The species belonging to the four largest groups of
Abstract
Epsilonproteobacteria is a large group of Gram-negative curved or spiral microaerophilic rods, of which many are difficult to culture. Because this group of bacteria is not very well investigated, our knowledge about them is limited, and a great amount of research is still needed. At least two species are well-established human pathogens: Campylobacter jejuni/coli causing gastroenteritis and Helicobacter pylori causing gastric and extra-gastric manifestations. It is well accepted that H. pylori causes a chronic inflammation in the stomach and thereby causes H. pylori-associated gastritis, which may or may not be symptomatic. The association between H. pylori and peptic ulcers, MALT lymphomas, gastric cancer, idiopathic thrombocytopenic purpura, and unexplained iron-deficiency anemia (IDA) is strongly evidence based. On the other hand, pernicious (vitamin B12 deficiency) anemia, neuromyelitis optica, asthma, and Graves’ disease are less evidence based. H. pylori may also be associated with cardiovascular disease, pancreatitis, pancreatic cancer, obesity, diabetes mellitus type 2, Parkinson’s disease, liver diseases, and preeclampsia. H. pylori is thus involved in many gastric and extra-gastric manifestations either directly or indirectly by several proposed mechanisms including antigenic mimicry.
Keywords
- Helicobacter pylori
- infection
- mimicry
- gastritis
- anemia
- thrombocytopenic purpura
- gastric cancer
1. Introduction
Genus | Species |
---|---|
This chapter will focus on
Many microorganisms can cause autoimmune diseases. The mechanisms involved include molecular mimicry (when bacterial antigens cross-react with human tissue), epitope spreading, bystander effect, microbial superantigens, immune complex formation, MHC class II expression on nonimmune cells, and high levels of pro-inflammatory cytokines [14, 15, 16, 17].
All in all,
2. Gastritis and peptic ulcer
Whenever
Peptic ulcers occur in about 10% of patients infected with
3. Mucosa-associated lymphoid tissue (MALT) lymphomas
MALT lymphomas are a group of lymphomas which arise in the tissue normally devoid of lymphoid tissue, such as the stomach. These tissues accumulate lymphoid tissue during chronic antigenic stimulation such as chronic infections and autoimmune diseases.
4. Gastric cancer
The development of gastric cancer is a complex process that depends on
If
5. Idiopathic thrombocytopenic purpura (ITP)
Idiopathic thrombocytopenic purpura or immune thrombocytopenic purpura (ITP) is an acquired autoimmune disease resulting in the destruction of antibody-covered platelets and decreased platelet production. This results in an increased risk for bruising and bleeding. ITP is defined as a platelet count <100 × 109 /L, may be either primary or secondary, and is classified as acute, persistent, or chronic [36].
The mechanism that leads to ITP in
It is well established that
The most recent ITP guidelines from the American Society of Hematology (ASH) recommend eradication therapy in adult ITP patients with
6. Iron-deficiency anemia
A meta-analysis comprising 15,183 patients from 20 studies found an association between
On the other hand, Herschko et al. studied 160 patients with autoimmune gastritis, of whom 83 presented with IDA [47]. When stratifying by age, they found a decreasing prevalence of coexistent
The British Society of Gastroenterology recommends noninvasive testing and antibiotic treatment for
7. Vitamin B12 deficiency anemia
Vitamin B12 (cobalamin) deficiency is estimated to affect approximately 10–15% of the population older than 60 years. There are several causes where pernicious anemia and food-cobalamin malabsorption are the most common reasons. Cobalamin is obtained primarily from food through a complicated process where an acidic environment releases cobalamin from food and thereafter binds to intrinsic factors secreted from parietal cells and finally is absorbed by specific receptors in the terminal ileum. Pernicious anemia is an autoimmune disorder consisting of chronic atrophic gastritis, decreased acid secretion, and antibodies directed against parietal cells and/or intrinsic factors, thereby leading to decreased cobalamin absorption.
As mentioned above, it has been proposed that B12 deficiency can arise as the result of a late phase of
The literature regarding the association between
8. Cardiovascular disease
Studies indicate an association between
9. Pancreatitis and pancreatic cancer
Studies have shown a correlation between increased antibody levels to
10. Obesity and diabetes mellitus type 2
Obesity is becoming a worldwide problem, and population studies have shown that in the same areas where the prevalence of
Ghrelin is a hormone mainly produced by endocrine cells in the gastrointestinal mucosa and is released to the surroundings. This molecule is important for stimulating food intake and weight gain [69]. The damages that
Ghrelin also seems to play a role in fat metabolism and glucose homeostasis, which can lead to a cross-reaction between lipid and glucose metabolisms that may result in insulin resistance [71]. However, one thing is clear, diabetes mellitus type 2 is a multifactorial disease, and
Although many studies have shown that there could be a correlation between
11. Parkinson’s and Alzheimer’s diseases
Numerous studies indicate that
12. Neuromyelitis optica
Several studies have shown a correlation between
13. Asthma
The prevalence of asthma is increasing in areas where the prevalence of
14. Hepatobiliary diseases
Non-pylori
15. Autoimmune thyroid diseases
Both Graves’ disease and Hashimoto’s thyroiditis are autoimmune diseases in the thyroid. Graves’ disease is characterized by hyperthyroidism and an enlarged gland, while Hashimoto’s thyroiditis is characterized by hypothyroidism and the destruction of thyroid tissue. There is an association between Graves’ disease and
16. Preeclampsia
The first study investigating the association between
A review from 2014 concluded that there is evidence indicating that
17. Discussion
The role of
As with many other infections,
Weaker associations between
In conclusion, a variety of diseases may be caused by
18. Conclusion
A variety of diseases are may be caused by
Conflict of interest
The authors declare that they have no conflict of interest.
Abbreviations
CVD | cardiovascular disease |
CagA | cytotoxin-associated gene A |
H. pylori | Helicobacter pylori |
IDA | iron-deficiency anemia |
ITP | idiopathic thrombocytopenic purpura |
MALT | mucosa-associated lymphoid tissue |
NMO | neuromyelitis optica |
OR | odds ratio |
PAF | platelet-activating factor |
PE | preeclampsia |
Treg | regulatory T cells |
VacA | vacuolating toxin |
References
- 1.
Campbell BJ, Engel AS, Porter ML, et al. The versatile ε-proteobacteria: Key players in sulphidic habitats. Nature Reviews. Microbiology. 2006; 4 (6):458-468 - 2.
Engberg J, On SL, Harrington CS, et al. Prevalence of Campylobacter, Arcobacter, Helicobacter, andSutterella spp . in human fecal samples as estimated by a reevaluation of isolation methods for Campylobacters. Journal of Clinical Microbiology. 2000;38 (1):286-291 - 3.
Cornelius AJ, Chambers S, Aitken J, et al. Epsilonproteobacteria in humans, New Zealand. Emerging Infectious Diseases. 2012; 18 (3):510-512 - 4.
Maher M, Finnegan C, Collins E, et al. Evaluation of culture methods and a DNA probe-based PCR assay for detection of Campylobacter species in clinical specimens of feces. Journal of Clinical Microbiology. 2003;41 (7):2980-2986 - 5.
Cover TL, Blaser MJ. Helicobacter pylori in health and disease. Gastroenterology. 2009;136 (6):1863-1873 - 6.
Andersen LP. New Helicobacter species in humans. Digestive Diseases. 2001;19 (2):112-115 - 7.
Andersen LP. Colonization and infection by Helicobacter pylori in Humans. Helicobacter. 2007;12 (s2):12-15 - 8.
Mobley HLT. Helicobacter pylori Factors associated with disease development. Gastroenterology. 1997;113 (6):S21-S28 - 9.
Andersen LP, Boye K, Blom J, et al. Characterization of a culturable “ Gastrospirillum hominis” (Helicobacter heilmannii ) strain isolated from human gastric mucosa. Journal of Clinical Microbiology. 1999;37 (4):1069-1076 - 10.
Kim N. Helicobacter pylori . Springer Singapore: Singapore; 2016 - 11.
Holck S, Ingeholm P, Blom J, et al. The histopathology of human gastric mucosa inhabited by Helicobacter heilmannii -like (Gastrospirillum hominis ) organisms, including the first culturable case. Acta Pathologica, Microbiologica, et Immunologica Scandinavica. 1997;105 (7-12):746-756 - 12.
Kobayashi M, Lee H, Nakayama J, et al. Roles of gastric mucin-type O-glycans in the pathogenesis of Helicobacter pylori infection. Glycobiology. 2009;19 (5):453-461 - 13.
Chmiela M, Gonciarz W. Molecular mimicry in Helicobacter pylori infections. World Journal of Gastroenterology. 2017;23 (22):3964-3977 - 14.
Vial T, Descotes J. Autoimmune diseases and vaccinations. European Journal of Dermatology. 2004; 14 (2):86-90 - 15.
McCoy L, Tsunoda I, Fujinami RS. Multiple sclerosis and virus induced immune responses: Autoimmunity can be primed by molecular mimicry and augmented by bystander activation. Autoimmunity. 2006; 39 (1):9-19 - 16.
Ram M, Shoenfeld Y. Hepatitis B: Infection, vaccination and autoimmunity. IMAJ. 2008; 10 :61-64 - 17.
Ravel G, Christ M, Horand F, et al. Autoimmunity, environmental exposure and vaccination: Is there a link? Toxicology. 2004; 196 (3):211-216 - 18.
Smyk DS, Koutsoumpas AL, Mytilinaiou MG, et al. Helicobacter pylori and autoimmune disease: Cause or bystander. World Journal of Gastroenterology. 2014;20 (3):613-629 - 19.
Hagymási K, Tulassay Z. Helicobacter pylori infection: New pathogenetic and clinical aspects. World Journal of Gastroenterology. 2014;20 (21):6386-6399 - 20.
Malfertheiner P, Michetti P, Price A. Helicobacter pylori : An Atlas. 1st ed. Science Press; 1996 - 21.
Malfertheiner P, Megraud F, Morain CAO, et al. Management of Helicobacter pylori infection—the Maastricht V/Florence consensus report. Gut. 2017;66 :6-30 - 22.
Chan FKL, To KF, Wu JCY, et al. Randomised trial of eradication of Helicobacter pylori before non-steroidal anti-inflammatory drug therapy to prevent peptic ulcers. Lancet. 1997;350 (9083):975-979 - 23.
Kalia N, Bardhan KD, Reed MWR, et al. Mechanisms of Helicobacter pylori -induced rat gastric mucosal microcirculatory disturbances in vivo. Digestive Diseases and Sciences. 2000;45 (4):763-772 - 24.
Smolka AJ, Schubert ML. Helicobacter pylori -induced changes in gastric acid secretion and upper gastrointestinal disease. Current Topics in Microbiology and Immunology. 2017;400 :227-252 - 25.
Stathis A, Chini C, Bertoni F, et al. Long-term outcome following Helicobacter pylori eradication in a retrospective study of 105 patients with localized gastric marginal zone B-cell lymphoma of MALT type. Annals of Oncology. 2009;20 (6):1086-1093 - 26.
Floch P, Mégraud F, Lehours P. Helicobacter pylori strains and gastric MALT lymphoma. Toxins. 2017;9 (4):132 - 27.
Hasni S, Ippolito A, Illei G. Helicobacter pylori and autoimmune diseases. Oral Diseases. 2011;17 (7):621-627 - 28.
Øverby A, Murayama SY, Michimae H, et al. Prevalence of gastric non- Helicobacter pylori-Helicobacters in Japanese patients with gastric disease. Digestion. 2017;95 (1):61-66 - 29.
Morgner A, Lehn N, Andersen LP, et al. Helicobacter heilmannii –associated primary gastric low-grade MALT lymphoma: Complete remission after curing the infection. Gastroenterology. 2000;118 (5):821-828 - 30.
Park J, Greenberg E, Parsonnet J, et al. Summary of IARC working group meeting on Helicobacter pylori eradication as a strategy for preventing gastric cancer. IARC Work Group Report. 2014;8 :1-4 - 31.
Stein M, Rappuoli R, Covacci A. Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation. Proceedings of the National Academy of Sciences of the United States of America. 2000;97 (3):1263-1268 - 32.
Stein M, Bagnoli F, Halenbeck R, et al. c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs. Molecular Microbiology. 2002;43 (4):971-980 - 33.
Cover TL, Peek RM Jr. Diet, microbial virulence, and Helicobacter pylori -induced gastric cancer. Gut Microbes. 2013;4 (6):482-493 - 34.
Armstrong H, Bording-Jorgensen M, Dijk S, et al. The complex interplay between chronic inflammation, the microbiome, and cancer: Understanding disease progression and what we can do to prevent it. Cancers. 2018; 10 (3):83 - 35.
Malfertheiner P, Sipponen P, Naumann M, et al. Helicobacter pylori eradication has the potential to prevent gastric cancer: A state-of-the-art critique. The American Journal of Gastroenterology. 2005;100 (9):2100-2115 - 36.
Neunert C, Lim W, Crowther M, et al. The american society of hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood. 2011; 117 (16):4190-4207 - 37.
Takahashi T, Yujiri T, Inoue Y, et al. Molecular mimicry by Helicobacter pylori CagA protein may be involved in the pathogenesis ofH. pylori -associated chronic idiopathic thrombocytopenic purpura. British Journal of Haematology. 2004;124 :91-96 - 38.
Stasi R, Sarpatwari A, Segal JB, et al. Effects of eradication of Helicobacter pylori infection in patients with immune thrombocytopenic purpura: A systematic review. Blood. 2008;113 :1231-1240 - 39.
Kim H, Lee W, Lee K, et al. Efficacy of Helicobacter pylori eradication for the 1st line treatment of immune thrombocytopenia patients with moderate thrombocytopenia. Annals of Hematology. 2015;94 :739-746 - 40.
Shino H, Brito H, Aparecida J, et al. Helicobacter pylori infection and immune thrombocytopenic purpura in children and adolescents: A randomized controlled trial. Platelets. 2015;26 (4):336-341 - 41.
Jones NL, Koletzko S, Goodman K, et al. Joint ESPGHAN/NASPGHAN guidelines for the management of Helicobacter pylori in children and adolescents. Journal of Pediatric Gastroenterology and Nutrition. 2017;64 (6):991-1003 - 42.
Cardenas VM, Mulla ZD, Ortiz M, et al. Iron deficiency and Helicobacter pylori infection in the United States. American Journal of Epidemiology. 2018;163 (2):127-134 - 43.
Dubois S, Kearney DJ. Iron-deficiency anemia and Helicobacter pylori infection: A review of the evidence. The American Journal of Gastroenterology. 2005;100 :453-459 - 44.
Milman N, Rosenstock S, Andersen L, et al. Serum ferritin, hemoglobin, and Helicobacter pylori infection: A seroepidemiologic survey comprising 2794 Danish adults. Gastroenterology. 1998;115 :268-274 - 45.
Papagiannakis P, Michalopoulos C, Papalexi F, et al. The role of Helicobacter pylori infection in hematological disorders. European Journal of Internal Medicine. 2018;24 (8):685-690 - 46.
Qu X, Huang X, Xiong P, et al. Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis. World Journal of Gastroenterology. 2010;16 (7):886-896 - 47.
Hershko C, Ronson A, Souroujon M, et al. Variable hematologic presentation of autoimmune gastritis: Age-related progession from iron deficiency to cobalamin depletion. Blood. 2006; 107 :1673-1679 - 48.
Goddard AF, James MW, Mcintyre AS, et al. Guidelines for the management of iron deficiency anaemia. Gut. 2011; 60 :1309-1316 - 49.
Chey WD, Leontiadis GI, Howden CW, et al. CME ACG clinical guideline: Treatment of Helicobacter pylori infection. The American Journal of Gastroenterology. 2017;112 (2):212-239 - 50.
Stopeck A. Links between Helicobacter pylori infection, cobalamin deficiency, and pernicious anemia. Archives of Internal Medicine. 2000;160 :1229-1230 - 51.
DeLuca VA. Helicobacter pylori gastric atrophy and pernicious anemia. Gastroenterology. 1992;102 (2):744-745 - 52.
Kaptan K, Beyan C, Ural AU, et al. Helicobacter pylori —Is it a novel causative agent in vitamin B12 deficiency? Archives of Internal Medicine. 2000;160 (9):1349 - 53.
Kucukazman M, Yeniova O, Dal K, et al. Helicobacter pylori and cardiovascular disease. European Review for Medical and Pharmacological Sciences. 2015;19 (19):3731-3741 - 54.
Sharma V, Aggarwal A. Helicobacter pylori : Does it add to risk of coronary artery disease. World Journal of Cardiology. 2015;7 (1):19 - 55.
Lee M, Baek H, Park JS, et al. Current Helicobacter pylori infection is significantly associated with subclinical coronary atherosclerosis in healthy subjects: A cross-sectional study. PLoS One. 2018;13 (3):e0193646 - 56.
Jukic A, Bozic D, Kardum D, et al. Helicobacter pylori infection and severity of coronary atherosclerosis in patients with chronic coronary artery disease. Therapeutics and Clinical Risk Management. 2017;13 :933-938 - 57.
Sagud M, Vlatkovic S, Strac DS, et al. Latent Toxoplasma gondi i infection is associated with decreased serum triglyceride to high-density lipoprotein cholesterol ratio in male patients with schizophrenia. Comprehensive Psychiatric Care. 2018;82 :115-120 - 58.
Kelesidis T, Oda MN, Borja MS, et al. Predictors of impaired HDL function in HIV-1 infected compared to uninfected individuals. The Journal of Acquired Immune Deficiency Syndromes. 2017; 75 (3):354-363 - 59.
Sayyahfar S, Davoodzadeh F, Hoseini R, et al. Comparison of tuberculin skin test and interferon gamma release assay for diagnosis of latent tuberculosis infection in pediatric candidates of renal transplantation. Pediatric Transplantation. 2018; 22 (2):e13148 - 60.
Bulajic M, Panic N, Löhr JM. Helicobacter pylori and pancreatic diseases. World Journal of Gastrointest Pathophysiology. 2014;5 (4):380-383 - 61.
Raderer M, Wrba F, Kornek G, et al. Association between Helicobacter pylori infection and pancreatic cancer. Oncology. 1998;55 (16):16-19 - 62.
Stolzenberg-Solomon RZ, Blaser MJ, Limburg PJ, et al. Helicobacter pylori seropositivity as a risk factor for pancreatic cancer. The Journal of the National Cancer Institute. 2001;93 (12):937-941 - 63.
Rabelo-Gonçalves EM, Roesler BM, Zeitune JM. Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases. World Journal of Hepatology. 2015;7 (30):2968-2979 - 64.
Haarstad H, Petersen H. Short- and long-term effects of secretin and a cholecystokinin-like peptide on pancreatic growth and synthesis of RNA and polyamines. Scandinavian Journal of Gastroenterology. 1989; 24 (6):721-732 - 65.
Culver EL, Smit WL, Evans C, et al. No evidence to support a role for Helicobacter pylori infection and plasminogen binding protein in autoimmune pancreatitis and IgG4- related disease in a UK cohort. Pancreatology. 2017;17 :395-402 - 66.
Ioannou GN, Weiss NS, Kearney DJ. Is Helicobacter pylori seropositivity related to body mass index in the United States? Alimentary Pharmacology and Therapeutics. 2005;21 :765-772 - 67.
Osawa H, Nakazato M, Date Y, et al. Impaired production of gastric ghrelin in chronic gastritis associated with Helicobacter pylori . The Journal of Clinical Endocrinology and Metabolism. 2005;90 (1):10-16 - 68.
Nwokolo CU, Freshwater DA, O’Hare P, et al. Plasma ghrelin following cure of Helicobacter pylori . Gut. 2003;52 (5):637-640 - 69.
Sakata I, Sakai T. Ghrelin cells in the gastrointestinal tract. International Journal of Peptide. 2010; 2010 :1-7 - 70.
Tatsuguchi A, Miyake K, Gudis K, et al. Effect of Helicobacter pylori infection on ghrelin expression in human gastric mucosa. The American Journal of Gastroenterology. 2004;99 (11):2121-2127 - 71.
Churm R, Davies J, Stephens J, et al. Ghrelin function in human obesity and type 2 diabetes: A concise review. Obesity Reviews. 2017; 18 (2):140-148 - 72.
Wong F, Rayner-Hartley E, Byrne MF. Extraintestinal manifestations of Helicobacter pylori : A concise review. World Journal of Gastroenterology. 2014;20 (34):11950-11961 - 73.
He C, Yang Z, Lu N-H. Helicobacter pylori infection and diabetes: Is it a myth or fact? World Journal of Gastroenterology. 2014;20 (16):4607-4617 - 74.
Loffeld RJLF. Helicobacter pylori , obesity and gastro-oesophageal reflux disease. Is there a relation? A personal view. The Netherlands Journal of Medicine. 2005;63 (9):344-347 - 75.
Kountouras J, Boziki M, Gavalas E, et al. Eradication of Helicobacter pylori may be beneficial in the management of Alzheimer’s disease. Journal of Neurology. 2009;256 (5):758-767 - 76.
Malaguarnera M, Bella R, Alagona G, et al. Helicobacter pylori and Alzheimer’s disease: A possible link. European Journal of Internal Medicine. 2004;15 (6):381-386 - 77.
Roubaud-Baudron C, Krolak-Salmon P, Quadrio I, et al. Impact of chronic Helicobacter pylori infection on Alzheimer’s disease: Preliminary results. Neurobiology of Aging. 2012;33 :1009.e11-1009.e19 - 78.
Kountouras J, Boziki M, Zavos C, et al. A potential impact of chronic Helicobacter pylori infection on Alzheimer’s disease pathobiology and course. Neurobiology of Aging. 2012;33 :e3-e4 - 79.
Weller C, Charlett A, Oxlade NL, et al. Role of chronic infection and inflammation in the gastrointestinal tract in the etiology and pathogenesis of idiopathic parkinsonism. Part 3: predicted probability and gradients of severity of idiopathic parkinsonism based on H. pylori antibody profile. Helicobacter. 2005;10 (4):288-297 - 80.
Tradtrantip L, Zhang H, Saadoun S, et al. Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica. Annals of Neurology. 2012; 71 (3):314-322 - 81.
Chen Y, Blaser MJ. Inverse associations of Helicobacter pylori with asthma and allergy. Archives of Internal Medicine. 2007;167 (8):821 - 82.
Pacifico L, Osborn JF, Tromba V, et al. Helicobacter pylori infection and extragastric disorders in children: A critical update. World Journal of Gastroenterology. 2014;20 (6):1379-1401 - 83.
Zhou X, Wu J, Zhang G. Association between Helicobacter pylori and asthma: A meta-analysis. European Journal of Gastroenterology and Hepatology. 2013;25 (4):460-468 - 84.
D’Elios MM, Codolo G, Amedei A, et al. Helicobacter pylori , asthma and allergy. FEMS Immunology and Medical Microbiology. 2009;56 (1):1-8 - 85.
Arnold IC, Dehzad N, Reuter S, et al. Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells. The Journal of Clinical Investigation. 2011;121 (8):3088-3093 - 86.
Fox JG, Yan LL, Dewhirst FE, et al. Helicobacter bilis sp. nov., a novelHelicobacter species isolated from bile, livers, and intestines of aged, inbred mice. The Journal of Clinical Microbiology. 1995;33 (2):445-454 - 87.
Fox JG, Yan L, Shames B, et al. Persistent hepatitis and enterocolitis in germfree mice infected with Helicobacter hepaticus . Infection and Immunity. 1996;64 (9):3673-3681 - 88.
Franklin CL, Beckwith CS, Livingston RS, et al. Isolation of a novel Helicobacter species,Helicobacter cholecystus sp. nov., from the gallbladders of Syrian hamsters with cholangiofibrosis and centrilobular pancreatitis. Journal of Clinical Microbiology. 1996;34 (12):2952-2958 - 89.
Al-Soud WA, Stenram U, Ljungh A, et al. DNA of Helicobacter spp. and common gut bacteria in primary liver carcinoma. Digestive and Liver Disease. 2008;40 :126-131 - 90.
Kobayashi T, Harada K, Miwa K, et al. Helicobacter genus DNA fragments are commonly detectable in bile from patients with extrahepatic biliary diseases and associated with their pathogenesis. Digestive Diseases and Sciences. 2005;50 (5):862-867 - 91.
Fukuda K, Kuroki T, Tajima Y, et al. Comparative analysis of Helicobacter DNAs and biliary pathology in patients with and without hepatobiliary cancer. Carcinogenesis. 2002;23 (11):1927-1932 - 92.
Segura-López FK, Güitrón-Cantú A, Torres J. Association between Helicobacter spp. infections and hepatobiliary malignancies: A review. World Journal of Gastroenterology. 2015;21 (5):1414-1423 - 93.
Amodio P, Montagnese S, Gatta A, et al. Characteristics of minimal hepatic encephalopathy. Metabolic Brain Disease. 2004; 19 (3/4):253-267 - 94.
Holzinger F, Z’graggen K, Büchler MW. Mechanisms of biliary carcinogenesis: A pathogenetic multi-stage cascade towards cholangiocarcinoma. Annals of Oncology. 1999; 10 :122-126 - 95.
Bassi V, Marino G, Iengo A, et al. Autoimmune thyroid diseases and Helicobacter pylori : The correlation is present only in Graves’s disease. World Journal of Gastroenterology. 2012;18 (10):1093-1097 - 96.
Bertalot G, Montresor G, Tampieri M, et al. Decrease in thyroid autoantibodies after eradication of Helicobacter pylori infection. Clinical Endocrinology. 2004;61 (5):650-652 - 97.
Abenavoli L, Arena V, Giancotti F, et al. Celiac disease, primary biliary cirrhosis and Helicobacter pylori infection: One link for three diseases. International Journal of Immunopathology and Pharmacology. 2010;23 (4):1261-1265 - 98.
Ponzetto A, Cardaropoli S, Piccoli E, et al. Pre-eclampsia is associated with Helicobacter pylori seropositivity in Italy. Journal of Hypertension. 2006;24 (12):2445-2449 - 99.
Moretti E, Figura N, Collodel G, et al. Can Helicobacter pylori infection influence human reproduction? World Journal of Gastroenterology. 2014;20 (19):5567-5574 - 100.
Bellos I, Daskalakis G, Pergialiotis V. Helicobacter pylori infection increases the risk of developing preeclampsia: A meta-analysis of observational studies. International Journal of Clinical Practice. 2018;72 (2):e13064 - 101.
Shiadeh MN, Moghadam ZB, Adam I, et al. Human infectious diseases and risk of preeclampsia: An updated review of the literature. Infection. 2017; 45 (5):589-600 - 102.
Parte AC. LPSN—list of prokaryotic names with standing in nomenclature. Nucleic Acids Research. 2014; 42 (D1):D613-D616 - 103.
Zhang R-G et al. Role of Helicobacter pylori infection in pathogenesis of gastric carcinoma. The World Journal of Gastrointestinal Pathophysiology. 2016; 7 (1):97-107 - 104.
Álvarez-Arellano L, Maldonado-Bernal C. Helicobacter pylori and neurological diseases: Married by the laws of inflammation. The World Journal of Gastrointestinal Pathophysiology. 2014; 5 (4):400-404 - 105.
Chiela M, Conciarz W, et al. Molecular mimicry in Helicobacter pylori infections. World Journal of Gastroenterology. 2017; 23 :3964-3977