\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"3082",leadTitle:null,fullTitle:"Evapotranspiration - An Overview",title:"Evapotranspiration",subtitle:"An Overview",reviewType:"peer-reviewed",abstract:"Evapotranspiration - An Overview contains recent advances in the physics of evaporation and transpiration from a typical experimental site to large scale areas. It incorporates many years of authors experience with the latest research on the methods and the models used worldwide, engaging advanced technology and modern instrumentation. The reader benefits from the in-depth analysis and the diverse sites and settings, where the models, applications and methods are tested. Weather conditions, soil moisture, geology, climatic systems are examined for their role and influence on the theoretical and actual water demand by the atmosphere in the earth's ecosystem. This book not only provides students and scientists with the information to improve the procedures for estimating evapotranspiration, but will also help them to manage and evaluate the observed data.",isbn:null,printIsbn:"978-953-51-1115-3",pdfIsbn:"978-953-51-5369-6",doi:"10.5772/3383",price:119,priceEur:129,priceUsd:155,slug:"evapotranspiration-an-overview",numberOfPages:286,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"377ef031877b6f75a967a2b89a6c61b1",bookSignature:"Stavros G. 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His research interests include evapotranspiration, crop water conservation, techniques and applications in Agrometeorology. He has more than six years of teaching experience and has published a number of scientific and technical papers. Since 1983, he has made an active contribution in many European research projects (Ecological impact of the air pollution in Attica region, Monitoring of the sea water intrusion in the groundwater aquifers of Argolis Plain, Rational application of irrigation and drainage under Greek conditions, Validity, limits and possible trends of coastal South Mediterranean traditional groundwater irrigated agriculture, MEDEFLU, LOLaqua, DMCSEE, COROADO). He is a member of the Geotechnical Chambers of Greece, Greek Society of Soil Science and Hellenic Meteorological Society. 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\r\n\tTitanium alloys are used in the most advanced applications and to achieve greater everyday usage in all types of products, which is undoubtedly justified in terms of comprehending recent developments in their design, processing, and properties. These alloys are recognized as critical industrial structural materials and are effectively employed in a wide range of sectors such as automotive industries, aerospace, military, energy, and biomaterials. The optimization of material properties is based on a thorough understanding of physical metallurgy, alloys design processes, deformation mechanisms, the impact of extreme environments, or the interaction of protective layers and protected alloys, and is contextualized in relation to more recent development activities. This book will address the latest developments and potential applications of this lightweight, high-strength engineering alloy in terms of its design, processing, characterization, properties, and applications. Authors are encouraged to present papers on current achievements and the most significant contributions in modern titanium alloy grades that have the potential to influence future scientific innovation and research-based advancements in all fields.
",isbn:"978-1-80356-372-5",printIsbn:"978-1-80356-371-8",pdfIsbn:"978-1-80356-373-2",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"1c89c2e1b5d03b90db5b13d44479baa6",bookSignature:"Dr. Ram Krishna",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11466.jpg",keywords:"Extreme Temperature Application, High Strength, Corrosion Resistance, Electron Microscopy, Microstructure, Additive Manufacturing, Titanium Matrix Composite, Load-Displacement Curves, Selective Laser Melting, Sustainable Thermomechanical Processing, Weldability, Superplasticity",numberOfDownloads:7,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 22nd 2022",dateEndSecondStepPublish:"April 27th 2022",dateEndThirdStepPublish:"June 26th 2022",dateEndFourthStepPublish:"September 14th 2022",dateEndFifthStepPublish:"November 13th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"4 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Researcher in advanced materials and their advanced characterization techniques, Dr. Krishna completed his Ph.D. at the University of Leicester, UK, and held postdoctoral positions at the University of Manchester, UK, and North Carolina State University, US. 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It has been estimated that this condition affects around 3% of the population [3]. It takes place when the hallux has a lateral deviation, and the first metatarsal (1MT) deviates medially [4]. This condition has a clear predominance in women. According to different series, this entity is around nine times more frequent in women than in men [4, 5, 6].
\nHallux valgus deformity.
Different causes have been proposed as etiological factors of this deformity: genetic predisposition and intrinsic and extrinsic causes. While some studies have indicated [7, 8] that intrinsic factors (pes planus) play a major role in the etiology, others suggested that this plays a minor role in the development. The most important extrinsic cause is constricting footwear; it has been suggested that this pathology almost exclusively affects shoe-wearing societies [9, 10, 11]. Genetic predisposition has been implicated as a cause of hallux valgus in adults [12, 13].
\nThe primary symptom of hallux valgus is pain. It is often located in medial eminence because of bursal inflammation or skin irritation. Pressure from footwear is the most frequent cause of this discomfort.
\nPhysical examination should be performed with the patient standing and sitting. The deformity is often accentuated when the patient is standing bearing weight. The magnitude of the deformity should be recognized, as is any pronation of the hallux is present. The range of motion (passive and active) of the metatarsophalangeal joint should be noted [14]. If pain and crepitus are present when evaluating the metatarsophalangeal joint, it often indicates that degenerative injuries are present, and this could change the choice of the surgical technique. Some authors have stated that around 5% of the patients have hypermobility of the metatarsocuneiform joint (mobility of more than 9 mm), and this should be assessed as well as the neurovascular status [15, 16]. Lesser toe deformities are often associated and could be a cause of discomfort, and this should be evaluated.
\nPlain radiographs (AP and lateral) should be taken with the patient bearing weight (Figure 2). Angular measurement includes assessing of the hallux valgus angle (HVA), the first-second intermetatarsal angle (IMA), the distal metatarsal articular angle (DMAA), and the proximal phalangeal articular angle. The presence of osteoarthritis, joint congruity, and the amount of sesamoid subluxation are examined. All angular measurements should be made according to the guidelines set by the AOFAS Ad Hoc Committee on Angular Measurements [17]. The severity of the deformity can be classified as mild, moderate, or severe deformity [13].
\nAP X-ray. Moderate hallux valgus.
Non-operative treatment should be attempted. Symptoms are often relieved by reducing friction over the prominent medial eminence. Recommendations about patient’s footwear could be helpful; sometimes, a simple change in the type of shoes or size may reduce symptoms substantially [18]. Despite non-operative measures, some patients eventually need surgical treatment.
\nThere are numerous surgical procedures for correction of HV deformities, which indicates that there is not only one procedure that is universally applicable for all patients. Usually, the choice of the procedure depends upon how rigorous the deformity is and where it is located. Options include proximal, shaft, or distal metatarsal osteotomies (associated or not to lateral release). Osteotomies of the cuneiform, arthrodesis of the metatarsophalangeal joint, and excisional arthroplasty have also been described. Some of the aforementioned surgeries may be performed through open or percutaneous surgery (MIS).
\nDistal metatarsal chevron osteotomy is an excellent treatment option in mild-to-moderate deformities, providing good results in the correction of deformity and symptoms [19, 20, 21]. The radiographic indications are hallux valgus angle less than 40° and first-second intermetatarsal angle less than 20°. With this procedure, a resection of the medial eminence, a distal metatarsal osteotomy, and a medial capsuloplasty are used to realign the great toe. Johnson et al. [22] and others [23, 24, 25] have reported good to excellent results with this procedure. After this osteotomy, the average correction of the HVA has been reported to be 12–13°, and the average correction of the IMA has been 4–5° [26].
\nThis type of metatarsal osteotomy has some advantages: is stable, has a wide contact surface, has the ability to allow corrections of the DMAA, and admits weight bearing immediately after surgery [27]. However, it has some weakness due to a small power of deformity correction. To overcome this issue, an Akin phalangeal osteotomy and lateral soft tissue release can be added to augment angular correction [28, 29].
\nLateral soft tissue release can be achieved through different procedures (open or MIS, through a medial or dorsal approach). The goals of this surgical gesture are to eradicate the lateral deforming forces and allow a better realignment of the first metatarsophalangeal joint by cutting the latero-plantar capsule, the transverse metatarsal ligament, the adductor tendon, and the lateral metatarsosesamoid ligament [27].
\nSeveral complications have been described with the chevron osteotomy: undercorrection and recurrence of the deformity are the most frequent ones. Recurrence could happen when the surgical indications are not respected in terms of angular values, and more severe deformities are treated. Undercorrection can be caused by a secondary displacement at the osteotomy site. This was more frequent when no internal fixation was used, as the original technique described by Austin and Leventen [30]. Nowadays, internal fixation has shown to reduce the rate of loss of correction [22, 25].
\nShortening is another complication to consider, and it may occur when too much bone had been removed. Postoperative transfer metatarsalgia has been reported as a result of this complication [31].
\nThe most critical complication after a chevron osteotomy is an avascular necrosis (AVN) of the 1MT head. Some reports have shown an increased risk of AVN when lateral soft tissue release is combined with a distal chevron osteotomy [32, 33], although other studies state that this is a rare complication [34, 35]. The reported incidence of avascular necrosis (AVN) ranges between 0 and 20% [36, 37].
\nPercutaneous surgery of the foot, also known as minimal incision surgery or
The applications of percutaneous surgery in hallux valgus correction were first introduced in the 1970s and 1980s [39]. It has since evolved into endoscopic, minimum-incision, and percutaneous techniques. In the last 10 years, there has been a growing interest in percutaneous techniques for HV correction especially in Italy and Spain, at the beginning. First-generation percutaneous technique was described by Isham [39] in which no internal fixation was needed. The second-generation technique was a distal transverse osteotomy of the 1MT stabilized with an axial wire [40, 41]. Recently, some comparative studies evaluating these procedures received a degree of recommendation C (poor-quality evidence for or against recommending intervention), although these results are being reviewed due to the omission of relevant studies [41, 42, 43, 44]. The third-generation (TG) MIS involves procedures based on the design of chevron osteotomies with the need of screw fixation that has added extra stability and minor complications [45, 46].
\nForefoot MIS has experienced a vertiginous and sustained growth especially in the last decade. Clinical series and comparative studies have been published [47, 48, 49, 50]. Additionally, cadaveric results [51, 52], technique reports [53], and radiological validations [54, 55] have been described. Despite the fact that for some authors percutaneous surgery of the forefoot lacks scientific support [56, 57, 58], recently two systematic reviews published support its indication in hallux valgus surgery [43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59].
\nConsidering the indications and potential advantages of percutaneous surgery, some authors experienced with osteotomies similar to the open chevron, although with conceptual differences. They can be divided into intra- or extra-articular osteotomies.
\nSome examples of those performed proximal to the joint capsule (extracapsular) are as follows:
(A) AP view. Incongruous moderate hallux valgus. (B) MICA technique. (C) Intraoperative radioscopy. (D) Final lateral X-ray (courtesy of Dr. Vernois, Joel).
(A) Upon completion of the osteotomy, a designed ‘pry bar’ is introduced into the proximal canal via the site of the osteotomy to translate the metatarsal head in a lateral and plantar direction. (B) AP view. Final correction and fixation of the PERC and percutaneous Akin osteotomy. (C) Lateral radioscopic view. Obliquity of the fixation and MTT position (courtesy of Dr. Laffenêtre, Olivier).
(A and B) AP view. Mild-to-moderate HV. Correction achieved. (C and D) Clinical images. Pre and postop (courtesy of Dr. Laffenêtre, Olivier).
(A) Displacement of the metatarsal head. (B) Fixation with two screws; new technique and unpublished data (authorization of Dr. Laffenêtre, Olivier).
(A and B) Moderate HV. (C and D) Correction achieved with the PECA technique (courtesy of Lam, Peter).
An intra-articular technique has recently been described:
(A) Medial portal (P1). (B) Dorsal partial capsular detachment. (C) Entry point and perpendicular orientation of the Shannon burr. (D) Displacement of the metatarsal head using the ‘Bosch method’. (E) Location of P2.
(A) Orientation of K-wire. (B) 3.0 mm conic screw insertion. (C) Lateral release portal (P3). (D and E) Remnant medial exostosis and its resection.
(A) Symptomatic mild hallux valgus. (B) PICO technique. One week postoperative (POP). (C) POP bandage correction. (D and E) Week 8 POP. AP and Lateral view.
The ‘third-generation’ (TG) chevron techniques reliably mimics the open chevron procedure with all its known virtues while it does not reproduce its disadvantages and complications. There is no doubt that this group of techniques reflects the future of percutaneous hallux valgus surgery. In relation to the results shown, we can mention that TG techniques are useful, effective, and (maybe) easier than open procedures. We emphasize that percutaneous surgery has an extensive learning curve, and therefore it may be difficult to imitate the results shown on already-published data.
\nHuman teeth are the hardest substance in the human body that enhances the beauty of a person. It is a highly important structure that helps in food chewing to mechanically break down the food by cutting and crushing them in preparation for swallowing and digesting. It also aids in speech and its articulation of words. Human teeth consist of 20 primary (deciduous, “baby” or “milk”) teeth in children and 32 permanent teeth in adults. Teeth are classified as incisors, canines, premolars, and molars. Incisors are primarily used for cutting the food into pieces, canines are used for tearing the tissues of the food, and molars help to grind the food into smaller substances [1].
Teeth are also important for cosmetic purposes as well. Many dental treatments are not purposefully dealt with filling and taking out a tooth, but indeed nowadays people turn out to esthetic dentistry to improve, straighten, lighten, reshape, and repair teeth as well. The field of esthetic dentistry includes the establishment of veneers, crown bridges, implants, tooth-colored filling, and teeth whitening procedures.
Tooth exfoliation starts from childhood. A young boy or girl loses the baby teeth, and it gets exfoliated in response to permanent teeth that start developing beneath them. This loss of primary teeth begins around the age of six and continues till 12 years of age. The primary teeth that are vulnerable are the upper and lower lateral incisors that shed at 7–8 years and upper canines are that shed around 10–12 years of age. Only the upper and lower first molars shed at 9–11 years of age and upper and lower second molars shed at 10–12 years of age [2].
Tooth loss is a condition that advances with the increase of age. This occurs as a result of mechanical disturbances and abnormal forces that act during the chewing process of hard substances, traumatic injury, etc. Also, a few conditions such as untreated dental caries (tooth decay) and severe periodontal (gum) disease might lead to loss of permanent teeth. Tooth decay is the primary cause of tooth loss. It is caused by the increased plaque retention on the teeth followed by bacterial invasion of the plaque. This ultimately results in dental caries and the formation of cavities. Untreated tooth cavities for a chronic period of time lead to the breakdown of the tooth. This bacterial invasion and retention of plaque deposits also affects the gums and bones attached to the tooth and loses its ability to hold the tooth. Periodontal structures are tissues that support teeth and their attachment to the bone. Diseases of the gums and bones are caused by bacterial invasion of teeth and retention of plaque. It results in diseases of the gums leading to periodontitis and detachment of supporting structures of the teeth and eventually causes tooth loss. So, the ultimate care of oral hygiene is the only preventive measure to prevent tooth loss. Good oral hygiene is the process of maintaining proper brushing of teeth two times a day with fluoridated toothpaste and frequent flossing. Regular dental check-ups every 6 months can be availed to ensure good teeth and prevent tooth loss [3].
There are a few conditions like bruxism otherwise called teeth grinding that occurs during sleep. This condition is very common in people who tend to be awake by profession at night. This tooth grinding increases the wear and tear action on the tooth and causes mechanical injury. The risk of tooth fractures is common in sportspeople, especially in football and goalie. Research reports claim that smoking is another important cause of tooth loss. Reports from countries, such as the United States, Germany, and Japan, show a strong relationship between cigarette smoking and tooth loss. The habit of smoking weakens the body’s immune response to infection and causes immunosuppression. This makes it harder to guard against a gum infection and takes a longer time to heal. Reports reveal that systemic diseases also relate to tooth loss. Conditions, such as cardiovascular diseases, diabetes mellitus, cancer, and osteoporosis, also lead to permanent tooth loss due to their secondary complications. Therefore, tooth loss is not restricted to poor oral hygiene but poor maintenance of overall health [4, 5, 6].
Missing a permanent tooth is a miserable condition. Years after years the treatment options for missing teeth are dental implants, fixed dental bridges, removable partial dentures. Dental implants are considered as the prime option by dentists to replace a single tooth. This procedure involves the surgical mounting of a titanium metal post or frame on the upper or lower jaw along with mounting the replaced missing tooth. This dental implant acts as a permanent base for the replaced tooth. This procedure is highly advantageous because the replaced dental implant resembles a natural tooth and can last for decades. It also acts independently and does not disturb the adjacent normal tooth. The next treatment option is a fixed dental bridge. This procedure provides bridging between the gaps caused by the lost tooth and involves the employment of a dental prosthesis or an artificial tooth. This dental prosthesis would be attached to adjacent teeth and bonded in place with dental cement. A removable partial denture consists of replacement teeth that are attached to a natural-looking pink base. The natural teeth also act to stabilize and hold the removable plastic base in its position place. This pink base is designed in a way that matches the color of the gums and the color of the normal teeth [7].
A dental implant is a material placed in or on the oral tissues that help to support the oral prosthesis. An ideal implant material should possess the following characteristics. It should be biocompatible and possess adequate strength, rigidity, good corrosive, and be capable of wear and fracture resistance. The principles of designing a dental implant should be much compatible with the physical properties of the material. Materials that are used for fabricating a dental implant can be considered according to the chemical composition of the implant and their biological responses. Many reports claim that these dental implants may be made from metals, ceramics, or polymers [8].
According to the American Society for testing and materials, there are six distinct types of titanium that are widely available as implant biomaterials. They are grade I, II, III, IV Cp Ti, various combinations of titanium, aluminum like alpha-beta alloy containing 6% Al and 4% V, alpha-beta titanium alloy containing 6% aluminum and 7% niobium, alpha-beta titanium alloy with non-ferrous metal. The physical and mechanical properties, such as tensile strength and osseointegration, elastic modulus, non-toxic nature, are quite different for the different alloys. The most important property related to the oxygen residuals in the metals and the other two titanium is considered as very low interstitial alloys. Among all the available alloys, the commercially prepared pure titanium alloys are generally considered as pure and mentioned in Grade I, Grade II, Grade III, and Grade IV titanium and has wide applications in implant manufacturing. Some trace elements, such as carbon, oxygen, nitrogen, and iron, are also considered in this process. Although titanium possesses many strengthening characteristics, literature reports reveal that it evokes a stronger reaction in the host causing hypersensitivity reactions, failed implants with increased concentration of titanium in peri-implanted tissues, regional nodes, and pulmonary tissues based on animal models, allergy to titanium in the form of urticaria, pruritus of the mucosa or skin, atopic dermatitis, poor fracture healing, necrosis and immunosuppression and weakening of orthopedically implanted titanium [9].
Ceramics has been widely used as a dental implant coating and it was the first introduced material in the field of implant dentistry. Hydroxyapatite is one of the most known biocompatible materials commonly used as a coating for metal implants. These hydroxyapatite coatings create a good interfacial strength between bone and implant. It provides greater implant stability and improves bone healing that lies adjacent to implants. The use of hydroxyapatite improves the capacity of osseointegration and increases the rate of rehabilitation of patients. This method of implanting decreases the time from implant insertion to final reconstruction of the implant [10]. There are various methods to coat hydroxyapatite on implants, they include sol–gel coating, electrophoretic deposition, plasma spraying, sputter-deposition, and biomimetic precipitation. Ceramic materials that are used for dental implanting and coatings. The materials used are hydroxylapatite (HA), tricalcium phosphate, fluorapatite (FA), tetracalcium phosphate, calcium pyrophosphate, brushite, bioglasses, aluminum oxide, zirconium oxide, etc. (Figure 1).
SEM-image of hydroxyapatite.
In the field of dental implanting, metals are widely selected based on factors that involve properties belong to its biomechanical characteristics, machining characteristics, and surface finishing characteristics as well. In the present day, metals, such as Co-Cr, stainless steel, and gold are quite outdated in the dental implant industry and the currently available dental metals are alloys of titanium and zirconium as well. Certain components of dental implants such as the abutment screws and some attachments of the implants are also made of alloys of gold, stainless steel, and Co-Cr. Titanium is mostly considered as an effective material by most of the dentists for its wide intraosseous applications. It has enormous and typical properties, such as lesser readily affected or corroded by the environment, high resistance to chemical dosing, and capability to repair on its own. The resistance to being deformed elastically—modulus of elasticity was very compatible with that of bone and titanium oxide [11, 12]. Although titanium is a typical material suitable for dental implanting, it faces a lot of shortfalls. These drawbacks and detrimental properties of titanium ultimately resulted in prompting the scientists to look and research the new implant from other biomaterials [13].
The next innovation to overcome the said shortfalls led to the development of ceramic implants [14]. And as a result of this zirconia is used as another material for dental inserts. This in turn contrasted with metallic components zirconia demonstrated the least particle discharge and they are thought to be dormant in the body [15]. Zirconia acts as a tooth-like shading and possesses great mechanical properties and has great biocompatibility. In such a way, it is by all accounts an appropriate dental material [16]. The utilization of zirconia implants keeps a strategic distance from the inconvenience and acquiesces to the demand of numerous patients without metal inserts. The material additionally gives high quality, crack sturdiness, and biocompatibility [17]. There are various materials used for fabricating endosseous dental implants like titanium, titanium alloy, stainless steel, alumina, carbon, bioglass, polyurethane, etc. [18, 19, 20].
A novel implant, the ceria-stabilized zirconia-alumina-aluminate composite was developed and was established for its significant effect that it is not prone to aging. This implant represents a probable alternative to the yttrium-stabilized zirconia that is used for ceramic oral implants. This implant was evaluated for its long-term stability due to its make with Ce-TZP-comp and it proved a significant lowest fracture load after combined loading/aging [21].
A variety of polymers have been utilized as dental implant materials [22]. A portion of the polymer materials is polymethylmethacrylate, polytetrafluoroethylene, polyethylene, polyurethane, and polysulfone, etc. When polymer acts as a coating layer, inferior mechanical properties, lack of adhesion to living tissues, and adverse immunologic reactions are eliminated [23, 24, 25, 26]. In the present day, polymeric materials are constrained to assemble the shock retaining segments joined into the superstructures bolstered by inserts [26]. A wide variety of biomaterials have found profound applications in the form of inserts. This type of insert in implantology requires a suitable biomaterial of choice. The presently available biomaterials, such as bioceramics and other composite biomaterials, are under higher consideration and the precise examination of such biomaterial definitely have a promising future in the field of dental applications.
Herbal medicine is an indigenous system of traditional Hindu medicine and is native to the Indian subcontinent. Contemporary practices derived from ayurvedic traditions are also a type of alternative medicine. Ayurveda recommends some daily use therapeutic procedures for the prevention of and maintenance of oral health. It involves Dant Dhavani (brushing), Jivha Lekhana (tongue scrapping), and Gandoosha (gargling) or even oil pulling and tissue regeneration therapies. Various herbs are widely used in dentistry and they are aloe vera [27], cloves [28], eucalyptus [29], peppermint [30], and turmeric [31].
Icariin, one of the traditional Chinese herbal medicines, possesses significant evidence that it strengthens bones, enhances healing of bone, inhibits osteopenic effect, and inhibits inflammation. This idea made scientists incorporate icariin for better osseointegration of dental implants and shorten the rehabilitation time of patients and the results revealed that. Evaluation of the hypothesis: Limited success has been achieved to help implant surgery in icariin significantly improved the success rate of the dental implant [32].
Another randomized trial of preparing a biocomposite osteogenic nanofiber was developed with the incorporation of polycaprolactone, hydroxyapatite, dexamethasone, gelatin, beta-glycerophosphate, and ascorbic acid along with titanium implants was developed so that it mimics the bone extracellular matrix and eventually induced osteogenesis in the peri-implant niche and also regenerates the osseous tissue. This implant was worked on rabbit models and the results revealed that a coating of osteogenic nanofibrous tissues significantly increased the magnitude of osteogenesis around the zone of peri-implant tissue and also favored the dynamics of osseointegration [33].
Cassia occidentalis Linn belongs to the family Caesalpiniaceae and is commonly called Kasondi in Hindi. It is mostly grown in the southern parts of India and the plant products have been used for various ailments and have a rich medicinal value [34]. C. occidentalis (CO) contains significant bioactive compounds, such as terpenoids, anthraquinones, and carotenoids. The plant products were reported to stimulate mineralization of the bone and osteoblastic differentiation through the activation of the PI3K-Akt/MAPKs pathway in MC3T3-E1 cells of mice [35].
Another novel dental implant synthesized a nanohydroxyapatite using different methods by utilizing the biomolecules from waste products, such as an egg-shell. In this study, an institutional controlled synthesis of nano-sized HAP was performed, which can be employed in the future for another material synthesis thereby an improved bone bonding was obtained by this novel material [36]. A novel implant synthesized with nano HAP rods was performed by an
A prepared porous scaffold using nano HAP and nylon 6,6 using a salt-leaching technique was a newly handled technique. Here HAP was dispersed on the pore walls of the scaffold bonds well with nylon 6,6 and it increased the stiffness of the scaffold. This porous scaffold acts to be effective as a three-dimensional substrate for bone tissue engineering [38]. Another method developed on dental implanting includes the synthesis of biphospho-calcium phosphate (BCP) for calcium-deficient apatites, such as enamel, dentin, and bone mineral by a process of sintering. The prepared BCP had controlled bioactivity when the HAP/βTCP ratio was controlled. This form of BCP can be used as carriers for growth factors, drug delivery systems, and in tissue engineering [39].
Another preparation included natural porous bioceramics from processing the cancellous bone. Calcined bovine bone was treated with sodium pyrophosphate and sintered to obtain HAP and was in turn converted to βTCP and BCP. This process was done to improve and increase the bioactivity of the ceramics when placed
A newly evolved technique was prepared by using BCP with different HAP/βTCP ratios and was analyzed for its bioactivity with SBF solution and osteoconductivity in rabbits. The study found that BCP with a HAP/TCP ratio of 60:40 was found to be best in showing the bioactivity and osteoconductivity compared to pure HAP and other BCP ratios. A newly developed implant was created using a coating material for orthopedic metal implants. In this study, a new bioglass was prepared and coated on Ti-based and Co-Cr alloys. This was done to enhance the cell adhesion when placed
Another novel implant was prepared by using composite material consisting of poly-L-lactide (PLLA) and bioactive glass by solvent evaporation technique. The composite was bathed and soaked in SBF for 3 days for allowing the HAP deposition on the composite. The dried composite was subjected to various characterization techniques. The study found that the bioactivity of the composite was highly increased and it, in turn, supported the composite to promote bone integration when placed
Another group of researchers synthesized a composite containing chitosan, HAP, and bioglass. Chitosan-HAP composite was prepared using calcium nitrate and orthophosphoric acid in SBF. The novel prepared composite bioactive glass was added to this preparation.
Cassia occidentalis.
Another implant was prepared with a bioglass composite film consisting of poly (3-hydroxybutyrate) and vitamin E. The incorporation of vitamin E was done to increase the protein adsorption and hydrophilicity on the surface of the film. This composite film was subjected to various characterized studies and the results reported that they can be applied [45] in tissue engineering as a better matrix material for cell adhesion [46]. Chin et al. worked on preparing a novel multi-component skin substitute by using collagen as a matrix material which typically depicts the normal architecture of the skin. This implanting material has a main advantage in producing a cost-effective bone substitute. A novel prepared magnetic fibrin incorporated with nanoparticles and characterized those nanoparticles by various physicochemical techniques using Saos 2 cells, the cell viability, adhesion, and alkaline phosphatase assay. The study revealed that the [47] material exhibited good osteogenic property and hence it can be used in bone tissue engineering .
Auxenfans et al. [48], a researcher investigated a scaffold that contains collagen and glycosaminoglycans (GAG). The matrix was seeded with fibroblast and the study found that it forms a typical reconstructed skin or hemicornea once epithelialization completes. Another study analyzed the rate of degradation of pure collagen and collagen–HAP beads using collagenase enzyme. This enzyme was able to digest pure collagen quickly compared to collagen-HAP gel beads. The HAP provides resistance for quick degradation and the matrix structure could be maintained for a greater period and it supports the cell to adhere, proliferate, and then differentiate [49].
Another research study reported the collagen type II scaffolds by cross-linking with glutaraldehyde and scaffold without cross-linking with glutaraldehyde. The study explained that the scaffolds were seeded with chondrocytes and observed the interaction of cells with the scaffold. The cell adherence on the surface of the scaffold was high which was confirmed by SEM analysis [50]. Another implant using used barium sulfate and zirconia as additives to implant as a bone cement was created to enhance the visualization through X-ray imaging. The incorporation of these additives in bone cement helps to locate the material placed in the bone defect areas [51]. Brown et al. [52, 53] formulated a bone cement consisting of tetra calcium phosphate (TTCP) and dicalcium phosphate (DCPA or DCPD) with a P/L ratio of 4:1 and mixed with water. The mixture was allowed to set for 30 min which formed calcium-deficient HAP. The formed material was hardened and molded and has wide applications in craniofacial surgery. Yamaguchi et al. [54] suggested the inclusion of zinc along with bone cement which induces osteoblast formation at the localized area and eventually new bone formation happens. Another material was developed where Co-Cr alloy was coated with bioactive glass by a process of enameling. The coated alloy was immersed in SBF for 30 days to observe the deposition of HAP on its surface which eventually increases the bioactivity of the material. This has also had wide applications in the tissue engineering field [55].
Another new fabrication was created using a porous scaffold containing foam-like bioglass and poly (lactide-co-glycolide) PLGA. The scaffold showed high microporosity and also the material was favorable for cell adhesion and hence this scaffold was widely applied in tissue engineering [56]. Another researcher [57] also developed a scaffold containing BCP and agarose gel. He analyzed the compression behavior of the scaffold and found that agarose improved the property of BCP by imparting elasticity, ductility, and toughness to the material. Hence, this scaffold could be used in the tissue engineering process. Another researcher [58] too prepared a scaffold comprising of two proteins namely bovine serum albumin and alpha casein by a cold gelation process. The developed scaffold can perform better in its porosity, cytotoxicity, and swelling ratio and the pH changes unalters the scaffold performance. An Indian researcher [59] also prepared bone grafts containing fibrin functionalized graphene oxide (FGO) and graphene oxide (GO) on to which HAP was grown by wet precipitation method. An
Another Indian scientist team [60] prepared a bone substitute with the incorporation of the extracts of
The widely used dental implants are known for their unique characteristics. Recently, novel dental implants incorporated with herbal composites were evaluated by research scientists and revealed abundant evidence on such materials. These implants developed enhanced bone healing and strengthens the bone, accelerates osseointegration, inhibits osteopenia, and inhibits inflammation. These novel implants allow good biocompatibility, viability and shorten the rehabilitation time for the patients. The application of herbal composite inclusion in dentistry and its applications has a greater potential to improve the success rate of dental implant and allows the implications of biotechnology in implant dentistry.
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The importance of these compounds in wine is due to their large effect on the organoleptic attributes of wine. Phenolic compounds play a crucial role in the colour as well as mouthfeel properties of wines. UV-visible spectroscopy appears as a suitable technique for the evaluation of phenolic compounds’ properties and content. The ability of the phenolic ring to absorb UV light and the fact that some of the phenolic substances are coloured compounds, i.e. show absorption features in the visible region, make UV-visible spectroscopy a suitable technique to investigate and quantify grape and wine phenolic compounds. A number of analytical techniques are currently used for phenolic quantification. These include both simpler approaches (spectrophotometric determinations) as well as more complex methodologies such liquid chromatography analysis. Moreover, a number of spectroscopy applications have also been recently reported and are becoming popular within the wine industry. This chapter reviews information on the UV-visible spectral properties of phenolic compounds, changes occurring during wine ageing and also discusses the current UV-visible based analytical techniques used for the quantification of phenolic compounds in grapes and wine.",book:{id:"6878",slug:"frontiers-and-new-trends-in-the-science-of-fermented-food-and-beverages",title:"Frontiers and New Trends in the Science of Fermented Food and Beverages",fullTitle:"Frontiers and New Trends in the Science of Fermented Food and Beverages"},signatures:"Jose Luis Aleixandre-Tudo and Wessel du Toit",authors:[{id:"250919",title:"Dr.",name:"Jose Luis",middleName:null,surname:"Aleixandre-Tudo",slug:"jose-luis-aleixandre-tudo",fullName:"Jose Luis Aleixandre-Tudo"},{id:"261223",title:"Prof.",name:"Wessel",middleName:null,surname:"Du Toit",slug:"wessel-du-toit",fullName:"Wessel Du Toit"}]},{id:"38354",doi:"10.5772/48453",title:"Oxygen Scavengers: An Approach on Food Preservation",slug:"oxygen-scavengers-an-approach-on-food-preservation",totalDownloads:16173,totalCrossrefCites:8,totalDimensionsCites:47,abstract:null,book:{id:"1128",slug:"structure-and-function-of-food-engineering",title:"Structure and Function of Food Engineering",fullTitle:"Structure and Function of Food Engineering"},signatures:"Renato Souza Cruz, Geany Peruch Camilloto and Ana Clarissa dos Santos Pires",authors:[{id:"144206",title:"Dr.",name:"Renato",middleName:null,surname:"Cruz",slug:"renato-cruz",fullName:"Renato Cruz"},{id:"144215",title:"Dr.",name:"Ana Clarissa",middleName:null,surname:"Pires",slug:"ana-clarissa-pires",fullName:"Ana Clarissa Pires"},{id:"144219",title:"MSc.",name:"Geany",middleName:null,surname:"Camilloto",slug:"geany-camilloto",fullName:"Geany Camilloto"}]}],mostDownloadedChaptersLast30Days:[{id:"38363",title:"Pulsed Electric Fields for Food Processing Technology",slug:"pulsed-electric-fields-for-food-processing-technology",totalDownloads:29530,totalCrossrefCites:16,totalDimensionsCites:77,abstract:null,book:{id:"1128",slug:"structure-and-function-of-food-engineering",title:"Structure and Function of Food Engineering",fullTitle:"Structure and Function of Food Engineering"},signatures:"Maged E.A. Mohamed and Ayman H. Amer Eissa",authors:[{id:"147638",title:"Dr.",name:"Maged",middleName:"E. A.",surname:"Mohammed",slug:"maged-mohammed",fullName:"Maged Mohammed"}]},{id:"66671",title:"Extraction and Purification of Pectin from Agro-Industrial Wastes",slug:"extraction-and-purification-of-pectin-from-agro-industrial-wastes",totalDownloads:2765,totalCrossrefCites:1,totalDimensionsCites:9,abstract:"With the advent of science and technology, agro-industrial wastes are converted into various value-added products to meet the demands of increasing population. In recent years, natural polymers have evoked tremendous interest due to easy conversion into value-added products. Apart from various natural polymers, pectin occupied a prominent place due to diverse pharmaceutical and therapeutic applications. Excess utilisation of pectin, the gap between production and demand is widening. To fulfil this gap various techniques are adopted for obtaining high yield pectin from various agro-industrial wastes. This chapter will be focusing on extraction and purification of pectin from various agro-industrial wastes, considered as main environmental pollutants.",book:{id:"8504",slug:"pectins-extraction-purification-characterization-and-applications",title:"Pectins",fullTitle:"Pectins - Extraction, Purification, Characterization and Applications"},signatures:"Erumalla Venkatanagaraju, N. Bharathi, Rachiraju Hema Sindhuja, Rajshree Roy Chowdhury and Yarram Sreelekha",authors:null},{id:"69396",title:"Soybean Amino Acids in Health, Genetics, and Evaluation",slug:"soybean-amino-acids-in-health-genetics-and-evaluation",totalDownloads:1421,totalCrossrefCites:0,totalDimensionsCites:6,abstract:"Soybean is an important source of protein and amino acids for humans and livestock because of its well-balanced amino acid profile. This chapter outlines the strengths and weaknesses of soybean as a complete amino acid source as well as the relative importance of individual amino acids. Special attention is paid to the sulfur-containing amino acids, methionine and cysteine. Breeding and genetic engineering efforts are summarized to highlight previous accomplishments in amino acid improvement and potential avenues for future research. Agronomic properties and processing methods that affect amino acid levels in soybean food and feed are also explained. A brief introduction into current amino acid evaluation techniques is provided. By understanding the complexities of amino acids in soybean, protein quality for humans and livestock can be maximized.",book:{id:"6972",slug:"soybean-for-human-consumption-and-animal-feed",title:"Soybean for Human Consumption and Animal Feed",fullTitle:"Soybean for Human Consumption and Animal Feed"},signatures:"William Monte Singer, Bo Zhang, M.A. Rouf Mian and Haibo Huang",authors:[{id:"308970",title:"Mr.",name:"William",middleName:null,surname:"Singer",slug:"william-singer",fullName:"William Singer"},{id:"309005",title:"Dr.",name:"Bo",middleName:null,surname:"Zhang",slug:"bo-zhang",fullName:"Bo Zhang"},{id:"310776",title:"Dr.",name:"M.A. Rouf",middleName:null,surname:"Mian",slug:"m.a.-rouf-mian",fullName:"M.A. Rouf Mian"},{id:"310777",title:"Dr.",name:"Haibo",middleName:null,surname:"Huang",slug:"haibo-huang",fullName:"Haibo Huang"}]},{id:"56975",title:"Metabolic Processes During Seed Germination",slug:"metabolic-processes-during-seed-germination",totalDownloads:6220,totalCrossrefCites:29,totalDimensionsCites:63,abstract:"Seed germination is crucial stage in plant development and can be considered as a determinant for plant productivity. Physiological and biochemical changes followed by morphological changes during germination are strongly related to seedling survival rate and vegetative growth which consequently affect yield and quality. This study is aimed to focus on proceeding of the most vital metabolic processes namely reserve mobilization, phytohormonal regulation, glyoxylate cycle and respiration process under either stressful or non-stressful conditions that may be led to suggest and conduct the more successful experimental improvements. Seed imbibition triggered the activation of various metabolic processes such as synthesis of hydrolytic enzymes which resulted in hydrolysis of reserve food into simple available form for embryo uptake. Abiotic stresses potentially affect seed germination and seedling establishment through various factors, such as a reduction in water availability, changes in the mobilization of stored reserves, hormonal balance alteration and affecting the structural organization of proteins. Recent strategies for improving seed quality involved classical genetic, molecular biology and invigoration treatments known as priming treatments. H2O2 accumulation and associated oxidative damages together with a decline in antioxidant mechanisms can be regarded as a source of stress that may suppress germination. Seed priming was aimed primarily to control seed hydration by lowering external water potential, or shortening the hydration period.",book:{id:"6096",slug:"advances-in-seed-biology",title:"Seed Biology",fullTitle:"Advances in Seed Biology"},signatures:"Awatif S. Ali and Alaaeldin A. Elozeiri",authors:[{id:"207241",title:"Dr.",name:"Awatif",middleName:null,surname:"Ali",slug:"awatif-ali",fullName:"Awatif Ali"}]},{id:"51587",title:"Casein Proteins: Structural and Functional Aspects",slug:"casein-proteins-structural-and-functional-aspects",totalDownloads:4870,totalCrossrefCites:17,totalDimensionsCites:42,abstract:"Mammalian milk is a complex fluid mixture of various proteins, minerals, and lipids, which play an important role in providing nutrition and immunity to the newborn. Casein proteins, which form about 80% of the bovine milk proteins, form large colloidal particles with calcium phosphate to form casein micelles, which for many years have been an important subject of interest. Casein micelles are composed of four main types of proteins: αS1‐casein, αS2‐casein, β‐casein, and k‐casein. These constituent casein proteins lack well‐defined secondary and tertiary structure due to large amount of propyl residues. These micelles are being extensively studied because of their importance in functional behavior of milk and various milk products. However, the exact structure and nature of these casein micelles are still under debate. These different casein proteins possess different functional properties due to their primary amino acid sequence.",book:{id:"5060",slug:"milk-proteins-from-structure-to-biological-properties-and-health-aspects",title:"Milk Proteins",fullTitle:"Milk Proteins - From Structure to Biological Properties and Health Aspects"},signatures:"Mohd Younus Bhat, Tanveer Ali Dar and Laishram Rajendrakumar\nSingh",authors:[{id:"178323",title:"Dr.",name:"Laishram R",middleName:null,surname:"Singh",slug:"laishram-r-singh",fullName:"Laishram R Singh"},{id:"183444",title:"Mr.",name:"Md. Younus",middleName:null,surname:"Bhat",slug:"md.-younus-bhat",fullName:"Md. 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:{name:"Medical University Plovdiv",country:{name:"Bulgaria"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"243698",title:"Dr.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:null,institution:null},{id:"7227",title:"Dr.",name:"Hiroaki",middleName:null,surname:"Matsui",slug:"hiroaki-matsui",fullName:"Hiroaki Matsui",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Tokyo",country:{name:"Japan"}}},{id:"312999",title:"Dr.",name:"Bernard O.",middleName:null,surname:"Asimeng",slug:"bernard-o.-asimeng",fullName:"Bernard O. Asimeng",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}}]}},subseries:{item:{id:"88",type:"subseries",title:"Marketing",keywords:"Consumer Trends, Consumer Needs, Media, Pricing, Distribution, Branding, Innovation, Neuromarketing",scope:"