Characteristics and attributes of software agents.
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"469",leadTitle:null,fullTitle:"Carbon Nanotubes - From Research to Applications",title:"Carbon Nanotubes",subtitle:"From Research to Applications",reviewType:"peer-reviewed",abstract:"Since their discovery in 1991, carbon nanotubes have been considered as one of the most promising materials for a wide range of applications, in virtue of their outstanding properties. During the last two decades, both single-walled and multi-walled CNTs probably represented the hottest research topic concerning materials science, equally from a fundamental and from an applicative point of view. There is a prevailing opinion among the research community that CNTs are now ready for application in everyday world. This book provides an (obviously not exhaustive) overview on some of the amazing possible applications of CNT-based materials in the near future.",isbn:null,printIsbn:"978-953-307-500-6",pdfIsbn:"978-953-51-5567-6",doi:"10.5772/981",price:139,priceEur:155,priceUsd:179,slug:"carbon-nanotubes-from-research-to-applications",numberOfPages:370,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:null,bookSignature:"Stefano Bianco",publishedDate:"July 20th 2011",coverURL:"https://cdn.intechopen.com/books/images_new/469.jpg",numberOfDownloads:75294,numberOfWosCitations:106,numberOfCrossrefCitations:55,numberOfCrossrefCitationsByBook:9,numberOfDimensionsCitations:132,numberOfDimensionsCitationsByBook:11,hasAltmetrics:1,numberOfTotalCitations:293,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 12th 2010",dateEndSecondStepPublish:"November 9th 2010",dateEndThirdStepPublish:"March 16th 2011",dateEndFourthStepPublish:"April 15th 2011",dateEndFifthStepPublish:"June 14th 2011",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"32081",title:"Dr.",name:"Stefano",middleName:null,surname:"Bianco",slug:"stefano-bianco",fullName:"Stefano Bianco",profilePictureURL:"https://mts.intechopen.com/storage/users/32081/images/1748_n.jpg",biography:"Dr. Stefano Bianco received his Master’s Degree in Physics from the University of Turin, Italy, in 2003 and his Ph.D. in Electronic Devices from Polytechnic University of Turin, Italy, in 2007. He was a postdoctoral fellow (2007 - 2009) at the Physics Department of the Polytechnic University of Turin, working on carbon nanotube synthesis, characterization and application. Currently he is a researcher of the Italian Institute of Technology, working on innovative materials and technologies for energy harvesting applications, mainly investigating novel systems for dye-sensitized solar cells and water splitting devices. 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Software quality has been a major issue in software development history. The ultimate aim is to ensure user satisfaction with the reliability and operation of software products based on well-defined characteristics. Several software quality models have been produced, such as the procedural model [1], the object-oriented model [2] and the international standard quality model established by ISO and IEC [3].
\nTo evaluate the software agent, published works have been investigated in relation to measures to evaluate it, which mainly consider the adoption of measures of other paradigms, such as procedural and object-oriented, since there are programming characteristics in common with software oriented to agents, such as modular programming and encapsulation [4, 5].
\nWe are interested in applying the software quality model for another type of software: agent systems. We take the viewpoint that it is essential to analyze the key software agent characteristics in order to evaluate the quality of a software agent. These characteristics define agent behavior inside a multi-agent system and include social ability, autonomy, proactivity, reactivity, adaptability, intelligence and mobility [6, 7].
\nIn this chapter, we present the study of the characteristics of social ability, autonomy and proactivity, with their attributes and associated measures, considering that they are the most representative of the software agent [8, 9, 10]. The objective of this research work is to propose attributes associated with these characteristics of the software agent and a set of measures that allow evaluating these attributes [11].
\nTo evaluate the quality of software, ISO/IEC proposed in 2001 to decompose this quality into three hierarchical levels: characteristics (correspond to properties that the software must verify), sub-characteristics or attributes (they are measurable qualities that influence each characteristic) and measurements (are the metrics that allow evaluating the attributes) [3]. Based on this decomposition, this research work has been proposed to evaluate the characteristics of a software agent.
\nThe rest of the chapter is structured as follows. The characteristic of an agent is defined, and attributes related to social ability, autonomy and proactivity are presented. Then, works related to the development of measures to evaluate characteristics of the software agent are presented. Next, measures to evaluate the attributes associated with these characteristics are described, and their application to a case study is presented. The chapter ends with a series of conclusions and lines of future research.
\nAccording to McCall [1] and ISO/IEC [3], to measure the quality of a software product, three aspects of the product must be defined: its characteristics, its sub-characteristics (called attributes) and the measurements of these attributes.
\nThe characteristics considered in this work as more representative of a software agent are its social ability, autonomy and proactivity [11]. Table 1 summarizes these characteristics, providing a short definition and a list of relevant attributes that we identified in [11].
\nCharacteristics | \nDefinition | \nAttributes | \n
---|---|---|
The agent is able to interact with other agents, and possibly humans, in order to achieve its design objectives. | \n\n
| \n|
The agent is able to operate on its own without the need for any human guidance or the intervention of external elements. It has control over its own actions and internal states. | \n\n
| \n|
The agent is able to exhibit goal-directed behavior by taking the initiative in order to achieve its design objectives. This capability often requires the agent to anticipate future situations (to take the initiative), to interact with other agents and to perceive its environment. | \n\n
| \n
Characteristics and attributes of software agents.
The importance of the social ability is that in order to achieve its objectives, the agent must be able to communicate, negotiate and cooperate with the other agents of the system [6, 11].
\nThe importance of autonomy lies in the fact that in order to achieve an objective the agent must have the possibility to decide, not only how to achieve an objective, but also that the objectives must be sought on the basis of an interest generated endogenously [12], must control their internal state, have independence and the ability to adapt to the needs of their environment [10].
\nThe importance of proactivity is that it implies that the agent executes actions on his own initiative to achieve his objectives, interacting with the agents in the environment and reacting to the stimuli that appear in this environment, so he must have the ability to evaluate their environment and decide what action to take [13, 14].
\nConsidering the research developed on the characteristics and quality measures of a software agent, until before 2013, few studies in the literature had focused on proposing measures related to the characteristics of social ability, autonomy and proactivity of a software agent and few specify a set of specific measures to evaluate these characteristics.
\nIn [4], it is proposed to measure the social ability of the agent using the complexity of the agent as a way of knowing the degree of the organizational dimensions of the agent (such as social, relational, environmental and personal).
\nCernuzzi and Rossi proposed a framework for an evaluation of the analysis and design of agent-oriented modeling methods. They evaluate the autonomy of an agent considering whether or not the modeling techniques check whether the agents have control over their internal state and behavior [15].
\nIn 2004, Shin presented the results of adapting some measures of procedural and object-oriented paradigms to agent-oriented software, as well as adding specific measures for this paradigm. In his work, he does not define attributes to evaluate these characteristics; he only defines measures to assess some aspects of these characteristics of the agent’s software [16].
\nHuber proposes measuring social dependence to evaluate autonomy. To calculate a global value of the autonomy of a software agent, Huber combines the value of the autonomy of social integrity and the value of the autonomy of the dependency [17].
\nThe state of the art revealed the need to propose measures that would allow evaluating the most relevant characteristics of the software agent, with appropriate measures that consider the attributes related to these characteristics.
\nThe measures proposed for each attribute are the result of research in software agents. Some were selected from the procedural and object-oriented paradigms, and others are new measures specially designed to evaluate these attributes [11].
\nThe social ability in the agents is the competence they have at the moment of exchanging information between them (communication), the ability in the joint collaboration (cooperation) and the ability to reach an agreement on the way forward to reach their objectives (negotiation) [18].
\nThe communication attribute is identified with the agent’s ability to receive and send messages by the agent to achieve its objectives. It has been determined that a good communication of the agent can be evaluated considering: the number of messages invoked in response to a message received by the agent (RFM), the size of the messages sent by the agent during execution (AMS), and the number of incoming and outgoing messages received (FIM) and sent (FOM) by the agent to maintain a significant communication link or perform some objectives [16, 18].
\nThe cooperation attribute is identified with the agent’s ability to respond to the services requested by other agents and offer services to other agents. It has been determined that good cooperation can be evaluated considering: the agent’s ability to accept or reject services requested by other agents (SRRA), and the agent’s ability to offer services (ASA) [6, 18].
\nThe negotiation attribute is identified with the agent’s ability to establish commitments, resolve conflicts and reach agreements with other agents to ensure compliance with its objectives. Therefore, this attribute can be evaluated considering: the number of objectives achieved (AGA), the number of messages sent by the agent when another agent requires a service from it (MRS), and the number of messages sent by the agent when requesting a service from other agents (MSS) [6, 18]. Table 2 presents the nine proposed measures for evaluating a software agent’s social ability and its definitions.
\nMeasures to evaluate the attributes of social ability | \n||
---|---|---|
Answers by message | \nRFM: Measures the number of messages that are sent in response to a message received by the agent | \n|
Average message size | \nAMS: Measures the data size of the messages sent by the agent in their communication | \n|
Number of messagesreceived | \nFIM: Measures the number of messages received in the agent’s communication during its lifetime | \n|
Number of messages sent | \nFOM: Measures the number of messages sent by the agent in the agent’s communication during its execution time | \n|
Service requests rejected by the Agent | \nSRRA: Measures the percentage of services rejected by the agent when other agents require their services | \n|
Amount of services offered by the agent | \nASA: Measures the amount of services that the agent advertises in the yellow pages directory of their environment | \n|
Objectives achieved by the agent | \nAGA: Measures the efficiency of agent negotiation to achieve its objectives, with the support of other agents in the environment | \n|
Messages for a requested service | \nMRS: Measures the number of messages exchanged by the agent when conducting a negotiation, when another agent is requesting their services | \n|
Messages sent to request a service | \nMSS: Measures the number of messages exchanged by the agent when performing a negotiation when the agent requests a service from another agent | \n
Measures to evaluate the attributes of social ability.
Autonomy in agents is understood as the agent’s ability to control his own actions (self-control), the ability to manage his behavior and other information related to his actions (functional independence) and the ability to self-adjust and adapt to new requirements (capacity for evolution) [13].
\nThe self-control attribute is identified with the fact that the agent is able to operate on its own, without the need for human support or the intervention of external elements, to achieve its objectives [13], and with the level of control that the agent has about its own state and behavior [4]. It has been determined that a good self-control of the agent can be evaluated considering: the amount and complexity of the pointers or references that the agent uses in its programming in the agent’s internal state (SC), the size of the agent’s internal state (ISS), and the complexity of the services that the agent offers (BC) [13].
\nThe functional independence attribute is identified with the executive tasks that require an action that the agent must perform on behalf of any of the users it represents or of other agents [6, 16]. A good level of functional independence indicates that the agent does not have to perform many executive tasks, which can be evaluated considering the fraction of messages requiring action by the user or other agents of the system with respect to all messages received [13]. It has been determined that a good functional independence of the agent can be evaluated considering the influence on the agent of the fraction of executive messages (that request an action) received from the user, to whom the agent represents, or from other agents (to whom it is obligated to respond) with respect to all received messages (EMR) [13].
\nThe attribute capacity of evolution is identified with the agent’s ability to adapt to the needs of the environment [19] and take the necessary measures to self-adjust to new objectives [20]. A good capacity for evolution can be evaluated considering: the ability to update its status by the agent (SUC), and the frequency of updating its status (FSU) [13]. Table 3 presents the six measures proposed to evaluate the agent’s autonomy and its definitions.
\nMeasures to evaluate the attributes of autonomy | \n||
---|---|---|
Structural complexity | \nSC: Measures the amount and complexity of the pointers or references that the agent uses in its programming in the agent’s internal state | \n|
Size of the internal state | \nISS: Measures the size of the agent’s internal state | \n|
Behavior complexity | \nBC: Measures the complexity of the services that the agent offers (only applies to agents that offer services) | \n|
Fraction of executive type messages | \nEMR: Measures the influence on the agent of the fraction of executive messages (that request an action) received from the user, to whom the agent represents, or from other agents (to whom it is obligated to respond) with respect to all received messages (considering communication actions) | \n|
Capacity to update the status | \nSUC: Measures the agent’s capacity to update its status | \n|
Status update frequency | \nFSU: Measures the update frequency of the agent’s state during execution | \n
Measures to evaluate the attributes of autonomy.
Proactivity refers to the ability of agents to achieve their goals. To do this, it must make decisions dynamically (initiative), have the ability to relate to obtain information that helps solve problems (interaction) and must act actively in response to environmental stimuli (reaction) [10].
\nThe initiative attribute is identified with the agent’s capacity to meet the objectives defined in its design, through goal-directed behavior [6], and to undertake an action on its own with the goal of achieving its objectives [10, 21]. A good initiative capacity can be evaluated considering: the number of roles that the agent must develop (NOR), the number of objectives reached by the agent (AGA), and the average number of messages exchanged by the agent to achieve its objectives (MAG) [10].
\nThe interaction attribute is identified with the agent’s capacity to interact with other agents and their environment [10, 22]. A good interaction capacity can be evaluated considering: the number of services implemented within the agent that enable it to achieve its goals (SA), the number of different types of agent messages that the agent can process (NMT) and the average number of public services called per agent (NSC) [10].
\nThe reaction attribute is identified with the agent’s capacity to react to a stimulus from the environment according to a stimulus/response behavior [23]. It has been determined that a good capacity for reaction can be evaluated considering: the number of requests received and resolved at runtime (NPR), and the agent’s operation complexity (AOC) [10]. Table 4 presents the eight proposed measures to evaluate the proactivity of a software agent and their definitions.
\nMeasures to evaluate the attributes of proactivity | \n||
---|---|---|
Number of roles | \nNOR: Measures the influence on initiative by the number of roles assigned to an agent in the system under evaluation and defined in the design phase | \n|
Number of goals | \nAGA: Measures the relationship between the number of goals achieved by the agent during execution over the originally assigned goals | \n|
Messages to achieve goals | \nMAG: Measures the number of executive messages used to communicate with other system agents to achieve its goals | \n|
Services per agent | \nSA: Measures the number of services implemented within the agent (number of implemented public methods or offered services, not including internal methods) that enable it to achieve its goals | \n|
Number of message types | \nNMT: Measures the number of different types of agent messages that the agent can process | \n|
Number of services called per agent | \nNSC: Measures the average number of public services called per agent | \n|
Number of processed requests | \nNPR: Measures the number of requests received and resolved at runtime | \n|
Agent operations complexity | \nAOC: Measures the mean complexity of the operations to be performed by the agent to achieve its goals | \n
Measures to evaluate the attributes of proactivity.
Figure 1 shows a summary of the characteristics, attributes and measures proposed for the software agent.
\nCharacteristics, attributes and measures of a software agent.
To use the quality measures, it is proposed to follow the following steps, which are an adaptation of those proposed in [24].
Determine the weights of the different characteristics, attributes and measures. To do this, the Hierarchical Analysis Method [25] can be used to obtain the relevant matrices adapted to the problem’s environment:
The weights of the characteristics are determined from the relevance matrix obtained through surveys to software engineers.
The weights of the attributes for each characteristic are determined, using surveys to the software engineers to determine the matrices of relevance.
The weights of each measure are determined for each attribute.
Evaluate the values of each measure:
Calculate the values of each measure according to the scope of application
Normalize the proposed measures if necessary
Based on the weights and the values of the measurements, the following are determined:
The quality values of the attributes of each characteristic
The quality values of each characteristic
The quality value associated with the software agent system
Analyze the results
Next, a case study corresponding to the agent management process of a banking environment is presented, which considers agents of the bank type, the client type and the facilitator agent, and which performs an exchange of knowledge and actions among these agents (Figure 2).
\nBank system agents.
The agents of the system are related through operations typical of a bank, such as creating an account, turning money or requesting a loan. The system consists of two agents of type clients and three agents of type bank, in addition to a facilitator agent. The first one will initiate the conversations and the banks will try to answer them by carrying out internal processes or questions to other entities of the same nature.
\nTo carry out this study, software was used that applied the evaluations of the measures of this work [26, 27].
\nThe JADE platform was used to design the software [28], and the coding was performed in the Eclipse integrated development environment [29]. Three different experiments were carried out to evaluate the different measures exposed in this work. An aspect of the graphical interface of the systems implemented for the banking system is presented in Figure 3.
\nGraphical interface of the banking multi-agent system.
In all the experiments, the opinion of several experts in the development of software oriented to agents with a score between 0 and 10 of the measures considered in the system was considered; and then the Kolmogorov-Smirnov test was applied [30], in which the arithmetic mean of the opinions of the experts and the arithmetic mean of the measures to make them comparable were considered.
\nIn the first experiment, measures were applied to evaluate the social ability of each agent in the system. Figure 4 shows the average results for each measure for each attribute and for each agent present in the system. Figure 5 presents the value of the attributes and the social ability, calculated considering the arithmetic mean of the measurements for each attribute. It is observed that the banking agents have a greater value of the cooperation attribute, while the client agents have it in the negotiation. Analyzing the values for the system, the average values of all the attributes are very similar (around 86%). Finally, the value of the social ability of the system is 86%, which is high for this system.
\nAverage values of the measures of the attributes of social ability per agent.
Average values of social ability measures per agent.
Regarding the evaluation of experts on the measures of social ability applying the Kolmogorov-Smirnov test, the arithmetic mean of the opinions of the experts and the arithmetic mean of the measurements were taken, obtaining a level of significance of 0.50 that allows to reject the hypothesis that both samples come from different distributions. Figure 6 presents a comparison of the results of the average obtained by the system and the experts, applying the Kolmogorov-Smirnov test.
\nAverage values of the experts and the system.
In the second experiment, measures were applied to evaluate the autonomy of each agent in the system. Figure 7 shows the average results for each measure for each attribute and for each agent present in the system. Figure 8 presents the value of attributes and autonomy, calculated considering the arithmetic mean of the measurements for each attribute. The attributes influence the autonomy value of each agent, being lower than those of the banking agents and a little greater than the one of the client agents because the banking agents have greater capacity of evolution and functional independence. The average autonomy is 80%.
\nAverage values of the measures of the attributes of the autonomy per agent.
Average values of autonomy measures per agent.
Figure 9 shows the comparison of the results of the average obtained by the system and the experts, applying the Kolmogorov-Smirnov test. Regarding the evaluation of experts on the measures of autonomy of the agents of the system, the arithmetic mean of the opinions of the experts and the arithmetic mean of the measures were considered, obtaining a level of significance of 0.75, which allows to reject the hypothesis that both samples come from different distributions.
\nAverage values of the experts and the system.
In the third experiment, measures were applied to evaluate the proactivity of each agent in the system. Figure 10 shows the average results for each measure for each attribute and for each agent present in the system. Figure 11 shows the value of the attributes and proactivity calculated considering the arithmetic mean of the measurements for each attribute. There are high values of initiative of the banking agents (on average it is 97%) followed by the other two attributes: interaction and reaction (95% on average). Finally, the proactivity of the system of the system is very high, with 96% on average, which is explained by the high interaction of the agents of the system.
\nAverage values of the measures of the attributes of the proactivity per agent.
Average values of proactivity measures per agent.
Figure 12 shows the comparison of the results of the average obtained by the system and the experts, applying the Kolmogorov-Smirnov test. Regarding the evaluation of experts on the measures of proactivity of the agents of the system, the arithmetic mean of the opinions of the experts and the arithmetic mean of the measures were considered, obtaining a level of significance of 0.45, which allows to reject the hypothesis that both samples come from different distributions.
\nAverage values of the experts and the system.
From the study of software agent technology, different characteristics present in this type of software were defined. Considering these characteristics, the work of studying three of them was addressed: social ability, autonomy and proactivity. These, in turn, were divided into nine attributes (three for each characteristic), to consider different factors that represent important aspects of each characteristic, susceptible to being evaluated.
\nFor these attributes, 23 measures were designed for the evaluation of these attributes, and they can be used in an agent-oriented application to obtain a consistent evaluation of the characteristics studied.
\nAn application was also developed [26, 27], making use of the Eclipse platform [29] and object orientation in Java, which allowed to implement a form of automatic evaluation of the proposed measures in this work, on different agent-oriented applications, and that shows that the measures developed are automatable. The use of this tool also provided the possibility of refining the measures to study its behavior in greater detail. In addition, the application allowed to modify the values of the weights associated with the measures to determine the most appropriate for each situation under study.
\nThis work constitutes an advance of the research carried out to reach a quality model in the agent-oriented paradigm, which allows developers to have help with which to satisfactorily evaluate their work, in order to ensure that it is appropriate for the functions for which it was produced, considering the characteristics that each component of the application must fulfill.
\nGroundwater’s chemical composition is obtained from a variety of sources of solutes, including gases and atmospheric aerosols, below-surface replacement and precipitation reactions, weathering and erosional activities of soils and rocks, and other anthropogenic effects. The study of water chemistry can reveal a lot about the geological history of rocks as well as the velocity and direction of water flow [1]. Groundwater’s chemical, physical, and bacteriological properties determine its suitability for municipal, commercial, industrial, agricultural, and domestic use [2].
To understand an aquifer’s hydrogeochemistry, a detailed understanding of the rock-water interactions that influence groundwater chemical composition is required. The mineral composition of the rock is the primary component that governs a location’s water chemistry [3]. The local regime differs from other sites due to the continual interfacial reactivity of water with rocks.
Fluoride, currently considered a pollutant in several regions of the world, is frequently related with the dissolution of fluorine-containing minerals in rocks, as well as growing anthropogenic influences [4]. Groundwater chemistry is influenced by mineral water interfacial interactions such as carbonate weathering and dissolution, silicate weathering, and ion exchange activities. Groundwater composition in shallow alluvial aquifers is controlled by hydrogeochemical processes such as dissolution, cation exchange processes, calcite equilibrium, and residence period, as well as the flow channel. The hydrogeochemical fluctuations of groundwater from a semiarid sedimentary basin are caused by salt leaching from the surface, ion exchange processes, and residence time [5].
Fluoride ion concentrations in groundwater can alter owing to chemical processes including hydration and hydrolysis, weathering and deposition, ion exchange processes, oxidation and reduction that occur during mineral-water contact [6]. These interactions influenced the mobility of dissolved constituents and altered the pH of groundwater in diverse sites. Fluoride levels were found to be excessive (10 mg/l) in several areas of Yemen [7]. The very alkaline groundwater conditions were thought to be the primary cause of fluorite disintegration.
The primary aim of this chapter is to understand the influence of geochemical processes on fluoride enrichment in groundwater in Yemen regime, as well as its relationship with other major element concentrations and health implications. The primary goal of this chapter is to review and improve understanding of the factors that influence high fluoride levels in groundwater samples.
Interactions between ground water and the minerals that make up the aquifer system control major-ion chemistry trends in the aquifer system to a large extent. Mineral dissolution and precipitation, oxidation and reduction, and ion exchange are all important geochemical reactions that can affect solute concentrations in groundwater systems. Evaporation and mixing of water from various sources are examples of additional processes that can affect solute concentrations. [8].
Natural causes such as rock-water interactions while flowing are of specific groundwater quality concerns. Fluoride is one of the most common geogenic pollutants found in groundwater [9]. More than 260 million people are thought to be impacted by elevated fluoride levels in drinking water across the world. People in more than 230 districts across 20 states in India are experiencing health problems as a result of elevated fluoride levels in groundwater [10]. Many studies have found that high fluoride concentrations in groundwater are frequently linked to longer residence times in crystalline rocks in arid-semiarid climates with abundant Na-HCO3 and low Ca, as well as alkaline pH [11].
Geographic Information System (GIS) has been used to map and evaluate groundwater quality all around the world [12, 13, 14]. Gibbs [15] used total dissolved solids (TDS) vs. Na/(Na + Ca) and TDS vs. Cl/(CI + HCO3) to identify rock-water interaction. Minerals of various rock types, such as igneous, metamorphic, and sedimentary, entirely or partially dissolve in water depending on chemical weathering resistance. Chemical weathering resistance is high to extremely high in quartz-cemented sandstone, silt, slate, shale, schist, gneiss, and quartzite. Calcite cemented sandstone, limestone, rock salt, gypsum, marble, and basalt, on the other hand, have low to moderate chemical weathering resistance. Different minerals, such as halite, pyrite, gypsum, dolomite, and calcite, demonstrate good water dissolution as a result of these interactions. Because of their low resistance, olivine, pyroxene, hornblende, and biotite dissolve in water via oxidation-reduction and hydrolysis reactions. Feldspar, quartz, and clay dissolve slowly in groundwater due to their considerable resistance to weathering. Fluorite and fluorapatite, among other minerals, are regarded possible sources of fluoride as a groundwater contaminant [16].
Fluoride in groundwater comes primarily from natural sources, with earth’s crust containing 0.32% fluoride. Weathering and dissolving of fluoride minerals are the primary controls on its concentration in groundwater, since lithology plays a vital impact in its occurrence [17]. The availability and solubility of fluoride minerals, pH, temperature, anion exchange capacity of aquifer materials, type of geological materials, residence time, porosity, structure, depth, groundwater age, and concentration of carbonates and bicarbonates in water all influence the fluoride contamination of groundwater [18].
The chemical study of groundwater provides insight into the geochemical processes that occur in that area. As previously stated, geological formations regulate water quality when they come into contact with flowing water. Several investigations have found that Na-rich, Ca-poor groundwater with an alkaline pH and high HCO−3 can mobilize fluoride from fluoride-rich rock formations, resulting in higher F concentrations in groundwater. Ionic exchange between F and hydroxyl ions in fluorite minerals such as mica, amphiboles, illite, and others may occur at higher pH levels. As a result, the alkaline composition of groundwater promotes fluoride ion desorption and hence increases solubility [19].
Fluorosis is a major public health problem spot-wise all over the world, including Yemen. Endemic fluorosis has been nearly recognized as a major public health problem in six governorates in Yemen. Since the groundwater forms a major source of drinking water in rural areas, rural populations are facing a major health problem in these governorates. Fluorosis-affected areas in various parts of the country are being discovered on a regular basis. As a result, fluorosis remains an endemic problem in Yemen. Unfortunately, proper fluoride mapping has not been carried in Yemen so as to locate areas with normal, low, or high levels of fluoride. Where, the available report prepared by the General Authority of Rural Water Projects (GARWP) about the increasing fluoride content in groundwater (Between 2000 and 2006) in districts of some governorates (Sana’a, Ibb, Dhamar, Taiz, Al-Dhala, and Raimah) considered to be the first alarming report highlighted the problem of fluoride in Yemen [7].
A systematic study and delineation of fluoride contamination from Taiz and Al-Dahla governorates have been conducted by Alamry [7].
The iso-line contour map of fluoride ion concentration was created using the chemical analyses taken from wells and springs in the selected areas. As demonstrated in Figure 1, locations with a high fluoride concentration of more than 1.5 mg/l are labeled as fluoride-contaminated (bold green color).
Iso-line contour map of fluoride ion concentration from Al-Dhala districts.
The fluoride concentrations map clearly shows that there are two significant areas with high fluoride concentrations. These two places are located in the upper portion of Wadi Tuban in the low land area, separated by the Jehaf district’s highlands plateau. The first is in the Al-Dhala Qat; abah Basin, stretching from Qarad to Qa’tabah and encompassing sections of the Al-Dhala, Qa’tabah, and Al-Husha districts. The second is located south of Al-Dhala city and stretches southwest along the Wadi Tabagyan catchment region in Al-Azerq district, which is a tributary of Wadi Tuban.
The Al-Dhala Qatabah Basin’s morphology ranges from flat plains to steep slopes and hills made up primarily of restricted volcanic rocks; sands and outwash sediments blanketed the wadi basin. The Al-Dhala Qatabah Basin is located between 1100 and 1800 meters above sea level and receives about 269 mm of rainfall per year, as well as significant recharge from nearby mountain drainage.
The delineation of fluoride contamination areas from Taiz governorate has been conducted, and the iso-line contour map of fluoride ion concentration from At Aaiziyah district and its surrounding villages is given in Figure 2.
Iso-line contour map of fluoride ion concentration from Taiz districts.
It’s clearly observed that the villages of Jabal Sabir, Hawban, Hethran, and Al- Bryehey as well as Taiz City are the most affected areas by fluoride contamination in groundwater.
Some of Sana’a governorate districts, particularly Sanhan, had the highest fluoride concentrations in their drinking water (UNICEF, 2008). The majority of Yemenis living in rural areas rely on deep well water for drinking and cooking, and many of these wells are contaminated with fluoride in concentrations ranging from 2.5 to 32 mg/l. Fluorosis, particularly skeletal fluorosis, has never been seen in Yemen before, only about 8–10 years ago since it was first reported. Clinically, it develops as a result of the high fluoride concentration in bones. Dental fluorosis, on the other hand, is not a new phenomenon in Yemen, particularly in the Taiz governorate [7].
A regional hydrogeochemical study from different Yemeni terrains indicated that water-rock interaction was most likely the primary cause of high ion concentrations in groundwater. According to geochemical modeling, the main minerals controlling the aqueous geochemistry of elevated fluoride ion contamination are calcite and fluorite. The concentration of F− in groundwater was positively correlated with the concentrations of HCO3− and Na+, indicating that groundwater with high concentrations of HCO3− and Na+ leads to the dissolution of some fluoride-rich minerals. This situation of fluoride solubility control at higher fluoride concentrations can be explained by the fact that fluoride ions in groundwater can be increased as a result of CaCO3 precipitation at high pH, which removes Ca2+ from solution and allows more fluorite to dissolve [20].
The groundwater data from different Yemeni areas reveals the chemical reactions that take place in the aquifer system. The results of the linear regression study on the relationship between F and HCO3 (total alkalinity) from published papers show a positive connection, which could be owing to the simultaneous release of hydroxyl and bicarbonate ions during the leaching and dissolution of fluoride containing minerals into groundwater. With higher levels of alkalinity, the rate of weathering and mineral leaching rises, resulting in higher fluoride ion concentrations. High amounts of fluoride are also linked to greater Na+ ion concentrations. This also favors that groundwater with high HCO3− and Na+ content is usually alkaline and has relatively high OH− content, so the OH- can replace the exchangeable F− of fluoride-bearing minerals, increasing the F- content in groundwater [20].
Fluoride is one of the few chemicals that have been proven to have harmful effects on people when consumed through drinking water. Fluoride in drinking water has beneficial effects on teeth at low concentrations, but excessive exposure to fluoride in drinking water, alone or in combination with fluoride from other sources, can cause a variety of problems. As the level and duration of exposure increase, these range from mild dental fluorosis to crippling skeletal fluorosis.
The chemical characteristics of the drinking water from the study reflect high fluoride contamination above the permissible limits of Yemeni, and WHO standers and most of them are poor whoever, their nutritional status is expected to be very poor. These factors including the high concentration of Na- and HCO3− and low concentration of Ca2+ions will increase the severity of fluorosis.
The visual observations in some selected Yemeni villages identify that there are two types of fluorosis recognized, they are:
Mottling of teeth is one of the most easily recognized symptoms from different Yemeni governorates especially Taiz and Al Dhalla. The teeth of the children in the affected areas lose their normal creamy white translucent color and become rough, opaque, and chalky white. Some of the local inhabitants indicated that their teeth have be extracted and replaced with dentures. The dental fluorosis ranges from mild to severe fluorosis. The photographs represent some of dental fluorosis from the different areas in Yemen. High percentage dental fluorosis among the children has been observed in Taiz and Al-Dhala basins (Figure 3A and B).
Figures present severe dental fluorosis (A) and moderate dental fluorosis (B) in Yemeni children in the affected area, after Alamry (2009) [
Dental fluorosis is the most common fluoride ailment identified in the afflicted areas, according to visual observations from selected villages. Fluorosis in the teeth can range from mild to severe.
In general, there is a link between fluoride in the water and the occurrence of dental fluorosis in the Taiz and Al-Dhala regions. A published research paper concluded that there is a positive relationship between fluoride in water and the occurrence of dental fluorosis in Sanhan, Taiz, and Al-Dhala regions [7].
Fluorapatite is 1000 times less soluble than hydroxyapatite, the most common mineral found in bone. The F− ion aggressively substitutes for the OH− ion, resulting in an accumulation of F− in bone tissue and skeletal fluorosis [20].
The patient often complains of a vague discomfort in the limbs and trunk early on in the development of fluorotic changes in the skeleton. Back pain and stiffness, particularly in the lumbar region, follow. Fluorosis in the teeth is frequently visible with the naked eye and is easy to detect even by laypeople. On the other hand, even with the assistance of appropriate equipment, skeletal fluorosis and nonskeletal fluorosis are difficult to diagnose. Radiography is frequently used to detect symptoms such as joint enlargements or minor bone deformations.
There are no any publications presenting the problem of the skeletal fluorosis among children in the affected Yemeni places, while I have seen children in Al-Dhalla villages showing skeletal deformation, and these cases among children could be considered as cases of skeletal fluorosis unless proved otherwise, as it is shown in Figure 4.
A group of children showing skeletal deformation from Al-Dhalla region Yemen.
The hydrogeochemical characteristics of the groundwater in the study area indicated that the volcanic and plutonic rocks are the primary sources of fluoride whoever, the food could be the secondary sources.
Fluoride intake during infancy and early childhood is mirrored in dental fluorosis patterns. In most cases, the fluoride content of drinking water is considered sufficient for determining the level of fluoride exposure in a given area. There has been evidence that fluoride uptake from other sources such as food, dust, and beverages is many times higher than that from water [21].
The percentage of children with fluorosis was found to be extremely high. Although high fluoride levels in drinking water may be to blame, various food habits (such as drinking black tea and chewing Gatof Catha edulis Forsk leaves (Khat)) indicated a high fluoride contribution to the diet. Some of the children used to chew Khat also, and the Khat is cultivated in the volcanic soil and irrigated by the high fluoride concentration water [22].
Cooking with fluoridated water raises fluoride levels significantly, particularly in dry foods such as maize flour, which absorbs a lot of water during cooking. It has been reported that the simultaneous intake of food and fluoride-containing compounds can affect fluoride availability in a positive or negative way, depending on the food type, mode of administration, and type of fluoride compound [21].
The diet consumed by the children was not balanced and lacked quality. It is composed of maize flour with milk and a few rare vegetables. Intake of milk and milk products is said to diminish the fluoride availability by 20–50% in humans. Although the area under study had children taking whole milk (boiled or fermented).
A high fluoride concentration has been reported in groundwater in tertiary volcanics, from Yemeni terrain. The major ion chemistry data from groundwater of this rock revealed that Na+ is the most predominant cationic constituent followed by Ca2+ and Mg2+, the HCO3− and SO4− are found to be the most predominant anions followed by Cl− and NO3. High fluoride ion concentration in the Yemeni groundwater appears to be caused by high alkalinity due to HCO3− ions. Na+ has a positive correlation with F−, whereas Ca2+ has a negative correlation, resulting in an equilibrium condition in groundwater. CaCO3 precipitation at high pH can increase fluoride ions in groundwater by removing Ca2+ from solution and allowing more fluorite to dissolve.
Dental fluorosis is the widely fluoride disease observed in the affected areas, whereas skeletal fluorosis is observed in some villages from Al-Dhalla region. The principal causes of fluorosis among the Yemeni population appear to be related to high fluoride concentration in drinking water and Khat chewing habits, which are cultivated in the volcanic soil and irrigated by the high fluoride concentration water.
Despite the high dental fluorosis prevalence in the affected areas, no restorative treatment is being carried out. Therefore, it is highly recommended to provide safe drinking water to fluoride-affected areas.
I would like to thank the National Water Resources Authority (NWRA) Yemen and UNDP for funding this research. Also I would like to thank the publisher and anonymous reviewers for valuable suggestions and comments that have enhanced the chapter quality.
This is a brief overview of the main steps involved in publishing with IntechOpen Compacts, Monographs and Edited Books. Once you submit your proposal you will be appointed a Author Service Manager who will be your single point of contact and lead you through all the described steps below.
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\n\nPlease complete the publishing proposal form. The completed form should serve as an overview of your future Compacts, Monograph or Edited Book. Once submitted, your publishing proposal will be sent for evaluation, and a notice of acceptance or rejection will be sent within 10 to 30 working days from the date of submission.
\n\n2. SUBMIT YOUR MANUSCRIPT
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These studies not only save human lives and test animals, but they save the time and resources to be spared on a test molecule which is a complete failure having no in vitro safety.",book:{id:"6380",slug:"cytotoxicity",title:"Cytotoxicity",fullTitle:"Cytotoxicity"},signatures:"Ildikó Bácskay, Dániel Nemes, Ferenc Fenyvesi, Judit Váradi, Gábor\nVasvári, Pálma Fehér, Miklós Vecsernyés and Zoltán Ujhelyi",authors:[{id:"215449",title:"Dr.",name:"Ildikó",middleName:null,surname:"Bácskay",slug:"ildiko-bacskay",fullName:"Ildikó Bácskay"},{id:"215453",title:"Dr.",name:"Dániel",middleName:null,surname:"Nemes",slug:"daniel-nemes",fullName:"Dániel Nemes"},{id:"215454",title:"Dr.",name:"Zoltán",middleName:null,surname:"Ujhelyi",slug:"zoltan-ujhelyi",fullName:"Zoltán Ujhelyi"},{id:"215456",title:"Dr.",name:"Ferenc",middleName:null,surname:"Fenyvesi",slug:"ferenc-fenyvesi",fullName:"Ferenc Fenyvesi"},{id:"215457",title:"Dr.",name:"Judit",middleName:null,surname:"Váradi",slug:"judit-varadi",fullName:"Judit Váradi"},{id:"215458",title:"Dr.",name:"Gábor",middleName:null,surname:"Vasvári",slug:"gabor-vasvari",fullName:"Gábor Vasvári"},{id:"215459",title:"Dr.",name:"Pálma",middleName:null,surname:"Fehér",slug:"palma-feher",fullName:"Pálma Fehér"},{id:"215460",title:"Dr.",name:"Miklós",middleName:null,surname:"Vecsernyés",slug:"miklos-vecsernyes",fullName:"Miklós Vecsernyés"}]}],mostDownloadedChaptersLast30Days:[{id:"64762",title:"Mechanism and Health Effects of Heavy Metal Toxicity in Humans",slug:"mechanism-and-health-effects-of-heavy-metal-toxicity-in-humans",totalDownloads:10237,totalCrossrefCites:100,totalDimensionsCites:229,abstract:"Several heavy metals are found naturally in the earth crust and are exploited for various industrial and economic purposes. Among these heavy metals, a few have direct or indirect impact on the human body. Some of these heavy metals such as copper, cobalt, iron, nickel, magnesium, molybdenum, chromium, selenium, manganese and zinc have functional roles which are essential for various diverse physiological and biochemical activities in the body. However, some of these heavy metals in high doses can be harmful to the body while others such as cadmium, mercury, lead, chromium, silver, and arsenic in minute quantities have delirious effects in the body causing acute and chronic toxicities in humans. The focus of this chapter is to describe the various mechanism of intoxication of some selected heavy metals in humans along with their health effects. Therefore it aims to highlight on biochemical mechanisms of heavy metal intoxication which involves binding to proteins and enzymes, altering their activity and causing damage. More so, the mechanism by which heavy metals cause neurotoxicity, generate free radical which promotes oxidative stress damaging lipids, proteins and DNA molecules and how these free radicals propagate carcinogenesis are discussed. Alongside these mechanisms, the noxious health effects of these heavy metals are discussed.",book:{id:"7111",slug:"poisoning-in-the-modern-world-new-tricks-for-an-old-dog-",title:"Poisoning in the Modern World",fullTitle:"Poisoning in the Modern World - New Tricks for an Old Dog?"},signatures:"Godwill Azeh Engwa, Paschaline Udoka Ferdinand, Friday Nweke Nwalo and Marian N. Unachukwu",authors:[{id:"241837",title:"Mr.",name:"Godwill Azeh",middleName:null,surname:"Engwa",slug:"godwill-azeh-engwa",fullName:"Godwill Azeh Engwa"},{id:"274194",title:"BSc.",name:"Paschaline Ferdinand",middleName:null,surname:"Okeke",slug:"paschaline-ferdinand-okeke",fullName:"Paschaline Ferdinand Okeke"},{id:"286975",title:"Dr.",name:"Friday",middleName:null,surname:"Nweke Nwalo",slug:"friday-nweke-nwalo",fullName:"Friday Nweke Nwalo"},{id:"286976",title:"Dr.",name:"Marian",middleName:null,surname:"Unachukwu",slug:"marian-unachukwu",fullName:"Marian Unachukwu"}]},{id:"71742",title:"Forensic Chemistry and Toxicology",slug:"forensic-chemistry-and-toxicology",totalDownloads:800,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The current chapter deals with forensic chemistry & toxicology which is completely based on the introduction and classification of poisons and their impacts on the body and the factors affecting them and detection and examination of poisons. The purpose of this chapter is to discuss their mode of action and function once they reached in the human body. The impacts of poisons are severe and even cause death if not treated properly.",book:{id:"7847",slug:"medical-toxicology",title:"Medical Toxicology",fullTitle:"Medical Toxicology"},signatures:"Amarnath Mishra",authors:[{id:"259941",title:"Dr.",name:"Amarnath",middleName:null,surname:"Mishra",slug:"amarnath-mishra",fullName:"Amarnath Mishra"}]},{id:"71771",title:"The Clinical Importance of Herb-Drug Interactions and Toxicological Risks of Plants and Herbal Products",slug:"the-clinical-importance-of-herb-drug-interactions-and-toxicological-risks-of-plants-and-herbal-produ",totalDownloads:1435,totalCrossrefCites:6,totalDimensionsCites:10,abstract:"Approximately 70% of the world’s population has been using medicinal herbs as a complementary or alternative medicine that has grown tremendously in both developed and developing countries over the past 20 years (World Health Organization Drugs Strategy 2002–2005). This increase in consumer demand for medicinal plants continues, although scientific data are rare to create safety and efficacy profiles. Its popularity is also related to easy availability, cost-effectiveness leading to better purchasing power, and various factors that perceive that they are generally safe. Herbs are often administered simultaneously with therapeutic drugs for the treatment of major ailments, and herb-drug interactions (HDIs) increase their potential. The main routes proposed for HDIs include cytochrome P450 (CYP450)-mediated inhibition or induction and transport and flow proteins. In our review, we highlighted herbal medicines used for the treatment of various diseases with pharmacokinetic, pharmacodynamic analysis and case reports together with their adverse effects and herb-drug interactions. Therefore, this review can be used as a quick reference database for physicians and healthcare professionals involved in therapy, aiming to maximize clinical outcomes by reducing the negative and toxic effects of plants along with avoiding herb-drug interactions.",book:{id:"7847",slug:"medical-toxicology",title:"Medical Toxicology",fullTitle:"Medical Toxicology"},signatures:"Cigdem Kahraman, Zekiye Ceren Arituluk and Iffet Irem Tatli Cankaya",authors:[{id:"319337",title:"Dr.",name:"Irem Tatli",middleName:null,surname:"Cankaya",slug:"irem-tatli-cankaya",fullName:"Irem Tatli Cankaya"},{id:"319339",title:"Dr.",name:"Zekiye Ceren",middleName:null,surname:"Arituluk",slug:"zekiye-ceren-arituluk",fullName:"Zekiye Ceren Arituluk"},{id:"319340",title:"Dr.",name:"Cigdem",middleName:null,surname:"Kahraman",slug:"cigdem-kahraman",fullName:"Cigdem Kahraman"}]},{id:"65306",title:"Nephrotoxic Effects of Drugs",slug:"nephrotoxic-effects-of-drugs",totalDownloads:1612,totalCrossrefCites:4,totalDimensionsCites:6,abstract:"Drug-induced nephrotoxicity is a renal dysfunction that occurs as a result of exposure to nephrotoxic drugs. It is a common problem in certain clinical situations such as underlying renal dysfunction, cardiovascular disease, diabetes, and sepsis. Drugs can cause mild to moderate nephrotoxic problems such as intrarenal obstruction, interstitial nephritis, nephrotic syndrome, acid-base and fluid-electrolyte disturbances, alteration in intraglomerular hemodynamics, inflammatory changes in renal tubular cells, tubulointerstitial disease, and renal scarring leading to acute or chronic kidney injury. Therefore, early detection of adverse effects of drugs as well as the clinical history of the patient, basic renal functions, drug-related risk factors, and nephrotoxic drug combinations must be well known in order to prevent drug-induced nephrotoxicity and progression to end-stage renal disease.",book:{id:"7111",slug:"poisoning-in-the-modern-world-new-tricks-for-an-old-dog-",title:"Poisoning in the Modern World",fullTitle:"Poisoning in the Modern World - New Tricks for an Old Dog?"},signatures:"Azade Sari",authors:[{id:"271267",title:"Dr.",name:"Azade",middleName:null,surname:"Sari",slug:"azade-sari",fullName:"Azade Sari"}]},{id:"42020",title:"Screening of Herbal Medicines for Potential Toxicities",slug:"screening-of-herbal-medicines-for-potential-toxicities",totalDownloads:7862,totalCrossrefCites:28,totalDimensionsCites:69,abstract:null,book:{id:"3408",slug:"new-insights-into-toxicity-and-drug-testing",title:"New Insights into Toxicity and Drug Testing",fullTitle:"New Insights into Toxicity and Drug Testing"},signatures:"Obidike Ifeoma and Salawu Oluwakanyinsola",authors:[{id:"142730",title:"Dr.",name:"Ifeoma",middleName:null,surname:"Ezenyi",slug:"ifeoma-ezenyi",fullName:"Ifeoma Ezenyi"}]}],onlineFirstChaptersFilter:{topicId:"1208",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"3",title:"Bacterial Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/3.jpg",isOpenForSubmission:!1,annualVolume:null,editor:null,editorTwo:null,editorThree:null},{id:"4",title:"Fungal Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",isOpenForSubmission:!0,annualVolume:11400,editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. Board Member and Chair of Mycology Group of Chinese Society of Dermatology.",institutionString:null,institution:{name:"Sichuan University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"5",title:"Parasitic Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",isOpenForSubmission:!0,annualVolume:11401,editor:{id:"67907",title:"Dr.",name:"Amidou",middleName:null,surname:"Samie",slug:"amidou-samie",fullName:"Amidou Samie",profilePictureURL:"https://mts.intechopen.com/storage/users/67907/images/system/67907.jpg",biography:"Dr. Amidou Samie is an Associate Professor of Microbiology at the University of Venda, in South Africa, where he graduated for his PhD in May 2008. He joined the Department of Microbiology the same year and has been giving lectures on topics covering parasitology, immunology, molecular biology and industrial microbiology. He is currently a rated researcher by the National Research Foundation of South Africa at category C2. He has published widely in the field of infectious diseases and has overseen several MSc’s and PhDs. His research activities mostly cover topics on infectious diseases from epidemiology to control. His particular interest lies in the study of intestinal protozoan parasites and opportunistic infections among HIV patients as well as the potential impact of childhood diarrhoea on growth and child development. He also conducts research on water-borne diseases and water quality and is involved in the evaluation of point-of-use water treatment technologies using silver and copper nanoparticles in collaboration with the University of Virginia, USA. He also studies the use of medicinal plants for the control of infectious diseases as well as antimicrobial drug resistance.",institutionString:null,institution:{name:"University of Venda",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},{id:"6",title:"Viral Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",isOpenForSubmission:!0,annualVolume:11402,editor:{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:58,paginationItems:[{id:"81961",title:"Antioxidants as an Adjuncts to Periodontal Therapy",doi:"10.5772/intechopen.105016",signatures:"Sura Dakhil Jassim and Ali Abbas Abdulkareem",slug:"antioxidants-as-an-adjuncts-to-periodontal-therapy",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Trauma",coverURL:"https://cdn.intechopen.com/books/images_new/11567.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"82357",title:"Caries Management Aided by Fluorescence-Based Devices",doi:"10.5772/intechopen.105567",signatures:"Atena Galuscan, Daniela Jumanca and Aurora Doris Fratila",slug:"caries-management-aided-by-fluorescence-based-devices",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Caries - The Selection of Restoration Methods and Restorative Materials",coverURL:"https://cdn.intechopen.com/books/images_new/11565.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"81894",title:"Diet and Nutrition and Their Relationship with Early Childhood Dental Caries",doi:"10.5772/intechopen.105123",signatures:"Luanna Gonçalves Ferreira, Giuliana de Campos Chaves Lamarque and Francisco Wanderley Garcia Paula-Silva",slug:"diet-and-nutrition-and-their-relationship-with-early-childhood-dental-caries",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Caries - The Selection of Restoration Methods and Restorative Materials",coverURL:"https://cdn.intechopen.com/books/images_new/11565.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"81595",title:"Prosthetic Concepts in Dental Implantology",doi:"10.5772/intechopen.104725",signatures:"Ivica Pelivan",slug:"prosthetic-concepts-in-dental-implantology",totalDownloads:27,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}}]},overviewPagePublishedBooks:{paginationCount:8,paginationItems:[{type:"book",id:"6668",title:"Dental Caries",subtitle:"Diagnosis, Prevention and Management",coverURL:"https://cdn.intechopen.com/books/images_new/6668.jpg",slug:"dental-caries-diagnosis-prevention-and-management",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Zühre Akarslan",hash:"b0f7667770a391f772726c3013c1b9ba",volumeInSeries:1,fullTitle:"Dental Caries - Diagnosis, Prevention and Management",editors:[{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",institutionURL:null,country:{name:"Turkey"}}}]},{type:"book",id:"7139",title:"Current Approaches in Orthodontics",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7139.jpg",slug:"current-approaches-in-orthodontics",publishedDate:"April 10th 2019",editedByType:"Edited by",bookSignature:"Belma Işık Aslan and Fatma Deniz Uzuner",hash:"2c77384eeb748cf05a898d65b9dcb48a",volumeInSeries:2,fullTitle:"Current Approaches in Orthodontics",editors:[{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. 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Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. 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Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",institutionURL:null,country:{name:"India"}}}]}]},openForSubmissionBooks:{paginationCount:3,paginationItems:[{id:"11570",title:"Influenza - New Approaches",coverURL:"https://cdn.intechopen.com/books/images_new/11570.jpg",hash:"157b379b9d7a4bf5e2cc7a742f155a44",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 10th 2022",isOpenForSubmission:!0,editors:[{id:"139889",title:"Dr.",name:"Seyyed Shamsadin",surname:"Athari",slug:"seyyed-shamsadin-athari",fullName:"Seyyed Shamsadin Athari"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11569",title:"Bacterial Sexually Transmitted Infections - New Findings, Diagnosis, Treatment, and Prevention",coverURL:"https://cdn.intechopen.com/books/images_new/11569.jpg",hash:"069d6142ecb0d46d14920102d48c0e9d",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 31st 2022",isOpenForSubmission:!0,editors:[{id:"189561",title:"Dr.",name:"Mihaela Laura",surname:"Vica",slug:"mihaela-laura-vica",fullName:"Mihaela Laura Vica"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11568",title:"Staphylococcal Infections - Recent Advances and Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/11568.jpg",hash:"92c881664d1921c7f2d0fee34b78cd08",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"July 8th 2022",isOpenForSubmission:!0,editors:[{id:"59719",title:"Dr.",name:"Jaime",surname:"Bustos-Martínez",slug:"jaime-bustos-martinez",fullName:"Jaime Bustos-Martínez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:10,paginationItems:[{id:"82380",title:"Evolution of Parasitism and Pathogenic Adaptations in Certain Medically Important Fungi",doi:"10.5772/intechopen.105206",signatures:"Gokul Shankar Sabesan, Ranjit Singh AJA, Ranjith Mehenderkar and Basanta Kumar Mohanty",slug:"evolution-of-parasitism-and-pathogenic-adaptations-in-certain-medically-important-fungi",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fungal Infectious Diseases - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11400.jpg",subseries:{id:"4",title:"Fungal Infectious Diseases"}}},{id:"82367",title:"Spatial Variation and Factors Associated with Unsuppressed HIV Viral Load among Women in an HIV Hyperendemic Area of KwaZulu-Natal, South Africa",doi:"10.5772/intechopen.105547",signatures:"Adenike O. 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He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. Voyich",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Montana State University",country:{name:"United States of America"}}},{id:"330412",title:"Dr.",name:"Muhammad",middleName:null,surname:"Farhab",slug:"muhammad-farhab",fullName:"Muhammad Farhab",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"349495",title:"Dr.",name:"Muhammad",middleName:null,surname:"Ijaz",slug:"muhammad-ijaz",fullName:"Muhammad Ijaz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}}]}},subseries:{item:{id:"95",type:"subseries",title:"Urban Planning and Environmental Management",keywords:"Circular economy, Contingency planning and response to disasters, Ecosystem services, Integrated urban water management, Nature-based solutions, Sustainable urban development, Urban green spaces",scope:"