Equipment parameters.
\r\n\tThus, we call for research and review papers on the chemistry and physics of dyes, pigments, and their intermediates, including chemical constituents, spectroscopic aspects, surface, solution, crystal formation, photochemical, and ecological or biological properties. The book will be of interest to a wide variety of researchers worldwide whose work involves various fields of activity such as dyes and pigment synthesis, imaging, sensor, energy, medicine, polymers, food product, toxicological properties, etc.
",isbn:"978-1-83768-114-3",printIsbn:"978-1-83768-113-6",pdfIsbn:"978-1-83768-115-0",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"fcd069956c2e931195925b19a74ce9a3",bookSignature:"Dr. Brajesh Kumar",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/12081.jpg",keywords:"Heterocycles Pigments, Azo, Nitro, Indigo, Alizarin, Chromophores, Chromophores, Photochemical, Sulphonation, Diazotisation, UV-Vis Spectroscopy, Metal-Ligand",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 19th 2022",dateEndSecondStepPublish:"June 16th 2022",dateEndThirdStepPublish:"August 15th 2022",dateEndFourthStepPublish:"November 3rd 2022",dateEndFifthStepPublish:"January 2nd 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"14 days",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. Brajesh Kumar has worked as a faculty member in various universities in India, Ecuador, and South Korea. He has published numerous SCI/SCIE/Scopus research articles and is an active reviewer of more than 50 Journals. Dr. Kumar is a member of the American Chemical Society, the Indian Society of Chemists and Biologists, and the Indian Science Congress Association and holder of two registered patents. He is included in the top 2% of the scientist list prepared by experts at Stanford University,",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"176093",title:"Dr.",name:"Brajesh",middleName:null,surname:"Kumar",slug:"brajesh-kumar",fullName:"Brajesh Kumar",profilePictureURL:"https://mts.intechopen.com/storage/users/176093/images/system/176093.JPG",biography:"Dr. Brajesh Kumar is currently working as an Assistant Professor and Head in the Post Graduate Department of Chemistry, TATA College, Chaibasa, India. He received a Ph.D. in Chemistry from the University of Delhi, India. His research interest is in the development of sustainable and eco-friendly techniques for (a) nanoparticles synthesis and their applications for environmental remediation, (b) active films of organic solar cells, (c) nanomedicine, (d) sensors, (e) natural product extraction, purification, and analysis,(f) natural polymers, (g) peptide chemistry, (h) microwave and ultrasound-assisted organic synthesis and (i) organic synthesis. Dr. Brajesh Kumar has been credited for different national and international fellowships and he has also worked as a faculty member in various universities of India, Ecuador, and South Korea. He has also published numerous SCI/ SCIE/ Scopus research articles (h index = 28, Citations 2690) and is also an active reviewer of more than 50 Journals. He is also included in the top 2% of the scientist list prepared by experts at Stanford University, USA.",institutionString:"TATA College, Kolhan University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"2",institution:null}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"8",title:"Chemistry",slug:"chemistry"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"444318",firstName:"Nika",lastName:"Karamatic",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/444318/images/20011_n.jpg",email:"nika@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"117",title:"Artificial Neural Networks",subtitle:"Methodological Advances and Biomedical Applications",isOpenForSubmission:!1,hash:null,slug:"artificial-neural-networks-methodological-advances-and-biomedical-applications",bookSignature:"Kenji Suzuki",coverURL:"https://cdn.intechopen.com/books/images_new/117.jpg",editedByType:"Edited by",editors:[{id:"3095",title:"Prof.",name:"Kenji",surname:"Suzuki",slug:"kenji-suzuki",fullName:"Kenji Suzuki"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3828",title:"Application of Nanotechnology in Drug Delivery",subtitle:null,isOpenForSubmission:!1,hash:"51a27e7adbfafcfedb6e9683f209cba4",slug:"application-of-nanotechnology-in-drug-delivery",bookSignature:"Ali Demir Sezer",coverURL:"https://cdn.intechopen.com/books/images_new/3828.jpg",editedByType:"Edited by",editors:[{id:"62389",title:"PhD.",name:"Ali Demir",surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"872",title:"Organic Pollutants Ten Years After the Stockholm Convention",subtitle:"Environmental and Analytical Update",isOpenForSubmission:!1,hash:"f01dc7077e1d23f3d8f5454985cafa0a",slug:"organic-pollutants-ten-years-after-the-stockholm-convention-environmental-and-analytical-update",bookSignature:"Tomasz Puzyn and Aleksandra Mostrag-Szlichtyng",coverURL:"https://cdn.intechopen.com/books/images_new/872.jpg",editedByType:"Edited by",editors:[{id:"84887",title:"Dr.",name:"Tomasz",surname:"Puzyn",slug:"tomasz-puzyn",fullName:"Tomasz Puzyn"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3569",title:"Biodegradation",subtitle:"Life of Science",isOpenForSubmission:!1,hash:"bb737eb528a53e5106c7e218d5f12ec6",slug:"biodegradation-life-of-science",bookSignature:"Rolando Chamy and Francisca Rosenkranz",coverURL:"https://cdn.intechopen.com/books/images_new/3569.jpg",editedByType:"Edited by",editors:[{id:"165784",title:"Dr.",name:"Rolando",surname:"Chamy",slug:"rolando-chamy",fullName:"Rolando Chamy"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"59177",title:"Sequential Classification of Hyperspectral Images",doi:"10.5772/intechopen.73160",slug:"sequential-classification-of-hyperspectral-images",body:'Hyperspectral imaging is a continuously growing area and has received considerable attention in the last decade. Hyperspectral data provide a wide spectral range, coupled with a high-spectral resolution. These characteristics are suitable for detection and classification of surfaces and chemical elements in the observed images. Rich information in spectral dimension provides solutions to many problems that cannot be solved by traditional RGB imaging or multispectral imaging.
Applications include land use analysis, pollution monitoring, wide-area reconnaissance, and field surveillance, to cite a few. Typical cases related to food quality, agriculture, and environment include as follows:
Food safety plays an important role in our daily life. We often use a combination of appearance, hand-feel, and smell of the product to make a judgment of the quality of fruits or vegetables. But it is not enough to judge if there are abnormalities, deformations, or even visible defects in the fruit or vegetable. Awareness about food safety has exemplified the requirement for a rapid and accurate hyperspectral detection system [1].
Precision agriculture is a farming management concept based on observing, measuring, and inter and intrafield variability in crops. Precision agriculture using hyperspectral remote sensing is acquired and processed to derive maps of crop biophysical parameters, to measure the amount of plant cover, and to distinguish between crops and weeds [2].
Due to the pressures of over consumption, population, and technology, the biophysical environment is being degraded, sometimes permanently. Many of the earth’s resources are on the verge of exhaustion because they are influenced by human impacts across many countries [3]. Many attempts are made to prevent damage or manage the impacts of human activity on natural resources. Hyperspectral classification used in resource recovery can make it rapid and efficient.
One of the most important tasks of hyperspectral image processing is image classification. Rich spectral information of hyperspectral image provides the possibility to classify materials that are difficult to be distinguished by other imagery techniques. In the past decades, different kinds of hyperspectral classification methods have been proposed [4, 5, 6, 7, 8, 9]. However, the existed methods may not be suitable for a real-time material sorting system. Pushboom imaging systems are frequently used in industry sorting, such a system collects columns of an image one after another in a sequential manner (see Figure 1). It is thus necessary to design a framework for online classification tasks and accommodate convectional algorithms to the sequential processing setting.
Sequential hyperspectral data collecting and processing by a pushboom system. Hyperspectral camera captures data
In this chapter, we present a scheme of sequential classification for hyperspectral sorting systems. This scheme can be used in various fields, such as measuring food quality and resource recovery. We present the main techniques in this sorting and processing, including data normalization, dimension reduction, classification, and spatial information integration and the way to accommodate these techniques to the context of sequential data collecting and processing.
The rest of this chapter is organized as follows. In Section 2, we propose the main steps of sequential hyperspectral classification processing system. In Section 3, detailed methods are presented for sequential hyperspectral image processing and sorting. Experiment results are then discussed in Section 4. Section 5 concludes the chapter.
Before proceeding to elaborate the proposed sequential hyperspectral image classification method, we first present the notation and the data model used in this work. We consider that the hyperspectral image under study has
The data collecting and processing of a real-time hyperspectral sorting system consist of the following major steps.
Sequential image acquisition.
Data preprocessing.
Material classification.
The hyperspectral data used in this work set are collected by the system of GaiaField in our laboratory. The parameters of the used system are provided in Table 1. Our online processing is based on windowed columns. After collecting each column, we use this column with several previous ones to form a window and perform data processing steps within this window. Black-white normalization is used for basic data normalization. Techniques of PCA and hyperspectral decorrelation of fuzzy sets are used for dimension reduction [10]. Typical techniques such as GML and SVM are presented for material classification. Considering the positive effect of spatial information on processing results [11], we also propose to integrate spatial dimension and spectral dimension to achieve an enhanced classification accuracy. Finally, classification accuracy is characterized by metrics such as confusion matrix and κ coefficient. Details of the used techniques and results will be provided later.
Equipment type | GaiaField and GaiaSorter |
---|---|
Moving speed of loading platform | 4.1 cm/s |
Spectral resolution | 128 |
Spatial resolution | |
Distance between lens and samples | 24 cm |
Exposure time | 3 ms |
Equipment parameters.
Data preprocessing steps include basic data normalization and spectral decorrelation. They are performed one after another as described later.
An important preprocessing is the so-called black-white calibration. This calibration is carried out by recording an image for black and another for white, as described below, to remove the effect of dark current of the camera sensor and avoid the uneven light intensity of each band. At an offline phase, the black image (
where
The high-spectral resolution of hyperspectral data enables us to classify materials that are undistinguishable with conventional methods. However, a large number of spectral channels result in difficulties in processing in terms of classifier training (Hughes phenomenon) and computational burdens. Data dimension reduction can be performed due to the above facts and existence of information redundancies across bands.
PCA is one of the most popular methods for data dimension reduction. PCA computes a linear transformation for high-dimensional input vectors, and this transformation maps the data into a low-dimensional orthogonal subspace. For simplicity, we assume that the data samples have zero mean. Otherwise, we can centralize the data by subtracting the mean
The principle analysis is based on the eigenstructure of the data. We therefore calculate the covariance matrix of
To reduce the dimension of data, we select an appropriate number of eigenvectors
where
Using fuzzy sets to decorrelate the hyperspectral data is based on a priori knowledge that the adjacent wavelengths of the spectrum are more correlated than the distant pairs, as the spectral information varies smoothly and successively. We consider sampling spectral characteristics by a group of adjacent spectral bands, which can be obtained by dividing the spectra in separate groups to attain the desired spectral selectivity. We propose separating the hyperspectral data into a number of
where
Triangular function.
The spectral wavelengths of all points have different membership degrees in different fuzzy sets. Each wavelength has different degree of membership in two adjacent fuzzy sets, while the membership degree in the remaining fuzzy sets is 0 (Figure 3).
Triangular function weighted process.
The energy of each fuzzy set is calculated by weighting the intensity of each spectrum element using membership functions associated with each fuzzy set, i.e.,
where
Based on the energy values of each fuzzy set, we can obtain useful information about the spectral characteristics. In this way, each hyperspectral image pixel can be defined by a vector containing the energy values of the
In this section, we present the algorithm to classifier/sort the captured data using features (data of reduced dimension) extracted by PCA or fuzzy set method. We first review these two popular classification methods in a general manner. Then we introduce how to incorporate spatial information into the classification. Finally, sequential processing with window-based method will be discussed.
Spectra of distinct material of hyperspectral data form data clusters in a space with the dimension of the feature, and we assume that the data features of each material approximately follow a multivariate normal distribution. To be specific, data features of a material
where
SVM is one of the most effectively and widely used methods in statistical learning. SVM aims to find the best tradeoff of model complexity and learning ability with limited sample information. SVM can effectively solve the Hughes phenomenon caused by insufficient samples in hyperspectral classification.
The goal of training algorithm is to design an optimal hyperplane. The training principle of SVM is to find a linear optimal separating hyperplane [16]. Let
This method constructs a hyperplane that maximizes the margins between classes, specified by a (usually small) subset of the data that define the position of the separator. These points are referred to as the support vectors [17]. The decision function is as follow:
where
Sometimes, data cannot be separated by a linear classifier. Therefore, kernel methods are used to map data from the original input space to a higher dimension space. Thanks to the kernel trick, we only need to know the form of the inner product in that space instead of using the explicit map [16]. Popular kernel functions include as follows:
Linear kernel:
Polynomial kernel:
where
Radial basis function kernel:
where
Sigmoid kernel:
for appropriate values of
Conventionally, hyperspectral data classification algorithms are proposed based on spectroscopic viewpoint, and they ignore the spatial information that embeds in neighboring pixels [18]. Integration of spatial and spectral information may improve the processing performance. We propose to combine spatial dimension and spectral dimension information to improve the classification accuracy. The proposed method investigates the spatial information based on the connection component labeling in the following. We generate the mean image by averaging data after dimension reduction over spectra bands. A component labeling algorithms then applied to the binarized mean image. In our system, if an object is marked by connected component labeling and over 60% pixels are labeled as a class, we consider that all pixels within this connected region actually belong to the associated material. The classification accuracy will be improved using this strategy.
We use a sliding window to assemble the acquired hyperspectral data, whose columns are collected sequentially one after another. The use of a sliding window facilitates to incorporate the spatial information in processing. The width of the sliding window should be determined by considering the data acquisition rate, data processing speed, and spatial correlation of the observed scenario. In our system, the width of the sliding window (
Sliding window.
We collect the hyperspectral data with our pushboom system of Gaia. The images are acquired in the 400–1000 nm wavelength range, with a spectral resolution of 7 nm, for a total of 128 wavelengths (
After data preprocessing, we select 300 pixels of each material from the training set as sample points to form a hyperspectral image. The pixels of the image are converted into row vectors by row or column to form a two-dimensional matrix, which is used for data reduction. The operation of the test set is the same as that of the training set.
After the PCA transformation, the eigenvalue distribution is shown in Figure 5. This scree plot shows that the first eight factors explain most of the variability. The remaining factors explain a very small proportion of the variability and are likely unimportant. We select the principal component, which takes 99% of the eigenvalues, as the data after dimensionality reduction. For fuzzy-set data reduction, we fold 128 bands with a triangular window of length 32, and then we sample the data using at each 16 points, so that the data dimension also reduces to 8. We use eight-connected component labeling method to remove the background of data after dimension reduction.
Eigenvalue distribution.
We then study the classification results of GML principle and SVM. We classify the data obtained from dimension reduction and background material removal (see Figures 6 and 7). The result of classification with spatial information (connected region labeling) is shown in Figure 8.
(a) GML classification with PCA and (b) GML classification with fuzzy sets.
(a) SVM classification with PCA and (b) SVM classification with fuzzy sets.
Classification with spatial information (connected region labeling) achieves almost 100% accuracy.
A confusion matrix is a table that is often used to describe the performance of a classifier on a set of test data for which the true values are known. It compares the classification result with the reference image, and we need to determine the labels of each point in the reference image in the classified image. The confusion matrixes of our experiment are shown in Table 2.
Class | Actual class | |||||
---|---|---|---|---|---|---|
Chinese date | Lemon | Orange | Tomato | Row sum | ||
(1) GML classification with PCA | ||||||
Predict class | Chinese date | 1745 | 0 | 0 | 0 | 1745 |
Lemon | 4 | 9618 | 0 | 0 | 9622 | |
Orange | 0 | 183 | 11,654 | 0 | 11,837 | |
Tomato | 26 | 14 | 0 | 7359 | 7399 | |
Column sum | 1775 | 9815 | 11,654 | 7359 | 30,603 | |
(2) GML classification with fuzzy sets | ||||||
Predict class | Chinese date | 1745 | 0 | 0 | 0 | 1745 |
Lemon | 3 | 9619 | 0 | 0 | 9622 | |
Orange | 258 | 2 | 11,577 | 0 | 11,837 | |
Tomato | 36 | 7 | 0 | 7356 | 7399 | |
Column sum | 2042 | 9628 | 11,577 | 7356 | 30,603 | |
(3) SVM classification with PCA | ||||||
Predict class | Chinese date | 1744 | 1 | 0 | 0 | 1745 |
Lemon | 6 | 9616 | 0 | 0 | 9622 | |
Orange | 466 | 1089 | 10,282 | 0 | 11,837 | |
Tomato | 29 | 0 | 0 | 7370 | 7399 | |
Column sum | 2245 | 10,706 | 10,282 | 7370 | 30,603 | |
(4) SVM classification with fuzzy sets | ||||||
Predict class | Chinese date | 1738 | 0 | 0 | 7 | 1745 |
Lemon | 5 | 9617 | 0 | 0 | 9622 | |
Orange | 1489 | 2826 | 7522 | 0 | 11,837 | |
Tomato | 28 | 1144 | 0 | 6227 | 7399 | |
Column sum | 3260 | 13,587 | 7522 | 6234 | 30,603 |
Confusion matrix of classification results: (1) GML classification with PCA, (2) GML classification with fuzzy sets, (3) SVM classification with PCA, and (4) SVM classification with fuzzy sets.
where
(a) Confusion matrix of GML classification with PCA and (b) confusion matrix of GML classification with fuzzy sets.
(a) Confusion matrix of SVM classification with fuzzy sets and (b) confusion matrix of SVM classification with fuzzy sets.
κ can reflect the classification error of the whole image and solve the problem that the classification accuracy depends too much on the number of classes and the number of samples. κ is performed by adopting the following equation:
where
κ of GML based on PCA dimensionality reduction is 98.93%, and κ of SVM is 92.55%. κ of GML based on fuzzy-set reduction technique is 98.56%, and κ of SVM is 74.69%. From the results of κ, we can see that the classification based on PCA is better than fuzzy sets, GML is better than SVM, and GML based on PCA is the best method for sequential classification of hyperspectral images.
Other metrics include classification accuracy, product’s accuracy (PA), and omission errors (OEs).
Classification accuracy indicates the correct rate of the classifier, as illustrated in Eq. (16).
PA is used to indicate the rate of the classification result that is correctly classified, as illustrated in Eq. (17). User’s accuracy is used to indicate the rate of the pixels that are correctly divided into class
OEs represent the number of pixels in class
Classification accuracy of GML based on PCA dimensionality reduction is 99.26%, and classification accuracy of SVM is 94.80%. Classification accuracy of GML based on fuzzy-set reduction technique is 99.00%, and classification accuracy of SVM is 82.03%. From this evaluation and Table 3, GML based on PCA dimensionality reduction is the proposed solution for sequential classification of hyperspectral images.
Other metrics | Chinese date | Lemon | Orange | Tomato |
---|---|---|---|---|
(1) GML classification with PCA | ||||
0.9831 | 0.9799 | 1 | 1 | |
0.0169 | 0.0201 | 0 | 0 | |
1 | 0.9996 | 0.9845 | 0.9946 | |
0 | 0.0004 | 0.0155 | 0.054 | |
(2) GML classification with fuzzy sets | ||||
0.8546 | 0.9991 | 1 | 1 | |
0.1454 | 0.0009 | 0 | 0 | |
1 | 0.9997 | 0.9780 | 0.9941 | |
0 | 0.0003 | 0.0220 | 0.0059 | |
(3) SVM classification with PCA | ||||
0.7768 | 0.8982 | 1 | 1 | |
0.2232 | 0.1018 | 0 | 0 | |
1 | 0.9994 | 0.8686 | 0.9961 | |
0 | 0.0006 | 0.1314 | 0.0039 | |
(4) SVM classification with fuzzy sets | ||||
0.5331 | 0.7078 | 1 | 0.9989 | |
0.4669 | 0.2922 | 0 | 0.0011 | |
0.9960 | 0.9995 | 0.6355 | 0.8416 | |
0.0040 | 0.0005 | 0.3645 | 0.1584 |
Other metrics: (1) GML classification with PCA, (2) GML classification with fuzzy sets, (3) SVM classification with PCA, and (4) SVM classification with fuzzy sets.
The major objective of this chapter is to build a sequential hyperspectral classification method for an industrial material sorting system. We propose hyperspectral images captured by a pushboom system where columns of images are collected sequentially one after another to get sequential hyperspectral images. PCA and fuzzy sets are used for data decorrelation. We study the GML and SVM classification with the data obtained from dimension reduction and background material removal and carry out the performance analysis. The results show that the accuracy rate of GML based on PCA dimensionality reduction is 99.26%, and the accuracy rate of SVM is 94.80%. The accuracy of GML based on fuzzy-set reduction technique is 99.00%, and the accuracy rate of SVM is 82.03%. After combing the spatial and spectral information, the accuracy of classification of hyperspectral images can be 100%.
The designed framework shows several advantages in terms of processing speed, efficiency, and accuracy. It may play an important role in industrial material sorting for agricultural products, food, and industrial waste sorting.
This work was supported in part by National Natural Science Foundation of China under grant 61671382 and in part by National Natural Science Foundation of Shenzhen under grant JCYJ2017030155315873.
Vascular smooth muscle cells wrapping around small resistance arteries and arterioles are crucial for vascular reactivity [1]. These cells enable dynamic, moment-to-moment control of vessel diameter and pressure-induced contraction (e.g., vascular tone). This control is central to autoregulation of resistance vessels, maintenance of vessel caliber independently of changes in blood pressure, and proper perfusion to meet the metabolic demands of a given tissue.
To regulate arterial diameter, vascular smooth muscle receives and integrates many inputs, including changes in intraluminal pressure, vasoconstrictor and vasodilatory signals from endothelial cells lining the inner arterial wall, and nerve terminals innervating the vessels [2]. These inputs regulate vascular smooth muscle excitability, at least in part, by modulating the activity of a number of ion channels to control membrane potential (Em) and the magnitude of intracellular Ca2+ concentration ([Ca2+]i) [1]. Among the many ion channels, transient receptor potential (TRP) channels, voltage-gated (KV), Ca2+-activated (BKCa) and inward rectifier (Kir) K+ channels, and voltage-gated Ca2+ channels (VGCC) are fundamental in transducing mechanical force, establishing Em, and regulating [Ca2+]i [1]. Mechanisms for the regulation of vascular smooth muscle ion channels, including those mentioned above, involve agonist-independent and agonist-dependent activation of Gq and/or Gs protein-coupled receptors (GxPCR) [3]. The optimal activation and regulation of these mechanisms are often dependent on the formation of macromolecular complexes driven by scaffold proteins to target and compartmentalize proteins/signaling events to specific regions and substrates [4].
In this chapter, we provide a brief overview of our current understanding of the role of different subunits of TRP channels, several K+ channel subtypes, as well as key VGCCs in control of vascular smooth muscle excitability and (micro)vascular function. We will also discuss their regulation by signaling pathways and macromolecular complexes. Note that many more studies than those cited here can be found in the scientific literature. Comprehensive studies exploring additional aspects of vascular ion channel regulation, vascular smooth muscle excitability, and (micro)vascular function in health and disease can be found in recent reviews [1, 5, 6, 7, 8, 9].
The TRP channel superfamily is composed of 28 members divided into 6 subfamilies based on their molecular and biophysical properties [10]. Functional TRP channels are composed of four subunits, each with six membrane-spanning helices that can exist in a homomeric or heteromeric form. Vascular smooth muscle cells express a number of these channels, including members of the TRPC, TRPV, TRPM, and TRPP subfamilies [7, 9]. The function of TRP channels in vascular smooth muscle ranges from regulating contractility to modulating the proliferative state of the cells. In this section, we focused our discussion on the functional role and regulation of specific TRP channels in vascular smooth muscle excitability.
The function of different TRP channels in vascular smooth muscle has been unmasked using conventional and innovative molecular, pharmacological, and genetic approaches. These approaches revealed distinctive roles of specific TRP channel subfamilies in modulating vascular smooth muscle excitability and vascular reactivity. For instance, studies have found that TRPC3 channels are not essential for pressure-induced constriction. Yet, TRPC3 channels play a key role in receptor-mediated vasoconstriction of resistance arteries upon activation of various GqPCRs, including purinergic receptors, endothelin (ETA) receptors, and angiotensin II (AT1) receptors [7, 11, 12]. The mechanisms for TRPC3 channel activation involve direct coupling of the channel with IP3 receptors located in the sarcoplasmic reticulum (SR) in a process that does not require SR Ca2+ release [13]. TRPC5 channels, in association with TRPC1 channels, have been shown to contribute to store-operated Ca2+ entry in vascular smooth muscle from arterioles [14], which may modulate cell excitability. Expression of TRPP channels in vascular smooth muscle contributes to stretch-activated cation currents, which causes vascular smooth muscle membrane depolarization. The activity of these channels has been associated with stretch-dependent regulation of vascular tone in cerebral arteries and control of systemic blood pressure [15, 16]. The nonselective cation channel TRPC6 is involved in Ca2+ mobilization leading to vascular smooth muscle contraction [17]. More recently, these channels have been shown to be part of a mechanosensation complex [18]. In this model (see Figure 1), stretch is “sensed” by AT1 receptors. These receptors then induce the activation of TRPC6 channels to bolster Ca2+ release from the SR, which triggers TRPM4 channel activity and vascular smooth muscle contraction. This model reveals an exquisite and finely orchestrated macromolecular complex for control of stretch-induced contraction.
Regulation of vascular smooth muscle excitability by TRP channels. Diverse TRP channels contribute to vascular smooth muscle relaxation or contraction. Ca2+ influx via TRPV4 channels is associated with an increase in the frequency of Ca2+ release through ryanodine receptors (RyR) located in the sarcoplasmic reticulum (e.g., Ca2+ sparks). The production of Ca2+ sparks triggers the activity of adjacent BKCa channels at the surface membrane to promote K+ efflux, membrane potential hyperpolarization, and vascular smooth muscle relaxation [
Contrary to the contractile influences of the TRP channels described above, activation of TRPV4 channels is associated with vascular smooth muscle relaxation (Figure 1) [19]. The underlying mechanism involves the formation of a macromolecular complex between TRPV4 and BKCa channels in the plasma membrane and ryanodine receptors (RyR) in the SR. This complex does not depend on direct protein-protein interactions between TRPV4 and BKCa channels and RyR but requires their close physical proximity. The close association between these proteins facilitates Ca2+ influx via TRPV4 channels that stimulates RyR activity resulting in the generation of Ca2+ sparks. The ensuing Ca2+ sparks activate BKCa channels leading to vascular smooth muscle membrane potential hyperpolarization and relaxation [20]. Because of the high Ca2+ permeability of TRPV4 channels in vascular smooth muscle [21], they could potentially activate adjacent BKCa channels directly to regulate cell excitability and vascular reactivity. Examination of this exciting possibility is an excellent opportunity for further research. Moreover, additional work is needed to comprehensively define the role of TRP channels in vascular smooth muscle in the microcirculation during physiological and pathological conditions.
It has been well documented that agonist-dependent activation of GqPCRs/protein kinase C (PKC) and GsPCRs/protein kinase A (PKA) signaling regulates TRP channels [10]. Protein kinase G (PKG) modulation of TRP channels has also been reported. However, how these signaling pathways control TRP channel activity in vascular smooth muscle, as well as the underlying consequences in vascular reactivity are not well understood. A limited number of studies have shown that PKG inhibits TRPC3 channels and that this may contribute to nitric oxide (NO)-mediated relaxation, but the mechanisms require further examination [22]. PKA signaling stimulates the activity of several members of the TRPV channel subfamily while inhibiting TRPC5 and TRPC6 channels in vascular smooth muscle [7]. PKA-mediated inhibition of TRPC6 channels in response to agonist stimulation was shown to be dependent on phosphorylation of the TRPC6 subunit at threonine 69, which resulted in a reduction in angiotensin II (angII)-induced vasoconstriction [23], thus revealing a comprehensive mechanism for the regulation of TRP channels and the underlying effects in vascular reactivity.
PKC activity inhibits TRPC3 channels and activates TRPM4 and TRPV4 channels in smooth muscle [7, 9, 21, 24]. TRPM4 activation by PKC proceeds, at least in part, by stimulating channel trafficking and membrane translocation via a mechanism requiring PKCδ [25]. This PKCδ-dependent anterograde TRPM4 trafficking is functionally relevant as it promotes vascular smooth muscle contraction. PKC-dependent regulation of TRPV4 channels has been suggested to be critical for counteracting the vasoconstriction stimulated by angII [21]. Intriguingly, TRPV4 channels are found in complex with the scaffold A kinase anchoring protein 5 (AKAP5 = human AKAP79 and murine AKAP150) in vascular smooth muscle (Figure 1) [21, 26]. This scaffold protein provides a platform for targeting and compartmentalization of signaling molecules (e.g., PKA, PKC, protein phosphatase 2B = PP2B) to specific substrates (e.g., ion channels) [4]. With a suggested distance between them of ~200 nm [26], optimal AKAP5-anchored PKC modulation of TRPV4 activity is highly dependent on the distance between the targeted kinase and the ion channel. This tight regulation of TRPV4 activity by AKAP5 may be essential for vascular smooth muscle excitability given the high Ca2+ permeability of these channels, as mentioned previously. Mechanisms regulating TRPP channels by PKA and/or PKC in vascular smooth muscle are currently unclear. The studies discussed above reveal the complex functional role of TRP channels in vascular smooth muscle and how their regulation alters vascular function and highlights unique opportunities for further research. For instance, it will be important to define the role of the AKAP5/PKC/PKA complex and its association with other TRP channels in regulating vascular smooth muscle excitability and vascular reactivity. It also remains to be determined whether dynamic trafficking of other TRP channels and the involvement of the AKAP5/PKC/PKA complex in this process also play a role in fine-tuning vascular reactivity.
The activity of K+ channels determines vascular smooth muscle membrane potential and is therefore key regulators of vascular tone [1]. By setting and controlling the membrane potential, these channels influence the levels of [Ca2+]i and therefore, vascular smooth muscle contraction. Intriguingly, a subset of K+ channels has also been linked to regulation of vascular smooth muscle proliferation (see recent review on this topic in [27, 28]). Vascular smooth muscle cells express a wide variety of isoforms from several classes of K+ channels, including KV, BKCa, and Kir channels (see Figure 2). In the following sections, we will describe the expression, function, and regulation of these K+ channels and their control of vascular function.
Regulation of vascular smooth muscle excitability by K+
A number of KV channels isoforms are expressed in vascular smooth muscle, including members of the KV1 (KV1.1, KV1.2, KV1.3, KV1.5, KV1.6), KV2 (KV2.1), and KV 7 (KV7.1–5), as well as several silent KV subunits (e.g., KV9.3) [1]. KV channels are formed by a homo- or heterotetrameric assembly of pore-forming α subunits and regulatory β subunits. Key examples with functional relevance in vascular smooth muscle excitability from multiple vascular beds are KV channels assembled by KV1.2/KV1.5 subunits, KV2.1 subunits with KV9.3, and KV1/KV7 subunits. These subunit compositions confer functional and pharmacological diversity essential for fine-tuning vascular smooth muscle excitability and vascular reactivity [29, 30, 31]. The mechanisms for this involve activation of KV channels by a depolarizing stimulus (e.g., stretch-induced depolarization) and their regulation by vasoactive agents [1, 32, 33]. The resultant K+ efflux hyperpolarizes the membrane potential of vascular smooth muscle leading to a decrease in the open probability of voltage-gated L-type Ca2+ channels CaV1.2 (LTCCs), which contributes to decrease [Ca2+]i and relaxation (Figure 2). Conversely, their inhibition depolarizes the membrane potential, which will increase the open probability of LTCCs and lead to an increase in global [Ca2+]i and vascular smooth muscle contraction. This negative feedback regulation, together with other K+ channels, is essential for fine control of vascular smooth muscle excitability and vascular reactivity. However, in the context of the microcirculation, not much is known regarding the expression, functional composition, physiological role, and regulation of KV channels in arteriolar vascular smooth muscle. Consideration of these issues is important as recent studies have implicated that impairment in KV channel expression and/or function in the development of channelopathies are associated with small vessel diseases [34]. Moreover, additional pathologies such as hypertension, metabolic disorders, and diabetic hyperglycemia impair (micro)vascular function, at least in part, by altering the expression/function of KV channels, but mechanisms remain not fully understood (see review in [5]).
Many vasoactive agents modulate vascular function by acting on KV channels expressed in vascular smooth muscle. For instance, agents that trigger activation of GqPCRs, such as angII, phenylephrine, and endothelin 1, are known to stimulate vasoconstriction, at least in part, by decreasing the expression and/or function of KV channels, particularly those of the KV1, KV2, and KV7 subfamilies (Figure 2) [1, 35, 36, 37]. The effects of these vasoconstrictors are related to PKC-mediated phosphorylation and/or changes in surface expression of KV subunits [36, 38, 39, 40], perhaps via engagement of different PKC isoforms [41]. This may contribute to selective control of KV channel activity in response to different stimuli. In addition, increases in [Ca2+]i have also been associated with inhibition of KV channels [42, 43]. Considering that activation of GqPCRs also increases [Ca2+]i, these data suggest that both PKC activity and elevated [Ca2+]i could synergize to exacerbate KV channel inhibition, which will result in membrane potential depolarization, activation of LTCCs, and vascular smooth muscle contraction.
In stark contrast to Gq signaling, activation of NO/PKG and Gs/PKA signaling is typically associated with stimulation of vascular KV channels, including the members of the KV1 and KV7 subfamilies [1]. The functional consequence of this regulation is vascular smooth muscle relaxation. Phosphorylation of KV channels by PKA is opposed by protein phosphatases such as PP2B, which will dephosphorylate the different subunits [44]. Whether GsPCR/PKA/PP2B regulation of KV channels requires scaffolding proteins that could target all components of the signaling complex within close proximity to the channels is not well understood. A recent series of studies have demonstrated that the scaffold protein postsynaptic density 95 (PSD95), which was thought to be a neuronal-specific protein, is expressed in vascular smooth muscle (Figure 2) [45, 46]. Intriguingly, PSD95 was found to be necessary for basal- and isoproterenol-induced PKA-mediated activation of KV1.X channels that resulted in vascular smooth muscle relaxation [45, 46, 47]. This was due to the formation of a distinctive PSD95-mediated signaling complex involving the β1-adrenergic receptor (β1 AR)-, PKA-, and KV1.2-containing channels [45, 47]. Since PSD95 is associated with AKAP5 in neurons [48], the argument was made that the PSD95-AKAP5 complex may be essential for PKA targeting and regulation of KV1.2 function and that this will have an impact on vascular smooth muscle excitability and vascular reactivity [47]. However, additional studies have found that K+ currents produced by KV1.X and KV2.X subunits and BKCa channels are of similar magnitude in wild-type and AKAP5-depleted (AKAP5−/−) vascular smooth muscle cells [5, 49, 50]. These results suggest that, at least basally, AKAP5 is not necessary, and PSD95 may be sufficient for PKA-dependent regulation of K+ channels in these cells. β-Adrenergic stimulation has also been found to regulate KV7 channels leading to vasorelaxation [51], but whether a scaffold protein is mediating these effects is unknown and thus requires further examination. In addition, it is also unclear how KV2-containing channels, which contribute about 70% of the KV current in mouse cerebral and mesenteric vascular smooth muscle [49], are regulated by PKA signaling, presenting another area of further research.
BKCa channels are abundantly expressed in vascular smooth muscle cells [52]. The pore-forming α subunit (BKCa α1.1) assembles into tetramers to form a functional channel, but unlike TRP and KV subunits, it contains seven transmembrane domains and a heavily regulated long carboxyl terminal. Further regulation of BKCa channel function is conferred by the association of the α subunit with accessory β1 and LRRC26 γ subunits, which increases the Ca2+ sensitivity of the channel [52]. BKCa channels are sensitive to voltage and Ca2+. The Ca2+ source to activate BKCa channels comes from the release of Ca2+ from the SR via RyRs (Figure 2) [20]. This complex does not depend on direct protein-protein interactions between BKCa channels and RyR but requires that both of these ion channels are in close physical proximity to each other. As mentioned above, data also have suggested that TRPV4 is responsible for triggering RyR activity [19], and thus, these channels have been proposed to form part of the same signaling complex with BKCa and RyRs in vascular smooth muscle. Intriguingly, LTCCs have been found to have an indirect or “loose” coupling with RyRs that could enable their activation [53], perhaps by modulating the SR Ca2+ concentration [54]. Additional components of the same or similar signaling complexes (see T-type Ca2+ channels section) with divergent roles have been identified [1, 7, 13, 55], but an integrated model remains to be defined. Regardless, the activation of these channels should result in K+ efflux that hyperpolarizes the plasma membrane of vascular smooth muscle cells leading to relaxation. The physiological influence of BKCa channels in control of membrane potential and vascular tone, however, seems to be species-, stimulus-, and vessel-dependent, even when compared between different orders of the same vascular tree. Indeed, studies have reported a clear involvement of BKCa channels in tonic negative feedback regulation of membrane potential and pressure-induced constriction, even in human resistance arteries, whereas others have failed to establish a relationship (exemplary studies in [56, 57, 58, 59, 60, 61, 62]). The differences may be associated with disparities in the BKCa channel’s Ca2+ sensitivity and/or subunit expression levels and composition in the different vascular beds. A recent and broader discussion on this topic can be found in [1]. Thus, given the distinctive role of BKCa channels in the vasculature, further research on how these channels are regulated to control vascular tone in different vascular beds during physiological and pathological conditions is warranted.
Generally, vasoactive agents that act via activation of the Gs/adenylyl cyclase (AC)/PKA and NO/soluble guanylyl cyclase (sGC)/PKG axes potentiate BKCa channel activity, whereas those acting through the Gq/phospholipase C (PLC)/PKC axis inhibit the channel [1, 52]. Vasoactive agents may also regulate BKCa channel activity indirectly by modulating the function of RyR in the SR or other ion channels (e.g., L-type CaV1.2 and T-type CaV3.2 channels) in the plasma membrane that are involved with direct activation of RyR or SR Ca2+ refilling [54, 63, 64]. Although there is some evidence that scaffold proteins such as AKAP5 may help target signaling molecules to BKCa channels [65], whether this indeed occurs in native vascular smooth muscle cells, as well as its functional relevance, is unclear. Considering the role of BKCa channels in negative feedback regulation of vascular tone, the physiological implications of vasoactive agents acting through distinct GxPCRs on BKCa channels will be either vascular smooth muscle relaxation or contraction.
As their name implies, Kir channels produce an inward current. This current is observed at a potential negative to the K+ equilibrium potential that helps stabilize the resting Em [1, 66]. They also produce a small outward current at depolarizing potentials that serves as an electrical amplifier to magnify hyperpolarization. Inward rectification occurs due to voltage-dependent blockade of the channel by polyamines and Mg2+. Kir channels are regulated by lipids (e.g., phosphatidylinositol 4,5 bisphosphate (PIP2) and cholesterol) [1, 66]. Intriguingly, a recent study found that cholesterol, but not PIP2, regulates Kir channel activity in the cerebral vascular smooth muscle [67], suggesting that these channels may be distinctively modulated by lipids depending on their tissue distribution. A functional Kir channel is formed when four pore-forming α subunits, each containing two membrane-spanning domains, come together. Two main α subunits (e.g., Kir2.1 and Kir2.2) have been identified in vascular smooth muscle from multiple species [68, 69, 70, 71]. Intriguingly, the expression of these subunits in a specific vascular bed may be species-dependent. Accordingly, although Kir subunit expression and channel activity have been extensively reported in murine cerebral vascular smooth muscle [67, 68, 69, 71], minimal, if any, Kir subunit expression and channel activity were found in the human cerebral vascular smooth muscle [72]. The functional implication of the activation of these channels in vascular smooth muscle is relaxation. Kir channel activity can be modulated by vasoactive agents with those acting through the Gq/PLC/PKC axis, inducing channel inhibition, and those acting on the Gs/AC/PKA pathway, promoting channel activity [1]. The physiological relevance of these regulatory mechanisms on Kir channels and their control of vascular function are less well understood and therefore are in need of further evaluation.
Vascular smooth muscle cells express several subtypes of VGCCs [9]. These channels have been shown to be important for vascular smooth muscle contraction, and some subtypes have been implicated in relaxation mechanisms. In this section, we will focus on the role of two key subtypes of VGCCs, namely, LTCCs and T-type Ca2+ channels (TTCCs), in regulation of vascular smooth muscle excitability.
The L-type Ca2+ channel CaV1.2 (i.e., LTCCs) is essential for vascular smooth muscle contraction and vascular reactivity. Therefore, they play a key role in controlling blood flow and blood pressure [33, 73]. LTCCs are comprised of a pore-forming α1c subunit and auxiliary β, α2δ, and γ subunits that modulate channel function and trafficking [74]. The α1c subunit contains four homologous domains (I, II, III, IV). Each domain comprises of six membrane-spanning segments (S1–S6) with intracellular amino- and carboxyl termini, which contain many regions relevant for channel regulation and control of cell excitability. In vascular smooth muscle, expression of the α1c subunit is critical for pressure-induced constriction as evidenced by an absence of myogenic response after LTCC blockade and depletion of the CaV1.2-α1c subunit in mice (e.g., SMAKO mouse) [33, 73, 75]. The auxiliary subunits α2 and δ are the product of the same gene that gets proteolytically cleaved after translation but remains connected by disulfide bonds, which give rise to the mature subunit. The α2δ subunit has been linked to regulation of α1c subunit surface expression that controls Ca2+ influx in vascular smooth muscle and the level of myogenic constriction [76]. The β subunit, which remains cytoplasmic, also contributes to the α1c subunit surface expression and channel regulation and therefore can modulate vascular smooth muscle excitability in health and disease [77, 78]. Unlike the other subunits, the expression, regulation, and function of the γ subunit in vascular smooth muscle are unclear and likely the subject of further research.
LTCCs in vascular smooth muscle are distinctively regulated by the Gs/AC/PKA, NO/sGC/PKG, and Gq/PLC/PKC axes [9, 79]. Accordingly, the NO/sGC/PKG signaling axis has been shown to inhibit vascular LTCCs [80]. This has been associated with a reduction in [Ca2+]i that may be part of the vasodilatory mechanism underlying the activation of this pathway [79]. Receptor-mediated signaling via the Gq/PLC/PKC axis typically results in potentiation of LTCC activity [9, 79, 81]. The functional effects of this Gq/PLC/PKC-mediated activation of LTCCs are vascular smooth muscle contraction and an increase in vascular tone. Intriguingly, activation of the Gs/AC/PKA axis has been shown to inhibit, activate, or produce no effect on vascular LTCC activity (Figure 3) [79]. Irrespectively of this however, PKA signaling has been generally linked with vasodilation, thus raising questions about the functional relevance, if any, of this kinase in the regulation of vascular LTCCs. Intriguingly, recent studies revealed that elevations in extracellular D-glucose (HG) potentiate LTCC activity via a Gs/AC/PKA pathway in vascular smooth muscle [82, 83, 84, 85]. This HG-induced PKA-dependent activation of LTCCs resulted in increased global [Ca2+]i and vasoconstriction, thus providing the first example of a PKA-dependent pathway underlying vascular smooth muscle contraction. Future studies should further examine the in vivo relevance of this pathway.
Regulation of vascular smooth muscle excitability by voltage-gated Ca2+ channels. Ca2+ influx via L-type Ca2+ channel CaV1.2 is essential for vascular smooth muscle contraction [
LTCC regulation by Gs/AC/PKA and Gq/PLC/PKC axes in vascular smooth muscle is mediated by AKAP5 (Figure 3) [85, 86]. The involvement of the scaffold in this regulation was initially speculated from total internal reflection fluorescence (TIRF) microscopy experiments that optically recorded the activity of single or clusters of LTCCs [87, 88]. From these experiments, it was clear that the activity and location of functional LTCCs were heterogeneous throughout the surface membrane of vascular smooth muscle cells [81, 87, 89]. Whereas some LTCCs showed stochastic activity with low Ca2+ flux and duration of events, others had persistent activity characterized by increased Ca2+ flux and events with prolonged open time that were produced by the opening of two or more channels [81, 87, 89, 90, 91]. The stochastic and persistent activity of LTCCs was modulated by membrane potential [92]. However, the occurrence of LTCCs with persistent activity is limited to specific regions of the surface membrane and has been demonstrated to be highly dependent on PKC activity and AKAP5 expression [81, 86]. The activity of phosphatases, such as PP2B, that are targeted to the channel by AKAP5, counteracts anchored kinase activity and restricts persistent LTCC activity (Figure 3) [89]. Accordingly, in vascular smooth muscle in which PKC is inhibited or cells from mice with genetically depleted PKC or AKAP5, the frequency of persistent LTCC activity is minimal [86, 87, 93]. In addition, PP2B inhibition stimulates persistent LTCC events in cells from wild type but not AKAP5−/− mice, suggesting that removing this “brake” facilitates kinase-mediated potentiation of channel activity [86, 89]. These results suggest an important role for AKAP5-anchored PKC and PP2B activity in modulating basal persistent LTCC activity. The physiological significance of these findings is underscored by data indicating that persistent LTCC events account for 50% of the total dihydropyridine-sensitive (e.g., LTCCs) Ca2+ influx at physiological membrane potentials [92], which is critical for vascular smooth muscle contractility in health and disease [82, 84, 86, 93].
T-type Ca2+ channels are formed by pore-forming α1 subunits with similar topology as that of the LTCC α1c subunit, but with no known auxiliary subunits that modulate channel function [74]. TTCCs are activated at more hyperpolarized potentials and show similar conductance with Ca2+ or Ba2+ as charge carriers. Vascular smooth muscle cells express several TTCC α1 subunits, including CaV3.1 (α1G) and CaV3.2 (α1H) [9, 94, 95, 96, 97, 98]. Intriguingly, CaV3.1, which is found in murine vascular smooth muscle, seems to be replaced by CaV3.3 (α1I) in human cells [96], suggesting that expression of TTCC α1 subunits is species-dependent. TTCCs have been shown to contribute to vascular smooth muscle excitability in several vascular beds from different species [9, 98]. However, rigorous analysis revealed that different CaV3.X subunits may have very divergent physiological responses. For instance, whereas CaV3.1 (CaV3.3) mediates low-pressure-induced constriction, CaV3.2 contributes to the negative feedback regulation of vascular tone by stimulating the RyR/BKCa axis (Figure 3) [64, 95, 96]. TTCCs can also be regulated by signaling molecules. Indeed, the NO/PKG and AC/PKA axes both inhibit vascular TTCCs [99, 100], which may have key implications in vascular smooth muscle excitability. Whether these signaling molecules are organized and targeted by scaffold proteins such as AKAPs to areas near TTCCs to fine-tune their function is unclear and therefore the subject of future studies.
Vascular smooth muscle excitability is exquisitely controlled by a repertoire of ion channels, which in themselves, are regulated by several vasoactive agents. The precise regulation of ion channels in vascular smooth muscle cells is essential for the dynamic adjustment of vascular tone necessary to maintain adequate tissue perfusion and blood pressure. Here, we have provided a brief overview of our current knowledge of key ion channels and their regulation by receptor-mediated signaling pathways that are activated by various vasoactive agents to modulate vascular smooth muscle excitability and therefore vascular tone. We focused on several TRP channels, multiple K+ channel subtypes, and various classes of VGCCs. We emphasized ion channel regulation by signaling pathways associated with the Gs/AC/PKA, NO/sGC/PKG, and Gq/PLC/PKC axes given their important role in modulating vascular smooth muscle excitability. When possible, we identified key gaps in knowledge, even in areas that have been extensively studied, which are fertile ground for further research. Because of the importance of all the ion channels and signaling pathways discussed above on vascular control, understanding how they are affected during pathological conditions is essential for the development of rational therapies to treat (micro)vascular diseases.
We thank the members of the Navedo Lab for critically reading early versions of the manuscript. This work was supported by NIH grants R01HL098200, R01HL121059 and R01HL149127 (to MFN), T32HL086350 (to AUS), and a UC Davis Academic Federation Innovative Development Award (to MN-C).
None.
These Terms and Conditions outline the rules and regulations pertaining to the use of IntechOpen’s website www.intechopen.com and all the subdomains owned by IntechOpen located at 5 Princes Gate Court, London, SW7 2QJ, United Kingdom.
',metaTitle:"Terms and Conditions",metaDescription:"These terms and conditions outline the rules and regulations for the use of IntechOpen Website at https://intechopen.com and all its subdomains owned by Intech Limited located at 7th floor, 10 Lower Thames Street, London, EC3R 6AF, UK.",metaKeywords:null,canonicalURL:"/page/terms-and-conditions",contentRaw:'[{"type":"htmlEditorComponent","content":"By accessing the website at www.intechopen.com you are agreeing to be bound by these Terms of Service, all applicable laws and regulations, and agree that you are responsible for compliance with any applicable local laws. Use and/or access to this site is based on full agreement and compliance of these Terms. All materials contained on this website are protected by applicable copyright and trademark laws.
\\n\\nThe following terminology applies to these Terms and Conditions, Privacy Statement, Disclaimer Notice, and any or all Agreements:
\\n\\n“Client”, “Customer”, “You” and “Your” refers to you, the person accessing this website and accepting the Company’s Terms and Conditions;
\\n\\n“The Company”, “Ourselves”, “We”, “Our” and “Us”, refers to our Company, IntechOpen;
\\n\\n“Party”, “Parties”, or “Us”, refers to both the Client and ourselves, or either the Client or ourselves.
\\n\\nAll Terms refer to the offer, acceptance, and consideration of payment necessary to provide assistance to the Client in the most appropriate manner, whether by formal meetings of a fixed duration, or by any other agreed means, for the express purpose of meeting the Client’s needs in respect of provision of the Company’s stated services/products, and in accordance with, and subject to, the prevailing laws of the United Kingdom.
\\n\\nAny use of the above terminology, or other words in the singular, plural, capitalization and/or he/she or they, are taken as interchangeable.
\\n\\nUnless otherwise stated, IntechOpen and/or its licensors own the intellectual property rights for all materials on www.intechopen.com. All intellectual property rights are reserved. You may view, download, share, link and print pages from www.intechopen.com for your own personal use, subject to the restrictions set out in these Terms and Conditions.
\\n\\nWe employ the use of cookies. By using the IntechOpen website you consent to the use of cookies in accordance with IntechOpen’s Privacy Policy. Most modern day interactive websites use cookies to enable the retrieval of user details for each visit. On our site, cookies are predominantly used to enable functionality and ease of use for those visiting the site.
\\n\\nIn no circumstances shall IntechOpen or its suppliers be liable for any damages (including, without limitation, damages for loss of data or profit, or due to business interruption) arising out of the use, or inability to use, the materials on IntechOpen's websites, even if IntechOpen or an IntechOpen authorized representative has been notified orally or in writing of the possibility of such damage. Some jurisdictions do not allow limitations on implied warranties, or limitations of liability for consequential or incidental damages; consequently, these limitations may not apply to you.
\\n\\nIntechopen.com website content and services are provided on an "AS IS" and an "AS AVAILABLE" basis. Material appearing on www.intechopen.com could include minor technical, typographical, or photographic errors. IntechOpen may make changes to any material contained on its website at any time without notice.
\\n\\nIntechOpen has no formal affiliation to any external sites that link to www.intechopen.com, unless otherwise specifically stated. As such, it is not responsible for content that appears on any such sites. The inclusion of any link to IntechOpen does not imply endorsement by IntechOpen. Use of any such linked website is done solely at the user's own discretion.
\\n\\nWe reserve the right of ownership over our entire website www.intechopen.com, and all contents. By using our services, you agree to remove all links to our website immediately upon request. We also reserve the right to amend these Terms and Conditions and our linking policy at any time. By continuing to link to our website, you agree to be bound to, and abide by, these linking Terms and Conditions.
\\n\\nIf you find any link on our website, or any linked website, objectionable for any reason, please Contact Us. We will consider all requests to remove links but will have no obligation to do so.
\\n\\nWithout prior approval and express written permission, you may not create frames around our web pages or use other techniques that alter in any way the visual presentation or appearance of our website.
\\n\\nIntechOpen may revise its Terms of Service for its website at any time without notice. By using this website, you are agreeing to be bound by the current version of all Terms at the time of use.
\\n\\nThese Terms and Conditions are governed by and construed in accordance with the laws of the United Kingdom and you irrevocably submit to the exclusive jurisdiction of the courts in London, United Kingdom.
\\n\\nCroatian version of Terms and Conditions available here
\\n"}]'},components:[{type:"htmlEditorComponent",content:'By accessing the website at www.intechopen.com you are agreeing to be bound by these Terms of Service, all applicable laws and regulations, and agree that you are responsible for compliance with any applicable local laws. Use and/or access to this site is based on full agreement and compliance of these Terms. All materials contained on this website are protected by applicable copyright and trademark laws.
\n\nThe following terminology applies to these Terms and Conditions, Privacy Statement, Disclaimer Notice, and any or all Agreements:
\n\n“Client”, “Customer”, “You” and “Your” refers to you, the person accessing this website and accepting the Company’s Terms and Conditions;
\n\n“The Company”, “Ourselves”, “We”, “Our” and “Us”, refers to our Company, IntechOpen;
\n\n“Party”, “Parties”, or “Us”, refers to both the Client and ourselves, or either the Client or ourselves.
\n\nAll Terms refer to the offer, acceptance, and consideration of payment necessary to provide assistance to the Client in the most appropriate manner, whether by formal meetings of a fixed duration, or by any other agreed means, for the express purpose of meeting the Client’s needs in respect of provision of the Company’s stated services/products, and in accordance with, and subject to, the prevailing laws of the United Kingdom.
\n\nAny use of the above terminology, or other words in the singular, plural, capitalization and/or he/she or they, are taken as interchangeable.
\n\nUnless otherwise stated, IntechOpen and/or its licensors own the intellectual property rights for all materials on www.intechopen.com. All intellectual property rights are reserved. You may view, download, share, link and print pages from www.intechopen.com for your own personal use, subject to the restrictions set out in these Terms and Conditions.
\n\nWe employ the use of cookies. By using the IntechOpen website you consent to the use of cookies in accordance with IntechOpen’s Privacy Policy. Most modern day interactive websites use cookies to enable the retrieval of user details for each visit. On our site, cookies are predominantly used to enable functionality and ease of use for those visiting the site.
\n\nIn no circumstances shall IntechOpen or its suppliers be liable for any damages (including, without limitation, damages for loss of data or profit, or due to business interruption) arising out of the use, or inability to use, the materials on IntechOpen's websites, even if IntechOpen or an IntechOpen authorized representative has been notified orally or in writing of the possibility of such damage. Some jurisdictions do not allow limitations on implied warranties, or limitations of liability for consequential or incidental damages; consequently, these limitations may not apply to you.
\n\nIntechopen.com website content and services are provided on an "AS IS" and an "AS AVAILABLE" basis. Material appearing on www.intechopen.com could include minor technical, typographical, or photographic errors. IntechOpen may make changes to any material contained on its website at any time without notice.
\n\nIntechOpen has no formal affiliation to any external sites that link to www.intechopen.com, unless otherwise specifically stated. As such, it is not responsible for content that appears on any such sites. The inclusion of any link to IntechOpen does not imply endorsement by IntechOpen. Use of any such linked website is done solely at the user's own discretion.
\n\nWe reserve the right of ownership over our entire website www.intechopen.com, and all contents. By using our services, you agree to remove all links to our website immediately upon request. We also reserve the right to amend these Terms and Conditions and our linking policy at any time. By continuing to link to our website, you agree to be bound to, and abide by, these linking Terms and Conditions.
\n\nIf you find any link on our website, or any linked website, objectionable for any reason, please Contact Us. We will consider all requests to remove links but will have no obligation to do so.
\n\nWithout prior approval and express written permission, you may not create frames around our web pages or use other techniques that alter in any way the visual presentation or appearance of our website.
\n\nIntechOpen may revise its Terms of Service for its website at any time without notice. By using this website, you are agreeing to be bound by the current version of all Terms at the time of use.
\n\nThese Terms and Conditions are governed by and construed in accordance with the laws of the United Kingdom and you irrevocably submit to the exclusive jurisdiction of the courts in London, United Kingdom.
\n\nCroatian version of Terms and Conditions available here
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6669},{group:"region",caption:"Middle and South America",value:2,count:5955},{group:"region",caption:"Africa",value:3,count:2457},{group:"region",caption:"Asia",value:4,count:12710},{group:"region",caption:"Australia and Oceania",value:5,count:1016},{group:"region",caption:"Europe",value:6,count:17716}],offset:12,limit:12,total:134176},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"0",sort:"-dateEndThirdStepPublish",src:"S-T-0"},books:[{type:"book",id:"9985",title:"Geostatistics",subtitle:null,isOpenForSubmission:!0,hash:"423cb3896195a618c4acb493ce4fd23d",slug:null,bookSignature:"Prof. Jeffrey M. Yarus, Dr. Marko Maucec, Dr. Timothy C. Coburn and Associate Prof. Michael Pyrcz",coverURL:"https://cdn.intechopen.com/books/images_new/9985.jpg",editedByType:null,editors:[{id:"78011",title:"Prof.",name:"Jeffrey M.",surname:"Yarus",slug:"jeffrey-m.-yarus",fullName:"Jeffrey M. Yarus"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11856",title:"Testosterone - Functions, Uses, Deficiencies, and Substitution",subtitle:null,isOpenForSubmission:!0,hash:"8549d2b1fcd1242f85a6a70447b1db10",slug:null,bookSignature:"Associate Prof. Hirokazu Doi",coverURL:"https://cdn.intechopen.com/books/images_new/11856.jpg",editedByType:null,editors:[{id:"473383",title:"Associate Prof.",name:"Hirokazu",surname:"Doi",slug:"hirokazu-doi",fullName:"Hirokazu Doi"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12063",title:"Critical Infrastructure - Modern Approach and New Developments",subtitle:null,isOpenForSubmission:!0,hash:"a88b0006f3a58c0a60f89e06efb31102",slug:null,bookSignature:"Dr. Antonio Di Pietro and Prof. Jose Marti",coverURL:"https://cdn.intechopen.com/books/images_new/12063.jpg",editedByType:null,editors:[{id:"284589",title:"Dr.",name:"Antonio",surname:"Di Pietro",slug:"antonio-di-pietro",fullName:"Antonio Di Pietro"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12387",title:"Natural Killer Cells - Lessons and Challenges",subtitle:null,isOpenForSubmission:!0,hash:"5576cda9d50adf4e4256e47427560510",slug:null,bookSignature:"Associate Prof. Leisheng Zhang",coverURL:"https://cdn.intechopen.com/books/images_new/12387.jpg",editedByType:null,editors:[{id:"439674",title:"Associate Prof.",name:"Leisheng",surname:"Zhang",slug:"leisheng-zhang",fullName:"Leisheng Zhang"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12072",title:"Finite Element Method and Its Extensions",subtitle:null,isOpenForSubmission:!0,hash:"3b9656ca1f591fcc44f127e12a6ef28f",slug:null,bookSignature:"Prof. Mahboub Baccouch",coverURL:"https://cdn.intechopen.com/books/images_new/12072.jpg",editedByType:null,editors:[{id:"186635",title:"Prof.",name:"Mahboub",surname:"Baccouch",slug:"mahboub-baccouch",fullName:"Mahboub Baccouch"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11668",title:"Mercury Pollution",subtitle:null,isOpenForSubmission:!0,hash:"0bd111f57835089cad4a9741326dbab7",slug:null,bookSignature:"Dr. Ahmed Abdelhafez and Dr. Mohamed Abbas",coverURL:"https://cdn.intechopen.com/books/images_new/11668.jpg",editedByType:null,editors:[{id:"196849",title:"Dr.",name:"Ahmed",surname:"Abdelhafez",slug:"ahmed-abdelhafez",fullName:"Ahmed Abdelhafez"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11994",title:"MXenes - Fabrications and Applications",subtitle:null,isOpenForSubmission:!0,hash:"184e1a0c9b5e62ebb3c7ebc53103db9f",slug:null,bookSignature:"Prof. Dhanasekaran Vikraman",coverURL:"https://cdn.intechopen.com/books/images_new/11994.jpg",editedByType:null,editors:[{id:"199404",title:"Prof.",name:"Dhanasekaran",surname:"Vikraman",slug:"dhanasekaran-vikraman",fullName:"Dhanasekaran Vikraman"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12143",title:"Herbs and Spices - New Advances",subtitle:null,isOpenForSubmission:!0,hash:"dbbc40b4b09244389b52ca80dcc10768",slug:null,bookSignature:"Dr. Eva Ivanišová",coverURL:"https://cdn.intechopen.com/books/images_new/12143.jpg",editedByType:null,editors:[{id:"352448",title:"Dr.",name:"Eva",surname:"Ivanišová",slug:"eva-ivanisova",fullName:"Eva Ivanišová"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12007",title:"Updates in Volcanology - Linking Active Volcanism and the Geological Record",subtitle:null,isOpenForSubmission:!0,hash:"a55d00d84b7616824cc783586c092525",slug:null,bookSignature:"Dr. Károly Németh",coverURL:"https://cdn.intechopen.com/books/images_new/12007.jpg",editedByType:null,editors:[{id:"51162",title:"Dr.",name:"Károly",surname:"Németh",slug:"karoly-nemeth",fullName:"Károly Németh"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11447",title:"Swarm Intelligence - Recent Advances and Current Applications",subtitle:null,isOpenForSubmission:!0,hash:"f68e3c3430a74fc7a7eb97f6ea2bb42e",slug:null,bookSignature:"Dr. Marco Antonio Aceves Fernandez",coverURL:"https://cdn.intechopen.com/books/images_new/11447.jpg",editedByType:null,editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12202",title:"Sexual Violence - Issues in Prevention, Treatment, and Policy",subtitle:null,isOpenForSubmission:!0,hash:"d3d39a00095ec14f7f869ed5b5211527",slug:null,bookSignature:"Dr. Kathleen Monahan",coverURL:"https://cdn.intechopen.com/books/images_new/12202.jpg",editedByType:null,editors:[{id:"463306",title:"Dr.",name:"Kathleen",surname:"Monahan",slug:"kathleen-monahan",fullName:"Kathleen Monahan"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12307",title:"New Insights Into Dystonia",subtitle:null,isOpenForSubmission:!0,hash:"1b011946aab26d18e0f4cfa61eb4249a",slug:null,bookSignature:" Tamer Rizk",coverURL:"https://cdn.intechopen.com/books/images_new/12307.jpg",editedByType:null,editors:[{id:"170531",title:null,name:"Tamer",surname:"Rizk",slug:"tamer-rizk",fullName:"Tamer Rizk"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:38},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:13},{group:"topic",caption:"Business, Management and Economics",value:7,count:7},{group:"topic",caption:"Chemistry",value:8,count:23},{group:"topic",caption:"Computer and Information Science",value:9,count:24},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:15},{group:"topic",caption:"Engineering",value:11,count:65},{group:"topic",caption:"Environmental Sciences",value:12,count:10},{group:"topic",caption:"Immunology and Microbiology",value:13,count:16},{group:"topic",caption:"Materials Science",value:14,count:25},{group:"topic",caption:"Mathematics",value:15,count:11},{group:"topic",caption:"Medicine",value:16,count:116},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:6},{group:"topic",caption:"Neuroscience",value:18,count:4},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:9},{group:"topic",caption:"Physics",value:20,count:9},{group:"topic",caption:"Psychology",value:21,count:10},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:9},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:4}],offset:12,limit:12,total:417},popularBooks:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11012",title:"Radiopharmaceuticals",subtitle:"Current Research for Better Diagnosis and Therapy",isOpenForSubmission:!1,hash:"f9046d6f96148b285e776f384991120d",slug:"radiopharmaceuticals-current-research-for-better-diagnosis-and-therapy",bookSignature:"Farid A. Badria",coverURL:"https://cdn.intechopen.com/books/images_new/11012.jpg",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4428},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1677,editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1337,editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1309,editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:847,editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",publishedDate:"June 15th 2022",numberOfDownloads:2273,editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:591,editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:515,editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:413,editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",publishedDate:"June 8th 2022",numberOfDownloads:2194,editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:341,editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"11043",title:"Endometriosis",subtitle:"Recent Advances, New Perspectives and Treatments",isOpenForSubmission:!1,hash:"7baf1c70b11d41400bb9302ae9411ca4",slug:"endometriosis-recent-advances-new-perspectives-and-treatments",bookSignature:"Giovana Ap. Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/11043.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"185930",title:"Associate Prof.",name:"Giovana",middleName:null,surname:"Gonçalves",slug:"giovana-goncalves",fullName:"Giovana Gonçalves"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10536",title:"Campylobacter",subtitle:null,isOpenForSubmission:!1,hash:"c4b132b741dd0a2ed539b824ab63965f",slug:"campylobacter",bookSignature:"Guillermo Tellez-Isaias and Saeed El-Ashram",coverURL:"https://cdn.intechopen.com/books/images_new/10536.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"73465",title:"Dr.",name:"Guillermo",middleName:null,surname:"Téllez",slug:"guillermo-tellez",fullName:"Guillermo Téllez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10798",title:"Starch",subtitle:"Evolution and Recent Advances",isOpenForSubmission:!1,hash:"f197f6062c1574a9a90e50a369271bcf",slug:"starch-evolution-and-recent-advances",bookSignature:"Martins Ochubiojo Emeje",coverURL:"https://cdn.intechopen.com/books/images_new/10798.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11083",title:"Hazardous Waste Management",subtitle:null,isOpenForSubmission:!1,hash:"d553bd4f6f1c4b115ca69bd19faac7dc",slug:"hazardous-waste-management",bookSignature:"Rajesh Banu Jeyakumar, Kavitha Sankarapandian and Yukesh Kannah Ravi",coverURL:"https://cdn.intechopen.com/books/images_new/11083.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"218539",title:"Dr.",name:"Rajesh Banu",middleName:null,surname:"Jeyakumar",slug:"rajesh-banu-jeyakumar",fullName:"Rajesh Banu Jeyakumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10848",title:"Tribology of Machine Elements",subtitle:"Fundamentals and Applications",isOpenForSubmission:!1,hash:"3c4ca4c4692ca8d4fa749b4ae81ec1fa",slug:"tribology-of-machine-elements-fundamentals-and-applications",bookSignature:"Giuseppe Pintaude, Tiago Cousseau and Anna Rudawska",coverURL:"https://cdn.intechopen.com/books/images_new/10848.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"18347",title:"Prof.",name:"Giuseppe",middleName:null,surname:"Pintaude",slug:"giuseppe-pintaude",fullName:"Giuseppe Pintaude"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10856",title:"Crude Oil",subtitle:"New Technologies and Recent Approaches",isOpenForSubmission:!1,hash:"8d0a7ca35b3de95b295dc4eab39a087e",slug:"crude-oil-new-technologies-and-recent-approaches",bookSignature:"Manar Elsayed Abdel-Raouf and Mohamed Hasan El-Keshawy",coverURL:"https://cdn.intechopen.com/books/images_new/10856.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"102626",title:"Prof.",name:"Manar",middleName:null,surname:"Elsayed Abdel-Raouf",slug:"manar-elsayed-abdel-raouf",fullName:"Manar Elsayed Abdel-Raouf"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9625",title:"Spinocerebellar Ataxia",subtitle:"Concepts, Particularities and Generalities",isOpenForSubmission:!1,hash:"365a7025fd46eb45de2549bdd9d50b98",slug:"spinocerebellar-ataxia-concepts-particularities-and-generalities",bookSignature:"Patricia Bozzetto Ambrosi",coverURL:"https://cdn.intechopen.com/books/images_new/9625.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"221787",title:"Dr.",name:"Patricia",middleName:null,surname:"Bozzetto Ambrosi",slug:"patricia-bozzetto-ambrosi",fullName:"Patricia Bozzetto Ambrosi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10905",title:"Plant Defense Mechanisms",subtitle:null,isOpenForSubmission:!1,hash:"84ad5b27dde5f01dc76087d0fd6fa834",slug:"plant-defense-mechanisms",bookSignature:"Josphert Ngui Kimatu",coverURL:"https://cdn.intechopen.com/books/images_new/10905.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"224171",title:"Prof.",name:"Josphert N.",middleName:null,surname:"Kimatu",slug:"josphert-n.-kimatu",fullName:"Josphert N. Kimatu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10686",title:"Natural Gas",subtitle:"New Perspectives and Future Developments",isOpenForSubmission:!1,hash:"581763788a6a59e653a9d1d9b5a42d79",slug:"natural-gas-new-perspectives-and-future-developments",bookSignature:"Maryam Takht Ravanchi",coverURL:"https://cdn.intechopen.com/books/images_new/10686.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"2416",title:"Dr.",name:"Maryam",middleName:null,surname:"Takht Ravanchi",slug:"maryam-takht-ravanchi",fullName:"Maryam Takht Ravanchi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10988",title:"Railway Transport Planning and Manageme",subtitle:null,isOpenForSubmission:!1,hash:"5cb54cc53caedad9ec78372563c82e2c",slug:"railway-transport-planning-and-management",bookSignature:"Stefano de Luca, Roberta Di Pace and Chiara Fiori",coverURL:"https://cdn.intechopen.com/books/images_new/10988.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"271061",title:"Prof.",name:"Stefano",middleName:null,surname:"de Luca",slug:"stefano-de-luca",fullName:"Stefano de Luca"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"983",title:"Cardiac Electrophysiology",slug:"cardiac-electrophysiology",parent:{id:"170",title:"Cardiology and Cardiovascular Medicine",slug:"cardiology-and-cardiovascular-medicine"},numberOfBooks:17,numberOfSeries:0,numberOfAuthorsAndEditors:499,numberOfWosCitations:255,numberOfCrossrefCitations:184,numberOfDimensionsCitations:407,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"983",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"8091",title:"Autonomic Nervous System Monitoring",subtitle:"Heart Rate Variability",isOpenForSubmission:!1,hash:"98067dd53efd76b17cf31d1664f88982",slug:"autonomic-nervous-system-monitoring-heart-rate-variability",bookSignature:"Theodoros Aslanidis",coverURL:"https://cdn.intechopen.com/books/images_new/8091.jpg",editedByType:"Edited by",editors:[{id:"200252",title:"Dr.",name:"Theodoros",middleName:null,surname:"Aslanidis",slug:"theodoros-aslanidis",fullName:"Theodoros Aslanidis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7907",title:"Practical Applications of Electrocardiogram",subtitle:null,isOpenForSubmission:!1,hash:"e6ccea0e539a40209a7d3c8507108832",slug:"practical-applications-of-electrocardiogram",bookSignature:"Umashankar Lakshmanadoss",coverURL:"https://cdn.intechopen.com/books/images_new/7907.jpg",editedByType:"Edited by",editors:[{id:"13913",title:"Dr.",name:"Umashankar",middleName:null,surname:"Lakshmanadoss",slug:"umashankar-lakshmanadoss",fullName:"Umashankar Lakshmanadoss"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7049",title:"Cardiac Pacing and Monitoring",subtitle:"New Methods, Modern Devices",isOpenForSubmission:!1,hash:"52722bbabb55cb46dc08d238880f4366",slug:"cardiac-pacing-and-monitoring-new-methods-modern-devices",bookSignature:"Mart Min",coverURL:"https://cdn.intechopen.com/books/images_new/7049.jpg",editedByType:"Edited by",editors:[{id:"62780",title:"Prof.",name:"Mart",middleName:null,surname:"Min",slug:"mart-min",fullName:"Mart Min"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7445",title:"Cardiotoxicity",subtitle:null,isOpenForSubmission:!1,hash:"90d1dca21a942e95b62075a222238625",slug:"cardiotoxicity",bookSignature:"Wenyong Tan",coverURL:"https://cdn.intechopen.com/books/images_new/7445.jpg",editedByType:"Edited by",editors:[{id:"192949",title:"Dr.",name:"Wenyong",middleName:null,surname:"Tan",slug:"wenyong-tan",fullName:"Wenyong Tan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5764",title:"Interpreting Cardiac Electrograms",subtitle:"From Skin to Endocardium",isOpenForSubmission:!1,hash:"643f7c4a2e6b3307a7bcfed8f752836f",slug:"interpreting-cardiac-electrograms-from-skin-to-endocardium",bookSignature:"Kevin A. Michael",coverURL:"https://cdn.intechopen.com/books/images_new/5764.jpg",editedByType:"Edited by",editors:[{id:"61996",title:"Dr.",name:"Kevin",middleName:null,surname:"Michael",slug:"kevin-michael",fullName:"Kevin Michael"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5239",title:"Cholesterol Lowering Therapies and Drugs",subtitle:null,isOpenForSubmission:!1,hash:"c0db17451da651dc6ff8e6c13e9e177a",slug:"cholesterol-lowering-therapies-and-drugs",bookSignature:"Chunfa Huang and Carl Freter",coverURL:"https://cdn.intechopen.com/books/images_new/5239.jpg",editedByType:"Edited by",editors:[{id:"178352",title:"Dr.",name:"Chunfa",middleName:null,surname:"Huang",slug:"chunfa-huang",fullName:"Chunfa Huang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2225",title:"Current Issues and Recent Advances in Pacemaker Therapy",subtitle:null,isOpenForSubmission:!1,hash:"5ed7d1556bff8c564197efc99c15c7f7",slug:"current-issues-and-recent-advances-in-pacemaker-therapy",bookSignature:"Attila Roka",coverURL:"https://cdn.intechopen.com/books/images_new/2225.jpg",editedByType:"Edited by",editors:[{id:"63271",title:"Dr.",name:"Attila",middleName:null,surname:"Roka",slug:"attila-roka",fullName:"Attila Roka"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1734",title:"Cardiotoxicity of Oncologic Treatments",subtitle:null,isOpenForSubmission:!1,hash:"230472e71b2dd84c0a88f75165b37604",slug:"cardiotoxicity-of-oncologic-treatments",bookSignature:"Manuela Fiuza",coverURL:"https://cdn.intechopen.com/books/images_new/1734.jpg",editedByType:"Edited by",editors:[{id:"98648",title:"Prof.",name:"Manuela",middleName:null,surname:"Fiuza",slug:"manuela-fiuza",fullName:"Manuela Fiuza"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"358",title:"Advances in Electrocardiograms",subtitle:"Methods and Analysis",isOpenForSubmission:!1,hash:"a61fed85204779463e6e483483601fdf",slug:"advances-in-electrocardiograms-methods-and-analysis",bookSignature:"Richard M. Millis",coverURL:"https://cdn.intechopen.com/books/images_new/358.jpg",editedByType:"Edited by",editors:[{id:"45295",title:"PhD.",name:"Richard",middleName:"M",surname:"Millis",slug:"richard-millis",fullName:"Richard Millis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1291",title:"Advances in Electrocardiograms",subtitle:"Clinical Applications",isOpenForSubmission:!1,hash:"956bc1bdc0de1de4908abbee641a17aa",slug:"advances-in-electrocardiograms-clinical-applications",bookSignature:"Richard M. Millis",coverURL:"https://cdn.intechopen.com/books/images_new/1291.jpg",editedByType:"Edited by",editors:[{id:"45295",title:"PhD.",name:"Richard",middleName:"M",surname:"Millis",slug:"richard-millis",fullName:"Richard Millis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1302",title:"Cardiac Defibrillation",subtitle:"Prediction, Prevention and Management of Cardiovascular Arrhythmic Events",isOpenForSubmission:!1,hash:"d33e858b527f7b45ebb96885954ba3a8",slug:"cardiac-defibrillation-prediction-prevention-and-management-of-cardiovascular-arrhythmic-events",bookSignature:"Joyelle J. Harris",coverURL:"https://cdn.intechopen.com/books/images_new/1302.jpg",editedByType:"Edited by",editors:[{id:"68764",title:"Dr.",name:"Joyelle",middleName:null,surname:"Harris",slug:"joyelle-harris",fullName:"Joyelle Harris"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"331",title:"Cardiac Defibrillation",subtitle:"Mechanisms, Challenges and Implications",isOpenForSubmission:!1,hash:"90fa2e9b5ad435b6518f47da7ade1efd",slug:"cardiac-defibrillation-mechanisms-challenges-and-implications",bookSignature:"Natalia Trayanova",coverURL:"https://cdn.intechopen.com/books/images_new/331.jpg",editedByType:"Edited by",editors:[{id:"38381",title:"Dr.",name:"Natalia",middleName:null,surname:"Trayanova",slug:"natalia-trayanova",fullName:"Natalia Trayanova"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:17,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"27007",doi:"10.5772/22937",title:"Non Contact Heart Monitoring",slug:"non-contact-heart-monitoring",totalDownloads:15852,totalCrossrefCites:19,totalDimensionsCites:24,abstract:null,book:{id:"358",slug:"advances-in-electrocardiograms-methods-and-analysis",title:"Advances in Electrocardiograms",fullTitle:"Advances in Electrocardiograms - Methods and Analysis"},signatures:"Lorenzo Scalise",authors:[{id:"49866",title:"Ph.D.",name:"Lorenzo",middleName:null,surname:"Scalise",slug:"lorenzo-scalise",fullName:"Lorenzo Scalise"}]},{id:"63304",doi:"10.5772/intechopen.79588",title:"Doxorubicin-Induced Cardiotoxicity: From Mechanisms to Development of Efficient Therapy",slug:"doxorubicin-induced-cardiotoxicity-from-mechanisms-to-development-of-efficient-therapy",totalDownloads:2370,totalCrossrefCites:14,totalDimensionsCites:22,abstract:"First isolated in the early 1960s, doxorubicin (DOX) is among the most effective anticancer agents ever developed. DOX has been used mainly for the treatment of breast cancer, solid tumors in children, soft tissue sarcomas, and aggressive lymphomas. However, the use of DOX may have dose-dependent cardiotoxic effects that generate changes in myocardial structure, which can develop into severe and irreversible cardiomyopathy. Here, we describe the incidence of DOX-induced cardiotoxicity (DIC); the progress made over the past four decades in understanding the molecular mechanisms of the pathogenesis of acute and chronic DIC; the current strategies for heart protection; and the major breakthroughs and challenges in basic and clinical research to the development of efficient targeted therapy for DIC.",book:{id:"7445",slug:"cardiotoxicity",title:"Cardiotoxicity",fullTitle:"Cardiotoxicity"},signatures:"Danúbia Silva dos Santos and Regina Coeli dos Santos Goldenberg",authors:[{id:"26576",title:"Prof.",name:"Regina C.S.",middleName:null,surname:"Goldenberg",slug:"regina-c.s.-goldenberg",fullName:"Regina C.S. Goldenberg"},{id:"255926",title:"Dr.",name:"Danúbia",middleName:null,surname:"Silva Dos Santos",slug:"danubia-silva-dos-santos",fullName:"Danúbia Silva Dos Santos"}]},{id:"32612",doi:"10.5772/34692",title:"Doxorubicin-Induced Oxidative Injury of Cardiomyocytes - Do We Have Right Strategies for Prevention?",slug:"doxorubicin-induced-oxidative-injury-of-cardiomyocytes-do-we-have-right-strategies-for-prevention-",totalDownloads:3632,totalCrossrefCites:3,totalDimensionsCites:21,abstract:null,book:{id:"1734",slug:"cardiotoxicity-of-oncologic-treatments",title:"Cardiotoxicity of Oncologic Treatments",fullTitle:"Cardiotoxicity of Oncologic Treatments"},signatures:"Vukosava Milic Torres and Viktorija Dragojevic Simic",authors:[{id:"101249",title:"Dr.",name:"Vukosava",middleName:null,surname:"Milic Torres",slug:"vukosava-milic-torres",fullName:"Vukosava Milic Torres"},{id:"115381",title:"Prof.",name:"Viktorija",middleName:null,surname:"Dragojevic-Simic",slug:"viktorija-dragojevic-simic",fullName:"Viktorija Dragojevic-Simic"}]},{id:"13779",doi:"10.5772/13329",title:"Remote Monitoring in Patients with Pacemakers and Implantable Cardioverter-Defibrillators: New Perspectives for Complex Therapeutic Management",slug:"remote-monitoring-in-patients-with-pacemakers-and-implantable-cardioverter-defibrillators-new-perspe",totalDownloads:6569,totalCrossrefCites:5,totalDimensionsCites:21,abstract:null,book:{id:"23",slug:"modern-pacemakers-present-and-future",title:"Modern Pacemakers",fullTitle:"Modern Pacemakers - Present and Future"},signatures:"Axel Müller, Thomas M. Helms, Hans-Jürgen Wildau, Jörg Otto Schwab and Christian Zugck",authors:[{id:"14408",title:"Prof.",name:"Axel",middleName:null,surname:"Müller",slug:"axel-muller",fullName:"Axel Müller"},{id:"15385",title:"Prof.",name:"Thomas M.",middleName:null,surname:"Helms",slug:"thomas-m.-helms",fullName:"Thomas M. Helms"},{id:"15386",title:"Prof.",name:"Hans-Jürgen",middleName:null,surname:"Wildau",slug:"hans-jurgen-wildau",fullName:"Hans-Jürgen Wildau"},{id:"15387",title:"Prof.",name:"Jörg Otto",middleName:null,surname:"Schwab",slug:"jorg-otto-schwab",fullName:"Jörg Otto Schwab"},{id:"15388",title:"Prof.",name:"Christian",middleName:null,surname:"Zugck",slug:"christian-zugck",fullName:"Christian Zugck"}]},{id:"13786",doi:"10.5772/12965",title:"Common Pacemaker Problems: Lead and Pocket Complications",slug:"common-pacemaker-problems-lead-and-pocket-complications",totalDownloads:105921,totalCrossrefCites:1,totalDimensionsCites:20,abstract:null,book:{id:"23",slug:"modern-pacemakers-present-and-future",title:"Modern Pacemakers",fullTitle:"Modern Pacemakers - Present and Future"},signatures:"Enes Elvin Gul and Mehmet Kayrak",authors:[{id:"13568",title:"Dr.",name:"Enes Elvin",middleName:null,surname:"Gul",slug:"enes-elvin-gul",fullName:"Enes Elvin Gul"},{id:"15681",title:"Dr.",name:"Mehmet",middleName:null,surname:"Kayrak",slug:"mehmet-kayrak",fullName:"Mehmet Kayrak"}]}],mostDownloadedChaptersLast30Days:[{id:"63852",title:"Modeling Thermoregulatory Responses to Cold Environments",slug:"modeling-thermoregulatory-responses-to-cold-environments",totalDownloads:1168,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"The ability to model and simulate the rise and fall of core body temperature is of significant interest to a broad spectrum of organizations. These organizations include the military, as well as both public and private health and medical groups. To effectively use cold models, it is useful to understand the first principles of heat transfer within a given environment as well as have an understanding of the underlying physiology, including the thermoregulatory responses to various conditions and activities. The combination of both rational or first principles and empirical approaches to modeling allow for the development of practical models that can predict and simulate core body temperature changes for a given individual and ultimately provide protection from injury or death. The ability to predict these maximal potentials within complex and extreme environments is difficult. The present work outlines biomedical modeling techniques to simulate and predict cold-related injuries, and discusses current and legacy models and methods.",book:{id:"8091",slug:"autonomic-nervous-system-monitoring-heart-rate-variability",title:"Autonomic Nervous System Monitoring",fullTitle:"Autonomic Nervous System Monitoring - Heart Rate Variability"},signatures:"Adam W. Potter, David P. Looney, Xiaojiang Xu, William R. Santee and Shankar Srinivasan",authors:[{id:"262568",title:"Mr.",name:"Adam",middleName:null,surname:"Potter",slug:"adam-potter",fullName:"Adam Potter"},{id:"271096",title:"Dr.",name:"David",middleName:null,surname:"Looney",slug:"david-looney",fullName:"David Looney"},{id:"271097",title:"Dr.",name:"Xiaojiang",middleName:null,surname:"Xu",slug:"xiaojiang-xu",fullName:"Xiaojiang Xu"},{id:"271098",title:"Dr.",name:"William",middleName:null,surname:"Santee",slug:"william-santee",fullName:"William Santee"},{id:"271099",title:"Prof.",name:"Shankar",middleName:null,surname:"Srinivasan",slug:"shankar-srinivasan",fullName:"Shankar Srinivasan"}]},{id:"38326",title:"Phrenic Nerve Pacing: Current Concepts",slug:"phrenic-nerve-pacing-current-concepts",totalDownloads:6388,totalCrossrefCites:2,totalDimensionsCites:4,abstract:null,book:{id:"2225",slug:"current-issues-and-recent-advances-in-pacemaker-therapy",title:"Current Issues and Recent Advances in Pacemaker Therapy",fullTitle:"Current Issues and Recent Advances in Pacemaker Therapy"},signatures:"Jorge F. Velazco, Shekhar Ghamande and Salim Surani",authors:[{id:"15654",title:null,name:"Salim",middleName:null,surname:"Surani",slug:"salim-surani",fullName:"Salim Surani"}]},{id:"56319",title:"Pacemaker and ICD Troubleshooting",slug:"pacemaker-and-icd-troubleshooting",totalDownloads:2646,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Continuous advancements in technology and software algorithms for pacemakers and implantable cardioverter‐defibrillators (ICDs) have improved functional reliability and broadened their diagnostic capabilities. At the same time, understanding management and troubleshooting of modern devices has become increasingly complex for the device implanter. This chapter provides an overview of the underlying physics and basic principles important to pacemaker and ICD function. The second part of this chapter outlines common device problems encountered in patients with pacemakers and ICDs and provides solutions and tips for troubleshooting.",book:{id:"5764",slug:"interpreting-cardiac-electrograms-from-skin-to-endocardium",title:"Interpreting Cardiac Electrograms",fullTitle:"Interpreting Cardiac Electrograms - From Skin to Endocardium"},signatures:"Sorin Lazar, Henry Huang and Erik Wissner",authors:[{id:"198322",title:"M.D.",name:"Erik",middleName:null,surname:"Wissner",slug:"erik-wissner",fullName:"Erik Wissner"},{id:"204910",title:"Dr.",name:"Sorin",middleName:null,surname:"Lazar",slug:"sorin-lazar",fullName:"Sorin Lazar"}]},{id:"13783",title:"Electromagnetic Interference of the Pacemakers",slug:"electromagnetic-interference-of-the-pacemakers",totalDownloads:61112,totalCrossrefCites:3,totalDimensionsCites:6,abstract:null,book:{id:"23",slug:"modern-pacemakers-present-and-future",title:"Modern Pacemakers",fullTitle:"Modern Pacemakers - Present and Future"},signatures:"Umashankar Lakshmanadoss, Priya Chinnachamy and James P Daubert",authors:[{id:"13913",title:"Dr.",name:"Umashankar",middleName:null,surname:"Lakshmanadoss",slug:"umashankar-lakshmanadoss",fullName:"Umashankar Lakshmanadoss"},{id:"14368",title:"Dr.",name:"James",middleName:null,surname:"Daubert",slug:"james-daubert",fullName:"James Daubert"},{id:"27778",title:"Prof.",name:"saadia",middleName:null,surname:"Sherazi",slug:"saadia-sherazi",fullName:"saadia Sherazi"},{id:"59543",title:"Dr.",name:"Priya",middleName:null,surname:"Chinnachamy",slug:"priya-chinnachamy",fullName:"Priya Chinnachamy"}]},{id:"38327",title:"Interventional and Minimally Invasive Surgical Techniques Facilitating Cardiac Resynchronization Therapy",slug:"interventional-and-minimally-invasive-surgical-techniques-facilitating-cardiac-resynchronization-the",totalDownloads:2864,totalCrossrefCites:1,totalDimensionsCites:1,abstract:null,book:{id:"2225",slug:"current-issues-and-recent-advances-in-pacemaker-therapy",title:"Current Issues and Recent Advances in Pacemaker Therapy",fullTitle:"Current Issues and Recent Advances in Pacemaker Therapy"},signatures:"Bela Merkely, Levente Molnar and Attila Roka",authors:[{id:"19149",title:"Dr.",name:"Levente",middleName:null,surname:"Molnár",slug:"levente-molnar",fullName:"Levente Molnár"},{id:"19167",title:"Prof.",name:"Béla",middleName:null,surname:"Merkely",slug:"bela-merkely",fullName:"Béla Merkely"},{id:"63271",title:"Dr.",name:"Attila",middleName:null,surname:"Roka",slug:"attila-roka",fullName:"Attila Roka"}]}],onlineFirstChaptersFilter:{topicId:"983",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"80475",title:"CRT Past, Present, and Future Directions: Toward Intelligent Responders Selection and Optimizing Pacing Modalities",slug:"crt-past-present-and-future-directions-toward-intelligent-responders-selection-and-optimizing-pacing",totalDownloads:76,totalDimensionsCites:0,doi:"10.5772/intechopen.101608",abstract:"Congestive heart failure (CHF) is a serious health problem affecting all nations of world. Its impact is increasing with increasing individual age. Ventricular dyssynchrony is well known to contribute to pathophysiological deterioration in more than one-third of CHF subjects. The therapeutic choices of CHF witnessed long decades of stagnant periods and a relative paucity of effective treatment. The discovery of the electrical therapy that is capable of reversing ventricular dyssynchrony, in the form of cardiac resynchronization therapy (CRT), is a true revolution in the timeline of CHF management. Despite the early enthusiasm associated with CRT implantations started in 2001, we know from the last two decades’ experience that non-responders constitute to nearly 40% of all CRT patients. This chapter is devoted to reviewing the past, present and future of CRT with special attention on better intelligent detection of the electrical substrate responsive to CRT as well as optimizing the choice of CRT subjects using the latest knowledge in electrocardiographic and state-of-art imagining technologies. Novel future directions are discussed with new scientific philosophies capable of optimizing CRT. Promising new implants techniques such as endocardial pacing of the left ventricle, His bundle pacing as well as His-optimized cardiac resynchronization therapy are discussed.",book:{id:"10863",title:"Cardiac Rhythm Management - Pacing, Ablation, Devices",coverURL:"https://cdn.intechopen.com/books/images_new/10863.jpg"},signatures:"Abdullah Alabdulgader"},{id:"80392",title:"Operation of Implantable Cardiac Devices in Hyperbaric Conditions",slug:"operation-of-implantable-cardiac-devices-in-hyperbaric-conditions",totalDownloads:56,totalDimensionsCites:0,doi:"10.5772/intechopen.102659",abstract:"Implantable devices, including Implantable Cardiac Defibrillators (ICD) and Pacemakers (PM), are being seen with increasing frequency in patients wanting to conduct recreational diving or referred for Hyperbaric Oxygen Therapy (HBOT). Under hyperbaric conditions, these devices are at risk of malfunction, mostly by changes of ambient pressure. In some cases, manufacturers publish information on how their devices operate under increased pressure. Unfortunately, this is not always the case, and for other devices, someone must perform an individual risk-benefit analysis specific for single patient and his/her implanted device. In case of medical treatment, such analysis must take into account the patient’s clinical condition, the indication for HBOT, and the capability of the HBOT facility for monitoring and intervention in the chamber.",book:{id:"10863",title:"Cardiac Rhythm Management - Pacing, Ablation, Devices",coverURL:"https://cdn.intechopen.com/books/images_new/10863.jpg"},signatures:"Jacek Kot"},{id:"80290",title:"Pacemakers and Defibrillators Implantation",slug:"pacemakers-and-defibrillators-implantation",totalDownloads:70,totalDimensionsCites:0,doi:"10.5772/intechopen.101518",abstract:"Since the introduction of pacemakers and defibrillators in the 1960s, many lives have been saved. The technologies used in the development and implantation of such devices are constantly improving, making the procedures increasingly effective and safe. However, the complexity of such implantations makes it one of the most important procedures that need high levels of expertise, knowledge, and experience on the part of the entire surgery team. There is a wide range of devices used for different purposes with various features and characteristics to suit different patients. They range from single-chamber and dual-chamber pacemakers to pulse generators and biventricular pacemakers. The present review chapter seeks to elaborate on the steps of pacemakers and defibrillators implantation, starting from patient selection to post-surgery care and patient education. It outlines all necessary measures in the preoperative, intraoperative, and postoperative stages to ensure the utmost safety, prevent infection, and avoid and treat further complications. The procedures used by our team have demonstrated satisfactory results for patients with a wide variety of conditions.",book:{id:"10863",title:"Cardiac Rhythm Management - Pacing, Ablation, Devices",coverURL:"https://cdn.intechopen.com/books/images_new/10863.jpg"},signatures:"Kamran Ghods, Mohammad Forozeshfard, Shahrzad Aghaamoo, Narges Amini and Hoda Zangian"},{id:"79644",title:"Postoperative Pain Control Following Cardiac Implantable Electronic Device Implantation",slug:"postoperative-pain-control-following-cardiac-implantable-electronic-device-implantation",totalDownloads:95,totalDimensionsCites:0,doi:"10.5772/intechopen.101517",abstract:"Postoperative pain following cardiac implantable electronic device (CIED) surgery may not always be adequately treated. The postoperative pain trajectory occurs over several days following the procedure with tenderness and limited arm range of motion lasting for weeks after surgery. Pain control typically commences in the perioperative period while the patient is in the hospital and may continue after discharge; outpatients may be given a prescription and advice for their analgesic regimen. It is not unusual for CIED patients to be discharged a few hours after implantation. While opioids are known as an effective analgesic to manage acute postoperative pain, growing scrutiny on opioid use as well as their side effects and potential risks have limited their use. Opioids may be considered for appropriate patients for a short course of treatment of acute postoperative pain, but other analgesics may likewise be considered.",book:{id:"10863",title:"Cardiac Rhythm Management - Pacing, Ablation, Devices",coverURL:"https://cdn.intechopen.com/books/images_new/10863.jpg"},signatures:"Peter Magnusson, Jo Ann LeQuang and Joseph V. Pergolizzi"},{id:"78786",title:"High-Power, Short-Duration Ablation in the Treatment of Atrial Fibrillation Patients",slug:"high-power-short-duration-ablation-in-the-treatment-of-atrial-fibrillation-patients",totalDownloads:105,totalDimensionsCites:0,doi:"10.5772/intechopen.100218",abstract:"Catheter ablation is the cornerstone of the rhythm control treatment of atrial fibrillation (AF). During this procedure, creating a contiguous and durable lesion set is essential to achieve good long-term results. Radiofrequency lesions are created in two phases: resistive and conductive heating. The ablation catheters and the generators have undergone impressive technical developments to enable homogenous and good-quality lesion creation. Despite recent years’ achievements, the durable isolation of the pulmonary veins remains a challenge. These days, intensive research aims to evaluate the role of high-power radiofrequency applications in the treatment of patients with cardiac arrhythmias. The use of high-power, short-duration applications might result in a uniform, transmural lesion set. It is associated with shorter procedure time, shorter left atrial, and fluoroscopy time than low-power ablation. This technique was also associated with a better clinical outcome, possibly due to the better durability of lesions. Multiple clinical studies have proven the safety and efficacy of high-power, short-duration PVI.",book:{id:"10863",title:"Cardiac Rhythm Management - Pacing, Ablation, Devices",coverURL:"https://cdn.intechopen.com/books/images_new/10863.jpg"},signatures:"Nándor Szegedi and László Gellér"},{id:"78224",title:"Epicardial Radiofrequency Ablation: Who, When, and How?",slug:"epicardial-radiofrequency-ablation-who-when-and-how",totalDownloads:80,totalDimensionsCites:0,doi:"10.5772/intechopen.99824",abstract:"In the past decades, it has been known that reentry circuits for ventricular tachycardia or focal triggers of premature ventricular complexes are not limited to the subendocardial myocardium. Rather, intramural or subepicardial substrates may also give rise to ventricular tachycardia, particularly in those with non-ischemic cardiomyopathy. Besides, some of the idiopathic ventricular tachycardia might be originated from epicardial foci. Percutaneous epicardial mapping and ablation have been successfully introduced to treat this sub-epicardiac ventricular tachycardia. Herein, this chapter reviews the indications for epicardial ablation and the identification of epicardial ventricular tachycardia by disease entity, electrocardiography and imaging modalities. This chapter also described the optimal technique for epicardial access and the potential complication.",book:{id:"10863",title:"Cardiac Rhythm Management - Pacing, Ablation, Devices",coverURL:"https://cdn.intechopen.com/books/images_new/10863.jpg"},signatures:"Chin-Yu Lin"}],onlineFirstChaptersTotal:6},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:null,scope:"