\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"6157",leadTitle:null,fullTitle:"Water Challenges of an Urbanizing World",title:"Water Challenges of an Urbanizing World",subtitle:null,reviewType:"peer-reviewed",abstract:"Global water crisis is a challenge to the security, political stability and environmental sustainability of developing nations and with climate, economically and politically, induces migrations also for the developed ones. Currently, the urban population is 54% with prospects that by the end of 2050 and 2100 66% and 80%, respectively, of the world's population will live in urban environment. Untreated water abstracted from polluted resources and destructed ecosystems as well as discharge of untreated waste water is the cause of health problems and death for millions around the globe. Competition for water is wide among agriculture, industry, power companies and recreational tourism as well as nature habitats. Climate changes are a major threat to the water resources. This book intends to provide the reader with a comprehensive overview of the current state of the art in integrated assessment of water resource management in the urbanizing world, which is a foundation to develop society with secure water availability, food market stability and ecosystem preservation.",isbn:"978-953-51-3894-5",printIsbn:"978-953-51-3893-8",pdfIsbn:"978-953-51-4049-8",doi:"10.5772/intechopen.68339",price:119,priceEur:129,priceUsd:155,slug:"water-challenges-of-an-urbanizing-world",numberOfPages:192,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"bda09a247dff84ce8091d8bd039850b9",bookSignature:"Matjaž Glavan",publishedDate:"March 21st 2018",coverURL:"https://cdn.intechopen.com/books/images_new/6157.jpg",numberOfDownloads:40030,numberOfWosCitations:61,numberOfCrossrefCitations:43,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:96,numberOfDimensionsCitationsByBook:4,hasAltmetrics:1,numberOfTotalCitations:200,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 15th 2017",dateEndSecondStepPublish:"April 5th 2017",dateEndThirdStepPublish:"July 20th 2017",dateEndFourthStepPublish:"September 30th 2017",dateEndFifthStepPublish:"December 20th 2017",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"82604",title:"Dr.",name:"Matjaž",middleName:null,surname:"Glavan",slug:"matjaz-glavan",fullName:"Matjaž Glavan",profilePictureURL:"https://mts.intechopen.com/storage/users/82604/images/3247_n.jpg",biography:"Dr. Matjaž Glavan is an assistant professor of Environmental Planning at Biotechnical Faculty of the University of Ljubljana and the chair for Agrometeorology, Agricultural Land Management, Economics and Rural Development. He completed his BSc degree in Agronomy at the University of Ljubljana, Slovenia, and his MSc degree in Integrated Catchment Management at Cranfield University, UK. He obtained his PhD degree in Biological and Biotechnological Sciences at the University of Ljubljana in 2011. His main field of expertise is integrated water and land management in relation to agriculture. His research focus is also on modelling spatial, economic and environmental impacts of land-use changes and agri-environmental measures on water, soil and land resource quality and quantity. He is also specialized in catchment modelling with the Soil and Water Assessment Tool.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"9",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Ljubljana",institutionURL:null,country:{name:"Slovenia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"837",title:"Hydrology",slug:"hydrology"}],chapters:[{id:"59285",title:"Introductory Chapter: Neglected Tropical Waterborne Infectious Diseases - Strategies for Mitigation",doi:"10.5772/intechopen.74322",slug:"introductory-chapter-neglected-tropical-waterborne-infectious-diseases-strategies-for-mitigation",totalDownloads:1676,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Shailendra K. Saxena, Swatantra Kumar, Amrita Haikerwal and\nMadan L.B. Bhatt",downloadPdfUrl:"/chapter/pdf-download/59285",previewPdfUrl:"/chapter/pdf-preview/59285",authors:[{id:"158026",title:"Prof.",name:"Shailendra K.",surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena"}],corrections:null},{id:"59342",title:"Water Quality Control in the Water Supply System for the Purpose of Preventing Legionnaires’ Disease",doi:"10.5772/intechopen.74018",slug:"water-quality-control-in-the-water-supply-system-for-the-purpose-of-preventing-legionnaires-disease",totalDownloads:1658,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"The contamination of drinking water presents an important public health concern throughout the world. Microbial hazards make the largest contribution to waterborne disease in developed and developing countries. Legionella bacterium, the fundamental agent of Legionnaires’ disease, is a water-based organism that causes infection when inhaled in an aerosol form. Main factors influencing the survival of Legionella spp. are: physical and chemical properties of the water (pH value, mineral content, and presence of heavy metals), materials used in the system, system design, furring, corrosion, and dead-ends. These bacteria are transmitted during the showering by inhalation of contaminated water droplets and the highest risk of infection with a subsequent death is encountered among immunocompromised and elderly water consumers. The control of the disease has been one of the major problems in countries with low- and middle-income economies, including Croatia. The most frequently used approach to disinfect the system is a daily increase of water temperature in the heating coil. However, due to the economic issues, the residents frequently request house managers to decrease the temperature of hot water systems leading to an increased system contamination and subsequent human infections.",signatures:"Anita Rakić",downloadPdfUrl:"/chapter/pdf-download/59342",previewPdfUrl:"/chapter/pdf-preview/59342",authors:[{id:"216117",title:"Dr.",name:"Anita",surname:"Rakić",slug:"anita-rakic",fullName:"Anita Rakić"}],corrections:null},{id:"58138",title:"Water Pollution: Effects, Prevention, and Climatic Impact",doi:"10.5772/intechopen.72018",slug:"water-pollution-effects-prevention-and-climatic-impact",totalDownloads:21500,totalCrossrefCites:18,totalDimensionsCites:37,hasAltmetrics:1,abstract:"The stress on our water environment as a result of increased industrialization, which aids urbanization, is becoming very high thus reducing the availability of clean water. Polluted water is of great concern to the aquatic organism, plants, humans, and climate and indeed alters the ecosystem. The preservation of our water environment, which is embedded in sustainable development, must be well driven by all sectors. While effective wastewater treatment has the tendency of salvaging the water environment, integration of environmental policies into the actor firms core objectives coupled with continuous periodical enlightenment on the present and future consequences of environmental/water pollution will greatly assist in conserving the water environment.",signatures:"Inyinbor Adejumoke A., Adebesin Babatunde O., Oluyori Abimbola\nP., Adelani-Akande Tabitha A., Dada Adewumi O. and Oreofe Toyin\nA.",downloadPdfUrl:"/chapter/pdf-download/58138",previewPdfUrl:"/chapter/pdf-preview/58138",authors:[{id:"101570",title:"MSc.",name:"Babatunde Olufemi",surname:"Adebesin",slug:"babatunde-olufemi-adebesin",fullName:"Babatunde Olufemi Adebesin"},{id:"187738",title:"Dr.",name:"Adejumoke",surname:"Inyinbor",slug:"adejumoke-inyinbor",fullName:"Adejumoke Inyinbor"},{id:"188818",title:"Dr.",name:"Abimbola",surname:"Oluyori",slug:"abimbola-oluyori",fullName:"Abimbola Oluyori"},{id:"188819",title:"Mrs.",name:"Tabitha",surname:"Adelani-Akande",slug:"tabitha-adelani-akande",fullName:"Tabitha Adelani-Akande"},{id:"208501",title:"Dr.",name:"Adewumi",surname:"Dada",slug:"adewumi-dada",fullName:"Adewumi Dada"},{id:"208502",title:"Ms.",name:"Toyin",surname:"Oreofe",slug:"toyin-oreofe",fullName:"Toyin Oreofe"}],corrections:null},{id:"57325",title:"A Temporal Analysis of Water Quality Variability at the Seattle Aquarium in Elliott Bay, Puget Sound, WA",doi:"10.5772/intechopen.71353",slug:"a-temporal-analysis-of-water-quality-variability-at-the-seattle-aquarium-in-elliott-bay-puget-sound-",totalDownloads:1015,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The Seattle Aquarium is centrally located on Elliott Bay in Puget Sound, built on a pier along the central waterfront in Seattle, WA, USA. The Seattle Aquarium Water Quality Laboratory regularly measures water quality metrics on incoming saltwater pumped directly from Elliott Bay for use in the animal exhibits. This study provides a descriptive temporal analysis of variability in the incoming saltwater conducted from 2007 through 2016. Parameters measured on a weekly basis include ammonia (NH3), nitrite (NO2), pH and fecal coliform bacteria. Ammonia mean throughout the dataset was 0.02 mg/l (SE ± 0.0005), with clear seasonal trends of higher ammonia levels during the summer months (May, June and July) annually. Nitrite mean was 0.01 mg/l (SE ± 0.002), with clear seasonal trends of this nutrient with bi-annual peaks in spring and fall (May and September). Saltwater pH mean was 7.81 (SE ± 0.004), trending lower in winter and spring and higher in summer and fall. Fecal coliform bacteria mean over the 10-year period was 20 colony-forming units (CFU) per 100 ml of water. Overall, Elliott Bay water quality remained relatively stable from 2007 to 2016, and if remains unchanged, will continue to be a reliable source of saltwater with known water quality parameters for use in animal exhibits in the Seattle Aquarium.",signatures:"Amy Y. Olsen, Angela Smith and Shawn Larson",downloadPdfUrl:"/chapter/pdf-download/57325",previewPdfUrl:"/chapter/pdf-preview/57325",authors:[{id:"96539",title:"Dr.",name:"Shawn",surname:"Larson",slug:"shawn-larson",fullName:"Shawn Larson"},{id:"212112",title:"Ms.",name:"Amy Y.",surname:"Green",slug:"amy-y.-green",fullName:"Amy Y. Green"},{id:"212113",title:"MSc.",name:"Angela",surname:"Smith",slug:"angela-smith",fullName:"Angela Smith"}],corrections:null},{id:"57396",title:"Challenges and Treatment of Microplastics in Water",doi:"10.5772/intechopen.71494",slug:"challenges-and-treatment-of-microplastics-in-water",totalDownloads:3118,totalCrossrefCites:10,totalDimensionsCites:23,hasAltmetrics:0,abstract:"Microplastics are particularly problematic and could pose big treatment. challenges. In today’s world, plastic is an essential raw material. Since their invention in the 1930s, plastics have become ubiquitous in the manufacture of everyday products. Part of the problem stems from the fact that it can be difficult to pinpoint the exact source of the microplastics because of their relatively fragmented nature, small size, and a wide range of potential sources. Microplastics have become a threat to the environment, a concern reflected by sites with unusually high concentrations and a possibility of even greater concentrations in the future. Consequently, the use and subsequent release of microplastics must be drastically reduced as part of a global initiative even prior to the availability of research studies outlining the long-term risks involved. This chapter will interrogate key sources of microplastics, assess their capacity to problematize water resources in urban environments, as well as offer an analysis of its effects on the environment and some of the methodologies that can be applied to control it.",signatures:"Heloisa Westphalen and Amira Abdelrasoul",downloadPdfUrl:"/chapter/pdf-download/57396",previewPdfUrl:"/chapter/pdf-preview/57396",authors:[{id:"151521",title:"Dr.",name:"Amira",surname:"Abdelrasoul",slug:"amira-abdelrasoul",fullName:"Amira Abdelrasoul"},{id:"214401",title:"B.Sc.",name:"Heloisa",surname:"Westphalen",slug:"heloisa-westphalen",fullName:"Heloisa Westphalen"}],corrections:null},{id:"59475",title:"Territorial Integration of Water Management in the City",doi:"10.5772/intechopen.72876",slug:"territorial-integration-of-water-management-in-the-city",totalDownloads:1200,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"This chapter addresses the need for an integrated approach of water management and governance in the urban areas. Water is understood as a natural and social common good, and the relations between different uses and current management practices are analyzed. This approach needs otherwise to influence not only the technical and social spheres but also the policy one. Therefore, a policy effective integration of the comprehensive and interdisciplinary understanding of water problems is advocated and proposed under the concept of integrated urban water policy (IUWP). The final objective is a contribution to an adequate conceptual and operational framework that enables a better and more effective understanding of the multiple dimensions and complexity of integrated management of water uses, in coherent relation with land use planning.",signatures:"Susana Neto",downloadPdfUrl:"/chapter/pdf-download/59475",previewPdfUrl:"/chapter/pdf-preview/59475",authors:[{id:"213757",title:"Dr.",name:"Susana",surname:"Neto",slug:"susana-neto",fullName:"Susana Neto"}],corrections:null},{id:"57053",title:"Urban Development with the Constraint of Water Resources: A Case Study of Gansu Section of Western Longhai-Lanxin Economic Zone",doi:"10.5772/intechopen.70850",slug:"urban-development-with-the-constraint-of-water-resources-a-case-study-of-gansu-section-of-western-lo",totalDownloads:1319,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Water is the essential resource for urban development of Gansu section of West Longhai-Lanxin economic zone, which is not only the “Golden Development Line” of Gansu province but also the significant component of the new Silk Road within China. Based on more than 2000 data points reflecting various meaningful aspects of urban systems and water resource systems, and using a quantitative measurement model and ArcGIS, this study aimed at discussing the temporal-spatial variations of water resources constraint on urbanization in the Gansu section. From 1989 to 2007, the water resources constraint intensities (WRCIs) of Gansu section and its nine cities have been generally decreasing, albeit with much fluctuation, and the decrease has been more rapid since 2000, with Lanzhou and Jinchang as the most representative cities. From the perspective of water resource constraint on urbanization, the research on urbanization process of Gansu section is not only necessary for the shaping of an independent theoretical system on relationship between water resource and urbanization, but also has very crucial practical significance for promoting construction of resource-saving and environment-friendly cities in Gansu section, arid and semi-arid areas as well as for promoting harmonious regional development.",signatures:"Gao Xiang",downloadPdfUrl:"/chapter/pdf-download/57053",previewPdfUrl:"/chapter/pdf-preview/57053",authors:[{id:"208744",title:"Dr.",name:"Xiang",surname:"Gao",slug:"xiang-gao",fullName:"Xiang Gao"},{id:"208983",title:"Dr.",name:"Tengfei",surname:"Yu",slug:"tengfei-yu",fullName:"Tengfei Yu"}],corrections:null},{id:"57557",title:"Sentinel-1 Satellite Data as a Tool for Monitoring Inundation Areas near Urban Areas in the Mexican Tropical Wet",doi:"10.5772/intechopen.71395",slug:"sentinel-1-satellite-data-as-a-tool-for-monitoring-inundation-areas-near-urban-areas-in-the-mexican-",totalDownloads:1309,totalCrossrefCites:0,totalDimensionsCites:3,hasAltmetrics:0,abstract:"This work shows advances in the field of water body monitoring with radar images. Particularly, a monitoring procedure is developed to define the extension and frequency of inundation for continental waters of the Grijalva-Usumacinta basin, in the state of Tabasco, Mexico. This is a region located in the Mexican tropical wet and under its meteorological conditions, radar technology can be used to characterize monthly inundation frequency. The identification of water bodies were obtained by processing images at a monthly intervals captured by Sentinel-1A during 2015 having kappa indices and overall accuracy higher than 0.9. The chapter describes the seasonal variability of these water bodies, and at the same time, the relationship with human settlements located in their neighborhood. To do this, a proximity analysis was carried out to emphasize the importance of spatial-temporal studies of superficial water bodies, linked to an urban and a rural area. This information is useful to investigate changes in the ecosystem, as well as risks to human settlements, and as a contribution for a comprehensive management of hydric resources.",signatures:"Alejandra A. López-Caloca, Felipe Omar Tapia-Silva and Guadalupe\nRivera",downloadPdfUrl:"/chapter/pdf-download/57557",previewPdfUrl:"/chapter/pdf-preview/57557",authors:[{id:"19577",title:"Dr.",name:"Alejandra",surname:"López-Caloca",slug:"alejandra-lopez-caloca",fullName:"Alejandra López-Caloca"},{id:"208835",title:"BSc.",name:"Guadalupe",surname:"Rivera",slug:"guadalupe-rivera",fullName:"Guadalupe Rivera"},{id:"208836",title:"Dr.",name:"Felipe Omar",surname:"Tapia-Silva",slug:"felipe-omar-tapia-silva",fullName:"Felipe Omar Tapia-Silva"}],corrections:null},{id:"57627",title:"Identifying Changes in Trends of Summer Air Temperatures of the USA High Plains",doi:"10.5772/intechopen.71788",slug:"identifying-changes-in-trends-of-summer-air-temperatures-of-the-usa-high-plains",totalDownloads:1107,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Change in climate variables, especially air temperature, can substantially impact water availability, use, management, allocation, and projections for rural and urban applications. This study presents analyses for detecting summer air temperature change by investigating trends of two separate climate-periods in the USA High Plains. Two trend periods, the reference period (1895–1930) and the warming period (1971–2006), were investigated using parametric and nonparametric methods. During the reference period, minimum air temperature (Tmin) was statistically stationary at a nonsignificant increasing rate of 0.02°C/year. However, from early 1970s, Tmin increased at a significant rate of 0.02°C/year. The maximum air temperature (Tmax) had a weaker warming signal than Tmin during the reference period. During the warming period, Tmax had a cooling trend at a nonsignificant rate of −0.004°C/year. About 22% of the High Plains had significant warming trends before 1930. Compared to the summers before 1930, the summer temperatures of the High Palins since the 1970s increased, on average, by 0.86°C. Overall, parametric methods lead to the conclusion that 50% of the study area experienced a significant warming trend in Tmin. In comparison, nonparametric methods indicated that 94% of the study area experienced a warming trend. Overall, in recent decades, summer average temperatures in the High Plains have been warming as compared to the early twentieth-century decades, and the warming is most likely driven primarily by increasing nighttime Tmin.",signatures:"Denis Mutiibwa, Ayse Kilic and Suat Irmak",downloadPdfUrl:"/chapter/pdf-download/57627",previewPdfUrl:"/chapter/pdf-preview/57627",authors:[{id:"42454",title:"Prof.",name:"Suat",surname:"Irmak",slug:"suat-irmak",fullName:"Suat Irmak"},{id:"207174",title:"Dr.",name:"Denis",surname:"Mutiibwa",slug:"denis-mutiibwa",fullName:"Denis Mutiibwa"},{id:"207175",title:"Prof.",name:"Ayse",surname:"Kilic",slug:"ayse-kilic",fullName:"Ayse Kilic"}],corrections:null},{id:"57345",title:"Safe Drinking Water: Concepts, Benefits, Principles and Standards",doi:"10.5772/intechopen.71352",slug:"safe-drinking-water-concepts-benefits-principles-and-standards",totalDownloads:6129,totalCrossrefCites:11,totalDimensionsCites:23,hasAltmetrics:0,abstract:"Water is connected to every forms of life on earth. As a criteria, an adequate, reliable, clean, accessible, acceptable and safe drinking water supply has to be available for various users. The United Nation (UN) and other countries declared access to safe drinking water as a fundamental human right, and an essential step towards improving living standards. Access to water was one of the main goal of Millinium Development Goals (UN-MDGs) and it is also one of the main goal of the Sustainable Development Goals (SDGs). The UN-SDG goal 6 states that “Water sustains life, but safe clean drinking water defines civilization”. Despite these facts, there are inequalities in access to safe drinking water in the world. In some countries, sufficient freshwater is not available (physical scarcity); while in other countries, abundant freshwater is available, but it is expensive to use (economic scarcity). The other challenge is the increasing population of the world at an alarming rate, while the available freshwater resources almost remains constant. This chapter presents aspects of safe drinking water - background information, definition of water safety and access, benefits, principles and regulations, factors challenging the sustainable water supply and water quality standards and parameters.",signatures:"Megersa Olumana Dinka",downloadPdfUrl:"/chapter/pdf-download/57345",previewPdfUrl:"/chapter/pdf-preview/57345",authors:[{id:"206964",title:"Dr.",name:"Megersa Olumana",surname:"Dinka",slug:"megersa-olumana-dinka",fullName:"Megersa Olumana Dinka"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"911",title:"Water Stress",subtitle:null,isOpenForSubmission:!1,hash:"639300ffd325d217a7b6ec2261ff26e0",slug:"water-stress",bookSignature:"Ismail Md. Mofizur Rahman and Hiroshi Hasegawa",coverURL:"https://cdn.intechopen.com/books/images_new/911.jpg",editedByType:"Edited by",editors:[{id:"110740",title:"Dr.",name:"Ismail M.M.",surname:"Rahman",slug:"ismail-m.m.-rahman",fullName:"Ismail M.M. 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Perspectives and Application",subtitle:null,reviewType:"peer-reviewed",abstract:"\r\n\tWireless power transfer is the process of transmitting electrical energy using electromagnetic waves. With the advent of wireless power transfer, energy can therefore be collected without the physical need of connecting a device to a power source. This technology certainly provides great convenience to mankind, since the hassle of using wires to connect a load to the power grid can be saved. The advantage of wireless power transfer is particularly evident in desolated rural areas where electricity is a scarce luxury to the residents. In general, electrical energy can be transmitted wireless via near-field and far-field mechanisms. The near-field or non-radiative method employs inductive coupling between coils of wires or capacitive coupling between metallic electrodes to realize the purpose of energy charging. The far-field or radiative method, on the other hand, transfers electrical energy via wave radiation. The concept is somewhat similar to that of a wireless telecommunication device. Instead of transmitting and receiving information, however, the far-field approach makes use of antennas to harvest energy. Despite the prevailing advancement of wireless power transfer technology, there are still open issues yet to be solved.
\r\n\r\n\tThis book will give a detailed elucidation of some of the latest technologies used for wireless power transfer. The challenges faced by researchers working in this field and ways to overcome them are also discussed.
\r\n\t
We present a general form of scalar conservation laws with further properties including some basic models and provide examples of computational methods for them. The equations described by
in one dimension are known as scalar conservation laws where
We start by investigating the relation of the equations in gas dynamics with conservation laws. We take into account the equation of conservation of mass in one dimension. The density and the velocity are assumed to be constant in the tube where
The last equation is called integral form of conservation law. Integrating this expression in time from
Using the fundamental theorem of calculus after reduction of Eq. (3), it follows that
As a result, we get
Here the end points of the integrations are arbitrary; that is, for any
which is said to be the differential form of the conservation law.
A general solution to a quasilinear partial differential equation of the form
where
By applying a parametrization of
In addition to these equations, if an initial condition
Observe that the scalar conservation law (1) is a particular example of Eq. (7) if we assign
This means, the quantity
We consider the initial value problem
where the initial data is assumed to be continuously differentiable, that is,
where we define characteristic curves of Eq. (12) to be the solution of
with
Along this characteristic curve,
is satisfied, that is,
Hence we can define smooth solutions by
The basic example of the scalar conservation law is the linear advection equation. It can be obtained by setting
is a linear advection equation. Similar to Eqs. (11) and (12), an initial value problem for linear advection equation is described by
Applying the method of characteristics, it follows that
where
Here
Burgers’ equation is the simplest nonlinear partial differential equation and is the one of the most common models used in the scalar conservation laws and fluid dynamics. The classical Burgers’ equation is described by
where
where
Plugging these terms in Eq. (21), we get
Taking integration with respect to
Rewriting Eq. (25) by
it follows that
As a result the explicit form of traveling wave solution of Eq. (21) becomes
where
Whenever
Observe that
Recall that the characteristic speed
and differentiating equation (30) with respect to
Thus, substituting Eqs. (31) and (32) in (29), we can recover the inviscid Burgers’ equation. Consequently, the relations (31) and (32) imply that the solutions of Eq. (1) and particularly of Eq. (29) depend on the initial value
Let the constants
is a simple example of discontinuous solution of the conservation law (11). If
where
For the initial value
For the initial value
A rarefaction wave is a strong solution which is a union of characteristic lines. A rarefaction fan is a collection of rarefaction waves. These waves are constant on the characteristic line
If, for instance, f is convex, then the rarefaction waves are increasing. If we consider again the inviscid Burgers’ equation with the initial values, then the region without characteristics in Figure 2 will be covered by rarefaction solution which is described by
An illustration of rarefaction waves and rarefaction fan in Eq. (36) is given in Figure 3.
Rarefaction fan.
Weak solutions occur whenever there is no smooth (classical) solution. These solutions may not be differentiable or even not continuous. Considering
Putting the initial condition
Observe that there are no more derivatives of
The Riemann problem is a Cauchy problem with a particular initial value which consists a conservation law together with piecewise constant data having a single discontinuity. We consider the Riemann problem for a convex flux described by
The solution is a set of shock and rarefaction waves depending on the relation between
Case 1:
is a shock wave satisfying the shock speed
Case 2: (
A jump discontinuity along the characteristic line is controlled by the Rankine-Hugoniot jump condition. Integrating the scalar conservation law (1) in
Suppose that there is a discontinuity at the point
By the fundamental theorem of calculus, the relations (41) and (42) yield
Taking the limit whenever
The relation (44) is said to be the Rankine-Hugoniot jump condition. Geometrical meaning of the Rankine-Hugoniot jump condition is that the shock speed is the slope of the secant line through the points
Entropy and entropy flux are defined for attaining physically meaningful solutions. If
is satisfied for continuously differentiable functions
which looks like to the scalar conservation law (1). Indeed, if we multiply Eq. (1) by
It follows that Eqs. (46) and (47) are equivalent with
holds for all convex entropy pairs
Weak solutions to conservation laws may contain discontinuities as a result of a discontinuity in the initial data or of characteristics that cross each other or because of the jump conditions which are satisfied across the discontinuities. Although the Rankine-Hugoniot jump condition is satisfied, the uniqueness of the solution may always not be guaranteed. In order to eliminate the nonphysical solutions among the weak solutions, we need an additional condition, so-called entropy condition. It is described by the following: A discontinuity propagating with the characteristic speed
The inviscid Burgers’ equation and Eq. (49) have exactly the same smooth solutions. But their weak solutions are different. A shock traveling speed for the inviscid Burgers’ equation is
Applying the method of characteristics for
Next if we integrate Eq. (51) with respect to
where
which satisfies both the jump condition and the entropy condition as
For initial value
By the method of characteristics, we obtain a solution
which is a classical (strong) solution on both sides of the characteristic line
which satisfies both jump and entropy conditions. Here we can observe the rarefaction fan arising on the interval
For initial value
The equation of fluid dynamics can be represented in Eulerian and Lagrangian forms. Eulerian coordinates are related to the coordinates of a fixed observer. On the other hand, Lagrangian coordinates are in usual related to the local flow velocity. That is, due to the velocity taking different values in different parts of the fluid, the change of coordinates is different from one point to another one.
The equations of gas dynamics in Eulerian coordinates can be written in the following conservative forms:
where we ignored the heat conduction. If we denote
then Eq. (57) can be written by
where
If we do not neglect the heat conduction, then the
where
where
which are real, and the eigenvectors are linearly independent implying that the Euler equations for perfect gases are hyperbolic.
Using the results in the previous part, the Rankine-Hugoniot jump conditions for the Euler system will be of the form
where the indices
The Riemann problem for the one-dimensional Euler equation (57) is represented by
The reader is addressed to the references [18, 24] for further details.
We aim to transform the equations of gas dynamics (57) given in the Eulerian coordinates into the Lagrangian coordinates for one-dimensional case. We start denoting by
We set the following change of coordinates from Euler coordinates to Lagrange coordinates for space and time as
It follows that
which gives
It follows by some algebraic manipulations that the gas dynamic equations become
In order to derive a more convenient form of the system (69), we derive firstly the equation of conservation of mass:
where
which yields
Hence the second and third equations of Eq. (69) become
Moreover, we define a mass variable
Finally, using Eqs. (69) and (73), the Euler system (57) can be written in Lagrangian coordinates with the mass variable in the form
where
which is strictly hyperbolic. This can be verified by checking the Jacobian matrix of the flux calculated with respect to the variables
with
In fact there are different versions of the gas dynamics in Lagrangian coordinates. In this part we followed the approaches stated in [9, 10, 12]. For further details we cite these works with references therein.
Similarly as in the Euler system, the Rankine-Hugoniot jump conditions for the Lagrangian system (79) are of the form
where
is a one-dimensional isentropic gas dynamics in Lagrangian coordinates which is also known as
The system (79) is equivalent to
where
has two real distinct eigenvalues
The Godunov scheme deals with solving the Riemann problem forward in time for each grid cell and then taking the mean value over these cells. The Riemann problem is solved per mesh point at each time step iteratively. If there are no strong shock discontinuities, this process may cost much and will not be effective. To get rid of such a situation, we establish approximate Riemann solvers that are easier to implement and also low cost to use. Eulerian and Lagrangian Godunov schemes are current Godunov scheme in literature. Both have advantages and disadvantages depending on the structure of the problem. A brief comparison of the method for these two approaches is presented in the last part of the chapter. In this work we will not go further in numerical examples and details of these methods; instead, we aim to present a general form of Godunov schemes for gas dynamics in Eulerian and Lagrangian coordinate. Before introducing these, we present a first-order Godunov scheme for scalar conservation laws.
Consider the scalar conservation law (1). Godunov scheme is a numerical scheme which takes advantage of analytical solutions of the Riemann problem for the conservation law (1). The numerical flux functions are evaluated at the spatial steps
respectively. These two solutions to the Riemann problem will be the numerical solution
Proceeding this process, we define the solution
Dividing both parts by
Thus, Godunov method is a conservative numerical scheme. It can be restated in an alternative form. Assigning the constant value of
Therefore, a first-order Godunov method takes the form
Here the constant value of
The Godunov method is
for each
where
For numerical illustration of Godunov schemes, we cite the articles [14, 20, 27].
We consider Eq. (59) with (60). The eigenvalues of
Consider the initial condition for a quantity
The eigenvalues satisfy
Then Godunov scheme for the Lagrangian coordinates takes the form
where
If we now consider the moving coordinates, Godunov scheme can also be derived equivalently by the following. Setting
Next we deduce
by a simple induction process. Hence the Lagrangian Godunov schemes become
with
Notice that the Lagrangian Godunov schemes can be reformulated as a finite volume method. Equation (100) can be written in conservative form:
If we integrate these equations on
Here we omit the dependency of
Moreover, if
provided
In the literature there are two types of Godunov schemes: the Eulerian and Lagrangian. To compare one with the other, both have advantages and disadvantages. These are briefly listed in the following:
It is more nature; that is the properties of a flow field are described as functions of the coordinates which are in the natural physical space and time. The flow is determined by examining the behavior of the functions. Eulerian coordinates correspond to the coordinates of a fixed observer. This approach is ease of implementation and computation. The computational grids derived from the geometry constraints are generated in advance. The computational cells are fixed in space, and the fluid particles move across the cell interfaces. Since the Eulerian schemes consider the implementation at the nodes of a fixed grid, this may lead to spurious oscillations for the problems like diffusion-dominated transport equations. By adding artificial diffusion, one can get rid of these oscillations; however the nature of the problem may differ from the original one. Besides, refining the grids may also lead to remove numerical oscillations, but this process may augment the computation cost. Besides, while refining the grids, it may cause restriction of the size of time step which is limited by CFL condition. This restriction does not occur in Lagrangian case.
It is based on the notion of mass coordinate denoted by
Apart from the two main approaches, there is another method which is a combination of both, so-called Eulerian-Lagrangian methods. It combines the advantages and eliminates disadvantages of both approaches to get a more efficient method. For further details we address the reader to the reference in the next part.
We have tried to present only the theoretical aspects of scalar conservation laws with some basic models and provide some examples of computational methods for the scalar models. There are plenty of contributors to the subject; however, we just cite some important of these and the references therein. Scalar conservation laws are thoroughly studied in particular in [12]; for a more general introduction including systems, see [13, 15, 18, 19, 22] and the references therein. There are some important works related to the concept of entropy provided by [7, 15, 16]. A more precise study of the shock and rarefaction waves can be found in [23]. A simple analysis for inviscid Burgers’ equation is done by [21]. The readers who are deeply interested in systems of conservation laws and the Riemann problem should see [8, 13, 15, 22, 24]. A well-ordered work of the propagation and the interaction of nonlinear waves are provided by [26]. We refer the reader to the papers [1, 17] for the theory of hyperbolic conservation laws on spacetime geometries and finite volume analysis with different aspects. A widely introductory material for finite difference and finite volume schemes to scalar conservation laws can be found in [18]. In this chapter we have studied the one-dimensional gas dynamics on the Eulerian and Lagrangian coordinates. For the detail on the Lagrangian conservation laws, we refer [10]; moreover for both Eulerian and Lagrangian conservation laws, we cite [11]. The proof of the equivalency of the Euler and Lagrangian equations for weak solutions is given in [25]. There are several numerical works for Lagrangian approach; some of the basic works on Lagrangian schemes are given in [2, 3, 4, 5, 6]. We refer the reader to the book [7] for a detailed analysis of the mathematical standpoint of compressible flows. Moreover Godunov-type schemes are precisely analyzed in [14, 27]; whereas, Lagrangian Godunov schemes can be found in [2, 12, 20]. As a last word, we must cite [9] as a recent and more general book consisting of scalar and system approaches of both Eulerian and Lagrangian conservation laws with theoretical and numerical parts which can be a basic source for the curious readers.
Clinical nutrition refers to practices for supplying nutrients to individuals when oral administration is inadvisable, insufficient, or impossible [1]. These are essential to maintain the function of vital organs and systems, minimizing the effects of food deprivation and avoiding nutritional deficiencies [2]. In general, these techniques are divided between enteral nutrition, in which liquid diet is directly administered into the gastric or intestinal cavity, and parenteral nutrition, in which nutritional solutions are delivered intravenously (Figure 1; [3]).
\nEnteral (nasogastric, nasoduodenal, nasojejunal, gastrostomy, jejunostomy) and parenteral nutrition.
Most clinical nutrition specialists report that enteral nutrition has multiple advantages over parental nutrition and should be selected whenever the gastrointestinal tract can be used [3, 4, 5, 6, 7, 8]. Parenteral nutrition is more expensive [6, 7, 9] and is usually more invasive in comparison to enteral nutrition, exposing patients to greater risks [10]. Notably, there are important clinical reasons for preferring the enteral administration route because of the association of parenteral nutrition with severe complications, including thromboembolism, severe metabolic fluctuations, hyper- or hypoglycemia, hyperlipidemia, blood electrolyte abnormalities, infectious complications [2, 7, 11, 12], and, more controversially [13], a greater risk of “bacterial translocation” [12, 14, 15, 16, 17].
\nBacterial translocation takes place when bacteria usually confined to the digestive tract penetrate the intestinal mucosa and invade the lymphatic system, blood system, and numerous internal organs [16, 17, 18]. This event has been described as one of the main causes of septicemia and as a risk factor for the onset and progression of multiple organ failure, characterized by the uncontrolled systemic inflammation of internal organs [14, 16, 18, 19, 20]. The main factors proposed as possible triggers for bacterial translocation include intestinal mucosal barrier break (increased mucosa permeability), intestinal microflora alteration (bacterial overgrowth), and immune system impairment [5, 17, 18, 21]. These changes are associated with parenteral but not enteral nutrition [21, 22, 23, 24].
\nUnder normal conditions, the gastrointestinal mucosa acts as an effective barrier against the migration of microorganisms into the systemic circulation [16, 21, 25]. The integrity of this barrier is determined by the renewal of epithelial cells that compose it and by the number and type of bacteria that it contains [20, 25, 26]. A key stimulus for mucosal cell proliferation and the maintenance of bacterial homeostasis appears to be the presence and availability of nutrients in the intestinal lumen [4, 5, 6, 16, 24, 25, 26, 27]. The food itself and the hormones released in its presence exert trophic effects on mucosa throughout the gastrointestinal system, from the stomach, small intestine, and colon to the gallbladder and pancreas [5, 24, 25, 26]. Both stimuli preserve the intestinal flora [5, 6, 20, 21, 22], which in turn critically modulate the immune response by producing the enzymes needed to release immunostimulant nutrients and by activating the secretion of cytokine-like molecules known as bacteriocins [23, 25, 28].
\nHence, mucosa atrophy is favored when the gastrointestinal system is not used, as in patients receiving parenteral nutrition. This increases the risk of septic complications [12, 20, 25] and compromises intestinal immunocompetence, because the expression and induction of specific immune responses critically depend on the local microenvironment [20, 25, 28]. These problems are less frequently encountered in patients receiving enteral nutrition [9, 12, 20, 21].
\nFor these reasons, enteral (rather than parenteral) nutrition is recommended in a wide range of clinical situations, including organ transplantation [11], cancer [29], pancreatitis [3, 30], Crohn’s disease [31], intestinal resection or inflammation [5], critical disease [3, 6, 7, 9], and the postoperative period [3, 8, 11, 23]. It is also preferred for premature or low-birth-weight infants [12, 32], for the elderly, for neurological patients [29, 33, 34, 35], for patients with anorexia nervosa [29], and for those with AIDS [36]. Nevertheless, enteral nutrition is not free of drawbacks, as discussed below [1, 22].
\nThere is a consensus among health-care professionals that the nutritional status of patients is lower in those receiving enteral nutrition than in those fed orally. Enteral feeding has been associated with several disorders, although it is sometimes difficult to establish whether they are caused by the disease, the specific diet, or by the food administration route [1].
\nHowever, regardless of their disease, patients on enteral nutrition often show a series of “secondary” symptoms that can be described as gastrointestinal tract reactions to diet administration, including: pain, discomfort, gastric residual volume, delayed gastric emptying, abdominal bloating and cramps, nausea/vomiting, diarrhea [1, 4, 8, 9, 12, 20, 22, 32, 33, 34, 35, 36, 37, 38, 39], metabolic disorders [1, 12], and, when the enteral nutrition is longer term, ulcers and major weight loss [33, 34]. In addition, some patients are unable to tolerate enteral nutrition [9, 22], especially pediatric patients [38, 39].
\nThe causes of these problems have not been fully elucidated, although some psychobiological studies, mainly in animals, have suggested that they may in part result from the entry of food into the digestive tract in “nonphysiological” conditions [40, 41]. The absence of oral stimulation means that the digestive system is not prepared to receive the food (with the appropriate endocrine and exocrine secretions or motor activity changes, etc.), hampering the optimal digestion, absorption, and utilization of the nutrients (see below).
\nIn experimental studies, enteral nutrition is known as intragastric or intraintestinal feeding and also appears to be accompanied by numerous disorders that affect the digestion, absorption, and metabolism of nutrients. In these feeding modalities, meals are directly delivered to the gastric cavity (intragastric feeding) or lower segments of the digestive tube, such as the duodenum or jejune (intraintestinal feeding), generally using a permanently implanted catheter. A physiological variable or function is then studied and compared with results obtained for oral feeding or for sham feeding, in which the food is orally ingested but extracted
One of the first authors to document alterations in animals caused by intragastric feeding was the Russian scientist Ivan Pavlov [42], whose studies masterfully demonstrated the marked importance of the passage of food through oropharyngeal systems for its subsequent digestion [43, 44]. This oropharyngeal stimulation, designated “psychic reflex” by Pavlov, is now known as the cephalic phase of digestion, which comprises a set of autonomic and endocrinal responses to stimulation by the food of sensory perceptive systems in the head and particularly in the oropharyngeal cavity. Nevertheless, although these cephalic responses are preferentially initiated by contact with the food, they can also be effectively elicited just by seeing or anticipating it or by thoughts or any learned cues associated with it [40, 42, 44].
\nThe digestive events triggered by cephalic stimulation are mediated by vagal parasympathetic efferents except for salivary secretions, which are partly controlled by sympathetic and nonvagal parasympathetic fibers. These vagal efferents, which are distributed throughout the digestive tube and associated digestive organs (liver, pancreas, and gallbladder), largely originate in the dorsal motor nucleus of the vagus (DMV), which is localized in the caudal medulla oblongata close to the floor of the fourth ventricle and is closely related to the nucleus of the solitary tract, the main structure receiving visceral signals from the digestive system [40, 41, 42, 43, 44].
\nDMV activity is directly or indirectly modulated by centers at upper levels of the nervous system that are responsible for the changes in digestive function that take place during the cephalic phase of digestion. This descending control of the DMV has been reported for such structures as the insular cortex, medial prefrontal cortex, central nucleus of the amygdala, bed nucleus of the stria terminalis, tegmental ventral area, and nucleus accumbens. Many of these signals reach the DMV through relays in hypothalamic regions (posterior hypothalamus and paraventricular nucleus) and brainstem regions (e.g., periaqueductal gray matter or parabrachial nucleus) [40, 44, 45, 46, 47].
\nPavlov reported that when food was directly introduced into the stomach, the secretion of gastric juices was delayed and scant, with weak digestive power, contrasting with the rapid and abundant cascade of gastric secretions observed when the same nutrients passed through the oropharyngeal cavity after their real or sham intake. He concluded that the low gastric juice secretion in enteral nutrition delays and considerably prolongs digestion [42].
\nThe absence of oropharyngeal stimulation also indirectly delays other digestive secretions. It was reported by Pavlov that intragastrically administered food is not accompanied by salivary secretions, whose arrival in the stomach cavity stimulates the release of gastric juices [42]. It has also been demonstrated that the digestion of carbohydrates and fats that starts in the mouth through the action of salivary amylase and lipase continues in the stomach [48, 49, 50]. Hence, the absence of saliva delays gastric secretion and hampers the digestion of some nutrients. There is also an indirect effect on the release of pancreatic juices, whose secretion is determined by the level of hydrochloric acid in the stomach [42].
\nAbsence of the cephalic phase impacts on digestion-related substances throughout the digestive system, from the mouth or stomach (e.g., salivary enzymes, hydrochloric acid, gastrin, pepsinogen, immunoglobulins, etc.), as mentioned above, to the small intestine (bicarbonate or digestive enzymes), liver, or pancreas (numerous hormones) (for review, see references [40, 44]). Many secretions triggered by cephalic stimulation are also specific and adapted to the nature of the food [42, 51, 52, 53, 54, 55, 56]. In other words, food components appear to be identified before they reach the stomach, allowing the digestive system to be specifically prepared for their transformation and utilization [40, 57].
\nRemoval of the cephalic phase affects not only endocrine and exocrine secretions but also gastrointestinal motor activity, with an anticipatory increase in cephalic stimulation [58, 59, 60, 61]. The intragastric feeding of experimental animals has also been found to markedly accelerate the outflow of gastric contents into the duodenum [62, 63, 64], which might be responsible for the discomfort experienced by patients with “dumping syndrome” [62]. This syndrome is observed in humans who have undergone abdominal vagotomy and is characterized by the rapid emptying of gastric contents into the duodenum, producing nausea and epigastric pain [65]. In this regard, the intraintestinal administration of nutrients (fats) was found to significantly damage the intestinal mucosa [63, 66].
\nDisorders induced by the absence of oropharyngeal stimulation extend to postabsorptive stages [54, 57, 62, 64, 67, 68, 69, 70]. In human studies, glucose intolerance (increased blood levels) and reduced blood glucagon levels were observed after intragastric glucose administration, but not when this was accompanied by oral sensory stimulation through modified sham feeding [71]. It has also been demonstrated that lipolysis is slower with intragastric
Responses that are affected by the absence of cephalic stimulation can be observed in other levels of the digestive system and beyond, including postprandial thermogenesis, anticipatory rise in heart rate, increased respiratory rate in response to eating, and changes in the transport and intestinal absorption of nutrients and in bile flow and secretin release, among others [49, 72, 73, 74, 75].
\nTaken together, published studies confirm that the cephalic phase not only optimizes food digestion but also intervenes in processes related to nutrient absorption and metabolism. Many of these effects may be secondary to the release of gastrointestinal hormones, whose secretion is stimulated by the anticipation and presence of food in the oropharyngeal cavity [76, 77, 78, 79].
\nAccording to the above-reported studies, intragastric or intraintestinal feeding means that the digestive system is not prepared to receive, digest, process, or even appropriately utilize the administered nutrients. They would arrive in the system under nonphysiological, negative conditions, which may in part account for the digestive problems that can often make enteral nutrition nonviable.
\nTaste learning is one of the behavioral procedures used by scientists to determine whether individuals perceive the food reaching the digestive system as positive or negative. In these learning tasks, two nonnutritional flavored solutions of water are offered, with the intragastric/intraintestinal administration of a nutritional stimulus being associated with one solution and of an innocuous, nonnutritional stimulus (e.g., physiological saline) with the other. The preference of animals is determined after multiple sessions pairing the taste and visceral stimuli [80, 81, 82, 83].
\nStudies using this technique have demonstrated that the direct administration of complex food into the gastric cavity is a powerful way to establish flavor-conditioned aversions [66, 80, 84, 85, 86]. Thus, when rats were subjected to a discriminative flavor learning task using whole milk as visceral stimulus, they preferred the flavor associated with physiological saline and strongly rejected the flavor associated with the food, even after a 22-h food deprivation period [80, 84, 85, 86]. Similar results were observed with intraintestinal feeding, finding that association of the intraduodenal administration of fats or glucose with the oral intake of saccharose or water produced a strong rejection of both in subsequent presentations [66, 80, 81, 86, 87, 88].
\nResults obtained with the enteral administration of natural food markedly contrast with those obtained for the intragastric administration of food subjected to cephalic processing (aspirated from the stomachs of donor subjects shortly after its oral consumption). Unlike observations with natural food, the animals developed a strong preference for the taste stimulus associated with the administration of “predigested” food and rejected the stimulus associated with physiological saline [80, 81, 86, 87, 88]. Hence, enterally administered foods are experienced as rewarding/positive when they have undergone oropharyngeal processing, and assistance of the cephalic phase appears to adapt enteral diets more closely to digestive physiology. According to these data, the digestive system also seems perfectly prepared for the rapid assessment of the suitability of foods and for the transmission of this information to the central nervous system.
\nResults of research in animals have prompted numerous clinical studies. Although enteral nutrition was not a routine clinical practice until the 1960s, food had long been administered
One of the most famous studies in this field was published by Wolf and Wolff and known as “Tom’s case.” In 1895, at the age of 9 years, Tom underwent gastronomy after accidentally eating boiling food and was only able to consume food
In summary, these data indicate that the signals produced by food in the oropharyngeal cavity trigger a cascade of exocrine, endocrine, and motor reactions that prepare the digestive system for the reception, digestion, absorption, and metabolism of the food ingested, allowing feeding to be perceived as a satisfactory or rewarding event. When these signals are missing, a series of noxious consequences can hamper the adequate development of these processes, making the feeding experience negative or “stressful” [40, 41, 44, 62].
\nIt is therefore possible that some of the noxious effects of enteral nutrition can be palliated by administering diets that imitate “cephalic” food in some way. This possibility is currently under investigation in our laboratory.
\nIn general, two distinct procedures can be used to establish flavor learning, designated by our group as concurrent and sequential flavor learning. Two nonnutritional flavored stimuli with their respective intragastric administrations are simultaneously offered during a short time period (usually 7 min) in concurrent learning, whereas the stimuli are presented in alternating sessions in sequential learning (Figure 2). A key difference between these procedures is that animals must detect and process visceral stimuli very quickly to establish an association in concurrent learning, whereas this can be established in a more delayed fashion in sequential learning [82, 93, 88].
\nExperimental procedure followed in concurrent (A) and sequential (B) flavor learning. In the former, two flavored stimuli are presented at the same time; when the animal voluntarily consumes one of these stimuli, it is simultaneously and intragastrically administered with the associated visceral stimulus (e.g., predigested nutrients through an intragastric cannula); when the animal consumes the other stimulus, it is simultaneously and intragastrically administered with the other visceral product (e.g., physiological saline) through a second cannula. The same procedure is followed in sequential learning (B) except that each of the flavored stimuli and their respective intragastric administrations are presented in alternate sessions.
Using these procedures, and with the aim of being able to palliate the negative effects of enteral nutrition in the future, our group has studied the rapid pathway for processing information related to nutritional stimuli present in the gastrointestinal tract (concurrent learning), especially in the case of suitable or rewarding (“cephalic”) foods [81, 87, 88].
\nInformation from the gastrointestinal tract reaches the brain
Neuroanatomical and neurophysiological studies have demonstrated that the gastrointestinal tract receives both vagal and spinal nerve fibers [97], and either may have carried nutritional information to the brain in our studies. However, numerous physiological and behavioral investigations have indicated that spinal visceral afferents are less important in nutrition [98] and appear more related to nociceptive processes [99]. For this reason, we have focused on the vagal system in our experiments on the neural substrates involved in transmitting rewarding visceral information to the central nervous system.
\nVagal afferents are distributed throughout the digestive system (Figure 3) and receive detailed information on the specific nature of the nutrients present in the gastrointestinal lumen
Anatomical pathways and nuclei involved in the rapid detection and processing of nutritional rewarding visceral information (SolG: gelatinous subnucleus of nucleus of solitary tract; LPBe: external lateral parabrachial subnucleus).
In rats, the NTS is a small-sized bilateral structure that ends in a single midline nucleus caudal to the area postrema (AP), one of the main circumventricular organs of the brain (Y-shaped in horizontal plane). Three regions have been differentiated in the anteroposterior dimension of the NTS: a rostral region that extends from the rostral pole of the nucleus to the point where the medial division contacts the fourth ventricle border; an intermediate band that extends from this last point to the caudal end of the AP; and a caudal division wholly occupied by the commissural subnucleus [105, 106, 107]. Most of the subnuclei of the NTS are found in its intermediate region, especially in the medial division (localized medially to the solitary tract, a bundle of fibers that crosses the entire anteroposterior extent of the nucleus) [107].
\nThe NTS is the first relay for a wide range of special and general visceral afferent sensory fibers (oropharyngeal, gastrointestinal, cardiovascular, and respiratory), which are relatively segregated in subnuclei distributed throughout its rostrocaudal dimension. Those originating in the gastrointestinal system largely terminate in subnuclei in the medial division of the intermediate-caudal NTS [105, 106].
\nOur group has investigated the participation of vagal afferents in the rapid transmission of rewarding nutritional information to the brain using capsaicin (8-methyl N-vanillyl-6-nonenamide), the pungent component in red pepper of the genus
We applied capsaicin around the esophagus, selectively lesioning unmyelinated afferents and weakly myelinated fibers [108], which are both largely present in the vagus nerve [109, 110]. We found that information transmission mediated by capsaicin-sensitive vagal afferents is essential in concurrent taste discrimination tasks [87]. Thus, neurochemical interruption of this pathway hampers the establishment of taste preferences induced by the intragastric administration of “cephalic” foods, which is achieved without difficulty by neurologically intact animals.
\nHowever, capsaicin-sensitive afferents are not indispensable for the induction of taste preferences using sequential tasks. In this case, both capsaicin-treated and neurologically intact animals effectively learn the task and show clear preferences for taste stimuli associated with the intragastric administration of predigested nutrients. These results support the idea that information is unlikely to be transmitted to the brain
Anatomical, physiological, and immunohistochemical studies have demonstrated that vagal afferents from the upper gastrointestinal tract project toward the intermediate-caudal region of the NST (Figure 3), a gateway for visceral signal processing [111]. Thus, various subnuclei of the intermediate-caudal region of the NST (NSTic) show c-fos activity after normal food intake [112], after intragastric or intraduodenal nutrient administration [113, 114, 115], and in situations of gastric [116] and intestinal [117] distension, among others. In many of these cases, NSTic activation is abolished by the chemical or surgical lesioning of vagal afferents [114, 118].
\nGiven the time constraints implicit in the concurrent procedure, the digestive segments most likely to be involved in this learning modality (i.e., responsible for initial detection of the visceral stimulus) would be proximal ones (preferentially the stomach and duodenum). Sensory visceral information is known to be organized topographically in the NSTic with relative anatomical segregation [105, 106]. For instance, a high density of gastric vagal afferents is concentrated in the lateral portion of the dorsomedial NST in a cell cluster known as the gelatinous nucleus [105, 106, 107, 111, 119], whereas afferents from the duodenum and other segments of the small intestine are distributed in different areas of the dorsomedial nucleus, especially in more caudal and medial areas of the intermediate region [105, 106, 117].
\nOur group recently demonstrated that the gelatinous subnucleus (SolG) participates in the learning of concurrent taste preferences induced by intragastrically administered “cephalic” foods [88]. It therefore appears that the gelatinous nucleus (SolG), alongside capsaicin-sensitive vagal afferents, may participate in the neural pathway that rapidly processes rewarding nutritional information from the upper gastrointestinal tract. This subnucleus almost exclusively concentrates gastric vagal afferents [106, 113, 117, 119] and is a receptor of fine vagal afferents [120], that is, the type of fibers lesioned by capsaicin [108]. In addition, capsaicin-induced damage of small ganglion cells was found to produce axonal degeneration in the SolG, among other regions [121].
\nThe NSTic in turn relays visceral information from the gut to the lateral division of the pontine parabrachial complex (Figure 3), especially to its lateral external subnucleus.
\nThe parabrachial complex is a grouping of subnuclei that surround the superior cerebellar peduncle along its course through the dorsolateral pons. In rats, the subnuclei localized dorsally to the peduncle constitute its lateral division (LPB) and those localized ventrally the medial division [122]. The external subnucleus (LPBe), localized at the most lateral border and throughout the rostrocaudal dimension of the LPB, concentrates information from both the stomach and duodenum, receiving a large number of the afferents projected from the dorsomedial NTS, including the SolG[107, 122, 123].
\nThese anatomical connections allow modification of LPBe activity by electrical stimulation of the vagus nerve and by the intragastric administration of various nutrients [114, 124, 125]. Moreover, the intragastric application of nutrients induces c-fos expression in intermediate-caudal and dorsomedial NST subnuclei and in the LPBe, among other regions [114, 115]. This dual activation has also been observed after the administration of substances that positively or negatively affect food intake, including pharmacological agents (such as methyl palmoxirate, 2,5-anhydro-D-mannitol, or dexfenfluramine) and various hormones (e.g., cholecystokinin, bombesin, or secretin) [126, 127, 128, 129, 130, 131]. These effects of neuronal activation and/or intake can also be abolished or attenuated by truncal vagotomy or perivagal capsaicin treatment [114, 126, 130, 131, 132, 133, 134].
\nOur laboratory has also addressed the possibility of the LPBe nucleus being part of the rapid processing pathway of rewarding information related to nutrients present in the upper gastrointestinal tract in our laboratory. Unlike neurologically intact animals, LPBe-lesioned animals proved unable to develop taste preferences induced by the intragastric administration of “cephalic or predigested” foods in concurrent taste learning tasks, but both groups were able to learn taste preferences in sequential taste learning tasks [81].
\nWe have also used other procedures to explore the involvement of the LPBe in rewarding processes, including the induction of taste and place preferences by electrical stimulation of this subnucleus [135]. In addition, large lesions of the LPB, including the external subnucleus, appear to reverse aversive effects of the intragastric administration of natural, nonpredigested nutrients, avoiding rejection of the associated taste stimulus and appearing to induce a flavor preference (
Considered together, these data suggest that the rapid processing of visceral information on rewarding nutrition (in upper gastrointestinal segments) is mediated by a neural pathway that originates peripherally in the vagus nerve and includes NSTic regions (e.g., SolG) and the LPBe [81, 87, 88]. In fact, this visceral vagal-NSTic-LPBe information pathway also appears to participate in other physiological processes requiring the rapid transmission of nutritional information. We recently showed that both the vagus nerve [136] and SolG [137] or LPBe [138] are essential in circumstances that require the immediate adjustment of food intake, extracting part of ingested food immediately after ending a meal and finding that approximately the same amount was reingested by neurologically intact animals but a much smaller amount by lesioned animals.
\nThe vagus nerve-NSTic-LPBe pathway also proved essential for the rapid transmission of nonnutritional visceral information. We found that the vagus nerve [83] and NSTic [139] or LPBe [140] are necessary for concurrent taste aversion learning but not for sequential TAL.
\nAccording to the studies presented in this chapter, organisms have at least two complementary neurobiological systems for the detection and processing of nutritional rewarding visceral information: one that depends on the vagus nerve, NSTic, and LPBe, and another that is independent of this pathway. The former appears to participate when rapid information processing is needed and the latter when there are no time constraints.
\nResearch into the biological mechanisms underlying nutritional behavior is exhilarating, both for the simple pleasure of unraveling these complex phenomena and for its potential importance in numerous clinical fields, including artificial nutrition. As shown in our review, enteral nutrition for any reason and of any type is frequently associated with adverse effects whose causes have yet to be fully elucidated. Studies by our group suggest that at least some of these negative effects may result from the absence of the cephalic phase of digestion. Further investigations of the physiology of this nutritional process are needed to support the design of enteral diets better adapted to digestive physiology and the development of pharmacological strategies that counteract its noxious effects.
\nThe authors are grateful to Richard and Layla Davies for their assistance with the English version of this chapter and to Alejandro Navarro for creating Figures.
\nThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
\nOve Odredbe i uvjeti ističu pravila i regulacije u svezi korištenja IntechOpenove stranice www.intechopen.com i svih poddomena u vlasništvu IntechOpena, tvrtke sa sjedištem u 5 Princes Gate Court, London, SW7 2QJ, Ujedinjeno Kraljevstvo.
',metaTitle:"Odredbe i uvjeti",metaDescription:"Ove Odredbe i uvjeti ističu pravila i regulacije u svezi korištenja IntechOpenove stranice www.intechopen.com i svih poddomena u vlasništvu IntechOpena, tvrtke sa sjedištem u 5 Princes Gate Court, London, SW7 2QJ, Ujedinjeno Kraljevstvo.",metaKeywords:null,canonicalURL:"/page/cro-terms-and-conditions",contentRaw:'[{"type":"htmlEditorComponent","content":"Pristupom na stranicu www.intechopen.com slažete se s ovim odredbama, sa svim primjenjivim zakonskim odredbama, te se slažete s poštovanjem svih lokalnih zakona. Korištenje i/ili pristup ovoj stranici temelji se na potpunom prihvaćanju ovih odredbi. Svi materijali na ovoj stranici zaštićeni su primjenjivim zakonima o autorskim pravima i žigu.
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\\n"}]'},components:[{type:"htmlEditorComponent",content:"Pristupom na stranicu www.intechopen.com slažete se s ovim odredbama, sa svim primjenjivim zakonskim odredbama, te se slažete s poštovanjem svih lokalnih zakona. Korištenje i/ili pristup ovoj stranici temelji se na potpunom prihvaćanju ovih odredbi. Svi materijali na ovoj stranici zaštićeni su primjenjivim zakonima o autorskim pravima i žigu.
\n\nSljedeća terminologija odnosi se na Odredbe i uvjete, te na sve naše ugovore:
\n\nKlijent, stranka, vi, vaš odnosi se na vas, osobu koja pristupa ovoj stranici i prihvaća IntechOpenove Odredbe i uvjete;
\n\nKompanija, tvrtka, mi, naše odnosi se na tvrtku IntechOpen;
\n\nStranke, strane odnosi se na klijenta i na nas, ili samo na klijenta ili nas.
\n\nSve odredbe koje se odnose na ponudu, prihvat ili razmatranje plaćanja, a za koja mi pružamo asistenciju klijentu, bilo na ugovoreni ili fiksni način, a s ciljem da se ostvare potrebe i želje klijenta u svezi s našim uslugama, su podložne zakonskim odredbama Ujedinjenog Kraljevstva.
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\n\nMaterijali koji se pojavljuju na IntechOpenovoj stranici mogu sadržavati manje greške, tipfelere ili fotografske greške. IntechOpen može napraviti promjene na bilo kojem materijalu koji se nalazi na stranici u bilo koje vrijeme.
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\n\nOve Odredbe i uvjeti su sastavljeni u skladu s odredbama prava Ujedinjenog Kraljevstva, a za sve sporove nadležan je sud u Londonu, Ujedinjeno Kraljevstvo.
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Research",isOpenForSubmission:!1,hash:"d7ef096c2bcf9efbda76d7631ce1e3ac",slug:"photodynamic-therapy-from-basic-science-to-clinical-research",bookSignature:"Natalia Mayumi Inada, Hilde Harb Buzzá, Kate Cristina Blanco and Lucas Danilo Dias",coverURL:"https://cdn.intechopen.com/books/images_new/7886.jpg",editedByType:"Edited by",editors:[{id:"90788",title:"Dr.",name:"Natalia Mayumi",middleName:null,surname:"Inada",slug:"natalia-mayumi-inada",fullName:"Natalia Mayumi Inada"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:155,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"32842",doi:"10.5772/34901",title:"Sterilization by Gamma Irradiation",slug:"sterilization-by-gamma-irradiation",totalDownloads:74772,totalCrossrefCites:37,totalDimensionsCites:85,abstract:null,book:{id:"1590",slug:"gamma-radiation",title:"Gamma Radiation",fullTitle:"Gamma Radiation"},signatures:"Kátia Aparecida da Silva Aquino",authors:[{id:"102109",title:"Dr.",name:"Katia",middleName:"Aparecida Da S.",surname:"Aquino",slug:"katia-aquino",fullName:"Katia Aquino"}]},{id:"49652",doi:"10.5772/61720",title:"Sample Preparations for Scanning Electron Microscopy – Life Sciences",slug:"sample-preparations-for-scanning-electron-microscopy-life-sciences",totalDownloads:8734,totalCrossrefCites:37,totalDimensionsCites:83,abstract:"Sample preparations are essential in scanning electron microscopy. Flawed sample preparations can undermine the quality of results and lead to false conclusions. Thus, the aim of this chapter is to equip researchers, post graduate students and technicians with essential knowledge required to prepare samples for scanning electron microscopy (SEM) investigations in the life sciences.",book:{id:"5075",slug:"modern-electron-microscopy-in-physical-and-life-sciences",title:"Modern Electron Microscopy in Physical and Life Sciences",fullTitle:"Modern Electron Microscopy in Physical and Life Sciences"},signatures:"Mogana Das Murtey and Patchamuthu Ramasamy",authors:[{id:"176330",title:"Dr.",name:"Mogana",middleName:"Das",surname:"Murtey",slug:"mogana-murtey",fullName:"Mogana Murtey"},{id:"181159",title:"Mr.",name:"Patchamuthu",middleName:null,surname:"Ramasamy",slug:"patchamuthu-ramasamy",fullName:"Patchamuthu Ramasamy"}]},{id:"30963",doi:"10.5772/34176",title:"Microstructural and Mineralogical Characterization of Clay Stabilized Using Calcium-Based Stabilizers",slug:"microstructural-and-mineralogical-characterization-of-clay-stabilized-using-calcium-based-stabilizer",totalDownloads:6790,totalCrossrefCites:29,totalDimensionsCites:48,abstract:null,book:{id:"1505",slug:"scanning-electron-microscopy",title:"Scanning Electron Microscopy",fullTitle:"Scanning Electron Microscopy"},signatures:"Pranshoo Solanki and Musharraf Zaman",authors:[{id:"20942",title:"Prof.",name:"Pranshoo",middleName:null,surname:"Solanki",slug:"pranshoo-solanki",fullName:"Pranshoo Solanki"},{id:"20945",title:"Prof.",name:"Musharraf",middleName:null,surname:"Zaman",slug:"musharraf-zaman",fullName:"Musharraf Zaman"}]},{id:"26791",doi:"10.5772/28067",title:"Optical Vortices in a Fiber: Mode Division Multiplexing and Multimode Self-Imaging",slug:"optical-vortices-in-a-fiber-mode-division-multiplexing-and-multimode-self-reproducing",totalDownloads:4531,totalCrossrefCites:29,totalDimensionsCites:48,abstract:null,book:{id:"2018",slug:"recent-progress-in-optical-fiber-research",title:"Recent Progress in Optical Fiber Research",fullTitle:"Recent Progress in Optical Fiber Research"},signatures:"S.N. Khonina, N.L. Kazanskiy and V.A. Soifer",authors:[{id:"72613",title:"Prof.",name:"Svetlana",middleName:null,surname:"Khonina",slug:"svetlana-khonina",fullName:"Svetlana Khonina"}]},{id:"49655",doi:"10.5772/61830",title:"Electrical Discharge in Water Treatment Technology for Micropollutant Decomposition",slug:"electrical-discharge-in-water-treatment-technology-for-micropollutant-decomposition",totalDownloads:4990,totalCrossrefCites:32,totalDimensionsCites:44,abstract:"Hazardous micropollutants are increasingly detected worldwide in wastewater treatment plant effluent. As this indicates, their removal is insufficient by means of conventional modern water treatment techniques. In the search for a cost-effective solution, advanced oxidation processes have recently gained more attention since they are the most effective available techniques to decompose biorecalcitrant organics. As a main drawback, however, their energy costs are high up to now, preventing their implementation on large scale. For the specific case of water treatment by means of electrical discharge, further optimization is a complex task due to the wide variety in reactor design and materials, discharge types, and operational parameters. In this chapter, an extended overview is given on plasma reactor types, based on their design and materials. Influence of design and materials on energy efficiency is investigated, as well as the influence of operational parameters. The collected data can be used for the optimization of existing reactor types and for development of novel reactors.",book:{id:"5093",slug:"plasma-science-and-technology-progress-in-physical-states-and-chemical-reactions",title:"Plasma Science and Technology",fullTitle:"Plasma Science and Technology - Progress in Physical States and Chemical Reactions"},signatures:"Patrick Vanraes, Anton Y. Nikiforov and Christophe Leys",authors:[{id:"49112",title:"Prof.",name:"Christophe",middleName:null,surname:"Leys",slug:"christophe-leys",fullName:"Christophe Leys"},{id:"176861",title:"Dr.",name:"Anton",middleName:null,surname:"Nikiforov",slug:"anton-nikiforov",fullName:"Anton Nikiforov"},{id:"176862",title:"Mr.",name:"Patrick",middleName:null,surname:"Vanraes",slug:"patrick-vanraes",fullName:"Patrick Vanraes"}]}],mostDownloadedChaptersLast30Days:[{id:"49562",title:"Laser-Induced Plasma and its Applications",slug:"laser-induced-plasma-and-its-applications",totalDownloads:4709,totalCrossrefCites:12,totalDimensionsCites:26,abstract:"The laser irradiation have shown a range of applications from fabricating, melting, and evaporating nanoparticles to changing their shape, structure, size, and size distribution. Laser induced plasma has used for different diagnostic and technological applications as detection, thin film deposition, and elemental identification. The possible interferences of atomic or molecular species are used to specify organic, inorganic or biological materials which allows critical applications in defense (landmines, explosive, forensic (trace of explosive or organic materials), public health (toxic substances pharmaceutical products), or environment (organic wastes). Laser induced plasma for organic material potentially provide fast sensor systems for explosive trace and pathogen biological agent detection and analysis. The laser ablation process starts with electronic energy absorption (~fs) and ends at particle recondensation (~ms). Then, the ablation process can be governed by thermal, non-thermal processes or a combination of both. There are several types of models, i.e., thermal, mechanical, photophysical, photochemical and defect models, which describe the ablation process by one dominant mechanism only. Plasma ignition process includes bond breaking and plasma shielding during the laser pulse. Bond breaking mechanisms influence the quantity and form of energy (kinetic, ionization and excitation) that atoms and ions can acquire. Plasma expansion depends on the initial mass and energy in the plume. The process is governed by initial plasma properties (electron density, temperature, velocity) after the laser pulse and the expansion medium. During first microsecond after the laser pulse, plume expansion is adiabatic afterwards line radiation becomes the dominant mechanism of energy loss.",book:{id:"5093",slug:"plasma-science-and-technology-progress-in-physical-states-and-chemical-reactions",title:"Plasma Science and Technology",fullTitle:"Plasma Science and Technology - Progress in Physical States and Chemical Reactions"},signatures:"Kashif Chaudhary, Syed Zuhaib Haider Rizvi and Jalil Ali",authors:[{id:"176684",title:"Dr.",name:"Kashif Tufail",middleName:null,surname:"Chaudhary",slug:"kashif-tufail-chaudhary",fullName:"Kashif Tufail Chaudhary"},{id:"176867",title:"Dr.",name:"Syed Zuhaib",middleName:null,surname:"Haider Rizivi",slug:"syed-zuhaib-haider-rizivi",fullName:"Syed Zuhaib Haider Rizivi"},{id:"176868",title:"Prof.",name:"Jalil",middleName:null,surname:"Ali",slug:"jalil-ali",fullName:"Jalil Ali"}]},{id:"52164",title:"An Overview on Quantum Cascade Lasers: Origins and Development",slug:"an-overview-on-quantum-cascade-lasers-origins-and-development",totalDownloads:3232,totalCrossrefCites:2,totalDimensionsCites:11,abstract:"This chapter presents an introductory review on quantum cascade lasers (QCLs). An overview is prefaced, including a brief description of their beginnings and operating basics. Materials used, as well as growth methods, are also described. The possibility of developing GaN-based QCLs is also shown. Summarizing, the applications of these structures cover a broad range, including spectroscopy, free-space communication, as well as applications to near-space radar and chemical/biological detection. Furthermore, a number of state-of-the-art applications are described in different fields, and finally a brief assessment of the possibilities of volume production and the overall state of the art in QCLs research are elaborated.",book:{id:"5389",slug:"quantum-cascade-lasers",title:"Quantum Cascade Lasers",fullTitle:"Quantum Cascade Lasers"},signatures:"Raúl Pecharromán-Gallego",authors:[{id:"188866",title:"Dr.",name:"Raúl",middleName:null,surname:"Pecharromán-Gallego",slug:"raul-pecharroman-gallego",fullName:"Raúl Pecharromán-Gallego"}]},{id:"49526",title:"Focused Ion Beams (FIB) — Novel Methodologies and Recent Applications for Multidisciplinary Sciences",slug:"focused-ion-beams-fib-novel-methodologies-and-recent-applications-for-multidisciplinary-sciences",totalDownloads:4299,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"Considered as the newest field of electron microscopy, focused ion beam (FIB) technologies are used in many fields of science for site-specific analysis, imaging, milling, deposition, micromachining, and manipulation. Dual-beam platforms, combining a high-resolution scanning electron microscope (HR-SEM) and an FIB column, additionally equipped with precursor-based gas injection systems (GIS), micromanipulators, and chemical analysis tools (such as energy-dispersive spectra (EDS) or wavelength-dispersive spectra (WDS)), serve as multifunctional tools for direct lithography in terms of nano-machining and nano-prototyping, while advanced specimen preparation for transmission electron microscopy (TEM) can practically be carried out with ultrahigh precision. Especially, when hard materials and material systems with hard substrates are concerned, FIB is the only technique for site-specific micro- and nanostructuring. Moreover, FIB sectioning and sampling techniques are frequently used for revealing the structural and morphological distribution of material systems with three-dimensional (3D) network at micro-/nanoscale.This book chapter includes many examples on conventional and novel processes of FIB technologies, ranging from analysis of semiconductors to electron tomography-based imaging of hard materials such as nanoporous ceramics and composites. In addition, recent studies concerning the active use of dual-beam platforms are mentioned",book:{id:"5075",slug:"modern-electron-microscopy-in-physical-and-life-sciences",title:"Modern Electron Microscopy in Physical and Life Sciences",fullTitle:"Modern Electron Microscopy in Physical and Life Sciences"},signatures:"Meltem Sezen",authors:[{id:"176338",title:"Associate Prof.",name:"Meltem",middleName:null,surname:"Sezen",slug:"meltem-sezen",fullName:"Meltem Sezen"}]},{id:"50866",title:"Effects of Different Laser Pulse Regimes (Nanosecond, Picosecond and Femtosecond) on the Ablation of Materials for Production of Nanoparticles in Liquid Solution",slug:"effects-of-different-laser-pulse-regimes-nanosecond-picosecond-and-femtosecond-on-the-ablation-of-ma",totalDownloads:6073,totalCrossrefCites:10,totalDimensionsCites:34,abstract:"Ultra-short laser pulse interaction with materials has received much attention from researchers in micro- and nanomachining, especially for the generation of nanoparticles in liquid environments, because of the straightforward method and direct application for organic solvents. In addition, the colloidal nanoparticles produced by laser ablation have very high purity—they are free from surfactants and reaction products or by-products. In this chapter, nanosecond, picosecond and femtosecond laser pulse durations are compared in laser material processing. Due to the unique properties of the short and ultra-short laser pulse durations in material processing, they are more apparent in the production of precision material processing and generation of nanoparticles in liquid environments.",book:{id:"5236",slug:"high-energy-and-short-pulse-lasers",title:"High Energy and Short Pulse Lasers",fullTitle:"High Energy and Short Pulse Lasers"},signatures:"Abubaker Hassan Hamad",authors:[{id:"183494",title:"Dr.",name:"Abubaker",middleName:"Hassan",surname:"Hamad",slug:"abubaker-hamad",fullName:"Abubaker Hamad"}]},{id:"49537",title:"Electron Diffraction",slug:"electron-diffraction",totalDownloads:10111,totalCrossrefCites:10,totalDimensionsCites:31,abstract:"Electron microscopes are usually supplied with equipment for obtaining diffraction patterns and micrographs from the same area of a specimen and the best results are attained if the complete use is to be made of these combined facilities. Electron diffraction patterns are used to obtain quantitative data including phase identification, orientation relationship and crystal defects in materials, etc. At first, a general introduction including a geometrical and quantitative approach to electron diffraction from a crystalline specimen, the reciprocal lattice and electron diffraction in the electron microscope are presented. The scattering process by an individual atom as well as a crystal, the Bragg law, Laue conditions and structure factor are also discussed. Types of diffraction patterns such as ring pattern, spot pattern and Kikuchi pattern, and general and unique indexing diffraction patterns are explained. The procedure for indexing simple, complicated and imperfect patterns as well as Kikuchi lines and a combination of Kikuchi lines and spots is outlined. The known and unknown materials are identified by indexing patterns. Practical comparisons between various methods of analysing diffraction patterns are also described. The basic diffraction patterns and the fine structure in the patterns including specimen tilting experiments, orientation relationship determination, phase identification, twinning, second phases, crystallographic information, dislocation, preferred orientation and texture, extra spots and streaks are described in detail. Finally, electron diffraction patterns of new materials are investigated.",book:{id:"5075",slug:"modern-electron-microscopy-in-physical-and-life-sciences",title:"Modern Electron Microscopy in Physical and Life Sciences",fullTitle:"Modern Electron Microscopy in Physical and Life Sciences"},signatures:"Mohsen Asadi Asadabad and Mohammad Jafari Eskandari",authors:[{id:"176352",title:"Dr.",name:"Mohsen",middleName:null,surname:"Asadi Asadabad",slug:"mohsen-asadi-asadabad",fullName:"Mohsen Asadi Asadabad"},{id:"177600",title:"Dr.",name:"Mohammad",middleName:null,surname:"Jafari Eskandari",slug:"mohammad-jafari-eskandari",fullName:"Mohammad Jafari Eskandari"}]}],onlineFirstChaptersFilter:{topicId:"20",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82228",title:"Nonlinear Intelligent Predictive Control for the Yaw System of Large-Scale Wind Turbines",slug:"nonlinear-intelligent-predictive-control-for-the-yaw-system-of-large-scale-wind-turbines",totalDownloads:9,totalDimensionsCites:0,doi:"10.5772/intechopen.105484",abstract:"This chapter presents a nonlinear intelligent predictive control using multi-step prediction model for the electrical motor-based yaw system of an industrial wind turbine. The proposed method introduces a finite control set under constraints for the demanded yaw rate, predicts the multi-step yaw error using the control set element and the prediction wind directions, and employs an exhaustive search method to search the control output candidate giving the minimal value of the objective function. As the objective function is designed for a joint power and actuator usage optimization, the weighting factor in the objective function is optimally determined by the fuzzy regulator that is optimized by an intelligent algorithm. Finally, the proposed method is demonstrated by simulation tests using real wind direction data.",book:{id:"11499",title:"Nonlinear Systems - Recent Developments and Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11499.jpg"},signatures:"Dongran Song, Ziqun Li, Jian Yang, Mi Dong, Xiaojiao Chen and Liansheng Huang"},{id:"82102",title:"Vortex Analysis and Fluid Transport in Time-Dependent Flows",slug:"vortex-analysis-and-fluid-transport-in-time-dependent-flows",totalDownloads:10,totalDimensionsCites:0,doi:"10.5772/intechopen.105196",abstract:"In this contribution, we present a set of procedures developed to identify fluid flow structures and characterize their space-time evolution in time-dependent flows. In particular, we consider two different contests of importance in applied fluid mechanics: 1) large-scale almost 2D atmospheric and oceanic flows and 2) flow inside the left ventricle in the human blood circulation. For both cases, we designed an ad hoc experimental model to reproduce and deeply investigate the considered phenomena. We will focus on the post-processing of high-resolution velocity data sets obtained via laboratory experiments by measuring the flow field using a technique based on image analysis. We show how the proposed methodologies represent a valid tool suitable for extracting the main patterns and quantify fluid transport in complex flows from both Eulerian and Lagrangian perspectives.",book:{id:"10958",title:"Vortex Dynamics - From Physical to Mathematical Aspects",coverURL:"https://cdn.intechopen.com/books/images_new/10958.jpg"},signatures:"Stefania Espa, Maria Grazia Badas and Simon Cabanes"},{id:"82222",title:"High-Lying Confined Subbands in Terahertz Quantum Cascade Lasers",slug:"high-lying-confined-subbands-in-terahertz-quantum-cascade-lasers",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.105479",abstract:"In designing the terahertz quantum cascade lasers, electron injection manner indeed plays a significant role to achieve the population inversion. The resonant tunneling process is commonly employed for this injection process but waste more than 50% fraction of populations out of the active region owing to resonance alignment, and the injection efficiency is obviously degraded due to thermal incoherence. An alternative approach is to consider the phonon-assisted injection process that basically contributes to most of the populations to the upper lasing level. However, this manner is still not realized in experiments if a short-period design only containing two quantum wells is used. In this work, it is found in this design that the population inversion is indeed well improved; however, the optical gain is inherently low even at a low temperature. Those two opposite trends are ascribed to a strong parasitic absorption overlapping the gain. The magnitude of this overlap is closely related to the lasing frequency, where frequencies below 3 THz suffer from fewer effects.",book:{id:"11495",title:"Fundamentals and Application of Femtosecond Optics",coverURL:"https://cdn.intechopen.com/books/images_new/11495.jpg"},signatures:"Li Wang"},{id:"82149",title:"Colorimetric Evaluations and Characterization of Natural and Synthetic Dyes/Pigments and Dyed Textiles and Related Products",slug:"colorimetric-evaluations-and-characterization-of-natural-and-synthetic-dyes-pigments-and-dyed-textil",totalDownloads:7,totalDimensionsCites:0,doi:"10.5772/intechopen.104774",abstract:"This book chapter covers principles and few case studies on colorimetric Estimation of (i) determining purity/active ingredient % of selective dyes/pigments (ii) Identification of any colorants to distinguish from other similar compound, (iii) Measurement of surface colour strength of a dyed textile, (iv) Measurement of colour differences by estimating DE, DL*, Da*, Db*, DC and DH values, (v)Computer-aided colour match prediction for any standard shades, (vi) Estimation of compatibility of two dyes/colourants to use for compound shades, (vii) Determination of rate of dyeing, dyeing isotherm and dyeing kinetics to control dyeing, (viii) Optimization of dyeing process variables, (ix) Precession grading of Colour Fastness of dyed textiles on fading under different ways/agencies and (x) Estimation of Soil Removal efficacy of different detergent used for textiles. These colorimetric measurements are found to be very useful for effective process and product control of dyed textile materials. Selected Case studies on all the above colorimetric applications with specific example or experimented data are discussed for each of the method under reference. Finally, the other applications of colorimetric analysis besides textiles industry are also mentioned in concluding remarks.",book:{id:"11002",title:"Colorimetry",coverURL:"https://cdn.intechopen.com/books/images_new/11002.jpg"},signatures:"Ashis Kumar Samanta"},{id:"82116",title:"Thermo-Rheological Effect on Weak Nonlinear Rayleigh-Benard Convection under Rotation Speed Modulation",slug:"thermo-rheological-effect-on-weak-nonlinear-rayleigh-benard-convection-under-rotation-speed-modulati",totalDownloads:11,totalDimensionsCites:0,doi:"10.5772/intechopen.105097",abstract:"The effects of rotation speed modulation and temperature-dependent viscosity on Rayleigh-Benard convection were investigated using a non-autonomous Ginzburg-Landau equation. The rotating temperature-dependent viscous fluid layer has been considered. The momentum equation with the Coriolis term has been used to describe finite-amplitude convective flow. The system is considered to be rotating about its vertical axis with a non-uniform rotation speed. In particular, we assume that the rotation speed is varying sinusoidally with time. Nusselt number is obtained in terms of the system parameters and graphically evaluated their effects. The effect of the modulated system diminishes the heat transfer more than the un-modulated system. Further, thermo-rheological parameter VT is found to destabilize the system.",book:{id:"11498",title:"Boundary Layer Flows - Modelling, Computation, and Applications of Laminar, Turbulent Incompressible and Compressible Flows",coverURL:"https://cdn.intechopen.com/books/images_new/11498.jpg"},signatures:"S.H. Manjula and Palle Kiran"},{id:"81712",title:"Atomic Force Microscope in Forensic Examination",slug:"atomic-force-microscope-in-forensic-examination",totalDownloads:7,totalDimensionsCites:0,doi:"10.5772/intechopen.104704",abstract:"Criminal activities have their footprints from time immemorial and nature of crime has drastically changed over a period of time. There is neither a geographical boundary, nor technical limitations. Moreover terrorist’s activities, drug trafficking eco-crimes, high-profile crimes, robbery hit and run cases, building collapse, petroleum products adulteration are some of latest forms of crimes. In last 20 years, scanning probe microscopes have emerged as an essential technique in various fields, and atomic force microscope (AFM) is most commonly used scanning probe technique which has shown its wide range of application in examination of various evidences encountered on crime scene. Major advantages of AFM involve its high resolution in three dimensions, and sample is not necessary to be conductive and it does not need to be operated within a vacuum. It helps in studying a large range of topographies and many types of materials can be imaged under it. Evidences such as blood, fibers, hair, soil, finger prints, gunshot residue, pollen, etc. found on crime scene at nano- or micro-level can be examined under AFM. The chapter describes applications of AFM with respect to its application in examination of evidences that can help in bringing justice.",book:{id:"11146",title:"Electron Microscopy",coverURL:"https://cdn.intechopen.com/books/images_new/11146.jpg"},signatures:"Niha Ansari"}],onlineFirstChaptersTotal:38},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. 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He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. 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She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:36,paginationItems:[{id:"82195",title:"Endoplasmic Reticulum: A Hub in Lipid Homeostasis",doi:"10.5772/intechopen.105450",signatures:"Raúl Ventura and María Isabel Hernández-Alvarez",slug:"endoplasmic-reticulum-a-hub-in-lipid-homeostasis",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"82409",title:"Purinergic Signaling in Covid-19 Disease",doi:"10.5772/intechopen.105008",signatures:"Hailian Shen",slug:"purinergic-signaling-in-covid-19-disease",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82374",title:"The Potential of the Purinergic System as a Therapeutic Target of Natural Compounds in Cutaneous Melanoma",doi:"10.5772/intechopen.105457",signatures:"Gilnei Bruno da Silva, Daiane Manica, Marcelo Moreno and Margarete Dulce Bagatini",slug:"the-potential-of-the-purinergic-system-as-a-therapeutic-target-of-natural-compounds-in-cutaneous-mel",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82103",title:"The Role of Endoplasmic Reticulum Stress and Its Regulation in the Progression of Neurological and Infectious Diseases",doi:"10.5772/intechopen.105543",signatures:"Mary Dover, Michael Kishek, Miranda Eddins, Naneeta Desar, Ketema Paul and Milan Fiala",slug:"the-role-of-endoplasmic-reticulum-stress-and-its-regulation-in-the-progression-of-neurological-and-i",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}}]},overviewPagePublishedBooks:{paginationCount:32,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science\nand Technology from the Department of Chemistry, National\nUniversity of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013.\nShe relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the\nNational Institute of Fundamental Studies from April 2013 to\nOctober 2016. She was a senior lecturer on a temporary basis at the Department of\nFood Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is\ncurrently Deputy Principal of the Australian College of Business and Technology –\nKandy Campus, Sri Lanka. She is also the Global Harmonization Initiative (GHI)",institutionString:"Australian College of Business & Technology",institution:null}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"7978",title:"Vitamin A",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7978.jpg",slug:"vitamin-a",publishedDate:"May 15th 2019",editedByType:"Edited by",bookSignature:"Leila Queiroz Zepka, Veridiana Vera de Rosso and Eduardo Jacob-Lopes",hash:"dad04a658ab9e3d851d23705980a688b",volumeInSeries:3,fullTitle:"Vitamin A",editors:[{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka",profilePictureURL:"https://mts.intechopen.com/storage/users/261969/images/system/261969.png",biography:"Prof. Dr. Leila Queiroz Zepka is currently an associate professor in the Department of Food Technology and Science, Federal University of Santa Maria, Brazil. She has more than fifteen years of teaching and research experience. She has published more than 550 scientific publications/communications, including 15 books, 50 book chapters, 100 original research papers, 380 research communications in national and international conferences, and 12 patents. She is a member of the editorial board of five journals and acts as a reviewer for several national and international journals. 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He is especially interested in the genetic differentiation pattern and speciation process that correlate to the flashing pattern and mating behavior of some fireflies in Japan. He then worked for Olympus Corporation, a Japanese manufacturer of optics and imaging products, where he was involved in the development of luminescence technology and produced a bioluminescence microscope that is currently being used for gene expression analysis in chronobiology, neurobiology, and developmental biology. 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{na