Comparison of Hounsfield units and relative electron densities of organs.
\r\n\tThis publication will aim to collect those projects and research that seek to make buildings, including urban environments, self-sufficient in terms of energy, focusing here on the solutions for HVAC and the energy systems they require and doing so from a double point of view:
\r\n\t- Complexity. As is the case with the automobile and aeronautics industries, buildings have become human-inhabited spaces with an ever-increasing technological load, which will presumably also be used in other ways, as the pandemic associated with COVID-19 has shown. In these scenarios, will HVAC systems be considered as before, or will new solutions have to be considered for new challenges?
\r\n\t- Disruptive technologies. In the coming years, the implementation of technologies such as hydrogen fuel cells, polygeneration of energy, the use of second-use electric batteries in buildings to accumulate energy from renewable energies, or the resolution of constructive solutions with 3D printing will become widespread in buildings. In this scenario, what will be the answers given by those responsible for HVAC systems?
\r\n\tIn addition, concepts such as artificial intelligence, technology transfer, biomimicry, or stigmergy will undoubtedly provide high-value solutions to new and refurbished buildings that society demands.
According to the National Institute for Occupational Safety and Health [1], musculoskeletal disorder (MSD) is a damage that affects the musculoskeletal system of the human body, especially at bones, spinal discs, tendons, joints, ligaments, cartilage, nerves, and blood vessels. Such injuries may result due to repetitive motions, forces, and vibrations on human bodies during executing certain job activities. Previous injuries, physical condition, heredity, pregnancy, lifestyle, and poor diet are the factors that contribute to the musculoskeletal symptoms.
\nWork-related musculoskeletal symptoms can be observed at workplaces when there is a discrepancy between the physical capacity of the human body and the physical requirements of the task. Musculoskeletal disorders can be related to the work activities and conditions, and they could significantly contribute to the development of MSDs. However, these are not necessarily the only causes or significant risk factors.
\nThe World Health Organization recognizes conditions that result in pain and functional impairment that affect the neck, shoulders, elbows, forearms, wrists, and hands as work related when the work activities and work conditions significantly contribute to the development of work-related disorders (Figure 1).
\nFactors scheme.
Work-related musculoskeletal disorders (WRMSDs) are described as wide range of degenerative and inflammatory conditions that affect the supporting blood vessels, peripheral nerves, joints, ligaments, tendons, and muscles. Such conditions could result in functional impairment and pain which are widely experienced at the upper extremities and the neck [2].
\nAt the workplace, the causes of musculoskeletal disorders are diverse but poorly understood. Aptel et al. [3] stated that biomechanical factors such as repetitive motion, strenuous efforts, extreme joint postures, and/or psychosocial factors establish the key role in work-related musculoskeletal disorders. In [4], it is provided that certain psychological factors are associated with musculoskeletal discomfort and may eventually provide one way to intervene to reduce MSDs.
\nThis chapter aims to analyze the ergonomics, administration of occupational health and safety, economic impact, prevalence, intervention, and prevention of WRMSDs.
\nHales and Bernard [5] cited the causes of work-related musculoskeletal symptoms in two categories: physical and psychosocial.
\nThese include intense, repeated, or sustained exertions; awkward, non-neutral, and extreme postures; rapid work pace; repeated and/or prolonged activity; insufficient time for recovery, vibration, and cold temperatures.
\nThe muscles and joints involved in an activity and the amount of stress or force tolerated or generated are determined by the body posture due to the fact that as the back bends, there is more stress exerted on the spinal discs during object lifting, handling, or lowering than when the back is straight. The tasks requiring sustained or repeated twisting or bending of the shoulders, wrists, hips, and the knees also increase the stress on the joints. Therefore, prolonged or frequent work activities can be very stressful.
\nFrequently repeated motions (e.g., every few seconds) and prolonged periods could end up in accumulated muscle-tendon strain and fatigue. If the time allocated between the exertions is sufficient, the muscles and tendons can recover from forceful exertions and stretching effects. During inappropriate postures and forceful exertions, the impact of repetitive motions due to performing the same work activities can be increased. Risk factor such as repetitive actions can also depend of the performed specific act and the body area.
\nThe amount of time that someone is continuously exposed to a risk factor is called duration. The job tasks that require the use of the same motions or muscles for long periods increase the probability of general and local fatigue. Generally, if the period of the continuous work increases (for the tasks require extended muscle contraction), more rest or recovery period is required.
\nWithin a given period of time, the number of repeated exertions by a person is defined as frequency. In fact, if the exertion is repeated more often, the speed of movement of the exerted body part increases. Moreover, the recovery period decreases when more frequent exertion is completed, and this increases the probability of general and local fatigue with the duration.
\nWRMSDs do not only result in the physical stressors. However, a set of multiple factors determine the formation. Psychosocial risk factors such as stressful job, social pressure at work, and job dissatisfaction are such factors which contribute to the formation of WRMSDs. When an injury occurs, psychosocial factors, such as incongruous pain and depression, are the main reasons for the development of a disability and transition from acute to chronic pain [6].
\nThese include monotonous work, time pressure, a high workload, unorganized work-rest schedules, complexity of tasks, career concerns, lack of peer support, a poor relationship between workers and their supervisors, and poor organizational characteristics (climate, culture, and communications).
\nThe way to structure and manage the work processes are called as organization of work and it deals with the following subjects:
Work scheduling (work-rest schedules, work hours, and shift work).
Job design (task complexity, required effort and skill, and the degree of control of work).
Interpersonal facets of work (relationships with colleagues, subordinates, and supervisors).
Concerns regarding career (job security and opportunities to grow).
Style of management (teamwork and participatory management).
Characteristics of the organization (culture, communication, and climate).
Many of the above components are called as “psychosocial factors,” and they are known as risk factors for psychological strain and job stress. Stress is a conceived emotional and physical reaction of the human body to events or circumstances which cause excitement, danger, confusion, irritation, or frightening. Particularly, it is a transition from someone’s normal behavior according to a cause that results in tear and wear on the body’s mental or physical resources.
\nThere are internal or external stimuli that cause stress. The internal stimuli are those stressors that involve self-expectations, impersonal barriers, and conflicting desires. Apparently, internal stimuli depend on personal aspects. However, external stimuli include situations where expectations, time limit, lack of resources, and lack of vision and goals present.
\nStressors may be physiological, psychological, social, environmental, developmental, spiritual, or cultural and represent unmet needs. Stress causes changes in the human body that are usually centered on the nervous system and endocrine system. Therefore, the human body’s internal environment is constantly changing, and the body’s adaptive mechanisms continually function to adjustments in heart rate, respiratory rate, blood pressure, temperature, fluid and electrolyte balances, hormone secretions, and level of consciousness.
\nIntensive and extensive stress results in disorders in the musculoskeletal system. Emotions like anger, frustration, irritation, confusion, tension, and nervousness cause the stress. It is not only the experience and frequency of such feelings but also the repetition of the activities and motions that induce injuries or musculoskeletal disorders.
\nIn considering human emotions and feelings and applying the results of the research to their impact on the musculoskeletal system, it is probably platitudinous to make a statement that the greater the knowledge and understanding of the human being, the better the result obtained. In order to identify and understand the effect of the emotions on the musculoskeletal system, important risk factors for musculoskeletal disorders should be recognized.
\nMoreover, together with the above conditions, some other work aspects contribute to both physical and psychological stress as well. The human body in fact is limited in kinematic motions as it is a mechanism formed by biological characteristics. Beyond this, it also includes a brain which thinks, reasons, and feels. Thus, feelings such as joy, pain, anger, sadness, depression, frustration, outrage, boredom, fear, jealousy, hate, love, and (even) schizophrenia are experienced by human beings.
\nWhen exposed to stress, human beings show responses such as fear, frustration, anger, fatigue, tension, depression, anxiety, helplessness, confusion, and lack of vigor.
\n\n
Tendonitis: it is the most common hand problem, which happens when the tendons connecting the fingers to muscles in the forearms get inflamed. Tendons help attach muscle to bone to allow movement of a joint [7].
Tenosynovitis: this is another common ailment, where the synovial sheaths (sacks filled with fluid) swell which surround and protect the tendons. Carpal tunnel syndrome (CTS) is the condition which is a result of this swelling. The carpal tunnel is a small opening close to the bottom of the hand which accommodates the tendons and the median nerve that provides sensation to the hand. In the case of swelling of the synovial sheaths, the carpal tunnel cramps and puts pressure on the nerve. There are several syndromes of the CTS, but the most frequent ones are numbness, tingling, or a burning sensation in the palms, fingers, and wrists. These conditions can lead to strength and sensation loss in the hands in time [7].
Nerve compression: throughout the body, there are several nerves that transmit signals from the body parts to the brain. These often move in the spine through small tunnels available between the vertebrae. There are many conditions which cause the nerves to become compressed, pinched, or squeezed, which can result in weakness, numbness, severe pain, and loss of coordination. The condition in which the sciatic nerve in the spine becomes compressed is known as sciatica. The symptoms of this condition appear in the back of the leg and at the side of the foot [7].
Raynaud’s syndrome/disease: this is a loss of blood circulation, which results in whitening and numbness of the finders. It is sometimes called “white finger,” “wax finger,” or “dead finger” [7].
Reflex sympathetic dystrophy: this is a rare, incurable condition characterized by fry, swollen hands and loss of muscle control. It is consistently painful [7].
Ganglion cyst: this disorder arise when a swelling or lump in the wrist resulting from jelly-like substance leaks from a joint or tendon sheath [7].
Cervical radiculopathy: this is the condition of an injury due to the extending out of those nerves that provide sensation and trigger movement from cervical vertebrae which result in weakness, numbness, or pain in the hand, wrist, arm, or shoulder [7].
Lateral epicondylitis: this is a condition when the outer part of the elbow becomes painful and tender, usually as a result of a specific strain, overuse, or a direct bang [7].
Rheumatoid arthritis: this is a disabling autoimmune disease which is progressive and happens in a long term. It causes pain, swelling, and inflammation in and around the joints and other body organs. Hands and feet are affected mainly, but it can be seen in any joint as well. It usually occurs at the same joints on both sides of the body [7].
Musculoskeletal disorders (MSD) are a major concern globally not just due to the pain and disability suffered by the individual worker but also due to its economic impact not just on the employer but also on the society as a whole. In 2013/2014, 8.3 million work days were lost in UK due to musculoskeletal disorders [8]. In the European Union (EU), more than 40 million workers are affected by musculoskeletal disorders that translate to one in seven people [9]. In the USA, musculoskeletal disorders accounted for 29–35% of the occupational injuries in private industries which resulted in absence from work from 1992 to 2010 [10].
\nFinancial costs due to musculoskeletal disorders can be divided into direct costs and indirect costs. Direct costs are the costs mainly comprised of medical expenditures which are used to cure and/or prevent diseases. These include resources such as hospitals, doctors, equipment, etc. Indirect costs are the hidden costs which include costs due to loss of productivity, training, and hiring costs of new employees. These productivity losses occur when either the person is sick and does not show up at work or his productivity is reduced while at work due to sickness. There is also cost due to loss of unpaid work due to sickness when the person is not able to do his household tasks.
\nIn both manufacturing and service sector, productivity loss is one of the biggest and severe problems. Organizations suffer from decreased job productivity and employee absence which then creates significant economic burden not just for them but for the economy as a whole. Despite significant indirect costs due to musculoskeletal disorders, many economic evaluations done by countries exclude these costs which are greater than the direct costs. Even the countries which do include these costs significantly vary in their methodology from one another due to disagreement over the current methods and the certain flaws in them.
\nIgnoring or including only some part of these costs in economic evaluations has a twofold effect: firstly, health benefits as a result of a proposed health intervention are underestimated and, secondly, not enough resources are allocated to research in workplace safety and health as a result of under estimation of these costs. In the USA, despite occupational injuries costing society up to $250 billion, a budget of $0.3 billion was allocated to the National Institute of Occupational Safety and Health (NIOSH) in 2013 [11]. This compared with budget of $5 billion for National Cancer Institute which costs society up to $219 billion.
\nFor businesses to remain competitive, it is important that research of safe workplace practices is promoted and the businesses are given guidance about workplace safety because without a healthy human resource, no entity can grow. This can only happen when these costs are captured in economic evaluations and given their due attention by both the employer and the society as a whole.
\nCalculation of costs of MSDs is not straightforward as several factors need to be considered before total costs are computed. The following components need to be estimated to calculate the total costs of MSDs [12].
Direct costs: these are the costs spent on management of musculoskeletal disorders, i.e., medical costs, administrative, compensation, and insurance costs. These costs are visible, and estimation of these is straightforward. These costs are not within the scope of this chapter and thus would not be discussed further.
Indirect costs: these are hidden costs which include costs for lost productivity both paid and unpaid, lost earnings and tax revenues, lost opportunity costs for careers, and costs of hiring and training new workers. These costs are difficult to estimate, and in the literature, most of the debate is around calculation of these costs. This will be discussed later in detail.
Intangible costs: this includes psychosocial burden such as job stress, family stress, and economic stress which leads to reduced quality of life [12]. As these costs are very difficult to express in monetary terms, they are rarely considered for cost calculations. But intangible costs give useful information about the quality of life of people with MSDs and help in measuring effectiveness of the interventions. Intangible costs are usually expressed with the help of a measure called quality adjusted life years (QALY). Even though these costs are not the focus of this study, they have been mentioned in the context of explaining methods of measuring indirect costs.
Coyte et al. [13] estimated that the total cost of musculoskeletal costs in Canada in 1994 was $25.6 billion (Canadian) which equates to 3.4% GDP of Canada. Indirect costs were 2.4 times of the direct costs. Lost productivity cost due to disability was $13.9 billion dollars which is 54.3% of the total cost.
\nThe French Government in a press release part of national Plan on Health & Safety at Work (Plain Sante Travail 2005–2009) highlighted that 75% of all the occupational diseases in 2005 were musculoskeletal disorders [14]. Thirty-one thousand diseases were compensated which lead to loss of 6.5 million work days and 650 million EUR. Indirect costs are not included in this amount.
\nIn the UK, 8.3 million days were lost due to MSDs in 2013/2014, which equates to 15.9 days per case of MSDs [8]. It cost around £4.5 billion in lost productivity to Britain due to work-related illnesses in 2012/2013 [15]. The direct cost of MSD in Korea is estimated as $4.5 billion, whereas cost due to loss of productivity is $2.28 billion [16]. The total economic cost was estimated to be $6.89 billion, which amounts to 0.7% of the GDP.
\nIn the USA, the economic cost of MSDs is estimated between $45 and 54 billion [17]. These include costs such as compensation costs, lost productivity, and lost wages. In the USA, work-related musculoskeletal disorders (WRMSD) account for 34% lost workdays; direct costs for worker compensations are estimated to be $20 billion, whereas indirect costs can be five times more than the direct costs [18].
\nData which is available in a German national report on safety and health estimated that 95 million days are lost due to MSD which costs €23.9 [14]. Wenig et al. [19] calculated the total costs for back pain for Germany. The study indicated a cost of around 49 billion EUR. Average back pain costs were around 1300 EUR per patient per year. 46% of the total comprised of direct costs and 54% comprised of indirect costs.
\nDeloitte Access Economics calculated the indirect costs for people with arthritis and other musculoskeletal conditions to be $11.2 billion in Australia in 2012 [20]. This amount is 55% of the total health cost. Out of this amount, productivity costs accounted for $7.4 billion, which included costs associated with reduced employment ($6 billion), lost superannuation, absenteeism, and presenteeism.
\nIn a French study commissioned by the national working conditions agency (ANACT) to estimate cost of MSDs in three companies with more than 500 employees, it was found that indirect costs were 10–30 times higher than direct costs [14]. Total cost was between €6800 and €11,200 per employee.
\nThe European Agency for Safety and Health at Work (2008) suggested that it is possible to draw the following conclusions about the different types of interventions based on the randomized and non-randomized comparative studies in the workplace, trials without a comparison group, and laboratory studies:
Organizational and administrative interventions. Only a few studies were conducted on these type of interventions. In physically demanding works, the evidence is limited to show that the disorders at the neck and shoulder regions can be reduced when there is a reduction in daily work hours (from 7 to 6 hours). Also, it has been shown that without productivity loss, it is possible to introduce extra breaks within repetitive work. However, the methods to be applied prevent the occurrence of MSDs effectively are not clear and yet requires to be studied.
Technical, engineering, or ergonomic interventions. The workload on the back without any productivity loss can be reduced by applying certain technical measures. Very few evidence is available to illustrate that these measures can reduce absenteeism due to illness and low back disorders. However, there is strong evidence to show that the load on the shoulders, arms, and hands can be reduced by ergonomic hand tools. Moreover, literature is limited to illustrate the reduction of MSDs due to manual computer tasks or vibration.
Protective equipment. It is not clear whether the use of back belts helps or hurts the back pain. It could not be achieved scientifically that the use of back belt can prevent back pain during manual material handling. Also, there is no evidence on prevention of upper limb disorders by using other protective equipment.
Behavioral modification. It is widely discussed in the literature that training on work methods is not adequate if it is used as the sole measure to prevent the back pain. Reduction in the relapses of shoulder-neck pain and back pain by physical training is another issue which yet requires to be studied extensively. Therefore, the training should involve dynamic exercises, which are to be repeated three times a week at least, in order to be effective.
Occupational injuries pose costly health problems (direct cost) and lost productivity (indirect cost) problems in workplaces where people are engaged in intensive, repetitive action and long hours of work. Direct costs occupy only 25% of the total induced cost of WRMSDs. Thus, ergonomic interventions in the workplace should be organized to focus on the reduction of the lost productivity, as it occupies the majority of the costs.
\nAlone or in a combination, the risk factors that contribute to the formation of WRMSDs can be physical, psychological, or psychosocial. Psychosocial and physical occupational risk factors should be analyzed in detail to understand the effect on the organization. Primarily, the working conditions should be analyzed for awkward postures and repetitive jobs.
\nWRMSDs may cause pain, slow responses, increased probabilities of accidents, reduced quality of life, and working ability. Therefore, both the individuals and the organizations should accept the fact that they are under a constant risk, and they should get ergonomic training in which they should apply at every step of their lives to be protected from WRMSDs.
\nRadiation therapy would not exist without physics. It begins with the discovery of X-rays. This therapy uses ionizing radiation, which is delivered by a linear accelerator. Linear accelerator is a device that uses high-frequency electromagnetic waves to accelerate charged particles, such as electrons to high energies through a linear tube. The high-energy electron beam itself can be used for treating a superficial target, or it can be made to strike a target to produce x-rays for treating a deep-seated target. Radiation therapy works by damaging the DNA of cancerous cells. Photons cause indirect ionization, which happens as a result of the ionization of water, forming free radicals, which then damage. Charged particles, such as electrons, protons, boron, carbon, and neon ions can cause direct damage to target through high-LET (linear energy transfer) [1]. The main focus of physics in radiation therapy is to increase the level of precision and accuracy of dose delivery to the target volume. From the 1950s to the late 1980s, the approach to radiation therapy was based on a two-dimensional (2D) approach. In 2D radiation therapy, plans were created manually, and a single beam used to be given from one to four directions [2]. Shielding blocks were used to collimate the beam. Advances in imaging technology like Ultrasound (US), Computed Tomography (CT), Magnetic Resonance Imaging (MRI), etc. significantly changed the practice of radiation therapy from the 2D method to a Three Dimensional Conformal Therapy (3DCT), which conforms to the high radiation dose with uniform intensity to tumor. For precise shaping of treatment field to the target volume, Multi-Leaf Collimator (MLC) system was developed in place of shielding blocks [3]. Advanced form of radiation therapy called Intensity Modulated Radiation Therapy (IMRT) has been developed in the mid-1990s and early 2000s. IMRT can provide conformal dose distribution compared with 3DCRT [3]. Intensity-Modulated Arc Therapy (IMAT) uses the Multi-Leaf Collimator (MLC) dynamically to shape the fields, as well as rotate the gantry in the arc therapy mode. Intensity-Modulated Arc Therapy (IMAT) was further improved with the addition of variable gantry rotation speeds and dose rates and was introduced as volumetric-modulated arc therapy (VMAT) in 2007. Brief descriptions of all these techniques are discussed in the following sections.
Three-Dimensional Conformal Radiation Therapy (3DCRT) means conformal dose distribution in terms of adequate dose to the tumor and minimum possible dose to normal tissue based on 3D anatomic information. The main distinction between treatment planning of 3DCRT and that of conventional radiation therapy is that treatment planning system optimizes dose distribution in accordance with the clinical objectives using anatomic information. Depending on imaging modality, visible tumor, the suspected tumor spread, patient motion uncertainties, critical structures, and relevant landmarks are outlined slice by slice by the radiation oncologist. This technique, however, fails in achieving conformal dose distribution for patient geometries where Organ at Risks (OARs) are located in close proximity to or are even embedded within complicated tumor shapes. Due to lesser conformity of dose distribution in Three-Dimensional Conformal Radiation Therapy (3DCRT), it may be insufficient to allow adequate escalation of tumor dose and there is a need for further improvement. It is possible only with intensity-modulated radiotherapy.
Intensity-modulated radiotherapy (IMRT) is an advanced form of 3-D conformal radiation therapy that allows modifying the intensity of the beam by considering each radiation beam as multiple rays or beamlets, and assigning different beam strengths to the individual rays [4]. The radiation intensity is adjusted according to the shape, size, and location of the tumor with the use of computer-controlled, moveable “leaves” called Multi-Leaf Collimator (MLC) systems. It consists of pairs of highly absorbing tungsten leaves that can either block or allow the passage of radiation from the many beams as shown in Figure 1 to deliver a high dose to the target volume and acceptably low dose to the surrounding normal structures [5].
Multileaf collimators (MLCs).
It uses advanced imaging procedures such as Ultrasound (US), Computed Tomography (CT), Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), and PET/CT, to achieve precise treatment modality for cancer patients [6]. A computer-controlled multileaf collimator has been programmed in three different ways to deliver IMRT [7].
Multi-segmented Static field Delivery: The patient is treated by multiple fields and each field is subdivided into a set of subfields [8]. The subfields are created by the MLC. The radiation beam is turned off when the leaves are moving from one field segment to another and is turned on only when the leaves reach and stop at the designated segment positions [9]. This method of IMRT delivery is also called “step-and-shoot” or “stop-and-shoot” [10].
Dynamic Delivery: In this technique, the beam is kept on while the corresponding leaves sweep simultaneously to produce the desired intensity modulation throughout the treatment delivery [11].
Intensity-modulated Arc therapy: Yu has developed an Intensity Modulated Arc Therapy (IMAT) technique. IMAT technique is similar to IMRT, which uses the dynamic mode of dose delivery to shape the fields with gantry rotation and the beam is on all the time [12].
Intensity-Modulated Arc Therapy (IMAT) has been improved with the addition of variable gantry rotation speeds and dose rates and was introduced as Volumetric-Modulated Arc Therapy (VMAT) in 2007 to describe rotational Intensity Modulated Radiotherapy (IMRT) delivered in a “single arc” [13]. VMAT can provide highly conformal dose distributions and can significantly improve the Intensity Modulated Radiotherapy (IMRT) delivery efficiency. The faster treatments reduce the effects of intra-fractional motion on both tumors and organs, and of course, the shorter treatment times also increase patient comfort. The high plan quality and fast treatment delivery of Volumetric-Modulated Arc Therapy (VMAT) are attractive, and it has been widely applied to many disease sites.
In external beam radiation therapy, the energy deposition is three-dimensional in nature. As such particles not only interact with the tumor site but also deposit some of their energy into the adjacent area. Consequently, neighboring normal tissues also receive some amount of radiation dose in this process. Therefore, normal tissue dose tolerance becomes a limiting factor to the success of the treatment. Therefore, a scheduled quality assurance program should be established to verify the plans generated on Treatment Planning System (TPS).
The dose distribution given by Intensity Modulated Radiation Therapy (IMRT) is highly conformal, compared to conventional radiotherapies. But due to the presence of large numbers of fields and irregular shape and size of the treatment segments, the accuracy of Intensity Modulated Radiation Therapy (IMRT) delivery needs to be verified via measurement of dose. Based on the recommendations of the International Atomic Energy Agency (IAEA) published in technical reports series number 277 and 398, there are several techniques to attain accuracy in dosimetry.
Different dosimetry techniques are available to compare the planned dose with delivered dose using an ionization chamber and commercially available phantom, such as slab phantom that measures the point dose at a particular desired reference depth. For reference dosimetry, radiographic film or radiochromic film is placed at a particular depth in slab phantom, and a planned dose is delivered on it. The film quality assurance dosimetry system, for instance, OmniPro IMRT correlates the resultant density of film with the planned dose at each point.
Luminescence dosimetry is also performed using an optically stimulated luminescence (OSL) system and thermoluminescent dosimeters (TLD). It can be also used for in vivo dosimetry in which OSL or TLD are placed on patient’s body at reference points for measurement. The electronic portal imaging device is also utilized for reference dosimetry. In addition, many detector-based phantoms are available, for reference dosimetery, such as Accua Check, Delta 4 phantom.
To evaluate an institution’s ability to deliver the planned dose to patients, an indigenous heterogeneous phantom has been designed.
The majority of the commercially available phantoms are of homogeneous density, whereas the actual human body is a complex medium of different density patterns [14]. Additionally, the very few heterogeneous phantoms, which are available commercially (e.g. anthropomorphic phantom) are very costly and are not procured by most radiotherapy centers, especially in developing countries. It is known that human body is composed of fat, tissue, bones, and air cavities having different electron densities that influence the interaction of photon and electron energy deposition affecting the dose delivery to a target volume. Therefore, this study was conducted to develop an indigenous heterogeneous pelvic phantom similar to the patient’s anatomy and perform a pre-treatment verification in a realistic clinical scenario to obtain reproducible dosimetry.
A heterogeneous pelvic phantom was designed, shown in Figure 2, which was made of wax, a male pelvic bone (Figure 3), water, and borax powder. To construct the phantom, male pelvic bone with a density equivalent to that of human pelvic bone was placed in a cylindrical-shaped container. After placing it, a round plastic ball filled with water was placed for bladder. Borax powder with glue and water was placed below the bladder for rectum. Subsequently, molten wax was poured into it and allowed to solidify. After complete solidification of the wax, the outer container was cut and removed. A cavity was prepared at approximately geometrical center of phantom volume, and a 0.6 cm3 ion chamber was kept in the same position till the end of experiment, Figure 4. The three fiducially lead markers were put on two bilateral points, and one anterior point was placed on the surface of the phantom in the same cross-sectional plane to make three reference points [15].
Designed pelvic phantom.
Male pelvic and femur bone used in developed phantom.
CT slice of developed phantom with different parts.
Brivo CT 325 2-slice CT (Wipro GE Healthcare, WI, USA)) has been utilized for computed tomography (CT) of the phantom and the CT images were taken at a slice thickness of 3 mm for planning purposes. The CT images were imported into the treatment planning system. The width and height were measured using the length measuring tool available in Treatment Planning System (TPS). The mean width and height were measured as 29 cm and 25 cm in CT images of heterogeneous pelvic phantom, respectively. These geometries of the phantom show that it can accommodate delivered beam field sizes and shapes. It allows the establishment of 3D locations. It is easy to transport, set up, align, and takedown in an accurate and efficient manner.
Computed Tomography (CT) works on the principle of amount of the X-ray energy absorbed. The amount of X-ray energy absorbed is proportional to the density of the body tissue. The computer generates a grayscale image, where the tissue density is indicated by shades of gray. The Hounsfield Unit (HU) is a relative quantitative measurement of radio density used in the interpretation of computed tomography images. The Hounsfield unit was named after Sir Godfrey Hounsfield, recipient of the Nobel Prize, for the invention of Computed Tomography (CT) [16]. It is proportional to the degree of x-ray attenuation and is defined as:
where μ is the linear attenuation coefficient for water and tissue. On the Hounsfield scale, air is represented by a value of −1000 (black on the grayscale) and bone between +700 (cancellous bone) to +3000 (dense bone) (white on the grayscale). The linear attenuation coefficient is a function of both electron density and atomic number of the tissue within a pixel.
The electron density is the measure of the probability of an electron being present at a specific location. It is calculated from its mass density and its atomic composition.
The Hounsfield Unit (HU) and relative electron density of bone, fat, air cavity, bladder, and rectum in Computed Tomography (CT) images of a heterogeneous phantom and an actual patient were measured and has been given in Table 1. All the measurements were calculated by using Computed Tomography (CT) scanner console in terms of mean and stander deviation due to density variation in different CT slices. For the actual patient, a CT image of one patient was taken.
S.No. | Pelvic Organs | Material | In CT images of a heterogeneous phantom | In CT images of an actual patient | ||
---|---|---|---|---|---|---|
HU ± SD | Relative electron density | HU ± SD | Relative electron density | |||
1 | Bone | Male Pelvic Bone | 1037 ± 179 | 1.632 | 556 ± 187 | 1.335 |
2 | Fat | Wax | −162 ± 45 | 0.896 | −109 ± 108 | 0.955 |
3 | Air cavity | Air | −846 ± 143 | 0.159 | −847 ± 79 | 0.158 |
4 | Bladder | Water | −5 ± 5 | 1.037 | −3 ± 8 | 1.039 |
5 | Rectum | Borax Powder | 19 ± 53 | 1.051 | 20 ± 26 | 1.054 |
Comparison of Hounsfield units and relative electron densities of organs.
CT: Computed Tomography; HU: Hounsfield Units; SD: Standard Deviation.
According to the results obtained from the Computed Tomography (CT) images of a heterogeneous pelvic phantom, relative electron densities for bone, fat (wax), air cavity, bladder (water), and rectum (borax powder) were 1.632, 0.896, 0.159, 1.037, and 1.051, respectively. On the other hand, relative electron densities for bone, fat, air cavity, bladder, and rectum were 1.335, 0.955, 0.158, 1.039, and 1.054, respectively, in an actual patient Computed Tomography (CT) image.
Various Intensity Modulated Radiation Therapy (IMRT) plans for prostrate patients were generated on the Monaco planning system. Plans were created with 5, 7, 9, and 12 coplanar 6MV photon beams. Couch and collimator angles were kept as 0°for all plans. Calculation parameters such as grid spacing, fluence smoothing, and statistical uncertainty were 0.3 cm, medium, and 1% per plan respectively. Furthermore, the Monte Carlo algorithm was used for the plan optimization, and all the plans were generated in step and shoot mode.
The difference between measured and planned dose distribution is evaluated using quantitative evaluation methods. The Quality Assurance (QA) procedures of Treatment Planning System (TPS) narrated by Van Dyk et al. subdivides the dose distribution comparisons into high and low dose gradients regions, each with a different acceptance standard. In regions of low gradient, planned and measured doses are compared directly, with an acceptance tolerance placed on the difference between the measured and calculated doses. On the other hand, in high dose gradient regions, a small spatial error, either in measurement or calculation, results in a large dose difference between measurement and calculation. Therefore, in the region of high dose gradient, the concept of a Distance-To-Agreement (DTA) distribution is used to determine the acceptability of the dose calculation. The Distance-To-Agreement (DTA) is the distance between a measured data point and the nearest point in the calculated dose distribution exhibiting the same dose. The Dose-Difference (DD) and Distance-To-Agreement (DTA) evaluations complement each other when used as determinants of dose distribution calculation quality.
Two kinds of phantoms were chosen for absolute dosimetry of plans already done for the treatment. First one is heterogeneous pelvic phantom developed for radiotherapy quality assurance. Second one was Delta4 phantom (Scandidos, Uppsala, Sweden). CT scan of both the phantoms was done and images were transferred to the Monaco planning system.
After the complete optimization of the Intensity Modulated Radiation Therapy (IMRT), the plans were exported to a pelvic phantom and Delta4 phantom for a pre-treatment verification. After position verification, all Intensity Modulated Radiation Therapy (IMRT) plans were delivered by a linear accelerator.
There are various methods to achieve accuracy in dosimetry and they are based on International Atomic Energy Agency (IAEA) recommendations published in technical reports series number 277 [17] and 398 [18].
In this study, absorbed dose at reference depth was calculated according to the Technical Reports Series No. 398 (TRS398) of the International Atomic Energy Agency (IAEA) [18] using the relation:
where, MQ is the electrometer reading (charge), ND,W is the tor, kQ,Qo chamber specific factor, kT,P temperature–pressure correction factor, Kpol polarity correction factor, KS ion recombination factor.
The ND,W is the calibration factor in terms of absorbed dose to water for a dosimeter at a reference beam quality
The KQ,Qois a factor that corrects for the difference between the response of the ion chamber in the reference beam quality Qo used for calibrating the chamber and in the actual user beam quality Q. The subscript
The mass of air in the cavity volume is subject to atmospheric variations. The correction factor to be applied to convert the cavity air mass to the reference conditions is given by:
where, P and T are the cavity air pressure and temperature at the time of the measurements, and PO and TO be the reference values (generally 101.3 kPa and 20°C).
The polarity factor is used to correct the response of an ionization chamber for the effect of change in polarity of the polarizing voltage applied to the chamber. It can be accounted for, by using a correction factor
where, M+ and M− are the electrometer readings obtained at positive and negative polarity, respectively, and M is the electrometer reading obtained with the polarity used routinely (positive or negative).
The incomplete collection of charge in an ionization chamber cavity owing to the recombination of ions requires the use of correction factor ks.
where, ao = 2.337, a1 = −3.636, a2 = 2.299 and M1 and M2 are the electrometer readings at the polarizing voltages V1and V2, respectively, measured using the same irradiation conditions. V1 is the normal operating voltage and V2 is a lower voltage; the ratio V1/V2 is equal to two.
In a pelvic phantom, the dose for each plan was measured by PTW UNIDOS E electrometer connected with 0.6 cm3ion chambers using Eq. 1 according to International Atomic Energy Agency (IAEA) published, Technical Reports Series-398 (TRS 398) protocol. These measured doses were compared with doses planned on the treatment planning system (TPS).
For Delta4 phantom, TPS calculated dose fluence was compared with measured dose fluence using the gamma evaluation method with critically acceptable criteria of 3 mm Distance-To-Agreement (DTA) and 3% Dose-Difference (DD). Before the evaluation of an Intensity Modulated Radiation Therapy (IMRT) plan, two more measurements were done by delivering 100 cGy with a 10 × 10 cm field at gantry angles of 0° and 90° in order to check the phantom for positional corrections and linear accelerator output constancy.
Table 2 shows the planning parameters, including number of fields, segments, and monitor units, and the percentage variation between planned doses and measured doses for each test case using pelvic phantom.
Plan No. | Algorithm | Energy | No. of fields | Measured Dose | Planned Dose | % Variation |
---|---|---|---|---|---|---|
P1 | Monte Carlo | 6 MV | 5 | 190.34 | 185.8 | 2.44 (+) |
P2 | Monte Carlo | 6 MV | 7 | 202.15 | 207.5 | 2.58(−) |
P3 | Monte Carlo | 6 MV | 9 | 172.46 | 176.1 | 2.07(−) |
P4 | Monte Carlo | 6 MV | 12 | 194.57 | 191.84 | 1.42(+) |
Mean 2.13 | ||||||
SD 0.52 |
Percentage variation between planned dose on treatment planning system and measured dose on linear accelerator using heterogeneous pelvic phantom.
MV: Mega Voltage; SD: Standard deviation.
The gamma analysis results of each test case, including Dose-difference (DD), Distance-To-Agreement (DTA), and Gamma Index passing rates, are presented in Table 3.
Plan No. | Field Number | Segment Number | Monitor Unit | Dose Difference | DTA | Gamma Index |
---|---|---|---|---|---|---|
P1 | 5 | 14 | 734.20 | 79.5% | 97.9% | 98.4% |
P2 | 7 | 19 | 820.31 | 80.1% | 95.1% | 97.3% |
P3 | 9 | 15 | 775.48 | 81.4% | 94.3% | 97.5% |
P4 | 12 | 14 | 724.53 | 80.8% | 95.3% | 98.8% |
Result of dose difference, distance to agreement and gamma index using Delta4 phantom.
DTA: Distance to agreement.
The percentage variation between planned dose and measured dose was noted as 2.44% in an indigenously designed heterogeneous pelvic phantom.
Dose distribution at axial projection on the heterogeneous phantom, Delta4 phantom, and on actual patient CT image are shown in Figure 5a–c respectively.
(a) Dose distribution in heterogeneous phantom, CT slice for test case P1. (b) Dose distribution in Delta4 phantom, CT slice for test case P1. (c) Dose distribution in patient, CT slice for test case P1. (d) Dose distribution, dose deviation, distance to agreement and gamma index of test case P1.
The same plan was verified by using Delta4 phantom. The gamma passing rate for test P1 was 98.4%, whereas the pass percentages of Dose-Difference (DD) and Distance-To-Agreement (DTA) were 79.5% and 97.9%, respectively shown in Figure 5d.
The percentage variation between planned dose and measured dose was noted as 2.58% in the designed pelvic phantom.
The same plan was verified by using Delta4 phantom. The gamma passing rate for test P2 was 97.3%, whereas the pass percentages of Dose-Difference (DD) and Distance-To-Agreement (DTA) were 80.1% and 94.3%, respectively.
Similarly, with 9 coplanar beams, the percentage variation between planned dose and measured dose was noted as 2.07%.
The Dose-Difference (DD) and Distance-To-Agreement (DTA) and Gamma Index were 81.4%, 94.3%, and 97.5% respectively.
For the Intensity Modulated Radiation Therapy (IMRT) with 12 coplanar beams, the percentage variation between planned dose and measured dose was noted as 1.42%.
The Dose-Difference (DD) and Distance-To-Agreement (DTA) and Gamma Index were 80.8%, 95.3%, and 98.8%, respectively.
For all the four Intensity Modulated Radiation Therapy (IMRT) plans the percentage variation between the planned dose and measured dose was found to be within the tolerance limit (< ± 3%) prescribed by International Commission on Radiation Units and Measurements (ICRU 83) [19]. Additionally, Gamma evaluation results are based on the critically acceptable criteria of 3 mm DTA and 3% DD given in Table 3.
In radiation therapy, Quality Assurance (QA) is an essential aspect to ensure that the most accurate treatments are being delivered to a patient. When a new linear accelerator is commissioned at a hospital, the dosimetric parameters, for example, percentage depth dose, radiation beam symmetry, and flatness, are tested to verify the manufacturer’s specifications and recommended guidelines. The machine is then periodically tested on a daily, monthly, and yearly basis to make sure that it remains within the specifications. This ensures that the machine continues to deliver what is indicated by a plan. For simple, traditional treatment methods, the Quality Assurance at the machine level is sufficient because possible errors are considered to be acceptable. However, for Intensity-Modulated Radiotherapy and Volumetric Modulated Arc Therapy planned treatments, the increased complexity along with high dose gradients, result in dosimetric errors and require empirical testing.
The main goal of radiation therapy is to deliver a prescribed dose to a target while minimizing the dose to the surrounding normal tissue. As new techniques are developed to achieve this goal, the treatments become more complex and the importance of having accurate dosimetry methods for both initial systems commissioning and ongoing Quality Assurance (QA) increases. Currently, it is mandatory that a patient-specific quality assurance test be performed prior to each new treatment course. Therefore, this study was conducted to develop an indigenous heterogeneous pelvic phantom similar to patient anatomy and perform a pre-treatment verification in a realistic clinical scenario to obtain reproducible dosimetry. Very few heterogeneous phantoms which are available commercially e.g. anthropomorphic phantom are very costly, and are not procured by most radiotherapy centers, especially in low-budget centers in developing countries [20].
In this study, an indigenous heterogeneous phantom was developed using wax for fat, artificial pelvic bone for pelvic bone, water for bladder, and borax powder with glue for rectum. Hounsfield unit and relative electron density of the phantom for different materials used for mimicking the patient were compared with the actual patient pelvic region. A comparison of Hounsfield Unit and electron density shows that the material used for the construction of phantom is almost equal to the patient tissue heterogeneity as well as shape and tissue content. Materials used for the construction of phantom were locally available, cost-effective, and strong enough to maintain structural integrity.
In this study, Intensity Modulated Radiotherapy was verified using an indigenous heterogeneous pelvic phantom. For validation of heterogeneous phantom, similar plans were also verified using the Delta4 Phantom. The results obtained for all the studies were found to be within the tolerance limit which is <3% as prescribed by the International Commission of Radiation Protection (ICRU 83). This indicates that the phantom can be used successfully for routine patient-specific verification practices.
The company was founded in Vienna in 2004 by Alex Lazinica and Vedran Kordic, two PhD students researching robotics. While completing our PhDs, we found it difficult to access the research we needed. So, we decided to create a new Open Access publisher. A better one, where researchers like us could find the information they needed easily. The result is IntechOpen, an Open Access publisher that puts the academic needs of the researchers before the business interests of publishers.
",metaTitle:"Our story",metaDescription:"The company was founded in Vienna in 2004 by Alex Lazinica and Vedran Kordic, two PhD students researching robotics. While completing our PhDs, we found it difficult to access the research we needed. So, we decided to create a new Open Access publisher. A better one, where researchers like us could find the information they needed easily. The result is IntechOpen, an Open Access publisher that puts the academic needs of the researchers before the business interests of publishers.",metaKeywords:null,canonicalURL:"/page/our-story",contentRaw:'[{"type":"htmlEditorComponent","content":"We started by publishing journals and books from the fields of science we were most familiar with - AI, robotics, manufacturing and operations research. Through our growing network of institutions and authors, we soon expanded into related fields like environmental engineering, nanotechnology, computer science, renewable energy and electrical engineering, Today, we are the world’s largest Open Access publisher of scientific research, with over 4,200 books and 54,000 scientific works including peer-reviewed content from more than 116,000 scientists spanning 161 countries. Our authors range from globally-renowned Nobel Prize winners to up-and-coming researchers at the cutting edge of scientific discovery.
\\n\\nIn the same year that IntechOpen was founded, we launched what was at the time the first ever Open Access, peer-reviewed journal in its field: the International Journal of Advanced Robotic Systems (IJARS).
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\\n\\nWe started by publishing journals and books from the fields of science we were most familiar with - AI, robotics, manufacturing and operations research. Through our growing network of institutions and authors, we soon expanded into related fields like environmental engineering, nanotechnology, computer science, renewable energy and electrical engineering, Today, we are the world’s largest Open Access publisher of scientific research, with over 4,200 books and 54,000 scientific works including peer-reviewed content from more than 116,000 scientists spanning 161 countries. Our authors range from globally-renowned Nobel Prize winners to up-and-coming researchers at the cutting edge of scientific discovery.
\n\nIn the same year that IntechOpen was founded, we launched what was at the time the first ever Open Access, peer-reviewed journal in its field: the International Journal of Advanced Robotic Systems (IJARS).
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\n\n\r\n\tEducation and Human Development is an interdisciplinary research area that aims to shed light on topics related to both learning and development. This Series is intended for researchers, practitioners, and students who are interested in understanding more about these fields and their applications.
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His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"333824",title:"Dr.",name:"Ahmad Farouk",middleName:null,surname:"Musa",slug:"ahmad-farouk-musa",fullName:"Ahmad Farouk Musa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333824/images/22684_n.jpg",biography:"Dato’ Dr Ahmad Farouk Musa\nMD, MMED (Surgery) (Mal), Fellowship in Cardiothoracic Surgery (Monash Health, Aust), Graduate Certificate in Higher Education (Aust), Academy of Medicine (Mal)\n\n\n\nDato’ Dr Ahmad Farouk Musa obtained his Doctor of Medicine from USM in 1992. He then obtained his Master of Medicine in Surgery from the same university in the year 2000 before subspecialising in Cardiothoracic Surgery at Institut Jantung Negara (IJN), Kuala Lumpur from 2002 until 2005. He then completed his Fellowship in Cardiothoracic Surgery at Monash Health, Melbourne, Australia in 2008. He has served in the Malaysian army as a Medical Officer with the rank of Captain upon completing his Internship before joining USM as a trainee lecturer. He is now serving as an academic and researcher at Monash University Malaysia. He is a life-member of the Malaysian Association of Thoracic & Cardiovascular Surgery (MATCVS) and a committee member of the MATCVS Database. He is also a life-member of the College of Surgeons, Academy of Medicine of Malaysia; a life-member of Malaysian Medical Association (MMA), and a life-member of Islamic Medical Association of Malaysia (IMAM). Recently he was appointed as an Interim Chairperson of Examination & Assessment Subcommittee of the UiTM-IJN Cardiothoracic Surgery Postgraduate Program. As an academic, he has published numerous research papers and book chapters. He has also been appointed to review many scientific manuscripts by established journals such as the British Medical Journal (BMJ). He has presented his research works at numerous local and international conferences such as the European Association for Cardiothoracic Surgery (EACTS) and the European Society of Cardiovascular Surgery (ESCVS), to name a few. He has also won many awards for his research presentations at meetings and conferences like the prestigious International Invention, Innovation & Technology Exhibition (ITEX); Design, Research and Innovation Exhibition, the National Conference on Medical Sciences and the Annual Scientific Meetings of the Malaysian Association for Thoracic and Cardiovascular Surgery. He was awarded the Darjah Setia Pangkuan Negeri (DSPN) by the Governor of Penang in July, 2015.",institutionString:null,institution:{name:"Monash University Malaysia",country:{name:"Malaysia"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}}]}},subseries:{item:{id:"4",type:"subseries",title:"Fungal Infectious Diseases",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment",scope:"Fungi are ubiquitous and there are almost no non-pathogenic fungi. Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",hasOnlineFirst:!0,hasPublishedBooks:!1,annualVolume:11400,editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. 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