The rapid development in radiological examinations has opened a new chapter in colorectal surgery. Unlike classical books, in this section we preferred to use more modern and everyday practical methods such as endoscopy or magnetic resonance imaging or endorectal ultrasonography, rather than sparing less used examinations such as X-rays and barium graphs.
- colorectal cancer
- diagnostic tests
A rectosigmoidoscopy is an examination of the rectum and pelvic colon with a sigmoidoscope. In this procedure an endoscopic vision equipment is introduced for visualization of the anus, rectum and sigmoid colon. No special preparation is required, except “fleet-enema” applications. It is helpful in the research of hemorrhoidal disease, as well as in the diagnosis of diseases of the rectum and the first portions of the large bowel, for example, Crohn’s disease, ulcerative rectocolitis, diverticula, polyps and colorectal cancer.
Colonoscopy is an examination of lower part of the alimentary tract. Colonoscopy is a safe procedure that gives information other tests may not be able to give. Often, people have colonoscopy as a screening test to check for polyps or cancer in the colon or rectum .
When the risks of the colonoscopy outweigh the expected benefits.
Consent cannot be obtained for a non-urgent procedure.
A perforation is known or suspected.
Documented acute diverticulitis.
It is important that the expected benefits of colonoscopy be carefully weighed against the risks, particularly in older adults and patients with comorbid illnesses because these patients are at increased risk for serious complications from colonoscopy. A suspected poor preparation is a relative contraindication to colonoscopy.
1.3. Patient preparation
1.4. Virtual colonoscopy
Computed tomographic colonography gives a computer-simulated endoluminal vision of air-filled distended colon. This technique uses both spiral or helical CT scan images acquired as an uninterrupted volume of data and employs sophisticated post-processing software to generate images that allow the operator to evaluate a cleansed colon in any chosen direction .
Screening for colorectal cancer: virtual colonography is an method for colorectal cancer screening in asymptomatic patients over the age of 50 years. There is consensus that CT colonography should not be used for screening in patients at increased risk for colorectal cancer (e.g., history of adenomas, inflammatory bowel disease, familial colorectal cancer syndrome).
Evaluation for synchronous colorectal cancer: in patients with a colorectal cancer in whom a complete colonoscopy cannot be performed due to the inability to pass the colonoscope beyond an obstructing tumor, a CT colonography can rule out a proximal synchronous colorectal cancer (Figure 3).
Evaluation of patients with signs or symptoms suggestive of colorectal cancer: while colonoscopy is the preferred initial diagnostic test in patients with signs or symptoms of a colorectal cancer as it permits biopsy of the lesion, a CT colonography may be performed in patients with an incomplete or failed colonoscopy or in whom a colonoscopy is contraindicated [13, 14].
Evaluation of with signs or symptoms suggestive of divertiküler disease.
Active colonic inflammation
Symptomatic colon-containing abdominal wall hernia
Recent acute diverticulitis
Recent colorectal surgery
Recent deep endoscopic biopsy/polypectomy/mucosectomy
Known or suspected colonic perforation
Symptomatic or high-grade bowel obstruction
Even with the use of cathartic colon preparations, retained fluid in the lumen may obscure or mimic small polyps. Residual material is therefore tagged with oral administration of water-soluble contrast alone (typically with several meals prior to the examination) or in combination with a low-volume barium contrast agent. The contrast-enhanced residual material can then be differentiated from the surrounding colonic mucosa. While bowel preparation is required at the present time, CT colonography without a cathartic bowel preparation is also being evaluated .
Following this, an uninterrupted volume of data is then acquired through the abdomen in several seconds during a single breath-hold. Because of the presence of stool, fluid, or bowel spasm, data are often acquired in both the supine and prone positions in order to redistribute fluid and colonic gas, thereby facilitating polyp detection. Scanning parameters are designed to cover a large volume of data with thin slices in order to optimize subsequent image reformation.
Intravenous injection of iodinated contrast medium is reserved for patients with known colorectal cancer in order to improve staging, in patients with symptoms of colorectal cancer, or in whom the extracolonic organs need to be further evaluated.
1.6. Capsule endoscopy
Capsule endoscopy is a noninvasive diagnostic method and designed for imaging of the small intestine, which is hard to visualize. Images of esophagus, stomach, and proximal colon can also be obtained. Images have a 1:8 amplification and resolution is higher than conventional endoscopes. This better images allow visualization of individual villi. Capsule endoscopy gives the concept of physiological endoscopy since the capsule moves in a passive state, does not inflate the bowel, and get images of the mucosa in the collapsed state. Capsule endoscopy is usually used for the diagnosis of small intestine disorders.
1.6.1. Small bowel capsule endoscopy
Dementia, gastroparesis, an esophageal stricture or swallowing disorders, those patients who are inoperable or refuse surgery, partial or intermittent small bowel obstruction, patients who have defibrillators or pacemakers and pregnant women [20, 21].
1.6.2. Colon capsule endoscopy
A colon capsule for the screening of colorectal cancer has been approved by the US Food and Drug Administration and by the European Medicines Agency. Guidelines suggest that colon capsule endoscopy is a suitable and good alternative to colonoscopy for colorectal cancer in average-risk patients. However, it is not recommend for patients at increased risk for colon cancer or for patients with alarm symptoms .
Like conventional colonoscopy, a bowel preparation should be given to patients. The evening prior to the examination, patients should take about 3 L of polyethylene glycol. The morning of the procedure, the patient drinks another liter of polyethylene glycol between 6:00 and 7:00 am, and then the capsule is ingested at 8:00 am. Additional drugs (phospho soda and bisacodyl) can be given during the procedure for increasing transit of the capsule .
The colon capsule can be used to screen for colon cancer and polyps. Unfortunately, colonic capsule endoscopy cannot allow for biopsy polyp removal. Colonoscopy is required for lesions detected during the colon capsule endoscopy, subsequently for further evaluation and/or treatment.
2. Magnetic resonance imaging
Magnetic resonance imaging (MRI) is one of the most important methods for local staging of patients with rectal cancer. There are three different modalities of MRI as body coil MRI, endorectal coil MRI and pelvic phased-array coil MRI. Body coil MRI is not superior to CT scan in staging and it is insufficient in local staging.
ERC-MRI is used to provide images of the rectum and the area surrounding the rectum with a probe inserted into the rectum through the anal canal. ERC-MRI is an important method for staging of the anal canal and rectal cancers and diagnosis of anorectal fistulas and abscesses. ERC-MRI can make T-staging with an accuracy of 70–90% particularly for T1–T2 and early T3 tumors . Despite this, likelihood of success in evaluation of T3 and T4 tumors decreases due to narrow field of view and implementation difficulty of ERC-MRI. Additionally, endorectal coil MRI cannot visualize the mesorectal fascia and it is an important disadvantage. Likelihood of success is less in conditions where the patient is noncompliant and not tolerating anal coil insertion, in tumors with a longitudinal length of more than 5 cm, tumors invading ¾ of the lumen, tumors located above the level of 10 cm from the anal verge .
More detailed images were obtained by using pelvic phased-array coil MRI (PP-MRI) which was developed recently and providing high-resolution images. Thus, local staging of rectal tumor resulted in a higher accuracy rate. Obtaining a wide angled image is its superiority to endorectal coil MRI.
Distension of rectal lumen and rectal wall with use of preoperative intrarectal contrast material such as water or gel, air insufflation, premedication with spasmolytic agents improve the quality of both of ERC-MRI and PP-MRI .
T-staging: The accuracy rate of staging performed with PP-MRI is markedly higher compared to CT. Excellent imaging of layers of the rectal wall, mesorectum and mesorectal fascia particularly in middle and upper rectal cancers improved description of T3 tumors.
It is very important to be able to determine the distance between the mesorectal fascia and tumor in detail as mm for local recurrence. This distance shows compliance reaching 95% with pathological measurement performed in specimen removed by using PP-MRI and total mesorectal excision. This feature enabled us to make preoperative substaging of T3 tumors . In T3 tumors, if tumor invasion into the mesorectum is <5 mm then tumor is classified as T3a and if it is >5 mm then tumor is classified as T3b. While less number of lymph node involvement was observed in T3a tumors, lymph node involvement was seen in a more aggressive manner in T3b tumors. PP-MRI fell behind endoanal ultrasonography to show the relationship between the tumor and the anal sphincter muscles particularly in patients requiring intersphincteric resection.
Besides, endoanal ultrasonography is more successful than PP-MRI in discrimination between T1 tumor and T2 tumor in lower rectal cancers compared to PP-MRI.
N-staging: Regardless of T stage, N positivity shows locally advanced tumor and there is also a higher risk of local recurrence. These patients are candidates for neoadjuvant hormone therapy. Distinguishing tumor and involved lymph node from reactive lymph node is important. PP-MRI has a success rate reaching 85% in evaluation of lymph node.
3. Contraindications for MRI
|1. Presence of pacemaker||1. Pregnancy|
|2. Cochlear implant||2. Claustrophobia|
|3. Metallic implant/object in the eyeball||3. Metallic implant/object in the soft tissue|
|4. If communication cannot be established with patient||4. Prosthetic heart valve|
|5. Dental implant|
|6. Intrauterine device|
|7. Monitored patient|
|8. Permanent makeup and tattoo|
4. Endorectal ultrasonography
ERUS is being increasingly commonly used as a method in preoperative staging of rectal cancer. It is an ultrasonic method enabling simultaneous investigation of rectal wall layers and perirectal tissues in a 360° axis with a probe inserted into the rectum. A probe within a balloon inflated with water and inserted into the rectum detect the sound waves echoes of its own level by continuously rotating 360°. Axial length of tumor, its extension into rectal wall layers (T) and lymph nodes in perirectal tissues (N) are detected by moving the probe forward and backward through the anal canal and rectum (Figure 4). The structures of anal sphincters are established at the level of anal canal. The relationship between the tumor and anal sphincter is determined. However, inability to visualize the mesorectal fascia is the most important disadvantage. Therefore, it causes errors in staging of advanced T3 and T4 tumors. Besides, the lymph nodes far from the rectum may not be determined. Additionally, since higher staging can be made an erroneously, care should be exercised during interpretation of locally advanced cancer or desmoplastic tumors .
The other negative aspects of ERUS are as followings: inability to use in obstructive tumors, decline in diagnostic accuracy of T-staging in patients undergoing preoperative radiotherapy due to increased echogenicity of the rectal wall .
Lymph node staging by ERUS is problematic. It is difficult to determine whether lymph node is metastatic or not. Sensitivity and specificity of ERUS in determining lymph node are approximately 55 and 78%; respectively .
The accuracy rate of ERUS in determining perirectal lymph node is about 70 and 75%. If sonographic appearance of lymph node is round in shape and its size is greater than 1 cm, it is suggestive of a malignancy. Malignant lymph nodes are hypoechoic and hypervascular. Lymph nodes with a diameter of greater than 0.5 cm are 50–70% malignant, the probability of malignancy is less than 20% if its diameter is less than 4 mm .
When ERUS, MRI and CT are compared for staging of rectal cancer, a marked superiority of ERUS and MRI is observed in T and N-staging compared to CT. While the accuracy rates of CT, ERUS and endorectal coil MRI in T-staging were reported to be 73, 87 and 84%, respectively; the accuracy rates of CT, ERUS and endorectal coil MRI in N-staging were reported to be 66, 74 and 82%, respectively .
Also localization and size of tumor affect the accuracy rates of methods. While the results with ERUS are better in tumors located within the 1/3 lower part of the rectum, PP-MRI provides a higher rate of accuracy in the middle and upper rectum. While ERUS is better in T1 and T2, a more detailed evaluation can be performed with PP-MRI in T3 and T4. Currently, since importance of the distance of the tumor to the mesorectal fascia became evident, the value of PP-MRI in local staging increased. Because, ERUS cannot visualize the mesorectal fascia. This is an important part of evaluation which will be performed before decision-making process for neoadjuvant chemotherapy. Performing PP-MRI in the preoperative assessment of rectal tumors should be considered mandatory. However, there is a risk for higher staging (due to desmoplastic reaction). This might cause initiation of unnecessary neoadjuvant chemotherapy in some patients. ERUS is superior in assessment of anal sphincter involvement.
In conclusion, when these two stagings are performed together the accuracy rate in local staging increases, in other words these two methods are complementary. Reporting higher or lower stage T is in question for both methods. This can be observed much more in PP-MRI for discrimination of T2/T3 and in ERUS for discrimination of T3/T4. In recent years, tumor extension can be determined well with development of three-dimensional ERUS.
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