Effect of pertinent parameters on heat transfer rate.
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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"11331",leadTitle:null,fullTitle:"Secondary Metabolites - Trends and Reviews",title:"Secondary Metabolites",subtitle:"Trends and Reviews",reviewType:"peer-reviewed",abstract:"This book provides an overview of secondary metabolites in three sections: “Introduction”, “Secondary Metabolites: General Reviews and Biotechnological Interventions” and “Plant Secondary Metabolites.” It discusses the antimicrobial, anticancer, and antioxidant activities of secondary metabolites, biotechnological interventions in the production and research of secondary metabolites, and the secondary metabolites of plants.",isbn:"978-1-80355-208-8",printIsbn:"978-1-80355-207-1",pdfIsbn:"978-1-80355-209-5",doi:null,price:139,priceEur:155,priceUsd:179,slug:"secondary-metabolites-trends-and-reviews",numberOfPages:310,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"7d6274f42d5441e537c5fa744bc84523",bookSignature:"Ramasamy Vijayakumar and Suresh Selvapuram Sudalaimuthu Raja",publishedDate:"August 17th 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11331.jpg",numberOfDownloads:876,numberOfWosCitations:0,numberOfCrossrefCitations:2,numberOfCrossrefCitationsByBook:null,numberOfDimensionsCitations:2,numberOfDimensionsCitationsByBook:null,hasAltmetrics:0,numberOfTotalCitations:4,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"August 26th 2021",dateEndSecondStepPublish:"September 23rd 2021",dateEndThirdStepPublish:"November 22nd 2021",dateEndFourthStepPublish:"February 10th 2022",dateEndFifthStepPublish:"April 11th 2022",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"176044",title:"Dr.",name:"Ramasamy",middleName:null,surname:"Vijayakumar",slug:"ramasamy-vijayakumar",fullName:"Ramasamy Vijayakumar",profilePictureURL:"https://mts.intechopen.com/storage/users/176044/images/system/176044.jpeg",biography:"Dr. Ramasamy Vijayakumar is an assistant professor in the Department of Microbiology, Government Arts and Science College (formerly Bharathidasan University Constituent College), affiliated with Bharathidasan University, Perambalur, India. He has sixteen years of teaching experience as well as twenty years of research experience in the field of actinobacteriology. He has deposited around twenty-one nucleotide sequences in GenBank; published seventy-eight research articles, twelve book chapters, and two books; guided six Ph.D. candidates; and organized several seminars and workshops. He has received research grants from the DBT, TNSCST, and TANSCHE, Government of India. He filed one Indian patent. He is a life member of the National Academy of Biological Sciences, India, Mycological Society of India, and Microbiologist’s Society, India. He is a member of the doctoral committee for Ph.D. scholars and a member of the board of studies for microbiology in various institutions. He received the 2013 Shri P.K. Das Memorial Best Faculty Award in Microbiology from the Nehru Arts and Science College, Coimbatore , India. As per the Indian Journal of Experimental Biology (Vol. 51, 2013), Dr. Vijayakumar was ranked second in the top five institutions in the field of actinobacterial research in India.",institutionString:"Bharathidasan University Constituent College",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Bharathidasan University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"229614",title:"Dr.",name:"Suresh",middleName:"Selvapuram Sudalaimuthu",surname:"Raja",slug:"suresh-raja",fullName:"Suresh Raja",profilePictureURL:"https://mts.intechopen.com/storage/users/229614/images/system/229614.jpeg",biography:"Dr. Suresh S.S. Raja is an assistant professor and head of the Department of Microbiology, Government Arts and Science College (formerly Bharathidasan University Constituent College), affiliated with Bharathidasan University, Perambalur, India. He has been teaching Microbiology both at undergraduate and post-graduate levels for the last twenty-two years. He has published twenty-five research articles in national and international journals and has attended numerous seminars, symposia, and workshops. He has documented seroprevalence of leptospirosis among farming communities in three districts of Tamil Nadu, South India. Medical microbiology remains his field of specialization. He has supervised three student projects funded by the state science academy. He has organized several seminars and training workshops. He is a member of the board of studies of various colleges and one university. He had been a member of a university inspection committee for approving Microbiology courses at colleges. He has delivered special lectures at academic institutions and extension programmes and is a member of professional bodies and voluntary organizations.",institutionString:"Bharathidasan University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Bharathidasan University",institutionURL:null,country:{name:"India"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"43",title:"Biochemistry",slug:"biochemistry-genetics-and-molecular-biology-biochemistry"}],chapters:[{id:"81153",title:"Introductory Chapter: Secondary Metabolites - An Overview",doi:"10.5772/intechopen.104234",slug:"introductory-chapter-secondary-metabolites-an-overview",totalDownloads:2,totalCrossrefCites:null,totalDimensionsCites:null,hasAltmetrics:null,abstract:null,signatures:"Girish Nair, Suresh Selvapuram Sudalaimuthu Raja and Ramasamy Vijayakumar",downloadPdfUrl:"/chapter/pdf-download/81153",previewPdfUrl:"/chapter/pdf-preview/81153",authors:[{id:"176044",title:"Dr.",name:"Ramasamy",surname:"Vijayakumar",slug:"ramasamy-vijayakumar",fullName:"Ramasamy Vijayakumar"},{id:"458357",title:"Dr.",name:"Suresh Selvapuram",surname:"Sudalaimuthu Raja",slug:"suresh-selvapuram-sudalaimuthu-raja",fullName:"Suresh Selvapuram Sudalaimuthu Raja"},{id:"458358",title:"Dr.",name:"Girish",surname:"Nair",slug:"girish-nair",fullName:"Girish Nair"}],corrections:null},{id:"80358",title:"Diverse Survival Functions of Secondary Metabolites in Nature",doi:"10.5772/intechopen.101977",slug:"diverse-survival-functions-of-secondary-metabolites-in-nature",totalDownloads:112,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Secondary metabolites are low molecular mass products of secondary metabolism which are usually produced by microorganisms experiencing stringent conditions. These metabolites are not essential for growth but serve diverse survival functions in nature. Besides offering survival advance to the producing organisms, they have several medicinal uses such as antibiotics, chemotherapeutic drugs, immune suppressants, and other medicines which benefited human society immensely for more than a century. This chapter provides an overview of various functions these secondary metabolites offer in nature from single-cell organisms to multicellular organisms. Furthermore, this chapter also discusses the underlying mechanisms behind their diverse functions and how these are regulated and synthesized under non-viable environmental conditions.",signatures:"Ayush Mandwal",downloadPdfUrl:"/chapter/pdf-download/80358",previewPdfUrl:"/chapter/pdf-preview/80358",authors:[{id:"438225",title:"Ph.D. Student",name:"Ayush",surname:"Mandwal",slug:"ayush-mandwal",fullName:"Ayush Mandwal"}],corrections:null},{id:"79930",title:"Secondary Metabolites: The Natural Remedies",doi:"10.5772/intechopen.101791",slug:"secondary-metabolites-the-natural-remedies",totalDownloads:96,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The chapter discusses the meaning and origin of some important classes of secondary metabolites such as alkaloids, terpenoids, tannins, flavonoids, saponins, glycosides, and phenolic compounds, etc., produced by some bacteria, fungi, or plants. Very important drugs that are used clinically are derived from these secondary metabolites. Several reports obtained in scientific journals and books written by different scientists working or who have worked in the fields of natural products medicine were reviewed. These different classes of secondary metabolites have shown activity against varied diseases, and compounds that are of novel structure and activity have been isolated and characterized from them. The chapter highlights the economic impacts of these chemical compounds including their role in improving human and animal health and well-being by serving as sources of some antibiotics, anticancer, anti-inflammatory, antifertility, antidiabetics, analgesics, growth promoters, etc. Secondary metabolites are also used to enhance agricultural productivity, they find uses as pesticides, insecticides, and preservatives. Some folkloric uses of secondary metabolites chemical compounds based on reliable sources of information and genuine scientific investigations are highlighted.",signatures:"Hudu Garba Mikail, Mamman Mohammed, Habib Danmalam Umar and Mohammed Musa Suleiman",downloadPdfUrl:"/chapter/pdf-download/79930",previewPdfUrl:"/chapter/pdf-preview/79930",authors:[{id:"70365",title:"Dr.",name:"Hudu",surname:"Garba Mikail",slug:"hudu-garba-mikail",fullName:"Hudu Garba Mikail"},{id:"314244",title:"Prof.",name:"Mamman",surname:"Mohammed",slug:"mamman-mohammed",fullName:"Mamman Mohammed"},{id:"437101",title:"Prof.",name:"Habib",surname:"Danmalam Umar",slug:"habib-danmalam-umar",fullName:"Habib Danmalam Umar"},{id:"437103",title:"Prof.",name:"Mohammed",surname:"Musa Suleiman",slug:"mohammed-musa-suleiman",fullName:"Mohammed Musa Suleiman"}],corrections:null},{id:"80477",title:"Secondary Metabolites from Natural Products",doi:"10.5772/intechopen.102222",slug:"secondary-metabolites-from-natural-products",totalDownloads:143,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Natural products are substances that are confined from living organisms, they are in the form of primary or secondary metabolites. Secondary metabolites are compounds with varied chemical structures, produced by some plants and strains of microbial species. Unlike primary metabolites (nucleotides, amino acids, carbohydrates, and lipids) that are essential for growth, secondary metabolites are not. Secondary metabolites are produced or synthesized during the stationary stage. In this chapter, we will discuss secondary metabolites from natural products synthesized mainly by plants, fungi, and bacteria. Plants synthesize a large diversity of secondary metabolites; plant secondary metabolites are split into four groups namely alkaloids, phenolic compounds, terpenoids, and glucosinolates. Several classes of fungal and bacterial secondary metabolites, their sources, and pharmacological uses associated with the secondary metabolites are also discussed. Therefore, several classes of secondary metabolites are responsible for the biological and pharmacological activities of plants and herbal medicines.",signatures:"Stella Omokhefe Bruce",downloadPdfUrl:"/chapter/pdf-download/80477",previewPdfUrl:"/chapter/pdf-preview/80477",authors:[{id:"341144",title:"Dr.",name:"Stella Omokhefe",surname:"Bruce",slug:"stella-omokhefe-bruce",fullName:"Stella Omokhefe Bruce"}],corrections:null},{id:"81044",title:"Metabolomics and Genetic Engineering for Secondary Metabolites Discovery",doi:"10.5772/intechopen.102838",slug:"metabolomics-and-genetic-engineering-for-secondary-metabolites-discovery",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Since 1940s, microbial secondary metabolites (SMs) have attracted the attention of the scientific community. As a result, intensive researches have been conducted in order to discover and identify novel microbial secondary metabolites. Since, the discovery of novel secondary metabolites has been decreasing significantly due to many factors such as 1) unculturable microbes 2) traditional detection techniques 3) not all SMs expressed in the lab. As a result, searching for new techniques which can overcome the previous challenges was one of the most priority objectives. Therefore, the development of omics-based techniques such as genomics and metabolomic have revealed the potential of discovering novel SMs which were coded in the microorganisms’ DNA but not expressed in the lab or might be produced in undetectable amount by detecting the biosynthesis gene clusters (BGCs) that are associated with the biosynthesis of secondary metabolites. Nowadays, the integration of metabolomics and gene editing techniques such as CRISPR-Cas9 provide a successful platform for the detection and identification of known and unknown secondary metabolites also to increase secondary metabolites production.",signatures:"Ahmed M. Shuikan, Wael N. Hozzein, Rakan M. Alshuwaykan and Ibrahim A. Arif",downloadPdfUrl:"/chapter/pdf-download/81044",previewPdfUrl:"/chapter/pdf-preview/81044",authors:[{id:"189233",title:"Prof.",name:"Wael N.",surname:"Hozzein",slug:"wael-n.-hozzein",fullName:"Wael N. Hozzein"},{id:"302440",title:"Dr.",name:"Ahmed M.",surname:"Shuikan",slug:"ahmed-m.-shuikan",fullName:"Ahmed M. Shuikan"},{id:"446244",title:"Prof.",name:"Ibrahim A.",surname:"Arif",slug:"ibrahim-a.-arif",fullName:"Ibrahim A. Arif"},{id:"452310",title:"MSc.",name:"Rakan M.",surname:"Alshuwaykan",slug:"rakan-m.-alshuwaykan",fullName:"Rakan M. Alshuwaykan"}],corrections:null},{id:"80072",title:"In Vitro Cultures for the Production of Secondary Metabolites",doi:"10.5772/intechopen.101880",slug:"-em-in-vitro-em-cultures-for-the-production-of-secondary-metabolites",totalDownloads:75,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Plants’ secondary metabolism is an important source of medicinal and industrial products. Even though natural ecosystems are still the most important font of this kind of substance, excessive harvesting of spontaneous flora can act as a direct cause of biodiversity loss. Different technologies are used for in vitro production which, in addition to being useful for safeguarding biodiversity, make available to industry substances that are difficult to produce in vivo. Moreover, the growing demand for secondary metabolites encourages the use of new biotechnology tools to create new, more productive in vitro transgenic plant cultures.",signatures:"Grazia Maria Scarpa, Vanda Prota, Nicola Schianchi and Federica Manunta",downloadPdfUrl:"/chapter/pdf-download/80072",previewPdfUrl:"/chapter/pdf-preview/80072",authors:[{id:"436662",title:"Prof.",name:"Grazia Maria",surname:"Scarpa",slug:"grazia-maria-scarpa",fullName:"Grazia Maria Scarpa"},{id:"436665",title:"Prof.",name:"Vanda",surname:"Prota",slug:"vanda-prota",fullName:"Vanda Prota"},{id:"436666",title:"Dr.",name:"Nicola",surname:"Schianchi",slug:"nicola-schianchi",fullName:"Nicola Schianchi"},{id:"436667",title:"Dr.",name:"Federica",surname:"Manunta",slug:"federica-manunta",fullName:"Federica Manunta"}],corrections:null},{id:"80596",title:"Biological Activity of Defence-Related Plant Secondary Metabolites",doi:"10.5772/intechopen.101379",slug:"biological-activity-of-defence-related-plant-secondary-metabolites",totalDownloads:64,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The message that everyone needs to know is that secondary metabolites in plants and natural products are involved in various activities. The phenolics, quinones, terpenes, flavonoids, and other thousands of low molecular weight metabolites activity is unknown. Well-understood secondary metabolites have been implicated in the defense against pathogens; the operating system of some of these has been established. In particular, to date, a relatively small number of processes have been shown to be targets of plant metabolism, including electron transport chains, mitochondrial function, and membrane integration. However, it is now emerging that other specific enzymes and processes may also be targets of specific metabolites. There is a general belief that modern genetic approaches will identify new targets and mechanisms of plant metabolism. Molecules that trigger apoptosis or autoimmunity in tumor cells, especially triterpenoids, are of particular interest in this regard. Before proceeding to specific studies in plant or human cells, we discuss whether there is a case for conducting preliminary studies on the mechanism of action in the genetic pathway system, such as yeast Saccharomyces cerevisiae, considering the approaches taken so far in botany and strategies that have led to success in the biomedical field.",signatures:"Ananth Anbu and Umadevi Ananth",downloadPdfUrl:"/chapter/pdf-download/80596",previewPdfUrl:"/chapter/pdf-preview/80596",authors:[{id:"438749",title:"Dr.",name:"Ananth",surname:"Anbu",slug:"ananth-anbu",fullName:"Ananth Anbu"},{id:"438822",title:"Mrs.",name:"Umadevi",surname:"Ananth",slug:"umadevi-ananth",fullName:"Umadevi Ananth"}],corrections:null},{id:"82403",title:"Use of Plant Secondary Metabolites to Reduce Crop Biotic and Abiotic Stresses: A Review",doi:"10.5772/intechopen.104553",slug:"use-of-plant-secondary-metabolites-to-reduce-crop-biotic-and-abiotic-stresses-a-review",totalDownloads:23,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Plant secondary metabolites (PSM) are small molecules of organic compounds produced in plant metabolism that have various ecological functions, such as defense against pathogens, herbivores, and neighboring plants. They can also help to reduce abiotic stresses, such as drought, salinity, temperature, and UV. This chapter reviewed the ecological functions of the PSM and how people utilize these metabolites to reduce crop biotic and abiotic stresses in agriculture. Specific topics covered in this review are (1) extraction of PSM from plant parts and its application on crops; (2) screening of crop/cover crop germplasms for high PSM content and with resistance to pathogens, herbivores, and/or neighboring plants; (3) regulation of PSM biosynthesis (including plant hormones and defense activators) to increase plant readiness for defense; (4) transcriptome and genome technology improvements in the last decade leading to valuable tools to characterize differential gene expression and gene composition in a genome, and lineage-specific gene family expansion and contraction. In addition, there is a critical need to understand how the biosynthesis and release of allelochemicals occur. Filling this knowledge gap will help us to improve and encourage sustainable weed control practices in agriculture.",signatures:"Ziming Yue, Varsha Singh, Josiane Argenta, Worlanyo Segbefia, Alyssa Miller and Te Ming Tseng",downloadPdfUrl:"/chapter/pdf-download/82403",previewPdfUrl:"/chapter/pdf-preview/82403",authors:[{id:"215085",title:"Dr.",name:"Te Ming",surname:"Tseng",slug:"te-ming-tseng",fullName:"Te Ming Tseng"},{id:"437167",title:"Dr.",name:"Ziming",surname:"Yue",slug:"ziming-yue",fullName:"Ziming Yue"},{id:"486475",title:"Dr.",name:"Varsha",surname:"Singh",slug:"varsha-singh",fullName:"Varsha Singh"},{id:"486476",title:"Dr.",name:"Josiane",surname:"Argenta",slug:"josiane-argenta",fullName:"Josiane Argenta"},{id:"486477",title:"Dr.",name:"Worlanyo",surname:"Segbefia",slug:"worlanyo-segbefia",fullName:"Worlanyo Segbefia"},{id:"486478",title:"Dr.",name:"Alyssa",surname:"Miller",slug:"alyssa-miller",fullName:"Alyssa Miller"}],corrections:null},{id:"81233",title:"Secondary Metabolites of Fruits and Vegetables with Antioxidant Potential",doi:"10.5772/intechopen.103707",slug:"secondary-metabolites-of-fruits-and-vegetables-with-antioxidant-potential",totalDownloads:45,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"An antioxidant is of great interest among researchers, scientists, nutritionists, and the public because of its ability to prevent oxidative damage, as indicated by various studies. This chapter mainly focuses on the free radicals and their types; antioxidants and their mode of action against free radicals; fruits, vegetables, and their byproducts as a source of antioxidants; and various analytical methods employed for assessing antioxidant activity. Antioxidants discussed in this chapter are ascorbic acid, Vitamin E, carotenoids and polyphenols, and their mechanism of action. Different antioxidant activity assay techniques have been reported. Fruits and vegetables are abundant sources of these secondary metabolites. The waste generated during processing has many bioactive materials, which possibly be used in value-added by-products.",signatures:"Ravneet Kaur, Shubhra Shekhar and Kamlesh Prasad",downloadPdfUrl:"/chapter/pdf-download/81233",previewPdfUrl:"/chapter/pdf-preview/81233",authors:[{id:"228359",title:"Prof.",name:"Kamlesh",surname:"Prasad",slug:"kamlesh-prasad",fullName:"Kamlesh Prasad"},{id:"466183",title:"Dr.",name:"Ravneet",surname:"Kaur",slug:"ravneet-kaur",fullName:"Ravneet Kaur"},{id:"466184",title:"Dr.",name:"Shubhra",surname:"Shekhar",slug:"shubhra-shekhar",fullName:"Shubhra Shekhar"}],corrections:null},{id:"80708",title:"Cytotoxicity and Antitumor Action of Lignans and Neolignans",doi:"10.5772/intechopen.102223",slug:"cytotoxicity-and-antitumor-action-of-lignans-and-neolignans",totalDownloads:62,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Lignans and neolignans are plant’s secondary metabolites, widely distributed in the plant kingdom, and have been identified in more than 70 plant families. These compounds are mainly localized in lignified tissues, seeds, and roots. Lignans and neolignans present a great variety of biological activities, such as antioxidant, anti-inflammatory, antineurodegenerative, antiviral, antimicrobial, and antitumor. By 2040, it is estimated that the number of new cancer cases per year will rise to 29.5 million; therefore, the development of new anticancer agents and adjuvants is essential. Lignans and neolignans have also indicated a reduction in the risk of cancer at different stages. The objective of this review is to search and analyze the cytotoxic and antitumor activity of lignans and neolignans that can be an important source of new antitumor drugs. We have made a comprehensive summary of 113 lignans and neolignans, obtained from 44 plants and divided between 34 families, which demonstrated cytotoxic activity in several human cancer cell lines evaluated through various in vitro studies and other in vivo models, by inducing mitochondrial apoptosis and cell cycle arrest, inhibiting NF-κβ activity and activation of metalloproteinases (MMPs), among other processes. Overall, 13 compounds, methoxypinoresinol, arctigenin, trachelogenin, 4-O-methylhonokiol, honokiol, bifidenone, (−)-trachelogeninit, deoxypodophyllotoxin, matairesinol, bejolghotin G, H, and I, and hedyotol-B, showed the best anticancer activity.",signatures:"Ana Laura Esquivel-Campos, Salud Pérez-Gutiérrez, Leonor Sánchez-Pérez, Nimsi Campos-Xolalpa and Julia Pérez-Ramos",downloadPdfUrl:"/chapter/pdf-download/80708",previewPdfUrl:"/chapter/pdf-preview/80708",authors:[{id:"224593",title:"Dr.",name:"Salud",surname:"Pérez-Gutiérrez",slug:"salud-perez-gutierrez",fullName:"Salud Pérez-Gutiérrez"},{id:"287823",title:"Dr.",name:"Nimsi",surname:"Campos-Xolalpa",slug:"nimsi-campos-xolalpa",fullName:"Nimsi Campos-Xolalpa"},{id:"287826",title:"Dr.",name:"Julia",surname:"Pérez-Ramos",slug:"julia-perez-ramos",fullName:"Julia Pérez-Ramos"},{id:"345657",title:"Dr.",name:"Leonor",surname:"Sánchez-Pérez",slug:"leonor-sanchez-perez",fullName:"Leonor Sánchez-Pérez"},{id:"404153",title:"Dr.",name:"Ana Laura",surname:"Esquivel-Campos",slug:"ana-laura-esquivel-campos",fullName:"Ana Laura Esquivel-Campos"}],corrections:null},{id:"81728",title:"Plant Secondary Metabolites: Therapeutic Potential and Pharmacological Properties",doi:"10.5772/intechopen.103698",slug:"plant-secondary-metabolites-therapeutic-potential-and-pharmacological-properties",totalDownloads:35,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Plants are an essential source for discovering novel medical compounds for drug development, and secondary metabolites are sources of medicines from plants. Secondary metabolites include alkaloids, flavonoids, terpenoids, tannins, coumarins, quinones, carotenoids, and steroids. Each year, several new secondary metabolites are extracted from plants, providing a source of possibilities to investigate against malignant illnesses, despite certain natural chemicals having distinct anticancer activities according to their physicochemical features. Secondary metabolites found in plants are frequently great leads for therapeutic development. However, changes in the molecular structure of these compounds are improving their anticancer activity and selectivity and their absorption, distribution, metabolism, and excretion capacities while minimizing their toxicity and side effects. In this section, we will discuss the most significant breakthroughs in the field of plant secondary metabolites, some of which are currently in clinical use and others that are in clinical trials as anticancer drugs. This study gives an up-to-date and thorough summary of secondary plant metabolites and their antioxidant, antibacterial, and anticancer effects. Furthermore, antioxidant and antibacterial, and anticancer effects of secondary metabolites are addressed. As a result, this article will serve as a thorough, quick reference for people interested in secondary metabolite antioxidants, anticancer, and antibacterial properties.",signatures:"Muhammad Zeeshan Bhatti, Hammad Ismail and Waqas Khan Kayani",downloadPdfUrl:"/chapter/pdf-download/81728",previewPdfUrl:"/chapter/pdf-preview/81728",authors:[{id:"345782",title:"Dr.",name:"Muhammad Zeeshan",surname:"Bhatti",slug:"muhammad-zeeshan-bhatti",fullName:"Muhammad Zeeshan Bhatti"},{id:"453006",title:"Dr.",name:"Hammad",surname:"Ismail",slug:"hammad-ismail",fullName:"Hammad Ismail"},{id:"453007",title:"Dr.",name:"Waqas Khan",surname:"Kayani",slug:"waqas-khan-kayani",fullName:"Waqas Khan Kayani"}],corrections:null},{id:"80446",title:"Chiral Inversion of Active Compounds in Plant Extract",doi:"10.5772/intechopen.102537",slug:"chiral-inversion-of-active-compounds-in-plant-extract",totalDownloads:50,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Chiral inversion is always mediated by enzymes and varies with solvent, pH and temperature. Considerable attention should be paid to the mechanism of the inversion reaction and its pharmacological and toxicological results. This chapter will discuss the mechanism of chiral inversion of plants in secondary metabolize and its importance in creating pharmacology consequences. Plant stereoisomers of alkaloids and flavonoids exhibit a wide range of pharmacological effects. Recent advances in chiral analysis for the herbal plants in clinical research & forensic toxicology by experiments in which one enantiomer was given to the experiment subjects in a specific situation. Demonstration of metabolic chiral inversion may have consequences for the development of a new pharmaceutical entity. Hence, it helps a better understanding of chiral compounds in plants, facilitating the application for drug development from medicinal herbs and thereby reducing bioanalytical and toxicology workload.",signatures:"Ngoc-Van Thi Nguyen",downloadPdfUrl:"/chapter/pdf-download/80446",previewPdfUrl:"/chapter/pdf-preview/80446",authors:[{id:"336695",title:"Associate Prof.",name:"Ngoc-Van Thi",surname:"Nguyen",slug:"ngoc-van-thi-nguyen",fullName:"Ngoc-Van Thi Nguyen"}],corrections:null},{id:"80527",title:"Secondary Metabolites of Edible Cacti (Cactaceae) from the South American Andes",doi:"10.5772/intechopen.102419",slug:"secondary-metabolites-of-edible-cacti-cactaceae-from-the-south-american-andes",totalDownloads:105,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The South American Andes hide countless cacti and are part of valuable Andean biodiversity. Within this large family of Cactaceae are edible cacti that are highly valued for their medicinal properties and used as edible fruits. In this review, we will make a description of the overall chemical composition, main phytochemicals found in some edible cacti of the Andean region such as sanky (Corryocactus brevistylus), pitahaya (Hylocereus monacanthus, Hylocereus megalanthus) and tuna or prickly pear (Opuntia ficus-indica). In addition, we will include its medicinal and therapeutic properties and its commercial applications and uses as a natural colorant.",signatures:"Frank L. 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Polyphenols are secondary metabolites which protect plants from different pathogens, such as viruses, bacteria, fungi, insects, and herbivores. Currently, about 9000 polyphenols found in more than 480 plants are known. Their amount fluctuates across different species and varieties. This chapter describes conventional and novel methods for extraction, the influence of the type of solvents, solvent concentration and temperature on the yield. The highest yield is obtained at 70% of methanol and ethanol, and at 90% of acetone. Extraction at 80°C leads to higher amounts of polyphenols than extraction at 100°C. Polyphenols are usually metabolized in the human liver but can also remain unaffected as they pass through the gastrointestinal tract. The main location for their uptake is the colon. They exhibit a wide range of antibacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus epidermidis, Klebsiella pneumoniae, E. coli, Listeria monocytogenes, Acinetobacter sp., Proteus sp., Micrococcus sp., and Bacillus sp. All these plants, rich in antimicrobial polyphenols, represent a promising and powerful source of highly effective novel antibacterial substances in the current era of ubiquitous antibiotic resistance.",signatures:"Galina Satchanska",downloadPdfUrl:"/chapter/pdf-download/80080",previewPdfUrl:"/chapter/pdf-preview/80080",authors:[{id:"354552",title:"Associate Prof.",name:"Galina",surname:"Satchanska",slug:"galina-satchanska",fullName:"Galina Satchanska"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6670",title:"Secondary Metabolites",subtitle:"Sources and Applications",isOpenForSubmission:!1,hash:"05d354e4a05e7df7d08ea65f76e0b268",slug:"secondary-metabolites-sources-and-applications",bookSignature:"Ramasamy Vijayakumar and Suresh S.S. 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Soil is the Earth’s fragile skin that anchors all life comprising countless species that create a dynamic and complex ecosystem. Soil is a major component of the environmental system. It is a major resource of the earth with a lot of potentials. Generally, soil has been described as the basis of human civilisation. This is because soil supports plants, which provide nutrition for man and his livestock [1]. The ability of the soil to continue providing essential services in the face of disturbance, whether natural or human induced, is essential to maintain or improve crop production overtime. Crop production is a function of the soil, management and the environment (of which water availability and quality are important indices). The quality of tropical soils, water quality and the synergy between them is highly imperative for optimum crop production. The availability of both water and plant nutrients is largely controlled by the physico-chemical properties, micro-environment of soils, the success and failure of any species of a particular area are, therefore, governed by the quality of soil characteristics [2].
\nSoil quality is the ability of a soil to perform functions that are essential to people and the environment [3]. It is the capacity of soil to perform specific functions of interest to human [4]. Soil quality has hitherto been equated with agricultural productivity. Soil conservation practices geared to maintain soil productivity are as old as agriculture itself. Soil quality is implied in many decisions farmers make about land purchases and management, and in the economic value rural assessors place on agricultural land for purposes of taxation. The concern of soil quality has challenged human kind for over 10,000 years; the definition and the basic concept remain a work in progress and keep evolving with every generation [3].
\nSimilarly, the importance of water in any crop production cannot be overemphasised. Cassava requires a certain amount of water daily to meet its crop water requirements [5]. Water is regarded as an intrinsic factor in any crop production as their function in food production, nutrient mineralisation and distribution, as well as plant turgidity in every crop production cannot be extremely emphasised. Water is a major constituent of living plant tissues, which consist of about 90% water. Water is involved in most of the physical, chemical and biological processes that occur in soils. In addition, all biological processes within the living plants depend on water. The optimal moisture conditions for any crop vary depending on many factors, such as soil type, climate conditions, growth rate and habit [5]. The favourable soil moisture tension should be maintained throughout the entire growth period of plants due to the relationship between evapotranspiration and biomass production.
\nCassava (Manihot esculenta Crantz) has been identified as one of the most important food crops in Africa. It derives its importance from the fact that it is starchy and thickened, with tuberous roots that serve as valuable sources of cheap calories, especially in developing countries with widespread calorie deficiency and malnutrition. In many parts of Africa, the leaves and tender shoots of cassava are also consumed as vegetables [6]. Over two-thirds of the total production of cassava is consumed in various forms by humans. The International Food Policy Research Institute (IFPRI) in 2014 noted that cassava is an insurance crop that increases food security because they can be left in the ground until needed [7]; and their usage as a source of ethanol for fuel, energy in animal feed and starch for industry is increasing. The crop is amenable to agronomic as well as genetic improvement juxtaposed with a high yield potential under good conditions and performs better than other crops under suboptimal conditions. It is grown widely in several countries in sub-Saharan Africa and Madagascar. Cassava was introduced into Africa in the latter half of the sixteenth century from South America and, perhaps, also from Central America, where it is believed to have originated. Globally, there has been widespread production of cassava across continents. Thailand, Vietnam, Indonesia and Costa Rica have been reported as the world leading exporters of cassava [8].
\nAlthough Nigeria is the world’s largest producer of cassava (Figure 1), however, its exports have been progressively reduced by the brunt population increase in the nation, implying that production is not enough to feed the current population in the country. The African Development Bank (AfDB) reported in 2015 that although Nigeria produces 20% of the world’s cassava, the country exports less than 1% of its produce. It was concluded that cassava production in the tropical Nigeria needs to increase with the rising population and this has been significantly influenced by the changing climate and the poor soil quality conditions arising due to soil degradation [8]. This invariably laid credence to the pertinence of galvanising strategies for boosting cassava production and export in the tropical Africa. This review will however consider soil quality, water characteristics and their synergy for suitable and optimum production of cassava in tropical soils.
\nWorld cassava production in 2011 (source:
The demand on soil resources in increasing, especially for new and conflicting soil functions like enhancing food security, improving water quality, disposing urban and industrial wastes and mitigating climate change. Thus, soil quality and its management are more important now than ever before, especially in developing countries that are characterised by high risks of soil degradation, predominantly resource—poor and small landholders [4].
\nSoil quality is the capacity of soil to perform specific functions of interest to human. Soil quality has historically been equated with agricultural productivity. Soil conservation practices to maintain soil productivity are as old as agriculture itself. Soil quality is implied in many decisions farmers make about land purchases and management and in the economic value rural assessors place on agricultural land for purposes of taxation. The concern of soil quality has challenged human kind for at least 10,000 years; the definition and the basic concept remain a work in progress and keep evolving with every generation.
\nFurthermore, soil quality is defined as the ability of a soil to perform functions that are essential to people and the environment [9]. Soil quality is not limited to agricultural soils. The first step in science of agriculture is the recognition of soils and of how to distinguish that which is of good quality and that which is of inferior quality. However, in spite of numerous definitions of soil quality, reviewed reports suggest that the widely accepted definition of the concept of soil quality was laid down by the Soil Science Society of America (SSSA) in 1996 which states that soil quality is the capacity of a specific kind of soil to function within natural or managed ecosystem boundaries, sustain plant and animal productivity, maintain or enhance water and air quality and support human health and habitation.
\nSoil functions keep changing with time and are different with developing compared with developed countries [4]. Although the definition of soil quality may be universal, the fact that its application is soil/society specific needs to be recognised for the concept to be useful in addressing the problems of resource-poor farmers in developing countries of the tropics. Larson and Pierce [10] defined soil quality as the capacity of a soil to function within the ecosystem boundaries and interact positively with the environment external to that ecosystem. Three soil functions are considered essential: provide a medium for plant growth, regulate and partition water flow through the environment and serve as an effective environmental filter. However, no soil is likely to successfully provide all these functions, some of which occur in natural ecosystems and some of which are the result of human modification. Hence, soil quality depends on the extent to which soil functions to benefit humans.
\nThe qualities of tropical soils are imperative indices towards the sustainable production of cassava. Cassava is known to be a heavy feeder, and literatures have opined that more than average output is obtainable from cassava grown on marginal lands. However, in view of the ever-increasing population of the tropical Africa (most notably in Nigeria), and with the production rates seldom meeting the increasing market demands of the produce, production of cassava on quality soils is therefore an imperative factor which when juxtaposed with good management and adequate climatic conditions, the production of cassava can be improved.
\nMore so, speaking in an interview in 2016, the Provost of the Federal College of Agriculture, Akure (FECA), Dr. Samson Odedina, while demonstrating the profitability of cassava production enterprise to young people and emerging farmers noted that farmers obtain an average yield of 8–10 tonnes of cassava per hectare, adding that the yield is far below the potentials of the crop. He further stressed that if the soil conditions are well managed, farmers can get up to 50–60 tonnes per hectare if they follow the recommended soil management practices. This increasingly justifies the pertinence of the quality of soils used for cassava production in tropical Nigeria.
\nIn addition, the FAO in 2017 reported that cassava has the reputation of causing serious erosion when grown on sloppy soils [11]. Researchers have also argued that this reputation is undeserved, since cassava is often grown on already-eroded soils where few other crops can survive and be productive. Nevertheless, concise reviews of related literatures generally maintained that cassava production on slopes causes increased erosion on an annual basis than other crops grown under the same circumstances. Cassava, in conjunction with common bean (Phaseolus vulgaris), upland rice and cotton, tends to cause considerably more erosion than cereals (like maize), peanut, sugarcane, pineapple or sweet potato. This was predominantly attributed to the fact that cassava needs to be cultivated at a relatively wide spacing. The canopy formation and the initial growth phase are slow, leaving the soil exposed to the direct impact of rainfall during the first 3–4 months of the cropping season. Contrarily, once the crop canopy is closed, erosion is usually minimal during the remainder of the crop cycle (Figure 2).
\nNigeria’s cassava production in the world and Africa totals, 1961–2012 [
The soil condition used for the production of cassava in Nigeria is of utmost importance if the demands for the produce are to be met before the year 2030 (Figure 3). For good growth of cassava, the soil used for production must have adequate room for water and air movement and for root growth. Also, the rising pressure on agricultural lands has made it difficult to obtain high-quality lands for sustainable production of deep-rooted crops like cassava. The insurgence of climate change and its effects on tropical soils has also increased this malady. These, therefore, lay emphasis on the true need of establishing soil management techniques aimed at boosting soil physical, chemical and biological conditions—which are main indices for soil quality towards the optimum production of cassava in this high-demand region of West Africa. Hence, based on reviewed statistics, cassava production in Nigeria will increase greatly with optimum soil, environmental and management conditions.
\nCassava demand and supply projections in Nigeria [
Soil is likely to show great variability in their physical, chemical and biological properties because the soil is a heterogeneous unit. Knowledge of variability of soil properties is highly indispensable as this can affect crop yield. A study of the variability trends of soils is essential in order to highlight the soil potentials and enhance their management and productivity [14].
\nAnikwe et al. [15] noted that the spatial variability of soil properties has effects on crop production across an agricultural field. They emphasised that it is important to be aware of the effect of spatial variability of soil properties when choosing indicator variables of soil quality for crop production. Although when, how and where to collect soil samples for soil quality determination may differ according to the objective of the assessment being made, management history and current inputs should also be considered to ensure valid interpretation of the information.
\nSoil quality assessment for agricultural production is an important operation towards sustainable crop and livestock production in tropical Africa. Owing to the high degree of variability that is characteristic of tropical soils, there is a need for the assessment of soil condition and capability to offer suitable crop outputs. Fundamentally, soil productivity for cassava production is a function of soil quality and management. Soil quality assessment is the process of measuring the management-induced changes in soil as we attempt to get soil to do what we want it to do. The ultimate purpose of assessing soil quality is to provide the information necessary to protect and improve long-term agricultural productivity, water quality and habitats of all organisms including people [16].
\nBasically, Soil Science Society of America [3] reported that soil quality is an inherent attribute of a soil that is inferred from soil characteristics or indirect observations. Papendick et al. [17] suggested that a minimum data set (MDS) of soil characteristics representing soil quality must be selected and quantified. The MDS may include biological, physical or chemical soil characteristics otherwise known as soil quality indicators (Figure 4).
\nShowing key indicators of soil quality [
Furthermore, the US Department of Agriculture [19] defined soil quality indicators as physical, chemical or biological properties, processes and characteristics that can be measured to monitor changes in the soil. The types of indicators that are the most useful depend on the function of soil for which soil quality is being evaluated. Sojka and Upchurch [20] highlighted that while recognising some controversies about the basic concept of soil quality, considerable progress had been made in the 1990s in identifying the indicators of soil quality. However, indicators of soil quality can be generally categorised into four groups: visual, physical, chemical and biological quality indicators [19].
\nThis may be obtained from observation or photographic interpretation. Exposure of subsoil, change in colour, ephemeral gullies, ponding, run off, plant response, weed species, blowing soil and deposition are only a few examples of potential locally determined indicators. Visual evidence can be a clear indication that soil quality is threatened or changing [21]. Adeoye and Agboola [22] maintained that for sustainable cassava (or any other crop) production, the presence of spear grass on the field to be cultivated is a good indication of a soil with good fertility conditions. In addition, the presence of Chromolaena odorata suggests that the soil possesses good hydrological properties, which is a necessity for cassava production in the early 3–4 months of the growth period.
\nThese are related to the arrangement of solid particles and pores. The soil physical characteristics are necessary part of soil quality assessment for cassava production because they often cannot be easily improved [23] during the course of the cropping season. Lal [18] reported that important soil physical parameters to be assessed include soil aggregation, available water capacity, texture, saturated hydraulic conductivity, bulk density, infiltration rate and rooting depth. Researchers have further stressed the need for establishing a quantitative assessment of these soil physical parameters in order to predict biomass productivity, soil organic carbon dynamics, transport processes of water and solutes, etc.
\nAssessment of soil quality based on soil chemistry, whether the property is a contaminant or part of a healthy system requires a sampling protocol, a method of chemical analysis and an understanding of how its chemistry affects biological systems and interacts with mineral forms and standards for soil characterisation and suitability classification for cassava production in tropical soils. In light of these, Larson and Pierce [10] laid emphasis on those chemical properties that either inhibit the root growth or affect nutrient supply due to the quantity present or the availability. Also, Reganold and Palmer [24] suggested chemical parameters related to nutrient availability as measures of soil quality, including cation exchange capacity (CEC), total nitrogen and phosphorus, soil pH and extractable phosphorus, sulphur, exchangeable calcium, magnesium and potassium, while Karlen et al. [25] opined that total and available plant nutrients and nutrient cycling rates should be included in soil quality assessments for optimum crop productivity. Nevertheless, Abua [26] highlighted the importance of maintaining high levels of nitrogen and phosphorus in the soils as chemical indices for quality soils to be used for cassava production in southern Nigeria.
\nBasically, microorganisms and microbial communities are dynamic and diverse, making them sensitive to changes in soil conditions [27]. Their populations include fungi, bacteria including actinomycetes, protozoa and algae. However, some soil organisms such as nematodes and bacterial and fungal pathogens reduce plant productivity. Visser and Parkinson [28] reported that diverse soil microbiological criteria may be used to indicate deteriorating or improving soil quality, and measurement of one or more components of the nitrogen cycle including ammonification, nitrification and nitrogen fixation may be used to assess soil fertility and soil quality.
\nNevertheless, USDA [19] devised biological indicators of soil quality to include measurement of micro- and macro-organisms, their activity, or by-products; and also suggested measurement of decomposition rates of plant residue in bags or measurement of weed seed numbers, or pathogen population can also serve as biological indicators of soil quality.
\nWater is a major constituent of living plant tissues, which consist of about 90% water, and all biological processes within the living plants depend on it [5]. Water is regarded as the most important of the four soil physical factors that affect plant growth (mechanical impedance, water, aeration and temperature) [29]. The optimal moisture conditions for any crop vary depending on many factors such as soil type, climate conditions, growth rate and habit, etc. [30]. The water movement in soils for any given crop production (a case study of cassava) is defined by the soil water characteristic curve.
\nThe soil-water characteristic curve (SWCC) defines the relationship between (pore water suction) matric suctions (ψ) and water content [gravimetric (w) or volumetric (θ) or degree of saturation (S)] [31]. The soil-water characteristics (also known as the soil-water retention or desorption curve) can be described as a measure of the water holding capacity (i.e. storage capacity) of the soil as the water content changes when subjected to various values of suction. SWCC is an indication of the ability of the soil to release water for plants use. The soil-water characteristics are a conceptual and interpretative tool through which the behaviour of unsaturated soils can be understood. As the soil moves from the saturated state to drier states (unsaturated states), the distribution of the soil, water and air phases changes as the stress state changes. The relationships between these phases take on different forms and influence the engineering properties of unsaturated soils [32, 33, 34].
\nGenerally, the curve is a function of soil texture and soil structure. The graph of SWCC can be used to obtain the field capacity (FC) and the permanent wilting point (PWP). The curve also explains how different soil structures will hold and release water. From the SWCC curve (Figure 5), it can be deduced that a fine-textured soil (like peats) will hold more water at FC and PWP than a coarse-textured soil (sand). The relationship between pore water suction and water content, as presented in a SWCC, is one fundamental relationship used to describe unsaturated behaviour of a soil. Suction is inversely proportional to the water content in a soil. Suction generally increases as the soil desaturates. Increasing suction generally results in high resistance to flow and increase in effective stress. Desiccation is a by-product of the increased effective stress [36]. Increasing suction in compacted clays due to decrease in water content modifies the flow behaviour of covers. During desiccation, the saturation of a liner is reduced and the remaining pore water is held at increasingly large suction.
\nSoil moisture retention curve [
The relationship between saturation and suction during desiccation is described using the SWCCs. Knowledge of suction and corresponding water content in the soil can be used to predict cracking potentials of liners. The onset and resulting amount of cracking can be correlated to a soil-specific critical suction level [31]. Hence, the SWCC provides critical input to the design of a compacted clay cover liner due to its potential impact on flow rates and the desiccation process. More so, Hillel [37] reported that the shape of the SWCC is a function of the soil type. Soils with smaller pores have higher air entry pressure (ψa). Soils with wider ranges of pore sizes exhibit greater changes in matric suction with water content. The SWCCs of compacted clay soils depend on the compaction water content, compactive effort and plasticity index [31].
\nWater occurs in the soil pores in varying proportions. Some of the definitions related to the water held in the soil pores are as follows:
\nSoil-water movement [
The above definitions of the soil water are based on physical factors. Some properties of soil water are not directly related to the above significance to plant growth. These are discussed next.
\nFor a particular soil, certain soil-water proportions are defined which dictate whether the water is available or not for plant growth. These are called the soil-water constants. The soil-water constants refer to the different stages of moisture in the soil as one moves from a wet soil to a dry soil (i.e. from saturated to unsaturated soil condition). These constants are described below:
\nSoil holds water in two ways: (1) as a thin film on individual soil particles and (2) as water stored in the pores of the soil. Water stored as a thin film on individual soil particles is held in place by adsorption forces. Adsorption involves complex chemical and physical reactions, but in simple terms, a thin film of water adheres to the outside layers of soil particle molecules. Water stored in the pores of the soil is stored by capillary forces. An example of the capillary force phenomenon would be to place one end of a glass capillary tube in a pan of water. Water in the tube will rise to a certain height, which depends on the diameter of the capillary tube. This phenomenon can act in any direction and is the key to water being stored in soil pores.
\nThe soil-water tension simply refers to the amount of water retained [38]. The availability of soil moisture is now frequently described in terms of soil moisture tension, which is dependent upon surface forces, and in terms of total soil moisture stress, which includes surface and other forces arising from the presence of solutes in the soil solution. Soil-water tension (also known as soil-water potential) determines the ease by which water can be extracted from the soil. These are equivalent values, except for the sign (negative vs. positive), which might be thought of as either a push or a pull on the water. Water being held in pores by the capillary storage is held in the soil at a certain tension. The same is true for water held with the adsorption phenomenon.
\nAs the soil dries, these tensions become larger. It is easier for a plant to extract water being held at lower tensions. Plants develop the tension, or potential, to move water from the soil into the roots and distribute the water through the plant by adjusting the water potential, or tension, within their plant cells. For water to move from soil, into roots, into stems, into leaves and finally into air, the water potential must always be decreasing.
\nUnder waterlogged condition, the soil matric potential is zero (ψ = 0). This waterlogged condition is not favourable for cassava production. This is due to the inability of the crop to absorb nutrients from the soil as a result of poor respiration which tends to limit the crop energy potentials. Also the cassava plant cannot carry out other physiological processes like photosynthesis. At saturation, the soil-water tension is approximately 0.001 bars; it would therefore be easy for a cassava plant to extract water from a saturated soil [40]. Also, the dividing point between the available soil-water content and readily available soil-water content is named the
The water requirements of cassava at each developmental stage known as the
Soil–plant-water relations refer to the physical properties of soil and plants that affect the movement, retention and use of water. These relations must be considered in designing an operation system. Soil is a store house of plant nutrients, a habitat for bacteria, an anchorage for plant and a reservoir that holds the water needed for plant growth. The amount of water a soil can hold in available form for plant use is determined by its physical properties. This amount determines the length of time a plant can survive without water being added. It determines both the frequency of irrigation and the capacity of irrigation system needed to ensure continuous crop growth. Soil is a three-phase system comprising the solid phase (made of mineral and organic matter and various chemical compounds), the liquid phase (called soil moisture) and the gaseous phase (called the soil air). They also contain variety of living an organisms.
\nPlant growth depends on two important natural resources—soil and water [38, 40]. The soil provides the mechanical support and nutrient reservoir necessary for plant growth. Water is essential for plant life processes. Soil acts like a reservoir that holds water and nutrients that plants need to grow. Some soils are large reservoirs with more holding capacity that releases water and nutrients easily to plants, while other soils have limited reservoirs (Figure 5). Effective management of these resources for cassava production in Nigeria necessitates a detailed understanding of the synergy between soils, water and plants by the crop producer. Knowledge of the soil physical and hydrological properties can influence the decision-making process, such as determining what crops to plant and when to irrigate. Cassava (like most other arable crops) has varying water needs at different stages of growth. While the plant is young, it requires less water than when it is in the reproductive stage. As a plant approaches maturity, its water needs drops.
\nTwo important physical properties of soil, which differ the supply of water and air in soil, are texture and structure. Soil texture refers to the relative proportion of sand, silt and clay in a given volume of soil. The texture of the soil delineates the degree of fineness or coarseness of a soil as determined by the percentage of sand, silt and clay contained in the soil. The arrangement of these soil separates (sand, silt and clay) determines the size of pores in the soil. This lays credence to the reason why clay soil will hold more water than sandy soil in the same period. Soil structure on the other hand refers to the arrangement of soil separates into units called aggregates (which contain solids and pore spaces).
\nThe arrangements of the soil separates into aggregates (known as soil structure) will determine the proportion of the macropores (large pores, non-capillary pores and/or air pores) and micropores (small pores, capillary pores and/or water pores) in the soil. Sandy soils with larger soil particle sizes will tend to have more preponderance of large or macropores due to the coarseness of the soil. This limits the amount of water it can hold. Conversely, clay soils that are characterised by high proportion of micropores which serve as pathways for water movements will tend to hold more water at the same period (Figure 5). Nevertheless, in tropical regions of sub-Saharan Africa, where the soils are highly heterogenous, the prevailing soil and environmental conditions will determine the amount of water available for cassava or any crop production. Cassava as a root crop requires a substantial amount of moisture in the first 3–4 months of its growth; hence, soils with high water holding capacity culminating in high water table for the root absorption are highly essential for optimum production. However, waterlogged conditions must be avoided.
\nNigeria is a nation comprising various vegetation zones that differ in their soil and climatic characteristics. Cultivation of cassava in these diverse agro-ecologies has yielded varying quantities of cassava in different geopolitical zones in nation. The FAO statistics [8] noted that on a per capita basis, North-Central was the highest producing state at 0.72 tonnes per person, followed by South-East (0.56), South–South (0.47), South-West (0.34), North-West (0.10) and North-East (0.01).
\nAlso, earlier reports from the International Institute of Tropical Agriculture in 2004 noted Cross River in the South–South geo-political zone as well as Benue and Kogi state in the North-Central zone were the largest producers of cassava in Nigeria (Figure 7). The study attributed the results to the management techniques and prevailing soil and climatic conditions. Cassava yields favourably in acidic soils with high organic matter content. Hillel [43] maintained that soils with high organic matter content tend to hold more water with good aeration and contain more nutrients and beneficial microbial population, culminating in a good soil structure. This entails that such soils which are predominantly medium-textured soils are of high quality and presents the best inherent soil physical condition for cassava production in view meeting the food demands of the rising population in Nigeria. Hence, to combat the rising issues of food security in sub-Saharan Africa (particularly in Nigeria), the use of soils with good quality and water characteristics, juxtaposed with adequate soil management, are essential in obtaining sustainable cassava production (Figure 8) in this region of the world in light of the increasing scores of persons and animal population.
\nCrop production by Nigerian states [
Harvested cassava roots in sub-Sahara Africa [
Soil-plant-water relation entails the physical properties of soil and plants that affect the movement, retention and use of water. Two important physical properties of soil, which influence the supply of water and air in soil for crop production, are soil texture and soil structure. Increasing cassava production outputs is extremely important in the face of a growing global population, but equally essential is ensuring that the correct quantity and quality are produced and distributed and in an environmentally sustainable manner with improved soil and water conditions. Cassava production in the wake of the brunt population increase in tropical regions of sub-Saharan Africa like Nigeria has been greatly affected by poor soil and water quality, which are intrinsic properties for sustainable optimum crop production. The varying effects of soil and water quality as well as the synergy of soil-water and crop play an important role in the lifecycle of cassava and ensure optimum production on a sustained basis. This chapter reviewed and discussed soil quality and its assessment methods, soil-water characteristics and the relationship between the soil, water and crop for soil quality management and the sustainable optimum production of cassava in tropical Nigeria.
\nDue to industrial uses, researchers have developed a strong interest in boundary-layer flow and heat transmission in thin liquid films on stretching surfaces. Understanding heat transfer inside a thin liquid film is critical in engineering for operations, such as wire and fiber coating, food processing, cooling metallic plates, reactor fluidization, drawing polymer sheets, and aerodynamic extrusion of plastic sheets. This knowledge is critical during the extrusion process to ensure the extrudate’s surface quality remains consistent. By minimizing friction, transparency, and strength, a smooth surface enhances the aesthetic and performance of the product [1]. The flow and heat transfer of laminar thin films across an unstable stretched sheet with a changing transverse magnetic field is investigated. The graph shows how various parameters affect the temperature distribution. Listed below are some of the key findings from our graphic research. Sakiadas’ research began with an investigation of MHD flow’s boundary-layer behavior on a stretching surface [2]. Wang [3] made significant contributions to the study of thin-film flow across a stretched sheet. Additionally, Andersson et al. [4, 5] improved Wang’s work by including a power-law fluid with changeable physical characteristics. Wang and Pop [6] later devised a homotopy analytic approach for analyzing the heat transfer features of a power-law fluid’s liquid film flow.
Khan et al. [7] showed that when the thin film parameter is increased, the temperature profiles get lower and the concentration profiles get higher. They did this while also looking at the thermal conductivity and viscosity of fluids moving through a stretching sheet. Pop et al. [8] used computational methods to explore the effect of injection and suction on the flow of a continuous laminar gravity-driven film down a vertical wall, emphasizing the importance of mass transfer and the Prandtl number. According to Khan et al. [9], a second-grade fluid flowing through a porous medium through a stretched sheet exhibits thin-film flow and heat transfer.
Sun et al. [10] investigated the thin-film flow over a rotating disc subjected to heat source and nonlinear radiation and found that increase in the rotation parameter result in a decrease in the azimuthal component of velocity, whereas increase in the temperature function of the radiation parameter. Ma et al. [11] studied how liquids flow and evaporate in a rocket combustion chamber with high temperatures and high shear forces. He investigated the flow and evaporation of a liquid film in a rocket combustion chamber with high temperatures and high shear forces. Khan et al. [12] explored Darcy–Forchheimer laminar thin-film flow with MHD and the investigation of heat transfer on an unstable horizontal stretched surface. Thermal radiation and viscous dissipation effects on thin-film flow are also examined. Using boundary-layer flow, you can look at a source of heat that emits thermal radiation. This could be very useful in industrial engineering operations like electric power generation and solar energy modernization and in astrophysical flow. Shahzad et al. [13] explored thin-film flow for radially expanding surfaces using magnetic effects and viscous dissipation for the first time. They analyzed that as the magnetic and unsteadiness parameters are raised, the film thickness decreases.
To the best of the author’s knowledge, the provided facts on thermal analysis have not been investigated previously for the radially stretching surface by taking in account the effects of Joule heating and radiation effects. Section 2 detailed the governing coupled PDEs, which were later changed into coupled nonlinear ODEs by suitable transformations; Section 3 explained the approach used to solve the problem; Section 4 summarised the findings and discussed them, while Section 5 expanded on the final remarks.
If an incompressible fluid flows through a flat plate with a uniform temperature
Schematic diagram of fluid flow.
We obtain
So Eq. (3) can be rewritten as
where
An acceptable stream function
where
where
The rate of heat transfer is represented by the quantity of physical interest
The system of nonlinear PDEs is given in Eqs. (2) and (4) subject to given boundary conditions given by Eq. (5) are transformed to ODEs via similarity transformation and solved via the shooting method. The following are the third-order differential equations for the second-order nonlinear ODE and the second-order nonlinear ordinary differential for first order.
The iterative procedure will end with the appropriate level of precision.
This work fundamentally alters our understanding of thin films. Unsteadiness, magnetic parameters, Eckert number, Prandtl number, and radiation parameters are the regulating parameters. Numerical simulation is utilized in conjunction with analytical solutions of nonlinear differential equations. Additionally, dimensionless parameters were investigated in axisymmetric MHD thin liquid film only for heat transfer past the stretching surface.
According to Figure 2, a higher unsteadiness parameter (S) results in a decrease in temperature, which in turn enhances heat transmission in thin liquid films.
Illustration of
The temperature distribution for various Eckert numbers is depicted in Figure 3. This physical characteristic characterizes the relationship between kinetic and internal energy.
Illustration of
The Prandtl number presents the relationship between momentum and thermal diffusivity. When the Prandtl number is decreased, the thickness of the boundary- layer drops, further restricting heat transfer. The Prandtl number is plotted against the temperature distribution in Figure 4. The thermal boundary layer was decreased as a result of the enhanced dissipation.
Illustration of
The influence of the radiation parameter
Illustration of
For a fixed unsteadiness parameter S, the temperature distribution is shown in Figure 6 in relation to the magnetic field value M. As M rises, so does the thickness of the thermal boundary layer. As a result of the Lorentz force, the thermal boundary layer becomes thicker because frictional drag increases. In turn, this causes an increase in the thermal boundary-layer thickness. The purpose of Table 1 is to examine the influence of several important factors on the dimensionless heat transfer rate at the surface. The Prandtl number and the unsteadiness parameter have an effect on the rate of heat transfer at the surface.
Illustration of M on
[13] | Present | ||||
---|---|---|---|---|---|
Effect of pertinent parameters on heat transfer rate.
The flow and heat transfer through a stretching sheet with a variable transverse magnetic field is studied in this work. The shooting strategy is used to solve the governing equations numerically. The temperature distribution is shown in the graph below as a function of several parameters. In summary, the following are some of the most significant discoveries from our graphical investigation:
Enhance the thermal boundary layer, decrease fluid particle movement, and increase the temperature field when a magnetic field is applied to an electrically conducting fluid.
The temperature decreases for the increasing values of Prandtl and Eckert numbers, i.e., both have the same effect.
The influence of radiation parameter Rd. rises in thermal boundary- layer thickness, which enhances heat transmission.
polar coordinate
thermal diffusivity
velocity component
applied magnetic field
fluid’s Temperature
reference temperature
specific heat
pressure
Stokes stream function
Partial differential equations
electrical conductivity
density of fluid
Local Reynolds number
Local skin-friction coefficient
Nusselt number
Prandtl number
Eckert-number
thickness of the film
kinematic viscosity
Ordinary differential equations
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Almost all the parts of this plant, that are, fruit, leaves, flower bud, trunk, and pseudo-stem, can be utilized. This chapter deals with the fiber extracted from the pseudo-stem of the banana plant. It discusses the production of banana pseudo-stem fiber, which includes plantation and harvesting; extraction of banana pseudo-stem fiber; retting; and degumming of the fiber. It also deals with the characteristics of the banana pseudo-stem fiber, such as morphological, physical and mechanical, durability, degradability, thermal, chemical, and antibacterial properties. Several potential applications of this fiber are also mentioned, such as the use of this fiber to fabricate rope, place mats, paper cardboard, string thread, tea bags, high-quality textile materials, absorbent, polymer/fiber composites, etc.",book:{id:"7544",slug:"banana-nutrition-function-and-processing-kinetics",title:"Banana Nutrition",fullTitle:"Banana Nutrition - Function and Processing Kinetics"},signatures:"Asmanto Subagyo and Achmad Chafidz",authors:[{id:"257742",title:"M.Sc.",name:"Achmad",middleName:null,surname:"Chafidz",slug:"achmad-chafidz",fullName:"Achmad Chafidz"},{id:"268400",title:"Mr.",name:"Asmanto",middleName:null,surname:"Subagyo",slug:"asmanto-subagyo",fullName:"Asmanto Subagyo"}]},{id:"69568",title:"Water Quality Parameters",slug:"water-quality-parameters",totalDownloads:10165,totalCrossrefCites:14,totalDimensionsCites:36,abstract:"Since the industrial revolution in the late eighteenth century, the world has discovered new sources of pollution nearly every day. So, air and water can potentially become polluted everywhere. Little is known about changes in pollution rates. The increase in water-related diseases provides a real assessment of the degree of pollution in the environment. This chapter summarizes water quality parameters from an ecological perspective not only for humans but also for other living things. According to its quality, water can be classified into four types. Those four water quality types are discussed through an extensive review of their important common attributes including physical, chemical, and biological parameters. These water quality parameters are reviewed in terms of definition, sources, impacts, effects, and measuring methods.",book:{id:"7718",slug:"water-quality-science-assessments-and-policy",title:"Water Quality",fullTitle:"Water Quality - Science, Assessments and Policy"},signatures:"Nayla Hassan Omer",authors:null},{id:"40180",title:"Plant Tissue Culture: Current Status and Opportunities",slug:"plant-tissue-culture-current-status-and-opportunities",totalDownloads:66561,totalCrossrefCites:45,totalDimensionsCites:96,abstract:null,book:{id:"3568",slug:"recent-advances-in-plant-in-vitro-culture",title:"Recent Advances in Plant in vitro Culture",fullTitle:"Recent Advances in Plant in vitro Culture"},signatures:"Altaf Hussain, Iqbal Ahmed Qarshi, Hummera Nazir and Ikram Ullah",authors:[{id:"147617",title:"Dr.",name:"Altaf",middleName:null,surname:"Hussain",slug:"altaf-hussain",fullName:"Altaf Hussain"}]},{id:"66996",title:"Ethiopian Common Medicinal Plants: Their Parts and Uses in Traditional Medicine - Ecology and Quality Control",slug:"ethiopian-common-medicinal-plants-their-parts-and-uses-in-traditional-medicine-ecology-and-quality-c",totalDownloads:4172,totalCrossrefCites:6,totalDimensionsCites:11,abstract:"The main purpose of this review is to document medicinal plants used for traditional treatments with their parts, use, ecology, and quality control. Accordingly, 80 medicinal plant species were reviewed; leaves and roots are the main parts of the plants used for preparation of traditional medicines. The local practitioners provided various traditional medications to their patients’ diseases such as stomachaches, asthma, dysentery, malaria, evil eyes, cancer, skin diseases, and headaches. The uses of medicinal plants for human and animal treatments are practiced from time immemorial. Stream/riverbanks, cultivated lands, disturbed sites, bushlands, forested areas and their margins, woodlands, grasslands, and home gardens are major habitats of medicinal plants. Generally, medicinal plants used for traditional medicine play a significant role in the healthcare of the majority of the people in Ethiopia. The major threats to medicinal plants are habitat destruction, urbanization, agricultural expansion, investment, road construction, and deforestation. Because of these, medicinal plants are being declined and lost with their habitats. Community- and research-based conservation mechanisms could be an appropriate approach for mitigating the problems pertinent to the loss of medicinal plants and their habitats and for documenting medicinal plants. Chromatography; electrophoretic, macroscopic, and microscopic techniques; and pharmaceutical practice are mainly used for quality control of herbal medicines.",book:{id:"8502",slug:"plant-science-structure-anatomy-and-physiology-in-plants-cultured-in-vivo-and-in-vitro",title:"Plant Science",fullTitle:"Plant Science - Structure, Anatomy and Physiology in Plants Cultured in Vivo and in Vitro"},signatures:"Admasu Moges and Yohannes Moges",authors:[{id:"249746",title:"Ph.D.",name:"Admasu",middleName:null,surname:"Moges",slug:"admasu-moges",fullName:"Admasu Moges"},{id:"297761",title:"MSc.",name:"Yohannes",middleName:null,surname:"Moges",slug:"yohannes-moges",fullName:"Yohannes Moges"}]},{id:"29764",title:"Underlying Causes of Paresthesia",slug:"underlying-causes-of-paresthesia",totalDownloads:193348,totalCrossrefCites:3,totalDimensionsCites:7,abstract:null,book:{id:"1069",slug:"paresthesia",title:"Paresthesia",fullTitle:"Paresthesia"},signatures:"Mahdi Sharif-Alhoseini, Vafa Rahimi-Movaghar and Alexander R. 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It’s a beautiful fruit with smooth, shining skin. Yellow, red, and purple fruits are available. This fruit contains vitamins, minerals, fiber, and antioxidants. It has a very low-calorie count. Breeding focuses on fruit quality through selection, hybridization, and biotechnological treatments for plantation and post-harvest management. Diseases, pests, viruses, and physiological abnormalities can be treated with plant protection techniques. Like other fruits, it’s edible after harvesting. Made into juices, concentrates, jams, gelatins, and sweets. If processing facilities and transport are available, it can be exported as pulp or concentrate. The tamarillo can diversify sub-tropical fruit production as a high-value cash crop, with excellent fruits commanding premium prices in Europe, North America, and Japan.",book:{id:"11311",title:"Tropical Plant Species",coverURL:"https://cdn.intechopen.com/books/images_new/11311.jpg"},signatures:"Rafiq Ahmad Shah, Parshant Bakshi, Hamidullah Itoo and Gaganpreet Kour"},{id:"82491",title:"Heterologous Expression of Genes in Plants for Abiotic Stresses",slug:"heterologous-expression-of-genes-in-plants-for-abiotic-stresses",totalDownloads:0,totalDimensionsCites:null,doi:"10.5772/intechopen.105171",abstract:"Abiotic stresses are considered to be the major factors causing a decrease in crop yield globally, these stresses include high and low temperature, salinity, drought, and light stress etc. To overcome the consistent food demand for the ever-growing population, various genes from micro-organisms and non-plant sources have been expressed in transgenic plants to improve their tolerance against abiotic stresses. Gene expression in transgenic plants through conventional methods are time-consuming and laborious that’s why advanced genetic engineering methods for example Agrobacterium-mediated transformation and biolistic methods are more accurate, useful, and less time-consuming. This review provides an insight into various bacterial genes for example mtID, codA, betA, ADH, IPT, DRNF1 and ggpPS, etc. that have been successfully expressed in transgenic plants against various abiotic stress for stress tolerance enhancement and crop yield improvement which exhibited good encouraging results. Genes from yeast (Saccharomyces cerevisiae) have been introduced in transgenic plants against drought and salinity stress. All these genes expressed from non-plant sources in plants can be very helpful to enhance crops for better yield productivity in the future to meet the demands of the consistently rising population of the world.",book:{id:"11330",title:"Plant Response Mechanisms to Abiotic Stresses",coverURL:"https://cdn.intechopen.com/books/images_new/11330.jpg"},signatures:"Shahzad Ali, Nadir Zaman, Waqar Ali, Majid Khan, Muhammad Aasim, Asmat Ali and Muhammad Usman"},{id:"83015",title:"Acute Changes in Lipoprotein-Associated Oxidative Stress",slug:"acute-changes-in-lipoprotein-associated-oxidative-stress",totalDownloads:0,totalDimensionsCites:null,doi:"10.5772/intechopen.106489",abstract:"As inflammatory and oxidative stress are associated with cardiometabolic diseases, detection of abnormal fasting levels of inflammatory and oxidative biomarkers are indicative disease presence and may be too late for any preventive management. Metabolic flexibility refers to the ability of various metabolic processes to compensate for these acute changes and return all metabolites to baseline levels. By monitoring responses of key biomarkers to a standardized physiologic challenge, it is possible to assess the ability of the body to restore homeostasis, that is a measure of metabolic flexibility. Acute changes in lipoprotein-associated biomarkers of oxidative stress have been demonstrated following meal consumption. These include changes in circulating levels of oxidized low-density lipoproteins (LDL), levels of autoantibodies to malondialdehyde-modified LDL, as well as the oxidative susceptibility of isolated plasma LDL. These responses depend on the type and amount of dietary fats in the meal. Management with certain lipid-lowering drugs could also be shown to affect these meal-induced changes. However, plasma levels may be underestimated as we can demonstrate a spike in lipoprotein-associated biomarkers of oxidative stress resulting from the release oxidatively modified epitopes from the arterial wall by an intravenous bolus of heparin.",book:{id:"11671",title:"Importance of Oxidative Stress and Antioxidant System in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/11671.jpg"},signatures:"Ngoc-Anh Le"},{id:"83041",title:"Responses of Endoplasmic Reticulum to Plant Stress",slug:"responses-of-endoplasmic-reticulum-to-plant-stress",totalDownloads:0,totalDimensionsCites:null,doi:"10.5772/intechopen.106590",abstract:"Global climate change has resulted in alterations in the biotic and abiotic conditions of the planet. This has led to changes in the agricultural system resulting from reduced water availability, increased temperature increase in the population and occurrences of pests and diseases. Plants are adversely affected when they experience any stress retarding their growth, development and productivity. Endoplasmic Reticulum (ER) is an organelle that shows a tremendous response when subjected to stress conditions. Therefore, to explore and comprehend plants’ multidimensional interactions when subjected to stress conditions, an insight into the molecular stress signalling in the ER in response to the stress situation is discussed in this chapter.",book:{id:"11674",title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg"},signatures:"Vishwa Jyoti Baruah, Bhaswati Sarmah, Manny Saluja and Elizabeth H. 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In this chapter, we present a short introduction to the concept of Eco-DRR and companion terms and propose a definition of FbS as a specific case of Nature-based Solutions for an ecosystem-based and integrated risk management of natural hazards. That is, we guide the reader through the maze of existing definitions and concepts and try to disentangle their meanings. Furthermore, we present an introduction to forest regulations in the Alpine Space and European protective forest management guidelines. 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Integrating transcriptome sequencing with other techniques such as chromatin immunoprecipitation, methylation, genome-wide association studies, manifests insights into genetic and epigenetic regulation. Epi-transcriptome including RNA methylation, modification, and alternative polyadenylation events can also be explored through long-read sequencing. In this chapter, we have presented an account of the basics of gene expression methods, transcriptome sequencing, and the various methodologies involved in the downstream analysis.",book:{id:"11349",title:"Gene Expression",coverURL:"https://cdn.intechopen.com/books/images_new/11349.jpg"},signatures:"Yogesh Shukla, Amol Phule, Harshvardhan Zala, Nakul D. Magar, Priya Shah, K. Harish, Tejas C. Bosamia, Kalyani M. 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He previously worked as a post-doctoral fellow at the Ben-Gurion University of Negev, Israel; University of the Free State, South Africa; and Central University of Technology Bloemfontein, South Africa. He obtained his Ph.D. in Organic Chemistry from Nagaoka University of Technology, Japan. He has published more than seventy-four journal articles and attended several national and international conferences as speaker and chair. Dr. Kendrekar has received many international awards. He has several funded projects, namely, anti-malaria drug development, MRSA, and SARS-CoV-2 activity of curcumin and its formulations. He has filed four patents in collaboration with the University of Central Lancashire and Mayo Clinic Infectious Diseases. His present research includes organic synthesis, drug discovery and development, biochemistry, nanoscience, and nanotechnology.",institutionString:"Visiting Scientist at Lipid Nanostructures Laboratory, Centre for Smart Materials, School of Natural Sciences, University of Central Lancashire",institution:null},{id:"428125",title:"Dr.",name:"Vinayak",middleName:null,surname:"Adimule",slug:"vinayak-adimule",fullName:"Vinayak Adimule",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/428125/images/system/428125.jpg",biography:"Dr. Vinayak Adimule, MSc, Ph.D., is a professor and dean of R&D, Angadi Institute of Technology and Management, India. He has 15 years of research experience as a senior research scientist and associate research scientist in R&D organizations. He has published more than fifty research articles as well as several book chapters. He has two Indian patents and two international patents to his credit. Dr. Adimule has attended, chaired, and presented papers at national and international conferences. He is a guest editor for Topics in Catalysis and other journals. He is also an editorial board member, life member, and associate member for many international societies and research institutions. His research interests include nanoelectronics, material chemistry, artificial intelligence, sensors and actuators, bio-nanomaterials, and medicinal chemistry.",institutionString:"Angadi Institute of Technology and Management",institution:null},{id:"284317",title:"Prof.",name:"Kantharaju",middleName:null,surname:"Kamanna",slug:"kantharaju-kamanna",fullName:"Kantharaju Kamanna",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284317/images/21050_n.jpg",biography:"Prof. K. Kantharaju has received Bachelor of science (PCM), master of science (Organic Chemistry) and Doctor of Philosophy in Chemistry from Bangalore University. He worked as a Executive Research & Development @ Cadila Pharmaceuticals Ltd, Ahmedabad. He received DBT-postdoc fellow @ Molecular Biophysics Unit, Indian Institute of Science, Bangalore under the supervision of Prof. P. Balaram, later he moved to NIH-postdoc researcher at Drexel University College of Medicine, Philadelphia, USA, after his return from postdoc joined NITK-Surthakal as a Adhoc faculty at department of chemistry. Since from August 2013 working as a Associate Professor, and in 2016 promoted to Profeesor in the School of Basic Sciences: Department of Chemistry and having 20 years of teaching and research experiences.",institutionString:null,institution:{name:"Rani Channamma University, Belagavi",country:{name:"India"}}},{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",biography:"Prof. Dr. Yusuf Tutar conducts his research at the Hamidiye Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Biochemistry, University of Health Sciences, Turkey. He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"436430",title:"Associate Prof.",name:"Mesut",middleName:null,surname:"Işık",slug:"mesut-isik",fullName:"Mesut Işık",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/436430/images/19686_n.jpg",biography:null,institutionString:null,institution:{name:"Bilecik University",country:{name:"Turkey"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a scientist and Principal Investigator at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering the lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via artificial intelligence-based analyses of exosomal Raman signatures. Dr. Paul also works on spatial multiplex immunofluorescence-based tissue mapping to understand the immune repertoire in lung cancer. Dr. Paul has published in more than sixty-five peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award and the 2022 AAISCR-R Vijayalaxmi Award for Innovative Cancer Research. He is a senior member of the Institute of Electrical and Electronics Engineers (IEEE) and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null}]}},subseries:{item:{id:"38",type:"subseries",title:"Pollution",keywords:"Human Activity, Pollutants, Reduced Risks, Population Growth, Waste Disposal, Remediation, Clean Environment",scope:"
\r\n\tPollution is caused by a wide variety of human activities and occurs in diverse forms, for example biological, chemical, et cetera. In recent years, significant efforts have been made to ensure that the environment is clean, that rigorous rules are implemented, and old laws are updated to reduce the risks towards humans and ecosystems. However, rapid industrialization and the need for more cultivable sources or habitable lands, for an increasing population, as well as fewer alternatives for waste disposal, make the pollution control tasks more challenging. Therefore, this topic will focus on assessing and managing environmental pollution. It will cover various subjects, including risk assessment due to the pollution of ecosystems, transport and fate of pollutants, restoration or remediation of polluted matrices, and efforts towards sustainable solutions to minimize environmental pollution.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/38.jpg",hasOnlineFirst:!1,hasPublishedBooks:!0,annualVolume:11966,editor:{id:"110740",title:"Dr.",name:"Ismail M.M.",middleName:null,surname:"Rahman",slug:"ismail-m.m.-rahman",fullName:"Ismail M.M. Rahman",profilePictureURL:"https://mts.intechopen.com/storage/users/110740/images/2319_n.jpg",biography:"Ismail Md. Mofizur Rahman (Ismail M. M. Rahman) assumed his current responsibilities as an Associate Professor at the Institute of Environmental Radioactivity, Fukushima University, Japan, in Oct 2015. He also has an honorary appointment to serve as a Collaborative Professor at Kanazawa University, Japan, from Mar 2015 to the present. \nFormerly, Dr. Rahman was a faculty member of the University of Chittagong, Bangladesh, affiliated with the Department of Chemistry (Oct 2002 to Mar 2012) and the Department of Applied Chemistry and Chemical Engineering (Mar 2012 to Sep 2015). Dr. Rahman was also adjunctly attached with Kanazawa University, Japan (Visiting Research Professor, Dec 2014 to Mar 2015; JSPS Postdoctoral Research Fellow, Apr 2012 to Mar 2014), and Tokyo Institute of Technology, Japan (TokyoTech-UNESCO Research Fellow, Oct 2004–Sep 2005). \nHe received his Ph.D. degree in Environmental Analytical Chemistry from Kanazawa University, Japan (2011). He also achieved a Diploma in Environment from the Tokyo Institute of Technology, Japan (2005). Besides, he has an M.Sc. degree in Applied Chemistry and a B.Sc. degree in Chemistry, all from the University of Chittagong, Bangladesh. \nDr. Rahman’s research interest includes the study of the fate and behavior of environmental pollutants in the biosphere; design of low energy and low burden environmental improvement (remediation) technology; implementation of sustainable waste management practices for treatment, handling, reuse, and ultimate residual disposition of solid wastes; nature and type of interactions in organic liquid mixtures for process engineering design applications.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorTwo:{id:"201020",title:"Dr.",name:"Zinnat Ara",middleName:null,surname:"Begum",slug:"zinnat-ara-begum",fullName:"Zinnat Ara Begum",profilePictureURL:"https://mts.intechopen.com/storage/users/201020/images/system/201020.jpeg",biography:"Zinnat A. Begum received her Ph.D. in Environmental Analytical Chemistry from Kanazawa University in 2012. She achieved her Master of Science (M.Sc.) degree with a major in Applied Chemistry and a Bachelor of Science (B.Sc.) in Chemistry, all from the University of Chittagong, Bangladesh. Her work affiliations include Fukushima University, Japan (Visiting Research Fellow, Institute of Environmental Radioactivity: Mar 2016 to present), Southern University Bangladesh (Assistant Professor, Department of Civil Engineering: Jan 2015 to present), and Kanazawa University, Japan (Postdoctoral Fellow, Institute of Science and Engineering: Oct 2012 to Mar 2014; Research fellow, Venture Business Laboratory, Advanced Science and Social Co-Creation Promotion Organization: Apr 2018 to Mar 2021). The research focus of Dr. Zinnat includes the effect of the relative stability of metal-chelator complexes in the environmental remediation process designs and the development of eco-friendly soil washing techniques using biodegradable chelators.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorThree:null,series:{id:"25",title:"Environmental Sciences",doi:"10.5772/intechopen.100362",issn:"2754-6713"},editorialBoard:[{id:"252368",title:"Dr.",name:"Meng-Chuan",middleName:null,surname:"Ong",slug:"meng-chuan-ong",fullName:"Meng-Chuan Ong",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRVotQAG/Profile_Picture_2022-05-20T12:04:28.jpg",institutionString:null,institution:{name:"Universiti Malaysia Terengganu",institutionURL:null,country:{name:"Malaysia"}}},{id:"63465",title:"Prof.",name:"Mohamed Nageeb",middleName:null,surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed",profilePictureURL:"https://mts.intechopen.com/storage/users/63465/images/system/63465.gif",institutionString:null,institution:{name:"Aswan University",institutionURL:null,country:{name:"Egypt"}}},{id:"187907",title:"Dr.",name:"Olga",middleName:null,surname:"Anne",slug:"olga-anne",fullName:"Olga Anne",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBE5QAO/Profile_Picture_2022-04-07T09:42:13.png",institutionString:null,institution:{name:"Klaipeda State University of Applied Sciences",institutionURL:null,country:{name:"Lithuania"}}}]},onlineFirstChapters:{paginationCount:6,paginationItems:[{id:"83073",title:"Dental and Orofacial Trauma Impacts on Oral-Health-Related—Quality of Life in Children: Low- and Middle-Income Countries",doi:"10.5772/intechopen.105845",signatures:"Yolanda Malele-Kolisa, Nazia Khan, Mpho P. 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