Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\n
We wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\n
Throughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\n
We wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
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The use of dental implants has skyrocketed in the past thirty years. As the benefits of therapy became apparent, implant treatment earned a widespread acceptance. The need for dental implants has resulted in a rapid expansion of the market worldwide. To date, general dentists and a variety of specialists offer implants as a solution to partial and complete edentulism. Implant dentistry continues to advance with the development of new surgical and prosthodontic techniques. \nThe purpose of Implant Dentistry - The Most Promising Discipline of Dentistry is to present a comtemporary resource for dentists who want to replace missing teeth with dental implants. It is a text that integrates common threads among basic science, clinical experience and future concepts. This book consists of twenty-one chapters divided into four sections.",isbn:null,printIsbn:"978-953-307-481-8",pdfIsbn:"978-953-51-6508-8",doi:"10.5772/964",price:139,priceEur:155,priceUsd:179,slug:"implant-dentistry-the-most-promising-discipline-of-dentistry",numberOfPages:490,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"af264376cc47bfd447ff2a0c2cf1bdc7",bookSignature:"Ilser Turkyilmaz",publishedDate:"October 3rd 2011",coverURL:"https://cdn.intechopen.com/books/images_new/451.jpg",numberOfDownloads:148237,numberOfWosCitations:42,numberOfCrossrefCitations:31,numberOfCrossrefCitationsByBook:3,numberOfDimensionsCitations:65,numberOfDimensionsCitationsByBook:6,hasAltmetrics:0,numberOfTotalCitations:138,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 12th 2010",dateEndSecondStepPublish:"November 9th 2010",dateEndThirdStepPublish:"March 16th 2011",dateEndFourthStepPublish:"April 15th 2011",dateEndFifthStepPublish:"June 14th 2011",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"26024",title:"Prof.",name:"Ilser",middleName:null,surname:"Turkyilmaz",slug:"ilser-turkyilmaz",fullName:"Ilser Turkyilmaz",profilePictureURL:"https://mts.intechopen.com/storage/users/26024/images/1852_n.jpg",biography:"Dr. Ilser Turkyilmaz obtained his dental degree from Hacettepe University, Ankara, Turkey in 1998. Immediately after graduation, he started his PhD program in the Department of Prosthodontics, Hacettepe University. He completed that program in 2004 and kept working as an instructor in the same department. Dr. Turkyilmaz then was invited by Goteborg University, Goteborg, Sweden for research collaborations. He worked in the Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden in 2005. He returned to Hacettepe University in the end of 2005 and then worked in private practice in Ankara from February 2006 to May 2007. He was accepted for an implant prosthodontic fellowship program in the Department of Restorative and Prosthetic Dentistry, The Ohio State University, Columbus, Ohio, and worked in that university as an implant prosthodontic fellow from June 2007 to October 2008. He took up a full-time position as an assistant professor in the Department of Prosthodontics at the University of Texas Health Science Center in San Antonio, Texas, USA on November 1, 2008. Dr. Turkyilmaz maintains a private practice in the school’s faculty practice. He treats patients with esthetic and reconstructive needs using implants, veneers, crowns, fixed partial dentures, complete dentures, and partial dentures. Dr. Turkyilmaz is particularly interested in dental implant studies regarding early/immediate loading protocols, implant stability measurements using resonance frequency analysis, bone density evaluations using computerized tomography (CT), flapless implant surgeries using CT-generated surgical guides, and the biomechanical aspects of implants. He has currently 50 scientific articles published in well-known international journals. He has also given lectures including dental implants at local, national and international meetings. 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1. Introduction
\n
For the sustainable future environment, the renewable energy sources have been hailed as promising solution for primary energy supply. The rise in the global temperature can be expected to reach to an alarming level if the dependency on fossil fuels is unabated [1, 2, 3, 4, 5]. Solar energy is believed to be the only renewable energy source with highest energy potential among all energy sources, which is many time than the global energy demand [6, 7]. However, to solar energy useful energy, photovoltaic systems provide the simplest configuration to produce electricity by the direct utilization of solar radiations [8, 9, 10].
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The photovoltaic market is having a huge diversity of photovoltaic technology which is ranging from simple single junction, non-concentrating, stationary flat plate panels, to advanced, multi-junction cell based concentrated photovoltaic systems. Such diversity depicts many different system configurations with different working conditions and parameters. The third generation multi-junction solar cell (MJC) concentrated photovoltaic (CPV) system provide highly efficient photovoltaic technology, available hitherto [11]. As we know, solar energy consists of two type of radiations i.e. beam and diffuse. Concentrated photovoltaic system relies onto low cost solar concentrators which can only respond and concentrate solar beam radiations [12] onto the smaller area of solar cell, unlike flat plate PV panels which can respond to both beam and diffuse part of solar radiations. The share of beam radiations in coming energy depends upon the sky conditions and the local climate. As solar concentrators can only respond to beam radiations, therefore, the conventional CPV systems were designed as gigantic unit which huge solar tracking unit, to be installed in the open desert regions. The main reason for such desert region design and application, was due to the clear sky condition with high beam share which is ideal for CPV.
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The manufactures of PV and CPV system only furnish the catalogues of such system with rated and maximum capacity. Such rated performances are measured under controlled laboratory conditions and at certain optimum energy input. The standard testing procedure for such rated performance measurements are carried out under STC (Standard Testing Conditions, IEC 60904-3) parameters or NOCT (Nominal Operating Cell Temperature, IEC 61215 and IEC 61646) conditions [13]. Such laboratory testing conditions are totally different that the actual field operating conditions [14, 15]. The field conditions fluctuate throughout the day with different intensities. There are three factors responsible for such fluctuating field conditions. Firstly, the share of beam and diffuse radiations in the received solar energy is changing throughout the day, due to clod cover and changing sun position. Secondly, the cell operating temperature changes drastically throughout the operation due to daily and seasonal change in ambient temperature. Thirdly, the dust particles present in the air [16] and the dust storms reduce the incoming solar radiations thereby, affecting the performance output of photovoltaic modules. However, the customers and plat designers are interested in the actual output of the system which can be obtained during their filed operation and life period. Therefore, the rated performance of CPV and PV systems, available in the overwhelming catalogues of manufacturers, does not reflect the true performance of the system as the rated conditions are far different than the actual conditions [17, 18].
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In addition, every system requires different operating conditions. Therefore, despite being highly efficient photovoltaic technology, concentrated photovoltaic (CPV) are only targeted to be installed in open desert regions due to favorable conditions as due to clear sky, these regions have high beam radiation share in solar energy and CPV can only respond to beam radiations. Therefore, it can be understood that the feasibility and potential of a system cannot be judged by rated performance parameters and conditions. The real field output of the system must the real performance indicator of the system and to be used by the plant designers and the customers. Therefore, this chapter introduces the long term electrical rating as true performance parameter of Photovoltaic system. In addition, the real field performance data of CPV and conventional PV systems is also presented, for tropical weather condition, to compare and analyze the performance under different scenarios of electrical rating method.
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\n
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2. Development of CPV system
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In order to investigate the performance of the CPV system, two CPV units, one with double reflective cassegrain based concentrating assembly and other with Fresnel lens based concentrating assembly, were developed with two axis solar tracker.
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Figure 1 shows the schematic and the concentrating assembly arrangement of the two developed CPV systems for current study. The CPV unit shown in Figure 1(a), named as mini dish CPV unit, is using cassegrain arrangement of parabolic and hyperbolic reflectors, for double stage concentration. The other CPV unit, named as Fresnel lens CPV unit, as shown in Figure 1(b), is designed for single stage concentration by using Fresnel lens as solar concentrator. In both designs, the solar radiations are concentrated at the inlet of glass homogeniser, which further guides and uniformly distributes the solar radiations onto multi-junction solar cell (MJC), placed at the outlet aperture of the glass homogeniser. The back side of the MJC is attached to heat spreader and heat sink, for heat rejection, in order to keep cell temperature within the operational range. For Fresnel lens based CPV unit, the glass homogeniser is place at the focal point of the Fresnel lens. While for mini dish CPV unit, primary parabolic reflector first try to concentrate solar radiations at its focal point f1, however, due to secondary hyperbolic reflector, the solar radiations are again reflected to be focused at its focal point f2, where glass homogenizer is placed.
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Figure 1.
Developed prototypes of CPV system (a) mini dish CPV unit and (b) Fresnel lens CPV unit.
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The specifications and materials of the developed CPV prototypes are also shown in Figure 1 [12]. The concentrated light spot that can be seen at center of the glass homogenizer, verifies the perfect design of the concentrating assemblies. Both CPV modules are mounted onto the aluminum frame of two axis solar tracker, controlled by atmega128 microcontroller. The developed CPV systems have acceptance angle of 0.3–0.4° for mini dish and 0.6–0.7° for Fresnel Lens CPV unit. The control box of the two axis solar tracker, as shown in Figure 1, is based upon AVR ATmega128 microcontroller which is connected to two stepper motor drivers, power supply and GPS module. The developed two axis solar tracker works on a hybrid tracking algorithm, astronomical and optical tracking. At first, astronomical tracking is executed according to azimuth and zenith angles computed through solar geometry, as explained in [19]. For astronomical tracking to compute azimuth and zenith angles, data regarding local latitude, longitude, date and time, is received through GPS. The calculated azimuth and zenith angles are then compared with the actual position of the tracker, with reference to north or south plane and horizontal plane. If the difference is more than the required tracking accuracy i.e. 0.1° then the tracker is moved accordingly otherwise it remains stationary. The tracking algorithm and tracking path are shown in Figure 2. According to the tracking path, the solar tracker is always kept within the tracking accuracy of ±0.1°. When astronomical tracking method completes, feedback from the solar tracking sensor is obtained based upon the actual position of sun, with sensitivity of 0.1°. The solar tracking sensor consists of an array of photo-sensors and if feedback from any of the photo-sensor is high, then tracker is adjusted accordingly otherwise it remains stationary, depicting tracker is accurately facing the sun. This tracking algorithm loop then starts again from the astronomical tracking.
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Figure 2.
Hybrid tracking algorithm.
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To verify reliability and accuracy of the astronomical tracking algorithm, the calculated azimuth and zenith angles were compared with the azimuth and zenith angles data, obtained from Astronomical Applications Department of the U.S. Naval Observatory for January 1, 2015 [20] with latitude of 1.299°N and longitude of 103.771°E (for NUS EA-building). The comparison of the tracking angles is shown in Figure 3, for which calculated and obtained azimuth and zenith angle lines are overlapping. The difference in tracking angles is not more than 0.25 and 0.4 for azimuth and zenith angles respectively. This difference is within the acceptance angles of both of the CPV units and can be handled through solar tracking sensor.
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Figure 3.
Comparison of calculated and actual (a) azimuth (b) zenith angles.
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3. Testing methodology
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In order to analyze the actual field performance of the CPV system and to compare it with the conventional stationary PV, irrespective of their operating conditions, total energy output of the system for long term period of operation is taken as the common reference to compare the performance and feasibility of the photovoltaic technologies. For this purpose, an electrical rating parameter is proposed and used to demonstrate the long term performance of the photovoltaic system in terms of total energy output, expressed in kWh/m2.year. The main significance of comparison over total energy output, instead of instantaneous efficiency, is that it accommodates all of the effects of system operating condition, configuration and efficiency, and it is the main parameter of interest for the customers from any power plant. In addition, the normalization of energy output over per m2 area will help plant designers to determine the size of the plant as per required energy requirements. Furthermore, the consideration of long term performance comparison is to mitigate the effect of solar intermittency and weather condition as the average annual solar insolation and weather condition remain same. In current study, the system testing is carried out in tropical weather of Singapore, for 1 year from September, 2014 to August, 2015. Complete detail regarding the methodology of experiment and the calculation of electrical rating and its associated parameters, is discussed further in this section.
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3.1. System description
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The CPV system analysis is based upon the electrical power output, calculated from CPV current and voltage output through maximum power point tracking (MPPT). The CPV units were operated for whole day, from sun rise to sunset and the power output from the systems was recorded through Agilent data logger at an interval of 1sec. The solar energy input data of direct normal irradiance (DNI) was collected by using Pyrheliometer. The system description of current experimental setup is shown in Figure 4. To analyze the recorded data, the power output from the system and solar energy received were integrated over the whole day period by using OriginPro software, to obtain the total energy input and output of the system.
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Figure 4.
Experimental setup description of CPV system [12].
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3.2. Electrical rating
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To investigate short and long term performance of CPV system, monthly and overall electrical rating can be determined by using Eqs. (1) and (2).
where ‘n’ represent the maximum number of days, for that particular month, and ‘m’ represents the overall total number of days for which the experiment was performed and data was recorded. The parameter ‘E’ represents the daily total electrical energy output of the CPV system, given by Eq. (3). Similarly, daily total solar energy received by CPV system is given by Eq. (4).
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\n
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3.3. Daily electrical energy output and solar insolation
where ‘VCPV’ and ‘ICPV’ are voltage and current of the CPV units at maximum power point, obtained from multi-junction solar cells, AC is the area of concentrator and ‘Ir’ represents the DNI received in W/m2. The parameter ‘t’ represents the time of operation in seconds for that particular day and ‘S’ is scanning interval between two recordings, which is 1sec for current study.
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3.4. System average DNI efficiency
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Based upon the total daily energy input and output of the CPV system, daily, monthly and overall average efficiency of the system are given by Eqs. (5)–(7).
As CPV system can only accept beam radiations of solar energy, so the average efficiency mentioned above is based upon the DNI input. In order to have comparison with the conventional stationary PV system, average efficiency based upon the global horizontal irradiance (GHI) is given by Eq. (8).
In addition, CO2 emissions saving for each kWh electric produced, can also be computed by using the carbon emission factor provided by International Energy Agency (IEA) and is given by (10):
where 0.635 CO2 tons/MWhe is the value for crude oil taken from International Energy Agency (IEA) [21], for calculations in current chapter. The value of CO2 emissions saving depends upon the carbon emission factor which is different for different fuels and depends upon their calorific values.
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4. Maximum performance characteristics of systems under comparison
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In this section, the characteristics, maximum performance rating and installed location of the systems under comparison is described. Table 1 shows the maximum performance rating of the used multi-junction solar cell, by Arima Photovoltaic and Optical Co., and the developed CPV Units. The maximum efficiency of both CPV systems is based upon the real field testing at EA-Building NUS Singapore and the performance graphs with back plate or heat sink temperature, during testing, are shown in Figures 5 and 6.
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\n
Sr. no.
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Photovoltaic technology
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Performance
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1
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Multi-junction solar cell (InGaP/InGaAs/Ge)
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Concentration ratio = 500
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Efficiency = 39.5% @ 25°C cell temperature
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Efficiency = 35.2% @ 90°C cell temperature
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Concentration ratio = 100
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Efficiency = 38.5% @ 25°C cell temperature
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Efficiency = 33.6% @ 90°C cell temperature
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2
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Fresnel lens CPV unit
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Geometric concentration ratio = 476
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Maximum module efficiency = 28% Tested at NUS EA-building rooftop
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3
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Mini dish CPV unit
\n
Geometric concentration ratio = 492
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Maximum module efficiency = 18% Tested at NUS EA-building rooftop
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\n\n
Table 1.
Maximum performance rating of multi-junction solar cell and developed CPVs [12].
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Figure 5.
Mini dish CPV system performance. (a) Test 1 and (b) Test 2 [12].
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Figure 6.
Fresnel lens CPV system performance. (a) Test 1 and (b) Test 2 [12].
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It can be seen that the Maximum efficiency of Fresnel lens CPV unit is same as commercial CPV systems i.e. 28%. For both CPV prototypes, same type of multi-junction solar cell is used. However, lower conversion efficiency of mini dish CPV unit is due to aluminum reflecting coating on both reflectors, which had lower reflectance due to surface imperfections, causing lower optical efficiency of the mini dish concentrating assembly. The reason for testing the CPV efficiency at different time zones, is to show the effect of temperature on the system performance. It is evident from the Figures 5 and 6 that the CPV efficiency is decreasing with increase in the heat sink temperature in the noon time, due to higher DNI received.
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In order to show the feasibility and the potential of CPV system operation in tropical region, the performance of the CPV units is compared with the other conventional stationary PV system installed in Singapore, shown in Figure 7. The details of these PV units regarding their maximum rating, the cell type and the installed location, are given in Table 2.
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Figure 7.
Conventional monocrystalline, polycrystalline and thin film (CIS) PV systems at CITI (BCA), Singapore [22].
Performance characteristics of conventional PV systems at CITI (BCA), Singapore.
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5. Results and discussion
\n
The field operating conditions in form of daily average ambient temperature and the solar energy input as direct normal irradiance (DNI) and global horizontal irradiance (GHI), are shown in Figure 8 for the period of 1 year. The presented DNI data is the actual recorded measurements taken at the rooftop of NUS EA-building, Singapore with an interval of 1 s. The data was recorded for 1-year period from September 2014 to August 2015. The GHI and the daily average ambient temperature data were obtained from National Environment Agency (NEA) Singapore [26], for 3-year period from 2012 to 2014. However, the presented data is the 3-year average value for GHI and ambient temperature. From Figure 8, it can be seen that the longer sunshine period is observed for the month with larger amount of received solar energy. For March, the received GHI in kWh/m2/day is highest with longest sunshine period. On the other hand, for the rainy season period of November and December, the lowest amount of solar energy was received, for tropical weather of Singapore.
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Figure 8.
Monthly average values of solar irradiance (Global and DNI) and sunshine duration data per day [12].
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The field performance potential of developed CPV systems in form of monthly average DNI efficiency and monthly electrical rating, against percentage of DNI share in total received solar energy, is shown in Figure 9. At first glance, it can be seen that the monthly average electrical rating is proportional to the direct normal irradiance share. For May and June, it can be ordered that the highest electrical rating value was recorded as 297.6 and 296.2 kWh/m2.year for Fresnel Lens CPV system and 235 and 227.2 kWh/m2.year for mini dish CPV system, respectively. It’s due to larger share DNI in received solar radiations. On the other hand, for November and December, very poor output was recorded from both CPV systems due to low DNI availability. It is important to mention here that the main reason for higher electrical rating of Fresnel lens than the mini dish CPV, is due to its higher system efficiency as explained in Figure 5. The monthly average efficiencies of 22 and 16% were recorded for Fresnel lens and mini dish CPV systems, respectively. The highest efficiency was recorded for February, which is due to the longest sunshine duration and lowest ambient; the favorable conditions for CPV system.
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Figure 9.
Monthly electrical rating and monthly average efficiency of CPV systems with the DNI received [12].
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In order to compare the field performance of CPV system with conventional flat plate PV panels, in tropical urban region, the electrical rating is presented for both developed CPV systems and three PV system, based upon single junction solar cells, installed at the rooftop of CITI (BCA), Singapore [27]. The yearly performance data is shown in Figure 10. The Fresnel lens CPV system showed the highest electrical rating of 240.21 kWh/m2.year which is about 2 folds higher than the conventional PV systems. The annual average efficiency of 22% was also recorded during 1-year operation. Such long term efficiency includes all of the performance affecting parameters and that is why, it provide most meaningful and reliable performance indicating parameter for photovoltaic systems, as compared to the instantaneous rated efficiency. It is important to mention here that the CPV system showed twice the power output than the conventional PV system, indicating the superiority and feasibility of CPV technology even in tropical region, other than the open desert fields.
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Figure 10.
CPV systems and conventional PVs and their CO2 savings comparison [12].
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So far, the presented efficiency of CPV system is based upon direct normal irradiance (DNI) as solar energy input. Because concentrated photovoltaic (CPV) system can only respond to beam radiations of solar energy. This means that another big portion of solar energy in form of diffuse radiations, which is very high in tropical climates, is not considered in the efficiency calculations of CPV as solar energy input. However, conventional PV systems can respond to both, beam and diffuse radiations. Therefore, in order to compare the performance of CPV with conventional PV, diffuse radians must also be considered as solar energy input. For such scenario, based upon global horizontal irradiance, the GHI efficiency of photovoltaic systems is shown in Figure 10. An average solar insolation of 1700 kWh/m2.year is considered as global solar energy input to the photovoltaic system. The CPV system showed 14% GHI efficiency which is still 2 folds higher than conventional PV, even in tropical weather conditions. The summary of annual field performance of CPV systems is shown in Table 3. It can be seen that only 66.1% of total solar energy was received in form of beam radiations which were converted into electricity by CPV system, but still two times the power output of conventional PV. For comparison purpose, the long term energy output of conventional PV units, across the globe, is also given in Table 4.
Overall average efficiencies of conventional PV plants installed worldwide.
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Figure 11 shows the plot of monthly electrical rating against monthly received solar energy, to analyze the synergy of proposed method of electrical rating. For CPV system, monthly electrical rating is plotted against received DNI. On the other hand, the overall electrical rating of conventional PV i.e. mono crystalline, poly-crystalline and thin film, is plotted against annual average GHI of 1700 kWh/m2.year [27]. From linear regression, it can be seen that the electrical rating of photovoltaic systems is directly proportional to corresponding received solar energy i.e. DNI for the case of CPV and GHI for the case of conventional PV. In addition, it can also be seen that the slope of linear regression line gives the long term average efficiency of respected photovoltaic technology. For Fresnel lens CPV, the slope of regressed line is 0.22 which is equal to the long term average efficiency of 22%, given in Table 3. The significance of Figure 11 in the design of photovoltaic system, is that if the total DNI or GHI availability of particular region is known then the actual output of the system can be roughly estimated to have quick production potential of system in form of its electrical rating. Higher the value of solar energy input, higher the electrical rating of the system. However, for such field production estimation, only average efficiency of the system must be considered, instead of rated maximum efficiency. For desert region of Saudi Arabia, with GHI availability of 2300 kWh/m2.year [35] and assuming 90% share of beam radiations, overall output of 476 kWh/m2.year and 184 kWh/m2.year can be expected to be received from the operation of CPV and PV system, respectively, with average system efficiencies of 23 and 8%.
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Figure 11.
Total power delivered by assorted PV Systems against DNI and global irradiance [12].
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\n
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6. Summary of the chapter
\n
The long-term electrical rating of two in-house built CPV units i.e. the mini dish and the Fresnel lens CPVs, has been successfully analyzed under the outdoor tropical weather of Singapore, which is the first ever CPV performance reporting in this region. Based on the local tropical climate conditions, the mini-dish and the Fresnel lens CPVs achieved electric ratings of 178.0 and 240.2 kWh/m2.year, which is about two folds higher than the conventional PVs (mono-crystalline, poly-crystalline and thin CIS films) of 118 ± 10 kWh/m2.year, operating under the same tropical weather conditions, with only 66.1% DNI share. In addition, the average system efficiency based on the total energy input and output, for long term operation, is recommended over instantaneous maximum efficiency, as the true field performance indicator, accommodating all performance affecting parameters. The CPV system showed long term average efficiency of 22 ± 0.5% in the tropical climate, with maximum efficiency of 28%. The plot of electric rating (in kWh/m2.year) versus the annual insolation is also suggested as its slope gives the long term average efficiency, which can be used to estimate the CPV field performance against the available solar energy (DNI). To conclude, this study demonstrates a strong potential and feasibility of CPV system operation in the tropical weather conditions. It is also emphasized that the electrical rating parameter is more accurate and reliable when conducting a performance evaluation of photovoltaic systems.
\n
\n\n',keywords:"electrical rating, CPV, concentrated photovoltaic, long term performance, solar tracker, MJC",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/62179.pdf",chapterXML:"https://mts.intechopen.com/source/xml/62179.xml",downloadPdfUrl:"/chapter/pdf-download/62179",previewPdfUrl:"/chapter/pdf-preview/62179",totalDownloads:1042,totalViews:95,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:40,impactScoreQuartile:2,hasAltmetrics:0,dateSubmitted:"March 9th 2018",dateReviewed:"May 20th 2018",datePrePublished:"November 5th 2018",datePublished:"January 16th 2019",dateFinished:"June 19th 2018",readingETA:"0",abstract:"Owing to diverse photovoltaic technology and dynamic nature of meteorological data, a number of factors affect the performance of photovoltaic systems. The highly efficient concentrated photovoltaic (CPV) system can only respond to beam radiations of solar energy, unlike stationary silicon-based conventional photovoltaic (PV) panels. The availability of solar energy, and share of beam/diffuse radiations, varies from region to region, depending upon weather conditions. However, the rated performance as instantaneous maximum efficiency at STC (standard testing conditions) or NOCT (nominal operating cell temperature) in the laboratory, does not depict the true system performance under changing field conditions. The energy planners are interested in actual field performance, in terms of total delivered energy. Therefore, despite highest efficiency, CPV installations seem to be limited to desert regions, with high beam radiations availability and favorable working conditions. In this chapter, the performance potential and feasibility of CPV system is reported for long term operation in tropical weather conditions, in terms of proposed electrical rating parameter, giving total energy delivered as kWh/m2.year. From 1-year field operation of two in-house built CPV units, electrical rating of 240.2 kWh/m2.year is recorded for CPV operation in Singapore, the first ever reported CPV performance in this region, which is two folds higher than the stationary PV.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/62179",risUrl:"/chapter/ris/62179",book:{id:"6866",slug:"energy-conversion-current-technologies-and-future-trends"},signatures:"Muhammad Burhan, Muhammad Wakil Shahzad and Ng Kim\nChoon",authors:[{id:"174208",title:"Dr.",name:"Muhammad Wakil",middleName:null,surname:"Shahzad",fullName:"Muhammad Wakil Shahzad",slug:"muhammad-wakil-shahzad",email:"muhammad.w.shahzad@northumbria.ac.uk",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/174208/images/system/174208.jpg",institution:{name:"Northumbria University",institutionURL:null,country:{name:"United Kingdom"}}},{id:"249811",title:"Dr.",name:"Muhammad",middleName:null,surname:"Burhan",fullName:"Muhammad Burhan",slug:"muhammad-burhan",email:"muhammad.burhan@kaust.edu.sa",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"254696",title:"Prof.",name:"Kim Choon",middleName:null,surname:"Ng",fullName:"Kim Choon Ng",slug:"kim-choon-ng",email:"kimchoon.ng@kaust.edu.sa",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Development of CPV system",level:"1"},{id:"sec_3",title:"3. Testing methodology",level:"1"},{id:"sec_3_2",title:"3.1. System description",level:"2"},{id:"sec_4_2",title:"3.2. Electrical rating",level:"2"},{id:"sec_5_2",title:"3.3. Daily electrical energy output and solar insolation",level:"2"},{id:"sec_6_2",title:"3.4. System average DNI efficiency",level:"2"},{id:"sec_7_2",title:"3.5. System average GHI efficiency",level:"2"},{id:"sec_8_2",title:"3.6. Percentage share of beam radiations",level:"2"},{id:"sec_9_2",title:"3.7. CO2 emissions saving",level:"2"},{id:"sec_11",title:"4. Maximum performance characteristics of systems under comparison",level:"1"},{id:"sec_12",title:"5. Results and discussion",level:"1"},{id:"sec_13",title:"6. Summary of the chapter",level:"1"}],chapterReferences:[{id:"B1",body:'Shafiei E, Davidsdottir B, Leaver J, Stefansson H, Asgeirsson EI. Comparative analysis of hydrogen, biofuels and electricity transitional pathways to sustainable transport in a renewable-based energy system. Energy. 2015;83:614-627\n'},{id:"B2",body:'Burhan M, Shahzad MW, Ng KC. Development of performance model and optimization strategy for standalone operation of CPV-hydrogen system utilizing multi-junction solar cell. International Journal of Hydrogen Energy. 2017;42(43):26789-26803\n'},{id:"B3",body:'Burhan M, Chua KJE, Ng KC. Electrical rating of concentrated photovoltaic (CPV) systems: Long-term performance analysis and comparison to conventional PV systems. International Journal of Technology. 2016;7(2):189-196. DOI: 10.14716/ijtech.v7i2.2983\n'},{id:"B4",body:'Ng KC, Burhan M, Shahzad MW, Ismail ABA. Universal isotherm model to capture adsorption uptake and energy distribution of porous heterogeneous surface. Scientific Reports. 2017;7(1):10634\n'},{id:"B5",body:'Burhan M, Chua KJE, Ng KC. 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Applied energy. 2017;194:255-66\n'},{id:"B9",body:'Burhan M, Oh SJ, Chua KJE, Ng KC. Double lens collimator solar feedback sensor and master slave configuration: Development of compact and low cost two axis solar tracking system for CPV applications. Solar Energy. 2016;137:352-363\n'},{id:"B10",body:'Burhan M, Chua KJE, Ng KC. Long term hydrogen production potential of concentrated photovoltaic (CPV) system in tropical weather of Singapore. International Journal of Hydrogen Energy. 2016;41(38):16729-16742\n'},{id:"B11",body:'Burhan M, Shahzad MW, Choon NK. Hydrogen at the rooftop: Compact CPV-hydrogen system to convert sunlight to hydrogen. Applied Thermal Engineering. 2018;132:154-164\n'},{id:"B12",body:'Burhan M, Shahzad MW, Ng KC. Long-term performance potential of concentrated photovoltaic (CPV) systems. Energy Conversion and Management. 2017;148:90-99\n'},{id:"B13",body:'Arndt R, Puto IR. Basic Understanding of IEC Standard Testing for Photovoltaic Panels. 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Water Desalination and Reuse Centre, King Abdullah University of Science and Technology, Saudi Arabia
Water Desalination and Reuse Centre, King Abdullah University of Science and Technology, Saudi Arabia
'},{corresp:null,contributorFullName:"Ng Kim Choon",address:null,affiliation:'
Water Desalination and Reuse Centre, King Abdullah University of Science and Technology, Saudi Arabia
'}],corrections:null},book:{id:"6866",type:"book",title:"Energy Conversion",subtitle:"Current Technologies and Future Trends",fullTitle:"Energy Conversion - Current Technologies and Future Trends",slug:"energy-conversion-current-technologies-and-future-trends",publishedDate:"January 16th 2019",bookSignature:"Ibrahim H. Al-Bahadly",coverURL:"https://cdn.intechopen.com/books/images_new/6866.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-78984-905-9",printIsbn:"978-1-78984-904-2",pdfIsbn:"978-1-83881-739-8",reviewType:"peer-reviewed",numberOfWosCitations:25,isAvailableForWebshopOrdering:!0,editors:[{id:"19588",title:"Dr.",name:"Ibrahim H.",middleName:null,surname:"Al-Bahadly",slug:"ibrahim-h.-al-bahadly",fullName:"Ibrahim H. 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Systems",slug:"electrical-rating-long-term-performance-potential-of-photovoltaic-systems",totalDownloads:1042,totalCrossrefCites:0,signatures:"Muhammad Burhan, Muhammad Wakil Shahzad and Ng Kim\nChoon",reviewType:"peer-reviewed",authors:[{id:"174208",title:"Dr.",name:"Muhammad Wakil",middleName:null,surname:"Shahzad",fullName:"Muhammad Wakil Shahzad",slug:"muhammad-wakil-shahzad"},{id:"249811",title:"Dr.",name:"Muhammad",middleName:null,surname:"Burhan",fullName:"Muhammad Burhan",slug:"muhammad-burhan"},{id:"254696",title:"Prof.",name:"Kim Choon",middleName:null,surname:"Ng",fullName:"Kim Choon Ng",slug:"kim-choon-ng"}]},{id:"63159",type:"chapter",title:"Solar Cooling Technologies",slug:"solar-cooling-technologies",totalDownloads:2149,totalCrossrefCites:1,signatures:"Salman Ajib and Ali Alahmer",reviewType:"peer-reviewed",authors:[{id:"247163",title:"Prof.",name:"Salman",middleName:null,surname:"Ajib",fullName:"Salman 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1. Introduction
In recent years, technological advances in the field of echocardiography have allowed for a faster acquisition of images with an improved spatial and temporal resolution. As part of these advances, the advent of speckle tracking imaging has resulted in an explosion of investigations into myocardial deformation, as evidenced by more than 5000 articles on PubMed, increasing exponentially since 2005 (https://pubmed.ncbi.nlm.nih.gov/?term=speckle+tracking, accessed 7th of May 2020). The past two decades has also seen in a shift in “stress echocardiography” from being dominated by acute drug-based interventions to primarily exercise challenges. Therefore, this chapter focuses on the current knowledge related to myocardial deformation during acute exercise stress. Instead of just summarizing the current literature, a careful selection of articles is presented that is then used to provide the reader with a narrative that highlights important general principles of cardiac physiology, including the responses to exercise. To achieve this aim, first a brief overview of the principles and mechanisms governing myocardial deformation will be provided summarised and the key terminology will be defined. Then, the general role of exercise stress testing will be discussed, before the benefits of obtaining myocardial deformation during exercise in health and disease will be reviewed.
2. Principles of myocardial deformation
During contraction of the heart, deformation of the whole muscle occurs in four quantifiable dimensions. In general, these have been identified as: longitudinal shortening (=longitudinal strain, %), circumferential shortening (circumferential strain, %), radial lengthening (=radial strain, %) and rotation (apical − basal rotation = net twist angle, degrees), as well as the diastolic reversal of all of these indices. In addition, the rate of systolic shortening and diastolic lengthening can be measured, which is referred to as strain rate, twisting rate, and untwisting rate. An important distinction must be made between myocardial deformation and pure “velocities”, which do not consider the relative shortening (contraction) or lengthening (relaxation) of heart muscle itself but only consider the linear displacement of single myocardial points. Although myocardial velocities can also be measured, they are not representative of the contraction and relaxation of heart muscle. For these reasons, parameters such as E’ (“E prime”), which typically represent myocardial velocities in a single location on the mitral annulus, are not discussed in this chapter.
The conventional categorizations of deformation into strain and twist are logical from a biophysics and bioengineering perspective, since deformation of the heart can indeed be detected in these distinct 2-dimensional echocardiographic imaging planes. However, as will be reviewed in the following section on the anatomy and electrical conductance, the structure of the heart is far from symmetrical and—to achieve the final coordination of all components with each heartbeat—important functional differences in the various regions within the heart are present. These intricate deformational patterns can be conceptually simplified by considering the region-specific deformation in a 2-dimensional plane, allowing for easier evaluation of cardiac mechanics in both the laboratory and the clinic. However, one must consider the 3D deformation of the heart muscle, where the deformation of the four imaging planes occur simultaneously and with many of these aspects anatomically and functionally interwoven. This anatomical complexity is the focus of the next section.
2.1 Anatomy
Historical reviews have often credited Leonardo da Vinci’s observations in the 15th century as some of the first to describe the gross anatomy of the heart and his speculations about the resulting function. In his drawings1, da Vinci refers to the importance of vortices, which necessitate the presence of helical structures and/or motions that were apparent as “clockwise and counterclockwise spirals within the aorta as the outlet of the left ventricle” [1]. More than a century after da Vinci’s death, William Harvey published his seminal book Exercitatio Anatomica De Motu Cordis Et Sanguinis In Animalibus (An Anatomical Study on the Motion of the Heart and Blood in Living Beings, 1628 [2]), in which he established the circulation—including the anatomy and motion of the heart—as we mostly know it today, thereby also popularizing the previous work by Ibn al-Nafis [3]. In 1669, Richard Lower provided remarkable detail on the anatomy of the heart in his publication of Tractatus de Corde… (Treatise on the Heart. … [4]). Despite these early discoveries, it wasn’t until the contributions by McCallum and then Mall in the early twentieth century that there were new advancements in this field [5, 6]. During the second World War, Robb & Robb provided an exceptionally detailed overview of the accumulated knowledge that covered five centuries of discoveries [7]. Then, 27 years later, in 1969, Streeter et al. published the much-cited myocardial fiber distribution of the left ventricle (LV) in dogs, and Greenbaum et al. confirmed the observations in human cadavers [8, 9].
Today, after centuries of observations, there is still debate on the exact origins and arrangements of the heart [10]. However, general consensus exists that the mammalian LV consists of oblique fibers in the endocardium that gradually change into circumferential fibers in the midwall and continue to oblique fibers in the subepicardium, orientated in the opposite direction to those in the endocardium, thus creating what is often referred to as a helical arrangement [11, 12, 13, 14]. Noteworthy insight has also been provided by the description of sheets and laminae, which may not only impact the effect of individual myofibres but also the electrical propagation across the myocardium [15, 16]. With regard to the latter, the coordinated sequence of electrical propagation and activation of the LV occurs in a specific apex-to-base and endocardial-to-epicardial order during systole [17]. Due to these different electrical activation times, each part of the heart muscle is activated for different durations, therefore shortening and lengthening velocities (or systolic and diastolic “strain rates”) vary significantly in the different regions of the LV and are not associated with the overall heart rate [18]. A significant addition to the longstanding knowledge on oblique and circumferential fibers was provided by Lunkenheimer et al., who provided evidence for the existence of transmural myofibres that may be of fundamental relevance to the regulation of forces associated with normal myocardial contraction and relaxation [19]. Finally, there is important structural diversity on the myocyte level that contributes to the overall elasticity of the cardiomyocyte, as revealed by different isoforms of the giant protein titin, which may influence myocardial deformation in systole and diastole, not least during exercise [20, 21]. Collectively, the current knowledge indicates a non-uniform, complex mesh of diverse cardiac myofibre arrangements which may be grouped in sheets and laminae, influencing the electrical activation sequence of the heterogeneously distributed autonomic nerves in the heart (Figure 1, [22]). In comparison to the LV, the macro-structure of the right ventricle (RV) is not cone-shaped but resembles that of a crescent, almost wrapping around the LV. Yet, the underlying micro-structure is similar to the LV, albeit with some key differences. Like the LV, the epicardial and endocardial fibers are arranged helically, but with a smaller range of oblique angles [23]. The main difference to the LV seems to be in the myofiber arrangement of the midwall. Here, “the circumferentially arranged middle fibres are confined to the LV and septum” [8] and “without such beneficial architectural remodeling […] seem unsuited structurally to sustain a permanent increase in afterload” [23]. It is probably because of the overall crescent shape (that makes echocardiographic image acquisition in any plane other than the longitudinal challenging), and the lack of an obvious torsional motion, that the assessment of right ventricular deformation has largely focused on longitudinal strain.
Figure 1.
LV anatomy, strain and twist. (A) Although the detailed anatomy of the heart is still a matter of debate, the most comprehensive, evidence-based model includes a mesh of oblique, circumferential and transmural fibers (1–5). (B) LV strain is typically assessed in three planes, the longitudinal plane (from the apex to the base, L), the circumferential plane, C, and the radial plane (from the endocardium to epicardium, R). Owing to the specific anatomy, contraction of the LV results in a twisting motion around the long-axis, with an opposing rotational movement at the base compared with the apex that is rapidly released in diastole. Resultant twist and twist velocity curves produce a clear signal for peak LV twist and early diastolic untwisting rate (red arrows). Please see further details and the original figures in Refs. [14, 24].
2.2 Definitions and selection of myocardial deformation parameters
Because of the increasing number of studies focused on myocardial deformation mentioned in the introduction to this chapter, it has been inevitable that some inconsistencies exist regarding the nomenclature in the literature (Table 1). Here, a summary of the most common definitions is provided and the reader is also referred to previous review articles for further details on the terminology [24, 25, 26].
Parameter (unit)
Description
Circumferential strain (%)
Percentage shortening of the circumference
Global longitudinal strain (%)
Typically, the average strain of multiple walls obtained from different echocardiographic windows (4-chamber, 2-chamber, 3-chamber)
Longitudinal strain (%)
Shortening along the long-axis of the ventricles in a single 2-dimensional imaging plane (for example a 4-chamber view)
Shear strain
The strain resulting from two different normal strains, for example “longitudinal-circumferential shear strain”
Strain (rate) imaging
Generic term that can refer to strain data obtained with either tissue Doppler or speckle tracking echocardiography
Strain rate (/s)
The rate of shortening (strain) or lengthening (strain) of each strain
Tissue Doppler strain (%)
Strain obtained with tissue Doppler echocardiography, which is more angle-dependent than speckle tracking echocardiography
Tissue velocity imaging (%)
Echocardiographic imaging based upon Doppler modality, often synonymous with tissue Doppler strain
Twist (degrees)
Also called the net twist angle, obtained from the net difference in rotation between the left ventricular base and apex. Not to be confused with torsion or rotation, the latter referring to the local angular deformation at the base and apex
Untwisting rate (°/s)
The maximal early diastolic rate of reversal of twist
Table 1.
Deformation parameters.
With regard to the LV, three strain components have been established: longitudinal, circumferential and radial strain [25]. Systolic strain rate was once thought to reflect contractility; however, these hopes have not been sustained. Furthermore, the anatomy of the heart does not support the measurement of radial strain since there are no radial fibers in the LV or RV. Although the transmural fibers may somewhat relate to this type of strain, they maximally constitute ~20% to overall deformation and do not seem to run strictly in the radial direction. Second, the classification of twist or torsion as a “shear strain” or fourth dimension of deformation does not fit the underlying anatomy of the heart either. There is currently no empirical evidence for the existence of a meaningful number of longitudinal fibers that could determine longitudinal deformation of the ventricles. Instead, the oblique fibers that make up most of the fibers within the left ventricular walls are likely responsible for deformation in the longitudinal direction. Consequently, it does not seem appropriate to calculate twist or torsion from the longitudinal and circumferential shear angle, also because this approach does not capture the potential regional differences that exist between the base and apex in both the LV and RV. Despite these drawbacks to the radial and longitudinal parameters, it must be acknowledged that longitudinal strain has become the most established measure as a clinical marker with diagnostic potential [27]. For these reasons, in the context of this chapter, it seems appropriate to ignore LV radial strain but include LV longitudinal and circumferential strain as well as twist and untwisting rate. Since no clear circumferential fibers or twisting motion have been detected in the RV, the focus for that chamber will be exclusively on longitudinal strainFigure 2.
Figure 2.
RV strain. The measurement of RV strain at rest (left) and during exercise (right) in a patient with hypertrophic cardiomyopathy. Because of the anatomical arrangement of the RV, longitudinal strain is the most commonly investigated parameter, although further clarity is required whether to always include or exclude the septum [28]. From a functional perspective, there is strong evidence that the septal deformation is more similar to that of the LV than the RV free wall, as supported by evidence of a shared morphology [29, 30]. Please see further details and the original figure in: Wu et al. [31].
3. Echocardiographic assessment of myocardial deformation during exercise
3.1 Why exercise?
Even if all humans were elite athletes, we would spend most of the time in a day in a biological state of rest—or certainly in a state of low physical activity that only constitutes a fraction of the total capacity of our cardiovascular system. Accordingly, the routine clinical practice of examining cardiac function at rest is a good representation of the condition we find ourselves in most of the time. However, when a person requires an echocardiographic examination, it is typically for clinical reasons initiated by the presence of negative symptoms, often presenting as “exertional dyspnea” or angina. If an echocardiographic examination then detects structural and functional abnormalities of the heart that are congruent with the individual’s symptoms, the diagnosis of heart disease is likely. However, resting assessment of cardiac function often fails to recapitulate conditions of exertional dyspnea, and thus can sometimes lead to misdiagnosis. Equally, waiting until the emergence of symptoms postpones clinical treatment. For this reason, “stress testing” has been suggested to offer the opportunity of a “window into the future”. By taking the person out of their typical state of rest or low physical activity and stressing the full range of their cardiovascular system until maximum effort, underlying abnormalities may be detected that remain otherwise unknown. Examples for the benefit of exercise testing have been presented in relation to “unmasking masked hypertension” [32, 33]. Similarly, in pregnancy it has been proposed that the cardiovascular responses to exercise tests prior to conception may be indicators of the presence or absence of complications during future pregnancies [34, 35, 36, 37]. Furthermore, the complex etiology of heart failure has justified detailed exercise testing to identify the most important contributors out of the numerous cardiac or peripheral factors that may be involved in the development and/or the state of heart failure [38, 39, 40].
It is now recognized among clinical practitioners that the investigation of myocardial deformation during exercise can provide additive value, since previous research studies have revealed new (and sometimes surprising) insight into the behavior of the heart during exercise. As will be discussed in detail in Section 3.3, these findings have informed our basic understanding of cardiac function and sometimes guided future clinical investigation. Since myocardial function, including parameters of myocardial deformation, are influenced by the general loading state of the heart, any exercise responses must be seen in the context of general cardiovascular responses, as discussed in the next section.
3.2 General cardiovascular responses to exercise
In the context of myocardial deformation, the most relevant cardiovascular and cardiopulmonary responses to a standardized exercise test pertain to stroke volume, cardiac output, end-diastolic volume, blood pressure, arterial resistance, lactate, and maximal oxygen consumption (VO2max). In healthy individuals, a clear change in these parameters can be expected at the onset of low intensity dynamic exercise that should continue to change linearly up to moderate intensities. Importantly, dynamic exercise tests cause a disproportionate peripheral vasodilation in relation to the increase in cardiac output, and hence total peripheral resistance drops sharply at the onset of exercise and then remains constant across moderate and high exercise intensities [41]. From a diastolic perspective, end-diastolic volume has been shown to increase in some studies while others have not observed any change with exercise. This is not trivial since an acute increase in end-diastolic volume has been associated with an increased stroke volume, an effect also known as the Frank-Starling mechanism [42]. However, the overall contribution of end-diastolic volume to stroke volume is still relatively low because most of the increase in stroke volume has been attributed to the enhanced contractility that reduces the end-systolic volume.
At workloads above moderate intensity, several important physiological changes occur in healthy individuals. Blood lactate concentrations increase exponentially and CO2 production rises above O2 consumption, both reflecting the greater contribution of anaerobic metabolic pathways to overall energy utilization and causing a strong stimulus for vasodilation not least in the cerebral circulation. During the highest effort, stroke volume and VO2 have been reported to plateau and even decrease, but the exact pattern and the underlying mechanisms to this response remain a matter of debate [43]. Fortunately, this does not seem to impact the interpretation of cardiovascular responses to exercise in patients, since the sub-maximal data are currently thought to be of sufficient clinical value to determine whether exercise performance is normal or impaired [44].
One important distinction between the LV and RV responses to exercise is the potential for a “disproportionate load” on the RV [45], which is perhaps explained by both a greater relative rise in pulmonary blood pressure compared with that in the aorta, and differences in RV intrinsic factors such as force development. The differences between the LV and RV responses to exercise highlight the specific impact exercise has on the cardiovascular system. Consequently, determining the true origin of exercise limitations is challenging because many components of the cardiovascular system may be affected. For example, studies have shown that an exaggerated rise in blood pressure during exercise may be associated with negative outcomes, but whether this is caused by the heart or the periphery may be more difficult to determine [46, 47, 48]. Even in heart failure, the reduced exercise tolerance has been suggested to be a result of both central and non-cardiac limitations [38, 39, 40, 49]. Consequently, assessing myocardial deformation in relation to conventional exercise responses is essential for the quantification of the contributions of the heart muscle itself.
3.3 Myocardial deformation during exercise
Whatever myocardial parameter one chooses to examine during exercise, the interpretation of the responses can be tricky. For example, an increase in myocardial deformation with sub-maximal cycle exercise along with a typical drop in arterial resistance and concomitant reductions in end-systolic volume, in the presence of no adverse structural remodeling would be reflective of a “healthy” response. Equally, it is theoretically possible that the absence of a clear increase in myocardial deformation—which could be interpreted to represent myocardial dysfunction—may be a normal response if the increase in blood pressure and peripheral resistance were excessively high (or the exercise test did in fact create a condition of increased afterload). In this case, it is conceivable that the origin of the exercise limitation may not be cardiac despite the attenuated deformation, but perhaps peripheral in nature causing an exercise failure before the cardiac reserve is fully used [39]. Therefore, this section provides an overview of the general trend of myocardial deformation during exercise, but the reader is alerted that a qualitative interpretation must be performed after consideration of the wider physiology. Articles in this section were included if the studies had obtained data with echocardiography during exercise (tissue Doppler and tissue velocity imaging data were mostly excluded because both techniques are angle-dependent and typically represent only data from a single segment within the mitral annulus). Although a promising and exciting alternative to echocardiography, myocardial deformation during exercise obtained using MRI is not the focus of this chapter [50, 51]. Studies were also excluded if they obtained data immediately following exercise effort, as discussed in more detail in the section on methodological considerations. Finally, the avid reader is referred to some excellent review articles that cover more of the literature than this book chapter can accommodate [52, 53, 54, 55].
3.3.1 Physiological insight from healthy individuals
The physiology of myocardial deformation during exercise in healthy people is the fundamental basis upon which to interpret the responses in patient populations. Although many clinical research studies also include a healthy control group, sometimes these are matched to the patient groups in their demographics and, therefore, may not represent truly “healthy” individuals. Wherever possible, the data presented here will be from populations purposefully recruited as young healthy reference groups. To date, studies have revealed a variety of new perspectives that may be of great importance for the interpretation of clinical populations.
A decade ago, two studies revealed the strain and twist responses during incremental exercise. First, Doucende et al. showed that left ventricular twist and circumferential strain increased linearly up to moderate exercise intensities, while longitudinal strain increased initially but then plateaued at low exercise efforts [56]. This study also highlighted the interdependence of systolic and diastolic deformation, the role of untwisting rate in LV filling during exercise and the contribution of the LV apex to the overall myocardial response. Second, it was shown that LV twist and untwisting rate increased linearly up to near-maximal efforts, correlating with stroke volume and, thus, perhaps contributing to maximal exercise capacity in humans [57]. The importance of regional LV deformation, at the LV apex, was again highlighted. Several other studies have revealed similar patterns of LV twist during exercise in pre- and postmenopausal women, in athletes and of humans ascending to high altitude [58, 59, 60, 61, 62]. Consequently, it is now generally accepted that an increase in LV twist with exercise up to moderate intensities can be expected as a normal response (Figure 3). Surprisingly few studies dedicated to healthy individuals have measured LV strain during exercise, but they agree in general that longitudinal strain also increases with exercise [56, 61, 62, 63, 64]. Because of the risk of potential confounders, it is not possible to directly compare the response in LV twist and strain obtained in different studies. But in general, it is of great importance to note that the patters of the responses to exercise are not always the same for the two parameters, reminding us that they do not represent the same myocardial deformation. In agreement with the general physiological response to incremental exercise, LV twist increases linearly while longitudinal strain seems to plateau at low exercise efforts. This was more recently confirmed by Williams et al., who reported the same disparity between parameters in young healthy men [62]. Interestingly, in the same study, women seemed to have more of a linear response in longitudinal strain akin to LV twist. The disparity between LV twist and longitudinal strain has also been noted in studies on aging where LV twist consistently increases, but longitudinal strain does not change or decreases. Considering the well-established progression of aortic stiffness with aging [65], longitudinal strain appears to be at odds again with general physiology. Future studies should not only examine the parameters in relation to their sensitivity as a clinical marker but also consider the fit with general physiology.
Figure 3.
Myocardial deformation to incremental exercise. LV twist curves during incremental exercise, revealing a linear increase up to 70–80% of maximal individual exercise effort for both peak systolic LV twist (highest value in black lines top row) and peak diastolic untwisting rate (lowest value within black lines bottom row). Red lines represent myocardial deformation at the LV apex, blue lines at the LV base. Black lines are the composite of apical and basal data. Please see further details and the original figure in Ref. [57].
Studying the acute effects of exercise on myocardial deformation may be influenced by the chronic remodeling that humans have experienced. In this regard, Burns et al. showed that aging seems to be associated with a reduced LV twist reserve during exercise in a population of 60-year old individuals [66]. Similarly, “female aging”, as represented by the menopause, seems to impact the myocardial response to exercise, which may be further altered by exercise training [58]. One of the more surprising observations has been that of Cooke et al. who proposed that endurance trained athletes with enlarged “athlete’s heart” and a greater stroke volume had a similar systolic LV function, including LV twist, during submaximal exercise compared to untrained humans with smaller stroke volume [67]. Similar to the results presented by Doucende and Williams discussed above [56, 62], this particular exercise response strongly suggests that the mechanical2 systolic function of the heart may not be strictly associated with its output (stroke volume). Some mathematical calculations support the potentially poor linear association between systolic LV mechanical function and ejection fraction while others suggest a strong relationship [68]. In any case, the previous findings suggest that future investigations into the interaction between systolic deformation and ejection, and diastolic deformation and filling are needed to clarify the current uncertainty. One reason for the existing disagreement between mechanical function and associated hemodynamics may be the technical limitations causing restricted views from a 2D echocardiographic window. In the case of exercise responses, this may be particularly evident at the LV apex, since the apex has been proposed as an important contributor to exercise responses (in particular in diastolic function) [56, 57, 69]. However, in the echocardiographic images relevant for the measurement of global longitudinal strain, the representation of the apical segments is proportionately small and their contribution to longitudinal strain and strain rate may be underestimated compared with short-axis views [18]. Thus, some of the insight provided by myocardial deformation during exercise in healthy people relates to our more general understanding of cardiac function.
Compared with LV strain, RV longitudinal strain seems to be ~10 percentage points higher in healthy young humans at rest, likely reflecting the different anatomy combined with a lower pulmonary resistance compared with the aorta. Most studies reporting RV strain in healthy individuals during exercise have done so by including healthy controls as comparators to cardiac patients. From those studies, some patterns have emerged that suggest a consistently increased RV longitudinal strain during submaximal exercise in healthy individuals [28, 31, 70]. The mechanisms for this are probably similar to those of the LV, where an increased sympathetic state increases contractility while peripheral (pulmonary) vasodilation decreases downstream resistance [71]. However, during intense exercise, it seems that right ventricular myocardial deformation increases perhaps less than the LV, and it has even been shown to decrease. Given that both ventricles should produce approximately the same stroke volume under stable conditions, the lower RV strain during exercise is another indicator that the interaction between the mechanical function of the ventricles and the circulation may depend as much on the local arterial resistance as it may depend on the muscular performance (and therefore health) of the ventricles, and thus fitting the long-standing concept of a greater afterload-sensitivity of the RV. Recent studies in advanced heart failure patients who were surgically implanted with left ventricular assist devices (LVAD) may support this, since the mechanical pumps “unload” the LV and shift blood volume to the rest of the circulation, maybe creating “A Different Kind of Stress Test for the RV” [72, 73]. The accurate measurement of pulmonary and aortic resistance beyond the measurement or estimation of blood pressure is certainly going to elucidate the differential exposure and performance of the two ventricles [74]. At present, it seems that exercise does indeed cause a greater afterload challenge for the RV compared with the LV. In fact, it is worth noting that the exercise modalities used in the studies presented so far in this section have mostly employed “dynamic” exercise (see Section 3.4). In this context, it is essential to point out that this type of exercise increases sympathetic activation of the myocardium and reduces arterial resistance compared with the resting state, therefore creating an environment for the LV (and at low intensities for the RV) that is characterized by reduced afterload. During higher exercise intensities, pulmonary resistance can increase during dynamic exercise and create an augmented afterload challenge [45]. Strength exercise, also called resistance exercise, and isometric handgrip exercise are two other modalities that can provide an afterload challenge for the LV [75]. Interestingly, studies employing these exercise modalities in a number of different populations have consistently shown that the reduced systolic deformation is in part compensated for by an increase in heart rate, but can also be uncoupled from diastolic function [76, 77, 78, 79]. Given that resistance exercise produces a very different challenge to dynamic exercise, and that strength training is an important addition to rehabilitation, future research should consider incorporating responses during high resistive efforts [80, 81].
3.3.2 Exercise responses in patients with cardiovascular disease
In a seminal study, Notomi et al. provided mechanistic insight into the complex interdependence between systolic and diastolic function in hypertrophic cardiomyopathy [20]. Although the study used Tissue Doppler Imaging, it is a landmark study that has provided new insight and has popularized the use of exercise testing for both basic science and new insight into cardiac performance in patients. The study revealed that LV twist during exercise was significantly reduced in patients with hypertrophic cardiomyopathy. Similarly, two other studies concluded that systolic deformation reserve is reduced in patients with hypertrophic cardiomyopathy [82, 83]. However, one challenge in patient populations is that the change in heart rate is often different compared with control groups, and therefore it is possible that the groups experienced different physiological stimuli. This is a recurring problem in exercise studies that currently reduces the confidence in some conclusions. Equally, sometimes the matching of the change in heart rate between groups may lead to unequal workloads or changes in blood pressure, highlighting again the need to interpret myocardial deformation during exercise in the context of general physiological responses. Notwithstanding, the overall trend is that LV myocardial deformation in patients is reduced in response to an acute exercise challenge, including in cardiac amyloidosis, hypertension, cancer, coronary artery disease, as well as in patients with valve disease before and after surgical correction [84, 85, 86, 87, 88, 89]. Some subtle observations, however, are worthy of discussion. For example, in patients with microvascular angina, only the subendocardial strain was reduced, and diastolic function during exercise was more severely affected than systolic reserve [90]. Similarly, myocardial regions can respond differently during exercise in coronary artery disease patients, as shown by differential basal vs. apical rotational mechanics [89]. In an elegant study in patients with hypertrophic cardiomyopathy, Soullier et al. showed that there was significant heterogeneity in the response of the different deformation parameters to exercise, and that resting twist was even increased in patients while diastolic untwisting rate was less affected [83]. In patients with a prior heart transplant, the age of the recipients and donors seem to influence the longitudinal and circumferential strain response to exercise [91, 92]. All these observations highlight the very subtle changes that can occur between parameters, and between systolic and diastolic function. To determine the full significance of such differences should be the focus of future investigations. Furthermore, it will be essential to relate myocardial deformation more often to parameters like cardiac output, to enable the meaningful interpretation of deformation indices and their contribution to the overall capacity of the heart. When this was done in previous studies, the myocardial deformation during exercise provided a clear advancement of our general understanding of the etiology and/or progression of cardiac disease [93].
Because of the prevalence and importance of pulmonary hypertension, and the exercise limitations of heart failure patients, myocardial deformation of the RV during exercise has received heightened attention [94]. Similar to the LV response, the expected increase in RV myocardial deformation during exercise is generally blunted, not just in pulmonary hypertension but also in tetralogy of Fallot, systemic sclerosis, and hypertrophic cardiomyopathy [31, 95, 96, 97]. Most often, there is clear evidence that pulmonary artery pressures increased disproportionately in the groups that had a blunted increase in RV longitudinal strain during exercise. Importantly, these patients often have normal pulmonary artery pressures at rest, which not only emphasizes the diagnostic value of exercise testing, it also highlights the possibility that patients with suspected LV pathology should be tested for the RV myocardial response to exercise.
3.4 Important practical considerations
Any echocardiographic examination consists of two main parts: (1) the acquisition of standardized echocardiographic images, and (2) the analysis of images for the quantification of relevant parameters [98, 99]. When conducting echocardiography during exercise, both parts require modified approaches to ensure that the conclusions drawn remain valid. Here, based upon our extensive practical experience, we present some “take-home-messages” that we consider essential for the echocardiographic assessment of myocardial deformation during exercises.
Typically, exercise tests are performed in a stepwise (constant intensity for some minutes, then increasing) or incremental (gradually increasing intensity with every second) manner. Because different protocols provoke different physiological responses, the correct protocol must be selected carefully.
Exercise responses depend on the relative workload of an individual. Therefore, exercise intensities should be adjusted to an individual’s anticipated capacity and patients’ myocardial deformation interpreted in relation to the relative workload [100].
The individual adjustment of workload increments during the test should also acknowledge fitness, age, sex, medical history, and acute or chronic injuries.
For the assessment of myocardial deformation during exercise, running or cycling modalities are the most common. For the reason of improved image quality and because it is relatively safe/feasible, the preferred choice for exercise echocardiography may be supine cycling.
While it is generally accepted that gentle end-expiratory breath holds can be performed to obtain images, it is preferable to obtain echocardiographic cine loops during free breathing and average some cardiac cycles during inspiration and expiration.
It is important to distinguish between the physiological demands of different exercise modalities, categorized as: dynamic, static, and impact [101]. Consequently, certain types of exercise can be considered more as an “afterload challenge” than others, and the responses of myocardial deformation may vary greatly between these types of exercise. In this context, the reader is reminded that exercise training interventions for health will need to consider the same complexities, as evidenced by the potential for differential effects of moderate continuous exercise training versus high-intensity interval training in some cardiac patients [102].
One concern with regard to exercise testing is the risk of triggering adverse events. Although this will depend on the specific individual being tested and must be decided by qualified personnel on a case-by-case basis, as evidenced by a comprehensive study performed by Rognmo et al. [103], the overall risk for serious adverse events seems to be relatively low. Particular health and safety precautions should be taken in patients with overt or suspected arrhythmia and the decision “not allowed to perform an exercise test” may have to be taken.
Standardization of echocardiographic data acquisition during exercise is absolutely necessary. Sonographers should minimize the sector width and depth, maximize imaging frame rates, only use one focal point and position this in the optimal location, and optimize the overall image to maximize the visibility of the endocardial border for speckle tracking analysis. Although 3D echocardiography may solve some of the limitations of 2D echocardiography, at present the frame rates are too low to obtain the necessary temporal resolution for quantification of myocardial deformation during exercise, although this is expected to change in the near future.
During exercise, when respiration and heart are increased, the quick location of the optimal echocardiographic window is necessary. Marking up the location on the chest after the resting assessment serves as a “quick help” during exercise. The sonographer must, however, still optimize the image and perhaps move the transducer slightly during exercise.
Since heart rate increases during exercise but imaging frame rates are already maximized, the effective frame rate (data points per cardiac cycle) decreases. Although this cannot be fully corrected, it seems advisable to perform cubic spline interpolation to attenuate some of these limitations [104]. Note that cubic spline interpolation will not only add points in time (for example for the more confident assessment of dyssynchrony), it also slightly adjusts the peak values.
Data acquisition immediately following exercise is not the same as “during” exercise. With the cessation of exercise, especially after a strenuous effort with strong muscular contractions, instant changes in whole-body hemodynamics set in [105]. Hence, these data do not reflect an exercise challenge but a “exercise recovery” state.
For the acquisition of LV twist, apical data must be obtained by moving the transducer close to the point of obtaining a 4-chamber view, otherwise severely misrepresentative data will be collected [24].
4. Summary and conclusions
The assessment of LV and RV myocardial deformation during exercise is feasible and has contributed unique insight into cardiac physiology in health and disease. Inherent methodological challenges require appropriate training and a careful approach to image acquisition, analysis and interpretation. However, ongoing technological advancements and an increasing knowledge suggest that the echocardiographic assessment of myocardial deformation during exercise will play an ever-increasing role in future research and the clinical examination of the cardiac patient.
Acknowledgments
The authors express their sincere gratitude to the publisher, IntechOpen, for their very kind and generous financial support of this chapter.
\n',keywords:"exercise, heart, stress testing, diagnostics, imaging, echocardiography, VO2max, CPET, strain, twist, torsion, untwisting rate, blood pressure, LVAD, heart failure, speckle tracking, hypertension",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/72623.pdf",chapterXML:"https://mts.intechopen.com/source/xml/72623.xml",downloadPdfUrl:"/chapter/pdf-download/72623",previewPdfUrl:"/chapter/pdf-preview/72623",totalDownloads:679,totalViews:0,totalCrossrefCites:0,dateSubmitted:"March 4th 2020",dateReviewed:"May 25th 2020",datePrePublished:"June 26th 2020",datePublished:"August 25th 2021",dateFinished:"June 26th 2020",readingETA:"0",abstract:"The human heart is an asymmetrical structure that consists of oblique, circumferential, and transmural fibers, as well as laminae and sheets. Sequential electrical activation of all the muscle fibers ultimately results in a coordinated contraction of the heart muscle also referred to as “deformation.” This is immediately followed by myocardial relaxation, when the preceding deformation is reversed, and the ventricles fill with blood. Given the complexity of these repetitive motions, it is not surprising that there is great diversity in the myocardial deformation between different individuals and between distinct populations. Exercise presents a natural challenge to determine the full capacity of an individual’s heart, and modern imaging technologies allow for the non-invasive assessment of myocardial deformation during exercise. In this chapter, the most relevant anatomical basis for myocardial deformation is summarized and definitions of the most relevant parameters are provided. Then, the general cardiac responses to exercise are highlighted before the current knowledge on myocardial deformation during exercise is discussed. The literature clearly indicates that the echocardiographic evaluation of myocardial deformation during exercise holds great promise for the identification of sub-clinical disease. Future studies should aim to determine the mechanisms of differential expression of myocardial deformation during exercise in health and disease.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/72623",risUrl:"/chapter/ris/72623",signatures:"Eric J. Stöhr and T. Jake Samuel",book:{id:"9581",type:"book",title:"Advanced Concepts in Endocarditis",subtitle:"2021",fullTitle:"Advanced Concepts in Endocarditis - 2021",slug:"advanced-concepts-in-endocarditis-2021",publishedDate:"August 25th 2021",bookSignature:"Michael S. Firstenberg and Umashankar Lakshmanadoss",coverURL:"https://cdn.intechopen.com/books/images_new/9581.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83968-480-7",printIsbn:"978-1-83968-479-1",pdfIsbn:"978-1-83968-481-4",isAvailableForWebshopOrdering:!0,editors:[{id:"64343",title:"Dr.",name:"Michael S.",middleName:null,surname:"Firstenberg",slug:"michael-s.-firstenberg",fullName:"Michael S. Firstenberg"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"319424",title:"Ph.D.",name:"Eric J.",middleName:null,surname:"Stöhr",fullName:"Eric J. Stöhr",slug:"eric-j.-stohr",email:"estohr@cardiffmet.ac.uk",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Cardiff Metropolitan University",institutionURL:null,country:{name:"United Kingdom"}}},{id:"321459",title:"Dr.",name:"T. Jake",middleName:null,surname:"Samuel",fullName:"T. Jake Samuel",slug:"t.-jake-samuel",email:"Thomas.Samuel@uta.edu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Principles of myocardial deformation",level:"1"},{id:"sec_2_2",title:"2.1 Anatomy",level:"2"},{id:"sec_3_2",title:"2.2 Definitions and selection of myocardial deformation parameters",level:"2"},{id:"sec_5",title:"3. Echocardiographic assessment of myocardial deformation during exercise",level:"1"},{id:"sec_5_2",title:"3.1 Why exercise?",level:"2"},{id:"sec_6_2",title:"3.2 General cardiovascular responses to exercise",level:"2"},{id:"sec_7_2",title:"3.3 Myocardial deformation during exercise",level:"2"},{id:"sec_7_3",title:"3.3.1 Physiological insight from healthy individuals",level:"3"},{id:"sec_8_3",title:"3.3.2 Exercise responses in patients with cardiovascular disease",level:"3"},{id:"sec_10_2",title:"3.4 Important practical considerations",level:"2"},{id:"sec_12",title:"4. Summary and conclusions",level:"1"},{id:"sec_13",title:"Acknowledgments",level:"1"}],chapterReferences:[{id:"B1",body:'Buckberg GD. Basic science review: The helix and the heart. The Journal of Thoracic and Cardiovascular Surgery. 2002;124(5):863-883'},{id:"B2",body:'Harvey W, Whitteridge G. Anatomical Disputation Concerning the Movement of the Heart and Blood in Living Creatures. 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Left ventricular myocardial response to exercise in children after heart transplant. The Journal of Heart and Lung Transplantation. 2014;33(12):1241-1247'},{id:"B92",body:'Esch BT, Scott JM, Warburton DE, Thompson R, Taylor D, Cheng Baron J, et al. Left ventricular torsion and untwisting during exercise in heart transplant recipients. The Journal of Physiology. 2009;587(Pt 10):2375-2386'},{id:"B93",body:'Pugliese NR, Fabiani I, Santini C, Rovai I, Pedrinelli R, Natali A, et al. Value of combined cardiopulmonary and echocardiography stress test to characterize the haemodynamic and metabolic responses of patients with heart failure and mid-range ejection fraction. European Heart Journal Cardiovascular Imaging. 2019;20(7):828-836'},{id:"B94",body:'Taylor BJ, Shapiro BP, Johnson BD. Exercise intolerance in heart failure: The important role of pulmonary hypertension. Experimental Physiology. 2020'},{id:"B95",body:'Bhatt SM, Wang Y, Elci OU, Goldmuntz E, McBride M, Paridon S, et al. 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Circulation. 2015;132(22):e262-e266'},{id:"B102",body:'Wisloff U, Stoylen A, Loennechen JP, Bruvold M, Rognmo O, Haram PM, et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: A randomized study. Circulation. 2007;115(24):3086-3094'},{id:"B103",body:'Rognmo O, Moholdt T, Bakken H, Hole T, Molstad P, Myhr NE, et al. Cardiovascular risk of high-versus moderate-intensity aerobic exercise in coronary heart disease patients. Circulation. 2012;126(12):1436-1440'},{id:"B104",body:'Burns AT, La Gerche A, Prior DL, MacIsaac AI.s Reduced and delayed untwisting of the left ventricle in patients with hypertension and left ventricular hypertrophy: A study using two-dimensional speckle tracking imaging. European Heart Journal. 2008;29(6):825-826'},{id:"B105",body:'Laugshlin MH. Cardiovascular response to exercise. The American Journal of Physiology. 1999;277(6 Pt 2):S244-S259'}],footnotes:[{id:"fn1",explanation:"In 2019, an exhibition across the UK celebrated the drawings by Leonardo da Vinci, including some of his anatomical sketches (https://www.rct.uk/collection/themes/exhibitions/leonardo-da-vinci-a-life-in-drawing/the-queens-gallery-palace-of)."},{id:"fn2",explanation:"The term mechanical is most commonly used in the literature on myocardial deformation. However, from a biophysical perspective, it may be more appropriate to refer to “kinematics”."}],contributors:[{corresp:"yes",contributorFullName:"Eric J. Stöhr",address:"estohr@cardiffmet.ac.uk;, ejs2212@cumc.columbia.edu",affiliation:'
School of Sport and Health Sciences, Cardiff Metropolitan University, UK
Division of Cardiology, Advanced Heart Failure Program, Columbia University Irving Medical Center, USA
Department of Kinesiology, University of Texas at Arlington, USA
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UK Research and Innovation (former Research Councils UK (RCUK) - including AHRC, BBSRC, ESRC, EPSRC, MRC, NERC, STFC.) Processing charges for books/book chapters can be covered through RCUK block grants which are allocated to most universities in the UK, which then handle the OA publication funding requests. It is at the discretion of the university whether it will approve the request.)
Wellcome Trust (Funding available only to Wellcome-funded researchers/grantees)
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However, despite the existing belief, there is no universal RFID system on the commercial market that could be used in all user applications. All components of a developed solution should be carefully selected or designed according to the specification of objects being recognized and characteristics of their environment. In order to determine parameters of propagation or inductively coupled system, especially when it is dedicated to uncommon applications, a multiaspect analysis has to be taken into consideration. Due to complexity, the problem is reduced to analytical or experimental determination of RFID system operation range and a “trial and error” method is mostly used in the industry practice. In order to cope with the barriers existing in the RFID technology, the authors give the review of latest achievements in this field. They focus on the definition, comprehensive characteristics and determination of the antenna parameters. They also pay attention to the 3D interrogation zone (IZ) that is the main parameter in which multitude technical aspects of the RFID systems are gathered simultaneously, as regards the theoretical synthesis as well as market needs.",book:{id:"5368",slug:"radio-frequency-identification",title:"Radio Frequency Identification",fullTitle:"Radio Frequency Identification"},signatures:"Piotr Jankowski-Mihułowicz and Mariusz Węglarski",authors:[{id:"5982",title:"Associate Prof.",name:"Piotr",middleName:null,surname:"Jankowski-Mihułowicz",slug:"piotr-jankowski-mihulowicz",fullName:"Piotr Jankowski-Mihułowicz"}]},{id:"66114",doi:"10.5772/intechopen.85075",title:"Combined Deep Learning and Traditional NLP Approaches for Fire Burst Detection Based on Twitter Posts",slug:"combined-deep-learning-and-traditional-nlp-approaches-for-fire-burst-detection-based-on-twitter-post",totalDownloads:828,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"The current chapter introduces a procedure that aims at determining regions that are on fire, based on Twitter posts, as soon as possible. The proposed scheme utilizes a deep learning approach for analyzing the text of Twitter posts announcing fire bursts. Deep learning is becoming very popular within different text applications involving text generalization, text summarization, and extracting text information. A deep learning network is to be trained so as to distinguish valid Twitter fire-announcing posts from junk posts. Next, the posts labeled as valid by the network have undergone traditional NLP-based information extraction where the initial unstructured text is converted into a structured one, from which potential location and timestamp of the incident for further exploitation are derived. Analytic processing is then implemented in order to output aggregated reports which are used to finally detect potential geographical areas that are probably threatened by fire. So far, the part that has been implemented is the traditional NLP-based and has already derived promising results under real-world conditions’ testing. The deep learning enrichment is to be implemented and expected to build upon the performance of the existing architecture and further improve it.",book:{id:"8511",slug:"cyberspace",title:"Cyberspace",fullTitle:"Cyberspace"},signatures:"Konstantinos-George Thanos, Andrianna Polydouri, Antonios Danelakis, Dimitris Kyriazanos and Stelios C.A. Thomopoulos",authors:null},{id:"66610",doi:"10.5772/intechopen.85362",title:"Text Mining to Facilitate Domain Knowledge Discovery",slug:"text-mining-to-facilitate-domain-knowledge-discovery",totalDownloads:1080,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"The high-precision observation and measurement techniques have accelerated the rapid development of geoscience research in the past decades and have produced large amounts of research outputs. Many findings and discoveries were recorded in the geological literature, which is regarded as unstructured data. For these data, traditional research methods have limited functions for integrating and mining them to make knowledge discovery. Text mining based on natural language processing (NLP) provides the necessary method and technology to analyze unstructured geological literature. In this book chapter, we will review the latest researches of text mining in the domain of geoscience and present results from a few case studies. The research includes three major parts: (1) structuralization of geological literature, (2) information extraction and visualization for geological literature, and (3) geological text mining to assist database construction and knowledge discovery.",book:{id:"8511",slug:"cyberspace",title:"Cyberspace",fullTitle:"Cyberspace"},signatures:"Chengbin Wang and Xiaogang Ma",authors:null}],mostDownloadedChaptersLast30Days:[{id:"68505",title:"Research Design and Methodology",slug:"research-design-and-methodology",totalDownloads:24839,totalCrossrefCites:7,totalDimensionsCites:16,abstract:"There are a number of approaches used in this research method design. The purpose of this chapter is to design the methodology of the research approach through mixed types of research techniques. The research approach also supports the researcher on how to come across the research result findings. In this chapter, the general design of the research and the methods used for data collection are explained in detail. It includes three main parts. The first part gives a highlight about the dissertation design. The second part discusses about qualitative and quantitative data collection methods. The last part illustrates the general research framework. 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Then, the chapter will discuss three aspects of 5G which are, namely, (1) Regulations, (2) security, and (3) the 5 enabling Technologies. Then, the chapter will discuss the real-life case of South Korea mobile carrier.",book:{id:"8511",slug:"cyberspace",title:"Cyberspace",fullTitle:"Cyberspace"},signatures:"Evon Abu-Taieh, Issam H. Al Hadid and Ali Zolait",authors:null},{id:"68561",title:"Cyberspace and Artificial Intelligence: The New Face of Cyber-Enhanced Hybrid Threats",slug:"cyberspace-and-artificial-intelligence-the-new-face-of-cyber-enhanced-hybrid-threats",totalDownloads:1236,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"While, until recently, cyber operations have constituted a specific subset of defense and security concerns, the synergization of cyberspace and artificial intelligence (AI), which are driving the Fourth Industrial Revolution, has raised the threat level of cyber operations, making them a centerpiece of what are called hybrid threats. The concept of hybrid threat is presently a key concern for the defense and security community; cyber-enabled and cyber-enhanced hybrid operations have been amplified in scope, frequency, speed, and threat level due to the synergies that come from the use of cyberspace and machine learning (ML)-based solutions. In the present work, we address the relevance of cyberspace-based operations and artificial intelligence for the implementation of hybrid operations and reflect on what this cyber dimension of hybrid operations implies for the concept of what constitutes a cyberweapon, the concept of hybrid human intelligence (hybrid HUMINT) and possible responses to the hybrid threat patterns.",book:{id:"8511",slug:"cyberspace",title:"Cyberspace",fullTitle:"Cyberspace"},signatures:"Carlos Pedro Gonçalves",authors:[{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves"}]},{id:"52156",title:"Case Study: Installing RFID Systems in Supermarkets",slug:"case-study-installing-rfid-systems-in-supermarkets",totalDownloads:2471,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Radio frequency identification technology (RFID) is considered as the reference technology for wireless identification and item traceability. Supermarkets are one of those scenarios where the RFID potential can be harnessed. In theory, RFID in supermarkets shows several advantages compared with traditional barcode systems, offering real‐time inventory, stock control, cash queues, among others. In practice, its massive and global implementation is still being delayed due to the high quantity of factors that degrade the RFID system performance in these scenarios, causing uncontrolled items and identification losses and, at the end, economical losses. Some works in the scientific literature studied a single or a set of problems related to RFID performance, mostly focused on a specific communication layer: antennas and hardware design, interferences at physical layer, medium access control (MAC) protocols, security issues, or middleware challenges. However, there are no works describing in depth the set of factors affecting RFID performance in a specific scenario and contemplating the entire communication layer stack. The first challenge of this chapter is to provide a complete analysis of those physical and environmental factors, hardware and software limitations, and standard and regulation restrictions that have a direct impact on the RFID system performance in supermarkets. This analysis is addressed by communication layers, paying attention to the point of view of providers, supermarket companies, and final customers. Some of the most feasible and influential research works that address individual problems are also enumerated. Finally, taking the results extracted from this study, this chapter provides a Guide of Good Practices (GGPs), giving a global vision for addressing a successful RFID implementation project, useful for researchers, developers, and installers.",book:{id:"5368",slug:"radio-frequency-identification",title:"Radio Frequency Identification",fullTitle:"Radio Frequency Identification"},signatures:"María-Victoria Bueno‐Delgado, Francesc Burrull and Pablo Pavón‐\nMariño",authors:[{id:"186584",title:"Dr.",name:"M.V.",middleName:null,surname:"Bueno-Delgado",slug:"m.v.-bueno-delgado",fullName:"M.V. 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He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. 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\r\n\tIf we aim to prosper as a society and as a species, there is no alternative to sustainability-oriented development and growth. Sustainable development is no longer a choice but a necessity for us all. Ecosystems and preserving ecosystem services and inclusive urban development present promising solutions to environmental problems. Contextually, the emphasis on studying these fields will enable us to identify and define the critical factors for territorial success in the upcoming decades to be considered by the main-actors, decision and policy makers, technicians, and public in general.
\r\n
\r\n\tHolistic urban planning and environmental management are therefore crucial spheres that will define sustainable trajectories for our urbanizing planet. This urban and environmental planning topic aims to attract contributions that address sustainable urban development challenges and solutions, including integrated urban water management, planning for the urban circular economy, monitoring of risks, contingency planning and response to disasters, among several other challenges and solutions.
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In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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