Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\n
This achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\n
We are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\n
Thank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"129",leadTitle:null,fullTitle:"Ventricular Assist Devices",title:"Ventricular Assist Devices",subtitle:null,reviewType:"peer-reviewed",abstract:"The assist devices will continue adding a large number of years of life to humans globally and empower the medical society to optimize heart failure therapy. While expensive and cumbersome task, the foundation provided in this book reflects a contemporary product of original research from a multitude of different experts in the field.\nWe hope this cumulative international effort provides the necessary tools for both the novice as well as the active practitioner aiming to change the outcome of these complex patients.",isbn:null,printIsbn:"978-953-307-164-0",pdfIsbn:"978-953-51-6431-9",doi:"10.5772/654",price:119,priceEur:129,priceUsd:155,slug:"ventricular-assist-devices",numberOfPages:224,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"2b6b9dbd504cdf6ed9c20a742e3f2a9d",bookSignature:"Jeffrey Shuhaiber",publishedDate:"April 26th 2011",coverURL:"https://cdn.intechopen.com/books/images_new/129.jpg",numberOfDownloads:47691,numberOfWosCitations:12,numberOfCrossrefCitations:3,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:11,numberOfDimensionsCitationsByBook:1,hasAltmetrics:0,numberOfTotalCitations:26,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 2nd 2010",dateEndSecondStepPublish:"June 30th 2010",dateEndThirdStepPublish:"October 5th 2010",dateEndFourthStepPublish:"December 4th 2010",dateEndFifthStepPublish:"February 17th 2011",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"22152",title:"Dr.",name:"Jeffrey",middleName:null,surname:"Shuhaiber",slug:"jeffrey-shuhaiber",fullName:"Jeffrey Shuhaiber",profilePictureURL:"https://mts.intechopen.com/storage/users/22152/images/system/22152.jpg",biography:"Jeffrey Shuhaiber is a cardiovascular and thoracic surgeon at the Heart and Vascular Center and Department of Surgery at Baystate Medical Center and University of Massachusetts Medical School. Dr. Shuhaiber earned his MD from the University of London King’s College School of Medicine with distinction and completed his post-graduate medical education at the same institution. He completed his surgical residency at the University of Illinois and then thoracic surgery at Loyola University, and did his fellowship at Boston Children’s Hospital and Cambridge University. He then joined the University of Cincinnati and Children’s Hospital as Assistant Professor in Cardiac Surgery. Dr. Shuhaiber has interests in both teaching and clinical research. He has received numerous awards throughout residency and clinical practice. He has had broad training in both acquired and structural heart disease as well as surgery for heart and lung failure. He has been the recipient of first-place awards for research presented at American College of Surgeons Committees. He is a reviewer for several surgical journals and has authored several book chapters, and has authored or coauthored numerous peer-reviewed publications. He performs both clinical and translational research.",institutionString:"University of Massachusetts Medical School",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"University of Massachusetts Medical School",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"983",title:"Cardiac Electrophysiology",slug:"cardiac-electrophysiology"}],chapters:[{id:"15745",title:"Indications for Ventricle Assist Devices",doi:"10.5772/15542",slug:"indications-for-ventricle-assist-devices",totalDownloads:5411,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Guillermo Reyes and Sara Badia",downloadPdfUrl:"/chapter/pdf-download/15745",previewPdfUrl:"/chapter/pdf-preview/15745",authors:[{id:"21175",title:"Dr.",name:"Guillermo",surname:"Reyes",slug:"guillermo-reyes",fullName:"Guillermo Reyes"},{id:"24003",title:"Dr.",name:"Sara",surname:"Badia",slug:"sara-badia",fullName:"Sara Badia"}],corrections:null},{id:"15746",title:"Echocardiographic Evaluation of Ventricular Assist Devices",doi:"10.5772/15000",slug:"echocardiographic-evaluation-of-ventricular-assist-devices",totalDownloads:6762,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"David Platts",downloadPdfUrl:"/chapter/pdf-download/15746",previewPdfUrl:"/chapter/pdf-preview/15746",authors:[{id:"19458",title:"Dr.",name:"David",surname:"Platts",slug:"david-platts",fullName:"David Platts"}],corrections:null},{id:"15747",title:"Altered Expression of mRNA and miRNA during Mechanical Support of the Failing Human Heart",doi:"10.5772/15981",slug:"altered-expression-of-mrna-and-mirna-during-mechanical-support-of-the-failing-human-heart",totalDownloads:2e3,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Marguérite E.I. Schipper, Sjoukje I. Lok, Hub Dullens, Joyce Van Kuik, Frits H.J. Gmelig-Meyling, Jaap Lahpor, Marc A. Vos, Arnoud Van Der Laarse, Nicolaas De Jonge, Matthijs F.M. Van Oosterhout and Roel A. De Weger",downloadPdfUrl:"/chapter/pdf-download/15747",previewPdfUrl:"/chapter/pdf-preview/15747",authors:[{id:"22747",title:"Dr.",name:"Roel",surname:"De Weger",slug:"roel-de-weger",fullName:"Roel De Weger"},{id:"22755",title:"Dr.",name:"Hub",surname:"Dullens",slug:"hub-dullens",fullName:"Hub Dullens"},{id:"22756",title:"B.Sc",name:"Joyce",surname:"Van Kuik",slug:"joyce-van-kuik",fullName:"Joyce Van Kuik"},{id:"22757",title:"Dr.",name:"Frits",surname:"Gmelig-Meyling",slug:"frits-gmelig-meyling",fullName:"Frits Gmelig-Meyling"},{id:"22758",title:"Dr.",name:"Jaap",surname:"Lahpor",slug:"jaap-lahpor",fullName:"Jaap Lahpor"},{id:"22759",title:"Dr.",name:"Marc",surname:"Vos",slug:"marc-vos",fullName:"Marc Vos"},{id:"22760",title:"Dr.",name:"Matthijs",surname:"van Oosterhout",slug:"matthijs-van-oosterhout",fullName:"Matthijs van Oosterhout"},{id:"22761",title:"Dr.",name:"Arnoud",surname:"van der Laarse",slug:"arnoud-van-der-laarse",fullName:"Arnoud van der Laarse"},{id:"22762",title:"Dr.",name:"Nicolaas",surname:"de jonge",slug:"nicolaas-de-jonge",fullName:"Nicolaas de jonge"}],corrections:null},{id:"15748",title:"Ventricular Assist Device – How to Obtain Optimal Benefits?",doi:"10.5772/15384",slug:"ventricular-assist-device-how-to-obtain-optimal-benefits-",totalDownloads:3411,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Agata Bielecka-Dabrowa, Maciej Banach, Jacek Rysz and Gerry O’Driscoll",downloadPdfUrl:"/chapter/pdf-download/15748",previewPdfUrl:"/chapter/pdf-preview/15748",authors:[{id:"20629",title:"Dr.",name:"Agata",surname:"Bielecka-Dabrowa",slug:"agata-bielecka-dabrowa",fullName:"Agata Bielecka-Dabrowa"},{id:"23242",title:"prof",name:"Maciej",surname:"Banach",slug:"maciej-banach",fullName:"Maciej Banach"},{id:"23243",title:"prof",name:"Jacek",surname:"Rysz",slug:"jacek-rysz",fullName:"Jacek Rysz"},{id:"23244",title:"prof",name:"Gerry",surname:"O'Driscoll",slug:"gerry-o'driscoll",fullName:"Gerry O'Driscoll"}],corrections:null},{id:"15749",title:"Cardiac Support and Multiorgan Dysfunction Syndrome",doi:"10.5772/15548",slug:"cardiac-support-and-multiorgan-dysfunction-syndrome",totalDownloads:2947,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Khurram Shahzad, Farhana Latif, Hirokazu Akashi, Tomoko S. Kato, Anshu Sinha, Duygu Onat and Mario C. Deng",downloadPdfUrl:"/chapter/pdf-download/15749",previewPdfUrl:"/chapter/pdf-preview/15749",authors:[{id:"19521",title:"Dr.",name:"hirokazu",surname:"akashi",slug:"hirokazu-akashi",fullName:"hirokazu akashi"},{id:"19560",title:"Prof.",name:"Mario",surname:"Deng",slug:"mario-deng",fullName:"Mario Deng"},{id:"19711",title:"Dr.",name:"Tomoko",surname:"Kato",slug:"tomoko-kato",fullName:"Tomoko Kato"},{id:"21186",title:"Dr.",name:"Khurram",surname:"Shahzad",slug:"khurram-shahzad",fullName:"Khurram Shahzad"},{id:"21189",title:"Dr.",name:"Farhana",surname:"Latif",slug:"farhana-latif",fullName:"Farhana Latif"},{id:"21190",title:"Dr.",name:"Anshu",surname:"Sinha",slug:"anshu-sinha",fullName:"Anshu Sinha"},{id:"21191",title:"Dr.",name:"Duygu",surname:"Onat",slug:"duygu-onat",fullName:"Duygu Onat"}],corrections:null},{id:"15750",title:"Future Treatment of Acute Cardiac Collapse - A Role for Percutaneous Circulatory Assist Devices",doi:"10.5772/15150",slug:"future-treatment-of-acute-cardiac-collapse-a-role-for-percutaneous-circulatory-assist-devices",totalDownloads:3017,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Vepgard Tuseth and Jan Erik Nordrehaug",downloadPdfUrl:"/chapter/pdf-download/15750",previewPdfUrl:"/chapter/pdf-preview/15750",authors:[{id:"19831",title:"Dr.",name:"Vegard",surname:"Tuseth",slug:"vegard-tuseth",fullName:"Vegard Tuseth"},{id:"24921",title:"Mr.",name:"Jan Erik",surname:"Nordrehaug",slug:"jan-erik-nordrehaug",fullName:"Jan Erik Nordrehaug"}],corrections:null},{id:"15751",title:"Initial Experience of Lower Limb Thermal Therapy for Patients with an Extracorporeal Left Ventricular Assist Device Awaiting Heart Transplantation",doi:"10.5772/15073",slug:"initial-experience-of-lower-limb-thermal-therapy-for-patients-with-an-extracorporeal-left-ventricula",totalDownloads:2178,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Kazuo Komamura",downloadPdfUrl:"/chapter/pdf-download/15751",previewPdfUrl:"/chapter/pdf-preview/15751",authors:[{id:"19651",title:"Dr.",name:"Kazuo",surname:"Komamura",slug:"kazuo-komamura",fullName:"Kazuo Komamura"}],corrections:null},{id:"15752",title:"Treatment of Ventricular Arrhythmias in Patients Undergoing LVAD Therapy",doi:"10.5772/16164",slug:"treatment-of-ventricular-arrhythmias-in-patients-undergoing-lvad-therapy",totalDownloads:5660,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Mulloy, Mahapatra S and Kern JA",downloadPdfUrl:"/chapter/pdf-download/15752",previewPdfUrl:"/chapter/pdf-preview/15752",authors:[{id:"23476",title:"Dr.",name:"John",surname:"Kern",slug:"john-kern",fullName:"John Kern"},{id:"62566",title:"Dr.",name:"Daniel P.",surname:"Mulloy",slug:"daniel-p.-mulloy",fullName:"Daniel P. Mulloy"},{id:"62567",title:"Dr.",name:"Srijoy",surname:"Mahapatra",slug:"srijoy-mahapatra",fullName:"Srijoy Mahapatra"}],corrections:null},{id:"15753",title:"Ventricular Assist Device-Specific Infections",doi:"10.5772/16020",slug:"ventricular-assist-device-specific-infections",totalDownloads:6979,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:null,signatures:"Sunil Pauwaa and Geetha Bhat",downloadPdfUrl:"/chapter/pdf-download/15753",previewPdfUrl:"/chapter/pdf-preview/15753",authors:[{id:"22813",title:"Dr.",name:"Geetha",surname:"Bhat",slug:"geetha-bhat",fullName:"Geetha Bhat"},{id:"22814",title:"Dr.",name:"Sunil",surname:"Pauwaa",slug:"sunil-pauwaa",fullName:"Sunil Pauwaa"}],corrections:null},{id:"15754",title:"Community Based Management of Ventricular Assist Devices",doi:"10.5772/intechopen.84010",slug:"community-based-management-of-ventricular-assist-devices",totalDownloads:3075,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Marnie Rodger and Vivek Rao",downloadPdfUrl:"/chapter/pdf-download/15754",previewPdfUrl:"/chapter/pdf-preview/15754",authors:[{id:"23297",title:"Ms",name:"Marnie",surname:"Rodger",slug:"marnie-rodger",fullName:"Marnie Rodger"}],corrections:null},{id:"15755",title:"Long-Term Management of Pulsatile Extracorporeal Left Ventricular Assist Device",doi:"10.5772/15118",slug:"long-term-management-of-pulsatile-extracorporeal-left-ventricular-assist-device",totalDownloads:3125,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Tomoko Sugiyama Kato, Kazuo Komamura, Noboru Oda, Taro Sasaoka, Ikutaro Nakajima, Ayako Tkakahashi and Masafumi Kitakaze",downloadPdfUrl:"/chapter/pdf-download/15755",previewPdfUrl:"/chapter/pdf-preview/15755",authors:[{id:"19711",title:"Dr.",name:"Tomoko",surname:"Kato",slug:"tomoko-kato",fullName:"Tomoko Kato"},{id:"19651",title:"Dr.",name:"Kazuo",surname:"Komamura",slug:"kazuo-komamura",fullName:"Kazuo Komamura"},{id:"22969",title:"Dr.",name:"Taro",surname:"Sasaoka",slug:"taro-sasaoka",fullName:"Taro Sasaoka"},{id:"22970",title:"Dr.",name:"Noboru",surname:"Oda",slug:"noboru-oda",fullName:"Noboru Oda"}],corrections:null},{id:"15756",title:"Outcomes Following Heart Transplantation among Those Bridged with VAD",doi:"10.5772/15832",slug:"outcomes-following-heart-transplantation-among-those-bridged-with-vad",totalDownloads:3127,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Jeffrey H. Shuhaiber",downloadPdfUrl:"/chapter/pdf-download/15756",previewPdfUrl:"/chapter/pdf-preview/15756",authors:[{id:"22152",title:"Dr.",name:"Jeffrey",surname:"Shuhaiber",slug:"jeffrey-shuhaiber",fullName:"Jeffrey Shuhaiber"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"8217",title:"Aortic Aneurysm and Aortic Dissection",subtitle:null,isOpenForSubmission:!1,hash:"cffb188ad7ddd3f31691c098dc8b9c73",slug:"aortic-aneurysm-and-aortic-dissection",bookSignature:"Jeffrey Shuhaiber",coverURL:"https://cdn.intechopen.com/books/images_new/8217.jpg",editedByType:"Edited by",editors:[{id:"22152",title:"Dr.",name:"Jeffrey",surname:"Shuhaiber",slug:"jeffrey-shuhaiber",fullName:"Jeffrey Shuhaiber"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"358",title:"Advances in Electrocardiograms",subtitle:"Methods and Analysis",isOpenForSubmission:!1,hash:"a61fed85204779463e6e483483601fdf",slug:"advances-in-electrocardiograms-methods-and-analysis",bookSignature:"Richard M. Millis",coverURL:"https://cdn.intechopen.com/books/images_new/358.jpg",editedByType:"Edited by",editors:[{id:"45295",title:"PhD.",name:"Richard",surname:"Millis",slug:"richard-millis",fullName:"Richard Millis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"23",title:"Modern Pacemakers",subtitle:"Present and Future",isOpenForSubmission:!1,hash:null,slug:"modern-pacemakers-present-and-future",bookSignature:"Mithilesh Kumar Das",coverURL:"https://cdn.intechopen.com/books/images_new/23.jpg",editedByType:"Edited by",editors:[{id:"61931",title:"Prof.",name:"Mithilesh",surname:"M Das",slug:"mithilesh-m-das",fullName:"Mithilesh M Das"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1734",title:"Cardiotoxicity of Oncologic Treatments",subtitle:null,isOpenForSubmission:!1,hash:"230472e71b2dd84c0a88f75165b37604",slug:"cardiotoxicity-of-oncologic-treatments",bookSignature:"Manuela Fiuza",coverURL:"https://cdn.intechopen.com/books/images_new/1734.jpg",editedByType:"Edited by",editors:[{id:"98648",title:"Prof.",name:"Manuela",surname:"Fiuza",slug:"manuela-fiuza",fullName:"Manuela Fiuza"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1291",title:"Advances in Electrocardiograms",subtitle:"Clinical Applications",isOpenForSubmission:!1,hash:"956bc1bdc0de1de4908abbee641a17aa",slug:"advances-in-electrocardiograms-clinical-applications",bookSignature:"Richard M. Millis",coverURL:"https://cdn.intechopen.com/books/images_new/1291.jpg",editedByType:"Edited by",editors:[{id:"45295",title:"PhD.",name:"Richard",surname:"Millis",slug:"richard-millis",fullName:"Richard Millis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7445",title:"Cardiotoxicity",subtitle:null,isOpenForSubmission:!1,hash:"90d1dca21a942e95b62075a222238625",slug:"cardiotoxicity",bookSignature:"Wenyong Tan",coverURL:"https://cdn.intechopen.com/books/images_new/7445.jpg",editedByType:"Edited by",editors:[{id:"192949",title:"Dr.",name:"Wenyong",surname:"Tan",slug:"wenyong-tan",fullName:"Wenyong Tan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"312",title:"New Aspects of Ventricular Assist Devices",subtitle:null,isOpenForSubmission:!1,hash:"1e87f2ee94ce52fb291dfcaaeb0dd147",slug:"new-aspects-of-ventricular-assist-devices",bookSignature:"Guillermo Reyes",coverURL:"https://cdn.intechopen.com/books/images_new/312.jpg",editedByType:"Edited by",editors:[{id:"21175",title:"Dr.",name:"Guillermo",surname:"Reyes",slug:"guillermo-reyes",fullName:"Guillermo Reyes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"290",title:"Cardiac Pacemakers",subtitle:"Biological Aspects, Clinical Applications and Possible Complications",isOpenForSubmission:!1,hash:"d336ffc14d9ab1745072534d4448305f",slug:"cardiac-pacemakers-biological-aspects-clinical-applications-and-possible-complications",bookSignature:"Mart Min",coverURL:"https://cdn.intechopen.com/books/images_new/290.jpg",editedByType:"Edited by",editors:[{id:"62780",title:"Prof.",name:"Mart",surname:"Min",slug:"mart-min",fullName:"Mart Min"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5764",title:"Interpreting Cardiac Electrograms",subtitle:"From Skin to Endocardium",isOpenForSubmission:!1,hash:"643f7c4a2e6b3307a7bcfed8f752836f",slug:"interpreting-cardiac-electrograms-from-skin-to-endocardium",bookSignature:"Kevin A. Michael",coverURL:"https://cdn.intechopen.com/books/images_new/5764.jpg",editedByType:"Edited by",editors:[{id:"61996",title:"Dr.",name:"Kevin",surname:"Michael",slug:"kevin-michael",fullName:"Kevin Michael"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5239",title:"Cholesterol Lowering Therapies and Drugs",subtitle:null,isOpenForSubmission:!1,hash:"c0db17451da651dc6ff8e6c13e9e177a",slug:"cholesterol-lowering-therapies-and-drugs",bookSignature:"Chunfa Huang and Carl Freter",coverURL:"https://cdn.intechopen.com/books/images_new/5239.jpg",editedByType:"Edited by",editors:[{id:"178352",title:"Dr.",name:"Chunfa",surname:"Huang",slug:"chunfa-huang",fullName:"Chunfa Huang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"73132",slug:"corrigendum-to-soil-erosion-influencing-factors-in-the-semiarid-area-of-northern-shaanxi-province-ch",title:"Corrigendum to: Soil Erosion Influencing Factors in the Semiarid Area of Northern Shaanxi Province, China",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/73132.pdf",downloadPdfUrl:"/chapter/pdf-download/73132",previewPdfUrl:"/chapter/pdf-preview/73132",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/73132",risUrl:"/chapter/ris/73132",chapter:{id:"72647",slug:"soil-erosion-influencing-factors-in-the-semiarid-area-of-northern-shaanxi-province-china",signatures:"Ning Ai, Qingke Zhu, Guangquan Liu and Tianxing Wei",dateSubmitted:"February 25th 2020",dateReviewed:"May 22nd 2020",datePrePublished:"June 29th 2020",datePublished:"March 24th 2021",book:{id:"8937",title:"Soil Moisture Importance",subtitle:null,fullTitle:"Soil Moisture Importance",slug:"soil-moisture-importance",publishedDate:"March 24th 2021",bookSignature:"Ram Swaroop Meena and Rahul Datta",coverURL:"https://cdn.intechopen.com/books/images_new/8937.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"315343",title:"Dr.",name:"Ram Swaroop",middleName:null,surname:"Meena",slug:"ram-swaroop-meena",fullName:"Ram Swaroop Meena"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"319114",title:"Ph.D.",name:"Ning",middleName:null,surname:"Ai",fullName:"Ning Ai",slug:"ning-ai",email:"aining_office@126.com",position:null,institution:{name:"China Institute of Water Resources and Hydropower Research",institutionURL:null,country:{name:"China"}}},{id:"319299",title:"Prof.",name:"Tianxing",middleName:null,surname:"Wei",fullName:"Tianxing Wei",slug:"tianxing-wei",email:"weitianxing925@126.com",position:null,institution:{name:"Beijing Forestry University",institutionURL:null,country:{name:"China"}}},{id:"319300",title:"Prof.",name:"Qingke",middleName:null,surname:"Zhu",fullName:"Qingke Zhu",slug:"qingke-zhu",email:"xiangmub@126.com",position:null,institution:{name:"Beijing Forestry University",institutionURL:null,country:{name:"China"}}},{id:"319301",title:"Prof.",name:"Guangquan",middleName:null,surname:"Liu",fullName:"Guangquan Liu",slug:"guangquan-liu",email:"gqliu@iwhr.com",position:null,institution:{name:"China Institute of Water Resources and Hydropower Research",institutionURL:null,country:{name:"China"}}}]}},chapter:{id:"72647",slug:"soil-erosion-influencing-factors-in-the-semiarid-area-of-northern-shaanxi-province-china",signatures:"Ning Ai, Qingke Zhu, Guangquan Liu and Tianxing Wei",dateSubmitted:"February 25th 2020",dateReviewed:"May 22nd 2020",datePrePublished:"June 29th 2020",datePublished:"March 24th 2021",book:{id:"8937",title:"Soil Moisture Importance",subtitle:null,fullTitle:"Soil Moisture Importance",slug:"soil-moisture-importance",publishedDate:"March 24th 2021",bookSignature:"Ram Swaroop Meena and Rahul Datta",coverURL:"https://cdn.intechopen.com/books/images_new/8937.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"315343",title:"Dr.",name:"Ram Swaroop",middleName:null,surname:"Meena",slug:"ram-swaroop-meena",fullName:"Ram Swaroop Meena"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"319114",title:"Ph.D.",name:"Ning",middleName:null,surname:"Ai",fullName:"Ning Ai",slug:"ning-ai",email:"aining_office@126.com",position:null,institution:{name:"China Institute of Water Resources and Hydropower Research",institutionURL:null,country:{name:"China"}}},{id:"319299",title:"Prof.",name:"Tianxing",middleName:null,surname:"Wei",fullName:"Tianxing Wei",slug:"tianxing-wei",email:"weitianxing925@126.com",position:null,institution:{name:"Beijing Forestry University",institutionURL:null,country:{name:"China"}}},{id:"319300",title:"Prof.",name:"Qingke",middleName:null,surname:"Zhu",fullName:"Qingke Zhu",slug:"qingke-zhu",email:"xiangmub@126.com",position:null,institution:{name:"Beijing Forestry University",institutionURL:null,country:{name:"China"}}},{id:"319301",title:"Prof.",name:"Guangquan",middleName:null,surname:"Liu",fullName:"Guangquan Liu",slug:"guangquan-liu",email:"gqliu@iwhr.com",position:null,institution:{name:"China Institute of Water Resources and Hydropower Research",institutionURL:null,country:{name:"China"}}}]},book:{id:"8937",title:"Soil Moisture Importance",subtitle:null,fullTitle:"Soil Moisture Importance",slug:"soil-moisture-importance",publishedDate:"March 24th 2021",bookSignature:"Ram Swaroop Meena and Rahul Datta",coverURL:"https://cdn.intechopen.com/books/images_new/8937.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"315343",title:"Dr.",name:"Ram Swaroop",middleName:null,surname:"Meena",slug:"ram-swaroop-meena",fullName:"Ram Swaroop Meena"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11861",leadTitle:null,title:"Redefining Standard Model Particle Physics",subtitle:null,reviewType:"peer-reviewed",abstract:"
\r\n\tToday, scientists describe the Universe mainly in terms of two theories: (1) Einstein's general theory of relativity (GTR), which describes the force of gravity and the large-scale structure of the Universe, and (2) quantum mechanics (QM), which describes the physics of the very small. However, as emphasized by Stephen Hawking and others, these two theories are known to be inconsistent with each other, so one needs to accommodate the gravitational force within the domain of QM by developing a quantum theory of gravity that will apply to both the large and small scales of the Universe. In a recent book entitled "The God Equation: The Quest for a Theory of Everything, Michio Kaku discusses the history and the nature of such a theory, which made significant progress during the 20th century through the development of the Standard Model (SM) of particle physics that represented the best understanding of the subatomic world at that time. Unfortunately, the SM makes no mention of the gravitational force. However, by removing several dubious assumptions made during the development of the SM, an alternative model, the Generation Model (GM), was developed from 2002-to 2019. The GM proposes that the gravitational force is not a fundamental force, as believed for centuries, but is a universal attractive, very weak residual interaction of the strong nuclear force, acting between the three massive particles, the proton, the neutron, and the electron, which are the constituents of a body of ordinary matter: this residual force provides a quantum theory of gravity. The main aim of this book is to discuss both the flaws of the SM and the GTR and also the considerable successes of the GM.
",isbn:"978-1-83768-018-4",printIsbn:"978-1-83768-017-7",pdfIsbn:"978-1-83768-019-1",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"085d4f6e00016fdad598675f825d6775",bookSignature:"Prof. Brian Albert Robson",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11861.jpg",keywords:"Standard Model, Twelve Elementary Particles, Higgs Boson Research, Universal Weak Force, CP-Violating Research, Big Bang Theory, Dark Matter, Dark Energy, Modified Gravity, Massless Elementary Particles, Quarks in Hadrons, Mixed Parity States",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 10th 2022",dateEndSecondStepPublish:"June 7th 2022",dateEndThirdStepPublish:"August 6th 2022",dateEndFourthStepPublish:"October 25th 2022",dateEndFifthStepPublish:"December 24th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"13 days",secondStepPassed:!1,areRegistrationsClosed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"A pioneering researcher in theoretical nuclear physics and the scattering of polarized particles, recognized by Marquis Who’s Who Top Scientists for achievements and leadership in education and research. More recently, developed the Generation Model as a successful alternative to the Standard Model of particle physics. This model led to a fully quantum theory of gravity. Dr. Robson is a member of the editorial board for the Scientific World Journal and the Open Nuclear and Particle Physics Journal.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"102886",title:"Prof.",name:"Brian Albert",middleName:null,surname:"Robson",slug:"brian-albert-robson",fullName:"Brian Albert Robson",profilePictureURL:"https://mts.intechopen.com/storage/users/102886/images/system/102886.jpeg",biography:"Professor Brian Albert Robson obtained MSc, PhD and DSc degrees in Physics from the University of Melbourne, Australia. He is a Fellow of both the Australian Institute of Physics and the UK Institute of Physics. Currently he is an Honorary Professor in the Research School of Physics, The Australian National University, Canberra. During his academic career, he served for four years as Officer-in-Charge of the Australian National University’s first computer, for nine years as Head of the Department of Theoretical Physics, and for two years as Associate Director of the Research School of Physics and Engineering. Professor Robson has published more than 150 scientific publications mainly in the areas of nuclear physics, particle physics, gravitation and cosmology.",institutionString:"The Australian National University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Australian National University",institutionURL:null,country:{name:"Australia"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"20",title:"Physics",slug:"physics"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"466998",firstName:"Dragan",lastName:"Miljak",middleName:"Anton",title:"Mr.",imageUrl:"https://mts.intechopen.com/storage/users/466998/images/21564_n.jpg",email:"dragan@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copy-editing and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. A unique name with a unique work ethic right at your service."}},relatedBooks:[{type:"book",id:"8356",title:"Metastable, Spintronics Materials and Mechanics of Deformable Bodies",subtitle:"Recent Progress",isOpenForSubmission:!1,hash:"1550f1986ce9bcc0db87d407a8b47078",slug:"solid-state-physics-metastable-spintronics-materials-and-mechanics-of-deformable-bodies-recent-progress",bookSignature:"Subbarayan Sivasankaran, Pramoda Kumar Nayak and Ezgi Günay",coverURL:"https://cdn.intechopen.com/books/images_new/8356.jpg",editedByType:"Edited by",editors:[{id:"190989",title:"Dr.",name:"Subbarayan",surname:"Sivasankaran",slug:"subbarayan-sivasankaran",fullName:"Subbarayan Sivasankaran"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"65719",title:"The Discrete Hankel Transform",doi:"10.5772/intechopen.84399",slug:"the-discrete-hankel-transform",body:'\n
\n
1. Introduction
\n
The Hankel transform has seen applications in many areas of science and engineering. For example, there are applications in propagation of beams and waves, the generation of diffusion profiles and diffraction patterns, imaging and tomographic reconstructions, designs of beams, boundary value problems, etc. The Hankel transform also has a natural relationship to the Fourier transform since the Hankel transform of zeroth order is a 2D Fourier transform of a rotationally symmetric function. Furthermore, the Hankel transform also appears naturally in defining the 2D Fourier transform in polar coordinates and the spherical Hankel transform also appears in the definition of the 3D Fourier transform in spherical polar coordinates [1, 2].
\n
As useful as the Hankel transform may be, there is no discrete Hankel transform (DHT) that exists that has the same relationship to the continuous Hankel transform in the same way that the discrete Fourier transform (DFT) exists alongside the continuous Fourier transform. By this, we mean that the discrete transform exists as a transform in its own right, has its own mathematical theory of the manipulated quantities, and finally as an added bonus, can be used to approximate the continuous version of the transform, with relevant sampling and interpolation theories. Until recently, a discrete Hankel transform merely implied an attempt to discretize the integral(s) of the continuous Hankel transform, rather than an independent discrete transform in its own right.
\n
Such a theory of a DHT was recently proposed [3]. Thus, goal of this chapter is to outline the mathematical theory for the DHT. The mathematical standard set of “DFT-like” rules of shift, modulation, multiplication and convolution rules are derived and presented. A Parseval-like theorem is presented, as are sampling and interpolation theorems. The manner in which this DHT can be used to approximate the continuous Hankel transform is also explained.
\n
\n
\n
2. Hankel transforms and Bessel series
\n
To start, we define the Hankel transform and Fourier-Bessel series as used in this work.
\n
\n
2.1 Hankel transform
\n
The nth-order Hankel transform \n\nF\n\nρ\n\n\n of the function \n\nf\n\nr\n\n\n of a real variable, \n\nr\n≥\n0\n\n, is defined by the integral [4]
where \n\n\nJ\nn\n\n\nz\n\n\n is the nth-order Bessel function of the first kind. If n is real and \n\nn\n>\n−\n1\n/\n2\n\n, the transform is self-reciprocating and the inversion formula is given by
Thus, Hankel transforms take functions in the spatial r domain and transform them to functions in the spatial frequency \n\nρ\n\n domain \n\nf\n\nr\n\n⇔\nF\n\nρ\n\n\n. The notation\n\n⇔\n\nis used to indicate a Hankel transform pair.
\n
\n
\n
2.2 Fourier Bessel series
\n
It is known that functions defined on a finite portion of the real line \n\n\n0\nR\n\n\n, can be expanded in terms of a Fourier Bessel series [5] given by
where the order, n, of the Bessel function is arbitrary and \n\n\nj\nnk\n\n\n denotes the kth root of the nth Bessel function \n\n\nJ\nn\n\n\nz\n\n\n. The Fourier Bessel coefficients \n\n\nf\nk\n\n\n of the function \n\nf\n\nr\n\n\n are given by
Eqs. (3) and (4) can be considered to be a transform pair where the continuous function \n\nf\n\nr\n\n\n is forward-transformed to the discrete vector \n\n\nf\nk\n\n\n given in (4). The inverse transform is then the operation which returns \n\nf\n\nr\n\n\n if given \n\n\nf\nk\n\n\n, and is given by the summation in Eq. (3). The Fourier Bessel series has the same relationship to the Hankel transform as the Fourier series has to the Fourier transform.
\n
\n
\n
\n
3. Sampling and interpolation theorems for band-limited and space-limited functions
\n
Sampling and interpolation theorems supply the answers to some important questions. For example, given a bandlimited function in frequency space, a sampling theorem answers the question of which samples of the original function are required in order to determine the function completely. The interpolation theorem shows how to interpolate those samples to recover the original function completely. Here, a band-limit means boundedness in frequency. In many applications such as tomography, the notion of a band-limit is not necessarily a property of a function, but rather a limitation of the measurement equipment used to acquire measurements. These measurements are then used to reconstruct some desired function. Thus, the sampling theorem can also answer the question of how band-limits (frequency sensitivities) of measurement equipment determine the resolution of those measurements.
\n
Given a space-limited function, the sampling theorem answers the question of which samples in frequency space determine the function completely, i.e., those that are required to reconstruct the original function. In other words, the sampling theorem dictates which frequency measurements need to be made. As before, the interpolation theorem will give a formula for interpolating those samples to reconstruct the continuous function completely.
\n
\n
3.1 Sampling theorem for a band-limited function
\n
We state here the sampling theorem in the same way that Shannon stated it for functions in time and frequency: if a spatial function \n\nf\n\nr\n\n\n contains no frequencies higher than \n\nW\n\n cycles per meter, then it is completely determined by a series of sampling points given by evaluating \n\nf\n\nr\n\n\n at \n\nr\n=\n\n\nj\nnk\n\n\nW\nρ\n\n\n\n where \n\n\nW\nρ\n\n=\n2\nπW\n\n.
\n
Proof: suppose that a function \n\nf\n\nr\n\n\n is band-limited in the frequency Hankel domain so that its spectrum \n\nF\n\nρ\n\n\n is zero outside of an interval \n\n\n0\n\n2\nπW\n\n\n\n. The interval is written in this form since \n\nW\n\n would typically be quoted in units of Hz (cycles per second) if using temporal units or cycles per meter if using spatial units. Therefore, the multiplication by \n\n2\nπ\n\n ensures that the final units are in \n\n\ns\n\n−\n1\n\n\n\n or \n\n\nm\n\n−\n1\n\n\n\n. Let us define \n\n\nW\nρ\n\n=\n2\nπW\n\n. Since the Hankel transform \n\nF\n\nρ\n\n\n is defined on a finite portion of the real line \n\n\n0\n\nW\nρ\n\n\n\n, it can be expanded in terms of a Fourier Bessel series as
In (6), we have used the fact that \n\nf\n\nr\n\n\n can be written in terms of its inverse Hankel transform, Eq. (2), in combination with the fact that the function is assumed band-limited.
\n
Hence, a function bandlimited to \n\n\n0\n\nW\nρ\n\n\n\n can be written as
Eq. (7) states that the samples \n\nf\n\n\n\nj\nnk\n\n\nW\nρ\n\n\n\n\n determine the function \n\nf\n\nr\n\n\n completely since (i) \n\nF\n\nρ\n\n\n is determined by Eq. (7), and (ii) \n\nf\n\nr\n\n\n is known if \n\nF\n\nρ\n\n\n is known. Another way of looking at this is that band-limiting a function to \n\n\n0\n\nW\nρ\n\n\n\n results in information about the original function at samples \n\n\nr\nnk\n\n=\n\n\nj\nnk\n\n\nW\nρ\n\n\n\n. So, Eq. (7) is the statement of the sampling theorem.
\n
To verify that this sampling theorem is consistent with expectations, we recognize that the zeros of \n\n\nJ\nn\n\n\nz\n\n\n are almost evenly spaced at intervals of \n\nπ\n\n and that the spacing becomes exactly \n\nπ\n\n in the limit as \n\nz\n→\n∞\n\n. To determine the (bandlimited) function \n\nf\n\nr\n\n\n completely, we need to sample the function at \n\nf\n\n\n\nj\nnk\n\n\nW\nρ\n\n\n\n=\nf\n\n\n\nj\nnk\n\n\n2\nπW\n\n\n\n\n and these samples are (eventually) multiples of \n\n\nπ\n\n(\n2\nπ\nW\n)\n\n\n=\n\n1\n\n(\n2\nW\n)\n\n\n\n apart, which is consistent with the standard Shannon sampling theorem which requires samples at multiples of \n\n\n1\n\n(\n2\nW\n)\n\n\n\n [6].
\n
\n
\n
3.2 Interpolation theorem for a band-limited function
\n
It follows from Eq. (7) that \n\nf\n\nr\n\n\n can be found by inverse Hankel transformation to give
Eq. (10) gives the formula for interpolating the samples \n\nf\n\n\n\nj\nnk\n\n\nW\nρ\n\n\n\n\n to reconstruct the continuous band-limited function \n\nf\n\nr\n\n\n. Each term used to reconstruct the original function \n\nf\n\nr\n\n\n consists of the samples of the function \n\nf\n\nr\n\n\n at \n\nr\n=\n\n\n\nj\nnk\n\n\nW\nρ\n\n\n\n\n multiplied by a reconstructing function of the form
In other research work [8], the generalized shift operator \n\n\nR\n\nr\n0\n\n\n\n indicating a shift of \n\n\nr\n0\n\n\n acting on the function \n\nf\n\nr\n\n\n has been defined by the formula
With this definition of a generalized shift operator, we recognize the integral in Eq. (12) as the inverse Hankel transform of the Boxcar function shifted by \n\n\n\n\nj\nnk\n\n\nW\nρ\n\n\n\n\n. More explicitly,
The boxcar function is a generalized version of the standard Rect function. The Rect function is usually defined as the function which has value 1 over the interval \n\n\n\n−\n1\n/\n2\n\n\n−\n1\n/\n2\n\n\n\n and is zero otherwise. Now this is interesting specifically because of the interpretation of Eq. (14). Had we been working in the standard Fourier domain instead of the Hankel domain, the Boxcar function would be replaced with the Rect function and the Hankel transform would be replaced with a standard Fourier transform. Proceeding with this line of thinking, the inverse Fourier transform of the Rect function would be a sinc function, which is the standard interpolation function of the classical Shannon interpolation formula. Hence, the Fourier equivalent interpretation of Eq. (14) is a shifted sinc function. Thus, the formulation above follows exactly the standard Shannon Interpolation formula (see the original publication [9], or the classic paper reprint [6]).
\n
For the relatively simple case of the zeroth-order Hankel transform, the inverse Hankel transform of the Boxcar function is given by
The function \n\n\n\n2\n\nJ\n1\n\n\nr\n\n\nr\n\n\n is often termed the jinc or sombrero function and is the polar coordinate analog of the sinc function, so Eq. (16) is a scaled version of a jinc function.
\n
In fact, from Eqs. (13), (14) and (16), it follows that the generalized shifted version of the jinc function is given by
Eq. (18) says that the interpolating function is a shifted jinc function, in analogy with a scaled sinc being the interpolating function for the sampling theorem used for Fourier transforms.
\n
\n
\n
3.4 Sampling theorem for a space-limited function
\n
Now consider a space-limited function \n\nf\n\nr\n\n\n so that \n\nf\n\nr\n\n\n is zero outside of an interval \n\n\n0\nR\n\n\n. It then follows that it can be expanded on \n\n\n0\nR\n\n\n in terms of a Fourier Bessel series so that
Here, we have used the definition of the Hankel transform \n\nF\n\nρ\n\n\n, Eq. (1), in the right hand side of Eq. (20). Hence, the function can be written as
From Eq. (21), it is evident that the samples \n\nF\n\n\n\nj\nnk\n\nR\n\n\n\n determine the function \n\nf\n\nr\n\n\n and hence its transform \n\nF\n\nρ\n\n\n completely. Another way of looking at this is that space limiting a function to \n\n\n0\nR\n\n\n implies discretization in spatial frequency space, at frequencies \n\n\nρ\nnk\n\n=\n\n\nj\nnk\n\nR\n\n\n.
\n
\n
\n
3.5 Interpolation theorem for a space-limited function
\n
The Hankel transform of the function can then be found from a forward Hankel transformation as
Eq. (23) gives the formula for interpolating the samples \n\nF\n\n\n\nj\nnk\n\nR\n\n\n\n to give the continuous function \n\nF\n\nρ\n\n\n.
\n
\n
\n
\n
4. Intuitive discretization scheme for the Hankel transform
\n
Based on the sampling theorems above, in this section we explore how assuming that a function can be simultaneously band-limited and space-limited will naturally lead to a discrete Hankel transform. Although it is known that it is not possible to fulfill both of these conditions exactly, it is possible to keep the spectrum within a given frequency band, and to have the space function very small outside some specified spatial interval (or vice-versa). Hence, it is possible for functions to be “effectively” space and band-limited.
\n
\n
4.1 Forward transform
\n
We demonstrated above that a band-limited function, with \n\nρ\n<\n\nW\nρ\n\n=\n2\nπW\n\n can be written as
Evaluating the previous Eq. (24) at the sampling points \n\n\nρ\nnm\n\n=\n\n\n\nj\nnm\n\n\nW\nρ\n\n\n\nj\nnN\n\n\n\n (for any integer N) gives for \n\nm\n<\nN\n\n
For \n\nm\n<\nN\n\n, then \n\n\nρ\nnm\n\n=\n\n\n\nj\nnm\n\n\nW\nρ\n\n\n\nj\nnN\n\n\n<\n\nW\nρ\n\n\n, and Eq. (25), summing over infinite k, is exact. For \n\nm\n≥\nN\n\n, then \n\n\nρ\nnm\n\n=\n\n\n\nj\nnm\n\n\nW\nρ\n\n\n\nj\nnN\n\n\n≥\n\nW\nρ\n\n\n and by the assumption of the bandlimited nature of the function, \n\nF\n\n\nρ\nnm\n\n\n=\n0\n\n.
\n
Now, suppose that in addition to being band-limited, the function is also effectively space limited. As mentioned above, it is known that a function cannot be finite in both space and spatial frequency (equivalently it cannot be finite in both time and frequency if using the Fourier transform). However, if a function is effectively space limited, this means that there exists an integer N for which \n\nf\n\n\n\nj\nnk\n\n\nW\nρ\n\n\n\n≈\n0\n\n for \n\nk\n>\nN\n\n. In other words, we can find an interval beyond which the space function is very small. In fact, since the Fourier-Bessel series in (24) is known to converge, it is known that \n\n\nlim\n\nk\n→\n∞\n\n\nf\n\n\n\nj\nnk\n\n\nW\nρ\n\n\n\n=\n0\n\n, which means that for any arbitrarily small \n\nε\n\n, there must exist an integer N for which \n\nf\n\n\n\nj\nnk\n\n\nW\nρ\n\n\n\n<\nε\n\n for \n\nk\n>\nN\n\n.
\n
Hence, using the argument of “effectively space limited” in the preceding paragraph, we can terminate the series in Eq. (25) at a suitably chosen \n\nN\n\n that ensures the effective space limit. Terminating the series at \n\nk\n=\nN\n\n is the same as assuming that \n\nf\n\nr\n\n≈\n0\n\n for \n\nr\n>\nR\n=\n\n\nj\nnN\n\n\nW\nρ\n\n\n\n. Noting that at \n\nk\n=\nN\n\n, the last term in (25) is \n\n\nJ\nn\n\n\n\n\n\nj\nnN\n\n\nj\nnm\n\n\n\nj\nnN\n\n\n\n=\n\nJ\nn\n\n\n\nj\nnm\n\n\n=\n0\n\n, then after terminating at N, Eq. (25) becomes for \n\nm\n=\n1\n.\n.\nN\n−\n1\n\n
In this case, the truncated sum in Eq. (26) does not represent \n\nF\n\n\nρ\nnm\n\n\n\nexactly due to the truncation at N terms, but should provide a reasonably good approximation since the Fourier-Bessel series is known to converge and we are assuming that we have terminated the series at the point where additional \n\nf\n\n\n\nj\nnk\n\n\nW\nρ\n\n\n\n\n terms do not contribute significantly.
\n
\n
\n
4.2 Inverse transform
\n
Concomitantly, we know that for any space-limited function then for \n\nr\n<\nR\n\n, we can write
More specifically, suppose that we follow the logic from the previous section that the function \n\nf\n\nr\n\n\n that was bandlimited but also “effectively space-limited” due the truncation of the series in Eq. (25) at N. In that case then \n\nR\n=\n\n\nj\nnN\n\n\nW\nρ\n\n\n\n and the band-limit implies that \n\nF\n\nρ\n\n=\n0\n\n for \n\nρ\n>\n\nW\nρ\n\n\n. Following this logic and using \n\nR\n=\n\n\nj\nnN\n\n\nW\nρ\n\n\n\n, then Eq. (27) becomes
where we truncated the series in Eq. (28) at N by using the fact that \n\nF\n\nρ\n\n=\n0\n\n for \n\nρ\n≥\n\nW\nρ\n\n\n to deduce that \n\nF\n\n\n\n\nj\nnm\n\n\nW\nρ\n\n\n\nj\nnN\n\n\n\n=\n0\n\n for \n\nm\n≥\nN\n\n. Evaluating (28) at \n\n\nr\nnk\n\n=\n\n\n\nj\nnk\n\nR\n\n\nj\nnN\n\n\n=\n\n\nj\nnk\n\n\nW\nρ\n\n\n\n gives for \n\nk\n=\n1\n.\n.\nN\n−\n1\n\n
Eqs. (29) and (30) are the fundamental relations used for the discrete Hankel transform proposed in the following sections.
\n
\n
\n
4.3 Intuitive discretization scheme and kernel
\n
The preceding development shows that a “natural,” N-dimensional discretization scheme in finite space \n\n\n0\nR\n\n\n and finite frequency space \n\n\n0\n\nW\nρ\n\n\n\n is given by
The relationship \n\n\nW\nρ\n\nR\n=\n\nj\nnN\n\n\n can be used to change from finite frequency domain to a finite space domain and vice-versa. The size of the transform N, can be determined from \n\n\nW\nρ\n\nR\n=\n\nj\nnN\n\n\n.
\n
It is pointed out in [10] that the zeros of \n\n\nJ\nn\n\n\nz\n\n\n are almost evenly spaced at intervals of \n\nπ\n\n and that the spacing becomes exactly \n\nπ\n\n in the limit as \n\nz\n→\n∞\n\n. In fact, it is shown in [10] that a simple asymptotic form for the Bessel function is given by
Eq. (32) becomes a better approximation to \n\n\nJ\nn\n\n\nz\n\n\n as \n\nz\n→\n∞\n\n. The zeros of the cosine function are at odd multiples of \n\nπ\n/\n2\n\n. Therefore, an approximation to the Bessel zero, \n\n\nj\nnk\n\n\n is given by
For larger values of N as would typically be used in a discretization scheme, then we can write approximately
\n
\n\n2\nWR\n≈\n\n\nN\n+\n\nn\n2\n\n\n\n\nE35
\n
This is exactly analogous to the corresponding expression for Fourier transforms. Specifically, for temporal Fourier transforms Shannon [6] argued that “If the function is limited to the time interval T and the samples are spaced 1/(2 W) seconds apart (where W is the bandwidth), there will be a total of 2WT samples in the interval. All samples outside will be substantially zero. To be more precise, we can define a function to be limited to the time interval T if, and only if, all the samples outside this interval are exactly zero. Then we can say that any function limited to the bandwidth W and the time interval T can be specified by giving \n\nN\n=\n2\nWT\n\n numbers”. Following this line of thinking, Eq. (35) states that for an nth-order Hankel transform, any function limited to the bandwidth W and the space interval R can be specified by giving \n\nN\n=\n\n\n2\nWR\n−\nn\n/\n2\n\n\n\n numbers and it will certainly be true that specifying \n\nN\n=\n2\nWR\n\n numbers will specify the function, in exact analogy to Shannon’s result.
\n
\n
\n
4.4 Proposed kernel for the discrete transform
\n
The preceding sections show that both forward and inverse discrete versions of the transforms contain an expression of the form
This leads to a natural choice of kernel for the discrete transform, as shall be outlined in the next section. To aid in in the choice of kernel for the discrete transform, we present a useful discrete orthogonality relationship shown in [11] that for \n\n1\n≤\nm\n,\ni\n≤\nN\n−\n1\n\n
where \n\n\nj\nnm\n\n\n represents the mth zero of the nth-order Bessel function \n\n\nJ\nn\n\n\nx\n\n\n, and \n\n\nδ\nmi\n\n\n is the Kronecker delta function, defined as
If written in matrix notation, then the Kronecker delta of Eq. (38) is the identity matrix.
\n
Fisk-Johnson discusses the analytical derivation of Eq. (37) in the appendix of [11]. Eq. (37) is exactly true in the limit as \n\nN\n→\n∞\n\n and is true for \n\nN\n>\n30\n\n within the limits of computational error \n\n\n\n±\n\n10\n\n−\n7\n\n\n\n\n\n. For smaller values of \n\nN\n\n, Eq. (37) holds with the worst case for the smallest value of N giving \n\n±\n\n10\n\n−\n3\n\n\n\n.
\n
\n
\n
\n
5. Transformation matrices
\n
\n
5.1 Transformation matrix
\n
With inspiration from the notation in [11], and an additional scaling factor of \n\n1\n/\n\nj\nnN\n\n\n, we define an \n\n\n\nN\n−\n1\n\n\n×\n\n\nN\n−\n1\n\n\n\n transformation matrix with the (m,k)th entry given by
In Eq. (39), the superscripts n and N refer to the order of the Bessel function and the dimension of the space that are being considered, respectively. The subscripts m and k refer to the (m,k)th entry of the transformation matrix.
\n
Furthermore, the orthogonality relationship, Eq. (37), states that
Eq. (40) states that the rows and columns of the matrix \n\n\nY\n\nm\n,\nk\n\nnN\n\n\n are orthonormal and can be written in matrix form as
\n
\n\n\nY\nnN\n\n\nY\nnN\n\n=\nΙ\n,\n\nE41
\n
where \n\nI\n\n is the \n\nN\n−\n1\n\n dimensional identity matrix and we have written the \n\nN\n−\n1\n\n square matrix \n\n\nY\n\nm\n,\nk\n\nnN\n\n\n as \n\n\nY\nnN\n\n\n. The forward and inverse truncated and discretized transforms given in Eqs. (26) and (29) can be expressed in terms of \n\n\nY\nnN\n\n\n. The forward transform, Eq. (26), can be written as
Following the notation in [12], we can also define a different \n\n\n\nN\n−\n1\n\n\n×\n\n\nN\n−\n1\n\n\n\n transformation matrix with the (m,k)th entry given by
In Eq. (44), the superscripts n and N refer to the order of the Bessel function and the dimension of the space that are being considered, respectively. The subscripts m and k refer to the (m,k)th entry of the matrix. From (39), it can be seen that \n\n\nT\n\nm\n,\nk\n\nnN\n\n=\n\nT\n\nk\n,\nm\n\nnN\n\n\n so that \n\n\nT\nnN\n\n\n is a real, symmetric matrix. The relationship between the \n\n\nT\n\nm\n,\nk\n\nnN\n\n\n and \n\n\nY\n\nm\n,\nk\n\nnN\n\n\n matrices is given by
Eq. (40) states that the rows and columns of the matrix \n\n\nT\nnN\n\n\n are orthonormal so that \n\n\nT\nnN\n\n\n is an orthogonal matrix. Furthermore, \n\n\nT\nnN\n\n\n is also symmetric. Eq. (46) can be written in matrix form as
From the previous section is it clear that the two natural choices of kernel for a DHT are either \n\n\nY\n\nm\n,\nk\n\nnN\n\n\n or \n\n\nT\n\nm\n,\nk\n\nnN\n\n\n. \n\n\nY\n\nm\n,\nk\n\nnN\n\n\n is closer to the discretized version of the continuous Hankel transform that we hope the discrete version emulates. However, \n\n\nT\n\nm\n,\nk\n\nnN\n\n\n is an orthogonal and symmetric matrix, therefore it is energy preserving and will be shown to lead to a Parseval-type relationship if chosen as the kernel for the DHT. Thus, to define a discrete Hankel transform (DHT), we can use either formulation:
Here, the transform is of any\n\nN\n−\n1\n\n dimensional vector \n\n\nf\nk\n\n\n to any\n\nN\n−\n1\n\n dimensional vector \n\n\nF\nm\n\n\n for the integers \n\nm\n,\nk\n\n where \n\n1\n≤\nm\n,\nk\n<\nN\n−\n1\n\n. This can be written in matrix form as
We note that the forward and inverse transforms are the same.
\n
Proof
\n
We show the proof for the \n\n\nY\nnN\n\n\n formulation, but it proceeds similarly if \n\n\nY\nnN\n\n\n is replaced with \n\n\nT\nnN\n\n\n. Substituting Eq. (52) into the right hand side of (50) gives
The inside summations as indicated in Eq. (55) are recognized as yielding the Dirac-delta function, the orthogonality property of Eq. (40) (or Eq. (46) if using \n\n\nT\nnN\n\n\n), which in turn yields the desired result. This proves that the DHT given by (50) can be inverted by (52).
\n
\n
\n
7. Generalized Parseval theorem
\n
Inner products are preserved and thus energies are preserved under the \n\n\nT\nnN\n\n\n matrix formulation. To see this, consider any two vectors given by the transform \n\ng\n=\n\nT\nnN\n\nG\n\n, \n\nh\n=\n\nT\nnN\n\nH\n\n then
However, under the \n\n\nY\nnN\n\n\n formulation, the inner product between \n\n\n\ng\nk\n\n\n\nJ\n\nn\n+\n1\n\n\n\n\nj\nnk\n\n\n\n\n\n and \n\n\n\nh\nk\n\n\n\nJ\n\nn\n+\n1\n\n\n\n\nj\nnk\n\n\n\n\n\n is preserved. To see this, we calculate the inner product between them as
In other words, under a DHT using the \n\n\nY\nnN\n\n\n matrix, inner products of the scaled functions are preserved but not the inner products of the functions themselves.
\n
As a consequence of the orthogonality property of \n\n\nT\nnN\n\n\n, the \n\n\nT\nnN\n\n\n based DHT is energy preserving, meaning that
In keeping with the development of the well-known discrete Fourier transform, we develop the standard toolkit of rules for the discrete Hankel transform. In the following, \n\n\nY\nnN\n\n\n is used but all expressions apply equally if \n\n\nY\nnN\n\n\n is replaced with \n\n\nT\nnN\n\n\n.
\n
\n
8.1 Transform of Kronecker-Delta function
\n
The discrete counterpart of the Dirac-delta function is the Kronecker-delta function, \n\n\nδ\n\nkk\n0\n\n\n\n. We recall that the DHT as defined above is a matrix transform from a \n\nN\n−\n1\n\n dimensional vector to another. The vector \n\n\nδ\n\nkk\no\n\n\n\n is interpreted as the vector as having zero entries everywhere except at position \n\nk\n=\n\nk\n0\n\n\n (\n\n\nk\n0\n\n\n fixed so \n\n\nδ\n\nkk\n0\n\n\n\n is a vector), or in other words, the k0th column of the \n\nN\n−\n1\n\n sized identity matrix. The DHT of the Kronecker-delta can be found from the definition of the forward transform via
The symbol \n\nH\n\n⋅\n\n\n is used to denote the operation of taking the discrete Hankel transform. This gives us our first DHT transform pair of order n dimension \n\nN\n−\n1\n\n, and we denote this relationship as
Here, \n\n\nf\nk\n\n⇔\n\nF\nm\n\n\n denotes a transform pair and \n\n\nY\n\nm\n,\n\nk\n0\n\n\nnN\n\n\n is k0th column of the matrix \n\n\nY\nnN\n\n\n.
\n
\n
\n
8.2 Inverse transform of the Kronecker Delta function
\n
From Eq. (65), we can deduce the vector \n\n\nf\nk\n\n\n that transforms to the Kronecker-delta vector \n\n\nδ\n\nmm\no\n\n\n\n function. Namely, we take the forward transform of
As before, \n\n\nY\n\nk\n,\n\nm\n0\n\n\nnN\n\n\n represents the m0th column of the transformation matrix \n\n\nY\nnN\n\n\n. From the forward definition of the transform, Eq. (50), the transform of \n\n\nY\n\nk\n,\n\nm\n0\n\n\n\nn\n,\nN\n\n\n\n is given by
In Eq. (69), \n\n\nf\n̂\n\n\nω\n\n\n is the Fourier transform of \n\nf\n\nx\n\n\n, \n\n\nF\n\n−\n1\n\n\n\n denotes an inverse Fourier transform and \n\n\ne\n\n−\niaω\n\n\n\n is the kernel of the Fourier transform operator. Motivated by this result, we define a generalized-shift operator by finding the inverse DHT of the DHT of the function multiplied by the DHT kernel. This is a discretized version of the definition of a generalized shift operator as proposed by Levitan [8] (he suggested the complex conjugate of the Fourier operator, which for Fourier transforms is the inverse transform operator). We thus propose the definition of the generalized-shifted function to be given by
\n
\n\n\nf\n\nk\n,\n\nk\no\n\n\nshift\n\n=\n\n∑\n\np\n=\n1\n\n\nN\n−\n1\n\n\n\nY\n\nk\n,\np\n\nnN\n\n\n\n\n\n\nY\n\np\n,\n\nk\no\n\n\nnN\n\n\nF\np\n\n\n\n︸\n\n\n\n\n\nshift in Hankel\n\n\n\n\ndomain\n\n\n\n\n\n,\n\nE70
\n
where \n\n1\n≤\nk\n,\n\nk\no\n\n≤\nN\n−\n1\n\n . For a single, fixed value of \n\n\nk\no\n\n\n, then \n\n\nf\n\nk\n,\n\nk\no\n\n\nshift\n\n\n is another \n\nN\n−\n1\n\n vector, with the notation \n\n\nf\n\nk\n,\n\nk\no\n\n\nshift\n\n\n implying a \n\n\nk\n0\n\n\n-shifted version of \n\n\nf\nk\n\n\n. This generalizes the notion of the shift, usually denoted \n\n\nf\n\nk\n−\n\nk\no\n\n\n\n\n, which inevitably encounters difficulty when the subscript \n\nk\n−\n\nk\no\n\n\n falls outside of the range \n\n\n1\n\nN\n−\n1\n\n\n\n. We note that if all possible shifts \n\n\nk\no\n\n\n are considered, then \n\n\nf\n\nk\n,\n\nk\no\n\n\nshift\n\n\n is a \n\nN\n−\n1\n\n square matrix (in other words, a two dimensional structure), whereas the original un-shifted \n\n\nf\nk\n\n\n is an \n\nN\n−\n1\n\n vector. For the discrete Fourier transform, when the shifted subscript \n\nk\n−\n\nk\no\n\n\n falls outside the range of the indices, is it usually interpreted modulo the size of the DFT. However, the kernel of the Fourier transform is periodic so this does not create difficulties for the DFT. The Bessel functions are not periodic so the same trick cannot be used with the Hankel transform. In fact, this lack of periodicity and lack of simple relationship between \n\n\nJ\nn\n\n\n\nx\n−\ny\n\n\n\n and \n\n\nJ\nn\n\n\nx\n\n\n is the reason that the continuous Hankel transform does not have a convolution-multiplication rule [13]. Thus, the notation \n\n\nf\n\nk\n−\n\nk\no\n\n\n\n\n would not make mathematical sense when used with the DHT. With the definition given by Eq. (70), no such confusion arises since the definition is unambiguous for all allowable values of \n\nk\n\n and \n\n\nk\no\n\n\n.
\n
The shifted function \n\n\nf\n\nk\n,\n\nk\no\n\n\nshift\n\n\n can also be expressed in terms of the original un-shifted function \n\n\nf\nk\n\n\n . Using the definition of \n\n\nF\nm\n\n\n from Eq. (50) and a dummy change of variable, then Eq. (70) becomes
As indicated in Eq. (72), the quantity in brackets can be considered to be a type of shift operator acting on the original unshifted function. We can define this as
This triple-product shift operator is similar to previous definitions of shift operators for multidimensional Fourier transforms that rely on Hankel transforms [1, 2] and of generalized Hankel convolutions [14, 15, 16].
\n
\n
\n
8.4 Transform of the generalized shift operator
\n
We now consider the forward DHT transform of the shifted function \n\n\nf\n\nk\n,\n\nk\no\n\n\nshift\n\n\n. From the definition, the DHT of the shifted function can be found from
This yields another transform pair and is the shift-modulation rule. This rule analogous to the shift-modulation rule for regular Fourier transforms whereby a shift in the spatial domain is equivalent to modulation in the frequency domain:
Note that Eq. (77) does not imply a summation over the m index. For a fixed value of \n\n\nk\no\n\n\n on the left hand side, the corresponding transformed value of \n\n\nF\nm\n\n\n is multiplied by the \n\n\nm\n\nk\no\n\n\n\nth entry of the \n\n\nY\nnN\n\n\n matrix.
\n
\n
\n
8.5 Modulation
\n
We consider the forward DHT of a function “modulated” in the space domain \n\n\nf\nk\n\n=\n\nY\n\nk\n,\n\nk\no\n\n\nnN\n\n\ng\nk\n\n\n. Here, the interpretation of \n\n\nf\nk\n\n=\n\nY\n\nk\n,\n\nk\no\n\n\nnN\n\n\ng\nk\n\n\n is that the kth entry of the vector g is multiplied by the \n\n\nk\n\nk\no\n\n\n\nth entry of \n\n\nY\nnN\n\n\n for a fixed value of \n\n\nk\no\n\n\n. No summation is implied so this is not a dot product; both \n\n\nf\nk\n\n\n and \n\n\nY\n\nk\n,\n\nk\no\n\n\nnN\n\n\ng\nk\n\n\n are \n\nN\n−\n1\n\n vectors. Again, we implement the definition of the forward transform
By comparing Eq. (81) with Eqs. (72) and (73), we recognize the shift operator as indicated in (81). This produces a modulation-shift rule as would be expected so that the forward DHT of a modulated function is equivalent to a generalized shift in the frequency domain. This yields another transform pair:
In other words, Eq. (82) says that modulation in the space domain is equivalent to shift in the frequency domain, as would be expected for a (generalized) Fourier transform.
\n
\n
\n
8.6 Convolution
\n
We consider the convolution using the generalized shifted function previously defined. The convolution of two functions is defined as
The meaning of Eq. (83) follows from the traditional definition of a convolution: multiply one of the functions by a shifted version of a second function and then sum over all possible shifts.
\n
Subsequently, from the definition of the inverse transforms, we obtain
The right hand side of Eq. (85) is clearly the inverse transform of the product of the transforms \n\n\nH\np\n\n\nF\np\n\n\n. This gives us another transform pair
9. Using the DHT to approximate the continuous transform
\n
\n
9.1 Approximation to the continuous transform
\n
Eqs. (26) and (29) show how the DHT can be used to calculate the continuous Hankel transform at finite points. From Eqs. (26) and (29), it is clear that given a continuous function \n\nf\n\nr\n\n\n evaluated at the discrete points \n\n\nr\nnk\n\n\n (given by Eq. (31)) in the space domain (\n\n1\n≤\nk\n≤\nN\n−\n1\n\n), its nth-order Hankel-transform function \n\nF\n\nρ\n\n\n evaluated at the discrete points \n\n\nρ\nnm\n\n\n (given in Eq. (31)) in the frequency domain (\n\n1\n≤\nm\n≤\nN\n−\n1\n\n), can be approximately given by
where \n\nα\n\n is a scaling factor to be discussed below, and \n\nF\n\nm\n\n=\nF\n\n\nρ\nnm\n\n\n\n, \n\nf\n\nk\n\n=\nf\n\n\nr\nnk\n\n\n\n.
\n
Similarly, given a continuous function \n\nF\n\nρ\n\n\n evaluated at the discrete points \n\n\nρ\nnm\n\n\n in the frequency domain (\n\n1\n≤\nm\n≤\nN\n−\n1\n\n), its nth-order inverse Hankel transform \n\nf\n\nr\n\n\n evaluated at the discrete points \n\n\nr\nnk\n\n\n (\n\n1\n≤\nk\n≤\nN\n−\n1\n\n), can be approximately given by
For both the forward and inverse transforms, \n\nα\n\n is a scaling factor and \n\nα\n=\n\n\nR\n2\n\n\nj\nnN\n\n\n\n or equivalently \n\nα\n=\n\n\nj\nnN\n\n\nW\nρ\n2\n\n\n\n, where R is the effective space limit and \n\n\nW\nρ\n\n\n is the effective band limit (in m−1). The scaling factor \n\nα\n\n chosen for using the DHT to approximate the CHT depends on whether information is known about the band-limit or space-limit. We already introduced the idea of an effective limit in the previous sections, where a function was defined as being “effectively limited in space by R” means that if \n\nr\n>\nR\n\n, then \n\nf\n\nr\n\n≈\n0\n\n for all \n\nr\n>\nR\n\n. In other words, the function can be made as close to zero as desired by selecting an R that is large enough. The same idea can be applied to the spatial frequency domain, where the effective domain is denoted by \n\n\nW\nρ\n\n\n.
\n
The relationship \n\n\nW\nρ\n\nR\n=\n\nj\nnN\n\n\n, derived in the previous sections, holds between the ranges in space and frequency. Choosing \n\nN\n\n determines the dimension (size) of the DHT and determines \n\n\nj\nnN\n\n\n. The determination of \n\n\nj\nnN\n\n\n (via choosing N) determines the range in one domain once the range in the other domain is chosen. In fact, any two of \n\nR\n,\n\nW\nρ\n\n,\n\nj\nnN\n\n\n can be chosen but the third must follow from \n\n\nW\nρ\n\nR\n=\n\nj\nnN\n\n\n. A similar relationship applies when using the discrete Fourier transform, any two of the range in each domain and the size of the DFT can be chosen independently. In previous sections, we showed that the size of the DHT required can be quickly approximated from \n\n2\nWR\n=\n\n\n\nW\nρ\n\nR\n\nπ\n\n≈\n\n\nN\n+\n\nn\n2\n\n\n\n\n.
\n
\n
\n
9.2 Sampling points
\n
In order to properly use the discrete transform to approximate the continuous transform, a function has to be sampled at specific discretization points. For a finite spatial range \n\n\n0\nR\n\n\n and a Hankel transform of order \n\nn\n\n, these sampling points are given in the space domain as \n\n\nr\nnk\n\n\n and frequency domain by \n\n\nρ\nnm\n\n\n, given in Eq. (31) and repeated here for convenience
It is important to note that as in the case of the computation of the transformation matrix \n\n\nY\nnN\n\n\n, the first Bessel zero \n\n\nj\n\nn\n1\n\n\n\n used in computing the discretization points is the first non-zero value. Eq. (95) demonstrates that some of the ideas known for the DFT also apply to the DHT. That is, making the spatial domain larger (larger R) implies making the sampling density tighter in frequency (the \n\n\nρ\nnm\n\n\n get closer together). Similarly, making the frequency domain larger (larger \n\n\nW\nρ\n\n\n) implies a tighter sampling density (smaller step size) in the spatial domain. Although \n\n\nj\nnm\n\n\n are not equispaced, they are nearly so for higher values of m and for purposes of developing quick intuitions on ideas such as sampling density, if is convenient to approximately think of \n\n\nj\nnk\n\n≈\n\n\nk\n+\n\nn\n2\n\n\n\nπ\n\n.
\n
\n
\n
9.3 Implementation and availability of the software
\n
The software used to calculate the DHT is based on the MATLAB programming language. The software can be downloaded from
The implementation of the discrete Hankel transform is decomposed into distinct functions. These functions consist of various steps that have to be performed in order to properly execute the transform. These steps are as follows:
Calculate \n\nN\n\n Bessel zeros of the Bessel function of order \n\nn\n\n
Generate of \n\nN\n\n sample points (if using the DHT to approximate the continuous transform)
Sample the function (if needed)
Create the \n\n\nY\nnN\n\n\n transformation matrix
Perform the matrix-function multiplication
\n
The steps are the same regardless if the function is in the space or frequency domain. Furthermore, the \n\n\nY\nnN\n\n\n transformation matrix is used for both the forward and inverse transform. The second and third steps in the list above are only needed if the function (vector) to be transformed is not already given as a set of discrete points. In the case of a continuous function, it is important to evaluate the function at the sampling points in Eq. (95). Failing to do so results in the function not being properly transformed since there is a necessary relationship between the sampling points and the transformation matrix \n\n\nY\nnN\n\n\n. In order to perform the steps listed above, several Matlab functions have been developed. These functions are shown in Table 1.
\n
\n
\n
\n
\n\n
\n
Function name
\n
Calling sequence
\n
Description
\n
\n\n\n
\n
besselzero
\n
besselzero(n,k,kind)
\n
Calculation of k Bessel zeros of the nth-order Bessel function of kind—developed in [17]
\n
\n
\n
freqSampler
\n
freqSampler(R,zeros)
\n
Creation of sample points in the frequency domain (Eq. (95))
\n
\n
\n
spaceSampler
\n
spaceSampler(R,zeros)
\n
Creation of sample points in the space domain (Eq. (95))
\n
\n
\n
YmatrixAssembly
\n
YmatrixAssembly(n,N,zeros)
\n
Creation of \n\n\nY\nnN\n\n\n matrix from the zeros
\n
\n\n
Table 1.
Set of available functions.
\n
Additionally, the matlab script GuidetoDHT.m is included to illustrate the execution of the necessary computational steps.
\n
\n
\n
9.4 Verification of the software
\n
The software was tested by using the DHT to approximate the computation of both the continuous Hankel forward and inverse transforms and comparing the results with known (continuous) forward and inverse Hankel transform pairs. Different transform orders \n\nn\n\n were evaluated.
\n
For the purpose of testing the accuracy of the DHT and IDHT, the dynamic error was used, defined as [12]
This error function compares the difference between the exact function values \n\nf\n\nv\n\n\n (evaluated from the continuous function) and the function values estimated via the discrete transform, \n\n\nf\n∗\n\n\nν\n\n\n, scaled with the maximum value of the discretely estimated samples. The dynamic error uses the ratio of the absolute error to the maximum amplitude of the function on a log scale. Therefore, negative decibel errors imply an accurate discrete estimation of the true transform value. The transform was also tested for accuracy on itself by performing consecutive forward and then inverse transformation. This is done to verify that the transforms themselves do not add errors. For this evaluation, the average absolute error \n\n\n1\nN\n\n\n∑\n\ni\n=\n1\n\nN\n\n\n\n\nf\ni\n\n−\n\n\nf\ni\n\n∗\n\n\n\n\n was used. The methodology of the testing is given in further detail in [18] and also in the theory paper [3].
\n
\n
\n
\n
10. Summary and conclusions
\n
In this chapter, the theory of the discrete Hankel transform as a “standalone” transform was motivated and presented. The standard operating rules for multiplication, modulation, shift and convolution were also demonstrated. Sampling and interpolation theorems were shown. The theory and numerical steps to use the presented discrete theory for the purpose of approximating the continuous Hankel transform was also shown. Links to the publicly available, open-source numerical code were also included.
\n
\n
Acknowledgments
\n
The author acknowledges the contributions of Mr. Ugo Chouinard, who developed and tested the numerical code to which links are provided in this chapter. This work was financially supported by the Natural Sciences and Engineering Research Council of Canada.
\n
Conflict of interest
The author declares that there are no conflicting interests.
\n',keywords:"Fourier-Bessel, Hankel transform, transform rules, discrete transform, polar coordinates",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/65719.pdf",chapterXML:"https://mts.intechopen.com/source/xml/65719.xml",downloadPdfUrl:"/chapter/pdf-download/65719",previewPdfUrl:"/chapter/pdf-preview/65719",totalDownloads:1176,totalViews:0,totalCrossrefCites:1,totalDimensionsCites:1,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:36,impactScoreQuartile:2,hasAltmetrics:0,dateSubmitted:"November 7th 2018",dateReviewed:"January 14th 2019",datePrePublished:"February 18th 2019",datePublished:"December 4th 2019",dateFinished:"February 18th 2019",readingETA:"0",abstract:"The Hankel transform is an integral transform and is also known as the Fourier-Bessel transform. Until recently, there was no established discrete version of the transform that observed the same sort of relationship to its continuous counterpart as the discrete Fourier transform does to the continuous Fourier transform. Previous definitions of a discrete Hankel transform (DHT) only focused on methods to approximate the integrals of the continuous Hankel integral transform. Recently published work has remedied this and this chapter presents this theory. Specifically, this chapter presents a theory of a DHT that is shown to arise from a discretization scheme based on the theory of Fourier-Bessel expansions. The standard set of shift, modulation, multiplication, and convolution rules are shown. In addition to being a discrete transform in its own right, this DHT can approximate the continuous forward and inverse Hankel transform.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/65719",risUrl:"/chapter/ris/65719",book:{id:"7614",slug:"fourier-transforms-century-of-digitalization-and-increasing-expectations"},signatures:"Natalie Baddour",authors:[{id:"62384",title:"Dr.",name:"Natalie",middleName:null,surname:"Baddour",fullName:"Natalie Baddour",slug:"natalie-baddour",email:"nbaddour@uottawa.ca",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Ottawa",institutionURL:null,country:{name:"Canada"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Hankel transforms and Bessel series",level:"1"},{id:"sec_2_2",title:"2.1 Hankel transform",level:"2"},{id:"sec_3_2",title:"2.2 Fourier Bessel series",level:"2"},{id:"sec_5",title:"3. Sampling and interpolation theorems for band-limited and space-limited functions",level:"1"},{id:"sec_5_2",title:"3.1 Sampling theorem for a band-limited function",level:"2"},{id:"sec_6_2",title:"3.2 Interpolation theorem for a band-limited function",level:"2"},{id:"sec_7_2",title:"3.3 Interpretation in terms of a jinc",level:"2"},{id:"sec_8_2",title:"3.4 Sampling theorem for a space-limited function",level:"2"},{id:"sec_9_2",title:"3.5 Interpolation theorem for a space-limited function",level:"2"},{id:"sec_11",title:"4. Intuitive discretization scheme for the Hankel transform",level:"1"},{id:"sec_11_2",title:"4.1 Forward transform",level:"2"},{id:"sec_12_2",title:"4.2 Inverse transform",level:"2"},{id:"sec_13_2",title:"4.3 Intuitive discretization scheme and kernel",level:"2"},{id:"sec_14_2",title:"4.4 Proposed kernel for the discrete transform",level:"2"},{id:"sec_16",title:"5. Transformation matrices",level:"1"},{id:"sec_16_2",title:"5.1 Transformation matrix",level:"2"},{id:"sec_17_2",title:"5.2 Another choice of transformation matrix",level:"2"},{id:"sec_19",title:"6. Discrete forward and inverse Hankel transform",level:"1"},{id:"sec_20",title:"7. Generalized Parseval theorem",level:"1"},{id:"sec_21",title:"8. Transform rules",level:"1"},{id:"sec_21_2",title:"8.1 Transform of Kronecker-Delta function",level:"2"},{id:"sec_22_2",title:"8.2 Inverse transform of the Kronecker Delta function",level:"2"},{id:"sec_23_2",title:"8.3 The generalized shift operator",level:"2"},{id:"sec_24_2",title:"8.4 Transform of the generalized shift operator",level:"2"},{id:"sec_25_2",title:"8.5 Modulation",level:"2"},{id:"sec_26_2",title:"8.6 Convolution",level:"2"},{id:"sec_27_2",title:"8.7 Multiplication",level:"2"},{id:"sec_29",title:"9. Using the DHT to approximate the continuous transform",level:"1"},{id:"sec_29_2",title:"9.1 Approximation to the continuous transform",level:"2"},{id:"sec_30_2",title:"9.2 Sampling points",level:"2"},{id:"sec_31_2",title:"9.3 Implementation and availability of the software",level:"2"},{id:"sec_32_2",title:"9.4 Verification of the software",level:"2"},{id:"sec_34",title:"10. Summary and conclusions",level:"1"},{id:"sec_35",title:"Acknowledgments",level:"1"},{id:"sec_38",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Baddour N. Operational and convolution properties of two-dimensional Fourier transforms in polar coordinates. Journal of the Optical Society of America. A. 2009;26(8):1767-1777\n'},{id:"B2",body:'Baddour N. Operational and convolution properties of three-dimensional Fourier transforms in spherical polar coordinates. Journal of the Optical Society of America. A. 2010;27(10):2144-2155\n'},{id:"B3",body:'Baddour N, Chouinard U. Theory and operational rules for the discrete Hankel transform. JOSA A. 2015;32(4):611-622\n'},{id:"B4",body:'Piessens R. The Hankel transform. In: The Transforms and Applications Handbook. Vol. 2. Boca Raton: CRC Press; 2000. pp. 9.1-9.30\n'},{id:"B5",body:'Schroeder J. Signal processing via Fourier-Bessel series expansion. Digital Signal Processing. 1993;3(2):112-124\n'},{id:"B6",body:'Shannon CE. Communication in the presence of noise. Proceedings of the IEEE. 1998;86(2):447-457\n'},{id:"B7",body:'Watson GN. A Treatise on the Theory of Bessel Functions. Cambridge, UK: Cambridge University Press; 1995\n'},{id:"B8",body:'Levitan BM. Generalized displacement operators. In: Encyclopedia of Mathematics. Heidelberg: Springer. p. 2002\n'},{id:"B9",body:'Shannon CE. Communication in the presence of noise. Proceedings of the IRE. 1949;37(1):10-21\n'},{id:"B10",body:'Arfken GB. Mathematical Methods for Physicists. 6th ed. Boston: Elsevier; 2005\n'},{id:"B11",body:'Johnson HF. An improved method for computing a discrete Hankel transform. Computer Physics Communications. 1987;43(2):181-202\n'},{id:"B12",body:'Guizar-Sicairos M, Gutiérrez-Vega JC. Computation of quasi-discrete Hankel transforms of integer order for propagating optical wave fields. Journal of the Optical Society of America. A. 2004;21(1):53-58\n'},{id:"B13",body:'Baddour N. Application of the generalized shift operator to the Hankel transform. Springerplus. 2014;3(1):246\n'},{id:"B14",body:'Belhadj M, Betancor JJ. Hankel convolution operators on entire functions and distributions. Journal of Mathematical Analysis and Applications. 2002;276(1):40-63\n'},{id:"B15",body:'de Sousa Pinto J. A generalised Hankel convolution. SIAM Journal on Mathematical Analysis. 1985;16(6):1335-1346\n'},{id:"B16",body:'Malgonde SP, Gaikawad GS. On a generalized Hankel type convolution of generalized functions. Proceedings of the Indian Academy of Sciences–Mathematical Sciences. 2001;111(4):471-487\n'},{id:"B17",body:'G. von Winckel, “Bessel Function Zeros—File Exchange—MATLAB Central.” [Online]. Available from: http://www.mathworks.com/matlabcentral/fileexchange/6794-bessel-function-zeros. [Accessed: 06-Jun-2015]\n'},{id:"B18",body:'Chouinard U. Numerical simulations for the discrete Hankel transform [B.A.Sc. thesis]. Ottawa, Canada: University of Ottawa; 2015\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Natalie Baddour",address:"nbaddour@uottawa.ca",affiliation:'
Department of Mechanical Engineering, University of Ottawa, Ottawa, Ontario, Canada
Toxocariosis is a neglected zoonotic disease transmitted from dogs and cats to humans. This is mainly caused by the presence and action of the nematode Toxocara canis (T. canis) and less frequently by Toxocara cati (T. cati syn. T. mystax). T. canis uses canines, mainly puppies, as its definitive host, and T. cati uses kittens. In addition, they use a wide variety of paratenic hosts, including pigs, sheep, rabbits, rats, mice, other mammals, chickens, and other birds. In humans, the infection is accidental, and the parasite behaves similarly as it does in paratenic hosts. Some invertebrates, such as earthworms and cockroaches, can also have Toxocara larvae in their tissues or their gut [1, 2].
Adult T. canis worms live in the small intestine of puppies. The females measure from 10 to 18 cm, and the males measured from 4 to 10 cm. At the anterior end, they have three small lips that do not protrude beyond the diameter of the body. A dentigerous border can be seen on the inner surface of each lip. Behind the lips are a pair of cervical fins that give the anterior end of the worm an arrowhead appearance. The posterior end in males ends coiled toward the ventral part and has a terminal narrowing in the form of an appendix, and a pair of small and symmetrical spicules (0.75–0.95 mm) are observed. In females, the vulva is located approximately in the middle of the body, and the posterior end ends at a straight, blunt point. T. cati adults are very similar to T. canis; the cervical fins are broader and convex, giving the anterior end a more marked arrowheaded appearance; males are 3–6 cm long, and females are 4–10 cm long [3].
2. Biological cycle
Embryonated T. canis eggs are shed in the feces of puppies. In the environment, a first-stage larva develops inside the egg, which molts twice until it becomes larva 3 (L3). Larvated eggs (passive L3 inside) are the infective stage. Depending on humidity and temperature, the development of the infective stage requires 2–5 weeks in the environment. In susceptible hosts after ingestion of the infective stage, L3 hatches (active L3) in the duodenum and traverses the intestinal wall; the larvae pass into the lymphatic flow or blood capillaries. From this moment on, the development and migration of the larvae vary depending on whether the host is a young dog (<3 months), an adult dog, a pregnant bitch, or a paratenic host (rats, mice, birds, and humans, among others) [4].
In puppies, L3 migrate via blood or lymph to the liver, where they remain for 1 to 2 days. Subsequently, they migrate through blood, pass through the lumen of the atrium and right ventricle of the heart and via the pulmonary artery, reach the lungs, and cross the capillaries to reach the alveoli. The larvae migrate through the lumen of the bronchioles, bronchi, trachea, larynx, and pharynx (tracheal migration), where they are swallowed; during this tracheal migration, the larvae molt to L4. The larvae remain in the stomach for some time (up to Day 10 postinfection), return to the duodenum, and molt to L5 or preadult to finally become adults (19–27 days post-infection). The prepatent period is 4–5 weeks [4].
In paratenic hosts and adult dogs, L3 larvae migrate through the blood and are distributed throughout the body, mainly to the striated muscle, liver, lungs, kidneys, and brain, where they remain for years in a state of latency or dormancy as infective somatic larvae (dormant larvae) until they die and calcify.
In pregnant bitches, on approximately Day 20 of gestation, many of their dormant larvae are reactivated by the influence of progesterone. Between Days 43 and 47 of gestation, under the influence of progesterone and prolactin, the larvae cross the placenta and infect the fetuses. The larvae remain in the fetal liver until birth; later, by blood, they migrate to the lungs where they remain during the first week of life, molting to L4 occurs during this stage or later when the larva arrives in the stomach by tracheal migration. By the end of the third week, the larvae molt at L5 and develop rapidly into adult worms. After copulation, the females produce eggs that are passed in the feces of the pups at 15 days of age. In recently delivered bitches, some reactivated larvae arrive by the influence of prolactin on the mammary gland and are excreted in the colostrum and milk to be ingested by the puppies, constituting another important source of infection for the litter. The larvae ingested in this way molt at L4 and L5 in the intestinal lumen, where they develop into adult worms without tracheal migration [5].
In recently delivered bitches, some larvae may reactivate during gestation migrate to the intestine, molt to L4 and L5 and become adult worms. Bitches can remain up to 60 days passing eggs in feces until the adult worms are eliminated spontaneously. This is one of the ways adult worms can develop in adult dogs [1].
Dormant larvae in the tissues of paratenic hosts can be reactivated when they are predated. If the predator is another paratenic host, the ingested reactivated larvae undergo a new somatic migration and become dormant in this new host. On the other hand, if the predator is an adult dog, the ingested reactivated larvae molt at L4 and L5 and develop into adult worms in the lumen of the small intestine without further somatic migration. In this way, dogs can spend a short time excreting eggs in the feces until the adult worms are eliminated spontaneously. This is another way that adult worms can develop in adult dogs [1].
The life cycle of T. cati is similar to that of T. canis except that prenatal transplacental infection in this parasite does not occur [6].
3. Epidemiology
3.1 Dogs and cats
T. canis is the most common nematode in dogs in many regions of the world and T. cati in cats. In a meta-analysis study where data from more than 13 million dogs from 60 countries were included, the overall prevalence of Toxocara infection in dogs was found to be 11.1%. The prevalence was estimated in different World Health Organization regions: Eastern Mediterranean (19.2%), Africa (18.5%), South-East Asia (11.9%), North America (11.1%), South America (10.9%), Europe (10.8%) and Western Pacific (6.4%) [7].
In a second meta-analysis where data from 2,158,069 cats from 51 countries were included, an overall prevalence of T. cati of 17% was found. The prevalence was estimated in different World regions: African (43.3%), Eastern Mediterranean (21.6%), North America (18.3%), Europe (17.8%), Western Pacific (17.3%), South-East Asia (14.9%),and South American (12.6%)[8].
Transplacental transmission from bitches to their puppies is the most important form of T. canis infection in dogs. Not all somatic larvae in bitches are reactivated during the same gestation; thus, reactivation of larvae occurs in subsequent gestations. In addition, bitches become reinfected by ingesting persistent larvated eggs in an environment contaminated with fecal matter from their puppies. Transplacental transmission does not appear to occur in cats with T. cati, making lactogenic infection the most common form of infection in kittens [4, 6].
Puppies are the main source of environmental contamination; they can excrete eggs in feces from 15 days of birth, and the greatest egg shedding occurs between 1 and 3 months of age, when they can eliminate more than a million eggs per day. Gradually, the worm burden in the intestine tends to decrease, and they stop shedding eggs before reaching 6 months of age. In addition, the larvae ingested by the lactogenic route gradually increase the worm burden and the elimination of eggs in the puppies. Puppies under three months of age are the only hosts that can develop adult worms in the intestine by ingesting larvated eggs, although apparently, this is not their main route of infection [9].
Adult Toxocara females are very prolific, producing between 25,000 and 85,000 eggs per day, and the presence of many females in the intestine of a puppy can mean the elimination of enormous numbers of eggs in the feces (>100,000/g). In the environment, when eggs are protected from direct sunlight and desiccation, they develop to the infective stage (L3 passive) 2–4 weeks after shedding. In earthen soils, the eggs can remain viable for many months, accumulating in the environment. Therefore, the soil in areas where dogs with toxocariosis commonly defecate is considered a permanent source of infection for animals and humans. In addition, rainwater can carry the eggs to distant places and accumulate them in large concentrations in some places [1]. A study that included 42,797 soil samples in 40 countries showed a global prevalence of Toxocara eggs in public places of 21%. The estimated prevalence rates in the different regions ranged from Western Pacific (35%), Africa (27%), South America (25%), South-East Asia (21%), the Middle East and North Africa (18%), Europe (18%) and the North and Central Americas (13%) [10].
Paratenic hosts infected by ingesting larvated eggs present in soil, food or water accumulate L3 in their tissues. If these are predated, they can be a source of infection for adult dogs. If predated by another paratenic host, the larvae can infect the new host, bypassing a definitive host.
3.2 Humans
Due to the great difficulty of identifying the physical presence of somatic larvae, the most common way to identify Toxocara infection in humans is by serological tests (ELISA and Western blot). Serologically, it is not possible to distinguish between a T. canis infection and a T. cati infection, and although T. canis infection has generally been considered to be the predominant infection in humans, the seroprevalence of T. cati has not been determined, which could have been underestimated [11].
The seroprevalence of Toxocara in humans varies in different regions of the world. A meta-analysis carried out in 2019 that included 265,327 participants in 71 countries showed an estimated global Toxocara seroprevalence rate of 19.0%. The pooled seroprevalence for regions was as follows: African (37.7%), South-East Asia (34.1%), Western Pacific (24.2%), American regions (22.8%), European regions (10.5%), and Eastern Mediterranean region (8.2%) [12]. Seroprevalence has been associated with different risk factors, such as age, contact with young dogs and kittens, socioeconomic level, consumption of vegetables, and unboiled water, ethnicity, educational level, living in a rural area and pet ownership [13, 14]. The serological differences associated with the different ethnic groups in some countries may be the result of different contextual exposures linked, among other factors, to their socioeconomic level, segregation, and the environmental conditions in which the different ethnic groups live, and not necessarily due to a genetic predisposition [15].
The most common way of infection in humans occurs through the accidental ingestion of Toxocara larvated eggs, which can be found on soil in public parks, gardens, dirt floors, sandboxes, and vegetables irrigated with sewage, among others. Although people of any age can be infected, children are more frequently affected due to their habits of playing with pets and dirt, geophagia, and pica, in addition to their commonly poor hygiene habits [16, 17, 18]. Infection can also occur through the ingestion of somatic larvae present in raw or undercooked meat and viscera of cattle, pigs, and poultry, among others, which act as paratenic hosts (Figure 1) [19, 20, 21, 22]. Blattella germanica and Periplaneta americana cockroaches have recently been shown to be able to ingest and shed larvated T. canis eggs in their feces, suggesting that they could carry infective eggs from dog feces to kitchens where human food is prepared [2].
Figure 1.
Epidemiology of toxocariosis from the one health approach. The biological cycle of Toxocara sp. involves definitive (dogs and cats), paratenic (several species of mammals and birds), and incidental (human) hosts. Puppies are the main eliminators of immature eggs into the environment (1). In optimal environmental conditions of humidity and temperature, passive larvae 3 develop inside the eggs, which are the main infective stage for all hosts (2). Paratenic or incidental hosts that ingest larvated eggs maintain somatic larvae in their tissues (3) that are infective to predators of the infected paratenic host. Human infection occurs mainly by ingestion of larvated eggs or by ingestion of raw animal meat or viscera (chicken, pig, beef) with infective somatic larvae (4). The ingestion of larvated eggs can be facilitated by the consumption of contaminated vegetables (5). Somatic larvae present in the definitive host are transmitted to puppies by transplacental (dog) and lactogenic (dog and cat) routes (6). Blue arrows show the dynamics of egg development in the environment, red arrows show transmission from larvated eggs, and yellow arrows show transmission from somatic larvae.
There are multiple reports of the presence of Toxocara eggs in the hair of dogs and cats, which is why it has been proposed that they are a source of infection for their owners [23, 24, 25, 26]. However, the presence of larvated infective eggs in the hair is very low, probably due to poor temperature and humidity conditions [27], suggesting a low risk of infection for humans when petting the hair of their pets, although the possibility exists.
4. Canine and feline toxocariosis
4.1 Pathogenesis and clinical picture
The adult worms of T. canis and T. cati feed on intestinal content, compete with the host for nutrients and, depending on the worm burden, can produce different degrees of malnutrition. The presence of adult worms causes intestinal irritation, which induces decreased absorption of nutrients and is responsible for diarrhea and vomiting observed in some young animals. The presence of adult worms in the intestinal lumen exerts a mechanical obstructive action on the normal flow of intestinal content. Microscopically, the presence of adult worms produces mucosal muscular hypertrophy, intestinal villus atrophy, and crypt hyperplasia [1].
Larval migration in mild or moderate infections in puppies generally does not produce obvious clinical signs; however, larval migration in severe infections produces respiratory signs such as tachypnea, cough, and runny nose. Nervous signs such as incoordination or convulsions are occasionally observed in puppies due to the passage of the larvae through the brain. In puppies with intense prenatal infection, the lesions produced by the passage of the larvae in the liver, lungs, or central nervous system can cause the death of the puppies in the first 2 weeks of life [28].
Mild to moderate adult worm infections in puppies are usually asymptomatic or cause mild digestive symptoms and growth retardation. In severe infections, dirty-looking bristly hair, rough skin, painful intestinal distention, vomiting (frequently with adult worms), bulging abdomen (mainly when they have just eaten), presence of large amounts of gas produced by intestinal dysbiosis, alternating periods of constipation and diarrhea with profuse mucus, decreased appetite and growth retardation, can be observed. The blood count shows eosinophilia and anemia. Occasionally, there may be the death of puppies due to aspiration of vomit and intestinal obstruction or rupture. The presence of large numbers of adult worms as a result of massive prenatal infections in puppies can cause complete obstruction of the intestinal lumen, intussusception of the small intestine, and death of the entire litter [9, 29, 30].
In kittens, there is no transplacental transmission; therefore, the development of adult worms occurs until almost 30 days of age and the beginning of the elimination of eggs at approximately 50 days of age. The clinical picture is similar to that described in dogs but less severe, diarrhea, vomiting, and loss of appetite predominate, and deaths are very rare. The highest incidence of T. cati in cats occurs between 2 and 6 months of age; in general, the worm burden is lower in kittens than in puppies and occurs when the kittens are older and therefore have a higher degree of development [9, 31].
4.2 Diagnosis of toxocariosis in dogs and cats
Sporadically, shed adult worms can be observed macroscopically in the vomit or feces of puppies. The detection of Toxocara eggs in feces is performed by coproparasitoscopic techniques, such as Faust or McMaster; however, this can only be done when there are adult stages in the intestine, mainly in puppies [3]. In the eggs, three external layers are observed, forming the shell; the outermost layer is albuminous, the middle layer is lipoid, and the inner layer chitinous. The shell has depressions on the surface, called pits, which give it an appearance similar to a golf ball. The egg measures 75–85 μm and has a protoplasmic mass that occupies the entire interior.
In adult dogs and paratenic hosts, infection by somatic larvae can be demonstrated by the detection of specific antibodies against excretion-secretion antigens using immunological techniques such as ELISA or Western blot; however, due to their cost, difficulty in obtaining the antigens, and their difficult implementation, these techniques are not widely used in the veterinary field [32].
5. Human toxocariosis
Human toxocariosis is a neglected worldwide zoonosis caused by nematodes of the genus Toxocara (T. canis and T. cati). Current data indicate that toxocariosis is an infection of global distribution whose importance has been significantly underestimated [12, 15, 33, 34]. Human toxocariosis occurs in four clinical forms: visceral larvae migrans (VLM) syndrome, ocular larvae migrans (OLM) syndrome, neurotoxocariosis and covert toxocariosis.
5.1 VLM syndrome
In the 1950s, second-stage larvae of T. canis (now known to be third-stage larvae) were identified in the tissues of several children associated with the presence of clinical signs and a pathology that has since been known as VLM [35]. The associated syndrome in these children was characterized by extensive eosinophilia, hepatomegaly, splenomegaly, hypergammaglobulinemia, and chronic cough with eosinophilic pulmonary infiltration. VLM is more common in children (1–5 years) than in adults because they are more exposed to the infection through the ingestion of larvated eggs of T. canis, favored by factors such as living with puppies, poor hygienic habits, and pica [14, 36].
In humans, after ingestion of infective eggs, the larvae hatch in the small intestine and penetrate the intestinal wall, from which they are transported by the blood circulation to various organs, mainly the liver, heart, lungs, brain, muscle, and eyes [37]. In these organs, the larvae actively migrate, aided by proteases with which they cause tissue damage and exert a histophagous spoliating action (traumatic action). The migrating larvae do not continue their development; however, they remain dormant for several years, but they continue to secrete excretion-secretion antigens that induce an inflammatory response in some organs, such as the liver and spleen (hepatosplenomegaly), or are mediators of immunopathological alterations in other organs, such as the lung, where they produce eosinophilic pulmonary infiltration related to cough and persistent secretion [38].
Given the impossibility of carrying out studies in humans, experimental models have been developed in different species of paratenic hosts, such as primates [39], rabbits [40], rats [41], mice [42], and gerbils [43], where the sequence of pathophysiological and immunological events of VML have been studied. In these models, it has been observed that organ injuries can be acute or chronic. The acute phase is characterized by a severe inflammatory response that causes multifocal lesions with necrosis and vacuolization with polymorphonuclear infiltrate, mainly neutrophils with the presence of eosinophils in the liver and lungs. The chronic phase is characterized by the presence of granulomatous lesions with infiltrates of mononuclear cells, fibroblasts, and eosinophils, as well as the presence of fibrosis around the lesion with traces of calcification in the center of the lesions, which in some cases can be extensive. The main organs affected are the liver, lung, kidney, and brain (Figure 2). These lesions can be seen with or without the presence of the larva, which suggests the importance of the antigenic excretion-secretion products released by the larva in the tissues.
Figure 2.
Lesions produced by Toxocara canis larvae in Mongolian gerbils (Meriones unguiculatus). A: lung with chronic granuloma. B: kidney with chronic granuloma with a larva trapped inside (L). C: larva in the pigmented layer of the retina with rupture of blood capillaries. D: larva the in brain with no apparent tissue reaction (photo credits: Dr. Alba-Hurtado).
The clinical picture of VLM includes hyperleukocytosis (30,000–60,000 cells/mm3), eosinophilia (14–90%), abdominal pain, enlargement of lymph nodes, hepatomegaly, splenomegaly, increased ishemagglutinins and liver enzymes, intermittent fever, cough, and bronchospasm, among others [44, 45, 46, 47]. The severity of the condition depends on the number of eggs ingested and the presence of larvae in critical places; although most patients recover and the signs subside with anthelmintic treatment, deaths from this infection have been reported [48, 49].
The diagnosis of VLM is based on the initial detection of antibodies against excretion-secretion antigens of T. canis by ELISA and its confirmation by Western blot in patients with eosinophilia, with high concentrations of serum IgE or with suggestive clinical manifestations. [50, 51, 52]. It has been proposed that the confirmatory diagnosis can be validated with the identification of a larva from a biopsy or by some molecular tests, such as PCR, DNA hybridization and restriction fragment length polymorphism, or sequencing of Toxocara ribosomal DNA; however, it is still in the of experimentation in animal models and is not available for humans [53]. Different tools, such as ultrasound (US), contrast-enhanced ultrasound (CEUS), contrast-enhanced computed tomography (ceCT), contrast-enhanced magnetic resonance imaging (ceMRI) and positron emission tomography (PET), are currently used to obtain suggestive images of the main lesions in different human organs [49, 54].
5.2 OLM syndrome
This syndrome was first described by Wilder in 1950, who found nematode larvae (unidentified at the time) in 24 of 46 pseudogliomas in eyes enucleated for endophthalmitis with apparent retinoblastoma [55]. Nichols later identified the larvae as T. canis in sections from four out of five of the eyes examined by Wilder [56]. Although, it is currently accepted that T. canis larvae are the main etiologic agent of OLM, it has also been shown that T. cati can cause ocular infections in humans [57, 58, 59].
OLM is a disease that generally occurs in young patients. In a systematic review and meta-analysis of studies published internationally, it was observed that the highest infection rate was detected in the 1–25 mean age group; within this range, the highest prevalence occurred between 11 and 20 years of age and was higher in men than in women [34]. It has been shown that having contact with dogs, ownership of dogs or cats, exposure to soil, and consuming raw/undercooked meat can be risk factors for OLM [12, 26, 34, 60].
OLM is generally observed in the absence of clinical signs and symptoms of VLM; it is considered to occur in people initially exposed to a small number of larvae, so they do not mount a significant immune response (many patients with a clinical diagnosis of OLM are seronegative to Toxocara), and the larvae migrate freely through various organs and accidentally reach the eye [61, 62]. Observations in experimental models and some clinical evidence indicate that Toxocara larvae infect the eye by migrating through capillaries or directly from the brain through the optic nerve [63, 64, 65, 66].
The lesions detected in the eyes of patients diagnosed with OLM have been granulomas located near the optic disc or intraretinal (see Figure 2C), posterior and peripheral retinochoroiditis, panuveitis, optic papillitis, uveitis, retinal deformation or detachment, idiopathic epiretinal membranes, infiltration of inflammatory cells in the humor vitreous, hemorrhagic lesions and neuroretinitis as a sequel to migration of larvae in the retina [60, 67, 68, 69]. The main clinical manifestations include poor visual acuity, vision loss, strabismus, leukorrhea, eye irritation, and endophthalmitis [58, 70]. In most cases, lesions occur in only one eye, although there are reports of bilateral conditions [70].
The initial diagnosis of OLM is based on clinical signs and observation of lesions with an ophthalmoscope in the fundus examination. Confirmation of the diagnosis can be made by the detection of antibodies against excretion-secretion antigens of T. canis by ELISA in the vitreous humor of the affected eye and the study of the lesions by ultrasound biomicroscopy (UBM) and optical coherence tomography (OCT) [71, 72].
5.3 Neurotoxocariosis
The first report of the presence of an encapsulated larva of T. canis in the brain of a child was in 1951; originally, the larva was identified as probably Ascaris lumbricus [73]; later, this larva was identified as T. canis [74]. The damage produced by Toxocara larvae in the central nervous system (CNS) of humans has been widely discussed by many authors. The pathology depends on the number of larvae, the location of the larvae in the nervous system, the time postinfection, the immune response, and some intrinsic factors of the host. Most cases of neuro toxocariosis have been attributed to the presence of T. canis and, less frequently, to T. cati; however, the latter cannot be ruled out in some neurological infections. In experimental models, a greater tendency for T. canis to migrate to the CNS than T. cati has been observed [75].
In humans, many Toxocara infections in the CNS can go unnoticed and do not produce manifestations; therefore, their frequency is unknown. Some autopsy studies have shown the presence of larvae in the leptomeninges, gray and white matter of the cerebrum, cerebellum, thalamus, and spinal cord, unrelated to previous neurological signs [76].
In experimental models, it has been shown that T. canis larvae in the CNS can produce areas of necrosis, loss of Purkinje cells, glial nerve fibers and nerve sheaths, granulomatous lesions, emorrhagic and exudative lesions, vasculitis with eosinophilic and lymphocytic infiltration, gliosis and hemosiderosis. Some larvae can be observed without any response around them (see Figure 2D) [76, 77].
The clinical pictures of neurotoxocariosis in humans rarely occur simultaneously with signs of VLM. Most clinical manifestations occur in adult men with an average age of 35–42 years. Clinical signs associated with neurotoxocariosis may be indicators of different neurological disorders, such as myelitis (sensation disorders such as tingling sensation or hypoesthesia to specific dermatomes; motor disorders such as sphincter disturbances and conus medullaris syndrome; autonomic disturbances such as bladder and bowel dysfunction, and erectile failure), encephalitis (focal deficits, confused state, seizure and cognitive disorders) or meningitis (headaches, stiff neck/neck pain, nausea or vomiting, and Kernig’s/Brudzinski’s sign). Fever may occur on some occasions, although this is not a constant sign [76, 78].
The association between T. Canis seropositivity and cognitive development is controversial and has been widely discussed by several authors. Some authors, such as Magnaval et al. [79], found no association between seropositivity and any recognizable neurological syndrome; however, other authors have shown an association between seropositivity and lower cognitive development in children; however, due to incomplete controls and low sample size, the results are not clear [80, 81, 82, 83].
In this context, Walsh and Haseeb [84], conducted one of the most conclusive studies; they analyzed a sample of 3,949 children representative of the US child population. Seropositive to T. canis children scored significantly lower on the Scale for Children-Revised (WISC-R) and Wide Range Achievement Test-Revised (WRAT-R) than seronegative children. Moreover, this relationship was independent of socioeconomic status, ethnicity, sex, rural residence, cytomegalovirus infection and blood lead levels. These results show another facet of the importance of toxocariosis as a neglected infection.
The diagnosis of neurotoxocariosis is difficult because there is no characteristic clinical syndrome. Due to the lack of confirmatory diagnostic tests and the nonspecific nature of its symptoms, neurotoxocariosis is probably underdiagnosed. As there is no universally accepted criterion for the diagnosis of this syndrome, a comprehensive diagnosis must be considered that must include the broad spectrum of neurological manifestations (signs of meningitis, encephalitis, myelitis, and/or cerebral vasculitis), together with high titers of antibodies against Toxocara in cerebrospinal fluid and/or blood, eosinophilia in blood and/or cerebrospinal fluid, suggestive radiological images, the presence of risk factors and clinical and radiological improvement after anthelmintic therapy [54, 78, 85].
5.4 Covert toxocariosis
Taylor et al. [86] proposed the term covert toxocariosis to describe a new clinical entity of human toxocariosis. It is currently considered that covert toxocariosis is characterized by nonspecific symptoms and signs that are not associated with the VLM, OLM,or neurotoxocariosis. Clinical manifestations include asthma, acute bronchitis, pneumonia, wheezing with or without Loeffler’s syndrome, chronic urticaria or eczema, lymphadenopathy, myositis, and pseudorheumatoid syndrome, with or without eosinophilia.
The excretion-secretion antigens produced by T. canis during migration are strong stimulants of Th2-associated immune responses and the consequent induction of IL-4, IL-5, IL10, and IL-13. This cytokine profile induces an increase in the level of specific IgE-antibodies and eosinophilia, which are effectors to kill some larvae. These same effectors contribute to airway hypersensitivity and inflammation, associating chronic T. canis infection with allergic disorders such as asthma, allergic rhinitis, atopic dermatitis, and urticaria [87, 88, 89].
Asthma is a lung disease characterized by an exacerbation of the immune response in the airways to a variety of external stimuli, which produces inflammation, bronchospasm, and obstruction of the airways, which are reversible spontaneously or with treatment. Since years ago, several epidemiological and experimental studies have shown a significant relationship between Toxocara infection and the development of asthma, mainly in children [90, 91, 92]. Meta-analysis studies, where extensive collections of published data were made, have confirmed this association. Li et al. [93] using data from 723 asthmatic patients and 807 controls found a significantly higher prevalence of T. canis infection in patients with asthma than in controls (OR 3.36, P < .001). Aghaei et al. [87] using data from 872 asthmatics and 4597 non-asthmatics children, found an increased risk for asthma in children with Toxocara infection seropositivity (OR, 1.91; 95% CI, 1.47–2.47).
The exact mechanisms by which Toxocara infection induces asthma and other allergic disorders remain unclear. Toxocara larval migration has been associated with an intense immune response, which causes strong allergic inflammation involving the intestine, muscle, liver, kidney, and lung [43, 94]. An animal model study (mice) showed that previous infection with T. canis intensified the ovalbumin-induced allergic airway inflammatory response associated with elevated eosinophil counts and IgE antibody levels in bronchoalveolar fluid and increased expression of IL-4 mRNA in the lung [92]. Several authors have described skin manifestations associated with toxocariosis and the risk of seropositive patients presenting skin lesions [95]. Significant associations have been observed between Toxocara seropositivity and pruritus (OR = 4.1, P < 0.1) and chronic urticaria (OR = 6.9, P < 0.0001) [96, 97]. Some of these patients presented with symptoms of VLM or OLM; however, the majority had no signs of previous Toxocara infection. Similar to neurotoxocariosis, there is no specific diagnosis for the clinical symptoms of cutaneous toxocariosis, so the participation of T. canis as a producer of skin alterations has probably been underestimated.
6. Comprehensive control of toxocariosis
The main role in the control of toxocariosis falls on the veterinarian, who is responsible for the diagnosis and deworming programs in dogs and cats, as well as the awareness and health education of pet owners so that they are aware of the threat of this and other infectious diseases from pets to humans. Periodic deworming of dogs and cats is an effective strategy to reduce the worm burden and, therefore, the number of eggs in the environment [98]. Puppies and kittens must be dewormed (piperazine, ivermectin, mebendazole, pyrantel, and febantel, among others) at one month of age, and the treatment should be repeated at least twice in 15 days. In adult dogs, coproparasitoscopic examinations (Faust technique) should be carried out every 6 months, and positive dogs should be dewormed, with special care for dogs with known predatory habits. There are no effective antiparasitic agents against somatic larvae of Toxocara sp. In adult female dogs and cats, therefore, to reduce transplacental and/or lactogenic transmission to their puppies, it is necessary to reduce the number of infective eggs in the environment where they live.
The main way of infection in humans is the ingestion of infective eggs (L3 passive) that contaminate their environment. The fecal of dogs and, to a lesser extent, of cats in the soil of public parks, gardens, ridges, and rural areas, among others, is the cause of the gradual accumulation of infective eggs of Toxocara sp. in these places. Due to its high resistance, there are no chemical products capable of inactivating these eggs in the soil without seriously affecting other organisms and damaging the ecosystem. Therefore, one of the most important strategies for the control of environmental contamination is the immediate collection of dog feces eliminated during walks and its subsequent disposal in the drainage. It should always be considered that puppies and kittens are the main egg eliminators; however, adult dogs can also eventually eliminate eggs [99].
One of the risk factors most frequently associated with human toxocariosis is ownership of dogs or cats. For this reason, it is necessary to wash the floors daily with soap and water inside the houses or patios where the dogs live and defecate to detach the infective eggs from the surfaces and achieve their mechanical dragging to the drainage, considering that the infective eggs resist most commercial disinfectants. In addition, due to the possible presence of infective eggs attached to pet hair, it is necessary to periodically bathe and brush dogs and cats to avoid the presence of Toxocara eggs or other parasites in the hair.
Drainage water contaminated with Toxocara eggs can reach places where vegetables are grown or there may be dogs that defecate in these places, so vigorous washing of vegetables with drinking water is essential, especially those that are eaten raw and are grown at ground level (lettuce, cabbage, carrots, and strawberries, among many others) to reduce the risk of ingestion of infective eggs by humans. Another source of infection in humans is the ingestion of raw or undercooked meat or viscera of paratenic hosts infected with somatic larvae (chickens, pigs, cattle, and ducks, among others) in traditional dishes, so it is suggested that this type of dish is cooked with meat from animals raised in conditions free of the parasite. Cooking meat kills somatic larvae. At the government level, it is necessary to implement educational campaigns for the management of pet feces, knowledge of this and other zoonotic diseases, and the control of feral dogs and cats.
7. Health professionals involved
In summary, toxocariosis is a complex disease that, for its comprehensive control from a one health perspective, requires the knowledge of researchers and different health professionals. The veterinarian is the professional responsible for the diagnosis, control, and prevention of toxocariosis in pets that act as definitive hosts of the parasite (dogs and cats), as well as in domestic species that can act as paratenic hosts (chickens, pigs, beef, rabbits, etc.).
From the perspective of human health, the joint work of a very wide variety of health professionals is required to achieve an early and accurate diagnosis of the disease or at least a firm suspicion of the condition. Among these are parasitologists, infectologists, pediatricians, allergists, ophthalmologists, neurologists, dermatologists, imaging specialists, and epidemiologists, who are sensitized and trained to cover the entire clinical spectrum that human toxocariosis can produce. In addition, highly trained laboratory personnel are required for the parasitological, immunological, and molecular diagnosis of toxocariosis in animals and humans.
Acknowledgments
This chapter was funded by grants from PAPIIT/UNAM (No. IN210322 and IN211222). We deeply thank César Cuenca-Verde from FESC-UNAM for their technical assistance.
Conflict of interest
The authors declare no conflict of interest.
\n',keywords:"Toxocara, one health, toxocariosis, zoonosis, visceral larva migrans, ocular larva migrans",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/81194.pdf",chapterXML:"https://mts.intechopen.com/source/xml/81194.xml",downloadPdfUrl:"/chapter/pdf-download/81194",previewPdfUrl:"/chapter/pdf-preview/81194",totalDownloads:22,totalViews:0,totalCrossrefCites:0,dateSubmitted:"March 1st 2022",dateReviewed:"March 15th 2022",datePrePublished:"April 22nd 2022",datePublished:null,dateFinished:"April 10th 2022",readingETA:"0",abstract:"Toxocariosis is a neglected zoonotic infection caused by the nematodes Toxocara canis or Toxocara cati. The distribution of the disease is worldwide and mainly affects dogs and cats, and its larval stage can cause human infection with serious repercussions on the health of its hosts. The infection causes a delay in the development, digestive disorders, nonspecific nervous manifestations, and occasionally death of some puppies and kittens associated with hyperparasitosis. In humans, the infection produces clinical syndromes known as visceral larva migrans (VLM), ocular larva migrans (OLM), neurotoxocariosis and covert toxocariosis. The close contact of people with their pets and the environmental conditions that favor the transmission of this diseased place it within the context of one health. The One Health concept is defined as the collaborative efforts of multiple disciplines (medical personnel, veterinarians, researchers, etc.) that work locally, nationally, and globally to achieve optimal health for people, animals, and the environment, from this perspective, toxocariosis is a study model in which classic and recent knowledge of the medical and veterinary area must be combined for its full understanding, with a goal of establishing integrative criteria for its treatment, control, and prevention.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/81194",risUrl:"/chapter/ris/81194",signatures:"Fernando Alba-Hurtado and Marco Antonio Muñoz-Guzmán",book:{id:"11380",type:"book",title:"Parasitic Helminths and Zoonoses - From Basic to Applied Research",subtitle:null,fullTitle:"Parasitic Helminths and Zoonoses - From Basic to Applied Research",slug:null,publishedDate:null,bookSignature:"Prof. Jorge Morales-Montor, Dr. Víctor Hugo Del Río-Araiza and Dr. Romel Hernández Bello",coverURL:"https://cdn.intechopen.com/books/images_new/11380.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-80355-568-3",printIsbn:"978-1-80355-567-6",pdfIsbn:"978-1-80355-569-0",isAvailableForWebshopOrdering:!0,editors:[{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Biological cycle",level:"1"},{id:"sec_3",title:"3. Epidemiology",level:"1"},{id:"sec_3_2",title:"3.1 Dogs and cats",level:"2"},{id:"sec_4_2",title:"3.2 Humans",level:"2"},{id:"sec_6",title:"4. Canine and feline toxocariosis",level:"1"},{id:"sec_6_2",title:"4.1 Pathogenesis and clinical picture",level:"2"},{id:"sec_7_2",title:"4.2 Diagnosis of toxocariosis in dogs and cats",level:"2"},{id:"sec_9",title:"5. Human toxocariosis",level:"1"},{id:"sec_9_2",title:"5.1 VLM syndrome",level:"2"},{id:"sec_10_2",title:"5.2 OLM syndrome",level:"2"},{id:"sec_11_2",title:"5.3 Neurotoxocariosis",level:"2"},{id:"sec_12_2",title:"5.4 Covert toxocariosis",level:"2"},{id:"sec_14",title:"6. Comprehensive control of toxocariosis",level:"1"},{id:"sec_15",title:"7. Health professionals involved",level:"1"},{id:"sec_16",title:"Acknowledgments",level:"1"},{id:"sec_19",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Deplazes P, Eckert J, Mathis A, Samson-Himmelstjerna GV, Zahner H. Parasitology in Veterinary Medicine. Wageningen Academic Publishers: Wageningen; 2016. p. 652'},{id:"B2",body:'González-García T, Muñoz-Guzmán MA, Sánchez-Arroyo H, Prado-Ochoa MG, Cuéllar-Ordaz JA, Alba-Hurtado F. Experimental transmission of Toxocara canis from Blattella germanica and Periplaneta americana cockroaches to a paratenic host. Veterinary Parasitology. 2017;246:5-10'},{id:"B3",body:'Alba-Hurtado F. Parasitología Veterinaria. Ciudad de México: UNAM; 2020. p. 184'},{id:"B4",body:'Schnieder T, Laabs EM, Welz C. Larval development of Toxocara canis in dogs. Veterinary Parasitology. 2011;175:193-206'},{id:"B5",body:'Muñoz-Guzmán MA, Alba-Hurtado F. Progesterone and prolactin: Hormones important for the reactivation of Toxocara canis larvae in bitches. Advances in Neuroimmune Biology. 2018;7:67-78'},{id:"B6",body:'Coati N, Schnieder T, Epe C. Vertical transmission of Toxocara cati Schrank 1788 (Anisakidae) in the cat. Parasitology Research. 2004;92:142-146'},{id:"B7",body:'Rostami A, Riahi SM, Hofmann A, Ma G, Wang T, Behniafar H, et al. Global prevalence of Toxocara infection in dogs. Advances in Parasitology. 2020;109:561-583'},{id:"B8",body:'Rostami A, Sepidarkish M, Ma G, Wang T, Ebrahimi M, Fakhri Y, et al. Global prevalence of Toxocara infection in cats. Advances in Parasitology. 2020;109:615-639'},{id:"B9",body:'Overgaauw PA, Nederland V. Aspects of Toxocara epidemiology: Toxocarosis in dogs and cats. Critical Reviews in Microbiology. 1997;23:233-251'},{id:"B10",body:'Fakhri Y, Gasser RB, Rostami A, Fan CK, Ghasemi SM, Javanian M, et al. Toxocara eggs in public places worldwide-A systematic review and meta-analysis. Environmental Pollution. 2018;242:1467-1475'},{id:"B11",body:'Fisher M. Toxocara cati: An underestimated zoonotic agent. Trends in Parasitology. 2003;19:167-170'},{id:"B12",body:'Rostami A, Riahi SM, Holland CV, Taghipour A, Khalili-Fomeshi M, Fakhri Y, et al. Seroprevalence estimates for toxocariasis in people worldwide: A systematic review and metaanalysis. PLoS Neglected Tropical Diseases. 2019;13:e0007809'},{id:"B13",body:'Gyang PV, Akinwale OP, Lee YL, Chuang TW, Orok AB, Ajibaye O, et al. Seroprevalence, disease awareness, and risk factors for Toxocara canis infection among primary schoolchildren in Makoko, an urban slum community in Nigeria. Acta Tropica. 2015;46:135-140'},{id:"B14",body:'Holland CV. Knowledge gaps in the epidemiology of Toxocara: The enigma remains. Parasitology. 2017;144:81-94'},{id:"B15",body:'Hotez PJ, Wilkins PP. Toxocariasis: America’s most common neglected infection of poverty and a helminthiasis of global importance? PLoS Neglected Tropical Diseases. 2009;3:e400'},{id:"B16",body:'Manini MP, Marchioro AA, Colli CM, Nishi L, Falavigna-Guilherme AL. Association between contamination of public squares and seropositivity for Toxocara spp. in children. Veterinary Parasitology. 2012;188:48-52'},{id:"B17",body:'Hernández SA, Gabrie JA, Rodríguez CA, Matamoros G, Rueda MM, Canales M, et al. An integrated study of Toxocara infection in Honduran children: Human seroepidemiology and environmental contamination in a coastal community. Tropical Medicine and Infectious Disease. 2020;5:135'},{id:"B18",body:'Wang S, Li H, Yao Z, Li P, Wang D, Zhang H, et al. Toxocara infection: Seroprevalence and associated risk factors among primary school children in central China. Parasite. 2020;27:30. DOI: 10.1051/parasite/2020028'},{id:"B19",body:'Hoffmeister B, Glaeser S, Flick H, Pornschlegel S, Suttorp N, Bergmann F. Cerebral toxocariasis after consumption of raw duck liver. The American Journal of Tropical Medicine and Hygiene. 2007;76:600-602. DOI: 10.1.1.318.4997&rep=rep1&type=pdf'},{id:"B20",body:'Yoshikawa M, Nishiofuku M, Moriya K, Ouji Y, Ishizaka S, Kasahara K, et al. A familial case of visceral toxocariasis due to consumption of raw bovine liver. Parasitology International. 2008;57:525-529'},{id:"B21",body:'Choi D, Lim JH, Choi DC, Lee KS, Paik SW, Kim SH, et al. Transmission of Toxocara canis via ingestion of raw cow liver: A cross-sectional study in healthy adults. The Korean Journal of Parasitology. 2012;50:23-27. DOI: 10.3347/kjp.2012.50.1.23'},{id:"B22",body:'Karaca I, Menteş J, Nalçacı S. Toxocara neuroretinitis associated with raw meat consumption. Turkish Journal of Ophthalmology. 2018;48:258. DOI: 10.4274/tjo.27085'},{id:"B23",body:'Roddie G, Holland C, Stafford P, Wolfe A. Contamination of fox hair with eggs of Toxocara canis. Journal of Helminthology. 2008;82:293-296'},{id:"B24",body:'da Cunha-Amaral HL, Rassier GL, Pepe MS, Gallina T, Villela MM, de Oliveira-Nobre M, et al. Presence of Toxocara canis eggs on the hair of dogs: A risk factor for visceral larva migrans. Veterinary Parasitology. 2010;174:115-118'},{id:"B25",body:'Bakhshani A, Maleki M, Haghparast A, Shirvan SP, Borji H. A survey on Toxocara cati eggs on the hair of stray cats: A potential risk factor for human toxocariasis in Northeastern Iran. Comparative Immunology, Microbiology and Infectious Diseases. 2019;64:10-13'},{id:"B26",body:'Maurelli MP, Santaniello A, Fioretti A, Cringoli G, Rinaldi L, Menna LF. The presence of Toxocara eggs on dog’s fur as potential zoonotic risk in animal-assisted interventions: A systematic review. Animals. 2019;9:827. DOI: 10.3390/ani9100827'},{id:"B27",body:'Keegan JD, Holland CV. A comparison of Toxocara canis embryonation under controlled conditions in soil and hair. Journal of Helminthology. 2013;87:78-84'},{id:"B28",body:'Miller AD. Pathology of larvae and adults in dogs and cats. Advances in Parasitology. 2020;109:537-544'},{id:"B29",body:'Parsons JC. Ascarid infections of cats and dogs. The Veterinary Clinics of North America: Small Animal Practice. 1987;17:1307-1339'},{id:"B30",body:'Epe C. Intestinal nematodes: Biology and control. Veterinary Clinics of North America: Small Animal Practice. 2009;39:1091-1107. DOI: 10.1016/j.cvsm.2009.07.002'},{id:"B31",body:'Ursache AL, Györke A, Mircean V, Dumitrache MO, Codea AR, Cozma V. Toxocara cati and other parasitic enteropathogens: More commonly found in owned cats with gastrointestinal signs than in clinically healthy ones. Pathogens. 2021;10:198'},{id:"B32",body:'Muñoz-Guzmán MA, Alba-Hurtado F. Secretory-excretory antigens of Toxocara canis recognized by puppies of the Mexico City metropolitan area. Vet Méx. 2010;41:59-64'},{id:"B33",body:'Ma G, Holland CV, Wang T, Hofmann A, Fan CK, Maizels RM, et al. Human toxocariasis. The Lancet Infectious Diseases. 2018;18:14-24'},{id:"B34",body:'Badri M, Eslahi AV, Olfatifar M, Dalvand S, Houshmand E, Abdoli A, et al. Keys to unlock the enigma of ocular toxocariasis: A systematic review and meta-analysis. Ocular Immunology and Inflammation. 2021;29:1-12'},{id:"B35",body:'Beaver PC, Snyder CH, Carrera GM, Dent JH, Lafferty JW. Chronic eosinophilia due to visceral larva migrans: Report of three cases. Pediatrics. 1952;9:7-19'},{id:"B36",body:'Carvalho EA, Rocha RL. Toxocariasis: Visceral larva migrans in children. The Journal of Pediatrics. 2012;87:100-110'},{id:"B37",body:'Lim JH. Toxocariasis of the liver: Visceral larva migrans. Abdominal Imaging. 2008;33:151-156'},{id:"B38",body:'Morsy TA. Toxocariasis: Visceral and ocular larva migrans. Journal of the Egyptian Society of Parasitology. 2020;50:41-48'},{id:"B39",body:'Aljeboori TI, Ivey MH. Toxocara canis infection in baboons. The American Journal of Tropical Medicine and Hygiene. 1970;19:249-254'},{id:"B40",body:'Morales OL, Lopez MC, Nicholls RS, Agudelo C. Identification of Toxocara canis antigens by Western blot in experimentally infected rabbits. Revista do Instituto de Medicina Tropical de São Paulo. 2002;44:213-216'},{id:"B41",body:'Del Río-Araiza VH, Nava-Castro KE, Alba-Hurtado F, Quintanar-Stephano A, Muñoz-Guzmán MA, Cuenca-Micò O, et al. Endocrine immune interactions during chronic toxocariasis caused by Toxocara canis in a murine model: New insights into the pathophysiology of an old infection. Veterinary Parasitology. 2018;252:173-179'},{id:"B42",body:'Kavitha KT, Sreekumar C, Latha BR, Gowri AM, Nagarajan B, Azhahianambi P, et al. Migratory behaviour and pathological changes of Toxocara canis in organs and tissues of experimentally infected Balb/c mice. J Entomol Zool St. 2018;6:2388-2392'},{id:"B43",body:'Alba-Hurtado F, Muñoz-Guzmán MA, Valdivia-Anda G, Tórtora JL, Ortega-Pierres MG. Toxocara canis: Larval migration dynamics, detection of antibody reactivity to larval excretory–secretory antigens and clinical findings during experimental infection of gerbils (Meriones unguiculatus). Experimental Parasitology. 2009;122:1-5'},{id:"B44",body:'Snyder CH. Visceral larva migrans Ten years’experience. Pediatrics. 1961;28:85-91'},{id:"B45",body:'Baldisserotto M, Conchin CF, Soares MDG, Araujo MA, Kramer B. Ultrasound findings in children with toxocariasis: Report on 18 cases. Pediatric Radiology. 1999;29:316-319. DOI: 10.1007/s002470050596.pdf'},{id:"B46",body:'Wiśniewska-Ligier M, Woźniakowska-Gęsicka T, Sobolewska-Dryjańska J, Markiewicz-Jóźwiak A, Wieczorek M. Analysis of the course and treatment of toxocariasis in children-a long-term observation. Parasitology Research. 2012;110:2363-2371. DOI: 10.1007/s00436-011-2772-y'},{id:"B47",body:'Desai SN, Pargewar SS, Agrawal N, Bihari C, Rajesh S. Hepatic visceral larva migrans with atypical manifestations: A report of three cases. Tropical Gastroenterology. 2020;39:211-221. DOI: 10.7869/tg.507'},{id:"B48",body:'Rugiero E, Cabera ME, Ducach G, Noemi I, Viovy A. Systemic toxocariasis in the adult patient. Revista Médica de Chile. 1995;40:1097-1099'},{id:"B49",body:'Kuenzli E, Neumayr A, Chaney M, Blum J. Toxocariasis-associated cardiac diseases—A systematic review of the literature. Acta Tropica. 2016;154:107-120'},{id:"B50",body:'Mohamad S, Azmi N, Noordin R. Development and evaluation of a sensitive and specific assay for diagnosis of human toxocariasis by use of three recombinant antigens (TES-26, TES-30USM, and TES-120). Journal of Clinical Microbiology. 2009;47:1712-1717. DOI: 10.1128/JCM.00001-09'},{id:"B51",body:'Fillaux J, Magnaval JF. Laboratory diagnosis of human toxocariasis. Veterinary Parasitology. 2013;193:327-336'},{id:"B52",body:'Mazur-Melewska K, Mania A, Sluzewski W, Figlerowicz M. Clinical pathology of larval toxocariasis. Advances in Parasitology. 2020;109:153-163'},{id:"B53",body:'Özbakış G, Doğanay A. Visceral larva migrans detection using PCR–RFLP in BALB/c mice infected with Toxocara canis. Journal of Helminthology. 2020;94:1-8'},{id:"B54",body:'Dietrich CF, Cretu C, Dong Y. Imaging of toxocariasis. Advances in Parasitology. 2020;109:165-187'},{id:"B55",body:'Wilder HC. Nematode endophthalmitis. Transactions of the American Academy of Ophthalmology and Otolaryngology. 1950;55:99-109'},{id:"B56",body:'Nichols RL. The etiology of visceral larva migrans: I. Diagnostic morphology of infective second-stage Toxocara larvae. Journal of Parasitology. 1956;42:349. DOI: 10.2307/3274518'},{id:"B57",body:'MRH T. Ocular toxocariasis. In: Holland CV, Smith HV, editors. Toxocara: The Enigmatic Parasite. Pondicherry: Cromwell Press Ltd; 2006. pp. 127-144'},{id:"B58",body:'Pivetti-Pezzi P. Ocular toxocariasis. International Journal of Medical Sciences. 2009;6:129-130. DOI: 10.7150/ijms.6.129'},{id:"B59",body:'Zibaei M, Sadjjadi SM, Jahadi-Hosseini SH. Toxocara cati larvae in the eye of a child: A case report. Asian Pacific Journal of Tropical Biomedicine. 2014;4:S53-S55. DOI: 10.12980/APJTB.4.2014C1281'},{id:"B60",body:'Ahn SJ, Woo SJ, Jin Y, Jin Y, Chang YS, Kim TW, et al. Clinical features and course of ocular Toxocariasis in adults. PLoS Neglected Tropical Diseases. 2014;8:e2938. DOI: 10.1371/journal.pntd.0002938'},{id:"B61",body:'Sharkey JA, McKay PS. Ocular toxocariasis in a patient with repeatedly negative ELISA titre to Toxocara canis. The British Journal of Ophthalmology. 1993;77:253-254. DOI: 10.1136/bjo.77.4.253'},{id:"B62",body:'Fata A, Hosseini SM, Woo SJ, Zibaei M, Berenji F, Farash BRH, et al. Frequency of Toxocara antibodies in patients clinically suspected to ocular toxocariasis in the northeast of Iran. Iranian Journal of Parasitology. 2020;16:305-311'},{id:"B63",body:'Alba-Hurtado F, Tortora PJL, Tsutsumi V, Ortega-Pierres MG. Histopathological investigation of experimental ocular toxocariasis in gerbils. International Journal for Parasitology. 2000;30:143-147'},{id:"B64",body:'Taylor MRH. The epidemiology of ocular toxocariasis. Journal of Helminthology. 2001;75:109-118'},{id:"B65",body:'Hayashi E, Akao N, Fujita K. Evidence for the involvement of the optic nerve as a migration route for larvae in ocular toxocariasis of Mongolian gerbils. Journal of Helminthology. 2003;77:311-315'},{id:"B66",body:'Choi KD, Choi JH, Choi SY, Jung JH. Toxocara optic neuropathy: Clinical features and ocular findings. International Journal of Ophthalmology. 2018;11:520-523'},{id:"B67",body:'Yokoi K, Goto H, Sakai JI, Usui M. Clinical features of ocular toxocariasis in Japan. Ocular Immunology and Inflammation. 2003;11:269-275'},{id:"B68",body:'Stewart JM, Cubillan LD, Cunningham JR, Emmett T. Prevalence, clinical features, and causes of vision loss among patients with ocular toxocariasis. Retina. 2005;25:1005-1013. DOI: 10.1097/00006982-200512000-00009'},{id:"B69",body:'Bae KW, Ahn SJ, Park KH, Woo SJ. Diagnostic value of the serum anti-toxocara IgG titer for ocular toxocariasis in patients with uveitis at a tertiary hospital in Korea. Korean Journal of Ophthalmology. 2016;30:258-264'},{id:"B70",body:'Shields JA. Ocular toxocariasis. A review. Survey of Ophthalmology. 1984;28:361-381'},{id:"B71",body:'Campbell JP, Wilkinson CP. Imaging in the diagnosis and management of ocular toxocariasis. International Ophthalmology Clinics. 2012;52:145-153'},{id:"B72",body:'Inchauspe S, Echandi LV, Dodds EM. Diagnosis of ocular toxocariasis by detecting antibodies in the vitreous humor. Archivos de la Sociedad Española de Oftalmología. 2018;93:220-224'},{id:"B73",body:'Beautyman W, Woolf AL. An Ascaris larva in the brain in association with acute anterior poliomyelitis. The Journal of Pathology and Bacteriology. 1951;63:635-647'},{id:"B74",body:'Beautyman W, Beaver PC, Buckley JJ, Woolf AL. Review of a case previously reported as showing an ascarid larva in the brain. The Journal of Pathology and Bacteriology. 1966;91:271-273'},{id:"B75",body:'Springer A, Heuer L, Janecek-Erfurth E, Beineke A, Strube C. Histopathological characterization of Toxocara canis-and T. cati-induced neurotoxocarosis in the mouse model. Parasitology Research. 2019;118:2591-2600'},{id:"B76",body:'Meliou M, Mavridis IN, Pyrgelis ES, Agapiou E. Toxocariasis of the nervous system. Acta Parasitologica. 2020;65:291-299'},{id:"B77",body:'Cardillo N, Rosa A, Ribicich M, López C, Sommerfelt I. Experimental infection with Toxocara cati in BALB/c mice, migratory behaviour and pathological changes. Zoonoses and Public Health. 2009;56:198-205'},{id:"B78",body:'Deshayes S, Bonhomme J, de La Blanchardière A. Neurotoxocariasis: A systematic literature review. Infection. 2016;44:565-574. DOI: 10.1007/s15010-016-0889-8'},{id:"B79",body:'Magnaval JF, Galindo V, Glickman LT, Clanet M. Human Toxocara infection of the central nervous system and neurological disorders: A case control study. Parasitology. 1997;115:537-543'},{id:"B80",body:'Worley G, Green JA, Frothingham TE, Sturner RA, Walls KW, Pakalnis VA, et al. Toxocara canis infection: Clinical and epidemiological associations with seropositivity in kindergarten children. The Journal of Infectious Diseases. 1984;149:591-597'},{id:"B81",body:'Jarosz W, Mizgajska-Wiktor H, Kirwan P, Konarski J, Rychlicki W, Wawrzyniak G. Developmental age, physical fitness and Toxocara seroprevalence amongst lower secondary students living in rural areas contaminated with Toxocara eggs. Parasitology. 2010;137:53-63'},{id:"B82",body:'Marmor M, Glickman L, Shofer F, Faich LA, Rosenberg C, Cornblatt B, et al. Toxocara canis infection of children: Epidemiologic and neuropsychologic findings. American Journal of Public Health. 1987;77:554-559. DOI: 10.2105/AJPH.77.5.554'},{id:"B83",body:'Nelson S, Greene T, Ernhart CB. Toxocara canis infection in preschool age children: Risk factors and the cognitive development of preschool children. Neurotoxicology and Teratology. 1996;18:167-174'},{id:"B84",body:'Walsh MG, Haseeb MA. Reduced cognitive function in children with toxocariosis in a nationally representative sample of the United States. International Journal for Parasitology. 2012;42:1159-1163'},{id:"B85",body:'Fan CK. Pathogenesis of cerebral toxocariasis and neurodegenerative diseases. Advances in Parasitology. 2020;109:233-259'},{id:"B86",body:'Taylor MR, Keane CT, O\'connor P, Girdwood ARW, Smith H. Clinical features of covert toxocariasis. Scandinavian Journal of Infectious Diseases. 1987;19:693-696'},{id:"B87",body:'Aghaei S, Riahi SM, Rostami A, Mohammadzadeh I, Javanian M, Tohidi E, et al. Toxocara spp. infection and risk of childhood asthma: A systematic review and meta-analysis. Acta Tropica. 2018;182:298-304'},{id:"B88",body:'Maizels RM. Toxocara canis: Molecular basis of immune recognition and evasion. Veterinary Parasitology. 2013;193:365-374'},{id:"B89",body:'Mazur-Melewska K, Figlerowicz M, Cwalińska A, Mikoś H, Jończyk-Potoczna K, Lewandowska-Stachowiak M, et al. Production of interleukins 4 and 10 in children with hepatic involvement in the course of Toxocara spp. infection. Parasite Immunology. 2016;38:101-107. DOI: 10.1111/pim.12303'},{id:"B90",body:'Hakim SL, Thadasavanth M, Shamilah RR, Yogeswari S. Prevalence of Toxocara canis antibody among children with bronchial asthma in Klang Hospital, Malaysia. Transactions of the Royal Society of Tropical Medical and Hygiene. 1997;91:528-528'},{id:"B91",body:'Muñoz-Guzmán MA, del Río-Navarro BE, Valdivia-Anda G, Alba-Hurtado F. The increase in seroprevalence to Toxocara canis in asthmatic children is related to cross-reaction with Ascaris suum antigens. Allergologia et Immunopathologia. 2010;38:115-121'},{id:"B92",body:'Pinelli E, Brandes S, Dormans J, Gremmer E, Van Loveren H. Infection with the roundworm Toxocara canis leads to exacerbation of experimental allergic airway inflammation. Clinical and Experimental Allergy. 2008;38:649-658'},{id:"B93",body:'Li L, Gao W, Yang X, Wu D, Bi H, Zhang S, et al. Asthma and toxocariasis. Annals of Allergy, Asthma & Immunology. 2014;113:187-192'},{id:"B94",body:'Cooper PJ. Toxocara canis infection: An important and neglected environmental risk factor for asthma? Clinical and Experimental Allergy. 2008;38:551-553'},{id:"B95",body:'Gavignet B, Piarroux R, Aubin F. Millon L, Humbert P. Cutaneous manifestations of human toxocariasis. Journal of the American Academy of Dermatology 2008;59:1031-1042'},{id:"B96",body:'Wolfrom E, Chene G, Boisseau H, Beylot C, Geniaux M, Taieb A. Chronic urticaria and Toxocara canis. Lancet. 1995;345:196'},{id:"B97",body:'Wolfrom E, Chene G, Lejoly-Boisseau H, Beylot C, Geniaux M, Taieb A. Chronic urticaria and toxocara canis infection. A case-control study. Annales de Dermatologie et de Venereologie. 1996, January;123(4):240-246'},{id:"B98",body:'Palmer CS, Thompson RA, Traub RJ, Rees R, Robertson ID. National study of the gastrointestinal parasites of dogs and cats in Australia. Veterinary Parasitology. 2008;151:181-190'},{id:"B99",body:'Lee AC, Schantz PM, Kazacos KR, Montgomery SP, Bowman DD. Epidemiologic and zoonotic aspects of ascarid infections in dogs and cats. Trends in Parasitology. 2010;26:155-161'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Fernando Alba-Hurtado",address:null,affiliation:'
Facultad de Estudios Superiores Cuautitlán, Department of Biological Sciences, National Autonomous University of Mexico, Cuautitlán Izcalli, Mexico
'},{corresp:"yes",contributorFullName:"Marco Antonio Muñoz-Guzmán",address:"mmunoz74@hotmail.com",affiliation:'
Facultad de Estudios Superiores Cuautitlán, Department of Biological Sciences, National Autonomous University of Mexico, Cuautitlán Izcalli, Mexico
'}],corrections:null},book:{id:"11380",type:"book",title:"Parasitic Helminths and Zoonoses - From Basic to Applied Research",subtitle:null,fullTitle:"Parasitic Helminths and Zoonoses - From Basic to Applied Research",slug:null,publishedDate:null,bookSignature:"Prof. Jorge Morales-Montor, Dr. Víctor Hugo Del Río-Araiza and Dr. Romel Hernández Bello",coverURL:"https://cdn.intechopen.com/books/images_new/11380.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-80355-568-3",printIsbn:"978-1-80355-567-6",pdfIsbn:"978-1-80355-569-0",isAvailableForWebshopOrdering:!0,editors:[{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"202681",title:"Dr.",name:"Mojca",middleName:null,surname:"Duh",email:"mojca.duh@um.si",fullName:"Mojca Duh",slug:"mojca-duh",position:null,biography:"Mojca Duh is a Full Professor of Governance and Strategic Management at the Faculty of Economics and Business, University of Maribor, Slovenia. She is currently appointed as the Chair of the Department of Strategic Management and Business Policy at the Faculty of Economics and Business, University of Maribor. Research areas of her interest include Strategic Management, Corporate Governance, Integral Management; Start-up and Developmental Management, Business Planning, Governance and Management of Family Businesses, Developmental Particularities of Family Businesses, Dynamic Enterprise. She has published several articles in highly ranked journals and has been the author or co-author of books and books chapters. She has participated in research papers at several national and international conferences.",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSD2dQAG/Profile_Picture_1644907300283",totalCites:0,totalChapterViews:"0",outsideEditionCount:null,totalAuthoredChapters:"1",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:{name:"University of Maribor",institutionURL:null,country:{name:"Slovenia"}}},booksEdited:[],chaptersAuthored:[{id:"56123",title:"Corporate Governance Codes and Their Role in Improving Corporate Governance Practice",slug:"corporate-governance-codes-and-their-role-in-improving-corporate-governance-practice",abstract:"Good corporate governance (CG) is primarily the responsibility of every company, and both hard law and soft law should provide comprehensive corporate governance framework, thereby encouraging the introduction of high governance standards and best practices in the companies’ corporate governance system. The aim of this contribution is to broaden understanding on the role of codes of good governance in improving corporate governance practice on the case of Slovenia. The findings of research studies and analyses of the content of the Slovenian CG Code and its adoption in Slovenian companies show that the code has been playing an important role in developing corporate governance practice in Slovenia. Additionally, such analyses provide important cognitions on the adoption of the CG Code in Slovenian companies by revealing improvements in the governance practice and indicating those areas where changes are required. That is a way such monitoring and analyses should be done on the regular basis together with reporting on the monitoring results. This can considerably contribute to better understanding of the code’s recommendations among companies, promote debate and thus foster awareness of the underlying issues. Future analyses should address not only the statements on compliance but also how companies actually implement the code’s recommendations.",signatures:"Mojca Duh",authors:[{id:"202681",title:"Dr.",name:"Mojca",surname:"Duh",fullName:"Mojca Duh",slug:"mojca-duh",email:"mojca.duh@um.si"}],book:{id:"5968",title:"Corporate Governance and Strategic Decision Making",slug:"corporate-governance-and-strategic-decision-making",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"201486",title:"Ph.D.",name:"Paolo",surname:"Saona Hoffmann",slug:"paolo-saona-hoffmann",fullName:"Paolo Saona Hoffmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201486/images/6368_n.jpg",biography:"Paolo Saona is a Professor of Finance at John Cook School of Business, Saint Louis University in its campus of Madrid, Spain. He received his PhD at Universidad de Valladolid, Spain, and his MBA and BSc in Business at Universidad Austral de Chile. His research fields are international corporate finance, international corporate governance, capital structure decision, financial and regulatory systems, and banking systems. His research work has appeared in a number of international refereed scientific journals. He is a member of numerous international societies and served in the editorial board of several scientific journals. He has been awarded with research grants.",institutionString:null,institution:{name:"Saint Louis University",institutionURL:null,country:{name:"Spain"}}},{id:"201677",title:"Dr.",name:"Ana Paula P.",surname:"Costa",slug:"ana-paula-p.-costa",fullName:"Ana Paula P. Costa",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Institute of Economic Research Foundation",institutionURL:null,country:{name:"Brazil"}}},{id:"202532",title:"Dr.",name:"Ebru",surname:"Aykan",slug:"ebru-aykan",fullName:"Ebru Aykan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"202778",title:"Prof.",name:"George Yungchih",surname:"Wang",slug:"george-yungchih-wang",fullName:"George Yungchih Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202778/images/6078_n.jpg",biography:"Dr. George Y. Wang is currently an Associate Professor of Business and Economics at Soka University, Japan. He is also Adjunct Professor at Hosei University, Japan, Gakushuin University Japan, and Nagoya University of Commerce and Business, Japan. He is also appointed as Distinguished Scholar at Beijing University of Technology, China and Northwestern Polytechnic University, China. Prior to his position in Japan, he served as a faculty member for the University of Colorado Denver, USA and National Kaohsiung University of Applied Sciences, Taiwan. He received his MBA degree from the University of Connecticut, USA, and his Ph.D. degree from Imperial College London, UK. His research interests are focused on corporate finance, corporate governance, and investment appraisal. He has already published over 20 papers in academic journals and book chapters, indexed by academic databases including SCImago, EI, EconLit, CSSCI, ProQuest, and EBSCO. In addition to his current academic experience, Dr. Wang has rich industry experience, including serving as an Investment Analyst (Cathay Life Insurance Co., PLC), Consultant (UCome Consulting Company), Chief Financial Manager (Fen-Tay Enterprise Co., PLC), and Independent Board Director (Hwa-Toa Biochemical Co., Ltd.).",institutionString:null,institution:{name:"Soka University",institutionURL:null,country:{name:"Japan"}}},{id:"202880",title:"Dr.",name:"Alesia",surname:"Slocum",slug:"alesia-slocum",fullName:"Alesia Slocum",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"202881",title:"Dr.",name:"Laura",surname:"Muro",slug:"laura-muro",fullName:"Laura Muro",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"202882",title:"Dr.",name:"Gonzalo",surname:"Moreno",slug:"gonzalo-moreno",fullName:"Gonzalo Moreno",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"202902",title:"Dr.",name:"Alla",surname:"Mostepaniuk",slug:"alla-mostepaniuk",fullName:"Alla Mostepaniuk",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Girne American University",institutionURL:null,country:{name:"Cyprus"}}},{id:"202939",title:"Prof.",name:"Lilia",surname:"Dvorakova",slug:"lilia-dvorakova",fullName:"Lilia Dvorakova",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of West Bohemia",institutionURL:null,country:{name:"Czech Republic"}}},{id:"202940",title:"Dr.",name:"Olga",surname:"Faltejskova",slug:"olga-faltejskova",fullName:"Olga Faltejskova",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"publishing-process-steps",title:"Publishing Process Steps and Descriptions",intro:"
This is a brief overview of the main steps involved in publishing with IntechOpen Compacts, Monographs and Edited Books. Once you submit your proposal you will be appointed a Author Service Manager who will be your single point of contact and lead you through all the described steps below.
",metaTitle:"Publishing Process Steps and Descriptions",metaDescription:"This is a brief overview of the main steps involved in publishing with InTechOpen Compacts, Monographs and Edited Books. Once you submit your proposal you will be appointed a Publishing Process Manager who will be your single point of contact and lead you through all the described steps below.",metaKeywords:null,canonicalURL:"page/publishing-process-steps",contentRaw:'[{"type":"htmlEditorComponent","content":"
1. SEND YOUR PROPOSAL
\\n\\n
Please complete the publishing proposal form. The completed form should serve as an overview of your future Compacts, Monograph or Edited Book. Once submitted, your publishing proposal will be sent for evaluation, and a notice of acceptance or rejection will be sent within 10 to 30 working days from the date of submission.
\\n\\n
2. SUBMIT YOUR MANUSCRIPT
\\n\\n
After approval, you will proceed in submitting your full-length manuscript. 50-130 pages for compacts, 130-500 for Monographs & Edited Books.Your full-length manuscript must follow IntechOpen's Author Guidelines and comply with our publishing rules. Once the manuscript is submitted, but before it is forwarded for peer review, it will be screened for plagiarism.
\\n\\n
3. PEER REVIEW RESULTS
\\n\\n
External reviewers will evaluate your manuscript and provide you with their feedback. You may be asked to revise your draft, or parts of your draft, provide additional information and make any other necessary changes according to their comments and suggestions.
\\n\\n
4. ACCEPTANCE AND PRICE QUOTE
\\n\\n
If the manuscript is formally accepted after peer review you will receive a formal Notice of Acceptance, and a price quote.
\\n\\n
The Open Access Publishing Fee of your IntechOpen Compacts, Monograph or Edited Book depends on the volume of the publication and includes: project management, editorial and peer review services, technical editing, language copyediting, cover design and book layout, book promotion and ISBN assignment.
\\n\\n
We will send you your price quote and after it has been accepted (by both the author and the publisher), both parties will sign a Statement of Work binding them to adhere to the agreed upon terms.
\\n\\n
At this step you will also be asked to accept the Copyright Agreement.
\\n\\n
5. LANGUAGE COPYEDITING, TECHNICAL EDITING AND TYPESET PROOF
\\n\\n
Your manuscript will be sent to Straive, a leader in content solution services, for language copyediting. You will then receive a typeset proof formatted in XML and available online in HTML and PDF to proofread and check for completeness. The first typeset proof of your manuscript is usually available 10 days after its original submission.
\\n\\n
After we receive your proof corrections and a final typeset of the manuscript is approved, your manuscript is sent to our in house DTP department for technical formatting and online publication preparation.
\\n\\n
Additionally, you will be asked to provide a profile picture (face or chest-up portrait photograph) and a short summary of the book which is required for the book cover design.
\\n\\n
6. INVOICE PAYMENT
\\n\\n
The invoice is generally paid by the author, the author’s institution or funder. The payment can be made by credit card from your Author Panel (one will be assigned to you at the beginning of the project), or via bank transfer as indicated on the invoice. We currently accept the following payment options:
\\n\\n
\\n\\t
Credit Card
\\n\\t
PayPal
\\n\\t
Bank Transfer
\\n
\\n\\n
IntechOpen will help you complete your payment safely and securely, keeping your personal, professional and financial information safe.
\\n\\n
7. ONLINE PUBLICATION, PRINT AND DELIVERY OF THE BOOK
\\n\\n
IntechOpen authors can choose whether to publish their book online only or opt for online and print editions. IntechOpen Compacts, Monographs and Edited Books will be published on www.intechopen.com. If ordered, print copies are delivered by DHL within 12 to 15 working days.
\\n\\n
If you feel that IntechOpen Compacts, Monographs or Edited Books are the right publishing format for your work, please fill out the publishing proposal form. For any specific queries related to the publishing process, or IntechOpen Compacts, Monographs & Edited Books in general, please contact us at book.department@intechopen.com
Please complete the publishing proposal form. The completed form should serve as an overview of your future Compacts, Monograph or Edited Book. Once submitted, your publishing proposal will be sent for evaluation, and a notice of acceptance or rejection will be sent within 10 to 30 working days from the date of submission.
\n\n
2. SUBMIT YOUR MANUSCRIPT
\n\n
After approval, you will proceed in submitting your full-length manuscript. 50-130 pages for compacts, 130-500 for Monographs & Edited Books.Your full-length manuscript must follow IntechOpen's Author Guidelines and comply with our publishing rules. Once the manuscript is submitted, but before it is forwarded for peer review, it will be screened for plagiarism.
\n\n
3. PEER REVIEW RESULTS
\n\n
External reviewers will evaluate your manuscript and provide you with their feedback. You may be asked to revise your draft, or parts of your draft, provide additional information and make any other necessary changes according to their comments and suggestions.
\n\n
4. ACCEPTANCE AND PRICE QUOTE
\n\n
If the manuscript is formally accepted after peer review you will receive a formal Notice of Acceptance, and a price quote.
\n\n
The Open Access Publishing Fee of your IntechOpen Compacts, Monograph or Edited Book depends on the volume of the publication and includes: project management, editorial and peer review services, technical editing, language copyediting, cover design and book layout, book promotion and ISBN assignment.
\n\n
We will send you your price quote and after it has been accepted (by both the author and the publisher), both parties will sign a Statement of Work binding them to adhere to the agreed upon terms.
\n\n
At this step you will also be asked to accept the Copyright Agreement.
\n\n
5. LANGUAGE COPYEDITING, TECHNICAL EDITING AND TYPESET PROOF
\n\n
Your manuscript will be sent to Straive, a leader in content solution services, for language copyediting. You will then receive a typeset proof formatted in XML and available online in HTML and PDF to proofread and check for completeness. The first typeset proof of your manuscript is usually available 10 days after its original submission.
\n\n
After we receive your proof corrections and a final typeset of the manuscript is approved, your manuscript is sent to our in house DTP department for technical formatting and online publication preparation.
\n\n
Additionally, you will be asked to provide a profile picture (face or chest-up portrait photograph) and a short summary of the book which is required for the book cover design.
\n\n
6. INVOICE PAYMENT
\n\n
The invoice is generally paid by the author, the author’s institution or funder. The payment can be made by credit card from your Author Panel (one will be assigned to you at the beginning of the project), or via bank transfer as indicated on the invoice. We currently accept the following payment options:
\n\n
\n\t
Credit Card
\n\t
PayPal
\n\t
Bank Transfer
\n
\n\n
IntechOpen will help you complete your payment safely and securely, keeping your personal, professional and financial information safe.
\n\n
7. ONLINE PUBLICATION, PRINT AND DELIVERY OF THE BOOK
\n\n
IntechOpen authors can choose whether to publish their book online only or opt for online and print editions. IntechOpen Compacts, Monographs and Edited Books will be published on www.intechopen.com. If ordered, print copies are delivered by DHL within 12 to 15 working days.
\n\n
If you feel that IntechOpen Compacts, Monographs or Edited Books are the right publishing format for your work, please fill out the publishing proposal form. For any specific queries related to the publishing process, or IntechOpen Compacts, Monographs & Edited Books in general, please contact us at book.department@intechopen.com
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"6700",title:"Dr.",name:"Abbass A.",middleName:null,surname:"Hashim",slug:"abbass-a.-hashim",fullName:"Abbass A. Hashim",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/6700/images/1864_n.jpg",biography:"Currently I am carrying out research in several areas of interest, mainly covering work on chemical and bio-sensors, semiconductor thin film device fabrication and characterisation.\nAt the moment I have very strong interest in radiation environmental pollution and bacteriology treatment. The teams of researchers are working very hard to bring novel results in this field. I am also a member of the team in charge for the supervision of Ph.D. students in the fields of development of silicon based planar waveguide sensor devices, study of inelastic electron tunnelling in planar tunnelling nanostructures for sensing applications and development of organotellurium(IV) compounds for semiconductor applications. I am a specialist in data analysis techniques and nanosurface structure. I have served as the editor for many books, been a member of the editorial board in science journals, have published many papers and hold many patents.",institutionString:null,institution:{name:"Sheffield Hallam University",country:{name:"United Kingdom"}}},{id:"54525",title:"Prof.",name:"Abdul Latif",middleName:null,surname:"Ahmad",slug:"abdul-latif-ahmad",fullName:"Abdul Latif Ahmad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"20567",title:"Prof.",name:"Ado",middleName:null,surname:"Jorio",slug:"ado-jorio",fullName:"Ado Jorio",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidade Federal de Minas Gerais",country:{name:"Brazil"}}},{id:"47940",title:"Dr.",name:"Alberto",middleName:null,surname:"Mantovani",slug:"alberto-mantovani",fullName:"Alberto Mantovani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"12392",title:"Mr.",name:"Alex",middleName:null,surname:"Lazinica",slug:"alex-lazinica",fullName:"Alex Lazinica",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/12392/images/7282_n.png",biography:"Alex Lazinica is the founder and CEO of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his PhD studies in Robotics at the Vienna University of Technology. Here he worked as a robotic researcher with the university's Intelligent Manufacturing Systems Group as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and most importantly he co-founded and built the International Journal of Advanced Robotic Systems- world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career, since it was a pathway to founding IntechOpen - Open Access publisher focused on addressing academic researchers needs. Alex is a personification of IntechOpen key values being trusted, open and entrepreneurial. Today his focus is on defining the growth and development strategy for the company.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"19816",title:"Prof.",name:"Alexander",middleName:null,surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/19816/images/1607_n.jpg",biography:"Alexander I. Kokorin: born: 1947, Moscow; DSc., PhD; Principal Research Fellow (Research Professor) of Department of Kinetics and Catalysis, N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow.\r\nArea of research interests: physical chemistry of complex-organized molecular and nanosized systems, including polymer-metal complexes; the surface of doped oxide semiconductors. He is an expert in structural, absorptive, catalytic and photocatalytic properties, in structural organization and dynamic features of ionic liquids, in magnetic interactions between paramagnetic centers. The author or co-author of 3 books, over 200 articles and reviews in scientific journals and books. He is an actual member of the International EPR/ESR Society, European Society on Quantum Solar Energy Conversion, Moscow House of Scientists, of the Board of Moscow Physical Society.",institutionString:null,institution:{name:"Semenov Institute of Chemical Physics",country:{name:"Russia"}}},{id:"62389",title:"PhD.",name:"Ali Demir",middleName:null,surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62389/images/3413_n.jpg",biography:"Dr. Ali Demir Sezer has a Ph.D. from Pharmaceutical Biotechnology at the Faculty of Pharmacy, University of Marmara (Turkey). He is the member of many Pharmaceutical Associations and acts as a reviewer of scientific journals and European projects under different research areas such as: drug delivery systems, nanotechnology and pharmaceutical biotechnology. Dr. Sezer is the author of many scientific publications in peer-reviewed journals and poster communications. Focus of his research activity is drug delivery, physico-chemical characterization and biological evaluation of biopolymers micro and nanoparticles as modified drug delivery system, and colloidal drug carriers (liposomes, nanoparticles etc.).",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"61051",title:"Prof.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"100762",title:"Prof.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"St David's Medical Center",country:{name:"United States of America"}}},{id:"107416",title:"Dr.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Texas Cardiac Arrhythmia",country:{name:"United States of America"}}},{id:"64434",title:"Dr.",name:"Angkoon",middleName:null,surname:"Phinyomark",slug:"angkoon-phinyomark",fullName:"Angkoon Phinyomark",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/64434/images/2619_n.jpg",biography:"My name is Angkoon Phinyomark. I received a B.Eng. degree in Computer Engineering with First Class Honors in 2008 from Prince of Songkla University, Songkhla, Thailand, where I received a Ph.D. degree in Electrical Engineering. My research interests are primarily in the area of biomedical signal processing and classification notably EMG (electromyography signal), EOG (electrooculography signal), and EEG (electroencephalography signal), image analysis notably breast cancer analysis and optical coherence tomography, and rehabilitation engineering. I became a student member of IEEE in 2008. During October 2011-March 2012, I had worked at School of Computer Science and Electronic Engineering, University of Essex, Colchester, Essex, United Kingdom. In addition, during a B.Eng. I had been a visiting research student at Faculty of Computer Science, University of Murcia, Murcia, Spain for three months.\n\nI have published over 40 papers during 5 years in refereed journals, books, and conference proceedings in the areas of electro-physiological signals processing and classification, notably EMG and EOG signals, fractal analysis, wavelet analysis, texture analysis, feature extraction and machine learning algorithms, and assistive and rehabilitative devices. I have several computer programming language certificates, i.e. Sun Certified Programmer for the Java 2 Platform 1.4 (SCJP), Microsoft Certified Professional Developer, Web Developer (MCPD), Microsoft Certified Technology Specialist, .NET Framework 2.0 Web (MCTS). I am a Reviewer for several refereed journals and international conferences, such as IEEE Transactions on Biomedical Engineering, IEEE Transactions on Industrial Electronics, Optic Letters, Measurement Science Review, and also a member of the International Advisory Committee for 2012 IEEE Business Engineering and Industrial Applications and 2012 IEEE Symposium on Business, Engineering and Industrial Applications.",institutionString:null,institution:{name:"Joseph Fourier University",country:{name:"France"}}},{id:"55578",title:"Dr.",name:"Antonio",middleName:null,surname:"Jurado-Navas",slug:"antonio-jurado-navas",fullName:"Antonio Jurado-Navas",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",biography:"Antonio Jurado-Navas received the M.S. degree (2002) and the Ph.D. degree (2009) in Telecommunication Engineering, both from the University of Málaga (Spain). He first worked as a consultant at Vodafone-Spain. From 2004 to 2011, he was a Research Assistant with the Communications Engineering Department at the University of Málaga. In 2011, he became an Assistant Professor in the same department. From 2012 to 2015, he was with Ericsson Spain, where he was working on geo-location\ntools for third generation mobile networks. Since 2015, he is a Marie-Curie fellow at the Denmark Technical University. His current research interests include the areas of mobile communication systems and channel modeling in addition to atmospheric optical communications, adaptive optics and statistics",institutionString:null,institution:{name:"University of Malaga",country:{name:"Spain"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6602},{group:"region",caption:"Middle and South America",value:2,count:5908},{group:"region",caption:"Africa",value:3,count:2400},{group:"region",caption:"Asia",value:4,count:12542},{group:"region",caption:"Australia and Oceania",value:5,count:1008},{group:"region",caption:"Europe",value:6,count:17561}],offset:12,limit:12,total:132766},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"0",sort:"dateEndThirdStepPublish",topicId:"56121318 FILLER ads"},books:[],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:43},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:12},{group:"topic",caption:"Business, Management and Economics",value:7,count:4},{group:"topic",caption:"Chemistry",value:8,count:24},{group:"topic",caption:"Computer and Information Science",value:9,count:19},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:17},{group:"topic",caption:"Engineering",value:11,count:61},{group:"topic",caption:"Environmental Sciences",value:12,count:9},{group:"topic",caption:"Immunology and Microbiology",value:13,count:10},{group:"topic",caption:"Materials Science",value:14,count:29},{group:"topic",caption:"Mathematics",value:15,count:11},{group:"topic",caption:"Medicine",value:16,count:124},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:9},{group:"topic",caption:"Neuroscience",value:18,count:3},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:6},{group:"topic",caption:"Physics",value:20,count:12},{group:"topic",caption:"Psychology",value:21,count:9},{group:"topic",caption:"Robotics",value:22,count:3},{group:"topic",caption:"Social Sciences",value:23,count:9},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:3}],offset:12,limit:12,total:0},popularBooks:{featuredBooks:[],offset:0,limit:12,total:null},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[],latestBooks:[]},subject:{topic:{id:"208",title:"Material Science",slug:"nanotechnology-and-nanomaterials-material-science",parent:{id:"17",title:"Nanotechnology and Nanomaterials",slug:"nanotechnology-and-nanomaterials"},numberOfBooks:99,numberOfSeries:0,numberOfAuthorsAndEditors:2716,numberOfWosCitations:4236,numberOfCrossrefCitations:1964,numberOfDimensionsCitations:4612,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"208",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"11001",title:"Density Functional Theory",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"82d53383af78ab41eb982086c02fb2bb",slug:"density-functional-theory-recent-advances-new-perspectives-and-applications",bookSignature:"Daniel Glossman-Mitnik",coverURL:"https://cdn.intechopen.com/books/images_new/11001.jpg",editedByType:"Edited by",editors:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10779",title:"21st Century Nanostructured Materials",subtitle:"Physics, Chemistry, Classification, and Emerging Applications in Industry, Biomedicine, and Agriculture",isOpenForSubmission:!1,hash:"72c67f97f9bef68200df115b5fd79884",slug:"21st-century-nanostructured-materials-physics-chemistry-classification-and-emerging-applications-in-industry-biomedicine-and-agriculture",bookSignature:"Phuong V. Pham",coverURL:"https://cdn.intechopen.com/books/images_new/10779.jpg",editedByType:"Edited by",editors:[{id:"236073",title:"Dr.",name:"Phuong",middleName:"Viet",surname:"Pham",slug:"phuong-pham",fullName:"Phuong Pham"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10504",title:"Crystallization and Applications",subtitle:null,isOpenForSubmission:!1,hash:"3478d05926950f475f4ad2825d340963",slug:"crystallization-and-applications",bookSignature:"Youssef Ben Smida and Riadh Marzouki",coverURL:"https://cdn.intechopen.com/books/images_new/10504.jpg",editedByType:"Edited by",editors:[{id:"311698",title:"Dr.",name:"Youssef",middleName:null,surname:"Ben Smida",slug:"youssef-ben-smida",fullName:"Youssef Ben Smida"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10644",title:"Recent Developments in Atomic Force Microscopy and Raman Spectroscopy for Materials Characterization",subtitle:null,isOpenForSubmission:!1,hash:"30a4c22b98d8dd2b18e5c33dade4b94b",slug:"recent-developments-in-atomic-force-microscopy-and-raman-spectroscopy-for-materials-characterization",bookSignature:"Chandra Shakher Pathak and Samir Kumar",coverURL:"https://cdn.intechopen.com/books/images_new/10644.jpg",editedByType:"Edited by",editors:[{id:"318029",title:"Dr.",name:"Chandra Shakher",middleName:null,surname:"Pathak",slug:"chandra-shakher-pathak",fullName:"Chandra Shakher Pathak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10386",title:"Ionic Liquids",subtitle:"Thermophysical Properties and Applications",isOpenForSubmission:!1,hash:"e995617af1c5e63353ae91bbdac4c894",slug:"ionic-liquids-thermophysical-properties-and-applications",bookSignature:"S. M. Sohel Murshed",coverURL:"https://cdn.intechopen.com/books/images_new/10386.jpg",editedByType:"Edited by",editors:[{id:"24904",title:"Prof.",name:"S. M. Sohel",middleName:null,surname:"Murshed",slug:"s.-m.-sohel-murshed",fullName:"S. M. Sohel Murshed"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10281",title:"Nanopores",subtitle:null,isOpenForSubmission:!1,hash:"73c465d2d70f8deca04b05d7ecae26c4",slug:"nanopores",bookSignature:"Sadia Ameen, M. Shaheer Akhtar and Hyung-Shik Shin",coverURL:"https://cdn.intechopen.com/books/images_new/10281.jpg",editedByType:"Edited by",editors:[{id:"52613",title:"Dr.",name:"Sadia",middleName:null,surname:"Ameen",slug:"sadia-ameen",fullName:"Sadia Ameen"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9913",title:"Carbon Nanotubes",subtitle:"Redefining the World of Electronics",isOpenForSubmission:!1,hash:"43a22b8570e841b7a26d70159b2f755d",slug:"carbon-nanotubes-redefining-the-world-of-electronics",bookSignature:"Prasanta Kumar Ghosh, Kunal Datta and Arti Dinkarrao Rushi",coverURL:"https://cdn.intechopen.com/books/images_new/9913.jpg",editedByType:"Edited by",editors:[{id:"294687",title:"Dr.",name:"Prasanta",middleName:"Kumar",surname:"Ghosh",slug:"prasanta-ghosh",fullName:"Prasanta Ghosh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10479",title:"21st Century Advanced Carbon Materials for Engineering Applications",subtitle:"A Comprehensive Handbook",isOpenForSubmission:!1,hash:"712d04d43dbe1dca7dec9fcc08bc8852",slug:"21st-century-advanced-carbon-materials-for-engineering-applications-a-comprehensive-handbook",bookSignature:"Mujtaba Ikram and Asghari Maqsood",coverURL:"https://cdn.intechopen.com/books/images_new/10479.jpg",editedByType:"Edited by",editors:[{id:"286820",title:"Dr.",name:"Mujtaba",middleName:null,surname:"Ikram",slug:"mujtaba-ikram",fullName:"Mujtaba Ikram"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10411",title:"Materials at the Nanoscale",subtitle:null,isOpenForSubmission:!1,hash:"be29908600b7067c583ac21da1544a2d",slug:"materials-at-the-nanoscale",bookSignature:"Awadesh Kumar Mallik",coverURL:"https://cdn.intechopen.com/books/images_new/10411.jpg",editedByType:"Edited by",editors:[{id:"178218",title:"Dr.",name:"Awadesh",middleName:null,surname:"Mallik",slug:"awadesh-mallik",fullName:"Awadesh Mallik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10465",title:"Silver Micro-Nanoparticles",subtitle:"Properties, Synthesis, Characterization, and Applications",isOpenForSubmission:!1,hash:"dcc19a2b44c91940e16d82fd5eb8fffa",slug:"silver-micro-nanoparticles-properties-synthesis-characterization-and-applications",bookSignature:"Samir Kumar, Prabhat Kumar and Chandra Shakher Pathak",coverURL:"https://cdn.intechopen.com/books/images_new/10465.jpg",editedByType:"Edited by",editors:[{id:"296661",title:"Dr.",name:"Samir",middleName:null,surname:"Kumar",slug:"samir-kumar",fullName:"Samir Kumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10469",title:"Nanofibers",subtitle:"Synthesis, Properties and Applications",isOpenForSubmission:!1,hash:"28dc655dde01b94399cab954663f8bff",slug:"nanofibers-synthesis-properties-and-applications",bookSignature:"Brajesh Kumar",coverURL:"https://cdn.intechopen.com/books/images_new/10469.jpg",editedByType:"Edited by",editors:[{id:"176093",title:"Dr.",name:"Brajesh",middleName:null,surname:"Kumar",slug:"brajesh-kumar",fullName:"Brajesh Kumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10505",title:"Colloids",subtitle:"Types, Preparation and Applications",isOpenForSubmission:!1,hash:"55025219ea1a8b915ec8aa4b9f497a8d",slug:"colloids-types-preparation-and-applications",bookSignature:"Mohamed Nageeb Rashed",coverURL:"https://cdn.intechopen.com/books/images_new/10505.jpg",editedByType:"Edited by",editors:[{id:"63465",title:"Prof.",name:"Mohamed Nageeb",middleName:null,surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:99,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"50566",doi:"10.5772/63234",title:"Influences of Doping on Photocatalytic Properties of TiO2 Photocatalyst",slug:"influences-of-doping-on-photocatalytic-properties-of-tio2-photocatalyst",totalDownloads:5395,totalCrossrefCites:23,totalDimensionsCites:75,abstract:"As a kind of highly effective, low‐cost, and stable photocatalysts, TiO2 has received substantial public and scientific attention. However, it can only be activated under ultraviolet light irradiation due to its wide bandgap, high recombination, and weak separation efficiency of carriers. Doping is an effective method to extend the light absorption to the visible light region. In this chapter, we will address the importance of doping, different doping modes, preparation method, and photocatalytic mechanism in TiO2 photocatalysts. Thereafter, we will concentrate on Ti3+ self‐doping, nonmetal doping, metal doping, and codoping. Examples of progress can be given for each one of these four doping modes. The influencing factors of preparation method and doping modes on photocatalytic performance (spectrum response, carrier transport, interfacial electron transfer reaction, surface active sites, etc.) are summed up. The main objective is to study the photocatalytic processes, to elucidate the mechanistic models for a better understanding the photocatalytic reactions, and to find a method of enhancing photocatalytic activities.",book:{id:"5139",slug:"semiconductor-photocatalysis-materials-mechanisms-and-applications",title:"Semiconductor Photocatalysis",fullTitle:"Semiconductor Photocatalysis - Materials, Mechanisms and Applications"},signatures:"Fei Huang, Aihua Yan and Hui Zhao",authors:[{id:"178389",title:"Dr.",name:"Fei",middleName:null,surname:"Huang",slug:"fei-huang",fullName:"Fei Huang"},{id:"185126",title:"Dr.",name:"Aihua",middleName:null,surname:"Yan",slug:"aihua-yan",fullName:"Aihua Yan"},{id:"185127",title:"Ms.",name:"Hui",middleName:null,surname:"Zhao",slug:"hui-zhao",fullName:"Hui Zhao"}]},{id:"17184",doi:"10.5772/17039",title:"Polymer Nanocomposites: From Synthesis to Applications",slug:"polymer-nanocomposites-from-synthesis-to-applications",totalDownloads:17294,totalCrossrefCites:31,totalDimensionsCites:68,abstract:null,book:{id:"1045",slug:"nanocomposites-and-polymers-with-analytical-methods",title:"Nanocomposites and Polymers with Analytical Methods",fullTitle:"Nanocomposites and Polymers with Analytical Methods"},signatures:"S. Anandhan and S. Bandyopadhyay",authors:[{id:"27050",title:"Prof.",name:"Sri",middleName:null,surname:"Bandyopadhyay",slug:"sri-bandyopadhyay",fullName:"Sri Bandyopadhyay"},{id:"44992",title:"Prof.",name:"Anandhan",middleName:null,surname:"Srinivasan",slug:"anandhan-srinivasan",fullName:"Anandhan Srinivasan"}]},{id:"9725",doi:"10.5772/8508",title:"Biosynthesis and Application of Silver and Gold Nanoparticles",slug:"biosynthesis-and-application-of-silver-and-gold-nanoparticles",totalDownloads:27930,totalCrossrefCites:23,totalDimensionsCites:58,abstract:null,book:{id:"3621",slug:"silver-nanoparticles",title:"Silver Nanoparticles",fullTitle:"Silver Nanoparticles"},signatures:"Zygmunt Sadowski",authors:null},{id:"17194",doi:"10.5772/21694",title:"Properties of Nanofillers in Polymer",slug:"properties-of-nanofillers-in-polymer",totalDownloads:20390,totalCrossrefCites:9,totalDimensionsCites:56,abstract:null,book:{id:"1045",slug:"nanocomposites-and-polymers-with-analytical-methods",title:"Nanocomposites and Polymers with Analytical Methods",fullTitle:"Nanocomposites and Polymers with Analytical Methods"},signatures:"Damien M. Marquis, Éric Guillaume and Carine Chivas-Joly",authors:[{id:"44307",title:"Dr",name:"Damien",middleName:"Michel",surname:"Marquis",slug:"damien-marquis",fullName:"Damien Marquis"},{id:"44317",title:"Prof.",name:"Carine",middleName:null,surname:"Chivas-Joly",slug:"carine-chivas-joly",fullName:"Carine Chivas-Joly"}]},{id:"52860",doi:"10.5772/65937",title:"Cerium Oxide Nanostructures and their Applications",slug:"cerium-oxide-nanostructures-and-their-applications",totalDownloads:5377,totalCrossrefCites:24,totalDimensionsCites:58,abstract:"Due to excellent physical and chemical properties, cerium oxide (ceria, CeO2) has attracted much attention in recent years. This chapter aimed at providing some basic and fundamental properties of ceria, the importance of oxygen vacancies in this material, nano‐size effects and various synthesis strategies to form diverse structural morphologies. Finally, some key applications of ceria‐based nanostructures are reviewed. We conclude this chapter by expressing personal perspective on the probable challenges and developments of the controllable synthesis of CeO2 nanomaterials for various applications.",book:{id:"5510",slug:"functionalized-nanomaterials",title:"Functionalized Nanomaterials",fullTitle:"Functionalized Nanomaterials"},signatures:"Adnan Younis, Dewei Chu and Sean Li",authors:[{id:"191574",title:"Dr.",name:"Adnan",middleName:null,surname:"Younis",slug:"adnan-younis",fullName:"Adnan Younis"}]}],mostDownloadedChaptersLast30Days:[{id:"71103",title:"Preparation of Nanoparticles",slug:"preparation-of-nanoparticles",totalDownloads:3140,totalCrossrefCites:11,totalDimensionsCites:25,abstract:"Innovative developments of science and engineering have progressed very fast toward the synthesis of nanomaterials to achieve unique properties that are not the same as the properties of the bulk materials. The particle reveals interesting properties at the dimension below 100 nm, mostly from two physical effects. The two physical effects are the quantization of electronic states apparent leading to very sensitive size-dependent effects such as optical and magnetic properties and the high surface-to-volume ratio modifies the thermal, mechanical, and chemical properties of materials. The nanoparticles’ unique physical and chemical properties render them most appropriate for a number of specialist applications.",book:{id:"9109",slug:"engineered-nanomaterials-health-and-safety",title:"Engineered Nanomaterials",fullTitle:"Engineered Nanomaterials - Health and Safety"},signatures:"Takalani Cele",authors:[{id:"305934",title:"Dr.",name:"Takalani",middleName:null,surname:"Cele",slug:"takalani-cele",fullName:"Takalani Cele"}]},{id:"72636",title:"Nanocomposite Materials",slug:"nanocomposite-materials",totalDownloads:2139,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"Nanocomposites are the heterogeneous/hybrid materials that are produced by the mixtures of polymers with inorganic solids (clays to oxides) at the nanometric scale. Their structures are found to be more complicated than that of microcomposites. They are highly influenced by the structure, composition, interfacial interactions, and components of individual property. Most popularly, nanocomposites are prepared by the process within in situ growth and polymerization of biopolymer and inorganic matrix. With the rapid estimated demand of these striking potentially advanced materials, make them very much useful in various industries ranging from small scale to large to very large manufacturing units. With a great deal to mankind with environmental friendly, these offer advanced technologies in addition to the enhanced business opportunities to several industrial sectors like automobile, construction, electronics and electrical, food packaging, and technology transfer.",book:{id:"10072",slug:"nanotechnology-and-the-environment",title:"Nanotechnology and the Environment",fullTitle:"Nanotechnology and the Environment"},signatures:"Mousumi Sen",authors:[{id:"310218",title:"Dr.",name:"Mousumi",middleName:null,surname:"Sen",slug:"mousumi-sen",fullName:"Mousumi Sen"}]},{id:"38951",title:"Carbon Nanotube Transparent Electrode",slug:"carbon-nanotube-transparent-electrode",totalDownloads:3985,totalCrossrefCites:3,totalDimensionsCites:5,abstract:null,book:{id:"3077",slug:"syntheses-and-applications-of-carbon-nanotubes-and-their-composites",title:"Syntheses and Applications of Carbon Nanotubes and Their Composites",fullTitle:"Syntheses and Applications of Carbon Nanotubes and Their Composites"},signatures:"Jing Sun and Ranran Wang",authors:[{id:"153508",title:"Prof.",name:"Jing",middleName:null,surname:"Sun",slug:"jing-sun",fullName:"Jing Sun"},{id:"153596",title:"Ms.",name:"Ranran",middleName:null,surname:"Wang",slug:"ranran-wang",fullName:"Ranran Wang"}]},{id:"49413",title:"Electrodeposition of Nanostructure Materials",slug:"electrodeposition-of-nanostructure-materials",totalDownloads:3732,totalCrossrefCites:1,totalDimensionsCites:7,abstract:"We are conducting a multi-disciplinary research work that involves development of nanostructured thin films of semiconductors for different applications. Nanotechnology is widely considered to constitute the basis of the next technological revolution, following on from the first Industrial Revolution, which began around 1750 with the introduction of the steam engine and steelmaking. Nanotechnology is defined as the design, characterization, production, and application of materials, devices and systems by controlling shape and size of the nanoscale. The nanoscale itself is at present considered to cover the range from 1 to 100 nm. All samples prepared in thin film forms and the characterization revealed their nanostructure. The major exploitation of thin films has been in microelectronics, there are numerous and growing applications in communications, optical electronics, coatings of all kinds, and in energy generation. A great many sophisticated analytical instruments and techniques, largely developed to characterize thin films, have already become indispensable in virtually every scientific endeavor irrespective of discipline. Among all these techniques, electrodeposition is the most suitable technique for nanostructured thin films from aqueous solution served as samples under investigation. The electrodeposition of metallic layers from aqueous solution is based on the discharge of metal ions present in the electrolyte at a cathodic surface (the substrate or component.) The metal ions accept an electron from the electrically conducting material at the solid- electrolyte interface and then deposit as metal atoms onto the surface. The electrons necessary for this to occur are either supplied from an externally applied potential source or are surrendered by a reducing agent present in solution (electroless reduction). The metal ions themselves derive either from metal salts added to solution, or by the anodic dissolution of the so-called sacrificial anodes, made of the same metal that is to be deposited at the cathode.",book:{id:"4718",slug:"electroplating-of-nanostructures",title:"Electroplating of Nanostructures",fullTitle:"Electroplating of Nanostructures"},signatures:"Souad A. M. Al-Bat’hi",authors:[{id:"174793",title:"Dr.",name:"Mohamad",middleName:null,surname:"Souad",slug:"mohamad-souad",fullName:"Mohamad Souad"}]},{id:"71346",title:"Application of Nanomaterials in Environmental Improvement",slug:"application-of-nanomaterials-in-environmental-improvement",totalDownloads:1691,totalCrossrefCites:0,totalDimensionsCites:13,abstract:"In recent years, researchers used many scientific studies to improve modern technologies in the field of reducing the phenomenon of pollution resulting from them. In this chapter, methods to prepare nanomaterials are described, and the main properties such as mechanical, electrical, and optical properties and their relations are determined. The investigation of nanomaterials needed high technologies that depend on a range of nanomaterials from 1 to 100 nm; these are scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffractions (XRD). The applications of nanomaterials in environmental improvement are different from one another depending on the type of devices used, for example, solar cells for producing clean energy, nanotechnologies in coatings for building exterior surfaces, and sonochemical decolorization of dyes by the effect of nanocomposite.",book:{id:"10072",slug:"nanotechnology-and-the-environment",title:"Nanotechnology and the Environment",fullTitle:"Nanotechnology and the Environment"},signatures:"Ali Salman Ali",authors:[{id:"313275",title:"Associate Prof.",name:"Ali",middleName:null,surname:"Salman",slug:"ali-salman",fullName:"Ali Salman"}]}],onlineFirstChaptersFilter:{topicId:"208",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81438",title:"Research Progress of Ionic Thermoelectric Materials for Energy Harvesting",slug:"research-progress-of-ionic-thermoelectric-materials-for-energy-harvesting",totalDownloads:25,totalDimensionsCites:0,doi:"10.5772/intechopen.101771",abstract:"Thermoelectric material is a kind of functional material that can mutually convert heat energy and electric energy. It can convert low-grade heat energy (less than 130°C) into electric energy. Compared with traditional electronic thermoelectric materials, ionic thermoelectric materials have higher performance. The Seebeck coefficient can generate 2–3 orders of magnitude higher ionic thermoelectric potential than electronic thermoelectric materials, so it has good application prospects in small thermoelectric generators and solar power generation. According to the thermoelectric conversion mechanism, ionic thermoelectric materials can be divided into ionic thermoelectric materials based on the Soret effect and thermocouple effect. They are widely used in pyrogen batteries and ionic thermoelectric capacitors. The latest two types of ionic thermoelectric materials are in this article. The research progress is explained, and the problems and challenges of ionic thermoelectric materials and the future development direction are also put forward.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Jianwei Zhang, Ying Xiao, Bowei Lei, Gengyuan Liang and Wenshu Zhao"},{id:"77670",title:"Thermoelectric Elements with Negative Temperature Factor of Resistance",slug:"thermoelectric-elements-with-negative-temperature-factor-of-resistance",totalDownloads:72,totalDimensionsCites:0,doi:"10.5772/intechopen.98860",abstract:"The method of manufacturing of ceramic materials on the basis of ferrites of nickel and cobalt by synthesis and sintering in controllable regenerative atmosphere is presented. As the generator of regenerative atmosphere the method of conversion of carbonic gas is offered. Calculation of regenerative atmosphere for simultaneous sintering of ceramic ferrites of nickel and cobalt is carried out. It is offered, methods of the dilated nonequilibrium thermodynamics to view process of distribution of a charge and heat along a thermoelement branch. The model of a thermoelement taking into account various relaxation times of a charge and warmth is constructed.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Yuri Bokhan"},{id:"79236",title:"Processing Techniques with Heating Conditions for Multiferroic Systems of BiFeO3, BaTiO3, PbTiO3, CaTiO3 Thin Films",slug:"processing-techniques-with-heating-conditions-for-multiferroic-systems-of-bifeo3-batio3-pbtio3-catio",totalDownloads:96,totalDimensionsCites:0,doi:"10.5772/intechopen.101122",abstract:"In this chapter, we have report a list of synthesis methods (including both synthesis steps & heating conditions) used for thin film fabrication of perovskite ABO3 (BiFeO3, BaTiO3, PbTiO3 and CaTiO3) based multiferroics (in both single-phase and composite materials). The processing of high quality multiferroic thin film have some features like epitaxial strain, physical phenomenon at atomic-level, interfacial coupling parameters to enhance device performance. Since these multiferroic thin films have ME properties such as electrical (dielectric, magnetoelectric coefficient & MC) and magnetic (ferromagnetic, magnetic susceptibility etc.) are heat sensitive, i.e. ME response at low as well as higher temperature might to enhance the device performance respect with long range ordering. The magnetoelectric coupling between ferromagnetism and ferroelectricity in multiferroic becomes suitable in the application of spintronics, memory and logic devices, and microelectronic memory or piezoelectric devices. In comparison with bulk multiferroic, the fabrication of multiferroic thin film with different structural geometries on substrate has reducible clamping effect. A brief procedure for multiferroic thin film fabrication in terms of their thermal conditions (temperature for film processing and annealing for crystallization) are described. Each synthesis methods have its own characteristic phenomenon in terms of film thickness, defects formation, crack free film, density, chip size, easier steps and availability etc. been described. A brief study towards phase structure and ME coupling for each multiferroic system of BiFeO3, BaTiO3, PbTiO3 and CaTiO3 is shown.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Kuldeep Chand Verma and Manpreet Singh"},{id:"78034",title:"Quantum Physical Interpretation of Thermoelectric Properties of Ruthenate Pyrochlores",slug:"quantum-physical-interpretation-of-thermoelectric-properties-of-ruthenate-pyrochlores",totalDownloads:78,totalDimensionsCites:0,doi:"10.5772/intechopen.99260",abstract:"Lead- and lead-yttrium ruthenate pyrochlores were synthesized and investigated for Seebeck coefficients, electrical- and thermal conductivity. Compounds A2B2O6.5+z with 0 ≤ z < 0.5 were defect pyrochlores and p-type conductors. The thermoelectric data were analyzed using quantum physical models to identify scattering mechanisms underlying electrical (σ) and thermal conductivity (κ) and to understand the temperature dependence of the Seebeck effect (S). In the metal-like lead ruthenates with different Pb:Ru ratios, σ (T) and the electronic thermal conductivity κe (T) were governed by ‘electron impurity scattering’, the lattice thermal conductivity κL (T) by the 3-phonon resistive process (Umklapp scattering). In the lead-yttrium ruthenate solid solutions (Pb(2-x)YxRu2O(6.5±z)), a metal–insulator transition occurred at 0.2 moles of yttrium. On the metallic side (<0.2 moles Y) ‘electron impurity scattering’ prevailed. On the semiconductor/insulator side between x = 0.2 and x = 1.0 several mechanisms were equally likely. At x > 1.5 the Mott Variable Range Hopping mechanism was active. S (T) was discussed for Pb-Y-Ru pyrochlores in terms of the effect of minority carrier excitation at lower- and a broadening of the Fermi distribution at higher temperatures. The figures of merit of all of these pyrochlores were still small (≤7.3 × 10−3).",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Sepideh Akhbarifar"},{id:"77635",title:"Optimization of Thermoelectric Properties Based on Rashba Spin Splitting",slug:"optimization-of-thermoelectric-properties-based-on-rashba-spin-splitting",totalDownloads:125,totalDimensionsCites:0,doi:"10.5772/intechopen.98788",abstract:"In recent years, the application of thermoelectricity has become more and more widespread. Thermoelectric materials provide a simple and environmentally friendly solution for the direct conversion of heat to electricity. The development of higher performance thermoelectric materials and their performance optimization have become more important. Generally, to improve the ZT value, electrical conductivity, Seebeck coefficient and thermal conductivity must be globally optimized as a whole object. However, due to the strong coupling among ZT parameters in many cases, it is very challenging to break the bottleneck of ZT optimization currently. Beyond the traditional optimization methods (such as inducing defects, varying temperature), the Rashba effect is expected to effectively increase the S2σ and decrease the κ, thus enhancing thermoelectric performance, which provides a new strategy to develop new-generation thermoelectric materials. Although the Rashba effect has great potential in enhancing thermoelectric performance, the underlying mechanism of Rashba-type thermoelectric materials needs further research. In addition, how to introduce Rashba spin splitting into current thermoelectric materials is also of great significance to the optimization of thermoelectricity.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Zhenzhen Qin"},{id:"75364",title:"Challenges in Improving Performance of Oxide Thermoelectrics Using Defect Engineering",slug:"challenges-in-improving-performance-of-oxide-thermoelectrics-using-defect-engineering",totalDownloads:215,totalDimensionsCites:0,doi:"10.5772/intechopen.96278",abstract:"Oxide thermoelectric materials are considered promising for high-temperature thermoelectric applications in terms of low cost, temperature stability, reversible reaction, and so on. Oxide materials have been intensively studied to suppress the defects and electronic charge carriers for many electronic device applications, but the studies with a high concentration of defects are limited. It desires to improve thermoelectric performance by enhancing its charge transport and lowering its lattice thermal conductivity. For this purpose, here, we modified the stoichiometry of cation and anion vacancies in two different systems to regulate the carrier concentration and explored their thermoelectric properties. Both cation and anion vacancies act as a donor of charge carriers and act as phonon scattering centers, decoupling the electrical conductivity and thermal conductivity.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Jamil Ur Rahman, Gul Rahman and Soonil Lee"}],onlineFirstChaptersTotal:6},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:288,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{},subseries:{},overviewPageOFChapters:[],overviewPagePublishedBooks:[],openForSubmissionBooks:{},onlineFirstChapters:{},subseriesFiltersForOFChapters:[],publishedBooks:{},subseriesFiltersForPublishedBooks:[],publicationYearFilters:[],authors:{}},subseries:{item:{},onlineFirstChapters:{},publishedBooks:{},testimonialsList:[]},submityourwork:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/65719",hash:"",query:{},params:{id:"65719"},fullPath:"/chapters/65719",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var m;(m=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(m)}()