some of the cases, mesoporous bioactive glass materials with or without such doping have also been employed (with homogeneous distribution of pores in the size ranging between 2 and 50 nm). These biomaterials can be served as scaffold for bone regeneration with adequate mechanical properties to restore bone defects and facilitate healing process by regeneration of soft tissues as well. This chapter encompasses the use of bioactive glass in bulk and mesoporous form with doped therapeutic ions, their role in bone tissue regeneration, use as delivery of growth factors as well as coating material for orthopaedic implants.",book:{id:"5164",slug:"advanced-techniques-in-bone-regeneration",title:"Advanced Techniques in Bone Regeneration",fullTitle:"Advanced Techniques in Bone Regeneration"},signatures:"Samit Kumar Nandi, Arnab Mahato, Biswanath Kundu and Prasenjit\nMukherjee",authors:[{id:"60514",title:"Dr.",name:"Samit",middleName:null,surname:"Nandi",slug:"samit-nandi",fullName:"Samit Nandi"}]},{id:"37120",doi:"10.5772/29607",title:"Trigeminocardiac Reflex in Neurosurgery - Current Knowledge and Prospects",slug:"the-trigeminocardiac-reflex-in-neurosurgery-current-knowledge-and-prospects",totalDownloads:3416,totalCrossrefCites:10,totalDimensionsCites:27,abstract:null,book:{id:"749",slug:"explicative-cases-of-controversial-issues-in-neurosurgery",title:"Explicative Cases of Controversial Issues in Neurosurgery",fullTitle:"Explicative Cases of Controversial Issues in Neurosurgery"},signatures:"Amr Abdulazim, Martin N. Stienen, Pooyan Sadr-Eshkevari, Nora Prochnow, Nora Sandu, Benham Bohluli and Bernhard Schaller",authors:[{id:"78171",title:"Prof.",name:"Bernhard",middleName:null,surname:"Schaller",slug:"bernhard-schaller",fullName:"Bernhard Schaller"},{id:"78525",title:"Mr.",name:"Amr",middleName:null,surname:"Abdulazim",slug:"amr-abdulazim",fullName:"Amr Abdulazim"},{id:"78530",title:"Dr",name:"Pooyan",middleName:null,surname:"Sadr-Eshkevari",slug:"pooyan-sadr-eshkevari",fullName:"Pooyan Sadr-Eshkevari"},{id:"126039",title:"Dr.",name:"Martin",middleName:"Nikolaus",surname:"Stienen",slug:"martin-stienen",fullName:"Martin Stienen"},{id:"126040",title:"Dr.",name:"Nora",middleName:null,surname:"Prochnow",slug:"nora-prochnow",fullName:"Nora Prochnow"},{id:"126041",title:"Dr.",name:"Benham",middleName:null,surname:"Bohluli",slug:"benham-bohluli",fullName:"Benham Bohluli"}]},{id:"26863",doi:"10.5772/26362",title:"The Bearing Surfaces in Total Hip Arthroplasty – Options, Material Characteristics and Selection",slug:"the-bearing-surfaces-in-total-hip-arthroplasty-options-material-characteristics-and-selection",totalDownloads:9437,totalCrossrefCites:10,totalDimensionsCites:21,abstract:null,book:{id:"938",slug:"recent-advances-in-arthroplasty",title:"Recent Advances in Arthroplasty",fullTitle:"Recent Advances in Arthroplasty"},signatures:"Hamid Reza Seyyed Hosseinzadeh, Alireza Eajazi and Ali Sina Shahi",authors:[{id:"66361",title:"Dr.",name:"Alireza",middleName:null,surname:"Eajazi",slug:"alireza-eajazi",fullName:"Alireza Eajazi"},{id:"74857",title:"Dr.",name:"Hamid Reza",middleName:null,surname:"Seyyed Hosseinzadeh",slug:"hamid-reza-seyyed-hosseinzadeh",fullName:"Hamid Reza Seyyed Hosseinzadeh"},{id:"173207",title:"Dr.",name:"Alisina",middleName:null,surname:"Shahi",slug:"alisina-shahi",fullName:"Alisina Shahi"}]}],mostDownloadedChaptersLast30Days:[{id:"65467",title:"Anesthesia Management for Large-Volume Liposuction",slug:"anesthesia-management-for-large-volume-liposuction",totalDownloads:5761,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The apparent easiness with which liposuction is performed favors that patients, young surgeons, and anesthesiologists without experience in this field ignore the many events that occur during this procedure. Liposuction is a procedure to improve the body contour and not a surgery to reduce weight, although recently people who have failed in their plans to lose weight look at liposuction as a means to contour their body figure. Tumescent liposuction of large volumes requires a meticulous selection of each patient; their preoperative evaluation and perioperative management are essential to obtain the expected results. The various techniques of general anesthesia are the most recommended and should be monitored in the usual way, as well as monitoring the total doses of infiltrated local anesthetics to avoid systemic toxicity. The management of intravenous fluids is controversial, but the current trend is the restricted use of hydrosaline solutions. The most feared complications are deep vein thrombosis, pulmonary thromboembolism, fat embolism, lung edema, hypothermia, infections and even death. The adherence to the management guidelines and prophylaxis of venous thrombosis/thromboembolism is mandatory.",book:{id:"6221",slug:"anesthesia-topics-for-plastic-and-reconstructive-surgery",title:"Anesthesia Topics for Plastic and Reconstructive Surgery",fullTitle:"Anesthesia Topics for Plastic and Reconstructive Surgery"},signatures:"Sergio Granados-Tinajero, Carlos Buenrostro-Vásquez, Cecilia\nCárdenas-Maytorena and Marcela Contreras-López",authors:[{id:"273532",title:"Dr.",name:"Sergio Octavio",middleName:null,surname:"Granados Tinajero",slug:"sergio-octavio-granados-tinajero",fullName:"Sergio Octavio Granados Tinajero"}]},{id:"42855",title:"Critical Care Issues After Major Hepatic Surgery",slug:"critical-care-issues-after-major-hepatic-surgery",totalDownloads:8893,totalCrossrefCites:1,totalDimensionsCites:1,abstract:null,book:{id:"3164",slug:"hepatic-surgery",title:"Hepatic Surgery",fullTitle:"Hepatic Surgery"},signatures:"Ashok Thorat and Wei-Chen Lee",authors:[{id:"52360",title:"Prof.",name:"Wei-Chen",middleName:null,surname:"Lee",slug:"wei-chen-lee",fullName:"Wei-Chen Lee"},{id:"157213",title:"Dr.",name:"Ashok",middleName:null,surname:"Thorat",slug:"ashok-thorat",fullName:"Ashok Thorat"}]},{id:"72175",title:"Fontan Operation: A Comprehensive Review",slug:"fontan-operation-a-comprehensive-review",totalDownloads:1218,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Since the first description of the Fontan operation in the early 1970s, a number of modifications have been introduced and currently staged, total cavopulmonary connection with fenestration has become the most commonly used multistage surgery in diverting the vena caval blood flow into the lungs. The existing ventricle, whether it is left or right, is utilized to supply systemic circuit. During Stage I, palliative surgery is performed, usually at presentation in the neonatal period/early infancy, on the basis of pathophysiology of the cardiac defect. During Stage II, a bidirectional Glenn procedure is undertaken in which the superior vena caval flow is diverted into the lungs at an approximate age of 6 months. During Stage IIIA, the blood flow from the inferior vena cava (IVC) is rerouted into the pulmonary arteries, typically by an extra-cardiac conduit along with a fenestration, generally around 2 years of age. During Stage IIIB, the fenestration is closed by transcatheter methodology 6–12 months after Stage IIIA. The evolution of Fontan concepts, the indications for Fontan surgery, and the results of old and current types of Fontan operation form the focus of this review.",book:{id:"9585",slug:"advances-in-complex-valvular-disease",title:"Advances in Complex Valvular Disease",fullTitle:"Advances in Complex Valvular Disease"},signatures:"P. Syamasundar Rao",authors:[{id:"68531",title:"Dr.",name:"P. Syamasundar",middleName:null,surname:"Rao",slug:"p.-syamasundar-rao",fullName:"P. Syamasundar Rao"}]},{id:"45712",title:"Serdev Sutures® in Middle Face",slug:"serdev-sutures-in-middle-face",totalDownloads:4895,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"2989",slug:"miniinvasive-face-and-body-lifts-closed-suture-lifts-or-barbed-thread-lifts",title:"Miniinvasive Face and Body Lifts",fullTitle:"Miniinvasive Face and Body Lifts - Closed Suture Lifts or Barbed Thread Lifts"},signatures:"Nikolay Serdev",authors:[{id:"32585",title:"Dr.",name:"Nikolay",middleName:null,surname:"Serdev",slug:"nikolay-serdev",fullName:"Nikolay Serdev"}]},{id:"55812",title:"Postural Restoration: A Tri-Planar Asymmetrical Framework for Understanding, Assessing, and Treating Scoliosis and Other Spinal Dysfunctions",slug:"postural-restoration-a-tri-planar-asymmetrical-framework-for-understanding-assessing-and-treating-sc",totalDownloads:7603,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"Current medical practice does not recognize the influence of innate, physiological, human asymmetry on scoliosis and other postural disorders. Interventions meant to correct these conditions are commonly based on symmetrical models of appearance and do not take into account asymmetric organ weight distribution, asymmetries of respiratory mechanics, and dominant movement patterns that are reinforced in daily functional activities. A model of innate, human asymmetry derived from the theoretical framework of the Postural Restoration Institute® (PRI) explicitly describes the physiological, biomechanical, and respiratory components of human asymmetry. This model is important because it gives an accurate baseline for understanding predisposing factors for the development of postural disorders, which, without intervention, will likely progress to structural dysfunction. Clinical tests to evaluate tri-planar musculoskeletal relationships and function, developed by PRI, are based on this asymmetric model. These tests are valuable for assessing patient’s status in the context of human asymmetry and in guiding appropriate exercise prescription and progression. Balancing musculoskeletal asymmetry is the aim of PRI treatment. Restoration of relative balance decreases pain, restores improved alignment, and strengthens appropriate muscle function. It can also halt the progression of dysfunction and improve respiration, quality of life, and appearance. PRI’s extensive body of targeted exercise progressions are highly effective due to their basis in the tri-planar asymmetric human model.",book:{id:"5816",slug:"innovations-in-spinal-deformities-and-postural-disorders",title:"Innovations in Spinal Deformities and Postural Disorders",fullTitle:"Innovations in Spinal Deformities and Postural Disorders"},signatures:"Susan Henning, Lisa C. Mangino and Jean Massé",authors:[{id:"204825",title:"Dr.",name:"Susan",middleName:null,surname:"Henning",slug:"susan-henning",fullName:"Susan Henning"},{id:"206242",title:"Dr.",name:"Lisa C",middleName:null,surname:"Mangino",slug:"lisa-c-mangino",fullName:"Lisa C Mangino"},{id:"206245",title:"Dr.",name:"Jean",middleName:null,surname:"Massé",slug:"jean-masse",fullName:"Jean Massé"}]}],onlineFirstChaptersFilter:{topicId:"202",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81749",title:"Regional Anesthesia in Times of COVID-19",slug:"regional-anesthesia-in-times-of-covid-19",totalDownloads:12,totalDimensionsCites:0,doi:"10.5772/intechopen.104977",abstract:"The globalized coronavirus pandemic 2019 has kept us on our toes. Although confusion is widespread and there is a trend toward normalization of almost all human activities, outbreaks remain frequent. The majority of patients with COVID-19 have a trivial to moderate clinical course; a small group develops severe pneumonia and other life-threatening complications. Vaccination against this virus has contributed to better control of the pandemic, but there are no antiviral drugs that have demonstrated efficacy; therefore, the management of surgical patients confirmed or suspected of this disease is a challenge for health care workers, including the anesthesiologists, as well as the non-COVID-19 patients who at a given moment could become carriers or sick. General anesthesia produces aerosols and risks medical and technical personnel being infected, especially those who manage the airway. On the other hand, regional anesthesia has advantages over general anesthesia because the airway is not handled; however, its limited duration is the most important concern. It is reasonable that regional anesthesia occupies a preponderant place in the safe management of all patients, as long as the type of surgery allows it, the anesthesiologist has sufficient skills and patients accept the proposed technique. At this time of globalized crisis due to COVID-19, the intrapandemic anesthetic management of patients undergoing surgery continues to be a changing task, a challenge that has been solved as new data based on solid scientific evidence arise, besides the development of drugs, safer vaccines, equipment, and health prophylactic methods. There is a clear tendency to use regional anesthesia whenever this is possible.",book:{id:"10708",title:"Topics in Regional Anesthesia",coverURL:"https://cdn.intechopen.com/books/images_new/10708.jpg"},signatures:"Víctor M. Whizar-Lugo, Karen L. Iñiguez-López and Guillermo Castorena-Arellano"},{id:"80410",title:"Management of Obturator Hernia",slug:"management-of-obturator-hernia",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.102075",abstract:"The obturator hernia is a rare pelvic hernia that often presents with symptoms of bowel obstruction. Obturator hernia corresponds to 0.5–1.4% of all abdominal hernias. Entrapment of an intestinal segment within the obturator orifice, most often the ileum, less frequently Meckel’s diverticulum or omentum, can cause intestinal obstruction. The non-specific presenting symptoms make the diagnosis of this condition often unclear. Females are 6–9 times more likely than men to be subject to the pathology, mostly occurring in a multiparous, emaciated, elderly woman so it is also called “the little old lady’s hernia.” Risk factors such as chronic constipation, chronic obstructive pulmonary disease, ascites, kyphoscoliosis, and multiparty, can predispose patients to herniation. A sign of inconstant presentation may be the presence of a palpable mass or pain radiating from the inner thigh and knee—known as Howship–Romberg sign—but it could be misleading when confused with symptoms of gonarthrosis or lumbar vertebral disc pathology. CT scan of the abdomen and pelvis has been found to be the gold standard for preoperative diagnosis because of its superior sensitivity and accuracy with respect to other radiological exams. The only possible treatment for this pathology is surgery, and management depends on early diagnosis.",book:{id:"11238",title:"Hernia Surgery",coverURL:"https://cdn.intechopen.com/books/images_new/11238.jpg"},signatures:"Luigi Conti, Carmine Grassi, Filippo Banchini, Deborah Bonfili, Gaetano Maria Cattaneo, Edoardo Baldini and Patrizio Capelli"},{id:"81656",title:"Totally Extraperitoneal Approach (TEP) for Inguinal Hernia Repair",slug:"totally-extraperitoneal-approach-tep-for-inguinal-hernia-repair",totalDownloads:12,totalDimensionsCites:0,doi:"10.5772/intechopen.104638",abstract:"Laparoscopic inguinal herniorrhaphy was initially described by Ger in the early 1980s. Nowadays, two techniques are worldwide adopted: the transabdominal preperitoneal approach (TAPP) and the totally extraperitoneal approach (TEP). In these repairs, the myopectineal orifice is approached posteriorly and allows for inguinal, femoral, and obturator hernia repairs to be performed simultaneously. TEP is a relatively new technique. McKernan and Law first introduced TEP in 1993. Some proponents of TEP advocate for this technique over the transabdominal approach due to the shorter operative times, especially for bilateral hernias, and decrease the risks of vascular, bowel, and bladder injuries as well as bowel obstructions, adhesions, or fistula formation potentially associated with intraperitoneal dissection and intraperitoneal mesh exposure. When compared with open hernia repair, and in particular for recurrent (after open) and bilateral hernias, many surgeons prefer the laparoendoscopic approach due to quicker recovery times and less postoperative and chronic pain. In experienced hands, there are no absolute contraindications to TEP, although a careful decision should be made to tailor the approach to both patient and surgeon factors. In this chapter, we will describe the technical steps of totally extraperitoneal hernia repair, the potential complications, and troubleshooting when needed.",book:{id:"11238",title:"Hernia Surgery",coverURL:"https://cdn.intechopen.com/books/images_new/11238.jpg"},signatures:"Ioannis Triantafyllidis"},{id:"80570",title:"Spigelian Hernia: Clinical Features and Management",slug:"spigelian-hernia-clinical-features-and-management",totalDownloads:11,totalDimensionsCites:0,doi:"10.5772/intechopen.102809",abstract:"The Spigelian hernia is a rare variety of ventral hernia and has an incidence ranging from 0.1–2% of all abdominal wall hernias. It occurs through a well-defined defect in the Spiegel’s fascia adjacent to the semilunar line. It can be congenital or acquired. The acquired variety is predisposed by stretching and weakening of the abdominal wall by factors that increase the intraabdominal pressure. These hernias are most commonly located in the interparietal plane with no visible or palpable mass, and only 50% of cases could be diagnosed clinically before any surgical intervention. Radiological investigations like USG and CT scans confirm the clinical diagnosis or pick up the subclinical varieties that present with non-specific pain in the anterior abdominal wall. Surgery is the mainstay of management. These hernias are prone to early incarceration and strangulation and therefore should be operated at the earliest. It is stressed that a prosthetic mesh should be used for a better outcome as it decreases recurrence. Conventional open hernioplasty has been largely replaced by a laparoscopic approach such as TAPP, TEP, IPOM and robotic-assisted surgery. Early diagnosis and surgery prevent morbidity and dreaded complications.",book:{id:"11238",title:"Hernia Surgery",coverURL:"https://cdn.intechopen.com/books/images_new/11238.jpg"},signatures:"Aakansha Giri Goswami, Farhanul Huda, Sudhir Kumar Singh, Navin Kumar and Somprakas Basu"},{id:"80950",title:"Laparoscopic Hiatal Hernia Repair during in-Sleeve Gastrectomy",slug:"laparoscopic-hiatal-hernia-repair-during-in-sleeve-gastrectomy",totalDownloads:16,totalDimensionsCites:0,doi:"10.5772/intechopen.104395",abstract:"Obesity is one of the most important health problems in developed and developing countries. Morbid obesity is defined as having a body mass index (BMI) of more than 40 kg/m2. Obesity does not only predispose to gastroesophageal reflux, but is also an important independent risk factor for the development of hiatal hernia (HH). There are articles advocating about half of obese patients have a hiatal hernia. Hiatal hernia not only exacerbates reflux symptoms, but may also lead to incomplete removal of the gastric fundus during laparoscopic sleeve gastrectomy (LSG). When hiatal hernias are seen preoperatively or intraoperatively for bariatric surgery, surgical correction should ideally be made with mesh reinforcement to prevent further clinical progression.",book:{id:"11238",title:"Hernia Surgery",coverURL:"https://cdn.intechopen.com/books/images_new/11238.jpg"},signatures:"Seyfi Emir, Hasan Erdem, Mehmet Gençtürk, Muhammed Said Dalkılıç, Abdullah Şişik and Selim Sözen"},{id:"80352",title:"Anatomical and Surgical Principles of Ventral Hernia Repairs",slug:"anatomical-and-surgical-principles-of-ventral-hernia-repairs",totalDownloads:44,totalDimensionsCites:0,doi:"10.5772/intechopen.102734",abstract:"Hernias comprise a growing problem in surgical science. The most recent classification scheme for hernias emphasizes on the size of defect as well as on whether it is an incisional hernia. The latter group includes complex hernias, namely hernias that can not be managed with simple surgical techniques. This can be accomplished with retromuscular repairs or the more complex anterior and posterior component separation techniques. An anatomic repair is usually reinforced with interposition of mesh. Newest techniques, such as the use of botulinum toxin to induce temporary paralysis of the lateral abdominal wall musculature, referred to as chemical component separation, now present new tools in the restoration of anatomy-based repairs. The chapter entitled “Anatomical and surgical principles of ventral hernia repairs” aims to describe the anatomical and surgical principles of current practice regarding the repair of ventral -primary and incisional-hernias.",book:{id:"11238",title:"Hernia Surgery",coverURL:"https://cdn.intechopen.com/books/images_new/11238.jpg"},signatures:"Chrysanthi Papageorgopoulou, Konstantinos Nikolakopoulos, Fotios Efthymiou and Charalampos Seretis"}],onlineFirstChaptersTotal:22},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:99,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:288,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 24th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:50,paginationItems:[{id:"81927",title:"Purinergic System in Immune Response",doi:"10.5772/intechopen.104485",signatures:"Yerly Magnolia Useche Salvador",slug:"purinergic-system-in-immune-response",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"80495",title:"Iron in Cell Metabolism and Disease",doi:"10.5772/intechopen.101908",signatures:"Eeka Prabhakar",slug:"iron-in-cell-metabolism-and-disease",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Iron Metabolism - Iron a Double‐Edged Sword",coverURL:"https://cdn.intechopen.com/books/images_new/10842.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81799",title:"Cross Talk of Purinergic and Immune Signaling: Implication in Inflammatory and Pathogenic Diseases",doi:"10.5772/intechopen.104978",signatures:"Richa Rai",slug:"cross-talk-of-purinergic-and-immune-signaling-implication-in-inflammatory-and-pathogenic-diseases",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81764",title:"Involvement of the Purinergic System in Cell Death in Models of Retinopathies",doi:"10.5772/intechopen.103935",signatures:"Douglas Penaforte Cruz, Marinna Garcia Repossi and Lucianne Fragel Madeira",slug:"involvement-of-the-purinergic-system-in-cell-death-in-models-of-retinopathies",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}}]},overviewPagePublishedBooks:{paginationCount:27,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science and Technology from the Department of Chemistry, National University of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013. She relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the National Institute of Fundamental Studies from April 2013 to October 2016. She was a senior lecturer on a temporary basis at the Department of Food Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is currently Deputy Principal of the Australian College of Business and Technology – Kandy Campus, Sri Lanka. 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Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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