Descriptive statistics of variables used in the growth model.
\r\n\tThis book chapter’s main theme will be focused on transmission dynamics, pathogenesis, mechanisms of host interaction and response, epigenetics and markers, molecular diagnosis, RNA interacting proteins, RNA binding proteins, advanced development of tools for diagnosis, possible development of concepts for vaccines and anti drugs for RNA viruses, immunological mechanisms, treatment, prevention and control.
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In the past, economists focused themselves on identifying factors that have been determining women’s participation to labor market [1, 2, 3]. Nowadays, robust responses have been provided to this question. It has been shown that women are less represented among owners of big formal enterprises [4, 5]. Most of them are owners of small and medium-sized enterprises (SME) especially in developing countries (PED) [6]. If presently, the debate on the determinants of women’s participation to entrepreneurship seems to be ended, questions on their SMEs’ productivity, dynamism, and survival are still topical.
Theoretically, the question of efficiency of enterprises run by women should not be subjected to great debates. Etymologically, economy is defined as the art of managing well a home, that is to say more precisely the ability to have a more efficient internal organization. Now, it is known that a woman is the right person to manage a home. For example, in Burkina Faso, there is a common saying that goes as: “ Paglayiri,” meaning “ there shall never be a home without a woman.” This implies that if the economist’s first objective is to avoid wastes, everyone who agrees with this economy’s definition says likewise that, a woman would be more efficient than a man in managing economic affairs.
Women have not yet got the opportunity to show their economic know-how because they have long been discriminated on the labor market [2, 7]. Even if now, this discrimination is no more too obvious, there are still certain types of employments that they cannot afford to fill [8]. The importance of female entrepreneurship would then lie in its capacity to reduce discriminations against women on the labor market. Welter et al. [9] show that economic sectors whereby women are owners of private enterprises are sectors hiring more women. However, women’s capacity to create and manage dynamic jobs supplying SMEs for their counterparts is often limited by cultural and religious factors [10]. This implies that it will be erroneous to draw conclusions of a woman’s performances in entrepreneurship without considering institutional factors’ influences. In developing countries, informal institutions prevent women to fully and freely take part in the private and individual process of wealth accumulation [11]. These informal regulations or laws contribute to highlight discrimination against women in wages rate setting and on labor market in general [12, 13]. According to Pressman [14], these same informal institutions keep households run by women in poverty.
Therefore, even if women are predisposed to be more efficient than men in the economic arena, formal or informal institutional norms that have kept women out of the labor market for a long time could in the end damage their economic efficiency. For example, obligation for women to always stay at home to care for children (in some developing countries) would contribute to reduce their motivations to commit themselves to female entrepreneurship [10, 15, 16]. Udry [17] notes that in households run by men, about 6% of the output of the plot of land farmed by women is lost due to a bad distribution of production inputs in their disfavor.
Setting up a business in developing countries has always been difficult. The difficulty in undertaking stems mainly from the market’s failure. Access to credit seemed to be the biggest of these constraints. When we look particularly into this difficulty, we realize that women are the most constrained [18, 19, 20]. It would then be plausible to justify the weak performances experienced by enterprises run by women through their inability to acquire more physical capital due to credit access’ constraints. Fafchamps et al. [21] show that even if credit access’ constraints limit women’s capacity to increase their investment in physical capital, this does not explain why they are less efficient than those run by men. Other case studies, having been carried out by De Mel et al. [22] in Sri Lanka, Banerjee and Sendhil [15] in India and Karlan and Zinman [23] in the Philippines have also proven that the difference in terms of equipment would not explain alone the difference of productivity observed between women’s and men’s enterprises.
Lonstreth et al. [24] as well as Brush [25] think that women’s enterprises are less profitable than men’s because the concern of maximizing profit does not appear in their objective function. They create small informal production units just to busy themselves or to have a little financial and economic freedom. As for Minguez-Vera and Martin [26], they justify women’s enterprises’ weak performances by the fact that women take less risk than men when they are enterprises managers. Broadly speaking, Amin [27] points out that labor productivity and the size of women’s informal enterprises are by far inferior to those run by men. The output per capita of worker in women’s enterprises represents only 76% to the one of men’s enterprises. Concerning the size, the author thinks that men’s enterprises are 61% bigger than women’s enterprises. It even seems that these results can be generalized in the case of formal enterprises. Brush et al. [28] show that women’s formal enterprises generate an average income representing only 26% of men’s enterprises income. Through a study on 26 transition-state countries’ data, Sabarwal and Terrell [29] reach the result stating that women’s enterprises are less profitable than men’s enterprises.
Even if everything leads to believe that men are more efficient than women in businesses, some reports invite us to relativize these results. First, a woman works less for example in an enterprise and more in housework. In certain parts of the world, institutional constraints hinder them from being more educated compared to men. Second, when we study women’s enterprises’ productivity compared to men’s, it needs to be carried out by using data collected in the same field of activity. Chirwa [8] and Masters and Meier [30] assess that in developing countries, women practice less profitable and less risky economic activities. In any case, we must know that the above constraints will not and cannot justify by themselves the productivity differences observed between women and men in entrepreneurship. According to Amin [27], these factors do not explain more than 30% of the productivity difference observed between them.
Other justifying elements of this productivity difference have also been highlighted. For example, men’s enterprises are often family firms bequeathed by parents. As women rarely benefit from inheritance in certain regions of the world, this would explain why their enterprises are less experienced than men’s enterprises. Other authors explain women’s coming to business not to make profit but for other reasons which vary rapidly from a country to another. Women from poor households engage themselves in economic activities to support their husbands in family expenditure [31, 32]. The fact that some women reach a higher level of education motivates them into practicing entrepreneurship [33, 34]. The deplorable thing is the fact that these latter practice mostly in informal economic activities [35, 39]. For example, in developing countries, average 60% of working women hold an informal job. In Sub-Saharan Africa, 84% of women practicing an economic activity work in a nonagricultural informal sector to 63% for men [40].
According to Nelton [41], women do not seek to maximize profit, they are rather concerned with the quality of their enterprises’ output. This helps us to understand why their enterprises grow a little slower than men’s [43, 44]. This idea has been seen otherwise by Rosa, et al. [45]. These authors say that women do not seek to increase the size and/or the number of employees of their enterprises, they rather seek to perform their job well. Thus, one should not analyze women’s enterprises only in terms of profitability, but one should also and especially consider their efficiency. Brush [25] thinks that women are also efficient as men except that they do not know how to cheat in business. This is especially true as Dollar et al. [46] have shown that countries having a lot of women in their management departments are less corrupt. Johnson and Storey [47] have also shown that women’s enterprises are more stable than men’s on the long run. Rietz and Henrekson [48] show that even if men’s enterprises outsell women’s, there would not be any difference between them in terms of profitability.
The test of productivity difference between women’s enterprises and men’s enterprises is still then topical. Most of the previous studies were mainly limited by using domestic data that have covered several fields of activities. The reproach to these types of data is to have left out the fact that fewer women are often represented in some sectors. Even if we make use of a small sample like Rosa et al. [45] and Holmquist and Sundin [35], we have the advantage of possessing data collected in sectors of activity whereby women and men are frequently seen as owners of enterprises.
We use primary data collected in Ouagadougou to analyze informal enterprises’ performances with particular attention to gender. Our data have been collected from very small production units in such a way that their owners are almost poor. Thus, we shall make gender correspond only to sex. The main question we shall try to answer is as follows: After controlling by socioeconomic variables of the owner and by the characteristics of the business environment as well, is it possible to justify SMEs’ productivity difference and dynamism through gender?
In Ouagadougou, eight out of ten households get their income from an informal production unit [36]. When we consider the informal sector’s actors, we realize that women are well represented. We think that if their activities were not profitable, their number would have decreased with time. According to INSD’s statistics, in the informal sector in Ouagadougou, 47.3% of enterprises are set up and managed by women. However, on the level of employees, men were more paid than women. But, this is justified by the fact that men’s working hours (60 hours per week) are longer than women’s (51 hours per week). The objective of our analysis is consequently to test that women’s enterprises are more dynamic and more efficient than men’s enterprises. In order to succeed, we will analyze issues of enterprises’ growths through Evan’s model [37]. To derive these enterprises’ technical efficiency scores, we will use the stochastic frontier model by Mayers and Liu [38].
At the end of our analyses, we realized that our data support the assumption stating that women’s enterprises grow more rapidly than men’s enterprises. In general, we have also noticed that women’s enterprises are younger than men’s enterprises. In average, women’s enterprises technical efficiency is higher than men’s enterprises. Nevertheless, men’s enterprises employ more workers than women’s enterprises.
The remaining of the chapter is segmented as follows. Section II briefly recalls a few empirical results on the determinants of productivity difference between women and men. Section III presents the models of the dynamism analysis and the technical efficiency and the data as well. Section IV analyzes and discusses the results. The last section sums up the analysis’s results and makes a few recommendations to ensure the survival of women’s enterprises.
In literature, all the results seem to corroborate the fact that men’s enterprises perform better than women’s enterprises both in developing and developed countries. Johnson and Storey [47] show that from 289 enterprises’ data in Great Britain, women’s enterprises are smaller than men’s enterprises. From 400 enterprises’ data from three different industrial sectors, Kalleberg and Leicht [43] show that determinants of survival and success of enterprises in Indiana (USA) were independent from the owner’s sex. Other studies having been carried out in developed countries have also shown that women’s enterprises produce less incomes and even employ fewer workers than men’s enterprises [25, 49]. Even if it is accepted that there is a difference in women’s and men’s enterprises’ output, Kalleberg and Leicht [43] estimate that this productivity difference is overestimated when one uses national data. To reduce this overestimation, these authors recommend the use of data of the same sector of activity.
Certain studies carried out on data collected in developed countries have often supported the assumption that in some cases, women perform better than men. Carter and Cannon [42] have shown that even if women’s enterprises focus too much on qualitative aspects in a short term, quantitative performance indicators are also their concern on the long run. Rosa, et al. [45] have reached the results stating that when we consider small-sized enterprises (1–5 employees), we realize that women’s enterprises grow faster while for medium enterprises (more than 20 employees), men’s enterprises grow faster.
Education is the variable determining the survival of women’s enterprises in Africa. Chirwa [8] has got to the result that education improves informal enterprises’ profitability. Akouwerabou [50] has obtained an opposite result on a case study of Burkina Faso’s informal enterprises. The author justifies the fact that education affects negatively enterprises’ growth due to the fact that qualified owners are in the informal and looking for a job in the public service or in big enterprises. On data from Malawi, Chirwa finds out that women’s enterprises grow faster than men’s enterprises. This result is contrary to McPherson’s findings [51] in the case of South Africa. Akouwerabou [50] from Burkina Faso’s informal enterprises’ data and Chirwa [8] have found a reversed U relation between the informal enterprise’s profitability and its experience. This would signify that whether it belongs to a woman or a man, young enterprises grow less rapidly than the old ones.
Even if this seems to vary very quickly from a country to another, in Africa, we notice that on the scale of informal enterprises, women have more access to credit than men have. This is justified by the fact that microfinance is little developed, and it grants more credits to women than men in towns as well as in rural areas. In Malawi, Chirwa [8] finds out that women have more access to credit than men, while in South Africa, Abor and Biekpe [52] have got to an opposite result.
In the current analysis, we seek to test the hypothesis according to which men-owned enterprises perform more than women-owned ones. The purpose of the chapter is to show that the outcomes (dynamism and technical efficiency) of men-owned informal enterprises are better than women ones.
We use data collected within the framework of education production in informal activities. These data were collected by Western and Center of African Network for Research in Education1 and covered four activities branches in Ouagadougou. The informal sector activities covered by this survey are hairdressing salon, motor bike mechanics, sewing, and carpentry. In this study, we used only the data of hairdressing salon and sewing, which are the activities sectors where we meet men-owned and women-owned enterprises.
The survey was carried out in 2010 and related to 300 small production units in Ouagadougou. With the objective to prevent the production units to count in the same area, 60 informal production units were retained in each of the five districts of Ouagadougou. Informal production unit’s number per sub-category of activity is retained according to the representativeness of each sub-category activity according to the data collected by INSD in 2001 in the whole of Ouagadougou town [53]. Collected information are related to the employees number (at the activity starting year and in 2010) and their socio demographic characteristics (age, education level, the type of leasing contract established with the landlord, number of lost working days by the unit members due to disease, etc.)
From theoretical view, one can imagine that the efficiency of a microenterprise influences its dynamism and vice versa. Efficiency influences dynamism through the process of self-financing. When the micro enterprise is efficient, this helps it to achieve more cash flow and then more resource that will supply its self-financing. The past results (dynamism) of the enterprise also influence its current capacities through the process of learning by doing. A microenterprise that carried out good performances from the past must be able to do the same now. These relations may be summed up through the following system:
Where
The analysis of system Eq. (1) requires data of at least two periods. But, the data at our disposal are data of one passage. Consequently, we will replace
Evans [37] proposed to consider the enterprise growth as a function of its growth rate and its characteristics. The author estimates that the enterprise growth is mainly influenced by its initial size and age. Let G be the variable measuring the micro enterprise growth, we can write that:
In the relation Eq. (2),
Where
In the current study, we will suppose that
We suppose that the group of variables (entrepreneur’s education, entrepreneur’s experience in the domain and the number of employees who have a formal contract) have a positive influence on the dynamism of IPUs. As for the other two variables (share of unknown customers in the IPU’s earnings and the number of unemployed supported by the IPU), we expect that they affect negatively the microenterprise’s growth. When an entrepreneur of a microenterprise is supporting many inactive, the enterprise earnings are mostly used to satisfy family needs, which lower the capacity of self-financing. As the access to credit of microenterprises is very low, the use of enterprises’ earnings to support social expenditure negatively affects enterprise growth. Likewise, when the enterprise has very few loyal customers, its earnings fluctuate more, given that the demand addressed to it is totally unpredictable.
Table 1 descriptive statistics show that the number of employees varies between 1 and 8, and enterprises hiring the most are men’s enterprises. This implies that women’s enterprises grow less rapidly than men’s with regard to employment. In average, women’s enterprises hire five employees per year to six employees for men’s enterprises. At the starting of their activities, men’s enterprises even start with more employees than women’s. However, women’s enterprises are mostly younger than men’s enterprises. Considering the level of education, we realize that men have slightly gained this capital than women. Even the most experienced entrepreneurs in their field of activities are among men.
Variables | Sample | Women | Men | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Obs. | Mean | Std. Dev | Min | Max | Obs. | Mean | Std. Dev | Min | Max | Obs. | Men | Std. Dev | Min | Max | |
215 | .06 | .09 | −0.15 | .60 | 53 | .05 | .06 | −0.06 | .24 | 162 | .06 | .09 | −0.15 | .60 | |
215 | .26 | .21 | 0 | .85 | 53 | .25 | .21 | 0 | .60 | 162 | .26 | .21 | 0 | .85 | |
215 | .63 | .39 | 0 | 3.30 | 53 | .58 | .32 | 0 | 1.18 | 162 | .65 | .42 | 0 | 3.30 | |
215 | 60.74 | 28.09 | 0 | 100 | 53 | 47.08 | 28.88 | 0 | 90 | 162 | 65.22 | 26.41 | 0 | 100 | |
15 | 8.45 | 4.47 | 1 | 19 | 53 | 8.2 | 2.62 | 3 | 19 | 162 | 8.51 | 4.93 | 1 | 19 | |
215 | 3.76 | 3.16 | 0 | 0 | 53 | 3.08 | 2.50 | 0 | 10 | 162 | 3.98 | 3.32 | 0 | 20 | |
215 | .08 | .28 | 0 | 1 | 53 | .06 | .23 | 0 | 1 | 162 | .09 | .29 | 0 | 1 | |
215 | 10.77 | 6.28 | 0 | 35 | 53 | 8.51 | 4.51 | 0 | 23 | 162 | 11.51 | 6.59 | 0 | 35 |
Descriptive statistics of variables used in the growth model.
Source: build by the authors.
Roughly speaking, we can say that we have a sample that is a bit like Chirwa’s [8] in terms of human capital variables. In his study about Malawi, the author has got almost the same characteristics between women and men. Like Chirwa, we come to the conclusion that men outnumbered women in our sample. In fact, 66.1% of sewing and hairdressing enterprises managers having been surveyed are men. Women’s enterprises’ incomes depend more on their network of acquaintances. About 53% of customers of women’s enterprises are people who know personally the manager, whereas 65.2% of customers of men’s enterprises are unknown. We see here Okten and Osili’s [54] findings stating that women’s informal enterprises incomes are straightly linked to their relations network.
For the estimation of the technical efficiency scores, we suppose that we have
with
i.e., the effective production is at most equal to the potential production. In relationship Eq. (5),
By writing
The explanatory variables in relationship Eq. (6) are the labor (
We assume that the efficiency of a microenterprise increases with its number of qualified workers. This prediction is established on the hypotheses that theories of endogenous growth have expressed on the capacity of human capital to increase technical efficiency. However, increased levels of worker disease lead to less efficient enterprises. This hypothesis stems from the fact that the more the workers contract diseases, the less they work, thus leading to a decrease of the enterprise’s productivity. Finally, we assume that the more the entrepreneur of the micro-enterprise believes that his business is risky, the more efficient his enterprise is. If the entrepreneur believes that his business is too risky, he will expend more effort to minimize this risk. The efforts of minimization of risk are later converted into profit productivity.
Table 2 shows us that men’s enterprises generate more incomes than women’s enterprises. Nevertheless, women’s enterprises have got more physical capital than men’s enterprises. Women’s enterprises are mostly practicing in sewing and their employees contract diseases more than men’s employees. A great proportion of women (45%) thinks that doing business in the informal is more risky to 37% of men. Broadly speaking, employees in women’s enterprises are more skilled than men’s enterprises.
Variables | Sample | Women | Men | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Obs. | Mean | Std. Dev | Min | Max | Obs. | Mean | Std. Dev | Min | Max | Obs. | Men | Std. Dev | Min | Max | |
Log (sales) | 215 | 4.78 | .58 | 0 | 5.69 | 53 | 4.68 | .77 | 0 | 5.69 | 162 | 4.82 | .51 | 0 | 5.57 |
Log (labor) | 215 | .48 | .19 | 0 | .90 | 53 | .46 | .19 | 0 | .78 | 162 | .48 | .19 | 0 | .90 |
Log (capital) | 215 | 5.23 | .56 | 3.69 | 6.39 | 53 | 5.29 | .59 | 3.69 | 6.18 | 162 | 5.21 | .54 | 3.69 | 6.39 |
Illness | 215 | 25.28 | 20.43 | 0 | 100 | 53 | 31.30 | 22.19 | 0 | 100 | 162 | 23.31 | 19.49 | 0 | 90 |
Mobile phone | 15 | .94 | .24 | 0 | 1 | 53 | .91 | .29 | 0 | 1 | 162 | .95 | .22 | 0 | 1 |
Credit | 215 | .06 | .24 | 0 | 1 | 53 | .11 | .32 | 0 | 1 | 162 | .04 | .20 | 0 | 1 |
Hairdressing | 215 | .35 | .48 | 0 | 1 | 53 | .85 | .36 | 0 | 1 | 162 | .19 | .39 | 0 | 1 |
Sewing | 215 | 34 | .47 | 0 | 1 | 53 | .15 | 36 | 0 | 1 | 162 | .39 | .49 | 0 | 1 |
Risk | 215 | .39 | .49 | 0 | 1 | 53 | .45 | .50 | 0 | 1 | 162 | .37 | .49 | 0 | 1 |
Number of qualified employees | 215 | .08 | .28 | 0 | 1 | 53 | .06 | .23 | 0 | 1 | 162 | .09 | .29 | 0 | 1 |
Descriptive statistics of variables used in the stochastic frontier model.
Finally, the relationships that will be estimated are relationship Eq. (3) for the dynamism of the microenterprise and relationship Eq. (6) for the efficiency determinants. These estimations have been carried out with STATA 12.
In this section, we present and discuss econometric results. In the first section, we discuss results concerning determinants of enterprises’ growth. The second subsection presents and discusses determinants of enterprises’ technical efficiency.
By lining up enterprise’s growth and labor, we get a reversed u-relation between growth and women’s age. Young women’s enterprises grow more rapidly. In fact, the results show us that women aged less than 35 years are more dynamic than older women. As for men, starting an enterprise with a high number of employees negatively affects the enterprise’s dynamism. However, unlike women, young men’s enterprises grow less rapidly than older men. With regard to Table 3 significant coefficients, we can also say that men aged more than 25 years are capable of setting up and manage well a medium-sized informal enterprise. Men’s enterprises giving formal contracts to their employees are also more dynamic.
Variables | Sample | Women | Men | |||
---|---|---|---|---|---|---|
Coefficients | std. error | Coefficients | std. error | Coefficients | std. error | |
Log (labor at starting) | −0.234*** | 0.073 | −0.0839 | 0.130 | −0.434*** | 0.0869 |
Log (labor at starting) square | −0.140 | 0.102 | −0.0774 | 0.243 | −0.0575 | 0.112 |
Log (age) | −0.142*** | 0.034 | 0.296*** | 0.0887 | −0.270*** | 0.0412 |
Log (age) square | 0.024** | 0.012 | −0.296*** | 0.0886 | 0.0590*** | 0.0137 |
Log(Age)* Log (labor at startin | 0.200*** | 0.061 | −0.00546 | 0.136 | 0.377*** | 0.0690 |
Education_head | 0.001 | 0.004 | 0.00336 | 0.00378 | ||
Unknown_customers | 0.0002 | 0.0002 | 8.83e-05 | 0.000283 | 4.85e-05 | 0.000225 |
Age*Educ_head | −0.0001 | 0.0001 | −0.000102 | 0.000117 | ||
Unemployed | 0.003* | 0.002 | −0.00377 | 0.00324 | 0.00508** | 0.00220 |
Experience | −0.0001 | 0.001 | 0.00343 | 0.00209 | 0.000270 | 0.00110 |
Number of formal employees | 0.0513*** | 0.018 | 0.0371 | 0.0326 | 0.0603*** | 0.0199 |
Constant | 0.142*** | 0.021 | 0.0162 | 0.0268 | 0.223*** | 0.0304 |
Observations | 215 | 53 | 162 | |||
R-squared | 0.354 | 0.462 | 0.472 |
Determinants of the informal enterprises growth.
Legend: ***, ** and * imply significance at 1%, 5%, and 10%, respectively.
Table 2 has shown that women’s enterprises have got more physical capital than men’s enterprises. Based on Table 4 results, we can affirm that women’s enterprises are overequipped. Women’s enterprises’ level of equipment is higher than the optimal threshold which they needed. Both for women and men, we shall keep in mind that labor contributes more to improving productivity compared to capital. Our assessments show that credit does not affect men’s technical efficiency. Nevertheless, it harms women’s enterprises’ technical efficiency. This result is in contradiction with the result of Marlow and Patton [55] who have shown that access to credit improves women’s informal enterprises’ performances. The fact of managing an enterprise in a very risky field of activity lessens women’s technical efficiency. However, doing business in a risky field of activity is profitable to men. When employees in the enterprise lose working hours due to sicknesses, it negatively affects enterprises’ productivity irrespective of the owner’s gender.
Variables | Sample | Women | Men | |||
---|---|---|---|---|---|---|
Coefficients | std. error robust | Coefficients | std. Error robust | Coefficients | std. error robust | |
Production function | ||||||
log_lab | 0.295** | 0.135 | 1.357*** | 2.23e-08 | 0.248*** | 1.39e-08 |
log_capital | 0.119** | 0.0487 | −0.0503*** | 5.45e-09 | 0.0436*** | 6.24e-09 |
Constant | 4.479*** | 0.235 | 5.061*** | 1.97e-08 | 5.146*** | 3.87e-08 |
Efficiency function | ||||||
illnes | −0.0122 | 0.00847 | −0.0308** | 0.0153 | −0.0164*** | 0.00538 |
m_phone | 0.812* | 0.472 | 2.687*** | 0.705 | 0.232 | 0.481 |
credit | −0.176 | 0.462 | −0.935* | 0.542 | −0.0616 | 0.470 |
coif | 0.716* | 0.414 | 0.241 | 0.360 | 0.123 | 0.224 |
age | −0.0743*** | 0.0270 | −0.118*** | 0.0457 | −0.0251 | 0.0153 |
risk | 0.691** | 0.308 | −1.007** | 0.508 | 0.851*** | 0.177 |
contrat_formel | −1.489* | 0.781 | −3.041*** | 0.850 | −0.253 | 0.352 |
dy | −2.504 | 3.141 | 5.771 | 3.931 | −3.256 | 2.600 |
Constant | −0.0122 | 0.00847 | 1.803 | 1.731 | 0.255 | 0.777 |
Function of variance | ||||||
Γ | −3.925*** | 0.252 | −35.92*** | 0.115 | −36.14*** | 0.0686 |
Observation | 215 | 53 | 162 |
Determinants of enterprises productivity and inefficiency.
Legend: ***, ** and * imply significance at 1%, 5% and 10%, respectively.
In our sample, women’s enterprises are not less equipped than men’s enterprises contrary to the data of De Mel et al. [22] and Banerjee and Sendhil [15]. Nevertheless, we find out that they are inefficient in choosing the level of production factors. Women overinvest in physical capital with regard to the size of the enterprise. Moreover, contrary to the findings of Wasihun and Paul [20] who estimate that women have less access to credit compared to men, we have found out that women’s access rate to credit is higher than men’s. During the last 10 years, microfinance has been developed rapidly in developing countries. But, it has been shown that in Burkina Faso, microfinance institutions grant more credit to women than men [56]. Our data actually corroborate Minguez-Vera and Martin [26] who said that women are less efficient compared to men in risky fields of activities. However, we have found out that labor is more productive in women’s enterprises contrary to Chowdhury and Amin result (2011).
Women’s access to credit does not help them to increase their enterprises’ productivity. Instead of using the credit to facilitate their enterprises’ activities, women often tend to use the credit for consumption items. They get into debt on behalf of their enterprises to insure their families’ consumption expenses. Then, they use their enterprises’ incomes to pay the credit back [57]. This explains why women who have access to credit are less productive.
Graph 1 shows that in average, women’s enterprises are as efficient as men’s enterprises. The curve representing women’s enterprises level of technical efficiency is even sometimes on top of men’s own. This implies that women are as efficient as men in the informal sector [25]. Thus, by limiting oneself to sales analysis, one can say women are less efficient than men (Table 2). Authors like Cuba et al. [49] have drawn conclusions from this type of information that women are less efficient than men. But, in fact, even if women get fewer incomes in comparison to men, they are more efficient than men. Table 1 descriptive statistics have even shown that their enterprises are more stable than men’s enterprises. This table’s data show that the minimum growth of women’s enterprises is −.06, whereas men’s enterprise is −.15. This implies that enterprises having laid off more employees, since their creations are found among men’s enterprises. This result has also been highlighted by Johnson and Storey [47]. From our view point, the fact of women becoming less skillful is deplorable in the enterprise management as they become older.
Technical efficiency scores with regard to the gender of the promotor. Source: Build by the authors.
Women have long been hindered from setting up and managing their own businesses. After several dozens of political and economic years of efforts, some women have got freedom to do business. Today, the new concern of economists is to know if women are less efficient than men. The first analyses have actually got to the findings that men’s enterprises are more profitable than women’s enterprises [58, 59].
In this chapter, we have used data from informal enterprises to contribute to this debate. Studies that have shown that women are less efficient than men have gone under a lot of criticisms regarding the quality of data they have used. These studies have mostly used data, whereby women and men do business in different fields of activities. The difference of the sector of activity then prevents to clearly see the impact of gender on performances. Others have also sometimes used data, whereby men run formal enterprises, while women are in the informal. We have used data, whereby women and men practice the same activities.
We have found out that it is more profitable for a woman to set up and manage an enterprise while she is young. However, young men succeed less in entrepreneurship. Unlike then to women, men need to get more experiences in their sector of activities before becoming efficient. This allows to justify why in our sample, women’s enterprises are younger than men’s enterprises (Table 1). Women’s enterprises employ less workers than men’s enterprises and get less income than men’s enterprises.
Women’s enterprises are however more efficient than men’s enterprises. Women’s enterprises technical efficiency scores are slightly superior to men’s enterprises scores. Moreover, in terms of vulnerability, women’s enterprises are more stable than men’s enterprises. We have found out that the frequency of redundancy is higher in men’s enterprises.
In order to succeed in entrepreneurship, we advise women to start when they are younger. Even if the development of microfinance in developing countries facilitates them the access to credit, it will be profitable that women index the request of credit to their enterprises’ needs. In fact, they should not apply for credit given the easy access to credit, but they should rather do it when their enterprises really need it. Therefore, to better understand why the access to credit negatively affects women’s enterprises’ technical efficiency, it will be profitable to investigate on the determinants of the credit application by entrepreneur women in the informal sector.
Meningiomas are the most common primary intracranial tumors accounting for 20% of all intracranial neoplasms. Sphenoid wing meningiomas (SWM) account for 11%-20% of all intracranial meningiomas. Meningiomas of the anterior clinoid process (MAC) comprise about 34.0–43.9% of all sphenoid wing meningiomas. There is female prevalence among patients [1, 2, 3].
The challenges start with the definition of MAC. From the early beginning, H. Cushing and Eisenhardt in 1938 were the first to divide SWM into globoid tumors with a nodular shape and en plaque tumors, which are flat and spread along the sphenoid wing [2]. The globoid tumors were then categorized into lateral, middle, and medial. The last group could be classified as MAC. In accordance with Al-Mefti, MAC was classified into 3 groups according to the side of their origin on the surface of the clinoid process. First group meningiomas arise from the subclinoidal dura at the most proximal point of intradural entry of the internal carotid artery, before the carotid enters into the arachnoidal cisternal space. The second group clinoidal meningiomas originates from the superolateral aspect of the anterior clinoid process. The third group originates from the region of the optic foramen and extends into the optic canal [1, 4]. Many authors consider this classification hard to apply in daily practice. Russell & Benjamin took into account the invasion of the tumor into the lesser sphenoid wing and spread into the cavernous sinus [3]. Both parameters have great practical significance in surgical approach planning [5].
The exclusion method is also useful to identify the MAC. All paraoptic meningiomas such as tuberculum sella, diaphragm, cavernous sinus, planum sphenoidale, as well as spheno-orbital are recognizable with their specific findings [6, 7, 9]. We consider the presence of the anterior clinoid process in the center of the tumor bone attachment to be the main feature of clinoidal meningiomas (Figure 1). The second apparent peculiarity is the paramedian location of the tumor and consequently the displaced ipsilateral optic nerve, III nerve, and the ICA toward the midline [8, 9, 10].
Anterior clinoid bone anatomy, right side. 1 – Optic canal; 2 – Superior orbital fissure; 3 – Anterior clinoid process.
Anterior clinoid process (ACP) is tetrahedron in shape with the apex projected medio-posteriorly. Medially, it forms a superolateral wall of the optic canal. The optic strut is the posterior root of the ACP. Anteriorly it continues with the medial aspect of the sphenoid ridge.
As a rule, the process comprises the bony cortex. However, its pneumatization and bony connections could be variable and attention should be paid before the planned removal.
The removal of the process reveals the 2-6 cm long clinoid space [10]. The dural layer between this space and ACP is the deep extension from the roof of the cavernous sinus and covers the inferior surface of the clinoid process. Medially, this layer extends to surround the ICA as the proximal dural ring and turns upward along the clinoid segment of the ICA to fuse with the distal dural ring. The dural connection between the 3rd nerve and the lateral aspect of the distal dural ring is called the carotico-oculomotor membrane. From the inferolateral aspect of the ACP, the neural bundle consisting of 3rd, 4th, 6th and three branches of the ophthalmic nerve are running. Thus, manipulation in the inferior direction exposes these structures to danger and should be avoided [11, 12]. Meningiomas usually invade the outer (temporal) dural leaf and rarely spread to dura propria (DP), so the separation of dural leaves during surgery provides an increased removal rate as well as better visualization of anatomical structures [13, 14].
C2 and C3 segments of ICA (Bouthillier nomenclature) are traversing the horizontal and vertical portion of the carotid canal in the petrous bone. The cavernous C4 segment is forming a carotid siphon, surrounded by venous plexus. This portion ends with the dural entrance through the proximal dural ring. The number of veins surrounding the clinoid meningioma is not constant. The superficial middle cerebral vein (SMCV) drains the lateral part of the cerebral hemisphere into the cavernous sinus (CS) directly by penetrating its lateral wall and indirectly through the sphenoparietal sinus or through the latero-cavernous sinus. Sphenoparietal sinus runs medially just below the lesser sphenoid wing to empty into the anterior part of the CS [15, 16].
Understanding of ACP syntopy with surrounding anatomical structures is extremely important for surgical dissection and anterior clinoidectomy during surgery. The base of the process forms the lateral and lower walls of the optic canal, the medial surface forms the ICA canal, and the lateral surface and optic strut are the parts of the upper medial wall of the upper orbit (Figure 1). Thus, ACP is located between the canal of the optic nerve, upper orbital fissure, and ICA canal. Extradural resection of the process provides the access to these bony channels and their content. The clinoidal process also separates two leaves of the dura: dura temporalis (DT) and DP. DP represents the lateral wall of the cavernous sinus and extends from the outer to the inner dural rings, where the ICA penetrates the cavernous sinus. Also, it touches the free edge of the tentorium in posterior divisions, which is fixed to the apex of the ACP [17]. Anteriorly it continues to the layers of the upper orbit. It should be remembered that ACP meningiomas usually invade the outer leaf of the dura and very rarely are spread to the DP. Thus, the separation of the dural leaves during surgery allows exposure of the lateral surface of the ACP and provides consequent visualization of the important anatomical structures of the skull base [17, 18].
After performing extradural clinoidectomy, the optic nerve in the dural sheath could be visualized [19, 20]. The lateral wall of the cavernous sinus and the intracavernous part of the ICA that is passing behind are seen as well. The 3rd nerve is located immediately below the projection of the lower clinoidal edge. The 1st branch of the V nerve passes lower.
Variable pathological anatomy of this area due to tumor growth has to be taken into account. Most clinoid meningiomas invade ACP causing its hyperostotic enlargement [21, 22]. Thus, anterior clinoidectomy is considered the key to the radicality of surgery.
However, there is a group of meningiomas that grows from the superior or superolateral surface of the clinoid without invasion into the ACP and hyperostosis does not exist [23, 24, 25]. Complete clinoidectomy is not necessary for this type of MAC.
Intradural syntopy in presence of MAC is much more complex and variable in comparison with extradural peculiarities. Primarily, it is due to the nature of meningioma spread, that has two patterns: expansive and invasive. The first type has a small fixation area and the tumor “wraps” around vessels and nerves. Invasive type spreads along the dura and longitudinally ingrowth into the anatomical structures [26]. In practice, a combination of both types with some predominance is usually seen.
The important tip is to follow the olfactory nerve that always leads to the optic nerve if the last is markedly displaced by the tumor.
A1 segment of ACA and all anterior semicircle of Willis are shifted medially and located on the dorsomedial surface of meningioma. M1 segment of MCA “rolls over” through the dome of the tumor on its upper lateral surface. Special attention to perforating and small branches of the anterior circle of Willis should be paid because of their tight inclusion in the tumor [27]. Sharp dissection is the only possible method to separate them from the tumor.
The oculomotor nerve is displaced dorso-medially and could be encased by neoplasm.
The pituitary stalk itself is not commonly involved in MAC, located on the postero-medial portion of meningioma, and could be separated without difficulties. Although, the superior hypophyseal artery has a variable way and has to be saved to prevent postoperative diabetes insipidus.
Despite the fact that advanced imaging techniques are more accessible and have advantages in certain scenarios, the computed tomography and MRI routine scans remain the standard investigations for patients with MAC [28]. Hyperostosis, bone structures, and anatomical syntopy could be assessed with standard protocols. CT is informative in assessing the bony structures of the skull base, especially anterior clinoid hyperostosis, as well as to determine the presence of petrifications in the tumor. This examination is routinely performed the next day after surgery to control the extent of the tumor removal and exclude the hematoma.
Some features are associated with more aggressive meningiomas and include increased signals on both T1- and T2-weighted MRI, irregular contour, extensive edema, lack of calcifications, central necrosis, and low apparent diffusion coefficient [29]. However, if normal anatomy is variable, the more challenging pathological anatomy influenced by the tumor makes the strategy individual.
Attention should be paid to the tumoral entrapment of the supraclinoid part of the ICA. The ICA is “enveloped” and can
Thus, we tend to divide MAC into two main types. The first includes tumors that do not invade the anterior clinoid process and grow expansively into the cranial cavity. Type II meningiomas involve the ACP, spread into the CS, and concentrically entrap the supraclinoid segment of the ICA. There is a sense to separate the second subgroup of tumors: with the penetration to the CS and without it. Anatomical criteria for distribution are demonstrated in Table 1 and Figures 2–4.
Type I | Type IIA | Type IIB | |
---|---|---|---|
Anterior clinoid process hyperostosis | — | + | + |
Cavernous sinus invasion | — | — | + |
Internal carotid artery entrapment | Shifting / Wrapping | Wrapping / Adhesion | Concentric encasement |
Needed clinoidectomy | Partial | Total | Total |
Surgical approach | Fronto-lateral* intradural | Pterional extradural | Pterional extradural |
Criteria for distribution of sphenoid meningiomas.
In absence of peritumoral edema.
Type I sphenoid meningioma.
Type IIA sphenoid meningioma.
Type IIB sphenoid meningioma.
Many surgeons recommend performing angiography before surgery to determine the tumor’s blood supply and venous features. We totally agree with the expediency of this study, however, we would not insist on the absolute need to conduct it to all patients with this pathology.
According to the literature, several surgical approaches are used to remove sphenoid meningiomas: subfrontal, fronto-lateral, fronto-temporal intradural, pterional, fronto-temporo-orbito-zygomatic [14, 31, 32]. Eyebrow incision supraorbital keyhole approach (essential modification of the standard frontal-lateral/supraorbital) could be used as well [33]. Recently, several authors have reported their experience using this approach in the management of tumorous lesions around the sellar region [34, 35].
We are using two surgical approaches in our practice: fronto-lateral supraorbital and pterional. The advantages and disadvantages of both approaches are presented in Table 2.
Fronto-lateral | Pterional | |
---|---|---|
Surgical corridor | Intradural | Extradural |
Clinoidectomy | Intradural partial | Extradural |
Exposure of optic nerve and internal carotid artery | Intradural after dissection and debulking of tumor | Extradural before the tumor dissection |
Meningioma devascularization | During the removal | Mainly before the removal |
Need for Sylvian fissure dissection | + | — |
Need for cerebral traction | Frontal lobe | Minimal due to protective dura |
Advantages and disadvantages of pterional and fronto-lateral approaches.
In general, the patient’s body should be strictly fixated despite the chosen approach to allow the operative field position and angles change. A rigid fixation of the head in the Mayfield or Sugita skull clamp should be used. We have abandoned the use of lumbar drainage to relax the brain during surgery. All surgeries are performed under general anesthesia with artificial lung ventilation.
The head is turned away from the side of the craniotomy and the neck should be extended so that malar eminence is at the highest point of the operative field to allow gravity to facilitate brain retraction. The neck should be positioned to avoid excessive compression of jugular veins and the endotracheal tube. Elevation of the head of the bed and ipsilateral shoulder elevation with a pad is used to ensure adequate jugular venous return. The hair is shaved, extending for 3 cm behind the hairline. Skin is incised in a curvilinear fashion from 1 cm anterior to the tragus to the midline. Temporalis muscle is divided by electrocautery and the myocutaneous flap is reflected anteriorly and inferiorly by the subperiosteal dissection with the periosteal elevator and minimal electrocautery, until the root of the zygoma, keyhole, and supraorbital ridge are identified. Posteriorly, the temporalis muscle is retracted for additional temporal exposure.
Adjacent to the Sylvian fissure parts of the frontal and temporal lobes should be widely exposed during the trepanation window formation. The extradural stage includes pterion and lateral orbit drilling. The meningo-orbital band is cut. Dura propria and temporalis are separated from each other. The removal of hyperostotic ACP is impossible without this maneuver. MAC usually involves only temporal dura, thus DP serves as a great orientation layer covering cavernous sinus and protecting its structures during dissection. Intraoperative ultrasound investigation and neuromonitoring should be used during this stage to ensure the ICA and adjacent III and V1 nerves location. Before the intradural stage, it is necessary to visualize the optic nerve in the dural sheath, ICA, and the lateral wall of the cavernous sinus. Arcuate dural incision along the tumoral border allows to use the proximal undamaged dura as brain protection. Incision prolongs to the dura that rostrally covers the optic nerve and then along the upper edge of the cavernous sinus caudally. The edges are connected along the upper part of the cavernous sinus. Mobilized shred is removed together with the adjacent tumor (Figure 5).
Final view after tumor removal, right side. 1 – Drilled optic canal 2 – Incised dura around the optic nerve 3 – Optic nerve 4 – Brain tissue 5 – Internal carotid artery 6 – Dural edge 7 – Posterior communicant artery 8 – Oculomotor nerve 9 – Distal dural ring 10 – Superior orbital fissure (connected with optic canal) 11 – Drilled clinoid base; A and B – Preoperative MRI; C – Preoperative CT; D – Preoperative 3D CT bone reconstruction; E – Postoperative 3D CT bone reconstruction.
At this stage, the ON and supraclinoid segment of the ICA could be visualized. Markedly deprived from the blood supply, the tumor is debulked. Incrementally, the tumor is dissected from ON, chiasm, pituitary stalk, 3rd nerve, bran surface, ICA, PCA, ACA, MCA, and their branches in a sharp manner. Wound hermitization could be conducted with fat or vascularized galeo-aponeurotic flap.
The position of the patient is on his back. The head is raised and turned by 30° from the approach side. The skin incision is performed along the edge of hair growth. The musculocutaneous flap is directed toward the superciliary arch. Supraorbitally, a bone flap of approximately 5x3 cm is formed. Avoidance of frontal sinus opening is important and the mucous membrane should be dissected from the bone and sutured by atraumatic sutures if opened. Following the arcuate dural incision, CSF aspiration during Sylvian fissure dissection provides the brain’s relaxation and wide working space. There is a tendency to avoid using a retractor for the frontal lobe. Even if needed, the use should be as the “brain holder” but not for the forced retraction. Tumor dissection is started from the attachment point and after the ICA, 2nd and 3rd nerves visualization the separation from the basal attachment could be safely ended. Following the main arterial supply deprivation, the tumor usually becomes softer and the volume reduction is effectively conducted. This step allows crucial structures to release. The superior and lateral surface of the anterior clinoid bone as well as the optic nerve roof should be skeletonized by excision of the involved dura. The optic canal is opened necessarily and the anterior clinoid process is drilled within its tumor germination. The procedure is ended with the hermetic dural suturing, fixation of the bone flap, and suturing of the skin.
Skull base surgery is technically complex and requires special training of the entire neurosurgical team. The procedure should be performed step by step, as each subsequent stage is possible only after the perfect execution of the previous ones. This form of organization as well as applying general principles of craniobasal surgery prevents the majority of surgical complications [36, 37]. Today, mortality after sphenoid wing meningioma surgery does not exceed 1.2% (0.6-1.8%).
In addition to technical aspects, the correct position of the body and head, the presence of neuronavigation and the intraoperative neuromonitoring system accompanied with a well-prepared neurophysiologist are no less important [38, 39]. The confidence with a set of special micro instruments and its appropriate application is crucial. Co-working with anesthesiologists is of great importance in managing the brain edema and consequences of nerves, meninges, and other immediately reactive structures irritation.
The most common complications after the removal of the sphenoid wing meningioma are deterioration of vision, 3rd nerve damage, vascular accidents due to vessels injury, and CSF leakage [36].
Visual impairment is usually the first and main symptom and the primary goal of surgery is to preserve and improve the visual function of these patients.
Thus, early extradural visualization following the anterior clinoidectomy and intensive irrigation while drilling to prevent thermal damage is extremely important.
Dissection of the optic nerve sheath, as well as the falciform ligament, allow to explore the nerve in the optic canal, remove the intracanal portion of the tumor, and to ensure the complete ON decompression in the bone canal. Subsequent intracranial dissection from the tumor should be gentle to cause minimal injury of the ON and chiasm.
Early visualization of the ON is challenging in the case of the intradural fronto-lateral approach as it is covered with a tumor. The fixation point of MAP often extends to the roof of the optic canal. The risk of thermal damage of the optic nerve is high during the attachment site coagulation. We coagulate and separate the meningioma not directly along the basal dura, but retreating a few millimeters into the tumor mass. This maneuver lowers the risk of ON sacrifice. Ophthalmic nerves could serve as a landmark to find the 2nd nerve as I and II nerves as they are always overcrossing.
The oculomotor nerve has a low tolerance to any traumatic impact, so the violation of its function is possible even in the absence of direct manipulation with it during surgery. Nevertheless, if the 3rd nerve has not suffered serious traumatic impact intraoperatively, its function will be restored within 1-3 months postoperatively.
In contrast to pterional, the risk of damage to the 3rd nerve is minimal via the fronto-lateral approach. The oculomotor nerve passes directly below the lower edge of the wing, so clinoidectomy and separation of the two dural leaves could be harmful. Attentive dissection of DP and DT along with the plan, adequate irrigation, and coagulation avoidance in this area provide a better chance to pass by troubles.
The intracranial area of the 3rd nerve can be visualized after removal of the germinated basal dura. Sometimes it is appropriate to cut the 3rd nerve meningeal canal, to reach the tumor in the CS.
Detection of the ICA is challenging because it is covered with a tumor. The point is to estimate the character of MAP adhesion to the arterial wall as early as possible. Intimate fusion makes surgical separation impossible because of the risk of arterial wall damage. The so-called “proximal control” proposed by Al-Mefty is not frequently used nowadays. Comparing two approaches in the context of ICA damage risk, the intradural approach is more dangerous because of the need to go through the mass of the tumor to reach the artery wall without having a plan for dissection. In contrast, the extradural approach provides the opportunity to assess the degree of adhesion by early detection of the ICA in CS using intraoperative Doppler and visualize it at the level of the distal dural ring.
The presence of circular ingrowth of the ICA by the tumor cast doubt on attempts to separate them. Consequently, the sharp dissection of all involved vessels of the circle of Willis is preferred.
Venous anatomy in this region is extremely variable. They are always full-blooded and are at high risk of being damaged. The CS is a complex of venous channels. Due to the variability of the functional role of each vein, the excision of the tumor should be conducted with maintaining the integrity of the veins. They should be cut only if there is a confidence that the vein drains the tumor. Sylvian veins could be directly drained into the CS [15].
Sphenoid wing meningiomas are the group of tumors where the advantages of cranial base surgery over conventional transcranial surgery can be clearly demonstrated. The introduction of craniobasal approaches, which evolved from the fronto-temporal to the pterional and the fronto-temporo-orbito-zygomatic, and from the unilateral subfrontal to the fronto-lateral supraorbital, significantly reduces both the mortality and postoperative complications rate. Thus, in the 1970s postoperative mortality was up to 43% in some reports [37]. In contrast, nowadays less than 2% are reported [36]. The complication rate is dependent on involved structures and surgical approach but has markedly fallen over during the recent decades.
Analysis of the factors influencing the postoperative prognosis showed that histopathological characteristic of meningioma is one of the main determinants. Around 70% of meningiomas are benign (WHO grade I), while 28% are atypical (WHO grade II), and 2% are malignant (WHO grade III) [40]. Despite these well-known prognostic groups, meningiomas could have up to 15 different histologic subtypes. These characteristics are marked prognostic predictors and define the treatment strategy.
Anterolateral skull base and convexity meninges are derived from the neural crest, but the rest of the skull base has mesenchymal origin (paraxial mesoderm and dorsal mesoderm) [41]. This correlates with different histological subtypes of tumors and even WHO grades. Interestingly, the recent studies demonstrate the link between topography (meaning mesenchymal or neural crest origin) and the main somatic gene mutations [42].
The radicality of the removal is the next important prognostic factor. However, the introduction of radiosurgical treatment of the residual tumor of the skull base has significantly decreased the recurrence rate in the described group [42, 43].
Surgical resection of MAC is the treatment of choice, but in some cases, surgery alone may not be radical due to the tumor invasion to the CS, ICA, and/or ON encasement. Subtotal resection with adjuvant postoperative radiotherapy may be preferable over complete resection.
High-dose fractionated radiotherapy and radiosurgery have been reported to achieve a tumor control rate between 93–97% and 91–98%, respectively [43]. Permanent complications after radiosurgery are rare and have been reported in 0–10.5% of patients. They mainly consist of delayed optic nerve neuropathy, trigeminal nerve dysfunction, cognitive deficits, and seizures [44]. Functional results after radiosurgery for meningiomas involving the CS have proved to be superior to those obtained after microsurgical resection. [45]
The growth pattern in progressive benign meningiomas after failed radiosurgery can be unusually aggressive. In the case of reoperation after radiotherapy, it is associated with a higher complication rate compared to primary procedures [46].
Despite the great variety of existing approaches, the pterional extradural is the most common “workhorse” for meningiomas of the anterior clinoidal process excision. If there is no clinoid process hyperostosis and cavernous sinus invasion, the fronto-lateral approach will be an option. Overall, total clinoidectomy is the key procedure for visualization of all important structures during an extradural way to the tumor. All the peculiarities should be taken into account to move safely and prevent the thermal and mechanical injury of neural and vascular structures. Radicality of excision is limited by the ICA encasement rate and character, the cavernous sinus invasion, and an anterior semicircle of Willis ingrowth. Preserving the integrity of perforating arteries and surrounding veins is the main key to preventing complications. Finally, the radicality of surgery will never exceed the value of the functional result of surgery and the patient’s postoperative quality of life.
The authors declare no conflict of interest.
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They are considered as the biotechnologically valuable bacteria that are exploited for its secondary metabolite production. Approximately, 10,000 bioactive metabolites are produced by Actinobacteria, which is 45% of all bioactive microbial metabolites discovered. Especially Streptomyces species produce industrially important microorganisms as they are a rich source of several useful bioactive natural products with potential applications. Though it has various applications, some Actinobacteria have its own negative effect against plants, animals, and humans. On this context, this chapter summarizes the general characteristics of Actinobacteria, its habitat, systematic classification, various biotechnological applications, and negative impact on plants and animals.",book:{id:"5056",slug:"actinobacteria-basics-and-biotechnological-applications",title:"Actinobacteria",fullTitle:"Actinobacteria - Basics and Biotechnological Applications"},signatures:"Ranjani Anandan, Dhanasekaran Dharumadurai and Gopinath\nPonnusamy Manogaran",authors:[{id:"48914",title:"Dr.",name:"Dharumadurai",middleName:null,surname:"Dhanasekaran",slug:"dharumadurai-dhanasekaran",fullName:"Dharumadurai Dhanasekaran"}]},{id:"37734",doi:"10.5772/46006",title:"Endosomal Escape Pathways for Non-Viral Nucleic Acid Delivery Systems",slug:"endosomal-escape-pathways-for-non-viral-nucleic-acid-delivery-systems",totalDownloads:7415,totalCrossrefCites:33,totalDimensionsCites:91,abstract:null,book:{id:"2617",slug:"molecular-regulation-of-endocytosis",title:"Molecular Regulation of Endocytosis",fullTitle:"Molecular Regulation of Endocytosis"},signatures:"Wanling Liang and Jenny K. 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They are considered as the biotechnologically valuable bacteria that are exploited for its secondary metabolite production. Approximately, 10,000 bioactive metabolites are produced by Actinobacteria, which is 45% of all bioactive microbial metabolites discovered. Especially Streptomyces species produce industrially important microorganisms as they are a rich source of several useful bioactive natural products with potential applications. Though it has various applications, some Actinobacteria have its own negative effect against plants, animals, and humans. On this context, this chapter summarizes the general characteristics of Actinobacteria, its habitat, systematic classification, various biotechnological applications, and negative impact on plants and animals.",book:{id:"5056",slug:"actinobacteria-basics-and-biotechnological-applications",title:"Actinobacteria",fullTitle:"Actinobacteria - Basics and Biotechnological Applications"},signatures:"Ranjani Anandan, Dhanasekaran Dharumadurai and Gopinath\nPonnusamy Manogaran",authors:[{id:"48914",title:"Dr.",name:"Dharumadurai",middleName:null,surname:"Dhanasekaran",slug:"dharumadurai-dhanasekaran",fullName:"Dharumadurai Dhanasekaran"}]},{id:"35104",title:"Restriction Fragment Length Polymorphism Analysis of PCR-Amplified Fragments (PCR-RFLP) and Gel Electrophoresis - Valuable Tool for Genotyping and Genetic Fingerprinting",slug:"restriction-fragment-length-polymorphism-analysis-of-pcr-amplified-fragments-pcr-rflp-and-related-te",totalDownloads:34152,totalCrossrefCites:6,totalDimensionsCites:28,abstract:null,book:{id:"1770",slug:"gel-electrophoresis-principles-and-basics",title:"Gel Electrophoresis",fullTitle:"Gel Electrophoresis - Principles and Basics"},signatures:"Henrik Berg Rasmussen",authors:[{id:"114068",title:"Dr.",name:"Henrik",middleName:null,surname:"Rasmussen",slug:"henrik-rasmussen",fullName:"Henrik Rasmussen"}]},{id:"50471",title:"Molecular Mechanisms of Skin Aging and Rejuvenation",slug:"molecular-mechanisms-of-skin-aging-and-rejuvenation",totalDownloads:5175,totalCrossrefCites:6,totalDimensionsCites:13,abstract:"The aging process in the skin is complex and influenced by more intrinsic and extrinsic factors than any other body organ. The effects of these two types of factors overlap for the most part. The combined effects of these two aging processes also affect dermal matrix alterations. The main clinical signs of skin aging include wrinkling and irregular pigmentation, which are influenced by a combination of intrinsic and extrinsic (e.g., UV radiation, heat, smoking, and pollutants) factors. Histologically, collagen decreases, and the dermis is replaced by abnormal elastic fibers as a cause of wrinkle formation through the loss of skin elasticity. There have been numerous studies of skin aging performed to elucidate the underlying molecular mechanisms and to develop various antiaging therapeutics and preventive strategies. We summarized the molecular mechanisms and treatments of skin aging. Mainly UV radiation induces ROS formation and DNA damage, leading to increased production of MMPs and decreased production of collagen in keratinocytes and fibroblasts, which reflect the central aspects of skin aging. Besides UV radiation exposure, extrinsic factors including tobacco smoking, exposure to environmental pollutants, infrared radiation, and heat contribute to premature skin aging. Like UV radiation, these factors cause ROS formation and increase expression of MMPs, thus accelerating skin aging by inducing extracellular matrix (ECM) degradation. Accumulated collagen fibrils inhibit the new collagen synthesis and account for the further degradation of the ECM through this positive feedback loop. Accumulating evidence for molecular mechanisms of skin aging should provide clinicians with an expanding spectrum of therapeutic targets in the treatment of skin aging.",book:{id:"5258",slug:"molecular-mechanisms-of-the-aging-process-and-rejuvenation",title:"Molecular Mechanisms of the Aging Process and Rejuvenation",fullTitle:"Molecular Mechanisms of the Aging Process and Rejuvenation"},signatures:"Miri Kim and Hyun Jeong Park",authors:[{id:"47695",title:"Prof.",name:"Hyun Jeong",middleName:null,surname:"Park",slug:"hyun-jeong-park",fullName:"Hyun Jeong Park"},{id:"185767",title:"Prof.",name:"Miri",middleName:null,surname:"Kim",slug:"miri-kim",fullName:"Miri Kim"}]},{id:"62731",title:"An Introductory Chapter: Secondary Metabolites",slug:"an-introductory-chapter-secondary-metabolites",totalDownloads:9842,totalCrossrefCites:35,totalDimensionsCites:56,abstract:null,book:{id:"6670",slug:"secondary-metabolites-sources-and-applications",title:"Secondary Metabolites",fullTitle:"Secondary Metabolites - Sources and Applications"},signatures:"Durairaj Thirumurugan, Alagappan Cholarajan, Suresh S.S. Raja and\nRamasamy Vijayakumar",authors:[{id:"176044",title:"Dr.",name:"Ramasamy",middleName:null,surname:"Vijayakumar",slug:"ramasamy-vijayakumar",fullName:"Ramasamy Vijayakumar"}]},{id:"12955",title:"Organochlorine Pesticides in Human Serum",slug:"organochlorine-pesticides-in-human-serum",totalDownloads:8209,totalCrossrefCites:6,totalDimensionsCites:10,abstract:null,book:{id:"32",slug:"pesticides-strategies-for-pesticides-analysis",title:"Pesticides",fullTitle:"Pesticides - Strategies for Pesticides Analysis"},signatures:"Jung-Ho Kang and Yoon-Seok Chang",authors:[{id:"15477",title:"Dr.",name:"Yoon-Seok",middleName:null,surname:"Chang",slug:"yoon-seok-chang",fullName:"Yoon-Seok Chang"},{id:"16817",title:"Dr.",name:"Jung-Ho",middleName:null,surname:"Kang",slug:"jung-ho-kang",fullName:"Jung-Ho Kang"}]}],onlineFirstChaptersFilter:{topicId:"59",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. 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He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. 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He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. 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He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. 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