\r\n\tOver the years, the concept of maintenance became more comprehensive, reducing fault occurrence and increasing industrial system availability. Besides, reliability, safety, and criticality requirements were associated with the system or equipment under analysis. Maintenance strategies or schemes can be classified as corrective (run-to-break), preventive (time-based), and predictive (condition-based maintenance). Corrective maintenance is only performed after an occurrence of a fault. Therefore, it involves unexpected breakdowns, high costs, changes in the production chain, and it could lead to catastrophic events. Preventive maintenance and interventions occur based on a scheduled maintenance plan or the equipment's mean time between failures. Although it is more effective than corrective maintenance, unexpected failure may still occur by preventing most failures. Additionally, the process cost is still high, especially the costs associated with labor, inventory, and unnecessary replacement of equipment or components.
\r\n\tOn the other hand, predictive maintenance analyses the equipment condition so that a possible fault can still be identified at an early stage. Predictive maintenance aims to identify a machine anomaly so that it does not result in a fault. Such maintenance involves advanced monitoring, processing, and signal analysis techniques, which are generally performed non-invasively and, in many cases, in real-time. In the case of machines or processes, these techniques can be developed based on vibration, temperature, acoustic emission, or electrical current signal monitoring. It should be noted that monitoring such signals or parameters to verify the operating condition is called condition monitoring. Condition monitoring aims to observe the machine's current operational condition and predict its future condition, keeping it under a systematic analysis during its remaining life. In this sense, a fault condition can be detected and identified from systematic machine condition monitoring. A diagnosis procedure can be established, whereby properly investigating the fault symptoms and prognosis.
\r\n\t
\r\n\tThis book will aim to merge all these ideas in a single volume, aggregate new maintenance experiences, apply new techniques and approaches, and report field experiences to establish new maintenance processes and management paradigms.
\r\n\t
The evolution of IoT technologies, of AI algorithms, and of cloud services allows the design of responsive products and environments, and supports the development of new approaches to the design of interactive solutions in every domain of application: human-machine, human-environment, and human-human systems [1].
These innovative solutions provide several valuable advantages for users, in terms of convenient functionalities and improved modalities of interaction between human users and technological systems. Many products and services aim to support users in the monitoring of personal well-being conditions and lifestyles, and to improve the modalities of interaction between users and the environment through the development of new control paradigms. Most of these products rely on the collection of data regarding the users and the contexts, and on their shipment to remote service providers, allowing post processing and final delivery of suitable information or other performances. Cloud data storage services, APIs offered by big companies such as Google and marketplaces such as Mashape, AI agents and other ‘pieces’ of technology, appear today as building blocks that designers can use to create useful interactive solutions for valuable experiences. Indeed, these creative opportunities are without precedents and open a new era for human beings. A new era, which as many other dawns before, carries shadow within as well as the light of new interesting and useful possibilities.
As designers, researchers, and educators in the field of interaction design [2, 3], we consider the recent evolutions of digital technologies as a great opportunity to invent/design valuable products and services. On the other hand, the creation of innovative solutions based on IoTs, on remote processing of data, and on cloud resources provides new challenges for designers. In terms of continuous updating of competences and techniques, the ability to deal with the progressive dematerialization of the object of design from fixed carrier to network and services [4], with a growing complexity of the designed systems also requiring the ability to re-define the role of designers in multi-disciplinary project teams. Furthermore, due to the dimension of the impact of digitalization on private and public aspects of life, we believe in the importance of developing a critical thinking and discussion on ethical issues emerging when dealing with radical innovation. We aim to entice the development of full awareness about the design factors that determine the acceptability and desirability of a product.
In this paper, we focus on the latter of these challenges. We intend to give a contribution to the related discussion by investigating the relationship between the physical and interactive features of the so-called smart products based on cloud computing and on responsive remote processing of data, and the dimensions of personal experience involving the sense of self and the sense of privacy. In our research, we investigate the topic in a wide perspective through a variety of different applications. We focus on products and services designed for domestic environment, the production, and use of personal data from a design perspective. We consider different applications: systems for home automation, devices to centralize the control of domestic appliances, and solutions for monitoring health and personal status.
The importance and value of data as “the new raw material of the 21st century” is now a common knowledge [5]. Defining
Indeed, the potentials of personal data collection is now amply recognized as a source of opportunities to generate new services and products, also to produce long-term consequences on the organization of main structural social assets, such as those concerning health care services, energy and resource management, public transportation facilities and so on [7]. On the other hand, dealing with personal data reveals critical issues involving safety, security, privacy, and others [8, 9]. Indeed, through the construction of digital networking of objects, spaces, and people, we are creating the new hybrid digital/physical environments where we will live in the future. Therefore, in the design of smart solutions, we face a double challenge: on one side, we must design safe solutions, protecting users from risks of fraudulent abuse of their data and of conditioning based on social engineering manipulation. On the other hand, we should avoid the risk of producing unwanted consequences on social and individual attitudes, freedom and mental frames through the shaping of interactive processes inadvertently inducing conditioning or limits. The physical world’s way of saying “The tool shapes the function” is already on the digital domain. We receive suggestions by recommender systems according to our preferences [10], we are invited dressing clothes suggested by algorithms [11], we maintain friend’s contacts under the influence of systems analyzing affinities among people, just to mention a few cases. In the current times, we no longer rely on those big social institutions (such as political or religious ones), not as much as we did in the previous centuries [12]. Automatic personal data analysis and usage present, in our opinion, the risk of shaping our life as single individual and communities, in a phenomenon that designers must be aware of.
The management of critical factors requires the joined efforts of three different domains:
In this paper, we focus on the last one, and we argue that designers should develop a better awareness of the importance of personal data’s correct handling in the development of products and services, especially for those meant for domestic use, due to the importance of home being (and being perceived as) a private and safe place, as treated later in more detail. Furthermore, we believe that the responsibility toward the correct use of personal data is one of the constraints that should be considered in the design of smart solutions, both to create suitable products and services complying laws and ethical principles, and to produce awareness.
In springtime 2016, we involved students (almost 100) of a university course in Interaction and Experience Design at the School of Design at Politecnico di Milano, in an ethnographic investigation of domestic environments. This activity produced a high number of cultural probes documenting behaviors, habits, rituals and attitudes at home, concerning people of different age, profession, and social conditions. The investigation has been part of an educational process including lectures on design for experience, and on emotional and cognitive processes involved in actions. It was not directly aimed to the design of a product or service, on purpose intending to demonstrate the suitability of aimless ethnography to provide suggestions for the creation of technology-based interactive solutions out of existing schemes. The observation on field focused on several daily tasks taking place in the domestic environments, such as entering/leaving home, entertainment and leisure, getting ready to go to bed, and so on. The collected documentation reports about feelings, expectations, values of inhabitants, and in the whole, it provides several hints toward designing suitable interactive services and products [13, 14].
With respect to the focus of this paper, the investigation produced some interesting results that can be summarized in the following statements. In our country, most people see home as a shelter and a space of freedom; a repository of most beloved objects and memories; a place to develop the most intimate relationships and where it is possible to develop a personal lifestyle. At home, it is possible to express personal esthetic preferences and values; the formal and functional organization of the house plays an important role in the definition of the sense of self.
The practical organization of objects and activities is tightly related to personal preferences and to those specific models ruling social relationships among the ones sharing the house. Part of observed people appears willing to have a tight control of the functional and esthetic settlement of their private environment; furthermore, they pay attention to their privacy and feel anxiety related to the moments when they leave/enter home.
The survey documents a variety of attitudes and behaviors, but also stresses the relevance of the topics we are focusing on, such as safety, security, and privacy. Privacy is a complex subject, since what we intend with this term varies with each person and each social environment. It also changes with time. Each single individual’s life moment and each social era have different privacy perceptions. It is also tightly connected both with personal values and cultural belongings, as well as with other feelings and attitudes such as personal freedom and sense of decency. Digital technologies make the meaning of privacy evolve, and pose new challenges and questions in terms of civil laws concerning ownership.
In order to design acceptable and desirable home automation solutions, designers should consider reliability of products and services toward privacy needs a primary issue, to be managed through suitable design choices.
We, as human, live and act in the space around us. Smart environments, smart and wearable objects, and IoTs detect precise information about us and about our behavior through sensors’ data. These products have become part of people’s contexts as everyday objects in the private field, at work, and in the different outdoor activities. They represent an evolution of the use of the everyday objects, driving technology, with its power and possibilities, to be imperceptible. Smart and reactive environments are made not only by integrated systems, but also by everyday objects that evolve in nodes of an interconnected network collecting, storing, processing, and spreading information. The use of these objects creates a set of personal information that is useful for various functions of the object itself and for the integration of new functions and services as well.
Although this information is undoubtedly useful for the operation of proactive and intelligent systems, it is necessary to face the effects on user’s sensitivity and awareness concerning the collection and spreading of information about them.
We intend
As designers, we embrace the creative potentials connected to several dimensions of existence made possible by digital technologies. On the other hand, we recognize the control of one’s personal information as a natural and universal right of the ones producing them, and dealing with the design of domestic smart appliances, we consider it as a primary issue.
The collection of data through the use of wearable devices such as smart-watches, or through the sensors embedded in most smart phones (accelerometers, audio and video recorders, light sensors, GPS, and so on), allow the processing of personal information on behaviors and contexts, producing valuable and affordable tools to monitor lifestyles and personal health conditions. The sensors integrated in devices as Fitbit for lifestyle, Beast for sport performance, and MedicAlert bracelet for epilepsy monitoring [21–23] allow these devices to constantly detect biological parameters and process data to create value for the users. These systems provide the opportunity to record information to be shared with caregivers, but also to obtain immediate feedbacks thanks to online processing of personal data and the use of suitable algorithm for the modeling and interpretation of activities and contexts.
This approach to the use of personal data on devices and IoT solutions is not strictly related to health monitoring: it is currently widely spreading in many fields of application, such as sports and work performance.
Analyzing the home automation products and services, the personal data stand out as a sort of raw material to be analyzed, processed, and crossed with other data aiming to enable functions and proactivity of the system. The user can perform different actions through the use of automated systems in the intimate context of the home. Actions spanning through the precise control, monitoring, pre-set of single activities or functional scenarios for the home ambient. The products used in the home context are not only related to the automation of home appliances or integrated systems. There are plenty of single devices that perform single or multiple functions for well-being, lifestyle, and personal health of the people living in the house. Despite some of these solutions are made to be functional in everyday life, also out of the home environment, our aim is to analyze them in the intimate context of the home to understand how they are perturbing the intimacy by managing of personal information. Personal data are collected by the devices both using integrated and connected sensors that detect precise values directly and using other devices and appliance to receive second hand information on the users’ habits and behaviors.
Picking devices and systems examples from market and crowd funding, we aim exploring the current methods and possibilities offered by home automation solutions concerning use of personal information and data. We consider the two main branches of home automation solutions that use personal data while controlling and managing devices and appliances. The first one includes applications that aim to provide and monitor health and well-being. The second one includes applications that aim to simplify and help in everyday and occasional tasks.
The health monitors and well-being providers such as Cubile Health and Sleep Cycle Alarm Clock [24, 25] are focusing on
The controller devices and appliances aim to simplify users’ task and to optimize time and efforts and they collect data directly (from integrated sensors) or through other objects and appliances. Whether they are single devices or integrated systems, they usually merge and cross different data to create value for the user performing task managing through direct control of appliances and devices or giving useful information and feedback to the final user. Modern integrated systems for home automation can control every connected device (e.g. KNX systems) and let the house act as a semi-autonomous agent acting accordingly to given presets, customized settings or even user’s habits. Home automation integrated system as well as single devices mainly collect data from user’s behaviors through objects using both integrated sensors or simple operation habits (e.g. timing and frequency of switching on/off for a single device) to permit customized objects’ performances. Single devices as the Samsung Family Hub 2.0 [27] smart fridge collect and analyze users’ foods and shopping preferences to manage purchases, storage, and monitoring actions for the users. These data reveal behaviors of the user to perform a task optimization and to give proactivity to the device. Control hubs as Amazon Echo [28] constantly monitor the environment to detect users’ needs and use AI to perform personalized tasks or suggestions accordingly to his ‘perception’. An Experian survey [29] shows that Echo users are likely to place the device in the kitchen. This is probably because it is easily accessible with occupied hands, so the voice recognition used as task manager (smart light and thermostat control, add item to a shopping list, provide information, play music, and so on) is probably the key of the success of its AI Alexa [30]. Amazon Echo uses on-device keyword spotting to detect the
Whether we divided cases in the two branches of use of personal data, some of these solutions actually belong to both, presenting a data usage dual mode. One of these is Moodbox: it can simply react to movement, switching on when somebody walks across its monitored space, but also crosses data from voice analysis and favorite music, weather conditions and time of the day, using artificial intelligence to suggest music that the user will probably like being in a particular mood. All these systems and devices learn from user actions and try to anticipate them, letting users free to use and manage their time in a different and maybe more important way.
While analyzing these cases, an issue arises: is generated info value meaningful enough to absorb the privacy perturbation? The resilience of a technology can be a discriminating factor to its adoption. The real value for the user, being it monetary or service, must compensate not only the effort employed in the use of the device, but also the perception of ‘loss of control’ over their personal data (Figure 1).
Personal data management and use in the analyzed home automation solutions.
The reflections above reported lead us to define pointers we wish to discuss within the communities of designers of interactive products and services. The topic is vast and complex, and, due to digital technologies rapid evolution, it requires an open discussion capable to face the continuous ongoing change.
As temporary principles, we assume that, in the creation of interactive digital products and services involving personal data, designers should:
Provide users with both a full and explicit information about the ways their personal data are employed by the product/service along the whole chain of exchange of information by different stakeholder and a meaningful
Provide sufficient protection toward improper or unjustified use of personal data by third parties aiming to fraudulent actions or to exert persuasion through tailored advertising.
Make people aware of most common social engineering use of personal data.
Avoid reduction of resilience and robustness of home technical systems involving cloud computing and data processing, and due to the aleatory performances of the internet and to the characteristics of technological devices, such as smart phones, presenting intrinsic risks in terms of fragility and the possibility to be lost/taken.
Provide usable and accessible means for users to enable/disable the data gathering, and to simplify the control and management of the data concerning the persons and the environment, that are exchanged by the product and system, in any time and any context.
As a last inducement, we suggest to consider as a natural human right, the possibility for the user to ‘negotiate’ the personal data as a matter of design: if data is framed today as a resource and a capital, everyone should be allowed to manage their own as property.
This work has been partially funded by TIM S.p.A., Service Innovation Department, Joint Open Lab S-Cube, Milano, Italy.
For years, Africa has rolled out efforts to assert its position within a globalized “village.” In some cases, the continent has been presented as torn apart between having either to appropriate new systems and risk annihilation by western systems (and culture) or to recreate its systems enshrined in its culture (or indigenous knowledge systems) in order to regain its rightful place in a globalized world. Globalization, as Yankuzo [1] argues, is a critical tool for cultural homogeneity designed to end cultural diversity in the world. This means, diverse cultural values are replaced by global cultural values, and the varieties of social and cultural developments have been fuelling globalization over the years. Furthermore, Yankuzo [1] believes globalization as a phenomenon has “a multi-dimensional process, whereby cultural, economic and political relations increasingly take a global basis” (p. 2). Against this view, what it means is that Africa continues to negotiate for space in this globalized space. Africa’s traditions, practices, and discourses reflect that the continent has not been annihilated by globalization. Instead, Africa continues to mark its unique space in varying ways.
\nIn Africa, the “rural landscape” has been characterized in the discourses as the source of African sensibilities. The African village is a granary of that which is African [2], with the urban landscape providing contrasting images tied to westernization, urbanization and all forces of modernity. African indigenous knowledge systems have extensively shown how the rural landscape has been the sanctuary of African culture, traditions and values. Urbanization, in contrast, has been projected as a threat to these values. One reason behind the continued smoking of the
Even African literature, reflects aspects of cultural erosion. For instance, Lucifer in
This chapter, therefore, architecturally explores selected outdoor spaces in Zimbabwe. The chapter argues that the new places symbolize and represent African culture in terms of homage, food, hospitality and cultural security. Furthermore, it is argued that while this triggers nostalgia to Africans, the spaces offer an eyrie of cultural values as housed in the architecture as well as names of the spaces in order to communicate African sensibilities about the African aura of the traditional village at the same time sustainably conserving the architecture authored by African heritage. One of the conclusions made is that the urban landscape can store and communicate African heritage, interestingly, requisite architecture can be used in this endeavor.
\nThe chapter also argues that the naming and architectural systems also reflect modernization as well as a sense of economization of the African village since those behind the naming and constructions are taking advantage of the economic opportunities presented by the twenty-first century land reform program. It is further shown that African culture has thus survived or is given a lifeline by being repackaged, modernized and appropriated in the new terrain; a terrain where modernity forces and processes have in some way sort over the years to delete ultimately, African sensibilities.
\nData for the study were gathered qualitatively. Interviews with owners (and consumers) of selected lodges and restaurants were conducted during visits undertaken to such spaces by the researcher. Participant observations were also done as the researcher participated in various activities organized at such spaces such as weddings, workshops, parties, and various other social activities. Furthermore, extensive desktop research was conducted to enrich the study. In order to lay the foundation for my discussion and reporting, first, an aside on the twenty-first century Land Reform Program in Zimbabwe is done to put the discussion into context.
\nDocumentation of the twenty-first century land reform, dubbed the Fast Track Land Reform Program (FTLRP) in Zimbabwe, is quite visible, and there is a considerable corpus of studies on the land issue in the country. Some scholars have called land issues in the country,
In her report, Tibaijuka [9] reveals the many sidedness as well as many faces created by the land reform in the country. For instance, there are narratives detailing the dynamics of Operation
… the racially-skewed agrarian structure and discriminatory land tenures inherited from colonial rule, whereby over 6000 large-scale white farmers and a few foreign and nationally-owned agroindustrial estates controlled most of the prime land, water resources, and bio-reserves, while relegating the majority of the population to marginal lands and cheap-labor services. ([13], p. 1)
\nThe twenty-first century land reform program in Zimbabwe also attracted the attention of the international community and imagination. For the locals, it rekindled memories of the past mostly tied to colonialism and its land policies. Mutondi [14] notes that for the Zimbabwean people, it was also about economic empowerment read as “the final embodiment of empowerment following Zimbabwe’s independence in 1980” (p. 1). Political interpretations of the land reform program were two sided. Drivers of the program claimed the program was overdue. The then President, Robert Mugabe, declared in 2005 that
\nwithout doubt, our heroes are happy that a crucial part of this new phase of our struggle has been completed. The land has been freed and today all our heroes lie on the soil that is declaration. Their spirits are unbound, free to roam the land they left shackled, thanks again to the Third Chimurenga. ([14], p. 2)
\nDefenders, mostly beneficiaries of the land reform (mostly politicians), projected the program as successful. The defense was centered on the recentralized “decision-making relating to land matters, ostensibly because [the government] perceived itself as fighting against external forces bent on reversing the gains of the program” ([14], p. 4). Thus, political statements and action were pitched very high in order to hide certain local tendencies (some of the action relating to the land takeovers was permeated by violence), which made it difficult to discern what was happening on the ground ([14], p. 4).
\nChief among the defenders of the program was the government, its institutions, agents, and officials. But those opposed to the government’s model placed at the center “human rights violations” along racial, sometimes tribal lines. The white Zimbabweans were characterized as victims, and black supporters of this were also seen as victims too. The Mugabe government characterized black people who opposed its stance and model of the program as lacking totems, connections to the Zimbabwean culture and identity; stooges meant and being used to reverse the gains of the armed liberation struggle that brought independence in 1980.
\nPerhaps, the politically charged periods of 2000–2008 rendered the program more political than economic or sociocultural. As such, studies done during the same period tended to take the same lines with conclusions being submitted as the program being unsustainable rather than a socially and economically sustainable developmental drive for the people of Zimbabwe. Almost two decades after the FTLRP, research and discourses now center on measuring the success of the land reform based on arguments around poverty reduction and economic efficiency with political considerations gradually wearing away.
\nRegardless of the cost in humanitarian sense, economic, political, and social complexities as well as dynamics, the program created economic opportunities for the locals around land ownership. Not only did the land reform address agrarian related land ownership and utilization, but residential as well as commercial land was also made available for expansion of existing settlements as well as for creation of new settlements and economies. It is this reading of the program, which opened up economic opportunities in terms of the availability of commercial land, which this chapter heavily sides with. The new spaces have allowed repackaging of “tradition,” specifically repackaging of the traditional African village architecture and subsequent naming of the created spaces since most owners became locals.
\nBuildings and their subsequent names are semiotic resources. Semiotics is used to view buildings as objects as well as respective place names as resources in the construction as well as naming patterns and systems of the landscape itself. Not only does this empower us to interpret meanings carried by lodges and restaurants, but also this alludes to the language of the landscape as it has come to communicate a variety of messages.
\nWhen linguistic sign systems are used either as names, strings of sentences, or lexical items, the sign systems create a signifying system. Ikegami ([15], p. 1) calls such a system a “meaning-generating” system “observable in the cultural spheres they are dealing with” ([15], p. 1). The science (sometimes approach) dealing with signs, their systems, and general function in meaning making as well as interpretation is known as
Broadly speaking, semiotics is a phenomenon in which something is used to stand in for something else. De Saussure [16] and Pierce [17] used “semiology” and “semiosis,” respectively, which, in modern semiotics, are basically understood as semiotic processes. With reference to “semiosis,” [15, 18] human beings operate and survive by evaluating as well as assigning significances and values to things, phenomena “around him
Semiotic knowledge teaches us that anything can function as a sign since signs do not have predetermined properties. This also means that buildings and their names do not have predetermined properties as such function as semiotic signs. However, the observable properties of signs are in fact defined in terms of their relation to what they represent. Johansen and Larsen ([19], p. 26) say signs are an “inconspicuous part of our everyday existence” revealing a triadic relation among sign, object, and interpretant.
…semiotics can…be thought of as an applied science, in that it serves as an instrument for the study of empirical objects, or rather for the description and analysis of concrete products of language, whether they be a poem, a theorem, a piece of music, a utilitarian object, a rite, a political speech, a play, an art object, a movie, a TV program, etc. In short: each and every linguistic manifestation. (p. 115)
\nFrom the above, we note that aspects from which meaning making especially through language and its use is fertile ground on which semiotics can be and has been used. Riffaterre (in Champagne ([21], p. 229)) used semiotics to analyze French poetry for the simple reason that “poems are … assumed to be closed units of meaning …” Hale [22] speaks of Umberto Eco as having used semiotics in the writing of his novels notably
Architectural objects such as buildings and their names within a landscape form a language. They are units of a landscape language. Their creation and use create patterns and communicative sign systems. Furthermore, buildings and space place names derive their energy from one who designs, constructs, and names them. This means there are even power dynamics as well as circumstances or events that may be involved in the designing, constructing, as well as naming of a thing or a place. The colonized participated too in various ways in naming as well as erecting buildings from their worldview, thus creating places and spaces in response to new realities they now experienced.
\nPlaces, spaces, and objects (buildings), therein, follow the triad and a variety of signs [16, 17]. We find them either as
The practices and systems observable in contemporary Zimbabwe mark out the definition and “ownership” of spaces created by the land reform program. The program empowered the locals to design, construct, and “name” these new spaces. Remember, to name is to control; thus, the locals who partook in setting up the said lodges and restaurants also named new spaces as a reflection to the newly found economic opportunities. They have done so consciously aiming at creating indigenous spaces in order to evoke as well as communicate African sensibilities and their heritage.
\nIn this section, I report as well as describe the architecture of some of the most prominent lodges and restaurants. While owners of these places are locals, the common names I observed as well as the outlook of their architecture had some resemblances distinguished mostly by locality and ownership. Both male and female locals have ownership of the spaces, and in some cases, this appeared to some extent to determine the naming patterns as shall be discussed below. The physical space location of the lodge or restaurant was noted to be the most distinguishing factor with ownership varying significantly. The following are some of the place names.
\n“The village lodge” was observed to be a common space for newly established lodges dotted in considerable outskirts of main towns and cities in Zimbabwe, mostly in Midlands and Mashonaland provinces. In terms of naming, what is key in this place name is the prefixing of the main economic activity “the lodge” with the lexical item “village.” These spaces apart from offering overnight accommodation for travelers, they also have restaurants and conference rooms, hence, not only favoring for overnight accommodation, but also offering venues for the conduction of various other social activities such as wedding ceremonies, business workshops, and conferences. Owners did not hide their niche from the naming patterns as expressed grave desire in making a mark in the hospitality industry, and thus, the name “village lodge” was in itself suggestive of an African-centered ambient for the conduction of the above activities.
\n“Chicken hut” in contrast to “the village lodge” was observed as primarily a restaurant or eating space where dominant meals served are poultry-centered one. Beyond offering restaurant facilities, hiring out of basic catering services are also offered for weddings and other gatherings, which may be staged far removed from their physical locality. Nonalcoholic beverages are also served with the said meals. The irony, however, lies in which the poultry-centered meals served are mostly based on foreign menus with Italian, French, and Greek as well as American being much popular. Physical location of the spaces was generally observed to be within the central business districts of the towns or cities.
\n“
The “village” concept reveals African cultural values, which include and designed to reveal a sense of community life, a sense of good human relations, a sense of the sacredness of life, a sense of hospitality, a sense of time, a sense of language, and proverbs to mention a few. The vernacular architecture and naming of the above places against the “village concept,” hence, signify and symbolize much of this African village concept. To appreciate the African values attached to the “village,” we note that in terms of the “sense of community life” offered by the African village; traditionally, Africans believe that the community is the custodian of the individual. In the material reference to the phrase, the individual must thus return or go to the “community center” or village square, which is a social, political, judicial, and religious center.
\nOf the view that, “today, many urban Africans coming from a village and argue that it is in the village where traditional African culture can still be found” ([6], p. 51), it follows the locals in Zimbabwe after the FTLRP by ridding on the village concept are in fact aiming at establishing as well as producing locality in order to redefine themselves as “actors who properly belong to a situated community of kin, neighbors, friends, and enemies” ([29], p. 179). Lucifer, in
Furthermore, in terms of the “sense of good human relations” attached to the village concept, we learn that relationship between individuals reveal their worth as human beings, hence, the art of dialog, discussion of problems, and searching for solutions through dialog. Within the spaces presented above such as
In social conversations cited above, identification of each other and general “totemic” use to reflect individual ties is common, traditional and brings about a sense of belonging. Hence,
In terms of
To reveal aspects of traditional African architecture characterizing the new spaces and how these have been enriched, an appeal to the structures is worthwhile. Hence, the physical structures marking the spaces are important. The African village, traditionally, is characterized by the “hut”; in other words, the hut is made up of wooden poles and clay soils are used to patch up the walling poles. In terms of the roof, again wooden poles are used and they are grass thatched. The buildings are conically shaped, and a collection of such huts in a defined space creates a “village” as exemplified in Figure 2a and b.
\nIn modern spaces, the same concept (as shown in Figure 1) is also being used where grass thatched buildings (but now in brick and cement walls) are now the common feature (see Figure 2a and b). The shape or designs of the buildings are conical, and the roofs are grass thatched as exemplified in Figure 2a and b.
\nTypical African village made up of conically shaped and grass thatched grass.
(a) Round huts built with modern materials, (b) grass thatched huts for a lodge, (c) a view from the inside modern hut, (d) how some of the lodges are advertised, and (e) the ambience and outdoor set-ups of the lodges.
In some lodges, for instance, “the village lodge” in Gweru (Midlands Province) offers overnight accommodation, and rooms are “huts” (although equipped with modern furniture and other utilities inside as shown in Figure 2c and d). One sees dotted huts within the physical spaces where the lodges have been built. The rooms are also named (rather than numbered) after either game or totems. This represents much of the traditional African village and its surroundings.
\nSecond, the food served involves traditional meats, insects, grasses, and vegetables. Utensils used are wooden symbolizing much of the African village practices on food consumption.Meals come in to complete the ends of the architecture and designs The outdoor spaces of the lodges are designed as if to place patrons in a “bush” bringing them close to “nature” as shown by Figure 2e. One has a sense of the natural ambience and for Africans such set-ups trigger nostalgia.
\nFurthermore, entertainment provided in the same spaces as well as the general ambient reflects African traditions as well. Traditional music, dances, and performances are organized for revelers especially in lodges and those restaurants located at the outskirts of towns and cities. These three characteristics enrich the buildings and their names chosen as the spaces named should have characteristics that support the totality of that which is found in a traditional village.
\nThe reconstruction of the African village is, thus, observed from a number of fronts. First, there is a deliberate designing and construction of the new spaces. The “huts” are conical in shape and now being constructed using modern building materials in tandem with changes that have happened over the years. While traditionally poles were used, due to advances in technology, modern bricks, and cement are now being used for walling. However, the roofing is made up of treated poles and is grass thatched. The processes involved in upholding the architecture under discussion reveal costs implications at the same time bringing about some economic activities involved in the construction and maintenance of such spaces. To exemplify this, we note that suppliers of food stuffs to be prepared such as insects, traditional grasses (and vegetables), meats, and so on have taken an economic drive.
\nDuring the construction phases themselves, the grass is bought, and treated tree poles are supplied and used with modern building materials such as cement and bricks to create an African ambient. Traditional dance groups as well as musicians of traditional music such as
…others resided in the cities for many years. But even those who spent their entire working life in the city intended eventually to return to their hometowns. This is reflected in the visits that many of the more permanent migrants made to the village, usually around Christmas. ([6], p. 62)
\nBut for Zimbabwe, while van den Bersselaar’s [6] views are valid, even in historic Zimbabwe, the land reform program further redefined and created more opportunities for a greater percentage of the population to migrate to the city mostly for economic opportunities. In some cases, there is a total disconnection of some Zimbabweans from their rural homes especially under circumstances where none of their parents are surviving who in most cases are the elderly who may have retired to their rural homes. Hence, visiting newly created villages in the cities is thus in some cases symbolic journeys to their villages as well as their past. Further engaging the above, Saidi [30] observed that,
\nGiven that Africans have for long battled with cultural erosion and identity crisis, African people exhibit and continue to reflect effects of spiritual tension with their culture and environment. Their connections to “mother earth” have over the years been loosened. However, with vernacular architecture and the recreation of the “new” landscape, it is hoped that the feeling of reconnection and returning to the source can be awakened as the concretization of the meanings of nature and aspects from their natural environment communicated through objects that trigger visualization, representation and symbolization of their heritage can foresee creation of a place where buildings act as an extension of the interior as well as cultural and spiritual space. (p. 13)
\nThis reflects a great deal of aspects of heritage conservation, which is being done architecturally. Heritage can be both tangible and intangible, and there is a thin line that divides the two. Tangible heritage refers to the material objects that are seen or those that can be touched. On the other hand, “intangible heritage” generally refers to that heritage, which is usually experienced. According to “intangible heritage, it is often regarded as traditional culture that reflects the identity of a particular nation or group.”
\nFrom the above submission, the architecture of the new spaces discussed above has become the pivot for the tangible and intangible heritage more so that the traditional village concept has come to be conserved in a unique way and continues to be used in contemporary times. The conclusion that Hărmănescu and Enache [31] make in as far as vernacular knowledge in architecture is concerned come in handy. They say that,
\nThe past offers growth recourses for the future through the knowledge gained. In this case, the future should recognize the past value offering identity of those who use and transmit knowledge. To ignore the past, the vernacular knowledge of a place means to waste resources knowledge of a place. (p. 415)
\nThis speaks to efforts far removed from the increasingly and deliberate strategies in the twenty-first century “to preserve and conserve natural areas to prevent their degradation and to halt the innumerable attacks to which the industrial model of economic development has subjected the planet” ([31], p. 29). While the world has been so grossed with conserving “natural areas” by enacting legislature for instance, there has not been interest in coming up with the strategies to conserve some important aspects, especially intangible heritage in Africa. For Zimbabwe, therefore, the vernacular architecture has come to play this conservation role of culture as the landscape heavily came under construction within terrains far removed from natural sites where international legislature may force the country to protect the landscape. It is also important to note that what is being conserved here are not the buildings per se but the traditional architectural designs, activities, relations, and cultural identities of spaces, thereby promoting consumption as well as “visualization, representation, and symbolization” ([30], p. 13) of Africa’s habitant heritage.
\nShetabi [32] points out that built heritage has an important role to play in them expressing tangible and intangible values. In other words, buildings, based on their architecture, names and objects therein, are visual links to the past, revealing how communities evolve socially, technologically, and culturally. The above discussed buildings and spaces are proof to this line of thinking in Zimbabwe. These efforts should be encouraged because if the world is experiencing “the largest wave of urban growth in history” ([33], p. 1) and that by 2050 and that by 2050, 66% of the world’s population will reside in urban areas [33], it also means that the entire world is currently experiencing challenges in terms of balancing cultural heritage conservation and the requirements of urbanization. Zhang et al. ([33], p. 1) are thus right to point out that
\nIn this context, sustainable development, which is a complex, multidimensional, and evolving concept that encompasses environmental, economic, social, developmental, and cultural components, is highly valued worldwide.
\nIt follows, therefore, that Zimbabwe has begun to witness architectural maneuvers in seeking to balance environmental, economic, social, developmental, and cultural components in which mere citizens are taking a leading role as custodians of their heritage by turning their private spaces into cultural centers that house vernacular architecture.
\nBroadly speaking, the designs, constructions, and naming of lodges and restaurants after the FTLRP signify African traditional sensibilities recreated in the urban terrain. It further means that not everything has been lost in as far as cultural values are concerned among Zimbabweans. The “new” lodges and restaurants represent the African sensibilities and subsequently identity in a contemporary global village. In the same breath, we may, however, be forced to make an aside that if places, whose primary function is for business or money making, are constructed and named using traditional sensibilities, how far are the cultural values given center stage?
\nThere is no doubt that constructions and naming of the places are also a marketing strategy where owners draw from their culture, and there is no sure way of ascertaining whether this is a purely economic drive, cultural drive, or both. Whether owners are conscious to cultural values or not, in what has been characterized by the likes of Ngugi [2] as Africa’s problem being led by the culturally eroded and neo-colonial elites, there is evidence of attempts to recreate the traditional African family based on the village concept. From the nature of buildings and their names, it cannot be divorced that locals share and communicate the traditional past through physical objects, space, and the various aspects therein such as artifacts, foods, music, and dance.
\nPerhaps, this is so because there has been a realization that indigenous identity is important for the survival of any people. Hence, the repackaging of new spaces is not only for cultural survival, but also for economic redefinition supported by heritage through vehicles such as vernacular architecture and names of these public spaces like lodges and restaurants. These are efforts in Zimbabwe to “Africanize” the urban terrain. Therefore, urban buildings and their names as well as studies of the same indeed can help greatly in packaging indigenous knowledge systems for the survival of African heritage. We note that the urban landscape/spaces can actually store and communicate the heritage as well as history of the African people if systematic packaging and support is rendered to initiatives such as discussed above. We should be on the lookout, however, that at the center of it, all should be value exerted on culture and heritage since tagging monetary figures on traditional values may see traditions being consumed without pedigree desires for conservation, and this may be detrimental to that which has been left of the African heritage.
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Although PSA has led to decrease in prostate cancer–related mortalities, PSA is a nonspecific prostate cancer biomarker reflective of other prostate-related conditions such as benign prostatic hyperplasia (BPH), resulting in a high false-positive rate. This has led to overtreatment of men with clinically insignificant disease. While most prostate cancer patients have slowly progressive disease and should be treated conservatively, roughly 10% of patients will progress to have metastatic disease, of which the majority of prostate cancer deaths can be attributed. Stratifying these patients based on prognosis so that they may benefit from aggressive treatment is critical to their survival. Biomarkers for prostate cancer diagnosis and subsequent prognostic screening have significantly advanced this field. Here, we review some of the current blood, tissue, and urine biomarker tools used to measure an array of molecules including DNA, RNA, protein, or even epigenetic modifications. Utilizing the technologies described here, as well as looking to the future, correct early identification of prostate cancer with powerful prognostic value is much closer than ever before.",book:{id:"7126",slug:"prostatectomy",title:"Prostatectomy",fullTitle:"Prostatectomy"},signatures:"Meghan A. Rice and Tanya Stoyanova",authors:null},{id:"51256",doi:"10.5772/63965",title:"Pathogenesis of Human Papillomavirus – Immunological Responses to HPV Infection",slug:"pathogenesis-of-human-papillomavirus-immunological-responses-to-hpv-infection",totalDownloads:2150,totalCrossrefCites:3,totalDimensionsCites:8,abstract:"Papillomavirus is an oncogenic virus which infects mucosal and cutaneous epithelia where it induces benign hyperproliferative lesions. Few studies have been conducted on the causative factors associated with the development of cancer. Infections by high-risk human papillomaviruses (HPVs) have been implicated as causative agents in a variety of cancers such as anogenital, and head and neck cancers. HPVs appear to have evolved mechanisms resulting in escape from host immune surveillance and delay of resolution of infection. The HPV E5 oncoprotein is one of the possible effectors that allows the virus to escape from host immune system through the downregulation of surface classical major histocompatibility complex class I (MHC I) and not the nonclassical MHC I. Lack of classical MHC I in infected cells expressing E5 would allow evasion of cytotoxic T lymphocytes (CTLs) killing and thus establishment and persistence of viral infection.",book:{id:"5256",slug:"human-papillomavirus-research-in-a-global-perspective",title:"Human Papillomavirus",fullTitle:"Human Papillomavirus - Research in a Global Perspective"},signatures:"G. Hossein Ashrafi and Nadia Aziz Salman",authors:[{id:"180711",title:"Dr.",name:"Hossein",middleName:null,surname:"Ashrafi",slug:"hossein-ashrafi",fullName:"Hossein Ashrafi"},{id:"185528",title:"Dr.",name:"Nadia",middleName:null,surname:"Aziz Salman",slug:"nadia-aziz-salman",fullName:"Nadia Aziz Salman"}]},{id:"50425",doi:"10.5772/62833",title:"The Involvement of Epigenetic Mechanisms in HPV‐Induced Cervical Cancer",slug:"the-involvement-of-epigenetic-mechanisms-in-hpv-induced-cervical-cancer",totalDownloads:1654,totalCrossrefCites:2,totalDimensionsCites:7,abstract:"High‐risk human papillomavirus (HPV) genotypes infection associates with cervical dysplasia and carcinogenesis. hr‐HPV transforming potential is based on E6 and E7 viral oncoproteins actions on cellular proteins. A persistent infection with hr‐HPV leads to progression from precursor lesions to invasive cervical cancer inducing changes in host genome and epigenome. Pathogenesis and development of cancer associated with both genetic and epigenetic defects alter transcriptional program. An important role for malignant transformation in HPV‐induced cervical cancer is played by epigenetic changes that occur in both viral and host genome. Furthermore, there are observations demonstrating that oncogenic viruses, once they integrated into host genome, become susceptible to epigenetic alterations made by host machinery. Epigenetic regulation of viral gene expression is an important factor in HPV‐associated disease. Gene expression control is complex and involves epigenetic changes: DNA methylation, histone modification, and non‐coding RNAs activity. Persistent infection with hr‐HPV can cause viral DNA integration into host genome attracting defense mechanisms such as methylation machinery. In this chapter, we aim to review HPV infection role in chromatin modification/remodeling and the impact of HPV infection on non‐coding RNAs in cervix oncogenesis. The reversible nature of epigenetic alterations provides new opportunities in the development of therapeutic agents targeting epigenetic modification in oncogenesis.",book:{id:"5256",slug:"human-papillomavirus-research-in-a-global-perspective",title:"Human Papillomavirus",fullTitle:"Human Papillomavirus - Research in a Global Perspective"},signatures:"Adriana Plesa, Iulia V. Iancu, Anca Botezatu, Irina Huica, Mihai\nStoian and Gabriela Anton",authors:[{id:"80114",title:"Dr.",name:"Gabriela",middleName:null,surname:"Anton",slug:"gabriela-anton",fullName:"Gabriela Anton"},{id:"88744",title:"Dr.",name:"Anca",middleName:null,surname:"Botezatu",slug:"anca-botezatu",fullName:"Anca Botezatu"},{id:"167968",title:"Dr.",name:"Adriana",middleName:null,surname:"Plesa",slug:"adriana-plesa",fullName:"Adriana Plesa"},{id:"185918",title:"Dr.",name:"Iulia V.",middleName:null,surname:"Iancu",slug:"iulia-v.-iancu",fullName:"Iulia V. Iancu"},{id:"185919",title:"Dr.",name:"Irina",middleName:null,surname:"Huica",slug:"irina-huica",fullName:"Irina Huica"},{id:"185920",title:"Dr.",name:"Mihai",middleName:null,surname:"Stoian",slug:"mihai-stoian",fullName:"Mihai Stoian"}]}],mostDownloadedChaptersLast30Days:[{id:"44311",title:"Molecular Tools for Detection Human Papillomavirus",slug:"molecular-tools-for-detection-human-papillomavirus",totalDownloads:2467,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"3395",slug:"human-papillomavirus-and-related-diseases-from-bench-to-bedside-a-diagnostic-and-preventive-perspective",title:"Human Papillomavirus and Related Diseases",fullTitle:"Human Papillomavirus and Related Diseases From Bench to Bedside A Diagnostic and Preventive Perspective"},signatures:"Angela Adamski da Silva Reis, Daniela de Melo e Silva, Cláudio\nCarlos da Silva and Aparecido Divino da Cruz",authors:[{id:"68829",title:"Dr.",name:"Angela",middleName:"Adamski Da Silva",surname:"Reis",slug:"angela-reis",fullName:"Angela Reis"},{id:"121027",title:"Dr.",name:"Aparecido Divino",middleName:null,surname:"Da Cruz",slug:"aparecido-divino-da-cruz",fullName:"Aparecido Divino Da Cruz"},{id:"161255",title:"Prof.",name:"Daniela De Melo",middleName:null,surname:"Silva",slug:"daniela-de-melo-silva",fullName:"Daniela De Melo Silva"},{id:"166363",title:"Prof.",name:"Cláudio Carlos",middleName:null,surname:"Da Silva",slug:"claudio-carlos-da-silva",fullName:"Cláudio Carlos Da Silva"}]},{id:"62729",title:"Preventing Erectile Dysfunction after Radical Prostatectomy: Nerve-Sparing Techniques, Penile Rehabilitation, and Novel Regenerative Therapies",slug:"preventing-erectile-dysfunction-after-radical-prostatectomy-nerve-sparing-techniques-penile-rehabili",totalDownloads:2023,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Erectile dysfunction is a known and much-dreaded functional consequence of radical prostatectomy. Dr. Patrick Walsh pioneered the nerve-sparing radical retropubic prostatectomy in the early 1980s, which has mitigated the morbidity of this surgery. Post-operative potency rates range widely from 20 to 80%, however, and depend on myriad factors including age, preoperative potency, and degree of nerve-sparing during surgery. Over the past four decades several developments have continued to offer hope to patients and clinicians alike, including refined understanding of cavernosal nerve neuroanatomy, beneficial modifications in surgical technique, as well as the advent of robotic surgery. Furthermore, multiple pre- and post-operative penile rehabilitation techniques using mechanotherapy and pharmaceuticals have also improved functional recovery. This paper examines erectile dysfunction as a consequence of radical prostatectomy, including the physiology of erections, the pathophysiology of post-operative erectile dysfunction, novel surgical techniques to enhance neurovascular bundle preservation, and penile rehabilitation strategies involving hyperbaric oxygen, neuroprotective pharmaceuticals, dehydrated human amnion-chorion membrane allografts, and mesenchymal stem cell therapy.",book:{id:"7126",slug:"prostatectomy",title:"Prostatectomy",fullTitle:"Prostatectomy"},signatures:"Michael Whalen",authors:null},{id:"62783",title:"Biomarkers for Diagnosis and Prognosis of Prostate Cancer",slug:"biomarkers-for-diagnosis-and-prognosis-of-prostate-cancer",totalDownloads:2138,totalCrossrefCites:4,totalDimensionsCites:8,abstract:"Since its discovery, elevated prostate-specific antigen (PSA) has been the measurement to indicate possibility of prostate cancer, as well as biochemical recurrence following treatment. Although PSA has led to decrease in prostate cancer–related mortalities, PSA is a nonspecific prostate cancer biomarker reflective of other prostate-related conditions such as benign prostatic hyperplasia (BPH), resulting in a high false-positive rate. This has led to overtreatment of men with clinically insignificant disease. While most prostate cancer patients have slowly progressive disease and should be treated conservatively, roughly 10% of patients will progress to have metastatic disease, of which the majority of prostate cancer deaths can be attributed. Stratifying these patients based on prognosis so that they may benefit from aggressive treatment is critical to their survival. Biomarkers for prostate cancer diagnosis and subsequent prognostic screening have significantly advanced this field. Here, we review some of the current blood, tissue, and urine biomarker tools used to measure an array of molecules including DNA, RNA, protein, or even epigenetic modifications. Utilizing the technologies described here, as well as looking to the future, correct early identification of prostate cancer with powerful prognostic value is much closer than ever before.",book:{id:"7126",slug:"prostatectomy",title:"Prostatectomy",fullTitle:"Prostatectomy"},signatures:"Meghan A. Rice and Tanya Stoyanova",authors:null},{id:"41843",title:"The Role of E-Cadherin-Catenin Complex in Prostate Cancer Progression",slug:"the-role-of-e-cadherin-catenin-complex-in-prostate-cancer-progression",totalDownloads:2453,totalCrossrefCites:0,totalDimensionsCites:1,abstract:null,book:{id:"3274",slug:"advances-in-prostate-cancer",title:"Advances in Prostate Cancer",fullTitle:"Advances in Prostate Cancer"},signatures:"Anuradha K. Murali and James S. 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Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. 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He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:48,paginationItems:[{id:"81799",title:"Cross Talk of Purinergic and Immune Signaling: Implication in Inflammatory and Pathogenic Diseases",doi:"10.5772/intechopen.104978",signatures:"Richa Rai",slug:"cross-talk-of-purinergic-and-immune-signaling-implication-in-inflammatory-and-pathogenic-diseases",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81764",title:"Involvement of the Purinergic System in Cell Death in Models of Retinopathies",doi:"10.5772/intechopen.103935",signatures:"Douglas Penaforte Cruz, Marinna Garcia Repossi and Lucianne Fragel Madeira",slug:"involvement-of-the-purinergic-system-in-cell-death-in-models-of-retinopathies",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81756",title:"Alteration of Cytokines Level and Oxidative Stress Parameters in COVID-19",doi:"10.5772/intechopen.104950",signatures:"Marija Petrusevska, Emilija Atanasovska, Dragica Zendelovska, Aleksandar Eftimov and Katerina Spasovska",slug:"alteration-of-cytokines-level-and-oxidative-stress-parameters-in-covid-19",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}},{id:"81681",title:"Immunomodulatory Effects of a M2-Conditioned Medium (PRS® CK STORM): Theory on the Possible Complex Mechanism of Action through Anti-Inflammatory Modulation of the TLR System and the Purinergic System",doi:"10.5772/intechopen.104486",signatures:"Juan Pedro Lapuente",slug:"immunomodulatory-effects-of-a-m2-conditioned-medium-prs-ck-storm-theory-on-the-possible-complex-mech",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}}]},overviewPagePublishedBooks:{paginationCount:27,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science and Technology from the Department of Chemistry, National University of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013. She relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the National Institute of Fundamental Studies from April 2013 to October 2016. She was a senior lecturer on a temporary basis at the Department of Food Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is currently Deputy Principal of the Australian College of Business and Technology – Kandy Campus, Sri Lanka. She is also the Global Harmonization Initiative (GHI) Ambassador to Sri Lanka.",institutionString:"Australian College of Business & Technology",institution:null}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"7978",title:"Vitamin A",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7978.jpg",slug:"vitamin-a",publishedDate:"May 15th 2019",editedByType:"Edited by",bookSignature:"Leila Queiroz Zepka, Veridiana Vera de Rosso and Eduardo Jacob-Lopes",hash:"dad04a658ab9e3d851d23705980a688b",volumeInSeries:3,fullTitle:"Vitamin A",editors:[{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka",profilePictureURL:"https://mts.intechopen.com/storage/users/261969/images/system/261969.png",biography:"Prof. Dr. Leila Queiroz Zepka is currently an associate professor in the Department of Food Technology and Science, Federal University of Santa Maria, Brazil. She has more than fifteen years of teaching and research experience. She has published more than 550 scientific publications/communications, including 15 books, 50 book chapters, 100 original research papers, 380 research communications in national and international conferences, and 12 patents. She is a member of the editorial board of five journals and acts as a reviewer for several national and international journals. 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My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. 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He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. 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After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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David Pan",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSEI9QAO/Profile_Picture_1623656213532",institutionString:null,institution:{name:"University of Alabama in Huntsville",institutionURL:null,country:{name:"United States of America"}}},{id:"72920",title:"Prof.",name:"Yves",middleName:"Philippe",surname:"Rybarczyk",fullName:"Yves Rybarczyk",profilePictureURL:"https://mts.intechopen.com/storage/users/72920/images/system/72920.jpeg",institutionString:"Dalarna University, Faculty of Data and Information Sciences",institution:{name:"Dalarna University",institutionURL:null,country:{name:"Sweden"}}}]},{id:"27",title:"Multi-Agent Systems",keywords:"Collaborative Intelligence, Learning, Distributed Control System, Swarm Robotics, Decision Science, Software Engineering",scope:"Multi-agent systems are recognised as a state of the art field in Artificial Intelligence studies, which is popular due to the usefulness in facilitation capabilities to handle real-world problem-solving in a distributed fashion. The area covers many techniques that offer solutions to emerging problems in robotics and enterprise-level software systems. Collaborative intelligence is highly and effectively achieved with multi-agent systems. Areas of application include swarms of robots, flocks of UAVs, collaborative software management. Given the level of technological enhancements, the popularity of machine learning in use has opened a new chapter in multi-agent studies alongside the practical challenges and long-lasting collaboration issues in the field. It has increased the urgency and the need for further studies in this field. We welcome chapters presenting research on the many applications of multi-agent studies including, but not limited to, the following key areas: machine learning for multi-agent systems; modeling swarms robots and flocks of UAVs with multi-agent systems; decision science and multi-agent systems; software engineering for and with multi-agent systems; tools and technologies of multi-agent systems.",annualVolume:11423,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",editor:{id:"148497",title:"Dr.",name:"Mehmet",middleName:"Emin",surname:"Aydin",fullName:"Mehmet Aydin",profilePictureURL:"https://mts.intechopen.com/storage/users/148497/images/system/148497.jpg",institutionString:null,institution:{name:"University of the West of England",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"275140",title:"Dr.",name:"Dinh Hoa",middleName:null,surname:"Nguyen",fullName:"Dinh Hoa Nguyen",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRbnKQAS/Profile_Picture_1622204093453",institutionString:null,institution:{name:"Kyushu University",institutionURL:null,country:{name:"Japan"}}},{id:"20259",title:"Dr.",name:"Hongbin",middleName:null,surname:"Ma",fullName:"Hongbin Ma",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRhDJQA0/Profile_Picture_2022-05-02T08:25:21.jpg",institutionString:null,institution:{name:"Beijing Institute of Technology",institutionURL:null,country:{name:"China"}}},{id:"28640",title:"Prof.",name:"Yasushi",middleName:null,surname:"Kambayashi",fullName:"Yasushi Kambayashi",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYOQxQAO/Profile_Picture_1625660525470",institutionString:null,institution:{name:"Nippon Institute of Technology",institutionURL:null,country:{name:"Japan"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/57135",hash:"",query:{},params:{id:"57135"},fullPath:"/chapters/57135",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()