Computational time needed to run MUSIC for various numbers of sensors.
\\n\\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"2057",leadTitle:null,fullTitle:"E-Learning - Organizational Infrastructure and Tools for Specific Areas",title:"E-Learning",subtitle:"Organizational Infrastructure and Tools for Specific Areas",reviewType:"peer-reviewed",abstract:"Technology development, mainly for telecommunications and computer systems, was a key factor for the interactivity and, thus, for the expansion of e-learning. This book is divided into two parts, presenting some proposals to deal with e-learning challenges, opening up a way of learning about and discussing new methodologies to increase the interaction level of classes and implementing technical tools for helping students to make better use of e-learning resources. In the first part, the reader may find chapters mentioning the required infrastructure for e-learning models and processes, organizational practices, suggestions, implementation of methods for assessing results, and case studies focused on pedagogical aspects that can be applied generically in different environments. The second part is related to tools that can be adopted by users such as graphical tools for engineering, mobile phone networks, and techniques to build robots, among others. Moreover, part two includes some chapters dedicated specifically to e-learning areas like engineering and architecture.",isbn:null,printIsbn:"978-953-51-0053-9",pdfIsbn:"978-953-51-5655-0",doi:"10.5772/2466",price:119,priceEur:129,priceUsd:155,slug:"e-learning-organizational-infrastructure-and-tools-for-specific-areas",numberOfPages:196,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"6800611ad5f36c76151e3b01e451ee3d",bookSignature:"Elvis Pontes, Anderson Silva, Adilson Guelfi and Sergio Takeo Kofuji",publishedDate:"February 17th 2012",coverURL:"https://cdn.intechopen.com/books/images_new/2057.jpg",numberOfDownloads:29030,numberOfWosCitations:17,numberOfCrossrefCitations:21,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:29,numberOfDimensionsCitationsByBook:1,hasAltmetrics:0,numberOfTotalCitations:67,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 1st 2011",dateEndSecondStepPublish:"March 29th 2011",dateEndThirdStepPublish:"August 3rd 2011",dateEndFourthStepPublish:"September 2nd 2011",dateEndFifthStepPublish:"December 31st 2011",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"95914",title:"Prof.",name:"Adilson",middleName:"Eduardo",surname:"Guelfi",slug:"adilson-guelfi",fullName:"Adilson Guelfi",profilePictureURL:"https://mts.intechopen.com/storage/users/95914/images/3127_n.jpg",biography:"Dr. Adilson Guelfi holds PhD in Electric Engineering from the University of São Paulo. He is professor and researcher at the Institute of Technological Research of São Paulo, technical manager of the first Brazilian laboratory for testing and verifying the compatibility of systems, devices and equipments from the Brazilian Public Key Infrastructure standards.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Sao Paulo",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"120829",title:"Dr.",name:"Elvis",middleName:null,surname:"Pontes",slug:"elvis-pontes",fullName:"Elvis Pontes",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:"Elvis Pontes is professor at the University Estácio de Sá, at the Universidade Paulista, and\nat SENAC. He applied for Ph.D. at the University of São Paulo, holds MSc from the Institute\nof Technological Research of São Paulo; MBA from the Institute of Energy and Nuclear\nResearches; BSc from the Technological Institute of Osasco",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:{id:"51860",title:"Dr.",name:"Sergio",middleName:null,surname:"Kofuji",slug:"sergio-kofuji",fullName:"Sergio Kofuji",profilePictureURL:"https://mts.intechopen.com/storage/users/51860/images/4851_n.jpg",biography:"Sérgio Takeo Kofuji holds Bachelor Degree in Physics from the University of São Paulo (1985), Masters in Electrical Engineering from the University of São Paulo (1988) and Ph.D. in Electrical Engineering from the University of São Paulo (1995). He is currently Professor RiDP Polytechnic School of the University of São Paulo.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Sao Paulo",institutionURL:null,country:{name:"Brazil"}}},coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"577",title:"Educational Technology",slug:"information-and-knowledge-engineering-educational-technology"}],chapters:[{id:"28695",title:"Factors that Influence Academic Teacher's Acceptance of E-Learning Technology in Blended Learning Environment",doi:"10.5772/28682",slug:"factors-that-influence-academic-teacher-s-acceptance-of-e-learning-technology-in-blended-learning-en",totalDownloads:3140,totalCrossrefCites:19,totalDimensionsCites:24,hasAltmetrics:0,abstract:null,signatures:"Snježana Babić",downloadPdfUrl:"/chapter/pdf-download/28695",previewPdfUrl:"/chapter/pdf-preview/28695",authors:[{id:"74969",title:"BSc.",name:"Snježana",surname:"Babić",slug:"snjezana-babic",fullName:"Snježana Babić"}],corrections:null},{id:"28696",title:"Towards Economical E-Learning Educational Environments for Physically Challenged Students",doi:"10.5772/28750",slug:"towards-economical-e-learning-educational-environments-for-physically-challenged-students",totalDownloads:2111,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Amir Zeid, Sarah S. Sakit, Noor A. Al-AbdulRazzaq, Mariam M. Al-Tattan, Fatima S. Sakit, Abrar Amin, Mariam Al-Najdi and Aisha Al-Rowaished",downloadPdfUrl:"/chapter/pdf-download/28696",previewPdfUrl:"/chapter/pdf-preview/28696",authors:[{id:"75220",title:"Prof.",name:"Amir",surname:"Zeid",slug:"amir-zeid",fullName:"Amir Zeid"}],corrections:null},{id:"28697",title:"Advanced Pedagogical Approaches at Slovak Universities",doi:"10.5772/31298",slug:"advanced-pedagogical-approaches-at-slovak-universities",totalDownloads:1465,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Pavol Molnár and Ildikó Némethová",downloadPdfUrl:"/chapter/pdf-download/28697",previewPdfUrl:"/chapter/pdf-preview/28697",authors:[{id:"86488",title:"Prof.",name:"Pavol",surname:"Molnar",slug:"pavol-molnar",fullName:"Pavol Molnar"},{id:"128380",title:"Dr.",name:"Ildikó",surname:"Némethová",slug:"ildiko-nemethova",fullName:"Ildikó Némethová"}],corrections:null},{id:"28698",title:"Digital Faces on the Cloud",doi:"10.5772/27786",slug:"digital-faces-on-the-cloud",totalDownloads:2724,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"S. L. Jones",downloadPdfUrl:"/chapter/pdf-download/28698",previewPdfUrl:"/chapter/pdf-preview/28698",authors:[{id:"71531",title:"Dr.",name:"Samia",surname:"Jones",slug:"samia-jones",fullName:"Samia Jones"}],corrections:null},{id:"28699",title:"Lego Based Computer Communication for Business and Learning",doi:"10.5772/29712",slug:"lego-based-computer-communication-for-business-learning",totalDownloads:3058,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Rapelang Marumo",downloadPdfUrl:"/chapter/pdf-download/28699",previewPdfUrl:"/chapter/pdf-preview/28699",authors:[{id:"6380",title:"Dr.",name:"Rapelang",surname:"Marumo",slug:"rapelang-marumo",fullName:"Rapelang Marumo"}],corrections:null},{id:"28700",title:"Multimodal Intelligent Tutoring Systems",doi:"10.5772/29041",slug:"multimodal-intelligent-tutoring-systems",totalDownloads:1987,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Xia Mao and Zheng Li",downloadPdfUrl:"/chapter/pdf-download/28700",previewPdfUrl:"/chapter/pdf-preview/28700",authors:[{id:"76323",title:"Prof.",name:"Xia",surname:"Mao",slug:"xia-mao",fullName:"Xia Mao"},{id:"76380",title:"Dr.",name:"Zheng",surname:"Li",slug:"zheng-li",fullName:"Zheng Li"}],corrections:null},{id:"28701",title:"Using the Smith Chart in an E-Learning Approach",doi:"10.5772/29714",slug:"using-the-smith-chart-in-an-e-learning-approach",totalDownloads:7481,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"José R. Pereira and Pedro Pinho",downloadPdfUrl:"/chapter/pdf-download/28701",previewPdfUrl:"/chapter/pdf-preview/28701",authors:[{id:"79066",title:"Prof.",name:"Jose",surname:"Pereira",slug:"jose-pereira",fullName:"Jose Pereira"},{id:"122497",title:null,name:"Pedro",surname:"Pinho",slug:"pedro-pinho",fullName:"Pedro Pinho"}],corrections:null},{id:"28702",title:"Intelligent Tutoring System with Associative Cellular Neural Network",doi:"10.5772/28731",slug:"intelligent-tutoring-system-with-associative-cellular-neural-network",totalDownloads:1424,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Michihiro Namba",downloadPdfUrl:"/chapter/pdf-download/28702",previewPdfUrl:"/chapter/pdf-preview/28702",authors:[{id:"75152",title:"Dr.",name:"Michihiro",surname:"Namba",slug:"michihiro-namba",fullName:"Michihiro Namba"}],corrections:null},{id:"28703",title:"Proposing Two Algorithms to Acquire Learning Knowledge in Problem-Based Learning Environment",doi:"10.5772/29074",slug:"proposing-two-algorithms-to-acquire-learning-knowledge-in-problem-based-learning-environment",totalDownloads:1386,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Akcell Chiang",downloadPdfUrl:"/chapter/pdf-download/28703",previewPdfUrl:"/chapter/pdf-preview/28703",authors:[{id:"76427",title:"Dr.",name:"Akcell",surname:"Chiang",slug:"akcell-chiang",fullName:"Akcell Chiang"}],corrections:null},{id:"28704",title:"E-Learning in Architecture: Professional and Lifelong Learning Prospects",doi:"10.5772/30237",slug:"e-learning-in-architecture-professional-and-lifelong-learning-prospects",totalDownloads:4256,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:null,signatures:"Matevz Juvancic, Michael Mullins and Tadeja Zupancic",downloadPdfUrl:"/chapter/pdf-download/28704",previewPdfUrl:"/chapter/pdf-preview/28704",authors:[{id:"81550",title:"Dr.",name:"Matevz",surname:"Juvancic",slug:"matevz-juvancic",fullName:"Matevz Juvancic"},{id:"86547",title:"Dr.",name:"Michael",surname:"Mullins",slug:"michael-mullins",fullName:"Michael Mullins"},{id:"86548",title:"Dr.",name:"Tadeja",surname:"Zupancic",slug:"tadeja-zupancic",fullName:"Tadeja Zupancic"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"3651",title:"E-learning",subtitle:"Experiences and Future",isOpenForSubmission:!1,hash:null,slug:"e-learning-experiences-and-future",bookSignature:"Safeeullah Soomro",coverURL:"https://cdn.intechopen.com/books/images_new/3651.jpg",editedByType:"Edited by",editors:[{id:"951",title:"Dr.",name:"Safeeullah",surname:"Soomro",slug:"safeeullah-soomro",fullName:"Safeeullah Soomro"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"603",title:"Methodologies, Tools and New Developments for E-Learning",subtitle:null,isOpenForSubmission:!1,hash:"d264034a8e51ed0f264b4c935b115c81",slug:"methodologies-tools-and-new-developments-for-e-learning",bookSignature:"Elvis Pontes, Anderson Silva, Adilson Guelfi and Sérgio Takeo Kofuji",coverURL:"https://cdn.intechopen.com/books/images_new/603.jpg",editedByType:"Edited by",editors:[{id:"51858",title:"MSc",name:"Elvis",surname:"Pontes",slug:"elvis-pontes",fullName:"Elvis Pontes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3702",title:"Advances in Learning Processes",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"advances-in-learning-processes",bookSignature:"Mary Beth Rosson",coverURL:"https://cdn.intechopen.com/books/images_new/3702.jpg",editedByType:"Edited by",editors:[{id:"3280",title:"Dr.",name:"Mary Beth",surname:"Rosson",slug:"mary-beth-rosson",fullName:"Mary Beth Rosson"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4792",title:"E-Learning",subtitle:"Instructional Design, Organizational Strategy and Management",isOpenForSubmission:!1,hash:"09c4d63ffc09c72a13ab15b442a9c2b6",slug:"e-learning-instructional-design-organizational-strategy-and-management",bookSignature:"Boyka Gradinarova",coverURL:"https://cdn.intechopen.com/books/images_new/4792.jpg",editedByType:"Edited by",editors:[{id:"78424",title:"Dr.",name:"Boyka",surname:"Gradinarova",slug:"boyka-gradinarova",fullName:"Boyka Gradinarova"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3613",title:"Advanced Learning",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"advanced-learning",bookSignature:"Raquel Hijon-Neira",coverURL:"https://cdn.intechopen.com/books/images_new/3613.jpg",editedByType:"Edited by",editors:[{id:"1267",title:"Assistant Professor",name:"Raquel",surname:"Hijon-Neira",slug:"raquel-hijon-neira",fullName:"Raquel Hijon-Neira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2131",title:"eLearning",subtitle:"Theories, Design, Software and Applications",isOpenForSubmission:!1,hash:"3908775b3500496d9370ea1dd2aa97cb",slug:"elearning-theories-design-software-and-applications",bookSignature:"Patrizia Ghislandi",coverURL:"https://cdn.intechopen.com/books/images_new/2131.jpg",editedByType:"Edited by",editors:[{id:"82445",title:"Prof.",name:"Patrizia",surname:"Ghislandi",slug:"patrizia-ghislandi",fullName:"Patrizia Ghislandi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2059",title:"E-Learning",subtitle:"Engineering, On-Job Training and Interactive Teaching",isOpenForSubmission:!1,hash:"b674f8552bb902d54b4052dc1f8a7329",slug:"e-learning-engineering-on-job-training-and-interactive-teaching",bookSignature:"Anderson Silva, Elvis Pontes, Adilson Guelfi and Sergio Takeo Kofuji",coverURL:"https://cdn.intechopen.com/books/images_new/2059.jpg",editedByType:"Edited by",editors:[{id:"51860",title:"Dr.",name:"Sergio",surname:"Kofuji",slug:"sergio-kofuji",fullName:"Sergio Kofuji"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"76",title:"Digital Libraries",subtitle:"Methods and Applications",isOpenForSubmission:!1,hash:"683699486ceb61d26610104f47184608",slug:"digital-libraries-methods-and-applications",bookSignature:"Kuo Hung Huang",coverURL:"https://cdn.intechopen.com/books/images_new/76.jpg",editedByType:"Edited by",editors:[{id:"21382",title:"Dr.",name:"Kuo Hung",surname:"Huang",slug:"kuo-hung-huang",fullName:"Kuo Hung Huang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3715",title:"E-learning",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"e-learning",bookSignature:"Marina Buzzi",coverURL:"https://cdn.intechopen.com/books/images_new/3715.jpg",editedByType:"Edited by",editors:[{id:"887",title:"Dr.",name:"Marina",surname:"Buzzi",slug:"marina-buzzi",fullName:"Marina Buzzi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2058",title:"E-Learning",subtitle:"Long-Distance and Lifelong Perspectives",isOpenForSubmission:!1,hash:"e3d8574297352f8aaed548a230793d19",slug:"e-learning-long-distance-and-lifelong-perspectives",bookSignature:"Elvis Pontes, Anderson Silva, Adilson Guelfi and Sergio Takeo Kofuji",coverURL:"https://cdn.intechopen.com/books/images_new/2058.jpg",editedByType:"Edited by",editors:[{id:"51858",title:"MSc",name:"Elvis",surname:"Pontes",slug:"elvis-pontes",fullName:"Elvis Pontes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"76370",slug:"corrigendum-natural-medicinal-compounds-from-marine-fungi-towards-drug-discovery-a-review",title:"Corrigendum: Natural Medicinal Compounds from Marine Fungi towards Drug Discovery A Review",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/76370.pdf",downloadPdfUrl:"/chapter/pdf-download/76370",previewPdfUrl:"/chapter/pdf-preview/76370",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/76370",risUrl:"/chapter/ris/76370",chapter:{id:"73716",slug:"natural-medicinal-compounds-from-marine-fungi-towards-drug-discovery-a-review",signatures:"Parthiban Brindha Devi and Ridhanya Jayaseelan",dateSubmitted:"March 12th 2020",dateReviewed:"September 21st 2020",datePrePublished:"October 28th 2020",datePublished:"June 16th 2021",book:{id:"9831",title:"Drug Design",subtitle:"Novel Advances in the Omics Field and Applications",fullTitle:"Drug Design - Novel Advances in the Omics Field and Applications",slug:"drug-design-novel-advances-in-the-omics-field-and-applications",publishedDate:"June 16th 2021",bookSignature:"Arli Aditya Parikesit",coverURL:"https://cdn.intechopen.com/books/images_new/9831.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",slug:"arli-aditya-parikesit",fullName:"Arli Aditya Parikesit"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"319885",title:"Dr.",name:"Brindha",middleName:null,surname:"Devi Parthiban",fullName:"Brindha Devi Parthiban",slug:"brindha-devi-parthiban",email:"pbrindhadevi@gmail.com",position:null,institution:null},{id:"319886",title:"Ms.",name:"Thanga",middleName:null,surname:"Ridhanya",fullName:"Thanga Ridhanya",slug:"thanga-ridhanya",email:"thangaridhanya25@gmail.com",position:null,institution:null}]}},chapter:{id:"73716",slug:"natural-medicinal-compounds-from-marine-fungi-towards-drug-discovery-a-review",signatures:"Parthiban Brindha Devi and Ridhanya Jayaseelan",dateSubmitted:"March 12th 2020",dateReviewed:"September 21st 2020",datePrePublished:"October 28th 2020",datePublished:"June 16th 2021",book:{id:"9831",title:"Drug Design",subtitle:"Novel Advances in the Omics Field and Applications",fullTitle:"Drug Design - Novel Advances in the Omics Field and Applications",slug:"drug-design-novel-advances-in-the-omics-field-and-applications",publishedDate:"June 16th 2021",bookSignature:"Arli Aditya Parikesit",coverURL:"https://cdn.intechopen.com/books/images_new/9831.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",slug:"arli-aditya-parikesit",fullName:"Arli Aditya Parikesit"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"319885",title:"Dr.",name:"Brindha",middleName:null,surname:"Devi Parthiban",fullName:"Brindha Devi Parthiban",slug:"brindha-devi-parthiban",email:"pbrindhadevi@gmail.com",position:null,institution:null},{id:"319886",title:"Ms.",name:"Thanga",middleName:null,surname:"Ridhanya",fullName:"Thanga Ridhanya",slug:"thanga-ridhanya",email:"thangaridhanya25@gmail.com",position:null,institution:null}]},book:{id:"9831",title:"Drug Design",subtitle:"Novel Advances in the Omics Field and Applications",fullTitle:"Drug Design - Novel Advances in the Omics Field and Applications",slug:"drug-design-novel-advances-in-the-omics-field-and-applications",publishedDate:"June 16th 2021",bookSignature:"Arli Aditya Parikesit",coverURL:"https://cdn.intechopen.com/books/images_new/9831.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",slug:"arli-aditya-parikesit",fullName:"Arli Aditya Parikesit"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11613",leadTitle:null,title:"New Insight on Terpenes and Terpenoids",subtitle:null,reviewType:"peer-reviewed",abstract:"
\r\n\tThe book will deal with herbs and higher plants containing terpene and terpenoids. Terpene and terpenoids are responsible for giving some important medicine such as taxol and artemisinin. Terpene and terpenoids possess anti-bacterial, anti-fungal, and anti-inflammatory pharmacological activities. The objective of the book is to determine the bio-therapeutics of terpene and terpenoids. The book will review the current status of pharmacological active bio compounds under this class and will provide an update to present knowledge. The book intends to identify new bioactive compounds using the drug-repositioning methodology and computational and systematic analysis of available literature. The book will also investigate available resources among terpene and terpenoids to treat rare diseases such as neurological disorders and Charcot-Marie-Tooth disease (CMT). It will review the clinical trial status of biomolecules and tentatively give a new direction to extract terpenes and terpenoids, which can cut the cost of extraction. Finally, the biosynthesis of terpenes will be reviewed with a view to understanding their biochemical mechanism.
",isbn:null,printIsbn:null,pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,hash:"f4acd3890d8f1ef49f4b006b56d48c3b",bookSignature:"Dr. Muhammad Shahzad Aslam",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11613.jpg",keywords:"Biotherapeutics, Terpenoids, Terpene, Mechanism, Systematic Analysis, Computational, Literature, Reposition, Extraction, Biosynthesis, Biochemistry, Pharmacology",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 5th 2022",dateEndSecondStepPublish:"June 2nd 2022",dateEndThirdStepPublish:"August 1st 2022",dateEndFourthStepPublish:"October 20th 2022",dateEndFifthStepPublish:"December 19th 2022",remainingDaysToSecondStep:"13 days",secondStepPassed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"Dr. Aslam was listed as the top 1% reviewer in clinical medicine (PUBLONS), has reviewed more than 441 articles, and handled 253 articles as an academic editor in journals such as PLOS One, Medicine, and Frontiers in Clinical Diabetes and Healthcare.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"220324",title:"Dr.",name:"Muhammad Shahzad",middleName:null,surname:"Aslam",slug:"muhammad-shahzad-aslam",fullName:"Muhammad Shahzad Aslam",profilePictureURL:"https://mts.intechopen.com/storage/users/220324/images/system/220324.jpg",biography:"I had completed my degree as a Doctor of Pharmacy from Baqai Medical University, Pakistan in 2010. After, I worked in different pharmaceutical companies as a Quality control analyst. In 2011 I started my further studies for M.phil in the field of Pharmaceutical chemistry, where I got specialization in natural product chemistry and biological activities. In 2013 I started my academic job as a lecturer in Lahore Pharmacy College, Pakistan where I taught pharmaceutical chemistry, instrumentation, and organic chemistry. I had persuaded my Ph.D. in Bioprocess Engineering with specialization in Pharmaceutical Chemistry from Universiti Malaysia Perlis (UniMAP) from 2014 to 2017 and had worked on the natural products, polyherbal and their interactions in wound healing. I was awarded a scholarship by the Ministry of Higher Education, Malaysia under the Malaysian International Scholarship (MIS) to pursue my Ph.D.\nMy area of expertise is phytochemistry, pharmacognosy, green extraction technique, wound healing studies, animal modeling, novel plant extraction methods, and green solvents. I have more than 85 published articles in international peer-review referred journals and an i10-index of 15. Currently, I am working on new extraction techniques, green extraction methods, and identifying new material in the healing wound. I am currently working as Assistant Professor at Xiamen University, Malaysia.",institutionString:"Xiamen University Malaysia",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Xiamen University Malaysia",institutionURL:null,country:{name:"Malaysia"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"5",title:"Agricultural and Biological Sciences",slug:"agricultural-and-biological-sciences"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"247041",firstName:"Dolores",lastName:"Kuzelj",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/247041/images/7108_n.jpg",email:"dolores@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"6418",title:"Hyperspectral Imaging in Agriculture, Food and Environment",subtitle:null,isOpenForSubmission:!1,hash:"9005c36534a5dc065577a011aea13d4d",slug:"hyperspectral-imaging-in-agriculture-food-and-environment",bookSignature:"Alejandro Isabel Luna Maldonado, Humberto Rodríguez Fuentes and Juan Antonio Vidales Contreras",coverURL:"https://cdn.intechopen.com/books/images_new/6418.jpg",editedByType:"Edited by",editors:[{id:"105774",title:"Prof.",name:"Alejandro Isabel",surname:"Luna Maldonado",slug:"alejandro-isabel-luna-maldonado",fullName:"Alejandro Isabel Luna Maldonado"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10359",title:"Landraces",subtitle:"Traditional Variety and Natural Breed",isOpenForSubmission:!1,hash:"0600836fb2c422f7b624363d1e854f68",slug:"landraces-traditional-variety-and-natural-breed",bookSignature:"Amr Elkelish",coverURL:"https://cdn.intechopen.com/books/images_new/10359.jpg",editedByType:"Edited by",editors:[{id:"231337",title:"Dr.",name:"Amr",surname:"Elkelish",slug:"amr-elkelish",fullName:"Amr Elkelish"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"117",title:"Artificial Neural Networks",subtitle:"Methodological Advances and Biomedical Applications",isOpenForSubmission:!1,hash:null,slug:"artificial-neural-networks-methodological-advances-and-biomedical-applications",bookSignature:"Kenji Suzuki",coverURL:"https://cdn.intechopen.com/books/images_new/117.jpg",editedByType:"Edited by",editors:[{id:"3095",title:"Prof.",name:"Kenji",surname:"Suzuki",slug:"kenji-suzuki",fullName:"Kenji Suzuki"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3828",title:"Application of Nanotechnology in Drug Delivery",subtitle:null,isOpenForSubmission:!1,hash:"51a27e7adbfafcfedb6e9683f209cba4",slug:"application-of-nanotechnology-in-drug-delivery",bookSignature:"Ali Demir Sezer",coverURL:"https://cdn.intechopen.com/books/images_new/3828.jpg",editedByType:"Edited by",editors:[{id:"62389",title:"PhD.",name:"Ali Demir",surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"57360",title:"Localization of Buried Objects Using Reflected Wide-Band Underwater Acoustic Signals",doi:"10.5772/intechopen.71272",slug:"localization-of-buried-objects-using-reflected-wide-band-underwater-acoustic-signals",body:'Non-invasive detection and localization of sources is an important application area in many application domains, such as radar, sonar, seismology and communications. Thus there has been a growing interest in developing techniques for the estimation wavefronts of the direction-of-arrival (DOA) in order to detect and localize the emitting sources [1]. Support vector machine (SVM) based on electromagnetic approach [2–4] and conventional neural networks (NN) based on inverse scattering technique [5] are proposed for buried object detection. Ground penetrating radar (GPR) is used to improve the detection of weak-scattering plastic mines [6]. But electromagnetic filed inversion require more computational effort. The inversion of measured scattered acoustical waves is used to image buried objects, but it needs high frequencies and the application in a real environment is difficult [7]. Therefore, the acoustic imagery technique is not suitable because the high frequencies are strongly attenuated inside the sediment. Using a low frequency, synthetic aperture sonar (SAS) has been recently applied on partially and shallowly buried cylinders in a sandy seabed [8]. The bearing and the range estimation using correlated signals scattered from nearfield and farfield objects, in a noise environment, still a challenging problem. The MUSIC algorithm is one of the most thoroughly studied and best understood subspace based high resolution methods. It divides the observation space into two signal-subspaces: the signal subspace and the noise subspace [9]. MUSIC uses the orthogonality property between the two areas to locate sources. Different approaches exist to detect and localize buried objects but acoustic techniques will be considered in our study. Match field processing (MFP) [10] has been successfully used for localization sources in ocean acoustic. We discuss the proposed approach based on MUSIC associated with acoustic scattering model referred to MFP [10]. We take into account the water-sediment interface [11]. This means that we attempt to combine both the reflection and refraction of wave in the model [12]. From the exact solution of the acoustic scattered field [13], we have derived a new source steering vector including both the ranges and the bearings of the objects. This source steering vector is employed in objective function instead of the classical plane wave model [14, 15] which have extended the 1-D MUSIC to 2-D MUSIC. The acoustic scatter field model has been addressed in many published researches with different configurations. For example, the configurations can be single [16] or multiple objects [17], buried or partially buried objects [18] with cylindrical [16] or spherical shape [19]. All those scattering models can be used with the proposed source steering vector. In this chapter a spatial smoothing operator is proposed to estimate the coherent signal subspace [20]. Inverse power method, which allows to find an approximate eigenvector when an approximation to corresponding eigenvalue is already known, is proposed to estimate the required noise variance. In high resolution method, we use singular value decomposition (SVD) in music for obtaining the eigenvectors noise subspace. However, the main drawback is the inherent complexity and computational time load [21]. So a large number of approaches have been introduced for fast subspace tracking in order to overcome this difficulty. We propose to replace SVD by Fixed Point for computing leading eigenvectors from the spectral matrix [22, 23]. We propose another methods to accelerate MUSIC, such as projection approximation subspace tracking (PAST) [24, 25], which makes the expectation of square difference between the input vector and the projected vector minimum. With proper projection approximation, the PAST derives a recursive least squares (RLS) algorithm for tracking the signal subspace. The PAST algorithm computes an asymptotically orthogonal basis of the signal subspace. PAST with deflation (PASTD) is derived from PAST by applying the deflation technique in order to get the signal eigenvectors and eigenvalues [24, 26]. It has been shown that these subspace trackers are closely linked to the classical power iterations method, but does not guarantee the orthonormality at each iteration [27, 28]. Orthogonal PAST (OPAST) algorithm is another fast implementation of the power method which outperforms both PAST and PASTD to reduce computation time [29, 30]. The performance of the proposed algorithms are evaluated by several numerical simulations and the data has been recorded using an experimental water tank.
The remainder of the chapter is as follows: Section 2 introduces the problem formulation. Section 3 presents the scattering acoustic model of generating the received signals. Then proposed algorithm for fast localization of underwater acoustic in presence of correlated noise is presented in Section 4. Section 5 proposes the new versions of “MUSIC” without eigendecomposition. Some numerical results and Experimental tests are shown in Sections 6 and 7, respectively. Finally, Section 8 summarizes the main conclusions of this chapter.
Throughout the chapter, we use to denote: transpose operation “
Consider a transmitter that generates a plane wave with an angle
where
This matrix is estimated by
where
where
the (
the eigenvectors corresponding to the minimal eigenvalues are orthogonal to the columns of
The eigenstructure-based techniques are based on the exploitation of these properties. When the objects are far away from the array, the wavefront is assumed to be plane. Then DOA of the sources are obtained, at the frequency
where
In this section, we will present how to fill the vector of the scattering model. We consider a sedimentary covered with water and the interface is treated as a plane. An object of cylindrical or spherical shell is buried in the sediment. An incident plane wave propagating in the water reaches the interface with an angle of incidence
the incident plane wave,
the reflecting plane wave,
the transmitter plane wave diffused by the object.
Geometry configuration of buried object.
The array-interface height
Configuration of the buried object-1st sensor.
Assume a cylindrical shell long enough which is buried in the sediment with axis parallel to the interface plane. Thus the acoustic pressure wave received by the first sensor of the array
where
In this section
where
The vector
Eq. (11) or (12) give the first component of the vector. The other
These equations are employed in Eq. (5) to estimate simultaneously range and bearing of the objects.
In the following section, we summarize the proposed algorithm for fast localization of underwater acoustic sources using a wide-band transmitter to receive the signals at different frequencies, then the coherent signal subspace can be applied to decorrelate the source signals.
We use spatial smoothing to deal with narrow band correlated signal, we divide the array into
use the beamformer method to find an initial estimate of
compute the initial values of
fill the transfer matrix,
estimate the spectral matrix
estimate noise covariance matrix
calculate the spectral matrix of the signals reflected on the objects by
compute the average of the spectral matrices
calculate the spatial spectrum of the
where
Inverse Power method can be used to estimate the noise power
Let
For
Calculate
It is shown that:
In the high resolution noise subspace based methods, the DOA’s are given by the local maximum points of a cost function, for example Eq. (16) of MUSIC.
On the other hand, the additive noise is assumed to be white. But in practice, the noise is not always spatially white noise. In generally, the noise is correlated or unknown.
So in the next two sections, we will introduce the algorithms to replace SVD in MUSIC for reduce computation times and propose a new algorithm for estimating the spectral matrix of an unknown limited length spatially correlated noise.
In this section, we propose the noneigenvector versions of “MUSIC” to replace SVD to accelerate computation times.
One way to compute the
Choose
Initialize eigenvector
while
Update
Do the Gram-Schmidt orthogonalization process
Normalize v
Increment counter
Suppose that we have an estimation of the signal subspace
where
The cost function
where
We get another cost function by approximating
This function resembles the cost function used to define a recursive least squares (RLS) filter:
where
Initialization:
for t = 1,2…
end
The operator
The PAST algorithm provides a method to estimate only a basis for the dominant subspace. The exact eigenvectors (singular vector) are not calculated unless
tells that any
The first step of PASTD is to update the most dominant eigenvector by applying PAST with
Initialization:
for n = 1,2…
for i = 1,2,…,P
end
end
where estimates are made of
The OPAST algorithm is the modification of PAST. The weight matrix
where (
where
where
Using Eqs. (23) and (26), and the updating equation of
where
The traditional MUSIC method estimate the noise subspace eigenvectors by SVD. From the computational point of view, the well-known SVD method is the cyclic Jacobi’s method which requires around
The number of realizations is 1000, and the number of observations is 1000. Choosing a number of snapshots equal to 100, such as in [14, 21, 22, 29, 30], does not change the results. The mean computational load is then up to 2.5 times less with fixed point algorithm than with SVD (see Figure 3 and Table 1, N = 10 up to 30). Both versions of MUSIC provide the same results (see Figure 4, take fixed-point algorithm for example).
Computational times, SVD (red), Fixed–point (green), PAST (Black), OPAST(blue) and PASTD (pink).
10 | 15 | 20 | 25 | 30 | |
Time SVD (second) | 0.95 | 1.3 | 2.4 | 4.4 | 7.1 |
Time fixed point (second) | 0.5 | 0.6 | 1.1 | 1.8 | 2.8 |
Time PAST (second) | 0.4 | 0.5 | 0.8 | 1.4 | 2.2 |
Time PASTD (second) | 0.3 | 0.4 | 0.7 | 1.3 | 2.0 |
Time OPAST (second) | 0.5 | 0.7 | 1.3 | 2.1 | 2.9 |
Ratio SVD/fixed point | 1.9 | 2.2 | 2.2 | 2.4 | 2.5 |
Ratio SVD/PAST | 2.4 | 2.6 | 3.0 | 3.1 | 3.2 |
Ratio SVD/PASTD | 3.2 | 3.3 | 3.4 | 3.4 | 3.6 |
Ratio SVD/OPAST | 1.9 | 1.9 | 1.8 | 2.1 | 2.4 |
Computational time needed to run MUSIC for various numbers of sensors.
(a) Pseudospectrum of MUSIC obtained using fixed point, (b) pseudospectrum of MUSIC obtained using SVD.
The studied signals are recorded during an underwater acoustic experiment in order to estimate the developed method performance. The experiment is carried out in an acoustic tank under the conditions similar to those in a marine environment. The bottom of the tank is filled with sand. The experimental device is presented in Figure 5. The tank is topped by two mobile carriages. The first carriage supports a transducer issuer and the second supports a transducer receiver pilot by the computer.
Experimental setup: (a) Data acquisition system, (b) Experimental tank.
Four couples of spherical and cylindrical shells (see Figure 6) are buried between 0 and 0.05 m under the sand. The considered objects have the following characteristics, where
the 1st couple (
the 2nd couple (
the 3rd couple (
the 4th couple (
Experimental objects.
The considered objects are made of dural aluminum with density
In addition to estimate the performance of the propose method, the signal source a spatially correlated noise is emitted with
Experimental setup.
At each sensor, time-domain data corresponding only to target echoes are collected with signal to noise ratio equal to 20 dB. The typical sensor output signals recorded during one experiment is shown in Figure 8.
Example of observed signals during experiment Exp. 1.
The proposed algorithms were applied on each experimental data set. Forming the directional vector by the model of acoustic diffusion appropriate to locate the objects and the spectral matrix of the simulated data. We use the focusing operator on the signals by dividing the frequency band [150, 250] kHz in 11 frequencies and Alg. 2, Alg. 3, Alg. 4 and 5 to calculate the noise subspace, respectively. Finally we apply Eq. (16) to estimate DOA of objects and object-1st sensor distance.
As is shown in Figure 9, X axis is the object-1st sensor distance
Example of object localization with different methods: (a)-(b) SVD, (c)-(d) Fixed-point, (e)-(f) PAST, (g)-(h) PASTD and (i)-(j) OPAST.
We have done statistical study in order to a posteriori verify the quality of estimation of the proposed method. Standard Deviation (Std) is defined as follows:
where
Standard deviation versus SNR of the bearing and the range estimation.
The main target of array processing is the estimation of the parameters: DOA of objects and the objects-sensors distance. In this chapter, we have proposed a new fast localization algorithm to estimate both the ranges and the bearings of buried sources underwater acoustic in presence of correlated noise. This algorithm takes into account both the reflection and refraction of water-sediment interface. We develop fixed point algorithm in MUSIC instead of SVD to keep the small computational time load. A new focusing operator is proposed to estimate the coherent signal subspace. Some simulations have been done to test our method. We compare the computation time of MUSIC with SVD and fixed point, it shows that fixed point is faster than SVD. The proposed method performance was investigated through scaled tank tests associated with some cylindrical and spherical shells buried in an homogenous fine sand. The obtained results are promising and the
Water covers about 70 per cent of the Earth’s surface, makes up about 75 per cent of human body mass, and is the basic material that all living things need to live. The fact that water covers more than two-thirds of the Earth’s surface makes it hard to believe that it is a scarce resource and that less than 1% of the total water on this planet is readily accessible for drinking or other uses. Approximately 97% of the earth’s water is salt water contained in lakes or seas; just 3% is fresh water. However, 68 per cent of freshwater on Earth is enclosed in the Antarctic and Greenland ice caps (30%) while just 0.3 per cent is enclosed in surface waters, including lakes, rivers, reservoirs, springs and streams. Water quality can be defined by its physical, chemical, biological and esthetic characteristics (appearance and smell) as well as by its fitness for the beneficial uses it has in the past provided for human and animal drinking, for the promotion of a healthy aquatic life, for irrigation of the land and for recreation. A safe water ecosystem is when it meets the standard in term of water maintains a rich, diverse population of species and is conducive for the consumption of public health. Water is of course, the basic liquid medium for living matter; thus, it is uniquely vulnerable to contamination by living creatures, including those that cause disease to humans. Aquatic contamination occurs as a result of the introduction by humans of either direct discharges into the water body or indirect substances or/energy that may result in the degradation of the water quality of any water body that poses a danger to human health, harms living organisms and hinders aquatic activities such as fishing and polluted water quality with respect to its use. Contamination mechanisms including suspension, solution and biochemical alteration is not inherently separate and distinct from each other and all of these complex processes may only occur in water. However, growing anthropogenic activities, such as urbanization, Industries, agricultural waste, etc. and natural processes, reduce water quality and pose a danger to all modes of life. Most people live in underdeveloped countries still depend on unprotected/contaminated water sources as their primary sources of drinking water and at the same time, as their means of waste disposal, which can cause outbreaks of waterborne diseases. The discharge of industrial waste into water bodies constitutes approximately 62 per cent of the overall source of heavy metals such as lead (Pb), zinc (Zn), copper (Cu), nickel (Ni), cadmium (Cd) and chromium (Cr) [1]. It is important to write about contamination caused by heavy trace elements, since untreated waste materials discharged by industry or agriculture worldwide are very concerned about the current disposal of waste materials containing heavy metals such as mercury, cadmium, lead, copper and arsenic due to growing concentrations in many waters.
Poultry farms are one of the world’s leading sources of high-grade and palatable protein-rich food (eggs and meat) but domestic, industrial and agricultural poultry waste is regularly disposed of without treatment into water bodies, especially in most developing countries. Poultry farming is a lucrative global trade in animal husbandry that raises domesticated birds such as chickens, ducks, quails, pigeons, guinea fowl, turkeys and geese to produce meat or eggs for food originating in the agricultural period. According to the World Watch Institute, 74% of meat consumed worldwide is from poultry meat, and 68% of eggs are derived intensively from poultry, while more than 60 billion chickens are killed annually for consumption [2]. There is little doubt that the demand and therefore the production of poultry will continue to increase relative to the world population, the economy and also the increase in the production of poultry wastes. Poultry waste is used as manure in many fields, but when disposed of in a water body without treatment, it may cause significant problems for aquatic life due to the presence of heavy metals in it. Poultry waste as a mixture of different media involving feces, bedding materials, wasted feeds and feathers, represent favorable media for wide range of chemical and biological hazards include many food-borne pathogens like
Due to increased demand for livestock meats and eggs, there is also a need for increased use of trace elements (some of which are also heavy metals’) as nutritional supplements in poultry diets to boost feed quality, promote weight gain and prevent disease, resulting in increased concentration of trace elements added to poultry diets. However, poultry feeds, whether natural or locally sourced or improved by special manufacturing processes, have been reported to be affected by the content of heavy metals in the feed [4]. Many heavy metals are also added to poultry feed as supplements, including copper (Cu), manganese (Mn), iron (Fe), selenium (Se), zinc (Zn) which are important nutrients needed for various biochemical and physiological functions in species, and a lack of supply of these micronutrients results in a number of deficiency diseases or syndromes [5]. Iron and Cu are added to prevent anemia, selenium is added to prevent oxidative cell damage, and Zn and Mn are added to ensure proper egg shell deposition and feather growth [5]. Calcium (Ca2+) is added for bone formation, while in mature laying fowl the majority of dietary calcium is used for egg formation and plays a role in blood clotting and intracellular communication. Antioxidants are added to delay the deterioration of vitamins in poultry feed and tranquilizers may be used to keep flocks quiet in the house and during transport to another pen. A wide variety of antimicrobial drugs are commonly administered to poultry feed as prophylaxis and/or growth promoter and most of the oral applied antibiotics are poorly absorbed in the poultry gut, and then consequently those large amounts of antibiotics were excreted in feces and urine to the environment. Approximately 90% of the applied antibiotics might be excreted as the parent compound [6]. The most common antibiotics such as bactracin, chlortetracycline, monesin, tylosin, penicillin, chloramphenicol and virginiamycin can be applied to poultry feed to fight diseases, pests and increase the supply of certain nutrients that transferred through the food chain to humans that induce antimicrobial resistance in humans. Topical pesticides are used as a repellent against flies, lice, bugs, mice and reptiles that can harm or destroy them. WHO/FAO [7], NRC [8], EU [9, 10, 11, 12] and SON [13] set acceptable levels of metals in animals, but excessive or deficient use of these metals may lead to deformity in the body or to health problems, some of which may cause serious toxicity, which may lead to the death of the animal (Tables 1 and 2). However, pollutants from poultry waste can have detrimental environmental consequences (air, soil and water) if their waste is poorly handled or untreated prior to disposal in the aquatic setting. The disposal of waste produced by the poultry industry is a long-standing concern due to the contribution of nutrients or as a source of heavy metal contamination to our water bodies. Livestock manure may be used as fertilizer in the agricultural sector, it may also degrade the quality of the environment, especially surface and ground water, if it is not properly managed [14]. Untreated poultry waste can degrade water quality when discharged directly to surface water by runoff. The key environmental and health threats associated with animal waste are the introduction of toxins into water sources, such as nutrient limitation (nitrogen and phosphorus), organic matter, sediments, bacteria and heavy metals, which have harmful effects on the living organism and change the nature of the water. However, all mineral elements, whether considered to be necessary or potentially harmful, can have an adverse food impact on humans and animals if they are included in the diet at an overly high concentration [15]. Trace mineral bioavailability is characterized as the proportion of the component consumed that is used for biochemical or physiological purposes [16]. In order to have a high bioavailability, the mineral component must be readily absorbed and rapidly integrate by the body. Bioavailability is mainly influenced by the chemical form of the mineral or the amount in the diet, the amount in the body of the animal, the concentration of other minerals in the diet, its age and the physiological state of the animal to which it is fed. The risk lies in the accumulation of manure-borne metals, as they are not biodegradable and ultimately become phytotoxic, and the long-term use of poultry waste on the soil could lead to the accumulation of heavy/trace elements that increase the potential bioavailability and toxicity of metals in the environment. Such accumulation has the potential to limit soil function, contaminate water and cause toxicity to plants, animals and humans via the food chain. Their bioavailability is determined by physical, chemical and biological factors such as temperature, adsorption, sequestration, lipid solubility and water partition coefficients, whereas biological factors such as species characteristics, trophic interactions and biochemical/physiological adaptation also play an important role [17]. Poultry waste is more toxic than other animal waste due to the high concentration of heavy metals in poultry feed which is not directly absorbed by the body of the animal and egestion as a waste product, while the land application of poultry manure may result in the absorptions of toxicants by plants, animals and humans through absorption, ingestion, bioaccumulation or other processes.
Trace/heavy metals | FAO/WHO [7] and EU [9, 10, 11, 12] | National Research council [8] | |
---|---|---|---|
Metals requirement in total diet dry (mg/kg) | Metals requirement in normal diet (ppm) | Toxic level in total diet (ppm) | |
Cadmium | 1 mg/kg | ||
Chromium | 0.01 mg/kg | ||
Cobalt | 1 mg/kg | ||
Copper | 100 mg/kg | 6–8 ppm | 250–800 ppm |
Iron | 45–80 mg/kg | 50–80 ppm | 4,500 ppm |
Iodine | 0.3–0.4 ppm | 625 ppm | |
Lead | 1–5 mg/kg | ||
Manganese | 20–60 mg/kg | ||
Molybdenum | 3–5 ppm | 20–10 ppm | |
Mercury | 0.5 mg/kg | ||
Nickel | 0.05 mg/kg | ||
Selenium | 5–20 pm | ||
Zinc | 600 mg/kg | 40–75 ppm | 800–4,000 ppm |
Permissible limits of trace/heavy metals requirements as an additive in poultry feed.
Trace mineral | Egg Layer | Brolier | Brolier Breeder | Cockerel | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Chick Mash (0–8 Weeks) | Grower Mash (9–17 Weeks) | Layer 1 (18–45 Weeks) | Layer 2 (46–72 Weeks) | Pre-Starter (0–8 Days) | Starter (9–21 Days) | Finisher (22–42 Days) | Broiler Breeder Starter (0–8 Weeks) | Broiler Breeder Grower (9–17 Weeks) | Broiler Breeder Female 1 (18–45 Weeks) | Broiler Breeder Female 2 (46–72 Weeks) | Cockerel Starter (0–8 Weeks) | Cockerel Finisher (9 Weeks –Market) | |
Manganese (mg) | 60 | 60 | 60 | 60 | 60 | 30 | 30 | 60 | 60 | 90 | 90 | 60 | 60 |
Iron (mg) | 30 | 30 | 30 | 30 | 80 | 60 | 60 | 30 | 30 | 30 | 30 | 30 | 30 |
Copper (mg) | 6 | 6 | 6 | 6 | 5 | 4 | 4 | 6 | 6 | 12 | 12 | 6 | 6 |
Zinc (mg) | 60 | 60 | 60 | 60 | 40 | 35 | 35 | 60 | 60 | 100 | 100 | 60 | 60 |
Iodine (mg) | 0.5 | 0.5 | 0.5 | 0.5 | 0.4 | 0.4 | 0.4 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
Selenium (mg) | 0.3 | 0.3 | 0.3 | 0.3 | 0.2 | 0.1 | 0.1 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 |
The word heavy/or trace metals is sometimes used loosely, as they contain a number of metals, some of which are not heavy and some of which are not metals. Heavy metals are a wide class of inorganic chemicals that are harmful to both human and environmental health. Heavy metals are commonly referred to as metals with a minimum density of more than 5 gm/cm3 and adversely impacting the environment and living organisms. Heavy metals include all metals and metalloids except alkali and alkaline earth elements. Some heavy metals are necessary for enzymatic activity and can inhibit enzyme activity when natural concentrations are exceeded. Although some heavy metals are needed as micronutrients, they may be toxic at higher levels than their requirements. In addition, elements such as C, H, O, N, P, S, K, Ca and Mg are often required by majority of species in very small amounts. These elements are called trace elements, such as Fe, Mn, Cu, Co and Mo, and are usually considered to be necessary for most organisms, although V, B and Zn are confirmed to be essential in at least some cases. Most of these trace elements function in an enzyme or in an active group in an enzyme. Since heavy metals cannot be degraded, they are deposited, assimilated or incorporated into water, soil and marine organisms, causing heavy metal contamination in water bodies. Essentials include iron, copper, zinc, cobalt, manganese, chromium, molybdenum, selenium, tin, nickel and vanadium. The deficiency or elevation of these elements can affect the body’s normal physiological activities and biochemical processes, resulting in abnormal cell metabolism, development, reproductive disorder and severe oxidative. Non-essential metals are lead, cadmium and mercury. Cobalt, copper, chromium, iron, manganese, nickel, molybdenum, selenium, tin and zinc, sometimes known as trace metals. As a result, the majority of heavy metals, whether necessary or not, are potentially harmful to all living organisms, depends on many factors, such as dosage intake, species chemical composition, age of organisms, gender, genetic make-up and nutritional status of exposed individuals [17]. They have various effects on species depending on dosage exposure and durations of consumption: acute poisoning occurs when exposed to high doses over a short period of time, and chronic poisoning or bioaccumulation occurs when exposed to low doses over a long period of time. ‘Toxic metals, including ‘heavy metals, ‘are individual metals and metal products that have harmful human health effects either by direct or indirect exposure. Trace minerals or heavy metals used in animal feed are often expressed either as parts per million (ppm) or as milligrams per kilogram (mg/kg) of dietary dry matter. In very small quantities, many of these metals are required to sustain life and become toxic in large quantities. They can build ups in biological systems and become a major health hazard” [18]. The term heavy metal refers to any metallic chemical elements that have a comparatively high densities compared to water and are found in traces in different matrices. Their heaviness and toxicity are interrelated as heavy metals are capable of causing toxic or toxic at low concentrations and, if present in animal feed, pose significant health hazards to poultry meat consumers due to biomagnification effects in the body of the animal [19, 20, 21, 22]. Heavy metals are normal components of the earth’s crust that are not depleted or damaged in the atmosphere and are harmful to human health because they appear to be bioaccumulate for a long period of time, e.g. mercury (Hg), cadmium (Cd), arsenic (As), chromium (Cr), thallium (Tl) and lead (Pb). Bioaccumulation refers to the rise in the concentration of the chemical in the body of the organism over time as opposed to the chemical concentration in the atmospheres. Accumulation of compounds in the organism at any time taken up is processed faster than broken down (metabolized) or excreted. Toxicity could result from any heavy metal, but ten (10) of them are among the top twenty hazardous substances considered to be toxic by several agencies due to their health implications, including arsenic, cadmium, chromium, cobalt, copper, iron, lead, manganese, mercury and platinum [17, 23]. In recent decades, the levels of these metals have risen in our environments as a result of human inputs and activities [24, 25, 26]. There are 35 different metals that are of considerable concern to human health due to residential or industrial exposure. They are widely present in the environment and animal diet as a food supplement and are needed in small quantities to maintain good health, but in larger amounts they become harmful or unsafe due to their accumulation in the animal’s body over time and may cause serious illness or death. Considering the great variety of heavy metals in the environment, their concentration in various feed chains, it is difficult to achieve a lower level of toxicity than the detection limit for all elements in all products [27]. The European Union, the United States, Asia and other countries are aware of all these problems and as a result numerous laws have been implemented to regulate all heavy metal contamination, reduce the risk of human exposure in the food chain and develop detection methods to control these pollutants in the food chain [28].
Arsenic is used in poultry production for growth promotion and for controlling intestinal parasites in which they are fed with arsenic compound called roxarsone (3-nitro-4-hydroxyphenylarsonic acid) while three-quarters of arsenic in feed will be excreted out as poultry waste into environment [29]. Arsenic is a natural soil constituents with concentrations of up to 500 mg/kg. In its essential form, arsenic is insoluble in water, but many of the arsenates are highly soluble. Much if not all-natural water contains compounds of arsenic. Arsenic is the most common cause of acute heavy metal poisoning in adults and is number 1 in the Top 20 List of ATSDR. Arsenic can also be present in water sources worldwide, contributing to contamination of shellfish, cod and haddock. The target organs are the blood, kidney, central nervous, digestive and skin systems [30]. Arsenic is noted for its human toxicity when ingestion of as little as 100 mg typically results in serious poisoning and 130 mg has been shown to be fatal [31]. Several incidents have shown that arsenic in water can be carcinogenic, that skin and probably liver cancers are due to arsenic in drinking water [32, 33].
Lead is number 2 on the “Top 20 List.” for the ATSDR. Lead accounts for most cases of pediatric heavy metal poisoning [30]. Goal organs are bone, brain, blood, kidney, and thyroid gland [23, 34]. Some natural water contains as much as 0.8 mg/l of lead in solution [35]. These concentrations are also found in mountain streams that flow through limestone and galena. It causes acute and chronic toxicity and causes a wide variety of physiological, biochemical and behavioral dysfunctions in humans, animals and aquatic species. Addition of lead to the diet results in a dose-related rise in the concentration of Pb in different organs in the body of animals such as the kidney, blood stream, liver and tibia. It induces oxidative stress that suppresses growth efficiency and decreases feed intake and body weight loss.
The number 3 of ATSDR’s “Top 20 List” is mercury and naturally generated in the environment by degassing the earth’s crust, by volcanic emissions [36]. It is available in three forms: elemental mercury, organic and inorganic mercury. Atmospheric mercury is spread across the globe by winds and returns to the planet in runoff, collecting in marine food chains and fish in lakes [37]. Many researchers believe that dental amalgam could be due to a source of mercury toxicity. Mercurochrome and merthiolate are still in use in drugs, while algaecides are the main possible sources of mercury by inhalation. The organic form is readily absorbed in the gastrointestinal tract (90–100%); Less but nevertheless large amounts of inorganic mercury are absorbed in gastrointestinal tract (7–15%) and the target organs are majorly brain and kidneys [30].
Cadmium is a derivative from the smelting or mining activities of lead and zinc in environment and it occupied 7 position on ATSDR’s “Top 20 list.” It also used in nickel cadmium batteries production, PVC plastics, and paint pigments industries. It can also find in Cigarettes, as well as in soil as a result of insecticides, fungicides, sludge, and other commercial fertilizers that contain cadmium compound in agriculture or in reservoirs that contain shellfish. Other sources of cadmium contamination are from dental alloys, electroplating, engine oil and automobile exhaust. Inhalation of cadmium accounts for 15–50 per cent of assimilate into the respiratory tracts; 2–7 per cent of the ingested cadmium is absorbed into the gastrointestinal system while main target organs are the liver, placenta, kidneys, lungs, brain and bones [30]. Cadmium is moderately harmful to all species and is a cumulative toxin in mammals. In low concentrations, the use of trivalent chromium as an additive in animal diets may induce rapid growth for the animal in order to improve the quality of the meat produced, but often poultry owners may add trivalent chromium in excesses for rapid growth of their animals in order to obtain further value, which may have adverse effects on animals such as those injured and poisonous to the animal. It appears to be concentrated in the kidneys, liver, pancreas and thyroid of humans and other mammals. Humans can be exposed to this metal mainly through inhalation and ingestion, and can suffer from acute and chronic intoxication. Kar and Patra [38] reported that the Cd concentration sometimes increases in feeds, fodders, water bodies, and tissues of livestock which causes metabolic, structural, and functional changes of different organs of all animals. In poultry birds, bioaccumulation of Cd occurs in several organs mainly in the liver, kidney, lung, and reproductive organs due to its continuous exposure. Intake of Cd reduces growth and egg laying performance and feed conversion efficiency in poultry. Chronic exposure of Cd at low doses can also alter the microscopic structures of tissues, particularly in the liver, kidney, brain, pancreas, intestine, and reproductive organs due to increased contents of Cd in these tissues. Continuous Cd exposure causes increased oxidative stresses at cellular levels due to over-production of reactive oxygen species, exhausting antioxidant defense mechanisms. This leads to disruption of biologically relevant molecules, particularly nucleic acid, protein and lipid, and subsequently apoptosis, cell damage, and necrotic cell death. The histopatholocal changes in the liver, kidneys, and other organs are adversely reflected in hemogram and serum biochemical and enzyme activities.
Iron does not appear on the ATSDR’s “Top 20 List, “ but it is a heavy metal of concerns, particularly because ingesting dietary iron supplements may acutely poison young children. Uses of Fe as additives in feed formation have many disadvantages such as low bioavailability, high hydroscopicity and oxidative, high excretion and so on [39]. Iron deficiency is still a major problem in several segments of the livestock production causes microcytic, hypochromic anemia in chickens. Iron also plays a role in other enzymes involved in oxygen transport and the oxidative process, including catalase, peroxidases, flavoprotein enzymes and cytochromes. Approximately two-thirds of body iron is found in hemoglobin (red blood cells and myoglobin in the muscles), while 20% is present in labile forms in the liver, spleen and other tissues, with the remainder not available in tissues such as myosin and actmysin and in metalloenzymes. The iron in hemoglobin is essential for the proper function of every organ and tissue of the body. The iron requirement of chicks fed casein, dextrose, and isolated soybean protein concentrate-based diet was studied by Aoyagi and Baker [40]. Ingestion accounts for most of the toxic effects of iron because iron is absorbed rapidly in the gastrointestinal tract and other target organs are the liver, cardiovascular system, and kidneys [30].
Zinc plays an important role in biological process in animal including immune function, growth, development and reproduction. It is component of many enzymes contributing in the energy metabolism, protein synthesis and degradation biosynthesis of nuclei acids, carbon dioxide, transport and many more. Its performance major role as an antioxidant in diet, growth and development, production, immunity and stress related issues. It is important in animal diets formation because it influences economic profitability of egg modifying. Zinc has a beneficial impacts on the growth and reproduction of livestock. Due to the low zinc and copper contents of some home-grown feeds compared to guidelines and varying bioavailability, supplementation of these metals is essential for most livestock species and is usually added as mineral supplements to dairy rations [7, 9, 10]. Zinc deficiency causes growth retardation and irregular production of feathers in poultry animals. Feather spattering occurs towards the end of the feather while severity of the spattering ranges from no feathers on the wings and tail to minor defects in the growth of some of the barbels and the hog joint may be widened. Zinc deficiency can causes the long bones of the legs and wings to be shortened and thickened. Other signs include loss of appetite, decreased feed use quality, and death in extreme cases. Zinc deficiencies in the breeding diet decreases egg production and hatchability. Embryos developed in zinc-deficient eggs display a wide range of skeletal anomalies in the head, limbs and vertebrae. The hatched chicks will also not stand, eat or drink [41]. Proper zinc supplementation has been shown to be effective in reducing the early mortality of poultry animals and zinc supplementation is typically applied to animal diets in the form of zinc oxide or zinc sulfate. Latest comparisons of bioavailability in chicks suggest that feed grade zinc oxide has just 44–78 per cent of zinc sulfate availability when added to refined or functional diets [42, 43, 44]. Zinc toxicities can cause health problems, and prolonged consumption can also lead to negative side effects such as nausea and vomiting, loss of appetite, diarrhea, abdominal cramping and immunity. The risk associated with zinc deficiency could cause gastrointestinal diseases such as Crohn’s disease, decreased immunity, thinning of hair, decreased appetite, weight loss, skeletal malformations, poor bone mineralization, immunological dysfunction, mood disorders, dry skin, fertility problems and impaired wound healing, inadequate dietary intake, poor absorption, genetic mutations. Symptoms of extreme zinc deficiency include impaired growth and development, delayed sexual maturity, chronic diarrhea, impaired wound healing and behavioral problems [45, 46].
Nickel is an essential element required in low amount for animal growth and it is required for activities of vitamin B12 and biotin during metabolism of odd-chain fatty acids in animals [47]. Depending on the dose and length of exposure, as an immunotoxic and carcinogen agent, nickel can cause several health problems such as contact dermatitis, cardiovascular disease, asthma, lung fibrosis, and respiratory tract cancer [48, 49]. However, the exposure of human beings mainly concerns oral ingestion through water and food as nickel may be a contaminant in drinking water and/or food [50]. Although the molecular mechanisms of nickel-induced neurotoxicity are not yet clear, oxidative stress and mitochondrial dysfunction have a significant role to play. Mitochondrial nickel-induced damage can occur due to impaired mitochondrial membrane potential, decreased mitochondrial ATP concentration and degradation of mitochondrial DNA [51]. Nickel, high concentrations of which can affect human health badly, can accumulate on plants, animals, and soil.
Based on the study by Eloma et al. [56], which analyzed six potentially toxic elements (PTEs) from poultry feeds such as Cd, Cr, Cu, Pb, Mn, Ni and Zn, four feed forms (starter, grower, finisher and layer) from four producers coded A, B, C and D were sold in Ebony State, Nigeria. The mean concentrations of metals recorded from poultry feeds were as following: Chromium (11.9–7.90 mg/kg); Copper (5.10–7.91 mg/kg); Cadmium (0.49–0.76 mg/kg); Lead (7.17–9.47 mg/kg); Manganese (26.9–34.9 mg/kg); Nickel (3.80–6.50 mg/kg) and Zinc (27.8–38.4 mg/kg). The result of these findings was compared with European Union standard of PTEs maximum acceptable concentration in feed while Pb and Ni concentrations were above the maximum acceptable limits that is risk to human health. Thus, there is a need for continuous monitoring of feed compositions. Lead and Ni exceeded permissible limits by European Union in feed as stipulated, but the perilous elements such as Cr, Cu and Zn were also high in feed. There is however a need for continuous monitoring of feed compositions and also for the introduction of practices that will not introduce PTEs into the system. It also recommended that a proximate study be carried-out on poultry feeds to determine its moisture content, ash content, crude fiber, lipid, crude protein, carbohydrate and metabolizable energy [57, 58, 59].
Kabir and Bhuyan [60] were conducted to determine the heavy metal content of hens (
Korish and Attia [61] conducted research on heavy metal content in feed, litter, meat, meat products, liver and table eggs of chickens. Concentrations of heavy metals were examined in chicken meat, meat products, feed, litter, as well as laying hen eggs to track the regularity of this metals in the market products and their protection for human consumption as recommended daily allowance (RDA). Samples were collected from most popular poultry products in Saudi Arabia. A total of 45 samples from frozen broiler meat, fresh beef, liver, frankfurter and burger were collected from the same brand. However, 60 table eggs were collected from four different commercial brands while the edible parts of egg were analyzed to determine the levels of mineral elements present in it. In addition, 30 samples from different feed and litter were collected from the starter feed, grower feed, diets of layer broilers and laying hens. The findings showed that there were extensive amounts of most trace or heavy metals in the various meat sources while liver had the highest concentration of all elements examined, except for Co, Cr and Ni. The highest amount of Chromium concentration was recorded in fresh meat, followed by frozen meat. Trace or heavy metals such as Mn, Co, Ni and Pb were not detected in frozen or fresh meat. The chicken burger and the frankfurter samples have similar concentrations of trace/heavy metal except for Zn and Mn which had higher concentrations was observed in frankfurter compared to burger sample. There were significant differences between zinc concentration of the different sources of eggs. Fe was significantly higher in beef meat compared to poultry meat but the opposite trend for Zn was observed. All heavy metals concentration in were higher in liver than the eggs, except for Chromium while the burger had higher concentrations of Cu and Co. finally, it concluded that Cd, Pb, As and Se are not detected in chicken meat and eggs produced which indicate that no human hazards from these toxic elements. However, the liver had the highest concentration of all heavy metals examined, except for Cr, and the intake of Pb and Cd from the broiler liver was higher than the RDA for adults. Burgers and frankfurters, showed higher concentrations of Pb, Cd and Ni than chicken meat and table eggs, implying a potential human health danger. Therefore, in order to enhance the quality of poultry products for human consumption, adequate legislation is required to regulate the quality of poultry products, as well as feed/food and chicken litter. In addition, critical measurements should be used for the detoxification of heavy metals from waste. The relationship between the minerals in poultry production and the diet of poultry and poultry litter remains fertile for further study.
Study of Dahri et al. [62] on the investigation of concentrations of heavy metals; lead and chromium in chicken feed collected from commercial poultry feed markets and local poultry farms in Hyderabad Sindh. A total of eight samples of poultry feeds, four of which were commercial feed samples and four of which were local feed samples collected in polyethylene bags. The samples were analyzed using the Aurora Al1200 Atomic Absorption Spectrophotometer (AAS) for heavy metals; lead (Pb) and chromium (Cr). Relatively higher concentrations of lead (Pb) have been found in commercial feed samples. Data obtained from the present study for lead and chromium beyond the allowable limit, i.e., 0.05 and 0.1 ppm as recommended by WHO/FAO. Lead (Pb) and chromium (Cr) metals are important for the growth of poultry, but they may become toxic if the concentrations exceed the allowable limits. Excessive quantities of metals taken by animals make their way to the human body, which is extremely dangerous to human health. Heavy metal contamination is prevalent in the Hyderabad district and thus in the present report, the amount of poultry feed is alarming. The nutritional values of the feed are therefore calculated from the concentrations of lead and chromium above the allowable level in the feed content.
Aquatic ecosystems are highly complex, diverse and subject to a variety of internal and external relationships that are subject to change over time. Public health issues are among the pollutants that the concentration of heavy metals in marine environments enters humans through food chains. Heavy metal contamination may occur from many causes, but most generally results from metal purification, e.g., copper smelting and nuclear fuel preparation. Following the introduction of heavy metal pollutants into the flow, whether from natural or anthropogenic sources, they divide between aqueous (pore water and overlying water) and solid phases (sediment, suspended particulate matter and biota). Anthropogenic metals can persistently persist inside water bodies, or these elements are absorbed by silt, likely absorbed by animals, and accumulate in the food chain, beginning easily with plankton, such as filtering zooplankton, benthos, or fish, and eventually transferred to humans. Unlike organic contaminants that lose biodegradation toxicity, heavy metals cannot be degraded/decayed and thus pose a different form of remediation challenge. Heavy metals such as lead, mercury, iron, cadmium, aluminum and magnesium are found in water supplies. If these metals are found in the sediment, they enter the food chain through plants and aquatic animals.
The effects of heavy metals on marine species vary from a small drop in the rate of growth to death. Pollutants entering inshore waters and estuaries cause severe problems, causing significant harm to the life and activities of living aquatic species and also to the mass mortality of organisms. The gradual and irreversible accumulation of these metals in the various organs of the creatures of life contributes to long-term metal-related diseases due to their toxicity, endangering aquatic biota and other organisms [36]. Heavy metal pollution may have detrimental effects on the ecological balance of the recipient ecosystem and the diversity of marine species [63, 64, 65]. Among the animal species, fish are those that cannot avoid the adverse effects of these contaminants [66, 67, 68]. These metals are responsible not only for the deterioration of the water quality of the body, but also for the death of a variety of aquatic species [69]. The disposal of these wastes adversely affects water bodies, changes their chemical composition and causes harm to both humans and aquatic organisms [70, 71, 72]. These heavy metals (arsenic, cadmium, chromium, cobalt, copper, iron, lead, manganese, mercury and platinum) become toxic by accumulations of flora and fauna in the body tissues and then move through the food chain from fish to humans [73, 74]. Cadmium causes certain problems similar to those caused by mercury, which are much more harmful than mercury; Daphina, Scenedesmus and
Mercury emission experiments in aquatic environments indicate that recovery from pollution will take place within a limited period of time following the cessation of pollution input [81]. The embryonic and larval stages of marine organisms are typically the most susceptible periods of the life cycle for heavy metals and other toxicants. Copper accelerated the mortality of
The great concern lies in the excessive accumulation of macro-minerals (Ca, Si, Fe), trace elements (Cu, Mn, Zn, Se), heavy metals (Pb, Hg, Cd), medicinal drugs (antibiotics, coccidiostatics, sulfa drugs, etc.), anti-metabolites, insecticides, herbicides, wood preservatives, mycotoxins and hormones, harmful organisms transmittable other non-nutritional excretory via wastes to man. Poultry waste contains considerable amounts of nutrients (nitrogen and phosphorus) and other excreted substances such as hormones, antibiotics, harmful pathogens and heavy metals. Leaching and runoff of these substances has the potential to contamination both the surface water and/or nearby groundwater (Steinfeld et al., in [82]). Thus, increased outputs of phosphorus and nitrate to fresh water which can caused severe water quality problems like accelerate eutrophication in surface waters due to high inputs of organic substances and nutrients through runoffs which can result into accumulation pollution nutrient-sensitive ecosystems resulting in biodiversity losses such as fish kills due to hypoxia/anoxia and high levels of ammonia, harmful toxic algal blooms, decreases in water clarity, widespread anoxia, declines in submerged aquatic vegetation, shifts in pH, and depletion of oxygen. A drop in the level of dissolved oxygen in surface water has deleterious effects on fish populations [83, 84]. Furthermore, eutrophication can spur the growth of toxic microorganisms, such as