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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"496",leadTitle:null,fullTitle:"Soybean and Health",title:"Soybean and Health",subtitle:null,reviewType:"peer-reviewed",abstract:"Worldwide, soybean seed proteins represent a major source of amino acids for human and animal nutrition. Soybean seeds are an important and economical source of protein in the diet of many developed and developing countries. Soy is a complete protein, and soy-foods are rich in vitamins and minerals.\nSoybean protein provides all the essential amino acids in the amounts needed for human health.\nRecent research suggests that soy may also lower risk of prostate, colon and breast cancers as well as osteoporosis and other bone health problems, and alleviate hot flashes associated with menopause. This volume is expected to be useful for student, researchers and public who are interested in soybean.",isbn:null,printIsbn:"978-953-307-535-8",pdfIsbn:"978-953-51-5171-5",doi:"10.5772/1007",price:159,priceEur:175,priceUsd:205,slug:"soybean-and-health",numberOfPages:514,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"66d40dbc031b2825ba95f7ac2bfae1b6",bookSignature:"Hany El-Shemy",publishedDate:"September 12th 2011",coverURL:"https://cdn.intechopen.com/books/images_new/496.jpg",numberOfDownloads:140272,numberOfWosCitations:107,numberOfCrossrefCitations:40,numberOfCrossrefCitationsByBook:4,numberOfDimensionsCitations:135,numberOfDimensionsCitationsByBook:4,hasAltmetrics:1,numberOfTotalCitations:282,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 21st 2010",dateEndSecondStepPublish:"November 18th 2010",dateEndThirdStepPublish:"March 25th 2011",dateEndFourthStepPublish:"April 24th 2011",dateEndFifthStepPublish:"June 23rd 2011",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy",profilePictureURL:"https://mts.intechopen.com/storage/users/54719/images/system/54719.jpg",biography:"Prof. Hany A. El-Shemy received a Ph.D. in Biochemistry from the University of Cairo, Egypt, and a Ph.D. in Genetic Engineering from the University of Hiroshima, Japan. He holds two patents and has written thirteen international books. He has also published more than 100 SCI journal papers and 55 conference presentations. Dr. El-Shemy was a technique committee member as well as chair of many international conferences. He has also served as editor for journals including PLOS ONE, BMC Genomics, and Current Issues in Molecular Biology. He has received several awards, including state prizes from the Academy of Science, Egypt (2004, 2012, and 2018), the Young Arab Researcher prize from the Shuman Foundation, Jordan (2005), and Cairo University Prizes (2007, 2010, and 2014). He served as an expert for the African Regional Center of Technology, Dakar, Senegal, as well as a visiting professor at Pan African University, African Union. He served as vice president of the Academy of Science and Technology, Egypt, from 2013 to 2014. Since 2014 he has been the dean of the Faculty of Agriculture, Cairo University. In 2018, he was elected a fellow of the African Academy of Science.",institutionString:"Cairo University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"13",institution:{name:"Cairo University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"323",title:"Food and Nutrition",slug:"food-and-nutrition"}],chapters:[{id:"19741",title:"Soybean Products Consumption in the Prevention of Cardiovascular Diseases",doi:"10.5772/22567",slug:"soybean-products-consumption-in-the-prevention-of-cardiovascular-diseases",totalDownloads:2376,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Iván Palomo, Luis Guzmán, Elba Leiva, Verónica Mujica, Gilda Carrasco, Nora Morgado and Daniel R. 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The quality control and inspection of the high-speed printing process is a critical topic in various industries ranging from electronics to pharmaceutical products. The advent of higher quality requirements from end users and higher costs of raw materials has limited the profit margin of labeling producers. The label producers need to improve the quality of their products and improve the production efficiency by keeping the cost and management thresholds to a minimum level. Typical industrial label printing mechanisms include offset-printing, letterpress-printing, combination-printing, and flexography printing. Various challenges faced by the labels are the limited sized of text-containing region, relatively small size of labels, clear text, ink-flow control for same shades, and text alignment. Usually, the common defects encountered in the printing process are misprinting, text fading, and various shades in printed text. According to the report [1], in 2010 the Chinese pharmaceutical label market demand was more than 165 million m2, and the increase is predicted to be 10–12% in the next 3–5 years. Europe and America had a market demand of 300 million m2 and 250 million m2, respectively, and both are expected to increase by about 3% annually. It is evident that the market demand of pharmaceutical labels in western countries is higher than in China.
\nThe Chinese market is expected to witness an increase in demand in the coming years. It is also reported that in the past 3 years, the labor costs have increased dramatically and QC management has become more difficult. Manual QC inspection can be easily affected by factors such as lack of experience, emotions, human eye perception, and environmental conditions. These factors lead to an inconsistent and poor standard of inspection. Although a review process is usually added in the inspection process in order to recheck the misprinted labels and quality defects, it cannot guarantee 100% quality inspection and also leads to extra labor costs and time consumption. In order to win the customer satisfaction, the inspection QC should be improved through automation. Even tiny mistakes in the label printing can put a bad impression in the overall product quality and can reduce a good customer relationship. Therefore, automatic inspection system is an obvious choice for the industries, and it will have room to grow in the near future.
\nThe proposed scheme performs quality inspection in three steps. The first step is related to the inspection of printed text alignment with respect to the industrial object. Although the requirement for printing alignment is company specific, the proposed mechanism is adaptable and adjustable according to the specific requirement. The second step performs quality inspection based on detection of varying printing shades in the detected text. The third step is aided by supervised machine learning, and it performs the detection of misprinted text. The rest of the paper is composed as follows. Section 2 addresses the related work for computer-aided quality inspection of printing. Section 3 explains the SAML-QC algorithm. Section 4 shows the results of performing the proposed inspection on a given industrial object. Finally, Section 5 presents conclusion and future work.
\nRecently, a few researches have investigated computer-aided detection and image quality assessment. In [2] a technique based on the comparison of an inspected document with its referential version is discussed. In [3] an image quality assessment algorithm is proposed that does not rely on reference images, and its general framework emulates human quality assessment by first detecting visual components and then assessing quality against an empirical model for face detection. In the algorithm of Rowley et al. [4], a neural network is trained to detect face patterns in a region of 20-by-20 pixels. The determination of an arbitrary image such that if the square is a face region, the square is down-sampled to the size of 20 by 20 and equalized, resulting in a normalized signal.
\nA similar proposition holds for the face detector of Viola and Jones [5]. In their algorithm a feature-based classifier is trained over a square box of 24-by-24 pixels, with each feature defined by a feature template composed of a group of rectangular sub-windows. In [6], two machine learning algorithms are used for feature selection: mixture of Gaussian and radial basis function (RBF). The first one is a statistical distribution estimation-based algorithm, while the second is a function approximation-based algorithm. However, the preliminary experiment based only on face detection and face-based quality modeling yielded encouraging results. However, more work needs to be done in the areas such as object detection, feature selection, and machine learning to better establish this method.
\nAs an efficient alternative, the machine vision systems can filter out the physical limitations and subjective judgmental decisions of humans. In [7] an image processing technique for the development of a low-cost machine vision system is explored for the inspection of the pharmaceutical capsule. This work discusses the two-part gelatin capsule inspection system by using image processing techniques for border tracing and approximation of the capsule to a circle. A quality control feedback performs pass/reject decision and puts capsules to the appropriate bin. In [8] a new approach for detecting the printing accuracy based on the technology of machine vision is presented.
\nThe process consists of image acquisition, filtering, segmentation, and image matching. In this chapter, JSEG [9] algorithm is used to segment the textile printing images with obvious texture and then make a match for the segmented edge information, to obtain deviation area of the image and calculate the deviation position. However, in their experiments, several limitations are found for the system. One case is when the similar colors between the two neighbor regions cannot be segmented. The work in [10] introduced the algorithm based on wavelet packet and the regional analysis. It analyzes the significance of the threshold of binarization in defect detection combined with morphology area analysis method to extract specific features of defects and determine the type of defect. In [11] a study was conducted to evaluate how accurately a machine learning method can predict human judgment about printed pattern quality. Similarly [12] also proposed machine learning-based quality assessment scheme.
\nThe block diagram of the proposed scheme is shown in Figure 1. It shows that the algorithm receives the input image and performs pre-filtering. The pre-filtering process starts by RGB to gray scale conversion and resizing the input image to a width of 500 pixels without losing the aspect ratio. A Gaussian blur (of kernel size 9 × 11) filters the salt and pepper noise in the image. Then the histogram equalization process enhances the contrast. The next step is the initialization of structuring kernels. These kernels play a major role in the morphological closing operation. This operation combines the text-containing region and supports the detection of text-containing region for the alignment testing. The next step is the initialization of TopHat morphology [13] to find the white regions against the darker ones.
\nBlock diagram of SAML-QC algorithm.
It follows the computation of Scharr gradient [14] of the TopHat image for edge detection. The proposed scheme used the Sobel operator in horizontal axis to calculate the absolute value element-wise. The minimum and maximum values of Scharr gradient are obtained followed by scaling to the range 0–255 per pixel value. The next step performs the morphological closing operation to fill the gaps. It is followed by Otsu’s auto-thresholding [15] to binaries the image. The morphological closing and dilation process is performed to convert the text-containing region as a combined blob. It is intuitive that this combined block contains the actual area of the text and makes the image ready for the detection of contours. The purpose of finding contours in the image is to detect the text-containing region inside the given object. After that, the text-containing region is cropped and stored in a buffer for later use in stochastic assessment. The text-containing region is identified by selecting the bounding box with optimum aspect ratio in the process of iterating over the found contours. The red rectangle is displayed on the image of the selected text. The coordinates of the text-containing region are used for the testing of text alignment.
\nIn printing industry the common text alignment errors are related to the horizontal and vertical alignments. In the current paper, it is assumed that the best position of the text is right at the center of the object. Therefore, any text region that is printed too much horizontally or vertically should be identified. However, the height and width of the industrial objects and their respective printed texts are different due to the varying nature of performance of the printing labelers as discussed in [10]. Therefore, the proposed algorithm presents a mathematical formulation to detect alignment error of the text inside an industrial object. Figure 2 shows an abstract image of an industrial object (red portion) with markers showing the dimensions. The width and height of the industrial object are represented by Wo and Ho, respectively. The width and height of text-containing region are represented by w and h. Let (xo,yo) and (xt,yt) represent the top left corners for the object and text boxes, respectively, as shown in Figure 2. The absolute difference in terms of pixels between the top edge of industrial object and top of the bounding box of the text region is given by Eq. (1), and similarly, the absolute differences for down and left are given by Eqs. (2) and (3):
\nParameters for the alignment test of text-containing region.
The proposed criterion for text alignment is based on threshold value for vertical and horizontal alignments. Let UDThresh represent threshold for up-down or vertical alignment testing. The value of UDThresh is set as h. Let LThresh represent the left-right or horizontal alignment.
\nThe value of LThresh is set as Wo/4. It means that it contains the width of one-fourth of the full width of object. The decision boundaries for horizontal and vertical alignment passed or failed are given as follows. If abs{(U-D)} ≤ UDThresh, then the vertical alignment is considered as passed else it is failed. If L ≤ LThresh, then the horizontal alignment is considered as passed, else it is considered as failed.
\nAfter the assessment of alignment, the next step is to perform the optical character recognition. For this purpose the proposed scheme crops the text-containing region (
The proposed scheme used bilateral filtering [16] to improve the text regions while suppressing the background. The bilateral filtering alters the intensity value of each pixel with the weighted average of its neighbors that is Gaussian distributed. The next step is to perform the gray scale conversion and perform Otsu’s autothresholding and bit-wise logical NOT operation to obtain binary image. This image is saved as a PNG format. This PNG image is provided as input image to the state-of-the-art Tesseract open-source OCR engine v3.02 [17]. The purpose of performing OCR is to get bounding boxes and location of anything that looks like a character. As a result an html file containing the position and sizes of each detected letter is generated. Figure 3(a) and (b) shows an image that is cropped and processed by the stated procedure to get the detected boxes of letters in the text and marked with green rectangles.
\nThe detection of bounding boxes of letters: (a) text area selected; and (b) detection of letters.
The next block performs the stochastic assessment of the printing quality in terms of detection of overly faded printed text due to the imperfections in printing process as discussed in [1].
\nThe intensity value of each printed pixel can be considered as a random variable
It is quite clear that the probability density function (p.d.f) of parameter H needs to be determined in order to maximize the expression Eq. (4). It is assumed that ni is IID with
And the p.d.f of
It is known that the conditional p.d.f of H given y is in Eq. (7):
\nInserting the values from Eqs. (5) and (6) in Eq. (7) provides Eq. (8):
\nThe expression in Eq. (8) can be defined in terms of q(y) as shown in Eq. (9):
\nThe notation σ is given by Eq. (10):
\nIt should be noted that q(y) is only the function of y; therefore, the best estimate HMAP of H is the value where f(H|y) gets the highest peak, which is obtained from Eq. (11) when H = HMAP:
\nEq. (10) can be solved to get Eq. (12):
\nIf \n
HMAP is the best estimate of intensity levels of the character-containing region of a detected box, yet its value varies for every other detected box, and its probability distribution is also unknown, so it can also be assumed as a random variable that follows Gaussian distribution. If B represents the number of detected character boxes in a given image, then the set of real values hMAP(u) assigned to HMAP for all detected boxes is shown in Eq. (14), where u represents the index of each box.
\nLet E [HMAP] be the expectation of HMAP, and it is expressed as Eq. (15). The variance σ 2HMAP can be found in Eq. (16):
\nDefinition 1: (Set of bad boxes) The set of all those boxes such that members do not satisfy the conditions in Eq. (17) is called set of bad boxes.
\nHere n represents the quality index, and smaller value of n corresponds to higher demand of quality of label printing,
\nThe selection of bad box is performed by Eq. (17), as one of the main concerns in the quality inspection of label printing is to find the overly printed or faded printed characters. All the character boxes that fall under the stated condition Eq. (17) are considered as members of the set of good boxes. It is quite intuitive that high-quality printing demands larger set of good boxes. Therefore, the proposed scheme used two separated counters called GBc and BBc representing the numbers of good boxes and bad boxes, respectively. The % quality success for similar intensity levels QSI is given by Eq. (18):
\nIt should also be noted that the value of QSI has a direct relationship with quality index n. The smaller value of quality index means strict requirement of quality and for the same image QSI decreases with the decrease in value of n and vice versa.
\nIn order to plot the probability density estimate of HMAP, the procedure for kernel density estimation [20] is used. It returns a probability density estimate f for the sampled data in the vector or two-column matrix. It estimates the density at 100 points for univariate data. Figure 4 shows the plot of probability density estimate for HMAP of the image in Figure 3(a). It is clear that p.d.f approximately follows Gaussian curve with a certain value of mean and variances.
\nKernel density estimate plot of HMAP for the image in
The detection of misprinted box is challenging in terms of its probability of occurrences and detection. The OCR engine can detect it as a text although being probably wrong detected and classified. The proposed scheme achieves the detection of misprinted box by deploying supervised machine learning using k-NN. The k-NN algorithm is a nonparametric method used for the classification and regression [21] in the pattern recognition. The supervised training aggregates the human responses to the appearance of a letter inside the detected box. The purpose of this step is to provide supervised learning samples and responses for the k-NN algorithm.
\nThe supervised machine learning procedure of the proposed scheme takes input sample image of industrial object which is printed with no defects. All the characters in this sample image are alphabets from A to Z, a to z, -, and numeric digits from 0 to 9. Let us call the set of these input images as no-misprinted-images (NMI). The training process starts by iterating the NMI for all detected boxes, and for each detected box, a human response is provided as a label and aggregated to a human responses database (HRD) file, because the human needs to press the related key from the keyboard. As for each detected letter box, its ratio width/height = 2/3; therefore each box is aggregated as a matrix of 20 × 30 pixels in separate matrices received database (MRD) file.
\nTherefore, at the end of training process, two (HRD and MRD) files are ready for the k-NN algorithm. The k-NN algorithm takes these two files as input and finds the nearest neighbor in terms of its output as hamming distance D as stated above. It is quite intuitive that D will have higher value for the misprinted or unknown letters, because the training process did not consider those letters. The value of D for each printed letter can be considered as a random variable sampled from a random process at time t, and since its distribution is also unknown, therefore, it is assumed that it follows Gaussian distribution. Based on the fact stated by [22], the proposed scheme also assumes that D is IID Gaussian random variable. The next step is finding the expectation of D for each letter box. It should be noted that D is normalized by the size of box, i. e., 20 × 30. Let us represent E[D] and σD2 as the mean and variance of D. We can compute these values using the similar way as described in Eqs. (15) and (16), which provide the second order statistics for the distance. Let the set of real values d(u) assigned to the random variable D be given by Eq. (19):
\nDefinition 2: (Misprinted box detection) The set of all those boxes such that members do not satisfy the conditions Eq. (20) is called set of misprinted bad boxes.
\nAgain the quality index m represents the strict boundary for the selection of misprinted boxes. All the character boxes that fall under the stated condition Eq. (20) are considered as members of the set of good printed boxes. It is quite intuitive that high-quality printing demands larger set of good boxes. Therefore, two separated counters called GPBcount and MPBcount represent the numbers of good printed boxes and misprinted boxes, respectively. The % quality success for good printed boxes QSGPB is given by Eq. (21):
\nThe final step is the printing of the acquired results related to the text alignment, QSI and QSGPB. These results can not only draw the outcome of printing inspection process but can also provide feedback to the printing labelers to automatically adjust the process according to the type of printing errors.
\nTable 1 summarizes the values of horizontal and vertical alignments for sample image in Figure 5. The results support the human observation of central text alignment for this kind of particular object. It should also be noted that text alignment specification and parameters are user specific.
\nImages | \nU | \nL | \nD | \nUDThresh | \nLThresh | \nAlignment testing | \n|
---|---|---|---|---|---|---|---|
Horizontal | \nVertical | \n||||||
1 | \n42 | \n59 | \n50 | \n170 | \n119 | \nPassed | \nPassed | \n
Text alignment assessment results for the given image.
Text alignment detection.
Figure 6 shows the bar graph of the estimated values for the random variable HMAP for each detected text in Figure 3(b).
\nEstimated intensity values of HMAP.
Figure 7 shows the histogram of HMAP in terms of numbers of boxes and the value of random variable HMAP. It also shows the corresponding normal distribution curve fitted based on the values of HMAP.
\nPlot shows fitting a normal distribution to the values of HMAP.
Table 2 summarizes the results of printing quality assessment in order to test the intensity variations in the printed labels. It shows mean, variance, quality (Q) factor nσHMAP, the sum of good and bad boxes, and finally the QSI. It is obvious from the results that Q factor decides the value of QSI.
\nQ Index n | \nMean E [HMAP] | \nVariance σ 2HMAP | \nQ factor nσHMAP | \nBox counts GBc + BBc | \nQSI (%) | \n
---|---|---|---|---|---|
1 | \n66 | \n6 | \n2.44 | \n13 + 10 | \n56.52 | \n
2 | \n66 | \n6 | \n4.89 | \n22 + 1 | \n95.65 | \n
3 | \n66 | \n6 | \n7.35 | \n23 + 0 | \n100 | \n
Printing quality assessment results for HMAP.
The value of quality index is varied as n = 1, 2, and 3 that increases the value of GBc as 13, 22, and 23, respectively. Additionally, the values for QSI for n = 1, 2, and 3 are 56.52, 95.65, and 100%, respectively.
\nFigure 8 shows the output of SAML-QC scheme for the detection of bad printed labels. The higher quality control requires lower value of n.
\nDetection of bad printed boxes for different n: (a) n = 1, (b) n = 2, and (c) n = 3.
Figure 8(a) shows that for the restriction n = 1, all good boxes are detected and marked with green color, whereas, all the boxes in red color are the ones with value of hMAP(u) ≥ E[HMAP] + nσ2HMAP, whereas, boxes with hMAP(u) ≤ E[HMAP]—nσ2HMAP are represented by yellow boxes because they belong to the faded printing category. Similarly, Figure 8(b) and (c) shows the output images for n = 2 and 3, respectively.
\nThe next assessment is related to the detection of misprinted characters, and Figure 9 shows result of k-NN classification performed through supervised machine learning and the distance D for each detected character.
\nBar graph of k-NN classification distance D.
It is clear from the results in Figure 9 that the two higher spikes for the detected character S and 3 are located at the position of misprinted characters.
\nTable 3 shows results of the process for the detection of misprinted boxes as discussed in Section 3. It is observed that the proposed scheme put a stable restriction on the misprinted labels, and it is shown in Table 3 that the value of QSGBP remains 91.30% for all three values of m.
\nQuality index m | \nMean E [D] | \nVariance σD 2 | \nQ bound nσD | \nBox counts GPBc+MPBc | \nQSGBP % | \n
---|---|---|---|---|---|
1 | \n3397.88 | \n1.38 × 107 | \n3727.68 | \n21 + 2 | \n91.30 | \n
2 | \n3397.88 | \n1.38 × 107 | \n7455.36 | \n21 + 2 | \n91.30 | \n
3 | \n3397.88 | \n1.38 × 107 | \n11183.04 | \n21 + 2 | \n91.30 | \n
Misprinted labels’ assessment results.
Figure 10 shows the detection of misprinted labels, and they are marked with the red boxes for m = 1, 2, and 3.
\nDetection of misprinted boxes: (a) m = 1, (b) m = 2, and (c) m = 3.
This chapter proposes a stochastic assessment and machine vision-based technique to assess the printing quality of text on industrial objects. The assessment is based on three quality defects such as text misalignment, varying printing shades, and misprinted text. It is concluded from the results that second-order statistics related to the intensity values of pixels of text located under the threshold region of the original image can provide enough information to perform quality inspection. On the other hand, the hamming distance acquired by the k-NN supervised machine learning can also be taken as a random variable, and again the second-order statistics are helpful in order to detect the misprinted letter. In the future SAML-QC technique needs to be evaluated on various other images such as electronics parts and medical parts.
\nMy deepest acknowledgment is to Prof. Tao JIANG of the College of Information and Communication Engineering, Harbin Engineering University, for guidance, kind support, and wisdom.
\nTreatment of acute postoperative pain is an important part of perioperative care. Insufficient analgesia is related to adverse outcomes such as immunosuppression, hyperglycemia, aggravated early rehabilitation, deterioration in patients’ quality of life, more common postoperative complications, a longer period of recovery after surgery, and progress from acute to chronic pain [1, 2].
Ketamine, a
U.S. Food and Drug Administration indications for the usage of ketamine are adjuvant to general anesthesia, induction agent for general anesthesia, sedation for short-time procedures [6]. This means that usage of ketamine for acute postoperative pain treatment is not based on official indications, because there is a lack of researches on this topic.
In recent years, there has been considerable interest in ketamine efficiency in treating acute postoperative pain. Guidelines published in 2018 indicate that a regimen of low-dose ketamine can be described as following—ketamine bolus lower than 0.35 mg/kg, infusion—lower than 1 mg/kg/h [5]. In 2015, Jouguelet-Lacoste with colleagues published a literature review that included five meta-analyses studying intravenous ketamine impact on postoperative pain inhibition. They revealed that ketamine lowers pain points and additional opioid consumption. Four out of five researches revealed that pain scores in the first 24 hours after operation lowered 87.5, 59, 54.5, and 25% compared to placebo [7]. In 2018, Cochrane systematic review included 130 pieces of research to find if low-dose ketamine effectively alleviates acute postoperative pain. Consumption of opioids in the first 24 hours was 8 mg less and the first 48 hours 13 mg less when compared with placebo. Pain at rest lowered 5/100 mm of visual analog scale (VAS), during movement 6/100 mm VAS in the first 48 hours [8].
Unfortunately, there were no guidelines on what dosage, which patient group, and in what way ketamine should be used. In 2018, the American Society of Regional Anesthesia and Pain Medicine together with the American Academy of Pain Medicine and the American Society of Anesthesiologists published guidelines on intravenous usage of ketamine for managing acute pain. They indicated the most suitable group of patients for using ketamine, its dosage, indications, contraindications, and trials supporting this evidence. The authors of these guidelines also pointed out that more trials should be done to determine the accurate and effective doses of ketamine for effective acute pain management [6].
The design of this systematic review of the literature is followed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement guidelines. Data were identified from searches of MEDLINE (PubMed) database. The combination of keywords included terms “low” and “dose” and “ketamine” and “pain” and “postoperative” in PubMed Advanced Search Builder in all fields accordance with the PICO criteria: “Participants” were limited to 18 years and older, “interventions” covered were randomized controlled clinical trials on low-dose intravenous ketamine, “comparator”—comparing ketamine with placebo and/or a different dose of ketamine, and “outcomes” discovered after a thorough analysis of researches and classified according to the trial type and most common findings. Records were screened by the title, abstract, and full text. Inclusion criteria were as follows: (1) full-text articles published in English; (2) not older than 2011; (3) double- or triple-blinded randomized prospective trials of different ketamine intravenous dosage and/or placebo; (4) American Society of Anesthesiologists (ASA) I–III class; (5) age over 18 years; (6) VAS or Numeric Pain Scale (NPS) used for evaluation of acute postoperative pain. However, review or meta-analysis or systematic review articles, commentaries, abstract-only publications, guidelines, case reports, not randomized trials, ketamine given intramuscularly/orally/subcutaneous, ketamine given in the emergency department were excluded. The detailed search flowchart is presented in Figure 1.
Flowchart.
The research yielded 214 results, extracted from one database. All duplicates were removed, and 94 articles were checked manually for relevance by screening their titles and abstracts. About 51 results met the inclusion criteria, but only 18 were included after a full-text review. Only full-text articles were selected because the information given in the abstract was not sufficient for the thorough analysis. The randomized trials, conducted in 2011–2020 and which compared different doses of ketamine and placebo given for patients during various surgeries to investigate the effect of the drug on the management of acute postoperative pain, were analyzed. About 33 publications were excluded for reasons explained in Figure 1.
Those 18 selected trials could be divided into several groups—those who investigate ketamine bolus dose (six trials), those who investigate different infusion dose peri- and postoperation (two trials), those who investigate both only during operation (six trials), and those who investigate bolus and infusion, which is continued during and after the operation (four trials). A summary of the results of 18 analyzed studies is provided in Table 1.
Author | Year of publishing, country | Surgery type | Number of patients | Type of anesthesia | Inclusion criteria | Pain and satisfaction evaluation |
---|---|---|---|---|---|---|
Subramaniam [9] | 2011, USA | Lumbar/thoracic laminectomy | 30 | General anesthesia | Age 18 and older, ASA 1–3 class | VAS (0–10 cm) at 0, 1, 2, 4, 8, 12, 18, 24, 36, 48 h after surgery. Satisfaction on pain management at 48 h (1 p. bad, 10 p. good) |
Parikh [10] | 2011, India | Open renal surgery | 60 | General anesthesia | Age 18–70, ASA 1–2 class | VAS (0–10 cm) every 15 min at the first hour, and then at 4, 8, 12, 16, and 24 h after surgery |
Bilgen [11] | 2012, Turkey | C-section | 140 | General anesthesia | ASA 1–2 class, primiparas with an indication for C-section | NPS (0–10 p.) at 2, 6, 18, 24, 48 h after surgery |
Mendola [12] | 2012, Italy | Muscle-sparing posterolateral thoracotomy | 62 | General and epidural anesthesia | ASA 1–3 class | NPS (0–10 p.) at 1, 2, 4, 12, 18, 24 h and every 6 h following 3 days after surgery and 2 times a day until discharge |
Song [13] | 2013, Korea | 1–2 level posterior lumbar fusion | 50 | General anesthesia | ASA 1–2 class, non-smoking women, age 20–65, with a risk for postoperative nausea and vomiting | VAS (0–100 mm) at 30 min, 6, 12, 24, 36, 48 h after surgery at rest and movement |
Nielsen [14] | 2017, Denmark | 1–2 level middle lumbar fusion | 147 | General anesthesia | Chronic back pain for >3 months, age 18–85, ASA 1–3 class, BMI 18–40 kg/m2, opioid usage for >6 months | VAS (0–100 mm) at 2, 6, 12, 18, 25 h after surgery at rest ant movement |
Honarmand [15] | 2011, Iran | Appendectomy | 90 | General anesthesia | ASA 1–2 class, age 18–60, no abscess or perforation | VAS (0–10 cm) at 0, 10, 20, 30 min, 6–12–18–24 h after surgery. |
Menkiti [16] | 2012, Nigeria | C-section | 56 | General anesthesia | ASA 1–2 class, age 18–60, no abscess or perforation | VAS (0–10 cm) at 0, 10, 20, 30 min, 6–12–18–24 h after surgery. |
Nesek-Adam [17] | 2012, Croatia | Laparoscopic cholecystectomy | 80 | General anesthesia | ASA 1–2 class, age 18–70 | VAS (0–10 cm) and numeric pain scale (0–4 p.) 0, 1, 2, 4, 6, 12, 24 h after the surgery. Overall satisfaction evaluated after 24 h (1–5 p.) |
Yazigi [18] | 2012, Lebanon | Lobectomy during posterior dorsal thoracotomy, while having lung cancer | 60 | General anesthesia and intercostal nerve block | ASA 2–3 class | VAS (0–100 mm) 1, 6 12, 18, 24, 30, 36, 42, 48, 54, 60, 66, 72 h after the surgery. Ramsav sedation scale (1–6 p.) |
Kim [19] | 2013, Korea | Posterior decompression and posterior lumbar spinal cord surgery | 60 | General anesthesia | ASA 1–2 class | VAS (0–100 mm) 1, 6, 24, 48 h after the surgery and movement. Overall satisfaction evaluated after 48 h (1–5 p.) |
Han [20] | 2013, Korea | C-section | 36 | Spinal anesthesia | ASA 1–2 class, between 37 and 42 weeks of pregnancy | VAS (0–10) 2, 6, 24, 48 h after the surgery at a rest and while coughing Overall satisfaction evaluated after 48 h (1–5 p.) |
Rahmanian [21] | 2015, Iran | C-section | 160 | Spinal anesthesia | Singleton pregnancy | Numeric pain scale (0–10 p.) 1, 2, 6, 12 h after the surgery |
Kaur [22] | 2015, India | Open cholecystectomy | 80 | General anesthesia | ASA 1–2 class | VAS (0–100 mm) 0, 2, 4, 6, 12, 24 h after the surgery. Overall satisfaction evaluated after 24 h (1–5 p.) Nausea and sedation evaluation (0–3 p.) |
Haliloglu [23] | 2016, Turkey | C-section | 52 | General anesthesia | ASA 1–2 class | Numeric pain scale (0–10 p.) 15 min, 2, 6, 12, 18, 24 h after the surgery |
Chumbley [24] | 2019, UK | Thoracotomy | 70 | Not specified | ≥18 years, able to read English | Numeric pain scale (0–10 p.) 24, 48 h after the surgery at a rest and while coughing |
Boenigk [25] | 2019, USA | Two or more levels of lumbar spinal cord surgery | 124 | General anesthesia | ASA 1–3 class | Numeric pain scale (0–10 p.) 0, 30 min. 1, 1. 5, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24 h after the surgery |
Ates [26] | 2020, Turkey | Septorhinoplasty | 48 | General anesthesia | ASA 1–2 class | VAS (0–10 cm) 0, 1, 2, 4, 8, 12, 24 h after the surgery. Overall satisfaction is evaluated (1–5 p.) |
Descriptive characteristics of the different trials which researched ketamine’s bolus, infusion, or both.
All 18 trials (bolus/infusion/both) included in this systematic review were investigated and compared in three categories—pain, overall satisfaction, and adverse reactions (AR). The summarized results can be seen in Table 2.
Author | Research group (RG) | Control/other group (CG) | Postoperative pain management | Results | |||
---|---|---|---|---|---|---|---|
Pain | Overall satisfaction | Adverse reaction | Overall | ||||
Bolus and infusion during and after surgery | |||||||
Subramaniam | Intravenous (IV) ketamine bolus 0.15 mg/kg for induction and continuous infusion at 2 μg/kg/min during and after surgery for 24 h | Same scheme, but instead of ketamine IV NaCl 0.9% | Patient-controlled analgesia (PCA)—hydromorphone 0.125 boluses every 5 min (max 1.25 mg/h). Epidural block with bupivacaine. Nausea and vomiting—IV ondansetron 4 mg. | Not statistically significant | Not statistically significant | Not statistically significant, the control group experienced nausea and AR-related to central nervous system (CNS) more often | — |
Kim | RG1—IV 1 μg/kg/min ketamine infusion started before incision and continued for 48 h and 0.5 mg/kg ketamine bolus///RG2—same scheme, but infusion at 2 μg/kg/min and bolus 0.5 mg/kg | Same scheme, but instead of ketamine—IV NaCl 0.9% | PCA with fentanyl—15 μg bolus max every 5 min. Nausea or vomiting—IV 10 mg metoclopramide/4 mg ondansetron. | RG2 used less fentanyl than CG and RG1 ( | Same results among the group | No one had hallucinations or nightmares. Other things—not statistically significant | + |
Chumbley | IV 0.1 mg/kg ketamine bolus 10 min before surgery and IV 0.1 μg/kg/h ketamine infusion for 96 h | Same scheme, but instead of ketamine—unknown placebo | Differ—thoracic epidural infusion/PCA ± paravertebral infusion of a local anesthetic | NPC 48 h after surgery lower in RG ( | Not examined | RG had vivid dreams and felt weaker than CG ( Nausea, vomiting, rash, and sedation did not differ. | + |
Yazigi | Before the incision IV 0.1 mg/kg ketamine bolus IV 0.05 mg/kg/h ketamine infusion for 72 h | Same scheme, but instead of ketamine—IV NaCl 0.9% | 72 h after the surgery—1 mg/mL 0.1 mL/kg/h bupivacaine through intercostal catheter. Also IV 1 g paracetamol, 50 mg ketoprofen every 6 h. If VAS > 40 mm—morphine sulfate titrated 2 mg bolus max every 5 min, max dose 0.1 mg/kg/h | No statistical difference—while coughing ( | Not examined | Not statistically significant for sedation, dizziness, nausea, or vomiting. For two patients in RG had hallucinations, impaired vision, or nightmares. | — |
Bolus and infusion only during surgery | |||||||
Parikh | After the induction IV 10 mL (1 mg/mL–0.15 mg/kg) ketamine bolus and 50 mL (1 mg/mL–0.12 mL/kg/h-2 μg/kg/min) infusion until the end of the surgery | Same scheme, but instead of ketamine—IV NaCl 0.9% | When VAS > 40 - > morphine 1 mg | In the first 12 h after the surgery VAS was lower in the RG. In RG 5 patients needed an additional analgesic, in CG all patients needed it so morphine consumption at RG was lower than in the KG. | Not examined | Four patients in RG felt nausea or vomiting. | + |
Nielsen | IV 0.5 mg/kg S-ketamine bolus after the induction and IV 0.25 mg/kg ketamine infusion until the last stich | Same scheme, but instead of ketamine—IV NaCl 0.9% | For everyone in the first 24 h—1 g paracetamol, orally every 6 h started from the 2nd h. PCA with 2.5 mg morphine boluses max every 5 min. For nausea or vomiting IV 4 mg ondansetron - > if not effective—droperidol | No statistical difference—when moving ( | Not statistically significant | Not statistically significant, but vomiting less frequent in the RG at 0–24 h. | + |
Haliloglu | At induction IV 0.5 mg/kg ketamine bolus and infusion 0.25 mg/kg/h until the end of operation | Same scheme, but instead of ketamine—IV NaCl 0.9% | NPS >4 in the recovery room - > 0.05 mg/kg morphine. PCA 0.5 mg/kg morphine at 1 mg boluses max every 10 min. If PCA not efficient—IV 75 mg diclofenac. | 15 min after the surgery NPS lower in the RG ( | Not examined | Spontaneous, involuntary eye movement, hallucinations, and dual vision did not occur to anyone. Most patients experienced nausea, vomiting, and itching, but no statistical difference (p > 0.05). | + |
Kaur | IV 0.2 mg/kg ketamine bolus and infusion 0.1 mg/kg/h until the end of operation | Same scheme, but instead of ketamine—IV NaCl 0.9% | VAS >30 mm—IV 0.05 mg/kg morphine bolus. Medium and strong nausea–IV 0.1 mg/kg ondansetron | During the first 6 h, VAS was lower in the RG ( | Not statistically significant | No one experienced hallucinations, sedation, headache, dizziness, breathing disorder. Nausea and vomiting were similar, but statistically not different. | + |
Ates | At induction IV 0.5 mg/kg ketamine bolus and 0.25 mg/kg/h infusion continued during operation | Same scheme, but instead of ketamine—IV NaCl 0.9% | For everyone at 12 and 24 h after the surgery—50 mg dexketoprofen. If VAS ≥ 4–1 mg/kg tramadol. | VAS was greater in the CG at 30 min. 1, 2, 4, 8, 12, 24 h ( | Higher in the RG ( | Nausea was more intense in the CG, but not statistically. RG did not experience hallucinations, arrhythmias, or vomiting. | + |
Han | IV 0.5 mg/kg ketamine bolus and infusion 0.25 mg/kg/h during surgery | Same scheme, but instead of ketamine—IV NaCl 0.9% | PCA with 25 μg/mL fentanyl—as needed, max every 15 min. If VAS ≥ 5 or patient request—intramuscular 30 mg ketorolac. | At 2 h RG used less fentanyl ( | Not statistically significant. | No one experienced hallucinations or nightmares. | — |
Bolus | |||||||
Bilgen | Before the induction IV: RG1—ketamine 0.25 mg/kg; RG2—ketamine 0.5 mg/kg; RG3—ketamine 1 mg/kg bolus. | Same scheme, but instead of ketamine—IV NaCl 0.9% | PCA for 48 h after the surgery - > morphine chloride 0.5 mg/mL - > 1 mg bolus every 10 min. If needed—IV 75 mg diclofenac every 12 h. If NPS > 4, additional IV morphine 0.005 mg/kg. | No statistical difference ( | Not examined | No statistical difference ( | — |
Song | After induction IV 0.3 mg/kg ketamine bolus + PCA (fentanyl 20 μg/kg, ondansetron 9 mg, ketamine 3 mg/kg) | Same scheme, but instead of ketamine—IV NaCl 0.9% | PCA and 25 mg meperidine, when VAS > 40 mm or if the patient asks. When nausea >6 points (in the system of 10 points, 0—no nausea, 10 strong and unbearable nausea) or if a patient asks—IV 4 mg ondansetron | No statistical difference—when moving or at the rest. RG used less fentanyl 48 h after the surgery ( | Not examined | RG felt nausea more common than CG at 0–6 h ( | + |
Honarmandt | IV 0.5 mg/kg 3 mL ketamine 15 min before the incision | Subcutaneous 0.5 mg/kg 3 mL ketamine///subcutaneous infiltration of NaCI 0.9% 3 mL 15 min before the incision | If VAS > 4 cm—IV 0.4 mg/kg meperidine - > if it does not help in 10 min - > 0.2 mg/kg. Do not exceed 2 mg/kg in 4 h. Nausea >10 min. –0.1 mg/kg metroclopramide IV - > if needed, repeat after 1 h. | VAS scores were lower at 10, 20, 30 min in ketamine groups ( | Not examined | Sedation did not differ. AR did not differ, no one had delirium, hallucinations, or nightmares. | + |
Menkiti | IV 0.15 mg/kg 2 mL ketamine bolus after spinal anesthesia | Same scheme, but instead of ketamine—IV NaCl 0.9% | If VAS >3 IV 75 mg diclofenac. If it does not help - > 30 mg pentazocine 0, every 4 h and 75 mg diclofenac every 8 h if needed. | CG VAS was bigger at 60, 90, 120 min. Statistically significant VAS > 3 p. differed at 90, 120, 150 min. RG received less analgesic after the surgery ( | Not examined | No significant difference, usually hypotension, trembling. | + |
Adam | IV 100 mL NaCl 0.9% 20 min. Before anesthesia and 0.15 mg/kg 5 mL IV ketamine before incision///IV 1 mg/kg diclofenac in 100 mL NaCl 0.9% 20 min before anesthesia and 5 mL IV NaCl 0.9% before incision///IV 1 mg/kg diclofenac in 100 mL NaCl 0.9% 20 min before anesthesia and IV 0.15 mg/kg 5 mL ketamine before incision | IV 100 mL NaCl 0.9% 20 min before anesthesia and 5 mL IV NaCl 0.9% before incision | If VAS > 4—diclofenac IV. If no effect—IV 1.25 g metamizole and IV 100 mg tramadol in 100 mL 0.9% NaCl per 20 min. | VAS max 1 h after surgery. Ketamine and diclofenac group pain scores lower than CG at 1, 2, 4, 6 h and lower than ketamine group at 1, 2 h. During the first 6 h, pain scores were higher in CG rather than the ketamine and diclofenac group. During the first 4 h, ketamine and diclofenac are better than only ketamine. Diclofenac is better than CG or ketamine group at 2.6 h and 2.4 h, respectively. | Not statistically significant | Not statistically significant | — |
Rahmaniam | 5 min after delivery—IV 0.25 mg/kg ketamine bolus | Same scheme, but instead of ketamine IV NaCl 0.9% | If asked—100 mg rectal diclofenac suppository max every 6 h, max 4 times in 24 h. If NPS ≥5—intramuscular 50 mg petidine, max 2 times in 24 h. | CG VAS bigger that RG at 1, 2, 6, 12 h ( | Not examined | Vomiting is more common in CG ( | + |
Infusion during and after surgery | |||||||
Mendola | Before first incision IV 0.1 mg/kg/h ketamine infusion for 60 h | Same scheme, but instead of ketamine—IV NaCl 0.9% | If VAS > 3 p.— > PCA 5 mL max every 60 min. If not—1) IV paracetamol 45 mg/kg, 2) IV ketorolac 1.5 mg/kg, 3) morphine | Not statistically significant between NPS. 0.1 day after surgery RG needed more analgesics ( | Not examined | Not statistically significant. RG 32, 5 vs. CG 25% experienced nausea, vomiting, hypotension, neurological symptoms. | + |
Boenigk | IV 0.12 mg/kg ketamine infusion for 24 h and 0.2 mg/kg ketamine bolus during the first 30 min into Recovery Room | Same scheme, but instead of ketamine—IV NaCl 0.9% and same ketamine bolus | PCA with hydromorphone—0.2 mg max every 6 min, max 2 mg/h for 24 h in the Recovery Room. If NPS > 4—IV 0.2–0.3 mg hydromorphone. | Not statistically significant between NPS. Opioid-tolerant in RG consumed more hydromorphone than opioid-tolerant in CG ( | Not examined | Not statistically significant | + |
Results of studies included in a systematic review.
Subramaniam and colleagues [9] conducted a trial wanting to find out ketamine impact on pain management after laminectomy. Pain scores remained high despite analgesic therapy with ketamine, epidural bupivacaine, PCA with hydromorphone, and other adjuvants. No adverse reactions in the ketamine group were observed. Meanwhile, Kim with fellow authors [19] conducted a similar trial, but in PCA, they used fentanyl. Their research revealed that 0.5 mg/kg ketamine bolus and 2 μg/kg/min ketamine infusion statistically significantly lower fentanyl doses in the first 48 hours after surgery without more frequent adverse reactions. In both trials, pain evaluation in points did not differ.
Chumbley with colleagues’ [24] trial revealed that 0.1 mg/kg IV ketamine bolus and 0.1 mg/kg/h infusion, started 10 min before thoracotomy, lowers consumption of opioids and pain scores at 48 h after surgery.
Yazigi with co-authors [18] injected IV 0.1 mg/kg ketamine bolus before the surgery and IV ketamine infusion of 0.05 mg/kg was continued for 72 hours after lobectomy during thoracotomy, same as bupivacaine that was injected through the intercostal catheter for 72 hours. Ketamine did not have any significant difference in pain scores, additional morphine consumption, sedation, and other adverse psychomimetic effects.
Parikh with other scientists [10] aimed to find out the efficiency of pain management by using ketamine for patients after open renal surgery. They favored the use of ketamine, as its bolus and infusion started after anesthesia induction which reduced pain scores in the first 12 hours, reduced or delayed the use of additional postoperative morphine, and does not cause a more frequent adverse reaction.
Kaur and colleagues [22] discovered that ketamine bolus and infusion were given only during surgery lowered pain scores in the first 6 hours, reduced opioid consumption, and did not have an adverse effect on patients after cholecystectomy.
Nielsen with co-authors [14] investigated opioid-dependent patients’ pain management with ketamine bolus and infusion after back surgery. They did not find any difference in pain scores during 2–24 hours after surgery, but morphine consumption in the PCA in the first 24 hours was significantly lower in the research group. No statistical significance was observed on patients’ overall satisfaction and adverse reaction rate.
Haliloglu with colleagues [23] researched ketamine bolus and infusion during C-section. Their trial revealed that ketamine reduced postoperative PCA morphine consumption in the first 24 hours, but it did not reduce pain scores in the research group in all hours except for the first 15 min after surgery.
Ates with others [26] injected ketamine bolus and infusion during septorhinoplasty and discovered that it reduces pain scores at every hour and lowers additional consumption of opioids, the adverse reaction occurred less frequently, and overall satisfaction on pain management was better.
Different from other trials, Han with colleagues [20] did not find any statistically significant difference in reducing pain scores, overall satisfaction, and adverse reactions.
Bilgen with other researches [11] evaluated three different IV ketamine bolus doses (0.25, 0.5, 0.1 mg/kg) in patients after C-section. No differences were observed.
Menkiti with colleagues [16] found that VAS > 3 points were significantly more often assessed in the control group at 90, 120, 150 min. Also, the first analgesic was appointed for patients for a short amount of time in the research group.
Rahmaniam with colleagues [21] researched IV ketamine bolus after C-section. In the ketamine group, pain scores were lower in the 1, 2, 6, and 12 hours after surgery. Time until first analgesic and amount of them was lower in the ketamine group. Unfortunately, nausea and hallucinations occurred more frequently in the ketamine group.
Song and fellow co-authors [23] researched IV ketamine bolus (which was also given in the PCA) impacts on pain management after spinal cord surgery. At 48 hours, patients with PCA ketamine used less additional fentanyl than the control group. Also, research group participants experienced nausea at 0–6 hours and felt dizziness for 48 hours.
Honarmand and colleagues [15] discovered that 0.5 mg/kg IV ketamine bolus before appendectomy alleviates pain at 12, 18, and 24 hours better than the same dose given s/c or placebo.
Adam with other researchers [17] researched ketamine and diclofenac effects after laparoscopic cholecystectomy. It showed that ketamine without diclofenac has no significant difference.
Mendola and co-authors [12] were determined to find IV ketamine infusion, continued for 60 hours after surgery, impact on pain management. For 48 hours, the control group required more analgesics than the research group. Adverse reactions were not more common in the ketamine group.
Boenigk and colleagues [25] researched 0.2 mg/kg IV ketamine bolus and 0.12 mg/kg ketamine infusion on patients with and without opioid addiction. Those in the control group who have an addiction used more opioids for postoperative pain management than those who did not have an addiction.
Multimodal analgesia is a key component for adequate and fulfilling postoperative pain management. Ketamine, together with adjuncts such as magnesium, lidocaine, dexamethasone, α2 agonists, incisional infiltration, acetaminophen, nonsteroidal anti-inflammatory drugs, or COX-2 selective given during surgery, is known to lessen the pain postoperatively by preventing neural sensitization that may lead to persistent pain as their primary purpose is to target the pain during various pathways in the central nervous system. Ketamine prescribed intravenously after the surgery may decrease overall opioid use, and it is a good analgesic for patients who develop tolerance to the analgesic properties of opioids [27].
The results of all these researches can be explained in several ways. Firstly, according to the type of surgery, Subramaniam [9] and Kim [19] investigated patients after spinal cord surgery, but Subramaniam [17] used IV ketamine 0.15 mg/kg and Kim [19] used a much bigger dose—0.5 mg/kg IV ketamine bolus. Ketamine was infused at the same speed at 24 and 48 hours, respectively. These reasons may have contributed to better outcomes of the Kim [19] trial, as patients used less postoperative analgesics when compared to the control group. Differently from these trials, Chumbley [24] and Yazigi [18] trial results cannot be explained like that, because IV ketamine bolus dose is the same, but Chumbley [24] used 0.1 mg/kg/h infusion for 48 hours (more common adverse reactions—vivid dreams, poor well-being) and Yazigi [18] used 0.5 mg/kg/h for 78 hours, but the results were favorable to Chumbley [24] where patients needed less additional analgesics. As in Chumbley [24], trial patients felt adverse reactions more frequently the prospects of early rehabilitation of these people would have been weaker.
As for ketamine bolus and infusion only during surgery, we can state that carrying out open renal surgery [10] and cholecystectomy [22], IV ketamine bolus (0.15 mg/kg and 0.2 mg/kg), and infusion (2 μg/kg/min and 2 μg/kg/min) alleviates pain better in the first 12 and 6 hours accordingly, reducing the postoperative amount of analgesics and not causing adverse reactions. Nielsen [14] trial (0.5 mg/kg ketamine bolus and 0.25 mg/kg infusion) showed that patients who used opioids before surgery consume less morphine. Haliloglu [23] and Han’s [20] trials compared IV ketamine bolus 0.5 mg/kg and infusion 0.25 mg/kg—in the first one morphine consumption was lower in the research group for 24 hours, in the second one, no difference was observed. Best results were written in the Ates [26] trial (0.5 IV ketamine bolus and 0.25 mg/kg/h infusion)—pain scores, the demand of postoperative analgesics, and adverse reactions were lower in the ketamine group. Satisfaction of pain management was better in the ketamine group in only this trial.
Three trials compare the ketamine bolus effect on postoperative pain after C-section. In the first one [11], 0.25 mg/kg, 0.5 mg/kg, 1 mg/kg ketamine boluses did not have any impact on any factor. In the second one [16], 0.15 mg/kg ketamine bolus was determined to shorten the time of additional analgesia. In the third one [21], 0.25 mg/kg ketamine bolus revealed the best results—lower pain scores, longer time without analgesics and its dose, but nausea and hallucinations appeared more frequently. During spinal cord surgery [13], 0.3 mg/kg IV ketamine bolus triggered nausea and dizziness but lowered the number of additional analgesics. What is interesting, 0.5 mg/kg IV ketamine bolus caused fewer adverse reactions after appendectomy but also alleviated pain effectively in the first 24 hours after surgery [15]. A dose of 0.15 mg/kg IV ketamine bolus during laparoscopic cholecystectomy did not show any better results than a placebo. In only one trial, researchers investigated overall satisfaction which did not differ between the ketamine and placebo groups [17].
Comparing trials that investigated only ketamine infusion efficiency, we can summarize them into few fields—pain scores were not lower neither 0.1 mg/kg/h nor 0.12 mg/kg/h IV ketamine infusion. In the first research [12], the ketamine group required fewer postoperative analgesics. The same results were shown in the second trial, where patients before surgery used opioids [25]. Adverse reactions did not differ in any trial.
Pain intensity evaluated while using ketamine:
Bolus and infusion (during and after surgery)—IV combination of 0.5 mg/kg ketamine bolus and 1 μg/kg/min infusion successfully lowered the necessity of postoperative analgesics,
Bolus and infusion (during surgery)—IV combination of 0.5 mg/kg ketamine bolus and 0.25 mg/kg/h infusion successfully reduced postoperative pain and IV 0.2–0.5 mg/kg bolus and 0.1–0.25 mg/kg/h infusion meaningfully diminished consumption of postoperative analgesics,
Infusion (during and after surgery)—IV 0.1 mg/kg/h ketamine bolus reduced consumption of postoperative analgesics,
Bolus—less analgesics were used when IV bolus dose were 0.25–0.3 mg/kg and IV 0.5 mg/kg bolus eased pain better for the first 24 h, 0.25 mg/kg for 12 h, 0.15 mg/kg for 3 hours.
In 17 trials, overall well-being and satisfaction of pain management did not differ between ketamine and placebo and in one trial, 0.5 mg/kg ketamine bolus and 0.25 mg/kg/h infusion were associated with better results.
Adverse reactions were more common in three pieces of research—the first being IV 0.1 mg/kg ketamine bolus and 0.1 mg/kg/infusion; second—IV 0.25 mg/kg ketamine bolus; and third—IV 0.3 mg/kg ketamine bolus, thus meaning that the early rehabilitation of patients in the rest of the trials would have been good.
These recommendations are prepared in accordance with guidelines issued in 2018 [6]:
Subanesthetic ketamine infusions should be considered for patients undergoing painful surgery (upper and lower abdominal, thoracic, and orthopedic (limbs and spine)).
Ketamine should be considered for both opioid-tolerant and opioid-dependent patient groups.
Ketamine bolus should not exceed 0.35 mg/kg, infusion 1 mg/kg/g dose, but it should always be considered according to a patient’s factors.
Patients with cardiovascular disease, pregnant women, patients with active psychosis, hepatic dysfunction, elevated intracranial, and intraocular pressure should avoid using ketamine.
Intranasal ketamine should be considered using for children during short-time procedures and for whom intravenous ketamine is difficult to inject. Intranasal ketamine is effective for acute pain management and for amnesia and sedation during the procedure.
Evidence for the benefit of IV-PCA: Delivered ketamine as the only analgesic for acute pain is limited and there is moderate evidence for the benefit of the addition of ketamine to an opioid-based IV-PCA for acute and perioperative pain management.
The authors declare no conflict of interest.
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Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8436",title:"Sandy Materials in Civil Engineering",subtitle:"Usage and Management",isOpenForSubmission:!1,hash:"b448d888478a3a8836bb6dca78facaf8",slug:"sandy-materials-in-civil-engineering-usage-and-management",bookSignature:"Saeed Nemati and Farzaneh Tahmoorian",coverURL:"https://cdn.intechopen.com/books/images_new/8436.jpg",editedByType:"Edited by",editors:[{id:"296316",title:"Dr.",name:"Saeed",middleName:null,surname:"Nemati",slug:"saeed-nemati",fullName:"Saeed Nemati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8757",title:"Compressive Strength of Concrete",subtitle:null,isOpenForSubmission:!1,hash:"2170e51b425059296e5464e0fe13f237",slug:"compressive-strength-of-concrete",bookSignature:"Pavlo Kryvenko",coverURL:"https://cdn.intechopen.com/books/images_new/8757.jpg",editedByType:"Edited by",editors:[{id:"180922",title:"Prof.",name:"Pavel",middleName:null,surname:"Krivenko",slug:"pavel-krivenko",fullName:"Pavel Krivenko"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5214",title:"High Performance Concrete Technology and Applications",subtitle:null,isOpenForSubmission:!1,hash:"4f7096ba0b4812663b72c918c4a4eff7",slug:"high-performance-concrete-technology-and-applications",bookSignature:"Salih Yilmaz and Hayri Baytan Ozmen",coverURL:"https://cdn.intechopen.com/books/images_new/5214.jpg",editedByType:"Edited by",editors:[{id:"75636",title:"Associate Prof.",name:"Salih",middleName:null,surname:"Yilmaz",slug:"salih-yilmaz",fullName:"Salih Yilmaz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:5,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"66446",doi:"10.5772/intechopen.85675",title:"Compressive Behavior of Concrete under Environmental Effects",slug:"compressive-behavior-of-concrete-under-environmental-effects",totalDownloads:1150,totalCrossrefCites:10,totalDimensionsCites:33,abstract:"Concrete strength is fairly sensitive to environmental effects. Extreme weather conditions and changes in humidity rates significantly affect the concrete compressive strength development. Concrete as one of the substantial material used in residential buildings and infrastructures is subjected to a massive strength change under extreme weather conditions. For understanding, the different concrete’s behavioral aspects, various commercial cement types under different temperatures, and humidity rates are investigated in this chapter. The experiments are aimed to investigate the concrete strength development over time when the material is cast at lower to mild temperatures and different humidity index rates. Results show that reducing the curing temperature more than 15° could result in 20% reduction in total compressive strength, while decreasing humidity rates by 50% leads to less than 10% drop in ultimate strength. To understand the strength developing process, maturity tests are conducted. It is shown that concrete is not able to reach to the expected ultimate strength if the temperature is significantly low regardless of curing time. The effect of temperature change during the curing process is more tangible on strength development compared to cement type and humidity rate values.",book:{id:"8757",slug:"compressive-strength-of-concrete",title:"Compressive Strength of Concrete",fullTitle:"Compressive Strength of Concrete"},signatures:"Alireza Farzampour",authors:null},{id:"51720",doi:"10.5772/64574",title:"Microstructure of Concrete",slug:"microstructure-of-concrete",totalDownloads:4908,totalCrossrefCites:16,totalDimensionsCites:21,abstract:"Concrete is a composite material that consists of a binding medium and aggregate particles and can be formed in several types. It may be considered to consist of three phases: a cement paste, the aggregate, and the interfacial transition zone (ITZ) between them. In addition to ordinary Portland cement, the essential components of the base of concrete are aggregates and water. For practical requirements, additives and admixtures can be added to these raw materials to improve some desirable characteristics. The following requirements should be considered in producing high performance concrete (HPC): (i) low water/cement (w/c) ratio; (ii) fine aggregate; (iii) large quantity of mineral additives, silica fume, and fly ash; (iv) high dosage of superplasticizer; and (v) high-pressure steam curing. The microstructure of high performance concrete (HPC) is more homogenous than that of normal concrete (NC) due to the physical and chemical contribution of the additives (silica fume and fly ash) as well as it is less porous due to reduced w/c ratio with the addition of a superplasticizer. Inclusion of additives (individually or in combination) helped in improving the strength and durability of concrete mixes due to the additional reduction in porosity of cement paste and an improved interface between it and the aggregate.",book:{id:"5214",slug:"high-performance-concrete-technology-and-applications",title:"High Performance Concrete Technology and Applications",fullTitle:"High Performance Concrete Technology and Applications"},signatures:"Ameer A. Hilal",authors:[{id:"180518",title:"Dr.",name:"Ameer",middleName:null,surname:"Hilal",slug:"ameer-hilal",fullName:"Ameer Hilal"}]},{id:"51861",doi:"10.5772/64779",title:"Concretes with Photocatalytic Activity",slug:"concretes-with-photocatalytic-activity",totalDownloads:2861,totalCrossrefCites:8,totalDimensionsCites:15,abstract:"This chapter is a short review about the modified concretes with photocatalytic activity. In the beginning, the photocatalysis process is explained; the authors are focused on the mechanism of organic contamination and nitrogen oxide decomposition. Next the three main methods for concretes modification are presented: the first group is when the concrete is covered by thin layer of TiO2 materials, e.g., paints or TiO2 suspensions. The second group is the concretes with thick layer of photoactive concrete on the top. The third group constitutes concretes modified in mass with TiO2. The two main methods for photocatalytic activity of the modified concrete determination were shown: an air purification by a nitrogen oxide decomposition and the self-cleaning properties by dyes decomposition. Also in this chapter the mechanical properties of the modified concrete are presented. In the end, the examples of the buildings made of photocatalytic concretes are shown.",book:{id:"5214",slug:"high-performance-concrete-technology-and-applications",title:"High Performance Concrete Technology and Applications",fullTitle:"High Performance Concrete Technology and Applications"},signatures:"Magdalena Janus and Kamila Zając",authors:[{id:"180824",title:"Associate Prof.",name:"Magdalena",middleName:null,surname:"Janus",slug:"magdalena-janus",fullName:"Magdalena Janus"}]},{id:"51409",doi:"10.5772/64386",title:"Application of Polypropylene Fibrillated Fibres for Reinforcement of Concrete and Cement Mortars",slug:"application-of-polypropylene-fibrillated-fibres-for-reinforcement-of-concrete-and-cement-mortars",totalDownloads:2460,totalCrossrefCites:2,totalDimensionsCites:6,abstract:"Polypropylene fibres have been applied for reinforcement of cement mortars and concrete for many years. The fibres restrict crack propagation and positively affect several concrete parameters. To improve the adhesion of polypropylene to cement matrix, geometrically deformed or modified fibres are commonly used. Good results are obtained by application of fibrillated fibres with the net-like structure obtained from the polypropylene types. The fibrillated polypropylene fibres were produced. The fibres were chopped to specified lengths and used for the reinforcement of concrete and cement mortars. The parameters of fresh concrete and mechanical parameters of reinforced concrete and mortar were determined. It was stated that the fibres do not affect the compressive strength of the reinforced concrete and mortar. The beneficial effect of fibres on the compressive strength of concrete is revealed after freezing and thawing cycles. The fibres influence the bending strength of the mortars. For mortars reinforced with fibrillated fibres a significant increase in the bending strength is observed. The increase in the bending strength results from enhanced interfacial adhesion and mechanical anchoring, which results from opening of the network structure and splitting of fibrillated fibres.",book:{id:"5214",slug:"high-performance-concrete-technology-and-applications",title:"High Performance Concrete Technology and Applications",fullTitle:"High Performance Concrete Technology and Applications"},signatures:"Jan Broda",authors:[{id:"104226",title:"Prof.",name:"Jan",middleName:null,surname:"Broda",slug:"jan-broda",fullName:"Jan Broda"}]},{id:"68188",doi:"10.5772/intechopen.88057",title:"Compressive Strength of Lightweight Concrete",slug:"compressive-strength-of-lightweight-concrete",totalDownloads:1740,totalCrossrefCites:3,totalDimensionsCites:6,abstract:"This chapter has been prepared with the hope that its readers will become interested in lightweight concrete (LWC). Therefore, after a brief background of lightweight concrete, different types of LWC will be introduced and then LWC made of lightweight aggregates (LWA) will be specifically discussed. Compressive strength and density of LWC are the main points of interest in this chapter. In addition to conventional compression test, a nondestructive test (NDT) method will be used to assess the compressive strength of a variety of lightweight concrete mixes. A case study has been designed and conducted including an experimental program on the LWC made of expanded glass aggregate. The experimental program includes about 150 specimens, incorporating different unit weight for the entire specimens. In the end, it can be observed that the properties of LWC depend on the properties of the used LWA, and therefore for each specific type of lightweight aggregate, a brand new equation will be required for prediction of concrete compressive strength. The author hopes that the present chapter and the discussed case study on LWC would attract the attention of researchers to the importance of LWC in the future of construction industry.",book:{id:"8757",slug:"compressive-strength-of-concrete",title:"Compressive Strength of Concrete",fullTitle:"Compressive Strength of Concrete"},signatures:"Saman Hedjazi",authors:null}],mostDownloadedChaptersLast30Days:[{id:"51720",title:"Microstructure of Concrete",slug:"microstructure-of-concrete",totalDownloads:4905,totalCrossrefCites:16,totalDimensionsCites:21,abstract:"Concrete is a composite material that consists of a binding medium and aggregate particles and can be formed in several types. It may be considered to consist of three phases: a cement paste, the aggregate, and the interfacial transition zone (ITZ) between them. In addition to ordinary Portland cement, the essential components of the base of concrete are aggregates and water. For practical requirements, additives and admixtures can be added to these raw materials to improve some desirable characteristics. The following requirements should be considered in producing high performance concrete (HPC): (i) low water/cement (w/c) ratio; (ii) fine aggregate; (iii) large quantity of mineral additives, silica fume, and fly ash; (iv) high dosage of superplasticizer; and (v) high-pressure steam curing. The microstructure of high performance concrete (HPC) is more homogenous than that of normal concrete (NC) due to the physical and chemical contribution of the additives (silica fume and fly ash) as well as it is less porous due to reduced w/c ratio with the addition of a superplasticizer. Inclusion of additives (individually or in combination) helped in improving the strength and durability of concrete mixes due to the additional reduction in porosity of cement paste and an improved interface between it and the aggregate.",book:{id:"5214",slug:"high-performance-concrete-technology-and-applications",title:"High Performance Concrete Technology and Applications",fullTitle:"High Performance Concrete Technology and Applications"},signatures:"Ameer A. Hilal",authors:[{id:"180518",title:"Dr.",name:"Ameer",middleName:null,surname:"Hilal",slug:"ameer-hilal",fullName:"Ameer Hilal"}]},{id:"70930",title:"The Influence of Interfacial Transition Zone on Strength of Alkali-Activated Concrete",slug:"the-influence-of-interfacial-transition-zone-on-strength-of-alkali-activated-concrete",totalDownloads:925,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"A process of structure formation taking place in the interfacial transition zone (ITZ) “cement stone-aggregate” was studied on a variety of concretes made with artificial and real aggregates. The study of these processes in the case of artificial aggregate prepared from a mixture of clay loam and alkali-activated slag cement showed that not only active SiO2 and Na2O but also other substances of both cement and aggregate are involved in the formation of the ITZ. This results in the formation of alkaline and alkaline-alkali-earth aluminosilicate hydrates which strengthen the ITZ and improve strength and durability of the concrete. Thus, the alkali-silica reaction (ASR) transforms from a destructive one (negative effect) into a constructive one (positive effect). The study on the ITZ in the alkali-activated cement concretes made with real alkali-susceptible aggregates selected from crushed basalt rock, glassy waste product from basalt fiber production, crushed perlite rock, and expanded perlite suggested to make a conclusion on the possibility to prevent the destructive processes in the ITZ through the addition of the metakaolin additive into the cement composition in quantities of 5–10% by mass. These conclusions were supported by the long-term testing of strength of these concretes, by measuring the deformations “shrinkage-expansion” as well as the results of study on hardness of the ITZ.",book:{id:"8757",slug:"compressive-strength-of-concrete",title:"Compressive Strength of Concrete",fullTitle:"Compressive Strength of Concrete"},signatures:"Pavel Krivenko, Oleh Petropavlovskyi, Oleksandr Kovalchuk and Oleksandr Gelevera",authors:null},{id:"68188",title:"Compressive Strength of Lightweight Concrete",slug:"compressive-strength-of-lightweight-concrete",totalDownloads:1738,totalCrossrefCites:3,totalDimensionsCites:6,abstract:"This chapter has been prepared with the hope that its readers will become interested in lightweight concrete (LWC). Therefore, after a brief background of lightweight concrete, different types of LWC will be introduced and then LWC made of lightweight aggregates (LWA) will be specifically discussed. Compressive strength and density of LWC are the main points of interest in this chapter. In addition to conventional compression test, a nondestructive test (NDT) method will be used to assess the compressive strength of a variety of lightweight concrete mixes. A case study has been designed and conducted including an experimental program on the LWC made of expanded glass aggregate. The experimental program includes about 150 specimens, incorporating different unit weight for the entire specimens. In the end, it can be observed that the properties of LWC depend on the properties of the used LWA, and therefore for each specific type of lightweight aggregate, a brand new equation will be required for prediction of concrete compressive strength. The author hopes that the present chapter and the discussed case study on LWC would attract the attention of researchers to the importance of LWC in the future of construction industry.",book:{id:"8757",slug:"compressive-strength-of-concrete",title:"Compressive Strength of Concrete",fullTitle:"Compressive Strength of Concrete"},signatures:"Saman Hedjazi",authors:null},{id:"51409",title:"Application of Polypropylene Fibrillated Fibres for Reinforcement of Concrete and Cement Mortars",slug:"application-of-polypropylene-fibrillated-fibres-for-reinforcement-of-concrete-and-cement-mortars",totalDownloads:2459,totalCrossrefCites:2,totalDimensionsCites:6,abstract:"Polypropylene fibres have been applied for reinforcement of cement mortars and concrete for many years. The fibres restrict crack propagation and positively affect several concrete parameters. To improve the adhesion of polypropylene to cement matrix, geometrically deformed or modified fibres are commonly used. Good results are obtained by application of fibrillated fibres with the net-like structure obtained from the polypropylene types. The fibrillated polypropylene fibres were produced. The fibres were chopped to specified lengths and used for the reinforcement of concrete and cement mortars. The parameters of fresh concrete and mechanical parameters of reinforced concrete and mortar were determined. It was stated that the fibres do not affect the compressive strength of the reinforced concrete and mortar. The beneficial effect of fibres on the compressive strength of concrete is revealed after freezing and thawing cycles. The fibres influence the bending strength of the mortars. For mortars reinforced with fibrillated fibres a significant increase in the bending strength is observed. The increase in the bending strength results from enhanced interfacial adhesion and mechanical anchoring, which results from opening of the network structure and splitting of fibrillated fibres.",book:{id:"5214",slug:"high-performance-concrete-technology-and-applications",title:"High Performance Concrete Technology and Applications",fullTitle:"High Performance Concrete Technology and Applications"},signatures:"Jan Broda",authors:[{id:"104226",title:"Prof.",name:"Jan",middleName:null,surname:"Broda",slug:"jan-broda",fullName:"Jan Broda"}]},{id:"51780",title:"High-Performance Concrete and Fiber-Reinforced High- Performance Concrete under Fatigue Efforts",slug:"high-performance-concrete-and-fiber-reinforced-high-performance-concrete-under-fatigue-efforts",totalDownloads:2338,totalCrossrefCites:2,totalDimensionsCites:4,abstract:"Fatigue is the process of mechanical degradation of a material, which leads to its collapse. Repeated load applications with a maximum value lower than the one that provokes the static failure of the material, causes internal damage in the material that, progressively, reduces its mechanical capacity until it finally collapses. The increasingly widespread use of high-strength concretes permits the construction of more lightweight structures. This implies that the variable loads (which are the causes of fatigue) represent an ever larger percentage of the total load. In consequence, fatigue is an increasingly important factor in concrete structures. In some cases, it even begins to be the dimensioning load of the structure. In addition, the presence of fibers within the concrete modifies the fatigue response of the concrete. In this chapter, the classic theory of fatigue is presented in detail and the most recent developments in the study of concrete fatigue are discussed.",book:{id:"5214",slug:"high-performance-concrete-technology-and-applications",title:"High Performance Concrete Technology and Applications",fullTitle:"High Performance Concrete Technology and Applications"},signatures:"Miguel A. Vicente, Jesús Mínguez, José A. Martínez and Dorys C.\nGonzález",authors:[{id:"181643",title:"Prof.",name:"Miguel",middleName:null,surname:"Vicente",slug:"miguel-vicente",fullName:"Miguel Vicente"},{id:"182032",title:"Prof.",name:"Jesus",middleName:null,surname:"Minguez",slug:"jesus-minguez",fullName:"Jesus Minguez"},{id:"182033",title:"Prof.",name:"Jose Antonio",middleName:null,surname:"Martinez",slug:"jose-antonio-martinez",fullName:"Jose Antonio Martinez"},{id:"182034",title:"Prof.",name:"Dorys",middleName:null,surname:"Gonzalez",slug:"dorys-gonzalez",fullName:"Dorys Gonzalez"}]}],onlineFirstChaptersFilter:{topicId:"1348",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81503",title:"The Data Representations of a Building Project: BIM Model, and IFC or IFCXML Data Standard",slug:"the-data-representations-of-a-building-project-bim-model-and-ifc-or-ifcxml-data-standard",totalDownloads:28,totalDimensionsCites:0,doi:"10.5772/intechopen.104580",abstract:"Building regulations in the construction industry are legal documents written in human language. These are interpreted and implemented by people and generally controlled by local governments. Traditional building regulation control and supervision methods emerge as a time-consuming and error-prone process for architects, engineers, and public authorities. Therefore, BIM\\'s effective building regulation control is considered a promising field of study in the construction industry. Automated Code Compliance Checking (ACCC) method is a rule-based method that provides simultaneous control of the computer’s building regulations. ACCC takes into account the characteristics of the building elements and related building regulations. BIM is recognized as the most effective platform for information exchange of building projects in the construction industry. It supports the development of various software. It facilitates automated or semi-automated ACCC of the building projects for compliance with building regulations and standards for the participants involved in the building production process. The data of the building project are represented in two ways in the ACCC. These are BIM Model, and IFC or IFCXML Data Standard. In this study, the BIM, IFC, and IFCXML representations of the building project data were explained over the sample housing project in the ACCC process.",book:{id:"11186",title:"Sand in Construction",coverURL:"https://cdn.intechopen.com/books/images_new/11186.jpg"},signatures:"Murat Aydın"},{id:"81506",title:"Bentonite Clay Modified Concrete",slug:"bentonite-clay-modified-concrete",totalDownloads:28,totalDimensionsCites:0,doi:"10.5772/intechopen.103803",abstract:"Replacing cement with pozzolanic materials to some extent in construction is found to be one of the sustainable approaches in the construction industry. Pozzolanic materials of industrial origin like fly ash and Ground Granulated Blast furnace Slag will have to be replaced with natural pozzolanic materials once the world moves towards renewable energy sources. Bentonite is one such pozzolanic clay material that is rich in SiO2 content. A little research was made to assess the performance of bentonite modified concrete. Based on those, an improvement in the fresh, hardened, durability properties was reported. This chapter presents the current scenario on the development of bentonite modified concrete. It also reviews the literature about the physical & chemical properties of bentonite, bentonite blended cement mortar, bentonite modified cement concrete, and reinforced concrete. The history and development of Bentonite modified concrete were also briefly presented in this chapter.",book:{id:"11186",title:"Sand in Construction",coverURL:"https://cdn.intechopen.com/books/images_new/11186.jpg"},signatures:"Metta Achyutha Kumar Reddy and Veerendrakumar C. Khed"},{id:"81381",title:"Oil Contaminated Sand: Sources, Properties, Remediation, and Engineering Applications",slug:"oil-contaminated-sand-sources-properties-remediation-and-engineering-applications",totalDownloads:26,totalDimensionsCites:0,doi:"10.5772/intechopen.103802",abstract:"Oil leakage during the exploration, production, and transportation of crude oil is a significant issue worldwide because crude oil spills severely impact the physical and chemical properties of the surrounding soil. A range of remediation methods for oil-contaminated soil is recommended, consisting of sand washing, bioremediation, electro-kinetic sand remediation, and thermal desorption; however, none are cost-effective. To find a suitable alternative remediation method, oil-contaminated sand utilisation in construction was considered. Several researchers found that oil contamination generally has an adverse effect on the mechanical properties of sand, but certain levels of contamination have beneficial effects on some of the important properties of the sand and its produced concrete. This chapter reviews the main sources of oil contamination and the existing remediation methods for this waste material. It analyses the different factors that affect the properties of oil-contaminated sand and concrete, including the type of crude oil and permeability of sand, like its properties, absorption, chemical composition, and spillage quantity. Furthermore, the intensive evaluation results of light crude oil effects on the geotechnical properties of fine sand, cement mortar and concrete were presented. Potential applications for oil-contaminated sand were also identified for the re-use of this material in engineering and construction.",book:{id:"11186",title:"Sand in Construction",coverURL:"https://cdn.intechopen.com/books/images_new/11186.jpg"},signatures:"Rajab Abousnina and Rochstad Lim Allister"},{id:"81175",title:"Thermal Conductivity and Mechanical Properties of Organo-Clay-Wood Fiber in Cement-Based Mortar",slug:"thermal-conductivity-and-mechanical-properties-of-organo-clay-wood-fiber-in-cement-based-mortar",totalDownloads:23,totalDimensionsCites:0,doi:"10.5772/intechopen.102321",abstract:"This paper orientated to study the compressive resistance and thermal conductivity of compressed and stabilized clay blocks in the cement matrix. The effect of the content of wood fiber (WF) became studied as a reinforcement material in cement mortars. The porosity, compressive energy, thermal conductivity and composite of cement hydration had been investigated. The addition of NFC suggests a very good pore reduction, and the fine result becomes acquired with the emulsion of a combination incorporating 2%wt of WF inside the presence of an anionic surfactant (SDBS). The results revealed that used in this study were a mix of water with ordinary portland cement and organo-clay (OC) modified with Cetyltrimethylammonium bromide at water-to-solid ratios 1%. The effect depending on w/s ratio of OC used samples with cement substitution for organoclay showed from 2% higher compressive strength results than that of the plain cement paste and a decrease of the thermal conductivity by addition of 2%wt of WF from 2.26 to 0.8 W/m °C. It was also observed that with increasing w/s ratio higher amount of cement can be replaced by OC. These analyses have revealed that the presence of WF promoted the hydration, by producing more portlandite and calcium silicate gel.",book:{id:"11186",title:"Sand in Construction",coverURL:"https://cdn.intechopen.com/books/images_new/11186.jpg"},signatures:"Fadhel Aloulou and Habib Sammouda"},{id:"80651",title:"The Effects of Mill Conditions on Breakage Parameters of Quartz Sand in the District of Şile on the Black Sea Coast of İstanbul",slug:"the-effects-of-mill-conditions-on-breakage-parameters-of-quartz-sand-in-the-district-of-ile-on-the-b",totalDownloads:54,totalDimensionsCites:0,doi:"10.5772/intechopen.102554",abstract:"Casting, glass, ceramic, construction, plastic, dyeing, and abrasive industries are the main consumption areas of quartz sand, which are formed as a result of the weathering of igneous metamorphic rocks. In such industries, it is very important to select the correct ball size in order to grind the raw material to the desired particle size in optimum time. In this study, the changes in the specific rate of breakage of the quartz sand sample were investigated by using alloy steel balls of five different sizes. For this purpose, three different mono-size samples were prepared according to 4√2 series in the range of 0.090–0.053 mm. The quartz sand prepared in these three intervals was ground with 6.35, 7.94, 9.52, 12.70, and 19.05 mm alloy steel balls for different durations. The specific rate of breakage values was obtained from the particle size distributions acquired after various grinding periods. As a result of grinding tests, an increase in the rate of breakage is observed due to the increase in ball diameter.",book:{id:"11186",title:"Sand in Construction",coverURL:"https://cdn.intechopen.com/books/images_new/11186.jpg"},signatures:"Serhan Haner"},{id:"80288",title:"The Role of Sand in Mortar’s Properties",slug:"the-role-of-sand-in-mortar-s-properties",totalDownloads:59,totalDimensionsCites:0,doi:"10.5772/intechopen.102489",abstract:"Mortars are diachronic composite materials used in masonry construction to serve multiple roles. Their durability and esthetic harmonization in constructions of the different eras were the reasons why numerous research works have been realized over recent decades. Each time, the role of the mortars’ components revealed significant pieces of information on the technology used. Despite the indisputable role of the binders on the mortar’s quality, aggregates of different characteristics had a significant role in the behavior of mortars. The addition of aggregates to a binding system in mortars technology has proved to confer technical advantages as they contribute to volume stability, durability, and structural performance. Apart from the different types of aggregates, as their mineralogy and origin are concerned, the volume content in the mixture, the maximum size, and their gradation influences the structure of a binder—aggregate mixture and the performance of mortars overall. In the present article, the diachronic presence of mortars is presented. 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He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:{name:"Association for Computing Machinery",country:{name:"United States of America"}}},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:"Manufacturing and Technology Integrated Campus – SENAI CIMATEC",institution:null},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:'"Politechnica" University Timişoara',institution:null},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. 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Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. 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He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. 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