Ranking of lead pollution severity by region [1].
\r\n\t
",isbn:"978-1-80356-363-3",printIsbn:"978-1-80356-362-6",pdfIsbn:"978-1-80356-364-0",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"969d1c6315b04584c2f011e03dad69c2",bookSignature:"Dr. Mansoor Zoveidavianpoor",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11929.jpg",keywords:"Drilling Performance, Drilling Tools, Well Design, Drilling Procedure, Rotary Drilling, Directional Drilling, Measuring-While-Drilling, Smart Well Technology, Environment Protection, Geothermal Drilling, Sustainable Drilling Fluids, Carbon Sequestration",numberOfDownloads:7,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 18th 2022",dateEndSecondStepPublish:"March 18th 2022",dateEndThirdStepPublish:"May 17th 2022",dateEndFourthStepPublish:"August 5th 2022",dateEndFifthStepPublish:"October 4th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"4 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Dr. Zoveidavianpoor has over 18 years of multidisciplinary oil and gas experience, built upon his technical, operational, and management roles in the industry and academia. He is a member of the Society of Petroleum Engineers (SPE), the Energy Institute, UK and is registered as a chartered petroleum engineer. He has published more than 50 publications on International peer-reviewed Journals and conferences, has contributed to 5 textbooks, and served in many scientific committees.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"92105",title:"Dr.",name:"Mansoor",middleName:null,surname:"Zoveidavianpoor",slug:"mansoor-zoveidavianpoor",fullName:"Mansoor Zoveidavianpoor",profilePictureURL:"https://mts.intechopen.com/storage/users/92105/images/system/92105.jpg",biography:"Dr. Mansoor Zoveidavianpoor has over 24 years of experience, built upon his technical, operational, and management roles in the industry and academia. Mansoor holds a BSc degree in Geology, MSc, and Ph.D. degrees both in Petroleum Engineering. He was involved in different disciplines such as project management, geology, flow assurance, piping construction, artificial intelligence, environmental engineering, drilling and production engineering, He has lectured several courses at the University Technology Malaysia (UTM), Petroleum University of Technology (PUT), and Islamic Azad University (IAU). He is a member of the Society of Petroleum Engineers (SPE) and registered as a Chartered Petroleum Engineer at Energy Institute, and EIA subject specialist at DOE Malaysia. He has published more than 50 publications on International peer-reviewed Journals and conferences, has contributed to 5 textbooks, and served in many scientific committees. Currently, he is working as an Associate Professor at UTM and involved in several consultancies in petroleum engineering and energy transition. 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Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"6561",title:"Current Topics in the Utilization of Clay in Industrial and Medical Applications",subtitle:null,isOpenForSubmission:!1,hash:"e80257a8be3236c4d1ae37c21b7d2671",slug:"current-topics-in-the-utilization-of-clay-in-industrial-and-medical-applications",bookSignature:"Mansoor Zoveidavianpoor",coverURL:"https://cdn.intechopen.com/books/images_new/6561.jpg",editedByType:"Edited by",editors:[{id:"92105",title:"Dr.",name:"Mansoor",surname:"Zoveidavianpoor",slug:"mansoor-zoveidavianpoor",fullName:"Mansoor Zoveidavianpoor"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5811",title:"Recent Insights in Petroleum Science and Engineering",subtitle:null,isOpenForSubmission:!1,hash:"33b7777178f4a179ba475e3e15405427",slug:"recent-insights-in-petroleum-science-and-engineering",bookSignature:"Mansoor Zoveidavianpoor",coverURL:"https://cdn.intechopen.com/books/images_new/5811.jpg",editedByType:"Edited by",editors:[{id:"92105",title:"Dr.",name:"Mansoor",surname:"Zoveidavianpoor",slug:"mansoor-zoveidavianpoor",fullName:"Mansoor Zoveidavianpoor"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6829",title:"Petroleum Chemicals",subtitle:"Recent Insight",isOpenForSubmission:!1,hash:"058919afbb548d3448e70238b4637e84",slug:"petroleum-chemicals-recent-insight",bookSignature:"Mansoor Zoveidavianpoor",coverURL:"https://cdn.intechopen.com/books/images_new/6829.jpg",editedByType:"Edited by",editors:[{id:"92105",title:"Dr.",name:"Mansoor",surname:"Zoveidavianpoor",slug:"mansoor-zoveidavianpoor",fullName:"Mansoor Zoveidavianpoor"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10198",title:"Response Surface Methodology in Engineering Science",subtitle:null,isOpenForSubmission:!1,hash:"1942bec30d40572f519327ca7a6d7aae",slug:"response-surface-methodology-in-engineering-science",bookSignature:"Palanikumar Kayaroganam",coverURL:"https://cdn.intechopen.com/books/images_new/10198.jpg",editedByType:"Edited by",editors:[{id:"321730",title:"Prof.",name:"Palanikumar",surname:"Kayaroganam",slug:"palanikumar-kayaroganam",fullName:"Palanikumar Kayaroganam"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"58744",title:"High Voltage Energy Harvesters",doi:"10.5772/intechopen.72959",slug:"high-voltage-energy-harvesters",body:'Evolution of portable electronic devices over the past decades has led to surge in demand of batteries. The issues arise from using the batteries include maintenance cost, limited durability and associated environmental pollutions. Further, the size of battery becomes the bottleneck for miniaturization of electronic device. Table 1 shows the severity of lead battery pollution in some developing regions due to unregulated and immature recycling process [1]. Renewable energy sources have become the viable solution to overcome the limitations of batteries. Although such type of energy sources from wind and hydropower have long existed, they are used mainly to power electrical appliances in streets and buildings with large turbines rated at hundreds of kW [2]. Solar energy is another attractive option due to its high availability. However, the cost of solar panel is high and the manufacturing process is associated with air pollution. RF energy harvester has become a hot research topic in recent decades with emergence of RFID technology. Nevertheless, it is only useful for low power applications [2] and is thus not relevant to the interest of this chapter. Other available ambient energy sources include thermal energy, mechanical vibration and human activities. Implementation of small scale wind energy harvester is possible by using miniature brushless fan as a AC generator. Wind energy harvester is chosen to be focus of the works in the chapter as it fits the goal of sustainable development to create intelligent, autonomous and eco-friendly systems. Practically, windy condition can be created when moving on a transport or resting under a blowing fan. A well-designed energy harvester circuit can enhance the power generation efficiency.
Ranking of lead pollution severity by region [1].
Practically, it is desirable to boost the output voltage of energy harvester by connecting it to a voltage converter. The most intuitive way of boosting the output voltage of energy harvester is using step-up transformer. However, additional rectifier circuit is needed to convert the secondary voltage of transformer into DC voltage. Further, the size and cost of the transformer is a concern for realizing miniature energy harvester. Switch capacitor circuits [3, 4] and boost converters [5, 6, 7] could be used to serve the same purpose. However, they require additional clock signals at the input and is thus not feasible for use in energy harvester. Meanwhile, diode capacitor based voltage multipliers [8, 9, 10, 11, 12, 13, 14] are more preferred to be used in energy harvester circuit due to its simplicity in circuit architecture and low cost. The works presented in this chapter focus on using miniature wind energy harvester to generate high voltage (>10 V) for powering portable devices at milliwatt level.
Three different architectures of energy harvesters are detailed in this chapter. This first wind energy harvester adopts Cockcroft-Walton voltage quadruppler and a 2.4 W brushless fan to achieve more than 17 V DC at output. The second energy harvester is a AC to AC converter that uses a self-powered inverting op-amp to achieve the purpose. Lastly, a variable DC voltage generator is presented. It is formed by connecting a voltage doubler to the output of self-powered op-amp. They are detailed in Section 3. In Section 2, various architectures of existing voltage multipliers are exploited and reviewed.
In this section, the fundamentals of the voltage multipliers are reviewed.
The most fundamental component of a voltage doubler is basically a voltage clamp which was invented by Paul Ulrich Villard [8]. As shown in Figure 1(a), it consists of only a shunt diode and a series capacitor. During negative cycle of input voltage, diode D1 conducts and voltage across capacitor, Vc is charged to a value that is equivalent to peak amplitude of AC input voltage, Vp. In the next positive cycle, voltage seen at output terminal hit peak value of 2Vp as the capacitor now behaves as battery with DC potential of Vp. Overall, the resulted output voltage waveform is a similar copy of input AC voltage waveform but with DC level shifted from 0 to Vp. Nevertheless, voltage clamp cannot be used directly to power DC load due to unregulated output. Note that the analysis described above ignore the forward biasing voltage of diode, VD1 for ease of explanation. In practice, the maximum output voltage of diode voltage clamp is 2Vp−VD1. Figure 1(b) shows the comparison of input and output waveform.
(a) Villard voltage doubler circuit and (b) its corresponding input/output waveform [
Greinacher overcomes the deficiency of Villard voltage doubler by connecting an envelope detector in cascade with it at the output [9]. As shown in Figure 2(a), the envelope detector consists of a series diode, D2 that steer current generated from voltage clamp into storage capacitor. This operation occurs at positive cycles of input voltage whereby diode D2 is forward biased and diode D1 is reverse biased or open-circuited. As shown in Figure 2(b), the capacitor, C2 is charged up to 2(Vp−Vd) with voltage drops across diodes taking into consideration. During negative cycles, diode D2 acts as a potential barrier to ensure that only capacitor C1 is charged at that instance. With charging and discharging actions of storage capacitor, C2 across positive and negative operating cycles, the ripple content of voltage signal at the output is greatly reduced or smoothed. Intuitively, the efficiency of the voltage doubler could be improved by choosing diodes that have low forward bias voltage.
(a) Greinacher voltage doubler circuit and (b) it’s corresponding input/output waveform.
In 1932, John Douglas Cockcroft and Ernest Thomas Sinton Walton developed a voltage multiplier for powering their particle accelerator [10]. The circuit architecture proposed is basically cascading stages of Greinacher voltage doubler and thus it is also known as Greinacher voltage multiplier. With the cascading connections described, the output voltage could be further boosted by arbitrary times higher but at the cost of reduction in current drivability. Also, the output impedance increases proportionally with the number of multiplying stages as more stage capacitances are connected in series. Figure 3 illustrates the circuit architecture of Cockcroft-Walton voltage multiplier. Ideally, the n-cascading stage voltage doublers produces 2n times increased in output voltage.
N-stage Cockcroft-Walton voltage multiplier circuit [
In practice, the output voltage of Cockcroft-Walton voltage multiplier drops significantly from ideal prediction especially when the number of multiplying stages increases and significant loading current occurs at output. The regulation voltage,
Where,
Hence, the DC output voltage could be written as:
Meanwhile, the ripple voltage at the output of voltage multiplier is given as:
Based on (1) and (2), the loading impact on output voltage could be minimized by increasing the values of stage capacitances and frequency of input AC voltage. The performance of Cockcroft-Walton voltage multiplier will further deteriorates if the stray capacitances at coupling nodes are significant fractions of stage capacitances. Therefore, it is not suitable for applying on monolithic integrated circuits.
So far, the voltage multiplier circuits discussed in previous sections are classified as half-wave type since voltage at output appear as single polarity (Positive or minus) with respect to ground of input source. Instead, voltage doubler can be implemented using bridge circuit (Delon circuit) whereby two peak detectors with opposite polarities are stacked in series and fed by a common AC source (Figure 4). Thus, the voltage tapped across the outputs of peak detectors is twice the amplitude of AC source ideally. The orientation of diode determines the polarity of peak detector output since it only conducts either half of the operating cycle. As compared to Greinacher voltage doubler, there is no voltage clamp needed in bridge type voltage doubler for achieving the same purpose.
Delon bridge circuit.
Similarly, the half-wave Greinacher Voltage Doubler/Multiplier described in previous section could be extended to full-wave bridge configuration by stacking the negative version of it in series. Figure 5 illustrates the circuit schematic of full-wave Greinacher Voltage Doubler. The upper half version of the circuit is a positive voltage doubler whereby the lower half version is a negative voltage doubler. The resulted output voltage is double of those in half-wave version. Also, the voltage rating of stage capacitors (C3, C4) only need to be halved of those used in half-wave version for generating the same output voltage. As the ripple frequency of full-wave doubler is twice the supply frequency, it has lower ripple content than the half-wave voltage doubler. However, there is no common ground between the input and output.
Full-wave Greinacher voltage doubler circuit.
Dickson charge pump [11] was invented to overcome the deficiency of Cockcroft-Walton voltage multiplier in dealing with stray capacitances. Figure 6 shows the schematic of Dickson charge pump circuit where the output stage is a peak detector to hold the multiplied voltage at final stage. Under this configuration, clock signals with orthogonal phases are fed separately into capacitive coupling nodes at odd and even stages of charge pump. As compared to Cockcroft-Walton voltage multiplier, the stage capacitances in Dickson charge pump are parallel connected instead of series connected. The main advantages of this configuration are that the stray capacitances have little impact on the performance of voltage multiplier even with relatively high value. Also, the current drive capability is not affected by the number of multiplying stages. However, it is not suitable for high voltage application since the output node alone need to withstand the multiplied voltage entirely. As a result, the voltage rating of output capacitor becomes the bottleneck of maximum output voltage achievable. In addition to that, the circuit is not feasible for energy harvesting applications since it requires extra feeding of two anti-phase clock signals to operate. The operation principle of Dickson charge pump circuit can be summarized as follows:
During the zero cycle of the clock pulse,
As the clock signal,
Similar operations described are repeated for next subsequent stages of charge pump voltage multiplier. The final output voltage stored in C4 is captured by a peak detector consisting of diode, D5 and load capacitor, Cload.
Dickson charge pump circuit.
The output voltage of Dickson charge pump for N multiplying stages could be expressed as follow:
In order to improve the efficiency of Dickson charge pump, Schottky barrier diodes should be adopted due to its lower forward biasing voltage. However, such component is not readily available in CMOS technology. In such case, diode connected MOSFET [15, 16, 17] is more preferred due to its lower cost, wider availability and receives better support from Process Design Kits (PDKs). Figure 7 shows different version of Dickson charge pump circuit where conventional diodes are replaced by diode connected MOSFET. Nevertheless, the efficiency of such circuit is no better than those versions with Schottky barrier diodes due to its high threshold voltages and leakages. Although the threshold voltage of MOS transistor could be canceled using external biasing described in [17], the MOS transistor could not swing to “ON” state or “OFF” state fully. This resulted in high conduction resistance, leakage current, and thus lower efficiency. Active diode reviewed in next section presents a better alternative to conventional diode.
Dickson charge pump circuit based on diode connected MOSFETs.
For applications where the clock signals are absent, the Dickson charge pump circuit described in previous section could be modified such that the anti-phase clock signals are replaced by input AC source and its corresponding ground connection. This resulted in much simplified circuit as shown in Figure 8. The circuit configuration described is also known as Karthaus-Fischer cascade voltage multiplier [12, 13]. It is interesting to note that the unit voltage doubler cell is resembled back to a Greinacher Voltage Doubler. As compared to Cockcroft-Walton voltage multiplier, the inputs of all multiplying stages are parallel connected whereas their outputs are fed into voltage clamp of next multiplying stage. In addition to that, all output peak detectors of multiplying stages share the same ground as input.
Karthaus-Fischer cascade voltage multiplier circuit.
During the negative half cycle of the input sinusoidal signal, the pumping capacitors are pre-charged in parallel, and next positive half cycle charged pumping capacitors deliver current to the storage capacitors and output capacitor (CL) connected to the ground node. Input current from the received RF carrier enters to the diodes only half period of the signal in the half wave voltage multiplier.
Nevertheless, the modified Dickson charge pump is still associated with stringent requirement of capacitor ratings. Thus, another version of the charge pump is proposed in [14] whereby the output capacitances of multiplying stages are connected in series with each other instead (Figure 9). As a result, the minimum voltage rating required for each output capacitor is only twice of AC voltage amplitude at input. Such modifications also correspond to higher output impedances and thus implementation in full-wave configuration is recommended to reduce the impact of current loading.
Modified Karthaus-Fischer cascade voltage multiplier circuit.
Active diode based charge pump [18, 19, 20, 21] has been introduced lately as a good candidate for replacement of conventional diode in voltage multipliers. As shown in Figure 10, it is actually a comparator controlled active switch which turns on or off depending on the potential difference between anode and cathode terminal. When the voltage at anode terminal is greater than cathode terminal, the comparator output becomes low. As a result, the PMOS transistor connected to the comparator output is turned on and the entire circuit acts like a forward biased diode. The opposite happens when the voltage potential of cathode is greater than anode. It behaves like an ideal diode since only very small voltage difference at the comparator input is needed to trigger the active diode for operation in the desired state. Further, the conduction resistance of the ohmic CMOS switch is small while the reverse current is negligible due to high output impedance of PMOS switch. Thus, it has great advantages of driving low voltage input due to high sensitivity. Several types of voltage multipliers have been reported using active diodes. These include Delon, Dickson and off-chip Cockcroft–Walton types of voltage multipliers. Nevertheless, additional power supply is required for the comparator circuits and the power efficiency degrades with increases in input voltage due to more dominance of conduction loss in transistor switch.
Active diode circuit.
In this section, three small scale wind energy harvester circuits based on voltage multipliers are implemented for different types of applications. Cockcroft-Walton voltage multiplier scheme is adopted for all cases since it is more suitable for generating high voltage with less stringent demand on voltage ratings of capacitors. Also, it is more compact than the conventional transformer used for power generation. The voltage multipliers are designed using discrete components instead of integrated circuits to avoid the complex issues of stay capacitances. They are described in three separate sub-sections below.
A small-scale wind energy harvester circuit using voltage quadruppler is presented. As shown in Figure 11, it consists of two stages of Cockcroft-Walton voltage doubler that work as AC to DC booster. Schottky diodes, 1N5817 are used in the circuit given its low forward biasing voltage (≈0.3 V for current, Id < 0.1 A). This is essential to keep the efficiency of voltage quadruppler as high as possible. A miniature brushless fan is used in the reverse way as AC generator by removing its commutator circuit. The current rating of the fan is chosen to be high (0.2 A) for better powering of voltage quadruppler. It generates around 3.5 V AC rms voltage at 80 Hz. Meanwhile, the values of stage capacitances (220 μF) are optimized based on frequency of brushless fan (around 50 Hz) when rotating at fan speed. Choosing lower capacitances will enable the voltage multiplier circuit charge up faster to maximum DC voltage but at the cost of lower current drivability. Charging rate becomes slow when much higher capacitances are used and resulted in lower output DC voltage. The load devices used for this demonstration are LEDs. Therefore, voltage regulation issue is less concern since LEDs need very low current (in the order of μAs) to turn on or produce illuminations. The output of the voltage quadruppler is a peak detector that consists of diode, D5 and capacitor, C3. The capacitance value of C3 is chosen to be large since it is used as a battery to power the loads at the absence of AC input voltage. as well as filtering of ripples.
Quadruppler voltage generator circuit.
The operation principle of a single voltage doubler stage could be described as follows. During the negative half cycle of the AC voltage source, diode D1 will be forward biased and charge capacitor C1 to the maximum voltage amplitude of the AC source. In the next positive half cycle, diode D1 will become reverse biased and act as a potential barrier to block current from flowing through it. Meanwhile, diode D2 will be forward biased, charging capacitor C2 to twice the maximum voltage amplitude of the source. The same operation repeats at the second voltage doubler which boost output DC voltage to four times of input signal amplitude.
Due to large capacitance of C3, it took around 2 min to charge it fully. The DC output voltage generated under no load condition is around 17 V and 15.5 V with load connected. It matches the calculation in (2) which takes into consideration of voltage drop across diodes. As demonstrated in Figure 12, it can light up six blue LEDs for more than 7 min given the high capacity of storage capacitor, C3.
Demo photo of wind energy harvester using voltage quadruppler.
In the section, a self-powered AC voltage booster is presented for driving high AC voltage load instead of DC load discussed in previous section. Basically, the circuit comprises of a multi-stage Cockcroft-Walton voltage multiplier and an op-amp, LM324N. Here, the output of the voltage quadruppler is used as a DC supply for powering the op-amp. As compared to [18, 19, 20, 21], the op-amp is used as an inverting amplifier and not an active diode. The op-amp requires higher supply voltage to increase the operating range of output voltage when used as an amplifier. Meanwhile, the AC voltage generated from brushless fan is used as an input source for both op-amp and voltage quadruppler. The resistance ratio, R1/R2 can be used to adjust amplification factor of input AC signal injected. Nevertheless, the maximum dynamic range of the output voltage swing is governed by the DC supply from voltage multiplier. Therefore, it is desirable to have larger number of stages of voltage doublers to achieve higher amplification and output voltage swing. Note that the loading current of op-amp will deteriorate the maximum output voltage achievable as discussed in Section 2.3. The shunt capacitor, C3 with large value helps improving the current drivability by reducing the output impedance. It also helps providing stable DC power supply voltage to op-amp by smoothing the ripples. Figure 13 shows the schematic of proposed AC voltage booster using three-stage Cockcroft-Walton voltage doubler.
AC voltage booster circuit.
The functionality of the circuit is evaluated using MULTISIM software. As shown in Figure 14, the output AC voltage (Amplitude of 3 V) is twice of input AC source (Amplitude of 1.5 V) for resistance ratio, R1/R2 of op-amp set as 2. There is no distortion in the output as the DC power supply to the op-amp is well above the output voltage swing (6.96 V). Note that the input and output AC voltage are out of phase with each other since inverting op-amp is used in this case.
Simulated input and output voltage waveform of AC-AC converter.
Another version of the circuit (Figure 15) is implemented practically using only two stages of voltage doubler (voltage quadruppler) to power the op-amp. A function generator is used as the input of AC source instead for the purpose of analysis. The values of stage capacitances (100 μF) and storage capacitance (1000 μF) are chosen based on consideration on the load drivability of function generator. Meanwhile, the potential divider R3 and R4 act as the DC biasing circuit that determine the operating point of inverting op-amp. The biasing point is chosen to be at the midpoint of supply DC voltage to maximize the dynamic range of output voltage. Here, the impact of resistance ratio, R1/R2 on output AC voltage is studied experimentally. As shown in Figure 16, the output AC voltage increases proportionally with the resistance ratio, R1/R2 and saturates as the output voltage swing hits its supply limit. Note that the output AC voltage displayed is normalized with respect to those at unity resistance ratio (R1/R2 = 1). The maximum output voltage achievable using voltage quadruppler is around 1.5 times the input AC source. The result is within expectation since only one stage of voltage quadruppler is used to power the op-amp as compared to three stage voltage doublers described in previous simulation analysis.
Circuit photo of AC voltage booster.
Measured output AC voltage with normalization.
In actual applications, it is desirable to have variable DC power supply to meet the needs for different types of load devices. The conventional voltage quadruppler could be modified further using self-powered op-amp to provide varying supply DC voltage at output. Figure 17 shows the circuit schematic of variable DC voltage generator. It is similar to AC voltage multiplier circuit presented in Figure 13 with an exception that additional voltage multiplier stage is attached to the output of op-amp. The circuit works by using the resistance ratio of inverting op-amp to vary the output of connected voltage multiplier. The base voltage of the variable power supply could be further boosted up by tapping the ground connection of voltage multiplier at op-amp output to its own DC power supply node.
Variable DC voltage generator.
Circuit analysis is performed to evaluate the useful range of resistance ratio to be used for producing maximum variation of output voltage. The value of output voltage is normalized with respect to DC power supply from two stages of voltage quadruppler. As shown in Figure 18, the output DC voltage vary from DC power supply of op-amp to around 1.9 times of it. The useful range of resistance ratio to produce linear variation of output voltage is between 0 and 10 V for this case. Wider tuning range of output DC voltage is possible by cascading more numbers of voltage doublers at the output of inverting op-amp.
Simulated output DC voltage (normalized) versus resistor ratios of inverting op-amp.
As shown in Figure 19, the circuit is implemented on a breadboard using discrete capacitors, resistors and an op-amp. It is similar to the version shown in Figure 15 with an exception that a voltage doubler is connected to the output of op-amp to evaluate its functionality. Figure 20 shows the variation of output DC voltage across different resistor ratios, R1/R2 of inverting op-amp. The output voltage of the circuit spans from 8.8 to 14 V. This shows that the circuit indeed functions as a variable DC voltage generator.
Circuit photo of variable voltage generator.
Measured output DC voltage versus resistor ratios of inverting op-amp.
This chapter presents a miniature wind based energy harvester that is designed based on two stages of Cockcroft-Walton voltage doublers. The harvester circuit can generate 17 V DC voltage and light up six series connected blue LEDs for over 7 min when the source is disconnected. Such circuit can also be used directly for battery charging and power other high voltage device under windy environment. An AC voltage doubler based on self-powered inverting op-amp is also presented. It is attractive for use to replace transformer given its miniature size. Besides that, it could be extended for wireless charging application since boosted AC voltage can be transmitted wirelessly and provide more charging power than those harvest directly from RF signal. The self-powered inverting op-amp circuit could be transformed into variable DC voltage generator when a voltage multiplier is attached to its output. It can vary by 90% of op-amp supply voltage when a voltage doubler is connected at the output. By doing so, the circuit allows flexibility to powered electronic devices of different supply voltage requirements through harvesting energy from wind.
The authors would like to thank Singapore University of Technology & Design for the support to this publication.
Plants are sessile in nature and, as a result, they do not have the capability to escape from the site of unfavorable environment. As per circumstances, plants often face the challenges to grow under adverse environmental conditions such as water deficit or excess, high intense light, low or high temperature, salinity, heavy metals, UV rays, insect and pests attack, etc. These stresses wield adverse effects on plant growth and development by inducing many metabolic changes, such as the occurrence of an oxidative stress [1, 2, 3]. As a principal cause of global crop failure, abiotic stresses decrease average yields for major crops by more than 50% [4]. Abiotic stresses impact on growth, development and productivity, and significantly limit the global agricultural productivity mainly by impairing cellular physiology/biochemistry via elevating reactive oxygen species (ROS) generation. The production of ROS during abiotic stresses results from pathways such as photorespiration, the photosynthetic apparatus, and mitochondrial respiration. Additionally, pathogens and wounding or drought or osmotic stress have been also shown to activate the production of ROS by NADPH oxidases [5, 6, 7, 8]. The enhanced production of reactive oxygen species (ROS) during stress can pose a threat to cells, but it is also thought that ROI act as signals for the activation of stress-response and defense pathways [9, 10]. Thus, ROS can be viewed as cellular indicators of stress and as secondary messengers involved in the stress-response signal transduction pathway.
However, several anabolic and catabolic processes like photosynthesis and respiration occur as part of common aerobic metabolism. It has been proved that ROS are generated in different cellular compartments as mitochondria, chloroplasts, peroxisomes, cytoplasm or in the extracellular space, known as apoplast by action of different enzymes [11, 12]. In vegetative tissues, approximately 1–2% of total molecular oxygen consumption drives to the creation of ROS in normal conditions. This percentage increases when plants are subjected to stress conditions such as salinity, drought, cold stress, or high temperatures. ROS are the species generated through the reduction of molecular oxygen (O2) that includes some free radicals such as superoxide (O2•−), hydroxyl radical (OH•), alkoxyl (RO•), and peroxyl (ROO•), and nonradical products like hydrogen peroxide (H2O2) and singlet oxygen (1O2), etc. [11, 12, 13]. ROS generation is an unavoidable part and by-product in various metabolic processes, where 240 μM s−1 O2•− and 0.5 μM H2O2 can be observed in plants under optimal growth conditions. Further, abiotic stresses may significantly enhance the generation of varied ROS (and their reaction products) in plant cells, where stressed cells may exhibit accelerated ROS generation up to 720 μM s−1 O2•− and 5–15 μM H2O2 [14, 15] (Figure 1).
The concept of homeostasis condition (A) and imbalance (B) between reactive oxygen species (ROS) and antioxidants.
Plants have lot of antioxidant systems that protect them against these potential cytotoxic effects. Antioxidant enzymes are the most important components in the scavenging system of ROS. Major nonenzymatic antioxidants include ascorbic acid (AsA), glutathione (GSH), phenolic compounds, alkaloids, nonproteinaceous amino acids, and α-tocopherols. Alternatively, the battery of enzymatic antioxidants includes ascorbate peroxidase (APX), superoxide dismutase (SOD), glutathione reductase (GR), catalase (CAT), monodehydroascorbate reductase (MDHAR), dehydroascorbate reductase (DHAR), peroxidase (POX), glutathione peroxidase (GPX), guaiacol peroxidase (GOPX), and glutathione-S-transferase (GST) [15]. Considering the major enzymatic antioxidants, SOD
Superoxide dismutases (SODs: EC 1.15.1.1) are ubiquitous metalloenzymes [16, 17] that constitute the first line of defense against reactive oxygen species (ROS) and one of the most effective components of the antioxidant defense system in plant cells against ROS toxicity. Until reported in plants [19], SOD was recognized as a group of metalloproteins having no known function. Based on the metal cofactor at active site, SODs are categorized into three main groups and are believed to present in all oxygen-metabolizing cells and are also in all subcellular compartments like mitochondria, chloroplasts, nuclei, cytoplasm, peroxisomes, and apoplasts, etc. [20, 21]. It constitutes one of the major enzymatic components to detoxify superoxide radicals by catalyzing its dismutation to H2O2 [22]. By removing O2•−, SODs decrease the risk of OH• formation via the metal catalyzed Haber-Weiss-type reaction because this reaction has a 10,000-fold faster rate than the spontaneous dismutation [11]. This enzyme is unique that its activity determines the concentrations of O2•− and H2O2, the two Haber-Weiss reaction substrates, and it is therefore likely to be central in the antioxidant defense mechanism [23, 24]. The SOD system of higher plants exhibited into multiple isoforms, which are developmentally regulated and are highly reactive against exogenous stimuli. The significance in the efficiency of all SODs has been confirmed in the direct or indirect metabolism of diverse ROS and its reaction products in numerous studies [11, 19, 25]. According to the active site metal, the multiple SOD isoforms are classified into three major groups (types): Fe-SOD (iron cofactor), MnSOD (manganese cofactor), and Cu/ZnSOD (copper and zinc as cofactors; copper is the redox active catalytic metal). While in bacteria, another type of SOD called nickel SODs (Ni-SODs) has also been reported by many researchers with nickel as metal cofactor [19, 26, 27, 28]. These multiple SOD isoforms are designated to specific cell compartments namely Fe-SODs are located in plastids, Mn-SODs in mitochondrial matrix and peroxisomes, and they also have been found in cell wall, while Cu/Zn-SODs occur in cytosol, peroxisomes, plastids, and possibly extracellular space [19, 29, 30, 31]. All SODs are encoded by nuclear genes and targeted to their respective subcellular localization by an amino terminal guiding sequence (Table 1).
SOD isozymes | Structure | Subcellular localization | Sensitivity |
---|---|---|---|
Cu/Zn-SOD | Homodimeric and homotetrameric | Cytosol, chloroplast, peroxisome, mitochondria | H2O2 and KCN |
Mn-SOD | Homodimeric and homotetrameric | Mitochondria, peroxisome | CHCl3:CH3CH2OH but not to H2O2 and KCN |
Fe-SOD | Homodimeric and tetrameric | Cytosol, chloroplast, peroxisome, Mitochondria | H2O2 but not to KCN |
Ni-SOD | Only reported in prokaryotes |
Types of plant SOD, subcellular location, and sensitivity.
Different types of environmental stresses such as heat, cold, drought, salinity, and chemical contaminants commonly result in enhanced production of reactive oxygen species (ROS), and demand an effective scavenging system to prevent oxidative damage to living cells under such conditions. Thus, the understanding of the plant responses to these abiotic stresses has become a prerequisite in order to develop crop plants tolerating abiotic stresses. Nevertheless, as an important component of plant defense machinery within a cell, SODs are major enzymatic components of the cellular defense system against abiotic stress-accrued enhanced ROS. SODs are ubiquitous to aerobic organism and catalyze the dismutation of superoxide to molecular oxygen and hydrogen peroxide (H2O2). Under normal conditions, the resulting H2O2 is effectively scavenged by catalase and peroxidase enzymes. Hereunder, recent reports available on the modulation of SODs in abiotic-stressed plant species are discussed.
It has been observed under numerous studies that the higher the SOD activity or higher number of isoforms, greater the potential to remove ROS. The upregulation of SODs is implicated in combating over-produced ROS due to biotic or abiotic stresses and has a crucial role in the survival of the plant under stressful environment. Significant increase in total leaf SOD activities as well as some extra SOD isoforms (in some studies) has been reported in many plant species under various types of abiotic stresses, namely drought, salt, and heavy metals (Cu, Cd, etc.), in a number of crops like
Berwal et al. [44] studied the SOD isozymes pattern of 13 coconut genotypes comprising six tall, five dwarfs along with two reciprocal hybrids of WCT (tall) with COD (dwarf). Among the genotypes studied, a significant variation was observed in SOD enzyme activity as well as in SOD isoforms pattern. A total of 8–14 SOD isoforms were detected in different coconut cultivars (Figures 2 and 3). The variation was observed only in Mn-SOD isoforms, while Fe-SOD (two) and Cu/Zn-SOD (five) isoforms were similar in all the analyzed cultivars; these isoforms have already been identified in coconut by Kumar et al. [25]. Mn-SOD isoforms varied from one to five in numbers. Among the tall cultivars, WCT, FMST, and WCT X COD showed highest number (five) of Mn-SOD isoforms as well as highest enzymatic activity followed by LCT while TPT, PHOT, and ADOT showed only single isoform for Mn-SOD. All dwarfs studies showed that they had similar SOD isozyme profile for all SODs, that is, one Mn-SOD, five Cu/Zn-SOD, and two Fe-SOD isoforms. They also observed that Mn-SOD does not follow the Mendelian pattern of inheritance, that is, reciprocal crosses showed Mn-SOD isoform pattern similar to their mother palm.
Manganese superoxide dismutase (Mn-SOD) isoform variability in coconut genotypes (circled): (A) tall accessions and (B) dwarf accessions [
Manganese superoxide dismutase (Mn-SOD) isoform pattern of WCT, COD, and their reciprocal crosses [
Rajgopal et al. [45] also studied the tolerance level of different coconut cultivars including the abovementioned cultivars on the basis of some physiological parameters like stomatal conductance, leaf water potential, and epicuticular wax content and scored them with 1–20 rank and WCT X WCT and FMST secured first and second ranks, respectively. Since, Berwal et al. [44] reported maximum SOD isoforms in WCT and FMST cultivars and the same are already reported as highest stress tolerant cultivars. Similarly, Kumar et al. [38] evaluated basal enzymatic antioxidative metabolism in the developing leaves of commercially grown citrus such as grapefruit, Hamlin (sweet orange), and kumquat. Young leaves of kumquat exhibited lower rates of lipid peroxidation and H2O2 generation as compared to grapefruit and sweet Hamlin. The total superoxide dismutase (SOD) activity, which catalyzes the transmutation of superoxide ion to H2O2, was twofold higher in kumquat than grapefruit and sweet orange. Kumquat also showed more superoxide dismutase isoforms activities (Figure 1. Isoforms of superoxide dismutase (SOD; Panel A) and band intensities (Panel B) in developing leaves of different genotypes of citrus and kumquat at pp. 93, Kumar et al. [38]).
Despite the higher superoxide dismutase activity in kumquat, it had substantially lower H2O2 than grapefruit and Hamlin; and this is well-known that kumquat has greater resistance towards oxidative stresses. Gueta-Dahan et al. [46] also reported in citrus, callus, and cold-acclimated mandarin fruits and suggested higher SOD activity conferred greater resistance to salt and chilling stress (Figure 8. SOD activities in salt-sensitive (L) and salt-tolerant (R) citrus cells at pp. 465). Vysniauskiene et al. [47] reported higher SOD activity in frost-resistant potato hybrids than that of in frost-sensitive
Activities of cytosolic and chloroplastic Cu/Zn-SOD isozymes and cytosolic APX (cAPX), as well as their corresponding mRNA transcripts, were increased by drought treatment of pea plants [48]. Similarly, osmotic stress increased the Mn-SOD transcript abundance in maize [49]. The higher level of gene expression corresponding to this isozyme as well as for Cu/Zn-SOD, were also increased by chilling stress in tobacco plants [50]. It has been reported in many studies that higher level of Mn-SOD is linked with abiotic stress tolerance and Melchiorre et al. [51] reported photo-oxidative stress tolerance, lower oxidative damage, and higher H2O2 in
Superoxide dismutase is known as the first line of defense against oxidative stresses in plants and play most vital role is scavenging the reactive oxygen species produced during metabolic processes as well as under abiotic stress conditions. From the above discussion, it is clear that the plant has more native or induced SOD activity that showed more tolerance toward abiotic stresses. Many studies have proved that higher the native SOD activity along with more number of SOD isoforms makes the plants more capable to scavenge the ROS generated during stressed condition more effectively. As reported by Berwal et al. [44] in coconut and Kumar et al. [38] in citrus species that the cultivar having more number of native SOD isoforms showed more tolerance against drought stress. Therefore, the native SOD isozyme profile can be used as a stable biochemical marker for screening of crop germplasm for abiotic stress tolerance.
This is a brief overview of the main steps involved in publishing with IntechOpen Compacts, Monographs and Edited Books. Once you submit your proposal you will be appointed a Author Service Manager who will be your single point of contact and lead you through all the described steps below.
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From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. 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Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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Singh",profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8018",title:"Extracellular Matrix",subtitle:"Developments and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/8018.jpg",slug:"extracellular-matrix-developments-and-therapeutics",publishedDate:"October 27th 2021",editedByType:"Edited by",bookSignature:"Rama Sashank Madhurapantula, Joseph Orgel P.R.O. and Zvi Loewy",hash:"c85e82851e80b40282ff9be99ddf2046",volumeInSeries:23,fullTitle:"Extracellular Matrix - Developments and Therapeutics",editors:[{id:"212416",title:"Dr.",name:"Rama Sashank",middleName:null,surname:"Madhurapantula",slug:"rama-sashank-madhurapantula",fullName:"Rama Sashank Madhurapantula",profilePictureURL:"https://mts.intechopen.com/storage/users/212416/images/system/212416.jpg",institutionString:"Illinois Institute of Technology",institution:{name:"Illinois Institute of Technology",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9759",title:"Vitamin E in Health and Disease",subtitle:"Interactions, Diseases and Health Aspects",coverURL:"https://cdn.intechopen.com/books/images_new/9759.jpg",slug:"vitamin-e-in-health-and-disease-interactions-diseases-and-health-aspects",publishedDate:"October 6th 2021",editedByType:"Edited by",bookSignature:"Pınar Erkekoglu and Júlia Scherer Santos",hash:"6c3ddcc13626110de289b57f2516ac8f",volumeInSeries:22,fullTitle:"Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects",editors:[{id:"109978",title:"Prof.",name:"Pınar",middleName:null,surname:"Erkekoğlu",slug:"pinar-erkekoglu",fullName:"Pınar Erkekoğlu",profilePictureURL:"https://mts.intechopen.com/storage/users/109978/images/system/109978.jpg",institutionString:"Hacettepe University",institution:{name:"Hacettepe University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Proteomics",value:18,count:4},{group:"subseries",caption:"Metabolism",value:17,count:6},{group:"subseries",caption:"Cell and Molecular Biology",value:14,count:9},{group:"subseries",caption:"Chemical Biology",value:15,count:13}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:8},{group:"publicationYear",caption:"2021",value:2021,count:7},{group:"publicationYear",caption:"2020",value:2020,count:12},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:2}],authors:{paginationCount:229,paginationItems:[{id:"318170",title:"Dr.",name:"Aneesa",middleName:null,surname:"Moolla",slug:"aneesa-moolla",fullName:"Aneesa Moolla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/318170/images/system/318170.png",biography:"Dr. Aneesa Moolla has extensive experience in the diverse fields of health care having previously worked in dental private practice, at the Red Cross Flying Doctors association, and in healthcare corporate settings. She is now a lecturer at the University of Witwatersrand, South Africa, and a principal researcher at the Health Economics and Epidemiology Research Office (HE2RO), South Africa. Dr. Moolla holds a Ph.D. in Psychology with her research being focused on mental health and resilience. In her professional work capacity, her research has further expanded into the fields of early childhood development, mental health, the HIV and TB care cascades, as well as COVID. She is also a UNESCO-trained International Bioethics Facilitator.",institutionString:"University of the Witwatersrand",institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419588",title:"Ph.D.",name:"Sergio",middleName:"Alexandre",surname:"Gehrke",slug:"sergio-gehrke",fullName:"Sergio Gehrke",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038WgMKQA0/Profile_Picture_2022-06-02T11:44:20.jpg",biography:"Dr. Sergio Alexandre Gehrke is a doctorate holder in two fields. The first is a Ph.D. in Cellular and Molecular Biology from the Pontificia Catholic University, Porto Alegre, Brazil, in 2010 and the other is an International Ph.D. in Bioengineering from the Universidad Miguel Hernandez, Elche/Alicante, Spain, obtained in 2020. In 2018, he completed a postdoctoral fellowship in Materials Engineering in the NUCLEMAT of the Pontificia Catholic University, Porto Alegre, Brazil. He is currently the Director of the Postgraduate Program in Implantology of the Bioface/UCAM/PgO (Montevideo, Uruguay), Director of the Cathedra of Biotechnology of the Catholic University of Murcia (Murcia, Spain), an Extraordinary Full Professor of the Catholic University of Murcia (Murcia, Spain) as well as the Director of the private center of research Biotecnos – Technology and Science (Montevideo, Uruguay). Applied biomaterials, cellular and molecular biology, and dental implants are among his research interests. He has published several original papers in renowned journals. In addition, he is also a Collaborating Professor in several Postgraduate programs at different universities all over the world.",institutionString:null,institution:{name:"Universidad Católica San Antonio de Murcia",country:{name:"Spain"}}},{id:"342152",title:"Dr.",name:"Santo",middleName:null,surname:"Grace Umesh",slug:"santo-grace-umesh",fullName:"Santo Grace Umesh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/342152/images/16311_n.jpg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"333647",title:"Dr.",name:"Shreya",middleName:null,surname:"Kishore",slug:"shreya-kishore",fullName:"Shreya Kishore",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333647/images/14701_n.jpg",biography:"Dr. Shreya Kishore completed her Bachelor in Dental Surgery in Chettinad Dental College and Research Institute, Chennai, and her Master of Dental Surgery (Orthodontics) in Saveetha Dental College, Chennai. She is also Invisalign certified. She’s working as a Senior Lecturer in the Department of Orthodontics, SRM Dental College since November 2019. She is actively involved in teaching orthodontics to the undergraduates and the postgraduates. Her clinical research topics include new orthodontic brackets, fixed appliances and TADs. She’s published 4 articles in well renowned indexed journals and has a published patency of her own. Her private practice is currently limited to orthodontics and works as a consultant in various clinics.",institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"323731",title:"Prof.",name:"Deepak M.",middleName:"Macchindra",surname:"Vikhe",slug:"deepak-m.-vikhe",fullName:"Deepak M. Vikhe",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/323731/images/13613_n.jpg",biography:"Dr Deepak M.Vikhe .\n\n\t\n\tDr Deepak M.Vikhe , completed his Masters & PhD in Prosthodontics from Rural Dental College, Loni securing third rank in the Pravara Institute of Medical Sciences Deemed University. He was awarded Dr.G.C.DAS Memorial Award for Research on Implants at 39th IPS conference Dubai (U A E).He has two patents under his name. He has received Dr.Saraswati medal award for best research for implant study in 2017.He has received Fully funded scholarship to Spain ,university of Santiago de Compostela. He has completed fellowship in Implantlogy from Noble Biocare. \nHe has attended various conferences and CDE programmes and has national publications to his credit. His field of interest is in Implant supported prosthesis. Presently he is working as a associate professor in the Dept of Prosthodontics, Rural Dental College, Loni and maintains a successful private practice specialising in Implantology at Rahata.\n\nEmail: drdeepak_mvikhe@yahoo.com..................",institutionString:null,institution:{name:"Pravara Institute of Medical Sciences",country:{name:"India"}}},{id:"204110",title:"Dr.",name:"Ahmed A.",middleName:null,surname:"Madfa",slug:"ahmed-a.-madfa",fullName:"Ahmed A. Madfa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204110/images/system/204110.jpg",biography:"Dr. Madfa is currently Associate Professor of Endodontics at Thamar University and a visiting lecturer at Sana'a University and University of Sciences and Technology. He has more than 6 years of experience in teaching. His research interests include root canal morphology, functionally graded concept, dental biomaterials, epidemiology and dental education, biomimetic restoration, finite element analysis and endodontic regeneration. Dr. Madfa has numerous international publications, full articles, two patents, a book and a book chapter. Furthermore, he won 14 international scientific awards. Furthermore, he is involved in many academic activities ranging from editorial board member, reviewer for many international journals and postgraduate students' supervisor. Besides, I deliver many courses and training workshops at various scientific events. Dr. Madfa also regularly attends international conferences and holds administrative positions (Deputy Dean of the Faculty for Students’ & Academic Affairs and Deputy Head of Research Unit).",institutionString:"Thamar University",institution:null},{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",biography:"Dr. Nermin Mohammed Ahmed Yussif is working at the Faculty of dentistry, University for October university for modern sciences and arts (MSA). Her areas of expertise include: periodontology, dental laserology, oral implantology, periodontal plastic surgeries, oral mesotherapy, nutrition, dental pharmacology. She is an editor and reviewer in numerous international journals.",institutionString:"MSA University",institution:null},{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",country:{name:"India"}}},{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null},{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178412/images/6954_n.jpg",biography:"Assoc. Prof. Dr. Gühan Dergin was born in 1973 in Izmit. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry and obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Dergin still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. He has many articles in international and national scientific journals and chapters in books.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178414/images/6953_n.jpg",biography:"Born in Istanbul in 1974, Dr. Emes graduated from Istanbul University Faculty of Dentistry in 1997 and completed his PhD degree in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery in 2005. He has papers published in international and national scientific journals, including research articles on implantology, oroantral fistulas, odontogenic cysts, and temporomandibular disorders. Dr. Emes is currently working as a full-time academic staff in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery.",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"192229",title:"Ph.D.",name:"Ana Luiza",middleName:null,surname:"De Carvalho Felippini",slug:"ana-luiza-de-carvalho-felippini",fullName:"Ana Luiza De Carvalho Felippini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192229/images/system/192229.jpg",biography:null,institutionString:"University of São Paulo",institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256851/images/9696_n.jpg",biography:"Dr. Ayşe Gülşen graduated in 1990 from Faculty of Dentistry, University of Ankara and did a postgraduate program at University of Gazi. \nShe worked as an observer and research assistant in Craniofacial Surgery Departments in New York, Providence Hospital in Michigan and Chang Gung Memorial Hospital in Taiwan. \nShe works as Craniofacial Orthodontist in Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi, Ankara Turkey since 2004.",institutionString:"Univeristy of Gazi",institution:null},{id:"255366",title:"Prof.",name:"Tosun",middleName:null,surname:"Tosun",slug:"tosun-tosun",fullName:"Tosun Tosun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255366/images/7347_n.jpg",biography:"Graduated at the Faculty of Dentistry, University of Istanbul, Turkey in 1989;\nVisitor Assistant at the University of Padua, Italy and Branemark Osseointegration Center of Treviso, Italy between 1993-94;\nPhD thesis on oral implantology in University of Istanbul and was awarded the academic title “Dr.med.dent.”, 1997;\nHe was awarded the academic title “Doç.Dr.” (Associated Professor) in 2003;\nProficiency in Botulinum Toxin Applications, Reading-UK in 2009;\nMastership, RWTH Certificate in Laser Therapy in Dentistry, AALZ-Aachen University, Germany 2009-11;\nMaster of Science (MSc) in Laser Dentistry, University of Genoa, Italy 2013-14.\n\nDr.Tosun worked as Research Assistant in the Department of Oral Implantology, Faculty of Dentistry, University of Istanbul between 1990-2002. \nHe worked part-time as Consultant surgeon in Harvard Medical International Hospitals and John Hopkins Medicine, Istanbul between years 2007-09.\u2028He was contract Professor in the Department of Surgical and Diagnostic Sciences (DI.S.C.), Medical School, University of Genova, Italy between years 2011-16. \nSince 2015 he is visiting Professor at Medical School, University of Plovdiv, Bulgaria. \nCurrently he is Associated Prof.Dr. at the Dental School, Oral Surgery Dept., Istanbul Aydin University and since 2003 he works in his own private clinic in Istanbul, Turkey.\u2028\nDr.Tosun is reviewer in journal ‘Laser in Medical Sciences’, reviewer in journal ‘Folia Medica\\', a Fellow of the International Team for Implantology, Clinical Lecturer of DGZI German Association of Oral Implantology, Expert Lecturer of Laser&Health Academy, Country Representative of World Federation for Laser Dentistry, member of European Federation of Periodontology, member of Academy of Laser Dentistry. Dr.Tosun presents papers in international and national congresses and has scientific publications in international and national journals. He speaks english, spanish, italian and french.",institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"256417",title:"Associate Prof.",name:"Sanaz",middleName:null,surname:"Sadry",slug:"sanaz-sadry",fullName:"Sanaz Sadry",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256417/images/8106_n.jpg",biography:null,institutionString:null,institution:null},{id:"272237",title:"Dr.",name:"Pinar",middleName:"Kiymet",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272237/images/8911_n.png",biography:"Assist.Prof.Dr.Pınar Kıymet Karataban, DDS PhD \n\nDr.Pınar Kıymet Karataban was born in Istanbul in 1975. After her graduation from Marmara University Faculty of Dentistry in 1998 she started her PhD in Paediatric Dentistry focused on children with special needs; mainly children with Cerebral Palsy. She finished her pHD thesis entitled \\'Investigation of occlusion via cast analysis and evaluation of dental caries prevalance, periodontal status and muscle dysfunctions in children with cerebral palsy” in 2008. She got her Assist. Proffessor degree in Istanbul Aydın University Paediatric Dentistry Department in 2015-2018. ın 2019 she started her new career in Bahcesehir University, Istanbul as Head of Department of Pediatric Dentistry. In 2020 she was accepted to BAU International University, Batumi as Professor of Pediatric Dentistry. She’s a lecturer in the same university meanwhile working part-time in private practice in Ege Dental Studio (https://www.egedisklinigi.com/) a multidisciplinary dental clinic in Istanbul. Her main interests are paleodontology, ancient and contemporary dentistry, oral microbiology, cerebral palsy and special care dentistry. She has national and international publications, scientific reports and is a member of IAPO (International Association for Paleodontology), IADH (International Association of Disability and Oral Health) and EAPD (European Association of Pediatric Dentistry).",institutionString:null,institution:null},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202198/images/6955_n.jpg",biography:"Buket Aybar, DDS, PhD, was born in 1971. She graduated from Istanbul University, Faculty of Dentistry, in 1992 and completed her PhD degree on Oral and Maxillofacial Surgery in Istanbul University in 1997.\nDr. Aybar is currently a full-time professor in Istanbul University, Faculty of Dentistry Department of Oral and Maxillofacial Surgery. She has teaching responsibilities in graduate and postgraduate programs. Her clinical practice includes mainly dentoalveolar surgery.\nHer topics of interest are biomaterials science and cell culture studies. She has many articles in international and national scientific journals and chapters in books; she also has participated in several scientific projects supported by Istanbul University Research fund.",institutionString:null,institution:null},{id:"260116",title:"Dr.",name:"Mehmet",middleName:null,surname:"Yaltirik",slug:"mehmet-yaltirik",fullName:"Mehmet Yaltirik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/260116/images/7413_n.jpg",biography:"Birth Date 25.09.1965\r\nBirth Place Adana- Turkey\r\nSex Male\r\nMarrial Status Bachelor\r\nDriving License Acquired\r\nMother Tongue Turkish\r\n\r\nAddress:\r\nWork:University of Istanbul,Faculty of Dentistry, Department of Oral Surgery and Oral Medicine 34093 Capa,Istanbul- TURKIYE",institutionString:null,institution:null},{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/172009/images/7122_n.jpg",biography:"Dr. Deniz Uzuner was born in 1969 in Kocaeli-TURKEY. After graduating from TED Ankara College in 1986, she attended the Hacettepe University, Faculty of Dentistry in Ankara. \nIn 1993 she attended the Gazi University, Faculty of Dentistry, Department of Orthodontics for her PhD education. After finishing the PhD education, she worked as orthodontist in Ankara Dental Hospital under the Turkish Government, Ministry of Health and in a special Orthodontic Clinic till 2011. Between 2011 and 2016, Dr. Deniz Uzuner worked as a specialist in the Department of Orthodontics, Faculty of Dentistry, Gazi University in Ankara/Turkey. In 2016, she was appointed associate professor. Dr. Deniz Uzuner has authored 23 Journal Papers, 3 Book Chapters and has had 39 oral/poster presentations. She is a member of the Turkish Orthodontic Society. Her knowledge of English is at an advanced level.",institutionString:null,institution:null},{id:"332914",title:"Dr.",name:"Muhammad Saad",middleName:null,surname:"Shaikh",slug:"muhammad-saad-shaikh",fullName:"Muhammad Saad Shaikh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jinnah Sindh Medical University",country:{name:"Pakistan"}}},{id:"315775",title:"Dr.",name:"Feng",middleName:null,surname:"Luo",slug:"feng-luo",fullName:"Feng Luo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sichuan University",country:{name:"China"}}},{id:"423519",title:"Dr.",name:"Sizakele",middleName:null,surname:"Ngwenya",slug:"sizakele-ngwenya",fullName:"Sizakele Ngwenya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419270",title:"Dr.",name:"Ann",middleName:null,surname:"Chianchitlert",slug:"ann-chianchitlert",fullName:"Ann Chianchitlert",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419271",title:"Dr.",name:"Diane",middleName:null,surname:"Selvido",slug:"diane-selvido",fullName:"Diane Selvido",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419272",title:"Dr.",name:"Irin",middleName:null,surname:"Sirisoontorn",slug:"irin-sirisoontorn",fullName:"Irin Sirisoontorn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"355660",title:"Dr.",name:"Anitha",middleName:null,surname:"Mani",slug:"anitha-mani",fullName:"Anitha Mani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"355612",title:"Dr.",name:"Janani",middleName:null,surname:"Karthikeyan",slug:"janani-karthikeyan",fullName:"Janani Karthikeyan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"334400",title:"Dr.",name:"Suvetha",middleName:null,surname:"Siva",slug:"suvetha-siva",fullName:"Suvetha Siva",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}}]}},subseries:{item:{id:"86",type:"subseries",title:"Business and Management",keywords:"Demographic shifts, Innovation, Technology, Next-gen leaders, Worldwide environmental issues and clean technology, Uncertainty and political risks, Radical adjacency, Emergence of new business ecosystem type, Emergence of different leader and leader values types, Universal connector, Elastic enterprise, Business platform, Supply chain complexity",scope:"