Infectious diseases after spinal cord injury (SCI) are important. They can cause mortality and morbidity. The SCI patients usually stay in hospital or rehabilitation units for a long time, and this can cause several complications for them.
- spinal cord
Infectious complications are supposed to be an important cause of morbidity and mortality in patients with spinal cord injury (SCI). Infectious diseases may lead to death and several complications such as prolonged hospital stay and increased cost of management of patients. Several organs may be affected and problems in these organs can be even more important than the primary event. The types of infections in these patients are different and related to several factors. Inabilities to changing position or ineffective cough, using several necessary devices, prolonged hospitalization, and several other factors, in patients with SCI, predispose them to different types of infections. Inability to walk, sit, or change position may lead to pressure ulcers, skin and soft tissue infection, and osteomyelitis. Reduced tissue perfusion increases the spinal cord-injured patient’s susceptibility to pressure ulcers  during the acute and rehabilitation phases, most frequently over bony prominences such as the sacrum, tuber ischii, heel, malleolus, and trochanter . Physical and psychosocial elements such as nutrition, past history of pressure ulcers, and social supports can be important in developing ulcers . Ineffective cough and retained pulmonary secretion may lead to pneumonia. Most of the patients need intubation in the course of hospitalization that predisposes them to ventilator-associated pneumonia. Ventilator-associated pneumonia is the most frequent nosocomial infection in patients receiving mechanical ventilation and contributes to a longer intensive care unit stay and high morbidity and mortality [4, 5]. Use of high doses of corticosteroid for management of some patients with SCI can increase the risk of infection. In those patients who need surgical intervention, the operation time is usually prolonged. Sometimes, the use of an external device is mandatory for fixation of unstable vertebral column. The SCI patients may develop bloodstream infection during the hospital admission. During bloodstream infection occurrence in an SCI population, multidrug-resistant organisms are frequent . ICU-acquired bloodstream infection in the intensive care unit is still associated with a high mortality rate. The increase of antimicrobial drug resistance makes its treatment increasingly challenging. ICU bloodstream infection is associated with a 40% increase in the risk of 30-day mortality, particularly if the early antimicrobial therapy is not adequate . Paying attention to antibiotic therapy is important in SCI patients. Antibiotic resistance is of great concern for both infection control and the treatment of infectious diseases. Drug-resistant pathogens, such as methicillin-resistant
These can be the risk factors for developing infections in SCI patients. In this chapter, the cause of infections, predisposing factors, diagnosis, management, and prevention will be discussed.
2. Infectious diseases after spinal cord injury
2.1. Urinary tract infection
Urinary tract infections (UTI) still cause significant morbidity in patients with spinal cord injury, although mortality due to urinary tract complications has decreased dramatically . Patients with spinal cord injuries (SCIs) and complete or incomplete paraplegia are prone to frequent, recurrent, or chronic UTI. The reason for the increased risk of acquiring UTI is multifactorial, including reduced sensation of classical UTI symptoms, incomplete bladder emptying, frequent catheterizations, or chronic urinary tract catheters . The rate of UTI in an SCI patient is 2.5 episodes in patient per year. UTI is the second leading cause of mortality in SCI patients . Patients with SCI who have urinary catheters have an increased risk of UTI. Urinary tract infection can be important and can cause serious complications including sepsis and septic shock if it is not diagnosed and treated.
Using Foley catheter is usually accompanied with colonization of microorganisms and infection . Bacterial biofilm formation of Foley catheter can cause cystitis . About 80% of UTIs follow urinary catheter insertion. Nitrofurazone-coated and silver alloy-coated catheters can decrease asymptomatic bacteriuria during short-term (<30 days) use in comparison with latex or silicon catheters. The risk of infection is higher with long-term catheterization, and it is safe to remove it early after surgery. Latex and silicone catheters have the same infection rates, but Foley catheters cause more symptomatic bacteriuria and UTI than intermittent catheterizations. Changing the drainage bags and adding antiseptic solution to bags cannot prevent UTI in patients . There are several risk factors for UTI in SCI patients. Reflux of vesicoureteral, postvoiding residuals, outlet obstruction, urinary tract stones, and bladder overdistension . These patients are exposed to antibiotics because of frequent infections that may be an important risk factor for resistant microorganism infection . Today, UTI may be difficult to treat in SCI patients because of antibiotic-resistant organisms. The SCI patients are also colonized by resistant organisms because of recurrent and prolonged hospitalization . The main causative agent of UTI in SCI population is usually derived from the patient’s flora. The indwelling catheter has a great role in infection and the duration of catheterization is the most important risk factor. If the patient carries a catheter more than 30 days, the risk of infection with multiple organisms will increase. Although short-term catheterization can be risk factor for bacteriuria, it is usually asymptomatic and often by a single microorganism . It is better to use hydrophilic-coated catheter for intermittent catheterization in SCI patients during acute inpatient rehabilitation. These kinds of catheters can postpone the development of UTI. They also reduce the incidence of bacteriuria and infection. Reduction of complications and treatment costs and preventing the emergence of antibiotic-resistant organisms are other benefits of hydrophilic-coated catheters . Substitution of indwelling catheter with intermittent catheterization during the rehabilitation phase will reduce development of UTI . The unitary catheter should work in a closed system so that no organism can enter the system. It is also important to reduce the duration of catheterization. Sometimes intermittent catheterization, condom sheet catheter, and suprapubic catheters may substitute indwelling catheterization to reduce the risk of infection . Intermittent catheterization is safe and is advised to prevent UTI in SCI patients. Condom sheet catheter can be used in patients who are able to urinate and there is no pathology or injury in urethra. In some patients, where using condom sheet catheter or intermittent catheterization is not suitable or possible, the physician may decide to use suprapubic catheter. The physicians should be aware of these two points that SCI patients may not have the classic symptoms of UTI and urinary infection may cause urologic complications .
Diagnosis of UTI is usually based on the results of urine culture, although in some condition like low titer of organism in urine, slow-growing pathogens and unusual organisms, results of culture may be unreliable . The physician should be aware of how to diagnose UTI and distinguish it from colonization. These patients are at increased risk of acquiring multidrug-resistant bacteria because they are admitted due to UTI or other infectious diseases and take antibiotics. Several resistant organisms may cause UTI in SCI patients including multidrug-resistant
Differentiating infection from colonization and asymptomatic bacteriuria from symptomatic infection is an important point in treatment of UTI in SCI patient. A symptomatic patient needs to be treated, and after treatment, long duration of antibiotic suppressive therapy is not necessary . For treatment of UTI, usually, there are many antibiotic options. It is better to postpone the treatment until the result of culture. Sometimes it is necessary to treat the patient empirically. Some variables like probable organism and susceptibility, administration route (oral vs. intravenous), the patient tolerance, renal function, and the patients’ other medications should be considered for choosing appropriate antibiotic . Duration of treatment of chronic UTI in SCI patient may need to be extended. Some studies recommend and some do not. It seems more studies are needed for certain recommendations . The best antibiotics are those that have the most therapeutic effect on causative agent, without any or with less impact on the host normal flora. This antibiotic is best chosen according to result of urine culture and antibiogram. Duration of treatment is usually 5 days but may be extended to 7–14 days when reinfection or relapse occurs . Some studies recommend treating urinary infection between 10 and 14 days in SCI patients, especially when it is not possible to discontinue the urinary catheter. To determine the optimal duration of treatment, multicentral and randomized clinical trial may be necessary . Darouiche’s study demonstrates that the 5-day treatment with urinary catheter exchange can be as effective as a 10-day regimen with catheter retention . Antibiotics usually are chosen according to urine culture. Third generation of cephalosporines, carbapenems, and quinolones are often used to treat Gram-negative organisms. For treatment of
2.1.3. Prevention and prophylaxis
Prevention of UTI in SCI patients plays an important role in hospital and even in rehabilitation courses of these patients. Paying attention to urinary tract hygiene is necessary. Some patients may encounter relapse or reinfection. In these patients, evaluation of structural and functional disorders should be performed. Duration of previous treatment and probable complications like urine residue and urinary stone should be assessed. Antibiotics may be used as prophylaxis, but it is important to notice that it can be used when recurrent UTI occurs and when all structural and functional abnormalities are corrected. Prophylaxis is not recommended for patients carrying indwelling catheters, and for those who have intermittent catheterization, it is contraventional . Physicians can most effectively prevent UTI by avoiding use of long-term catheters, short duration of catheter use, and substituting intermittent catheterization with indwelling catheter. Daily washing of the catheter or perianal or periurethral areas has no preventive effect. It is recommended to use antibiotic immediately before any invasive procedure on urinary tract system . Probiotics may be useful as prophylactic agents. They may decrease the number of resistant organisms’ colonization and may be an attractive substitution for antibiotics for prophylaxis in future . Non-antibiotic prophylaxis may be used for preventing UTI. Some studies may recommend cranberry juice as prophylaxis of UTI, but there is not any reliable clue to prove its effectiveness . In Linsenmeyer’s study, cranberry was used for prophylaxis of UTI in patients with neurogenic bladder after spinal cord injury. Cranberry tablets could not effectively decrease the risk of UTI in patients with neurogenic bladders .
2.2. Skin and soft tissue infection
One of the most important, serious, and chronic complications of spinal cord injury is pressure ulcer . Pressure ulcers may cause long-term morbidity and even mortality and effectively have severe influence on SCI patients’ lives . These patients have more risk of developing pressure ulcer. The ulcers are often chronic wounds that debilitate the patient and increase hospital course . Pressure ulcers are common in SCI patients and usually are complicated. Treatment is often difficult and expensive. It is important to pay special attention to pressure ulcer in SCI population . Several risk factors are associated with pressure ulcer. These risk factors include: decreased activity, complete cord injury that cause paralysis, cervical collar and back board that cause restricted activity, diabetes mellitus, cigarette smoking, hypoalbuminemia, nursing home residence or long duration hospital stay , loss of sensation, wet area due to urinary or fecal incontinence, poor nutrition, and muscular atrophy. Pressure ulcers usually occur in about 30–40% of SCI patients. Ulcers usually develop on bony prominences. Sacrum, ischial tuberosity, trochanteric area and malleolus are usual areas for developing ulcers . Patients with pressure ulcers may have good outcomes if rapid diagnosis and proper treatment is performed for them. The ulcer may heal completely without any sequelae. Some ulcers may have slow course of healing and some even may not heal. Some studies emphasize on the role of fibronectin on ulcer healing course. Fibronectin may have a role in opsonizing macro-aggregate debris for phagocytosis, increasing revascularization, and facilitating fibroblast proliferation and migration. Plasma fibronectin increases in ulcers with rapid healing but stay in low level in ulcers with poor healing. So plasma fibronectin level may predict the speed of healing of pressure ulcers . The SCI patients may also suffer from other soft tissue infection rather than pressure ulcers including fungal infections and seborrheic dermatitis .
Diagnosis of pressure ulcers is clinical. The ulcer smear and culture can be useful for recognizing the causative organism and determining the antibiotic sensitivity.
Offloading is the cornerstone of treatment of pressure ulcers. Ultrasound (low-frequency and nonthermal) may have a therapeutic role in intact skin ulcers. If the ulcer is superficial, foam dressing and collagenase may be used. For deep pressure ulcers, usually debridement and surgical intervention is needed. Osteomyelitis beneath the ulcer is so important and should be considered in treatment of deep ulcers . In SCI patients, flap surgery may be needed to cover the place of debridement . In Schryvers’s study on large number of SCI patients with pressure ulcers during 20 years, a large number of patients needed surgical intervention. Pelvic area ulcers were the most common (468 of 598 pressure ulcers), of which 431 (92%) were treated surgically. Fasciocutaneous or cutaneous flaps, muscle or musculocutaneous flaps and primary closures were the most common surgical intervention. During the ulcer management, some bone intervention is unavoidable . Medical honey has a substantial efficacy on wound management and control of infection of pressure ulcer, as shown by low bacterial growth, decreased wound size, and improved healing stage .
Electric stimulation therapy (EST) accelerates pressure ulcer healing in SCI patients. Pressure ulcer healing is determined by decrease in wound size and improvement in wound appearance after 3 months of treatment with EST . Use of ultraviolet light C (light wavelength 200–290 nm) may be effective in treatment. It can be because of its potency in killing antibiotic-resistant microorganisms.
Pressure ulcers certainly have a great influence on daily activity and life of SCI patients . The best position and the turning frequency are not clear, but avoiding the 90° lateral position is recommended. This position will bring about high pressure over the trochanters with the risk of pressure ulcer development. The risk of developing pressure ulcer is highly individualized and the SCI patient is at a significant risk. Prevention strategies in seating position and in bed are very important in this group to prevent pressure ulcer, and so, pressure relief maneuvers can be important . Pressure relief, position changes, and regular and frequent observation of skin, especially on the pressure areas, that is, over the bony prominences can prevent pressure ulcer development . Pressure ulcers can also be prevented by improvement of neurologic functions and reducing the time of hospitalization and rehabilitation stay . Pressure ulcer prevention is strongly associated with lifestyle modification . Frequent change of position and use of pressure-relieving devices have important roles in reducing the pressure ulcer development. Some risk factors other than pressure may be important in developing ulcer. In SCI patients who do not have vasomotor control below the level of the lesion, hypoxemia will develop, and it can be an important risk factor. So, pressure ulcers may be prevented not only by reducing external pressure by pressure relief, but also by increasing the patient’s resistance to pressure, by increasing tissue oxygenation . One of the important risk factors that may increase skin and soft tissue infections is resistant bacterial colonization. Some activities such as hand hygiene, contact precautions, and cultural changes are associated with significant declines in bacterial infection, especially MRSA colonization and infection .
One of the complications of spinal cord injury is osteomyelitis. Osteomyelitis may develop by extension of infection from pressure ulcers . After spinal fixation surgery, osteomyelitis may be developed, as a complication of surgery. Osteomyelitis increases the treatment cost and may lead to other complications .
There are several diagnostic methods for diagnosis of osteomyelitis in SCI patients.
Bone biopsy is the gold standard, and magnetic resonance imaging (MRI) is usually used as a sensitive and specific modality. Several organisms are known as causative agents. The most common isolated organisms are
However, Huang’s study demonstrates that MRI is a sensitive method for diagnosis of osteomyelitis in SCI population. MRI can be used to demonstrate the extension of infection and to guide limited surgical resection and preserve viable tissue . Pelvic pressure ulcers that accompany osteomyelitis may show cortical erosion and bone marrow edema in MRI . In SCI patients, abscesses, fluid collections, and sinus tracts can be detected by MRI . For diagnosis of osteomyelitis, gallium scan and plain pelvis X-ray may be used. Negative bone scan can rule out osteomyelitis. However, chronic ulcers usually accompany osteomyelitis. Delayed healing or recurrence of pressure ulcers has no clear association with osteomyelitis . Computerized tomography and Technetium-99 m bone scans are not usually used for diagnosis of osteomyelitis in SCI patients with pressure sores .
Treatment of osteomyelitis is composed of two parts: surgical management and medical treatment. Surgical approach is in fact debridement and in some patients, muscle flap. Medical therapy is in fact antibiotic therapy and wound care. Hyperbaric oxygen may be used in refractory osteomyelitis . Treatment of osteomyelitis is prolonged and so, expensive. Using surgical debridement can shorten the duration of antibiotic therapy for osteomyelitis in SCI patients. In SCI patients with bony prominence osteomyelitis, surgical debridement and flap coverage of the sore can influence the outcome of antibiotic treatment . Antibiotics for treatment are chosen according to the results of culture.
Measures for prevention of osteomyelitis are in fact those that were mentioned in Section 2.3.1 for prevention of pressure ulcer and skin and soft tissue infection. The main preventive measures are pressure relief, regular change of position, and frequent observation of the skin over bony prominences.
Pulmonary complications in SCI patients are important, as they may be life threatening. Pneumonia, pulmonary infarction, pulmonary thromboembolism, chest injury, and atelectasis are the most frequent and important complications in these patients. Pneumonia is one of the most important pulmonary complications. It may have developed shortly after spinal cord injury, during hospitalization or even in rehabilitation periods. The risk of pneumonia is greater in post-injury period. In this phase, the patients usually do not have effective cough. If the phrenic and intercostal nerves have been damaged, the respiration cycle may be influenced and the patients may be prone to pneumonia . After intubation and mechanical ventilation, ventilator-associated pneumonia (VAP) may develop. VAP is in fact the occurrence of pneumonia in patients with mechanical ventilation, occurring more than 48 h after endotracheal intubation . VAP is the most frequent nosocomial infection in patients with mechanical ventilation and is associated with longer intensive care unit stay, longer duration of mechanical ventilation, and high morbidity and mortality .
Pneumonia is diagnosed by signs and symptoms of respiratory infection and according to criteria for diagnosis of nosocomial pneumonia and VAP. By endotracheal culture, the causative organism is found and an antibiotic is chosen according to the result of culture. The most common organisms are
Antibiotics are chosen according to endotracheal secretion culture. For empirical treatment, combination antibiotic therapy is necessary. In this combination, an anti-pseudomonas agent (that is usually effective on other gram negative organisms) such as imipenem, meropenem, piperacillin-tazobactam or cefepime in addition to an aminoglycoside or a quinolone is used. For coverage of Methicillin-resistant
One important risk factor for developing pneumonia is retained secretion. So, pulmonary toilet is important in these patients. Appropriate positioning and cough assistance can be useful for clearing retained secretions. Sometimes early intubation may be necessary to prevent secretion retaining by frequent suctioning . Using effective oral care with antiseptics is associated with the reduction of the incidence of ventilator-associated pneumonia. Oral care solutions have been widely used to prevent ventilator-associated pneumonia . Routine cleaning and disinfection of ventilators can play an important role in VAP prevention and management approach .
2.5. Other infections
Blood stream infection secondary to urinary tract infections, pneumonia, pressure ulcers , catheter-related bloodstream infections , and infections at other sites may occur in SCI patients. Meningitis may occur after penetrating injuries or as a result of CSF leakage at the time of injury or subsequent to surgery . Epidural abscess and subdural empyema can be developed with the same mechanisms. Ventilator-associated tracheobronchitis (VAT) is an infective complication of mechanical ventilation and is a part of the spectrum of ventilator-associated respiratory infections .
Infectious diseases after spinal cord injury are important and should be considered in patients with fever and other signs and symptoms of infections. Appropriate approach, diagnosis, and treatment and surgical interventions, if needed, can be lifesaving and can decrease mortality and morbidity.
With special thanks to Dr. Hadi Niknam, my dear neurosurgeon colleague, and Mrs. Shadi Nasrizadeh Moghaddam.
Mawson AR, Biundo JJ Jr, Neville P, Linares HA, Winchester Y, Lopez A. Risk factors for early occurring pressure ulcers following spinal cord injury. American Journal of Physical Medicine & Rehabilitation. 1988; 67(3):123-127
Hoff JM, Bjerke LW, Gravem PE, Hagen EM, Rekand T. Pressure ulcers after spinal cord injury. Tidsskrift for den Norske Lægeforening. 2012; 132(7):838-839
Lehman CA. Risk factors for pressure ulcers in the spinal cord injured in the community. SCI Nursing. 1995; 12(4):110-114
Sachdeva D, Singh D, Loomba P, Kaur A, Tandon M, Bishnoi I. Assessment of surgical risk factors in the development of ventilator-associated pneumonia in neurosurgical intensive care unit patients: Alarming observations. Neurology India. 2017; 65(4):779-784
Chacko R, Rajan A, Lionel P, Thilagavathi M, Yadav B, Premkumar J. Oral decontamination techniques and ventilator-associated pneumonia. The British Journal of Nursing. 2017; 26(11):594-599
Dinh A, Saliba M, Saadeh D, Bouchand F, Descatha A, Roux AL, Davido B, Clair B, Denys P, Annane D, Perronne C, Bernard L. Blood stream infections due to multidrug-resistant organisms among spinal cord-injured patients, epidemiology over 16 years and associated risks: A comparative study. Spinal Cord. 2016; 54(9):720-725
Adrie C, Garrouste-Orgeas M, Ibn Essaied W, Schwebel C, Darmon M, Mourvillier B, Ruckly S, Dumenil AS, Kallel H, Argaud L, Marcotte G, Barbier F, Laurent V, Goldgran-Toledano D, Clec’h C, Azoulay E, Souweine B, Timsit JF. Attributable mortality of ICU-acquired bloodstream infections: Impact of the source, causative micro-organism, resistance profile and antimicrobial therapy. The Journal of Infection. 2017; 74(2):131-141
Shindo Y, Hasegawa Y. Regional differences in antibiotic-resistant pathogens in patients with pneumonia: Implications for clinicians. Respirology. 2017; 22(8):1536-1546
Biering-Sorensen F, Bagi P, Hoiby N. Urinary tract infections in patients with spinal cord lesions: Treatment and prevention. Drugs. 2001; 61(9):1275-1287
Tofte N, Nielsen AC, Trøstrup H, Andersen CB, Von Linstow M, Hansen B, Biering-Sorensen F, Hoiby N, Moser C. Chronic urinary tract infections in patients with spinal cord lesions—Biofilm infection with need for long-term antibiotic treatment. APMIS. 2017; 125(4):385-391
Siroky MB. Pathogenesis of bacteriuria and infection in the spinal cord injured patient. The American Journal of Medicine. 2002; 113(Suppl 1A):67S-79S
Bossa L, Kline K, McDougald D, Lee BB, Rice SA. Urinary catheter-associated microbiota change in accordance with treatment and infection status. PLoS One. 2017; 12(6):e0177633. DOI: 10.1371/journal.pone.0177633. eCollection 2017
Moola S, Konno R. A systematic review of the management of short-term indwelling urethral catheters to prevent urinary tract infections. JBI Library of Systematic Reviews. 2010; 8(17):695-729
National Institute On Disability And Rehabilitation Research. Prevention and management of urinary tract infections among people with SCI: Consensus statement. NeuroRehabilitation. 1994; 4(4):222-236
García Leoni ME, Esclarín De Ruz A. Management of urinary tract infection in patients with spinal cord injuries. Clinical Microbiology and Infection. 2003; 9(8):780-785
Lee BB, Toh SL, Ryan S, Simpson JM, Clezy K, Bossa L, Rice SA, Marial O, Weber G, Kaur J, Boswell-Ruys C, Goodall S, Middleton J, Tudehope M, Kotsiou G. Probiotics versus placebo as prophylaxis for urinary tract infection in persons with spinal cord injury: A study protocol for a randomised controlled trial. BMC Urology. 2016; 16:18
Tenke P, Kovacs B, Bjerklund Johansen TE, Matsumoto T, Tambyah PA, Naber KG. European and Asian guidelines on management and prevention of catheter-associated urinary tract infections. International Journal of Antimicrobial Agents. 2008; 31(Suppl 1):S68-S78
Cardenas DD, Moore KN, Dannels-McClure A, Scelza WM, Graves DE, Brooks M, Busch AK. Intermittent catheterization with a hydrophilic-coated catheter delays urinary tract infections in acute spinal cord injury: A prospective, randomized, multicenter trial. PM & R. 2011; 3(5):408-417
Nicolle LE. Catheter-related urinary tract infection. Drugs & Aging. 2005; 22(8):627-639
Darouiche RO, Al Mohajer M, Siddiq DM, Minard CG. Short versus long course of antibiotics for catheter-associated urinary tract infections in patients with spinal cord injury: A randomized controlled noninferiority trial. Archives of Physical Medicine and Rehabilitation. 2014; 95(2):290-296
Linsenmeyer TA, Harrison B, Oakley A, Kirshblum S, Stock JA, Millis SR. Evaluation of cranberry supplement for reduction of urinary tract infections in individuals with neurogenic bladders secondary to spinal cord injury. A prospective, double-blinded, placebo-controlled, crossover study. The Journal of Spinal Cord Medicine. 2004; 27(1):29-34
Guihan M, Bombardier CH. Potentially modifiable risk factors among veterans with spinal cord injury hospitalized for severe pressure ulcers: A descriptive study. The Journal of Spinal Cord Medicine. 2012; 35(4):240-250
Sunn G. Spinal cord injury pressure ulcer treatment: An experience-based approach. Physical Medicine and Rehabilitation Clinics of North America. 2014; 25(3):671-680
Dana AN, Bauman WA. Bacteriology of pressure ulcers in individuals with spinal cord injury: What we know and what we should know. The Journal of Spinal Cord Medicine. 2015; 38(2):147-160
Biglari B, Büchler A, Reitzel T, Swing T, Gerner HJ, Ferbert T, Moghaddam A. A retrospective study on flap complications after pressure ulcer surgery in spinal cord-injured patients. Spinal Cord. 2014; 52(1):80-83
Salzberg CA, Byrne DW, Cayten CG, van Niewerburgh P, Murphy JG, Viehbeck M. A new pressure ulcer risk assessment scale for individuals with spinal cord injury. American Journal of Physical Medicine & Rehabilitation. 1996; 75(2):96-104
Vaziri ND, Eltorai I, Gonzales E, Winer RL, Pham H, Bui TD, Said S. Pressure ulcer, fibronectin, and related proteins in spinal cord injured patients. Archives of Physical Medicine and Rehabilitation. 1992; 73(9):803-806
Han ZA, Choi JY, Ko YJ. Dermatological problems following spinal cord injury in Korean patients. The Journal of Spinal Cord Medicine. 2015; 38(1):63-67
Schryvers OI, Stranc MF, Nance PW. Surgical treatment of pressure ulcers: 20-year experience. Archives of Physical Medicine and Rehabilitation. 2000; 81(12):1556-1562
Biglari B, Linden PH, Simon A, Aytac S, Gerner HJ, Moghaddam A. Use of Medihoney as a non-surgical therapy for chronic pressure ulcers in patients with spinal cord injury. Spinal Cord. 2012; 50(2):165-169
Houghton PE, Campbell KE, Fraser CH, Harris C, Keast DH, Potter PJ, Hayes KC, Woodbury MG. Electrical stimulation therapy increases rate of healing of pressure ulcers in community-dwelling people with spinal cord injury. Archives of Physical Medicine and Rehabilitation. 2010; 91(5):669-678
Thai TP, Keast DH, Campbell KE, Woodbury MG, Houghton PE. Effect of ultraviolet light C on bacterial colonization in chronic wounds. Ostomy/Wound Management. 2005; 51(10):32-45
Sherman RA, Wyle F, Vulpe M. Maggot therapy for treating pressure ulcers in spinal cord injury patients. The Journal of Spinal Cord Medicine. 1995; 18(2):71-74
Lala D, Dumont FS, Leblond J, Houghton PE, Noreau L. Impact of pressure ulcers on individuals living with a spinal cord injury. Archives of Physical Medicine and Rehabilitation. 2014; 95(12):2312-2319
Groah SL, Schladen M, Pineda CG, Hsieh CH. Prevention of pressure ulcers among people with spinal cord injury: A systematic review. PM &R. 2015; 7(6):613-636
Celani MG, Spizzichino L, Ricci S, Zampolini M, Franceschini M. Spinal cord injury in Italy: A multicenter retrospective study. Archives of Physical Medicine and Rehabilitation. 2001; 82(5):589-596
Mawson AR, Siddiqui FH, Biundo JJ Jr. Enhancing host resistance to pressure ulcers: A new approach to prevention. Preventive Medicine. 1993; 22(3):433-450
Eltorai I, Hart GB, Strauss MB. Osteomyelitis in the spinal cord injured: A review and a preliminary report on the use of hyperbaric oxygen therapy. Paraplegia. 1984; 22(1):17-24
Rennert R, Golinko M, Yan A, Flattau A, Tomic-Canic M, Brem H. Developing and evaluating outcomes of an evidence-based protocol for the treatment of osteomyelitis in Stage IV pressure ulcers: A literature and wound electronic medical record database review. Ostomy/Wound Management. 2009; 55(3):42-53
Brunel AS, Lamy B, Cyteval C, Perrochia H, Téot L, Masson R, Bertet H, Bourdon A, Morquin D, Reynes J, Le Moing V. Diagnosing pelvic osteomyelitis beneath pressure ulcers in spinal cord injured patients: A prospective study. Clinical Microbiology Infection. 2016; 22(3):267
Huang AB, Schweitzer ME, Hume E, Batte WG. Osteomyelitis of the pelvis/hips in paralyzed patients: Accuracy and clinical utility of MRI. Journal of Computer Assisted Tomography. 1998; 22(3):437-443
Hauptfleisch J, Meagher TM, Hughes RJ, Singh JP, Graham A, López de Heredia L. Interobserver agreement of magnetic resonance imaging signs of osteomyelitis in pelvic pressure ulcers in patients with spinal cord injury. Archives of Physical Medicine and Rehabilitation. 2013; 94(6):1107-1111
Ruan CM, Escobedo E, Harrison S, Goldstein B. Magnetic resonance imaging of nonhealing pressure ulcers and myocutaneous flaps. Archives of Physical Medicine and Rehabilitation. 1998; 79(9):1080-1088
Thornhill-Joynes M, Gonzales F, Stewart CA, Kanel GC, Lee GC, Capen DA, Sapico FL, Canawati HN, Montgomerie JZ. Osteomyelitis associated with pressure ulcers. Archives of Physical Medicine and Rehabilitation. 1986; 67(5):314-318
Lewis VL, Bailey MH, Pulawski G, Kind G, Bashioum RW, Hendrix RW. The diagnosis of osteomyelitis in patients with pressure sores. Plastic and Reconstructive Surgery. 1988; 81(2):229-232
Deloach ED, DiBenedetto RJ, Womble L, Gilley JD. The treatment of osteomyelitis underlying pressure ulcers. Decubitus. 1992; 5(6):32-41
Marriott R, Rubayi S. Successful truncated osteomyelitis treatment for chronic osteomyelitis secondary to pressure ulcers in spinal cord injury patients. Annals of Plastic Surgery. 2008; 61(4):425-429
John Z. Montgomerie. Infections in patients with spinal cord injuries. Clinical Infectious Diseases. 1997; 25:1285-1292
Zhang Z, Hou Y, Zhang J, Wang B, Zhang J, Yang A, Li G, Tian J. Comparison of the effect of oral care with four different antiseptics to prevent ventilator-associated pneumonia in adults: Protocol for a network meta-analysis. Systmatic Review. 2017; 6(1):103
Ergul AB, Cetin S, Altintop YA, Bozdemir SE, Ozcan A, Altug U, Samsa H, Torun YA. Evaluation of microorganisms causing ventilator-associated pneumonia in a pediatric intensive care unit. The Eurasian Journal of Medicine. 2017; 49(2):87-91
Souza LCD, Mota VBRD, Carvalho AVDSZ, Corrêa RDGCF, Libério SA, Lopes FF. Association between pathogens from tracheal aspirate and oral biofilm of patients on mechanical ventilation. Brazilian Oral Research. 2017; 31:e3
Kollef MH, Burnham CD. Ventilator-associated pneumonia: The role of emerging diagnostic technologies. Seminars in Respiratory and Critical Care Medicine. 2017; 38(3):253-263
Guo L, Li G, Wang J, Zhao X, Wang S, Zhai L, Jia H, Cao B. Suspicious outbreak of ventilator-associated pneumonia caused by Burkholderia cepacia in a surgical intensive care unit. American Journal of Infection Control. 2017; 45(6):660-666
Saliba M, Saadeh D, Bouchand F, Davido B, Duran C, Clair B, Lawrence C, Annane D, Denys P, Salomon J, Bernard L, Dinh A. Outcome of bloodstream infections among spinal cord injury patients and impact of multidrug-resistant organisms. Spinal Cord. 2017; 55(2):148-154
Ray U, Ramasubban S, Chakravarty C, Goswami L, Dutta S. A prospective study of ventilator-associated tracheobronchitis: Incidence and etiology in intensive care unit of a tertiary care hospital. Lung India. 2017; 34(3):236-240