Risk factors suggested in the review papers.
\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"Milestone",originalUrl:"/media/original/124"}},components:[{type:"htmlEditorComponent",content:'
Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"760",leadTitle:null,fullTitle:"Ovarian Cancer - Basic Science Perspective",title:"Ovarian Cancer",subtitle:"Basic Science Perspective",reviewType:"peer-reviewed",abstract:"Worldwide, Ovarian carcinoma continues to be responsible for more deaths than all other gynecologic malignancies combined. International leaders in the field address the critical biologic and basic science issues relevant to the disease. The book details the molecular biological aspects of ovarian cancer. It provides molecular biology techniques of understanding this cancer. The techniques are designed to determine tumor genetics, expression, and protein function, and to elucidate the genetic mechanisms by which gene and immunotherapies may be perfected. It provides an analysis of current research into aspects of malignant transformation, growth control, and metastasis. A comprehensive spectrum of topics is covered providing up to date information on scientific discoveries and management considerations.",isbn:null,printIsbn:"978-953-307-812-0",pdfIsbn:"978-953-51-6640-5",doi:"10.5772/1268",price:139,priceEur:155,priceUsd:179,slug:"ovarian-cancer-basic-science-perspective",numberOfPages:420,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"48d061c2a2d650206b6407634887e116",bookSignature:"Samir A. 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Farghaly is a Physician / Scientist and national and international expert in Obstetrics and Gynecology at Joan and Sanford I. Weill College of Medicine and the New York Presbyterian Hospital / Weill Cornell Medical Center- Cornell University, New York, NY – USA. He received his M.D. from London University and his PhD degree in molecular biology from London University. He was affiliated with major London University teaching hospitals, Columbia University College of Physicians and Surgeons / Columbia University medical center, New York, NY-USA. He received several national and international clinical and research awards. He has been an invited speaker at several national and international conferences on Women’s health, Molecular genetic of female cancers, Gynecological cancer and oncologic radical surgical techniques. He is a member of several national and international societies, organizations, foundations of Women health and Cancer. He is the founder Editor-in Chief of Enliven: Challenges in Cancer Detection and Therapy Journal and The International Journal of Gynecological, Obstetrical and Reproductive Medicine Research. He acts as Senior Editor / Editor and member of editorial boards, editorial advisory boards of (18) international medical journals on Gynecological Cancers, Gene expression & Therapy, Women’s Health and Gynecology. He acted as guest editors of (3) special issues of international medical journals on oncology, gynecology and gene therapy. He is a reviewer for several medical journals on Obstetrics & Gynecology, molecular Genetics and therapy, Oncology, and Surgery. He has published 92 articles in reputed peer review journals. He has written several books chapters, and is an author and editor of (2) books on ovarian cancer published in 2012, and the third one published in Nov. 2013. The fourth book on endometrial cancer published in January 2015.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"3",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1066",title:"Gynecologic Oncology",slug:"obstetrics-and-gynecology-gynecologic-oncology"}],chapters:[{id:"28393",title:"Epidemiology and Etiology of Ovarian Cancer",doi:"10.5772/27679",slug:"epidemiology-and-etiology-of-ovarian-cancer",totalDownloads:4642,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Ana Fernández Montes, Jesús García Gómez, Miguel Nuñez Viejo, Miguel Alonso Bermejo, Susana Alonso Urrutia and Jesús García Mata",downloadPdfUrl:"/chapter/pdf-download/28393",previewPdfUrl:"/chapter/pdf-preview/28393",authors:[{id:"71077",title:"Dr.",name:"Jesús G.",surname:"Gómez",slug:"jesus-g.-gomez",fullName:"Jesús G. 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\r\n\r\n\tThis volume attempts to explore the practical aspects of econometrics to economics, and other social sciences that use econometric methods. This volume is expected to cover a broad range of topics that include but are not limited to spatial econometrics, time series, forecasting, and machine learning, This volume hopes to attract dynamic stochastic general equilibrium (DSGE) models which are gaining prominence in applied macroeconomics. This proposed volume could serve as a reference for academicians, researchers, policy-makers, graduate students, and very abled undergraduate students who are seeking current research on the various applications of econometrics as used in research and to answer specific policy questions.
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Working knowledge of MATHLAB and Dynare.\n\nResearch Fellow, Global Labor Organization (GLO), Oct.2017 to present\nAcademic and Professional Profiles \nResearch gate Profile:https: // www. researchgate. net/ profile/ Brian_ Sloboda\nORCID:https: // orcid. org/ 0000-0003-0007-1725\nGoogle Scholar Profile https: // scholar. google. com/ citations? user= RSLTrCsAAAAJ&hl= en\nEducation: Ph.D. Economics, Southern Illinois University at Carbondale,1997.\nThesis: The Economic Impact of Southern Illinois University on the State of Illinois: The Human Capital Approach\nM.S. Economics, Southern Illinois University at Carbondale,1992.\nB.A. Economics, Rowan University,1990.Minor: Mathematics.\nFields of Interest: Regional Economics, Economic Growth, Labor Economics, Economic and Statistical Education",institutionString:"University of Maryland, Global Campus",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"7",title:"Business, Management and Economics",slug:"business-management-and-economics"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"429339",firstName:"Jelena",lastName:"Vrdoljak",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/429339/images/20012_n.jpg",email:"jelena.v@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. 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Applications specifically designed for this purpose are widely implemented in a spectrum of medical and psychological conditions ranging from self-exam of blood pressure and heart rate through screening methods to identify depressive symptoms or assess the level of posttraumatic stress. Users of self-managing applications are not only more informed about their health-related conditions but also more empowered to act as an active role in the health care processes [9, 10]. In 2015, the Wall Street Journal pointed out the frequent implementation and the explicit benefits of self-managing applications in certain medical practices such as cardiovascular rehabilitation program and cancer pain management [11]. The advantage of utilizing self-managing applications in the medical and psychological care procedures is that these applications are more accessible and integrated to users’ everyday life experiences. They are often characterized by low cost, connectivity, anonymity, nonstop availability, and opportunities for a self-paced health care approach. For health care service providers, the versatile data gathered or reported from the applications facilitate better monitoring of the users’ health-related behaviors and are informative to further studies of the health conditions when compared and analyzed with data from a large group of users.
\nIn the context of bereavement, studies as early as in 2004 have demonstrated that more than half of the bereaved used online bereavement support, and such resources yield potential in preventing and protecting the bereaved from further mental disorders [12, 13, 14]. However, as Krysinska and Andriessen warned in one of their papers, most of the websites created by professional bereavement organizations are not immediately available or credited from the search, rendering the quality of online bereavement support and the authenticity of information under question [15].
\nAccordingly, this article takes a focus on designing a self-management application in bereavement-related contexts and presents the conceptualization and development procedures of it. We start by introducing the context of usage, followed by the process of conceptualizing two approaches to attend the needs in bereavement context. These two approaches were further prototyped into two applications, and one of which was selected for further development and evaluation. In the end, this paper reports a preliminary evaluation of the selected application and elaborates its potential to serve as both a data collection instrument in the future studies and a self-monitoring system for the bereavement process.
\nBereavement refers to an individual’s adaptive process following the loss of a loved one through death. The process is characterized by a variety of emotional responses (e.g., grief and distress) and cognitive crisis (e.g., meaning reconstruction), as well as heightened risk of syndromal medical conditioning and social and occupational impairment. It is also a fundamental and life-changing event that almost everyone will encounter in his or her lifetime. The prevalence and ubiquity of loss and grief are reflected in studies showing that most individuals will have experienced at least one loss by early adulthood (e.g., 60% have lost a friend; 81% have lost an extended family member; Herberman et al., 2013). Losing a loved one through death is frequently reported as one of the most stressful life events and was formally rated as the most stressful event in the Holmes and Rahe Stress Scale.
\nLooking from the other side of bereavement, it is a natural mechanism that helps individuals to gradually come to terms with the potentially overwhelming loss and to continue living a productive life in which the deceased is recognized in a different form of existence. The majority of bereaved coped with grief resiliently, and some of them even adopted so well that they further experienced enhanced meaning and spirituality post loss. However, a noteworthy percentage of bereaved, around 1 of 10 bereaved individuals, could experience a protracted and intense response to their grief referred to as prolonged grief disorder (PGD) [16].
\nIndividuals who suffer from PGD often feel “stuck” in the process of bereavement and find it hard to accommodate to a different lifestyle or the world without the deceased. PGD can severely hamper an individual’s psychological well-being, as well as the social functioning and physical health. In the extreme situation, individuals could experience strong suicidal tendency. For the individuals who suffer from PGD, psychotherapeutic intervention is mostly needed to support their adaptation and acceptance of the loss. On the other hand, performing grief counseling and therapy to normal grievers could yield deleterious effect and even disturb the natural bereavement procedure.
\nSince offering grief counseling to normal grievers is unwarranted, a screening method that helps to determine who will benefit from the psychotherapeutic intervention is of the primary importance. Psychologists have outlined the importance and pressing need of a trustworthy screening method, whereas the current PGD diagnosis instruments require a minimum 6 months to identify the PGD symptoms. The amount of time required to issue a PGD diagnosis and to allow psychotherapists’ active involvement is discrepant with the fact that individuals who suffer from intense grief or suicidality may need psychotherapeutic intervention in a more timely manner.
\nThe inability to identify potential PGD grievers in an earlier phase could also posit a negative implication on the development of preventive intervention and enhance the difficulty of attending the disorder after 6 months have elapsed. It could potentially explain why studies related to preventing PGD remained scarce and the effect far from warranted.
\nAssessing symptomatology and attending to the needs of grievers with severe emotional distress as quickly as possible is imperative. Various approaches were explored by previous bereavement-related studies to identify problematic self-evaluations and potentially traumatic characteristics that contribute to predicting poor adjustment outcomes to bereavement. These approaches can be briefly categorized into two groups.
\nThe first group stems from the problematic narratives and coping strategies can potentially be detected through linguistic cues or behaviors post loss [17, 18, 19, 20]. Examples of the first approach include negative self-evaluation such as thinking that the self is less worthy without the deceased and problematic coping strategies such as repetitive rumination of the deceased. The second group evaluates the traumatic loss circumstances and psychological states that can make the bereaved vulnerable to poor adaptation, all of which are often static at the time of loss and are harder to change [21, 22, 23, 24, 25, 26, 27, 28, 29]. Examples of the second approach range from traumatic death, lacking social support to the strong dependency on the deceased and an insecure attachment style.
\nBoth approaches are informative for follow-up development of screening methods that could support grievers and psychotherapists to monitor the bereaved’s susceptibility to PGD and to target the appropriate interventions in a more timely manner. A primary concern is that these methods remain in a highly theoretical and explorative phase and are in demand of empirical validation. In this regard, the applications developed should also serve as a means of evaluating and validating the proposed screening approaches. With this concept in mind, we propose two Internet-based applications that seek to empower the bereaved by providing meaningful feedback to the aspects related to their grief experiences and, on the other hand, collect useful data that contribute to further validation of the screening methods.
\nTwo prototypes were developed using different approaches. The first prototype, My Grief Journal, was a technology-driven concept based on the available technological solutions and studying the related bereavement literature. The second prototype, Grief Inquiry Following Trauma, was developed with field experts and psychotherapists. The overall aim of both applications is to empower the users to gain knowledge and control of their bereavement-related decisions. To achieve this goal, the research team defined the following concepts that should be achieved by both prototypes:
\nTarget users: individuals who have experienced death of a loved one and would be interested in searching for support on the Internet, especially individuals who have experienced the loss very recently or less than 6 months ago.
Deliverables: an Internet-based Product Service System (PSS) that provides meaningful, objective, trustworthy, and quantitative feedback of the various bereavement-related aspects.
Portal: the application should be affordable, easy-to-use, and widely accessible through the computer and mobile devices.
The system must collect only bereavement-related data from the users and generate personalized feedback based on the data collected.
The feedback provided to the users must contain both positive and negative aspects of their grief situation and must come from the authentic sources.
The prototypes should attempt to integrate and utilize the existing and validated measures as a starting point but should remain flexible for developing and validating new measures.
Although the purpose of this project was not to develop an intervention of PCBD, due to the sensitive nature of loss and grief study, the team included one researcher specified on bereavement and post-loss meaning reconstruction and one psychotherapist specified on grief counseling. The external experts brought contribution to the design and phrasing of questions that were used in assessing the grievers’ grief experiences and provided further opinions from psychological field on the ethics and design of the study. The author, as a lead investigator of this study, first proposed two prototype concepts based on previous literature review for evaluation within the team, and the final decision was made based on the practicality of the concept and the available technology that could facilitate the prototyping of the app.
\nBased on the suggestion of the IRB, to pilot test the app and gain users feedback from the concept, the team had recruited a certified thanatologist and grief counselor to facilitate the session. It was meant to avoid bias in interviewing the users and to maintain anonymity of the study. An interview protocol was drafted by the researcher and the psychotherapist to ensure the questions would not provoke excessive/harmful emotional responses. The interview was conducted in English, and all of the users were native English speakers.
\nThe concept of My Grief Journal was inspired by studies concerning the self-narratives in the bereavement process and the meaning reconstruction theory. Narrative variables can be effective predictors of psychological health during bereavement and even of the outcome of coping with bereavement. Counting the relevant words in the written text was considered an effective approach to measuring the cognitive changes and emotional expression in the bereavement context. Many suggested endorsed that verbal materials carry more additional information about psychological phenomena and symptoms, which are often less detectable from self-report [19, 30]. For instance, consider the following two examples, “it’s so hard to say good bye” and “I am lucky to have somebody that makes saying goodbye so hard.” Both sentences included a negative statement but were framed in a different manner and hence reflected different appraisal to an event.
\nThe researchers tested various available types of software and APIs to perform the keywords extraction and analysis and determine the positive emotions and negative emotions in the narratives. We used a narrative that described feelings in an indirect manner. For instance, “I am feeling terribly good today,” or “…determined to enjoy her luxury of grief uncomforted.” It was easy for human to understand but hard for programs to determine whether the sentence really described a positive perception or a negative one. The most precise software appeared to be Linguistic Inquiry and Word Count (LIWC). However, it was not available in command line interface (CLI) and the EULA prevented users from implementing it in a customized application. Other alternatives tested were NLTK in python, Afinn, and AlchemyAPI. In the end, IBM Alchemy API was implemented to extract meta-data such as concepts, entities, keywords, categories, sentiment, emotion, relations, and semantic roles. Unfortunately, there was no corpus specifically trained for bereavement-related sentences or articles. Therefore, it could not be as precise as the corpus for movie reviews, tweets, or advertisement.
\nMy Grief Journal was developed to store users’ short articles (e.g., diaries) and analyze the sentiment of the article. The analysis will yield two types of results, providing a visualized feedback of the frequency of the emotional keywords detected in the article and determining the positive or negative valence of the keyword and its relationship to five types of emotions (anger, disgust, fear, joy and sadness). Figures 1 and 2 showed the sample page and report of My Grief Journal. Unfortunately so far, there was no available corpus specifically trained for bereavement-related sentences or articles. Therefore, it could not be as precise as the corpus for movie reviews, tweets, or advertisement, which was an obvious drawback that obstructs the researchers from testing it with grievers. Only the developers and the research team members tested it. Developing My Grief Journal should include training the corpus with plenty of bereavement-related articles or sentences in order to determine how to precisely analyze the sentiment in the users’ writing.
\nThe entry page of My Grief Journal.
The demo visualization of keywords and the valence of the keywords.
The concept of GIFT stemmed from psychological studies related to prospective risk factors that could render grievers more vulnerable to PGD, such as low social support, low income, or traumatic death circumstances. A framework of risk factors was created based on literature review (see Table 1).
\nRisk factors | \nPrimary or potential risk factor | \nDetails | \n
---|---|---|
Social support level | \nPrimary | \nLacking social support is a salient risk factor that is highly related to problematic grief | \n
Discovering the body | \nPrimary | \nDiscovering the body or viewing the death scene (especially with traumatic nature) is a salient risk factor for PGD | \n
Satisfaction with the death notification | \nPrimary | \nDissatisfaction with death notification | \n
Pre-death dependency | \nPrimary | \nHigh levels of pre-death marital dependency | \n
Attachment style | \nPrimary | \nAvoidant/anxious/insecure attachment style | \n
Close kinship | \nPrimary | \nBeing a spouse or a parent of the deceased | \n
Gender | \nPotential | \nFemale grievers are more susceptible to PGD than male grievers | \n
Ethnicity | \nPotential | \nBeing non-Caucasian is regarded as a risk factor for PGD | \n
Educational level | \nPotential | \nLow education is connected to having more severe grief | \n
Income level | \nPotential | \nInsufficient income | \n
Type of loss | \nPotential | \nLosing a child of any age to a violent sudden death | \n
Anticipation of grief | \nPotential | \nDeath is unexpected | \n
Prior losses | \nPotential | \nPrior losses | \n
Risk factors suggested in the review papers.
All of the risk factors were reviewed by the researcher and the external experts [21, 24]. Two measurement tools were designed together by the researcher and the external experts in order to measure the risk factors. The team has further included another to-be-validated scale for identifying risk factors related to bereavement and loss circumstances. These three questionnaires were grouped into the major section, Basic Information. Basic Information consisted of questionnaires related to the participant’s demographic characteristics and proposed predictors of bereavement distress (Table 1; scales #1–3). Six validated questionnaires were selected to provide feedback on bereavement-related perspectives. They measured respectively grief degree (PG-13), depression (CESD-R), post-traumatic stress disorder (PCL), resilience (CD-RISC-10), meaning making (ISLES-SF), post-traumatic growth (PTGI). These six questionnaires belonged to the secondary section named Monitor My Grief. Table 2 displayed a list of scales included in the application. The validated scales administered were, if not openly available, all requested or purchased from the respective researchers and consent acquired to use in the app.
\nScale set | \nScale name | \nTo assess | \n
---|---|---|
Basic information (including loss-related characteristics) | \n1. Background information | \nDemographic data, such as age, gender, ethnicity, religious affiliation | \n
2. Complicated grief risk factors checklist (CGRF) | \nProposed predictors of bereavement distress | \n|
3. Bereavement Risk Inventory and Screening Questionnaire (for the bereaved; BRISQ-B) | \nRisk factors of Prolonged Grief | \n|
Monitor My Grief | \n4. PG-13 | \nGrief severity | \n
5. PCL | \nPosttraumatic stress | \n|
6. CESD-R | \nDepression | \n|
7. CD-RISC-10 | \nResilience | \n|
8. ISLES-SF | \nMeaning made of loss | \n|
9. PTGI | \nPosttraumatic growth | \n
Assessment instruments.
Scales #1–3 assess bereavement-related risk factors. Scales #4–9 have been empirically validated and are widely used in bereavement research.
The feedback that addressed the participants’ result after taking the questionnaire was drafted for the six validated questionnaires in the Monitor My Grief section. Users who successfully completed the questionnaire will be presented a personalized feedback according to the score of each validated questionnaire. It was meant to adhere to the purpose of design of GIFT and to lessen participants’ stress after taking the emotionally disruptive questionnaires.
\nPersonalize the questionnaire with the name of the deceased. An important feature for GIFT was that all of the questions were personalized with the name and gender of the deceased (replace “the deceased” or “the person I lost” into the name of the deceased) to engage the users.
\nSlider selection for Likert scale questions. Most of the Likert scale options were displayed in a horizontal slider to enhance the linear relationship of the options (see Figure 6 for an example). The handle will change color after an answer has been indicated (see Figure 7 for an example). When users access GIFT on a mobile, we choose to keep the two items in the left and right of a Likert scale question but allow users to review the default value after hovering or clicking on the pip on the slider (see Figure 8).
\nAdd the option “not applicable” to the risk factor questionnaires. For scale #2 and scale #3, users were provided “not applicable” on the right of all of the questions. This was to allow them to better express themselves when the presented risk circumstances appeared not applicable to them and the options failed to help them to convey it (see Figure 9).
\nAccording to the IRB suggestion, the website was certified by SSL protocol protection, and all of the data collected in GIFT were coded and encrypted in order to ensure the security of the data.
\nThe research team evaluated both applications regarding the opportunities to yield trustworthy and quantifiable predictions in the earliest phase of bereavement. In comparison to My Grief Journal, which required a period of contemplation and was less precise in determining the positive and negative thinking style, GIFT exhibited better potential to offer users meaningful and objective feedback based on evaluating the factors that are relatively static and foreseeable even before the loss (Figures 3 and 4).
\nGIFT entry page.
GIFT slider scale.
In the end, GIFT was selected for further development and implementation to validate the proposed risk factors with a larger base of participants. To gauge the applicability of the app in the real life situation and optimize the user experiences of using it, five sessions of protocol analysis were conducted in the United States with the patients of one of the collaborative psychotherapists. The approval to conduct the study with the bereaved patients and to deploy the application through the Internet was sought in the respective Institutional Review Boards from both United States and the Netherlands, in which the former is where the study will be conducted and the latter is where the app was conceptualized and developed (Figures 5–9).
\nGift personalized report.
A slider for Likert scale answer.
Slider response after an answer is indicated.
The responsive slider on a mobile device.
When user selects “N/A,” it means that the statement could not apply to his/her situation.
In the protocol analysis session, participants were prompted to “think out loud” on an individual basis as they completed the questionnaires by a certified thanatologist, who is also a graduating counseling student. After completion of the scales, participants were interviewed with questions regarding their general experiences of using GIFT, the wordings of the application as well as of the personalized feedback they received after completing the scales from the second section (Monitor My Grief). The protocol analysis sessions were all audio recorded and completely transcribed. Each session was approximately 1.5 hour long, generating approximately 7.5 hours of recording from the interview and the notes from the interviewer.
\nThe protocol analysis sessions for GIFT pilot testing were all audio recorded and completely transcribed. Each session was approximately 1.5 hour long, generating approximately 7.5 hours of recording from the interview and the notes from the interviewer. All of the participants were from the United States. There were total five participants, including one male and four female grievers. Their socio-demographic data are displayed in Table 3. Almost all of the participants bereaved about the loss of a family member. Of the total, 80% have received formal education for more than 13 years and had their religion. Participants who considered religion important practiced religious activity more frequently. Except PA3, who experienced death of a loved one around 6 months ago, the other participants generally experienced death of a loved one for more than 6 months to receive psychotherapeutic support. Two of our participants experienced unnatural death of a loved one such as suicide or fatal accident, and 60% of our participants were in contact with the deceased almost daily before the death happened.
\nParticipant | \nPA1 | \nPA2 | \nPA3 | \nPA4 | \nPA5 | \n
---|---|---|---|---|---|
Gender of the participant | \nFemale | \nFemale | \nFemale | \nMale | \nFemale | \n
Gender of the deceased | \nMale | \nMale | \nMale | \nMale | \nFemale | \n
Age of the participant | \n70 | \n39 | \n32 | \n61 | \n31 | \n
Age of the deceased | \n70 | \n26 | \n40 | \n87 | \n95 | \n
Relation to the deceased | \nSpouse | \nSister | \nPartner/fiancé | \nSon | \nGranddaughter | \n
Marital status | \nWidowed | \nMarried or living together in a committed relationship | \nSingle | \nMarried or living together in a committed relationship | \nSingle | \n
Years of formal education | \n17–20 years | \n0–8 years | \n13–14 years | \n17–20 years | \n15–16 years | \n
Faith tradition (religious belief) | \nChristianity | \nChristianity | \nAtheism | \nChristianity | \nBuddhism | \n
Regularity of religious activities | \nDaily | \nAt least once per week | \nNever | \nAt least twice per week | \nAt least twice per year | \n
Importance of faith | \nExtremely important | \nExtremely important | \nNot very important | \nVery important | \nSomewhat important | \n
Prior experiences of death of loved ones in the past 3 years | \n3 | \n0 | \n0 | \n1 | \n2 | \n
Time since the loved one died | \n1 year and 4 months | \n1 year and 9 months | \n6 months | \n1 year and 4 months | \n11 months | \n
Type of death | \nNatural anticipated death | \nFatal accident | \nSuicide | \nNatural sudden death | \nNatural sudden death | \n
For how long did the participant know the deceased | \n46 years | \n26 years | \n3 years | \n60 years | \n31 years | \n
The frequency of contact before death | \n2–7 times per week | \n2–7 times per week | \n2–7 times per week | \nEvery other week | \nLess often than once per month | \n
The socio-demographic data of the protocol analysis participants.
The preliminary test of GIFT yielded fruitful data for future optimization. Since the three questionnaires from the background information were still under development, and the details of wordings and content refinement would not be of interest to the readers of this article, this discussion concentrated on the general experiences of using the app and participants’ feedback on the applicability of this app in their bereavement process.
\nAll of the participants were under bereavement intervention by professional therapist and trusted that they need professional counseling. We were particularly interested in participants’ support seeking on the Internet, since this app was developed as an Internet-based app. Three out of five participants reported having searched for information related to bereavement or grief support on the Internet. One participant did not answer, and one indicated that she had never thought of searching for support on the Internet. The information on the Internet helped them to gauge their grief level or target the therapies that were available/appropriate for them. One participant specifically stated that reading other people’s stories about surviving traumatic loss was helpful. Another participant indicated that grief is too personal and looking for support on the Internet did not feel safe.
\nIn general, Internet sites, blogs, and forums were resources that participants could turn to when they needed immediate answer to their questions or information related to grief counseling or coping strategies. However, it was still obvious that participants were mostly prone to find a therapists or “somebody” who knows grief to support them, implying that bereavement-related services or information on the Internet, disregarding the quality of it, could face the difficulty to gain trust from the users. It could also be because most of our participants knew that they needed psychotherapeutic support at the first hand and only used the Internet to help them gain access to the services.
\nMost of the participants were satisfied with GIFT and found the feedback relevant, authentic, and reflective to their real situation and trustworthy. Some positive feedback pieces were as follows:
\nGIFT was a tool for thinking and widens awareness of the bereavement-related aspects.
GIFT was a tool that enhance self-referring from grievers who obviously need grief counseling
Personalizing the questionnaires with the name of the deceased was really immersive, love it.
The process of using GIFT was therapeutic.
The feedback was trustworthy and reassuring.
The questionnaire results were similar to what the participant thought about herself, but it was more validating.
Some negative feedback pieces and suggestions were also reported:
\nThe session took too long to complete, and the data should be saved step by step.
The feedback only presented shallow and “canned” responses to the questionnaires result.
It should connect to useful resources in the end of the feedback (e.g., books, grief counselors).
The fifth participant encountered enormous technical difficulties because of older version of hardware.
Participants should be “guided” through the process instead of choosing what questionnaires they should do next. The navigation had to be more clear and straightforward.
The application should allow participants to share the results with others (e.g., sending the report to their family or friends).
The slider scale required some time to get used to, but participants grew accustomed to it after several questions.
The instructions of the questionnaires needed to be highlighted and emphasized so participants would not oversee them.
Based on the participants’ feedback, there were several points to take into consideration for next stage app refinement.
\nThe problem of various usage platform: GIFT was a Web application, and we tested it with different devices such as computer, tablet, and mobile phone. One participant was using an iPhone 5S, and the questions and answers were completely overlapped. The problem could be caused by the older version of browser that did not support libraries such as jQuery. Designers usually need to take into consideration of how much the application was backward compatible and make a clear suggestion to the users.
\nThe difference between mobile navigation and large screen navigation: on the larger screen, the questionnaire were separated into two groups and placed horizontally within each group. This design generated confusion for the participants who used tablet or laptop. One the mobile devices, the blocks were naturally sorted from top to bottom and participants who used mobile devices did not have problems related to navigation.
\nThe app should add a function to share the report with other people.
\nFormat of date: In the U.S., it would make more sense if the date was formatted as “month/day/year.” In this question, we provided a date picker powered by jQuery. However, it should be noted that the date format had to accustom to the familiar format of the participants.
\nThere should be a save button where participants can review the in-progress questionnaires. This feature was added later on.
\nThe environment of using this app should be suggested in the welcoming message. One participant mentioned that she would not be able to complete the questionnaires at home with her kids, suggesting that participant would appreciate a certain period of engagement in the app.
\nThe app will welcome the users with a note of how long they could expect to complete the app in one session. In the introduction of each questionnaire, we should also indicate a time range of how long users usually take to complete the questionnaire.
\nKeywords such as “in the past month” in some questionnaires should be enlarged/bold and highlighted with visible colors. Some of the questionnaires such as PTSD or CESD-R were designed specifically to inquire the participants’ experiences in the past months or past weeks. These keywords should be stressed since without emphasizing these conditions, the whole questionnaire could not precisely measure the participants’ experiences.
\nThe sliders in the questionnaires were nice, but there should be instructions of how to operate the sliders and the default option needed to be considered with caution. Some of the questionnaires were designed with Likert scale responses. Since the items in a Likert scale usually had a linear relationship between each other, it was a conscious choice of the research team to use a horizontal slider that allowed users to slide between each “pip” on the bar. However, researchers need to be very cautious in choosing where to place the default option or not to place it. In the study, the default option was placed in the 3rd Likert scale item. For instance from “Strongly disagree” to “Strongly agree,” the default option was placed in the middle “Neither agree nor disagree.” However, when the participants had the same answer with the default value, they simply skipped this question and realized that they needed to click or slide on the slider when trying to submit the questionnaire. It is important to provide certain instruction at the beginning that informs users how to interact with the slider
\nIt should be explicit that the question has been answered, and the participants should be able to review their answers.
\nDisregarding the obvious need to enhance the navigation and user experiences of the application, from the preliminary test, we could conclude that GIFT exhibits a good potential to be implemented in the early phase of bereavement and could empower the bereaved to be more attentive and autonomous to their grief response. Alone with the design of the application, a study was also planned to test GIFT with a larger base of participants and collect data that could be informative to validate the risk factors of PGD empirically. Modern technologies are more and more interwoven into our everyday life experiences. Grief was, and maybe still is, a highly private experience, but contemporary researchers have notified a growing phenomenon of bereaved individuals seeking social support and sharing their grief experiences or emotions on the Internet. Furthermore, the Internet likely also serves as a medium of communicating and connecting with the deceased. Examples are frequent addressing the deceased in a post on social media or talking to the deceased in a public forum. The effect of these phenomena remains unknown in both an intra- and interpersonal level but is by far worth heeding. More studies are being planned and will be presented elsewhere. We hope more results from the future studies can contribute to informing the field and professional practitioners how to better support the bereaved and facilitate positive health outcomes following the coping process of the bereavement.
\nThis work is funded by the Taiwanese Ministry of Education Funds for Studying Abroad. The authors want to thank Taiwanese government for sponsoring the study and Ph.D. project.
\nThe authors also wish to address deepest gratitude to Laura Nelson for her professional execution in the protocol analysis sessions and to all the participants that contribute precious opinions regarding the contents and user experiences of the app.
\nRadiopharmaceuticals were first defined by the Federal Register of the USA as radioactive agents- potassium (40K) and carbon (14C) based natural compounds- or biological products contain unstable nuclei which may degrade spontaneously and emit photons or nuclear particles. These drugs might be prepared using nuclide generator or nonradioactive reagent [1].
Radiopharmaceuticals are categorized into 4 main classes: research, diagnostic, environmental and therapeutic pharmaceuticals as presented in Figure 1. Research radiopharmaceuticals are administrated to track metabolic reactions and kinetics including bio-distribution, bioavailability, pharmacokinetic, and pharmakodynamic of a drug that is intended to be used later as nonradioactive form [1].
Radiopharmaceutical applications in diagnosis, therapeutic, monitoring environment, and new trends in research.
Diagnostic radiopharmaceuticals Known as radioactive drugs/ompoundsc which used tracers for many diseases. Using gamma-ray emissions from radiopharmaceuticals drugs would help on broadcasting their positions inside the body. The concentrations of the radioactive materials could be deduced by observing these broadcasts in several organs. Images of different organs with low-resolution could be obtained using the signals [2].
The pharmacodynamics -the metabolism of the drug inside the body- and the kinetics could be studies by monitoring these broadcasts in a time-dependent manner. The device of monitoring is a collimated external gamma-ray detector. Therefore, in diagnosis purposes the radioactive materials are used to detect any sort of molecular, biochemical, physiological, and even anatomical abnormalities.
However, the diagnostic radioactive materials are not limited to gamma emitters types which allow their
There are many variant body samples and fluids could be considered as well such as urine, blood, and biopsies samples in specific conditions.
Therapeutic radiopharmaceuticals are radioactive substance which could help in delivering the radiation entirely of body tissues by administration to radioactive substances such as iodide I3I for thyroid removal in hyperthyroidism patients. The thyroid organ is irradiated entirely by radioactive iodine. Other different radiopharmaceutical materials could be used in treatment of cancer and known as radiotherapy [1].
Although training on the use and management of labeled compounds is provided in various institutions, the demand for pharmacists who specialize in radiolabeled drugs has been determined, and radiopharmaceuticals have become the first specialty in the late 1960 in Pharmacy school at the U. of Southern California (USC), USA. The short-term research courses (usually 30 days for non-graduate students) and the radiopharmaceutical technician training program conducted from 1969 to 1986 enabled 201 pharmacists and other personnel to obtain a master’s degree in radiopharmaceuticals, and 15 of them obtained technology Certificate, and more than 500 people have participated and provide such expert training elsewhere and completed its plan in 1986 [3].
Clinical needs can be in image performances which may have a vital role either in staging or prognosis of the disease. Long ago, several programs that are educational and anxious with radiopharmaceutical analysis have not addressed this question. The program is frequently specialize in labeling a particular compound and on its application without any thoughts for its potential application in future. Even once a specific biological target is being targeted, the question of whether or not it addresses a true clinical would like is usually not considered [4]. The usage of radiolabeled organism antibodies for imaging a neoplasm is taken into account a decent example. On the last decades, a great deal of studies were on developing programs based on aforesaid materials and this terminated and resulted in radiopharmaceuticals that may image cancer effectively and thought of as highly sensitive and specific methodology for imaging comparable or superior to other techniques.
Most important modifications in health care in west were in the 1990’s. At this time, many resources became unrestricted in conjunction with complete clinical freedom and open-ended budgets this led to high level of control for health-care requirements with limited budgets, established protocols, and internal markets. The development of drug has regulated as well. Radiopharmaceuticals considered as one of the regulators which regulate conventional drugs which in turn increase the costs for the development of these drugs.
The academic discoveries in commercial development of radiopharmaceuticals were limited due to limitation in radiopharmaceutical industry and many vicissitudes in the institutions carrying out development in this field.
National nuclear centers whole over the world faced a lot of obstacles such as being privatized or being overburdened to make commercial gains. Academic funding for scientific research has also been cut off for long periods at universities. The academic curiosity was one of many reasons for scientists to put radiopharmaceutical field in the scope of research. To gain success in this field, projects should be developed, more directed, productive, and focused than was required earlier. Particularly, developing the clinical application of the product must be taken in consideration combined with the overcoming the financial obstacles. Therefore, unique new radiopharmaceuticals must fulfill a clinical requirement [5].
Many new therapies in clinical practice have other requirements, such as managed care plans and expensive restrictions. This represents both an opportunity and a challenge for new radiopharmaceuticals [6]. It is necessary to maintain a reputation for safety and efficacy, and to improve existing treatments for any new products. In such a restrictive environment, it will be difficult to find a place in the market for radioactive compounds of these new drugs in clinical practice. Another way to introduce new and expensive treatments is to determine the subset of patients most likely to benefit from that particular treatment. The unique advantage of medicine is that it has the ability to combine diagnostic and therapeutic radionuclides for the same purpose, and may remain unchanged. In the future, diagnostic and therapeutic radiopharmaceutical pairs will increasingly be used to perform this function [6]. At the scientific level, radiopharmaceutical research has undergone a process of substitution in recent years. This review of compounds which describes certain aspects of current radiopharmaceutical research that have appeared in recently published literature or have become the subject of conference presentations [7]. Some of these issues are also the subject of more detailed review. However, this chapter deliberately excludes certain subject areas, especially not trying to cover developments in the field of positron emission tomography [7].
Radiopharmaceuticals are the cornerstone of nuclear medicine. Although there are many types of drugs that can study the structure and function of many essential organs, there is still a need for radiopharmaceutical substitution to study the subtle mechanisms of human body function. Under this trend, I5O, I8F and 123I appeared in the throttle body. With the emergence of such radionuclide-labeled drugs, especially the most widely used 99mTc, people are also doing their best to translate this success into daily clinical practice. β-labeled drugs can also be used for targeted radiotherapy of various malignant tumors. In addition to laboratories in industrialized countries, some developing countries have also shown interest in these fields and participated in research projects [8].
Therapeutic radiopharmaceuticals have a critical effect on patient care specifically on medicine which have a promising role in the future. Many of latest therapies in clinical practice in need of different requirements like managed care programs, restrictions which are expensive. This symbolizes both a chance and a challenge for brand spanking new radiopharmaceuticals [6]. Efficacy and safety are among many others advantages to be added over the current treatments for any new product. Therefore, in such a restrictive environment there’ll be an issue for these new medicinal radio compounds to urge their place within the routine of clinical practice. Though, another route to abide with the new protocols is to define which group of patients may benefit from this special treatment. The strength of nuclear medicine is its capability to merge the uses of radionuclides in both diagnostic and therapeutic purposes for matching targets in diagnostic and therapeutic radiopharmaceuticals [6].
This chapter describes, generally terms, some aspects of current radiopharmaceutical research which have appeared within the recent published literature or are the topic of conference presentations [7]. Several of these topics are also the subject of more detailed reviews during this publication. However, some specialized areas of labor are deliberately excluded from this chapter, especially, no attempt is formed to hide developments within the field of Positron Emitting Tomography [7].
Radiopharmaceuticals form the cornerstone of nuclear medicine. While the existing range of radiopharmaceuticals permits study of the structure and function of many important organs, there is a need for new radiopharmaceuticals that could be used to explore more subtle mechanisms of bodily functions. Important progress has been achieved in this direction by the development of tracers labeled with cyclotron produced isotopes, including UC, 13 N, I5O, I8F and 123
Nowadays, most of research in the area radiopharmaceutical is focusing on the tracers of receptor binding in biochemical reactions. The nature of these reactions may be Intra-extracellular in nature and may exhibit a good progress in tissue characterization using imaging technique in-vivo. Several of these agents are depending upon wide range of size; large MoAbs to tiny peptides (e.g. neuropeptide) which utilize bifunctional chelating agents to radiolabeling drugs/compounds. Radiopharmaceuticals of polypeptide may be in the brain whereas low molecular weight molecules retained high lipophilic characters to interact intercellular are highly needed (e.g. cell-surface receptors). Radiopharmaceutical chemists are facing many challenges to synthesis these compounds via one of two methods; namely integrated method or pendant method to utilize technetium coordination with interest on technetium (v) cores. Malignancy, neurology, inflammation, neurology, and infectious diseases are among many other health disorders which are in dire need of cytotoxic radionuclides in the area of radioimmunotherapy. This may prompt researchers to focus their research and the newly developed radiopharmaceuticals toward specific clinical and biological targets [9].
Emerging MoAbs associated with radionuclide(s) to target selective Tumors (antigens) may considered as an early research took place using iodine radionuclides in cancer. Moreover, some of these drugs/compounds are targeting the outer surface of cells, others may interact with the inner surface of the targeted cells. There are many examples for applications of different radiopharmaceutical in diverse therapeutic applications, e.g. nucleosides and their analogues in modulation of both cell proliferation as well as mRNA transcription. Besides imaging of cell proliferation and mRNA transcription, a good advancement had been made to articulate a sort of tracers for imaging cell hypoxia. Interestingly, the progress in radiolabeled agents may exhibit remarkable benefits for speculating the resulted outcomes of tumors to radiotherapy beam which is greatly affected by the potential oxygen of the cell as in cardiac hypoxia. Discovery and search for new radiolpharmaceutical with new therapeutic applications revealed by chance non-nitroimidazole technetium-labeled molecule during a research program at Amersham International which is also trapped by reduction in hypoxic cells and this new agent is currently in the final stage of drug approval. Several therapy applications are summarized in the next section [7].
This area has provided a rich field for radiopharmaceutical research in last few years. Many of the newly developed radiopharmaceuticals products are derived from peptides, antibodies, cytokines, and polypeptides and very much similar to the ones which have been used in cancer [7].
The capability to image the indirect or direct inflammatory response to the infection is the key for clinical management with high selectivity, e.g. Antibiotic complex of Technetium (Ciprofloxacin = Tcinfecton “Tc”) [8]. Tc is good for labeling leucocytes to hammer Tc-leucocytes to place of infection. Several other examples, Tc-HMPAO, Tc-ECD, Tc-citrate, and Tc-glutathione etc. All of these Tcs proved to be concentrated in some tumor and/or inflammatory sites. Moreover, other complexes for imaging inflammation, e.g. human immunoglobulin Gb and 99Tcm “HIgG-99Tcm” is an interesting serendipity drug developed from the reduction of disulphides (-S-S-) under very mild conditions to produce free –SH groups. The efficacy of the formed labeled chemotactic complexes act as substrate(s) for imaging infection
HPLC analysis showed that the efficacy of the radiolabeled Tcm-Ciprofloxacin is over 95%. Meanwhile,
Molecular biology plays a crucial role in identifying many receptors and sub-type receptors for neurotransmitters. Subsequently, this encourages radiopharmaceutical industry to conduct neuroreceptors brain imaging as is one of the major application of the radiopharmaceutical research [7].
A true replacement to hippuran-123I has been a challenging task in the development of technetium complexes, as no Tc compound is completely extracted and secreted into urine. It has, however, been possible to develop compounds which are handled by the renal tubules and actively secreted into urine. Structural feature requirements for recognition by renal tubules and for delivery by serum protein bound transport propounded way back by Despopoulos, [-C(=O)-NH-CH2-COOH], have been sought in the technetium complexes to achieve some degree of success. For most clinical purposes, a renogram agent based on renal tubular handling would be very much more useful, apart from being superior to purely GFR based agent such as 99Tcm -DTP A, and hence the intense research efforts. Tc-MAG3 complex contains the structure referred to above, while Tc-EC has a structural mimic, 3 oxygen atoms at 3–4 A0 to one another in Tc(=O)-NH-CH2-COOH, cf. -C(=O)-NH-CH2-COOH [9]. Both Tc-MAG3 and Tc-EC show less excretion than hippuran, but Tc-EC has relatively superior features. The room temperature formulation recipe of Tc-EC is another practical advantage. The early apprehensions of differences in the purity of kit formulated and chromatographically purified product were removed with refinements in kit formulation procedures. However, due to inherent nature of possible trace impurities in MAGS synthesis as well as different types of TcMAG3 complexes feasible, interference from hepatobiliary involvement during renography studies has not been ruled out. One study is in fact devoted to the anomalies in Tc-MAG3 behavior, Modifications to MAG3 ligands to overcome the drawbacks have been sought, replacing glycine by another amino acid, introduction of chiral center to influence the stereochemical role etc.; some superior results have been achieved, like 99Tcm -D-MAGAG. Tc-L, L-EC requires to be prepared at highly alkaline pH of 11–12 and it is consequently difficult to present in a reliable single component lyophilized kit form, though a commercial kit has been cited in literature. Detailed stringent protocol for kit formulation has been suggested. A multi-component kit recipe would be generally necessary, but advantage of ease of transchelation (using GHA) based kit has also been reported. As discussed earlier, the development of Tc-EC for renal tubular function, is an outcome based on the excretory pattern of Tc-ECD and the study of its metabolite(s) [12]. The attempts to utilize cysteine, cystine and analogues for complexing technetium for obtaining renal agents had shown mixed findings, but the same group from India has recently demonstrated a new product for renal tubular function imaging. 99Tcm complex of dimethyl ester of DTPA denoted as Tc-DMDTPA, has shown promising results including in human volunteers. Analogous to Tc-DTPA, the Tc-DMDTPA complex is anionic, but has predictably less (−50%) electrophoretic mobility. Ease of reliable, stable, single component lyophilized kit formulation, room temperature preparation of Tc-DMDTPA in high yield, purity and stability and similarity in biological behavior to hippuran- l j lI and Tc-MAG3 in both normal and probenecid (renal tubular transport inhibitor) treated mice are the salient advantages reported. A cationic pathway renal tubular agent has also been reported from UK involving the complex of 1,2-diaminocyclohexane (DACH). The product, [Tc(V)02(DACH)2]”, is formulated using stannous tartrate reduction of pertechnetate and has shown utility for eliciting renal tubular function, when anionic pathway is not freely accessible due to high concentrations of circulating anions, like during chemotherapy [9, 12].
In the genesis of the growth of 99Tcm compounds, the introduction of DTPA chelate of technetium, use of stannous tin for reduction of Tc (VTT) in pertechnetate and lyophilization of premixed stannous tin - ligand formulation would merit the first mention despite the passage of time. Suitable variation(s) in the functional groups on the ligand backbone to influence the pharmaco-kinetic behavior of the resultant technetium complexes, while retaining the same chelating environment for technetium, was a major development. This eventually led to introduction of the most preferred hepatobiliary tracer, 99Tcm-mebrofenin [2]. Such systematic investigations of structure - activity distribution relation (SADR) provided a fresh approach for the development of many other new products. The concept of bifunctional nature of ligands was also propounded after this work, for in LID As, IDA groups participate in complexing technetium, while the phenylcarbamoyl moiety bestows some of the required biological features. Although in the present sense of the term BCA, this may not be strictly correct, the way was paved for a new approach to develop “Tcm compounds [13].
99Tcm based receptor radiopharmaceuticals are not yet a clinical reality. The only successful case is that of 99Tcm - neogalactosyl glycoalbumin (NGA) for a bound receptor named hepatocyte binding protein (HBP) receptor, that binds galactose end glyco proteins. Tc-NGA would be useful for staging certain liver diseases (since HBP is implicated in liver malignancy) and for monitoring response to therapy [13]. The concept of BCA to attach receptor specific molecules with 99Tcm has been extensively investigated, but with limited success. Arduous chemical studies followed by receptor binding experiments have revealed poor specificity in most cases, like [Tc(V)O(DADS)-Progestin],[Tc(ra)(CO)(diethyldithiocarbamato-Spiperone)3], [Tc^-BATO-QNB] & [Tc(V)O(DADS)-QNB]. It appears that in all cases the complexation with technetium severely alters the bioactivity and precludes receptor binding. Attempts to overcome steric effects by increasing the distance between the essential functional groups have not been much successful. The important aspects to be reckoned with are molecular weight & size, lipophilicity changes, stereochemical effects and non-specific binding; two approaches called tridentate-monodentate (3 + 1) scheme (the former for facile chelation with Tc and the latter for presenting the receptor avid moiety) and pendant scheme have been pursued [13]. The novel concept of molecular mimics, i.e. Tc-chelate simulating a regular ring structure in a native receptor binding molecule, especially in a steroid (e.g. progesterone)/drug (e.g. morphine), is being pursued to target receptor sites for imaging using 99Tcm. Radiolabeled peptides have been recognized as the most likely successful candidates for imaging receptors (covered in another article in this Volume), based on the promising experience with mini labeled octreotide. The earlier stated problems in disguising and presenting technetium to the receptors persist, but scope for optimism is seen in this approach. In view of the importance of receptor imaging capability in health and disease, research efforts are continuing in more than one way [13, 14].
Calculation of radiopharmaceutical doses is a very crucial process and considered one of the main task of radiopharmacist as illustrated later. It is noteworthy to mention that there is the method of prescription calculation is completely different from conventional organic drugs. The most common method of calculation or computational chemistry of metal-based radiopharmaceuticals [14]. Other factors must be considered and may have role in pharmacokinetic and biodistribution, e.g. molecule geometry, dipole moments, ionic charge [15].
Eventhough methods of diagnosis and therapy are very important for both patients and physicians but bioevaluation or biological assessment protocol(s) are highly recommended [16, 17, 18, 19, 20]. The studies proved that some chelating agents (e.g. EDTA and DPTA) may chelate radionuclides to provide good images especially in cases of advanced cancer. For early diagnosis, Re-186(V) and Re-188(V)-DMSA are among drugs which will help in both diagnosis and monitoring cancer with good bio-distribution and pharmacokinetics properties [21]. This will enable specialist to understand if the radiopharmaceutical reached the appropriate location or site(s) (tumor for example). This also may enhance the delivery and improver the efficacy of drug [21]. Interestingly, measuring all three tumor space could be examined in vivo using drugs labeled with 95 mPt [22]. This protocol is valuable for cytotoxic drugs
Coupled with the ease of antibody production, these facts make 125 I-labeled immunoassays an ideal choice for many research activities [28, 29], especially in the medical field where radioisotopes are In short, even a cursory examination of the public health statistics of different countries on all continents shows the need for a simple, economic, and reliable analytical with this in mind, it is expected that [30].
The future development of radiolabeled immunoassays use reagents containing radioisotopes as indicators to monitor the distribution of free and bound antigens or free antibodies The distribution of free antibodies (free Immune radiological reagent analysis. (IRMA) [28, 29, 31, 32, 33].
Immunoradioassay (IRA) based on using beads of polystyrene as solid phase conjugated to avidin [34]. The commercially MoAbs is bio-tinylated with N-hydroxysuccinimide ester of biotin aminocaproate, and the detection Ab is I125.
A simple assay composed mainly of two steps;, mixing 2 labeled Abs with either sample or positive control [35]. This method has been used for hormonal analysis; Lutinizing hormones (LH), Follicle Stimulating Hormones (FSH), and prolactin [36]. For example, theaccuracy in analysis of prolactin is 8 (μU/ml (0.3 ng/ml), FSH is 1 mlU/ml, and LH is 0.9 mlU/ml [37].
There are 5 classes of magnetic particles(MP) (with/or without –CHO, NH2-, and COOh groups) were used to conjugate the 1st or 2nd antibody(Ab) using three methods; immmunoaffinity, adsorption, and chemical coupling to form 4 different MPAbs [38]. The 2nd immobilized Ab on polyacrolein MPs through -CHO and also the 1st Abs immobilized on -COO polystyrene MPs through -COOH to use in RIAs and/or IRMAs [39]. Commercial MPS were immobilized on NH2- for “Streptavidin” to separating polymerase chain reaction product quantitatively for CMV (Cytomegalovirus) [40, 41].
There are over forty eight cyclotrons and forty two reactors to provide radioisotopesfor biomedical applications [42, 43].
Nuclear reactors have played a main role in production of radioisotopes required for medical, industrial, agricultural purposes, education within the nuclear sciences and research. Millions of people worldwide have benefited from the 99Mo - > 99mTc generator for diagnostic imaging, and 131I for the treatment of cancer. Advances in accelerator and medical imaging technology are driving the demand for radioisotopes and radiopharmaceuticals required by nuclear medicine [44]. Conditions like public perception arising from concern for the environment either from radiation accidents or future storage of nuclear waste, additionally because the operating and replacement costs for aging reactors are factors influencing the prospects of future availability of radioisotopes. This may well be often reflected in recent decisions taken to initiate the de-commissioning of some research TRIGA reactor(s) that were installed in hospitals during the 1960’s [45].
Gene transfer therapy among cancer patients require monitoring emission for better management during treatment as presented in Figure 2 [46, 47, 48, 49]. The first clinical experience employing gene therapy was gained in 1989. leukocytes were transduced with heterologous DNA to look at the biological in vivo properties of tumor-infiltrating lymphocytes, and thereby optimizing antitumour imrnunotherapy strategies [50]. There are numerous approaches were undertaken to use powerful strategy of therapeutic gene transfer to the majority varieties of human diseases [51].
Selective prodrug gene therapy.
For effective imaging in diagnosis and tumor therapy [52], three enzymes -which are not commonly expressed by normal/non-infected cells- encoded by viral gene are required [53]:
Nucleoside kinase: This enzyme can convert selectively the unnatural nucleosides to nucleotides in gene-transfected cells or in virus-infected cells does not act on normal cells as in case of thymidine kinase(TK), e.g.
Tyrosinase: These enzyme can convert tyrosine amino acid to L-dopa, dopamine, dopaquinone and melanin via either neurotransmitter or pigmentation pathways, e.g. melanomas
Reductases: These enzyme are active mainly within the liver in hypoxic tissues. The process of bioreduction of active compounds may enhance the sensitivity of the hypoxic cells to the radiolabeled compound [55].
Nuclear Pharmacy or Radiopharmacy is currently a very well recognized pharmaceutical specialty and a sort of cooperation is highly recommended to build a strong and clear relation between Physcian in nuclear medicine and radiopharmacist. The concept of this relation is presented in Figure 3. In 1970, radiopharmacy speciality was recognized by the American Board of Pharmaceutical specialties. Nowdays, radiopharmacy has implemented in many health care systems with official credential certificate. Meanwhile, each country has its own regulatory radiopharmacy products [56].
Relation between Physcian in nuclear medicine and Radiopharmacist.
As the search continues for new products and newer areas of applications, 12jI compounds would provide the vital bridge between truly biological PET tracers based on nC/18F labeled compounds and the much more easily accessible SPECT tracers based on “Tcm and inIn products, thereby rendering a transition from PET to SPECT, that is from medical research to clinical utility, a reality. products would provide a fine complement to “Tcm compounds, especially for imaging process(es) involving slower kinetics of tracer and in the cases where conjugation of In-BCA with the bio-active substrate causes less alterations of the biological activity. Though the question “After 99Tcm, what next?” is posed time and again, the well-known attractive advantages of 99Tcm are not likely to be matched by any other tracer in the foreseeable future and consequently the impetus to develop 99Tcra based radiopharmaceuticals will continue. It could be safely predicted that the future of radiopharmaceuticals and in turn, clinical nuclear medicine, will continue to be dominated by “Tcm products, as has been the case in the past.
The authors declare no conflict of interest.
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. 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HEVC can achieve an average bit rate decrease of 50% in comparison with H.264/AVC while still maintaining video quality. To upgrade the HEVC used in heterogeneous access networks, the JVT-VC has been approved scalable extension of HEVC (SHVC) in July 2014. The SHVC can achieve the highest coding efficiency but requires a very high computational complexity such that its real-time application is limited. To reduce the encoding complexity of SHVC, in this chapter, we employ the temporal-spatial and inter-layer correlations between base layer (BL) and enhancement layer (EL) to predict the best quadtree of coding tree unit (CTU) for quality SHVC. Due to exist a high correlation between layers, we utilize the coded information from the CTU quadtree in BL, including inter-layer intra/residual prediction and inter-layer motion parameter prediction, to predict the CTU quadtree in EL. Therefore, we develop an efficient CTU decision method by combing temporal-spatial searching order algorithm (TSSOA) in BL and a fast inter-layer searching algorithm (FILSA) in EL to speed up the encoding process of SHVC. The simulation results show that the proposed efficient CTU decision method can achieve an average time improving ratio (TIR) about 52–78% and 47–69% for low delay (LD) and random access (RA) configurations, respectively. It is clear that the proposed method can efficiently reduce the computational complexity of SHVC encoder with negligible loss of coding efficiency with various types of video sequences.",book:{id:"5364",slug:"recent-advances-in-image-and-video-coding",title:"Recent Advances in Image and Video Coding",fullTitle:"Recent Advances in Image and Video Coding"},signatures:"Chou-Chen Wang, Yuan-Shing Chang and Ke-Nung Huang",authors:[{id:"26337",title:"Dr.",name:"Chou-Chen",middleName:null,surname:"Wang",slug:"chou-chen-wang",fullName:"Chou-Chen Wang"},{id:"194121",title:"Mr.",name:"Yuan-Sing",middleName:null,surname:"Chang",slug:"yuan-sing-chang",fullName:"Yuan-Sing Chang"},{id:"194122",title:"Dr.",name:"Ke-Nung",middleName:null,surname:"Huang",slug:"ke-nung-huang",fullName:"Ke-Nung Huang"}]},{id:"67911",title:"New Graphical Password Scheme Containing Questions-Background-Pattern and Implementation",slug:"new-graphical-password-scheme-containing-questions-background-pattern-and-implementation",totalDownloads:1096,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Security of authentication is needed to be provided superlatively to secure users’ personal and exchange information, since online information exchange systems have been developed according to internet speed. Therefore, aim of the chapter is to develop current graphical password scheme based on recall, create and implement a new graphical password scheme composed of three layer verification. We programmed our scheme in order to use in section of anonymous information exchange system and user’s registration of trading chat room. While we conducted survey on user by accessing participant to our system lied in participants’ local network and we analyzed in accordance with the average length of their created password and statistical significant of entropy bit. From the survey of total participants, our scheme has statistical significance, furthermore it was proved that it can secure form a variety of attacks as entropy bit was high.",book:{id:"7435",slug:"computer-graphics-and-imaging",title:"Computer Graphics and Imaging",fullTitle:"Computer Graphics and Imaging"},signatures:"Bulganmaa Togookhuu, Wuyungerile Li, Yifan Sun and Junxing Zhang",authors:[{id:"270420",title:"Mrs.",name:"Bulganmaa",middleName:"Bulgaa",surname:"Togookhuu",slug:"bulganmaa-togookhuu",fullName:"Bulganmaa Togookhuu"},{id:"409122",title:"Dr.",name:"Wuyungerile",middleName:null,surname:"Li",slug:"wuyungerile-li",fullName:"Wuyungerile Li"},{id:"409123",title:"Dr.",name:"Yifan",middleName:null,surname:"Sun",slug:"yifan-sun",fullName:"Yifan Sun"},{id:"409124",title:"Dr.",name:"Junxing",middleName:null,surname:"Zhang",slug:"junxing-zhang",fullName:"Junxing Zhang"}]},{id:"15138",title:"A Tutorial on H.264/SVC Scalable Video Coding and its Tradeoff between Quality, Coding 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Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,annualVolume:11410,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,annualVolume:11411,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,annualVolume:11413,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,annualVolume:11414,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. 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She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. 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He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:{name:"Association for Computing Machinery",country:{name:"United States of America"}}},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:"Manufacturing and Technology Integrated Campus – SENAI CIMATEC",institution:null},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:'"Politechnica" University Timişoara',institution:null},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"426586",title:"Dr.",name:"Oladunni A.",middleName:null,surname:"Daramola",slug:"oladunni-a.-daramola",fullName:"Oladunni A. Daramola",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Federal University of Technology",country:{name:"Nigeria"}}},{id:"357014",title:"Prof.",name:"Leon",middleName:null,surname:"Bobrowski",slug:"leon-bobrowski",fullName:"Leon Bobrowski",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Bialystok University of Technology",country:{name:"Poland"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"354126",title:"Dr.",name:"Setiawan",middleName:null,surname:"Hadi",slug:"setiawan-hadi",fullName:"Setiawan Hadi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Padjadjaran University",country:{name:"Indonesia"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"332603",title:"Prof.",name:"Kumar S.",middleName:null,surname:"Ray",slug:"kumar-s.-ray",fullName:"Kumar S. Ray",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Statistical Institute",country:{name:"India"}}},{id:"415409",title:"Prof.",name:"Maghsoud",middleName:null,surname:"Amiri",slug:"maghsoud-amiri",fullName:"Maghsoud Amiri",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Allameh Tabataba'i University",country:{name:"Iran"}}},{id:"357085",title:"Mr.",name:"P. Mohan",middleName:null,surname:"Anand",slug:"p.-mohan-anand",fullName:"P. Mohan Anand",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356696",title:"Ph.D. Student",name:"P.V.",middleName:null,surname:"Sai Charan",slug:"p.v.-sai-charan",fullName:"P.V. Sai Charan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"357086",title:"Prof.",name:"Sandeep K.",middleName:null,surname:"Shukla",slug:"sandeep-k.-shukla",fullName:"Sandeep K. 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