Selected features of Mavic 2 Enterprise drone.
\r\n\tThe fifth topic is “complications and drug side effects in the treatment of pigmentation disorders”. These include drug allergies, hyper- and hypopigmentation, persistent skin depigmentation, scars, skin burns, and the potential for skin cancer and skin lymphoma. The last topic is called “coping and support along with skin pigmentation diseases”. Increase the quality of life, psychotherapy, team therapy, and asking for understanding and support from family members.
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A SLD is a developmental disorder that begins by school age, although it may not be recognized until later [1]. It involves ongoing problems learning key academic skills, including reading, writing, and math. SLDs may also affect the way an individual is able to write, spell words, reason, recall, or organize information. SLDs are a lifelong condition that comes with varying levels of challenges unique to each individual. The impact that a SLD has on an individual can be minimized based upon the early detection and treatment of the condition. The treatments provided should be evidence based and selected as a result of the individual’s learning needs, preferences, and background [2]. Evidence-based interventions are methods that have been scientifically confirmed with regard to the selected treatment and proven effectiveness. In the current chapter, distinct types of SLDs will be emphasized. An overview of response to intervention (RTI), as well as an explanation of the multitiered system, will be illustrated throughout the chapter and within Figure 1. Progress monitoring is a key component to successful RTI implementation. This chapter will describe the assessments used to observe improvements. The benefits associated with RTI methods are discussed from multiple perspectives within this chapter. The role of speech-language pathologists (SLPs) and special educators is highlighted below.
\nThe figure presents each of the three levels (Tier 1, Tier 2, and Tier 3) of response to intervention (RTI). Each tier refers to the general descriptors of the strategies implemented in an increasingly intensive method [
This section provides a historical presentation of learning disabilities in the United States of America. Over the past few decades, students with learning disabilities have improved their ability to contribute to society as a result of receiving better services and a clearer diagnosis in relation to their deficits [3].
\nIn the past, learning and attention issues were not on the public radar. In 1905, the first publication by W.E. Bruner reported about childhood reading difficulties. It was not until the 1930s that the term dyslexia was coined. In the 1960s, in the United States of America, professionals first started to recognize the term learning disability (LD), which is later regarded as attention deficit hyperactivity disorder (ADHD). At this time, inclusion of students with learning disabilities and their nondisabled peers was not practiced in the United States of America [4]. Instead, students with learning disabilities were educated separately. In 1963, Samuel A. Kirk was the first psychologist to use the term learning disability at a professional conference. It was around this time that public school and the federal government started paying attention to learning disabilities.
\nThe Association for Children with Learning Disabilities (ACLD) was created in 1963. This organization is now known as the Learning Disabilities Association of America (LDA) and is spread across the United States of America. LDA’s vision is that all individuals with learning disabilities are empowered to thrive and participate fully in the society; the incidence of learning disabilities is reduced; and learning disabilities are universally understood and effectively addressed. LDA’s mission is to create opportunities for success for all individuals affected by learning disabilities and to reduce the incidence of learning disabilities in future generations. LDA provides a plethora of resources to educators, individuals, families, states, and professional resources.
\nIn 1969, the first federal law was passed to mandate services for students with learning disabilities. In 1973, an act that prohibits discrimination against people with disabilities in programs receiving public finding was passed. This act is referred to as Section 504 of the Rehabilitation Act. The US Congress passed the Education for All Handicapped Children Act (EAHCA), which popularized Free Appropriate Public Education (FAPE) for all students living in the United States of America, in 1975. The National Center for Learning Disabilities was founded in 1977, which was the former Foundation for Children with Learning Disabilities. In the 1980s and 1990s, trends continued to progress for individuals with learning disabilities. In 1985, the first dyslexia state law was enacted in Texas requiring instructional interventions to be put in place for students. In 1996, the National Institute of Mental Health completed research that identified the regions of the brain affected when a person has a diagnosis of dyslexia. The first learning disability web source, for parents and teachers, was established this decade. In the year 2000 and beyond, the awareness and research of learning disabilities continued to grow. Public laws and policies provided individuals with more rights and guidelines were established for professionals responsible for educating students with disabilities.
\nBrain research became fundamental in understanding learning disabilities and their causes. In 2001, legislation known as No Child Left Behind Act (NCLB) enhanced the states and district’s accountability for students’ progress. In 2002, research completed at Yale University looked at the differences between non-dyslexic and dyslexic brains. The researchers were able to view how the brains of those with dyslexia worked differently than non-dyslexic peers using MRI technology. Later in 2005, Yale University identified a gene associated with dyslexia. The overall public view at this time was evolving with regard to the way people perceived individuals who have a learning disability.
\nThe reauthorization of Individuals with Disabilities Education Act (IDEA) in 2004 increased responsibility of school districts and enhanced parental rights. Another important piece to the legislation is the alignment of IDEA and NCLB. As a result, response to intervention (RTI) was introduced to assist struggling students before they are referred for special education services. In 2007, researchers at the University College London used brain imaging to identify the areas of the brain that works differently when individuals have learning disabilities such as dyscalculia.
\nIn 2013, the
To summarize the new practices, instead of using a severe discrepancy approach to determine a learning disability, school systems must provide the student with a research-based intervention. The student’s performance must then be closely monitored related to their response to the selected interventions.
\nThe most common types of SLDs affect the areas of math, reading, and writing [1]. Learning disabilities can be best described as having difficulties in academic achievement and related areas of learning and behavior. There is more than one cause for SLDs. Often, learning disabilities are a result of an individual’s genetic makeup. The other cause may be from a stroke or traumatic brain injury that occurs later in an individual’s lifetime.
\nThis section of the chapter outlines several types of LDs. Some of the SLDs listed below are of high incidence, and others are of low incidence. It is also important to note that students who have a diagnosis of a SLD may have a comorbid diagnosis of another disability such as dyspraxia and attention deficit hyperactivity disorder (ADHD) or have patterns of weakness in executive functioning, which will impact the treatment they receive [2].
\nResponse to intervention’s (RTI) foundation is rooted in prevention of science and evidence-based practice. This approach embraces special and general education through the use of three target areas: (a) effective curriculum that provides opportunity for the majority of students to progress at the expected rate, (b) universal screening for early identification at-risk students so that these students may be provided additional, focused, intensive instruction while their progress is monitored, and (c) intensive interventions to aid students with learning difficulty [3].
\nRTI emerged in the field of education based on research on specific learning disabilities (SLDs) and reading interventions. The results of SLD research influenced education laws and classroom practice [4]. In the United States of America, special education is governed by IDEA 2004. IDEA 2004 encouraged schools to use research-based interventions to differentiate between students struggling due to poor instruction or to a disability [5]. Prior to the reauthorization of IDEA 2004, a student may qualify for services under the SLD category by showing a discrepancy between achievement and aptitude on a qualified assessment. As a discrepancy model, SLD is the term used to describe a student performing at average or higher intelligence on a standardized test and performing at a significant discrepancy (usually two standard deviations) in one or more academic areas. Shortcomings of the discrepancy model led leaders in the field of SLD to propose RTI as a valid method of identifying a student with a learning disability [4]. Through the use of powerful, scientific-based procedures for decision making, RTI focuses on improving the outcomes in both general and special education [5].
\nRTI is more than a method of identifying students with learning disabilities; it is a way to ensure better academic outcomes for all students. RTI shifts the focus from individual intrinsic abilities and characteristics to environmental variables and instruction [6]. The shift also requires a closer look at individualizing instruction within the classroom and consistent monitoring of progress through validated, research-based techniques [5]. Further, RTI encourages educators to be proactive in identifying learning delays, ideally to prevent those delays from becoming learning disabilities. Educators can intervene as early as preschool and kindergarten. This model differs from the past practice of allowing the opportunity for students to fail in middle-elementary grades (e.g., second and third grades) before intervening with special education services [3].
\nRTI’s proposed models involve two critical components: (a) evidence-based instruction and interventions implemented and (b) ongoing monitoring of student progress and responses throughout intervention. Valid instruction and interventions are defined as those leading to positive, reliable results for students with similar characteristics [5]. Thus, using RTI to identify students with SLD requires showing not only that a student demonstrates educational need but also an inconsistent response to high-quality general education instruction [7].
\nAs mentioned in the overview, RTI is a multitiered system. Although variations of multitier instructional systems exist, this chapter discusses the use of three-tier models. Various school systems nationwide have discussed and adopted the use of the three-tier model. Barnes and Harlacher [6] describe a typical implementation of the three-tier RTI system, which includes 60 minutes of core instruction for all students (Tier 1), 30 minutes of supplemental instruction for those students requiring additional interventions (Tier 2), and additional specialized instruction for those requiring maximum additional support (Tier 3). Therefore, as a student changes tiers (Tier 1 to 2 or Tier 2 to 3), the interventions’ intensity increases. This intensity is measured using several factors, including physical features of the intervention (duration, session frequency, and length) and the student-to-teacher ratio. As the student-to-teacher ratio decreases in size, interventions become more intense [8].
\nThough most illustrations and descriptions of multitiered systems depict a triangle or pyramid as three or more distinct levels, other models have been presented. One such visualization depicts the RTI model in a series of interconnected circles in order to emphasize the relationship and overlap of each targeted intervention. In either depiction, a pyramid or a circle, an effective three-tier model must provide instructional programming in a dynamic and fluent manner across all three levels [9].
\nAlthough the number of tiers and what interventions are provided at each tier may differ between different models, they all implement the general concepts of RTI by providing levels of increasingly intensive instruction and interventions with the same end goal: promoting positive academic outcomes. According to these models, approximately 80–90% of the students will be successful with just high-quality general education instruction, while 15–20% will need some form of targeted supplemental instruction. Only 1–5% will require intensive interventions [9].
\nIn Tier 1, general education teachers rely on the core curriculum and provide students with evidence-based, high-quality instruction. Students are regularly assessed using a variety of methods, including Curriculum-Based Measurements (CBM) to ensure that the students are responding to the instruction. Students who may need additional support are identified in Tier 1 and provided with alternate methods of instruction or interventions within the classroom setting [4]. As shown in Figure 1, Tier 1 instruction meets the needs of about 80% of the students within the general education setting; however, approximately 20% of the students do not reach grade-level standards within the core program under Tier 1. Therefore, additional instruction and intervention should be implemented [5]. The expected outcome for Tier 1 is for students to receive quality instruction and achieve expected academic and behavioral goals within the general education setting [9]. If the expected outcome is not attained, Tier 2 instruction and interventions are implemented.
\nWhen a student does not respond to additional instruction and intervention within the general education classroom in Tier 1, Tier 2 interventions are implemented. Thus, the intensity of interventions is increased (Figure 1). Tier 2 interventions can be provided within the school day, such as support from a reading specialist or through a specific research-validated intervention. Tier 2 interventions could also occur after school, such as tutoring [10]. In addition, the supplemental instruction is targeted to the specific areas of need and directly compliments the core instruction [9]. These interventions may require small-group instruction (four to five students) or one-to-one tutoring and more regular (biweekly) progress monitoring. Often taking 20 minutes per day to implement, Tier 2 interventions are implemented for up to 20 weeks. Students can exit Tier 2 services, if they meet grade-level benchmarks. Some students may continue for the full 20 weeks in order to make sufficient progress [5]. The documentation of a student’s responses is critical within Tier 2 interventions. The data collected can be used to determine whether a more formal special education assessment is necessary [6].
\nThe expected outcome of Tier 2 is for students to receive more targeted instruction after not meeting general class expectations and exhibiting the need for supplemental support. Targeted Tier 2 instruction can take place within the general education classroom or in other settings in the school, such as pullout situations. Students’ instruction and interventions should be modified and differentiated while providing more specialized equipment and technology, as needed, to target each individual student’s instructional needs. Students who make insufficient progress in Tier 2 then are considered for Tier 3, intensive intervention. There should be evidence-based documentation and evaluation to support evidence of insufficient progress [9].
\nIf a student does not make acceptable progress within provided supplemental instruction and intervention within Tier 2, they can then be referred to Tier 3. Tier 3 includes more intense, specifically designed instruction and/or special education services [4]. Tier 3 is a high-quality, intensive intervention that includes interventions that are individualized to meet significant needs, including various disabilities. About 2–5% of the students who did not respond as expected to Tier 1 and Tier 2 interventions are provided more intensive interventions within Tier 3. The length of time required to implement Tier 3 interventions will often replace some portion of the core curriculum, at least temporarily. Depending on the district or school policy and decision-making process, Tier 3 interventions may or may not include special education services (Figure 1). Through continued progress monitoring of the documentation of interventions and further evaluation, often students within Tier 3 will be referred to special education and may qualify for special education services [5]. However, to assume that Tier 3 is only for special education is a myth. In RTI, it is expected that students with learning disabilities of all kinds are represented in all tiers of intervention, including students who are not classified as special education students. This expectation depends on universal screening of the particular skill domain, behavior, and outcome of interest [3]. The expected outcome for Tier 3 is to provide students who have more significant needs with intensive, evidence-based interventions within a range of educational settings [9].
\nA key component to successful RTI implementation is a formal and organized assessment system. This component is crucial in the decision-making process when determining what tier to place students. Assessment, progress monitoring, and instruction are intricately tied together within the RTI model. Students are usually placed into their initial tier through the results of benchmark assessments, though teacher observations can be considered as well. Once students are placed in their appropriate tiers, they are progress monitored to track how well they are responding to their current instruction. If the student is not progressing at the expected rate, a change in instruction, interventions, or possibly their tier needs to be considered [11]. Ongoing progress monitoring serves two purposes: (a) the data collected is used to make decisions about instruction, interventions, and placement within tiers by evaluating the students’ strengths and needs, and (b) continual progress monitoring determines whether the student is responding to the intervention. The data collected from continual progress monitoring aids in the decision-making process whether a student needs to continue receiving intensive intervention services with Tier 2 or Tier 3 or can be exited from the tier they are currently placed [5].
\nIt is important that students are assessed and monitored frequently and continually, in order for schools to identify and respond quickly when students are not meeting academic standards or the aligned goals for intervention [6]. With RTI, decisions regarding progress are more high stakes and less self-correcting. Failure to progress monitor and respond to students that are not meeting the targeted goals can potentially cause them to be referred for special education services, resulting in a special education label and placement. With that, a more intensive intervention is implemented and often comes with well-known special education side effects such as reduced time with nondisabled peers, stigmatization, and so forth [7].
\nFor all students in Tier 1, benchmark assessments should be taken three to four times per year. Often, schools throughout the United States of America follow a fall, winter, and spring benchmark time frame. RTI models differ on recommended frequency of progress monitoring within each tier. Most often, it is suggested for students in Tier 3 to be monitored weekly. Some models suggest two to four times per month, which on the high end of the suggested times equates to weekly monitoring. Suggestions for Tier 2 include twice a month and one to two times per month. When choosing a progress monitoring schedule, consider the possibility of a student in Tier 2 or Tier 3 being referred for special education services. It is encouraged to have a minimum of six to eight data points that show a student’s lack of response to interventions and/or instruction and need for more intensive interventions. Although schools throughout the United States of America may use different assessment systems, procedures, and progress monitoring time lines, the two purposes of RTI are met by using data from formative assessments (i.e., ongoing assessment used to monitor student progress while the instruction is occurring) in order to guide the decision-making process about instructional placements and decisions [6].
\nThe RTI framework as a whole is beneficial in that it evaluates the external factors that may be impacting a student’s progress before determining if the struggling student has an intrinsic learning deficit or disability. Further, the RTI framework evaluates instruction and interventions, discourages giving up or labeling a child after just one intervention, and encourages schools and educators to use creative strategies to meet individual student needs while moving toward more intense interventions, as needed [4]. Though there are many benefits of RTI, this chapter will focus on three primary benefits of the framework: (a) reduction of inappropriate special education referrals, (b) student benefits, and (c) benefits to schools and teachers.
\nThe number of students who are referred and who qualify for special education services is reduced when RTI is implemented effectively, as found in several studies [5]. If effective interventions are implemented within Tier 1 and Tier 2, inappropriate special education referrals and the need for extensive Tier 3 instruction are reduced [6]. Numerous studies have shown the utility of RTI programs. One study showed consistent decreases in special education placements. In particular, that study showed a 39% decrease in special education placements in kindergarten, a 32% decrease in special education placements in the first grade, a 21% decrease in special education placements in the second grade, and a 19% decrease in special education placements in the third grade. Another study reported that engagement in Tier 1 interventions reduced the percentage of students going to special education by 12%. Participation in all three tiers reduced the rate of students placed in special education by 8% [12]. Because RTI helps ensure that all students receive quality instruction and proper supports, it lessens the likelihood that a student will be misdiagnosed with a disability and placed in special education [4].
\nOne study on the barriers and benefits of RTI sought feedback from special education teachers about the benefits that students experience from RTI [13]. A majority of responses from the surveyed teachers showed that students were receiving better instruction that more quickly identified and addressed problems so that students did not fall further behind waiting for necessary assistance. Other responses indicated that teachers found the RTI process to help correctly identify students with learning disabilities during the special education referral process so that students without special needs are not improperly shuffled into special education programs. However, the study noted that many teachers found the benefits of RTI to extend beyond special education programming, for teachers noted that the one-to-one intervention strategies of RTI assisted students across the learning spectrum [13].
\nRTI has also been found to lead to other benefits for schools and teachers, including better data collection on student growth and achievement [13]. Furthermore, teachers have disclosed that the individualized nature of RTI has helped general education teachers and educational teams more precisely and accurately identify individual skill areas or behaviors in which a student is struggling. Finally, many educators have noted that RTI has increased collaboration between teachers and parents [13].
\nThe American Speech-Language-Hearing Association (ASHA) defines RTI as an increasingly intense, multitiered system to providing services and interventions to struggling students and encourages speech-language pathologists (SLPs) to assist in identification. As mentioned before, this approach incorporates increasingly intensive levels of intervention, meeting the student where they currently are, in terms of academic success. Universal speech screenings, frequent progress monitoring, high-quality and evidence-based interventions, and response data are the core foundations of RTI that are utilized, in an attempt to identify students early and provide them with the support to be successful.
\nSpeech-language pathologists play a vital role in identification of students with needs, both those with speech-language impairments and those students presenting with specific learning disabilities. Prior to the introduction of RTI, students were found eligible for special education services based on discrepancies between performances on standardized tests and performance in the classroom. In hearings related to the reauthorization of IDEA, the US Congress found that using these measures was insufficient to identify learning disabilities, as the IQ-achievement discrepancy formulas that had previously been utilized cannot be applied in a reliable and valid manner. In addition, students living in poverty or students from culturally and linguistically diverse backgrounds may be mistakenly viewed as having intrinsic intellectual limitations, although their differences on such tests are really reflective of a lack of experience or educational opportunity.
\nWith RTI in place, students are able to access these services based on their personal performance or response to increasingly intense interventions provided to them in their area of deficit. Speech-language pathologists can be integral to successful RTI initiatives in a school [14]. In Tier 1, they should be providing consultation services regarding possible disorders and impairments within their scope of practice and dissemination of information regarding speech-language disabilities and how they interplay with curriculum, assessment, and instruction.
\nAccording to ASHA, there are many ways in which speech-language pathologists can make unique contributions to RTI in their school. They can explain the role that language plays in curriculum, assessment, and instruction, as a basis for appropriate program design, as well as explain the interconnection between spoken and written language. They can identify and analyze existing literature on scientifically based literacy assessment and intervention approaches and make recommendations on their implementation in the school. Speech-language pathologists can also assist in the selection of screening measures and plan for and conduct professional development on the language basis of literacy and learning [15].
\nTrainings that include information regarding typical articulation/phonological errors and the ages when they should no longer occur could be appropriate trainings for a school-based speech-language pathologist to provide to his/her colleagues. By informing classroom teachers of these developmental norms, it is likely that more students will be properly identified through screenings and assessments and that interventions will be implemented for the students who need it most. Furthermore, evidence supports the use of dynamic assessment for reducing overidentification and identifying students for small-group language intervention [16].
\nSpeech-language pathologists should be presenting information on a variety of speech-language disorders including but not limited to language impairments, speech disorders, phonological impairments, dysfluency (stuttering), and voice production problems/vocal abuse. Another important component of Tier 1 is the instructional information that speech-language pathologists can provide to their colleagues including special education teachers, teachers, and other support staff in the school, who may be making referrals [17]. Providing other professionals with strategies to address general speech-language difficulties can increase the effectiveness of general teaching procedures and assist all students in the classroom.
\nMany techniques can be implemented quickly in the classroom and can support improved student performance. For example, students demonstrating difficulty learning-related vocabulary may benefit from direct and explicit strategies, such as teaching the vocabulary in context, using word webs, pre-teaching key words and concepts, and using visuals (gestures/pictures) to teach meaning. Other strategies that are effective across subjects and grade levels include stating the objectives; providing direct instructions; utilizing multiple modalities; engaging students in group activities; using feedback, reinforcement, and recognition; highlighting similarities and differences; and utilizing advanced visual organizers [18].
\nAs previously mentioned, RTI also provides schools with an opportunity to take preventative steps by providing evidence-based practices to groups of students that are at risk. Reading is a fundamental skill for academic success, and it is closely linked to phonemic awareness. Phonemic awareness is the ability to understand that words are composed of individual sounds (phonemes) and manipulate those sounds, sound sequences, and sound structures in a syllable or word. It may be difficult to develop for many groups of students, including those with phonological impairment, speech impairment, students learning English as a second language and those from low-income households [19]. Strong phonemic awareness has been found to be a predictor for reading skills, and in its absence, students will struggle with reading [20]. The curriculum for upper grades relies heavily on independent reading skills, and students who have struggled to build a solid foundation in the early grades will begin to demonstrate difficulties in all academic areas based on their reading difficulties. Speech-language pathologists can assist by providing classroom teachers with evidence-based strategies for teaching phonemic awareness. For example, students struggling with literacy skills have been found to benefit from structured teaching activities such as name writing, alphabet recognition, and phonological awareness activities. If incorporating these supports into the curriculum class-wide does not prove to be intense enough, and the student continues to perform below curriculum-based measures and/or benchmarks, he/she will be referred for Tier 2 of RTI to be provided with need-based learning in intensive small groups.
\nTier 2 intervention typically is provided in collaboration with the general education teachers. It usually consists of small groups of students being provided with high-quality, but specific and explicit, short-term instruction in the area of difficulty. This Tier is the most important in terms of using clinical expertise and data from performance during Tier 1 to identify students that need these groups. Dynamic assessment can take place over a relatively brief period, and his/her response to intervention can be an indicator of their ability to progress academically throughout the school year [21].
\nIntervention at this stage will vary greatly depending on the nature of the difficulty that the student is having. For example, if the student is struggling in the area of articulation (the actual production of sounds based on place, manner, and voicing) and is stopping his/her /s/ sounds (replacing the /s/ sound with a sound like /d/ or /t/), the speech-language pathologist may provide the classroom teacher and parents with specific strategies for practicing and producing the correct /s/ sound. Articulation strategies can include word lists with the target sound, modeling, and descriptive instruction for production and embedding “traditional” articulation therapy techniques, such as sound discrimination and correcting productions until the sound can be produced in all contexts and speaking situations [22]. If progress is not made and/or the misarticulated sounds further impact the student’s academic and/or social/emotional functioning in the classroom, a referral to Tier 3 may be warranted.
\nStudents experiencing dysfluencies (stuttering) may also require Tier 2 if their dysfluency is impacting their academic progress or their social/emotional functioning in the classroom, but it is unclear whether there is an obvious disorder. The speech-language pathologist should identify one to three possible strategies that the classroom teacher can implement such as modeling, providing think-time (for the student before providing a verbal response), refraining from interrupting [23], and decreasing stress in the classroom. If dysfluent behaviors become pervasive across environments, the student may need to be referred to Tier 3 and/or require therapy provided by a speech-language pathologist with expertise in treating stuttering [24].
\nSpeech-language pathologists may also receive referrals to Tier 2 for students experiencing voice difficulties, such as hoarse voice, problems with nasality, or decreased volume. Recommendations for the classroom may include reviewing good vocal hygiene such as the importance of hydration and appropriate volume/loudness but may also implement self-monitoring strategies for the student, such as charting appropriate vocal productions throughout the school day.
\nTier 3 provides the most support prior to a referral to special education. Where oftentimes the small groups in Tier 2 may meet two times a week for 30 minutes, the students identified as needing Tier 3 may receive up to double the amount of time previously allotted in Tier 2. Tier 3 instruction is characterized by more explicit, individualized, and systematic instruction to support students’ speech-language skills in addition to indirect activities that may include helping to select research-based interventions, completing student observations, assisting with frequent progress monitoring, and helping the team make decisions regarding referral for special education evaluation.
\nSpeech-language pathologists may need to complete a detailed and individualized language/literacy battery of formal, informal, and curriculum-based assessments, including assessment of receptive and expressive vocabulary and language, articulation, phonology, pragmatics, reading, and written language, as well as the speech components of voice, fluency, and resonance. Interpretation of these assessment results will further assist in determining if the student has special education needs, and if indicated, the basis for the Individualized Education Plan (IEP) goals [25].
\nMany school-based speech-language pathologists often have heavy caseloads, overflowing with mandated individual and group sessions and making the task of being involved in RTI a seemingly impossible one, but as an integral part of the multidisciplinary educational team, their therapeutic interventions are critical to student success. Prevention of speech, language, and communication disorders is one of the key roles and responsibilities of school-based speech-language pathologists and as such can complement and augment RTI services..
\nIn summary, RTI has changed the way educators and clinicians identify and support students who may be experiencing difficulty, in an educational setting. The intention of intervening early on with a treatment-oriented diagnosis process is to prevent students from falling too far behind their peers, requiring special education services. The reauthorization of IDEA (04) has changed the landscape for educators and SLPs, alike. RTI is a multitiered approach that allows students to receive support at a level that is optimal and individualized for their specific learning needs or deficits. In Tier 1, students receive instruction within the general education setting [9]. In Tier 2, interventions can be provided from a specialist during the school day or from a tutor [4]. In Tier 3, intensive instruction and/or special education services are individualized to meet significant needs of a student [4]. Figure 1 provides an illustration of RTI and an overview of each tier. The emphasis on evidence-based interventions, constant monitoring, and systematic support remains the primary focus of RTI methods.
\nDigitization has become an ongoing goal on the agenda of economic development and social transformation. It offers a broad perspective on the very near future of humanity embodied in current paradigms such as the web-driven economy, e-government, e-society, or e-communities that are based on digital democracy and promote it at the same time. Digitization is a priority all over the world and is seen as a strategy for the profound development of all sectors of human activity. One of the most relevant examples is the program promoted by the European Commission under the slogan “A Europe fit for the digital age”, which guides how digital technology is changing people’s lives by empowering people with a new generation of technologies [1]. Several concepts are now circulating such as big data and cloud computing and a number of technologies such as data mining, data analytics, data fusions, and deep learning are currently used and are constantly improving to keep up with the huge production of data in all fields.
Cultural heritage is a part of data production and has been contributing to the informational treasure of humanity for millennia. The digitization of cultural heritage is only a step in collecting and manipulating data with two major purposes: storage for information preservation, respectively data analysis for the study, and advanced research. A recent European Commission report on shaping Europe’s digital future focuses on 3D digitization of cultural heritage [2]. This is a roadmap for the digitization of tangible cultural heritage that highlights that the integration of data obtained through different scanning techniques is the right approach for the future. Knowledge of technologies for transforming tangible heritage objectives into data by scanning across different spectral bands and dimensional measurements, including software components for data analysis and presentation, is very important. The digitization of tangible cultural heritage is not only a fashionable technology but a tool that tends to become a standard for the collection, preservation, and dissemination efforts of arts and cultural heritage worldwide [3]. All in all, digitization is a necessity for a better knowledge and interpretation of things, so research becomes much more efficient using data instead of physical artifacts, especially in the case of tangible real estate. Sometimes access to the physical object is impossible, or very expensive, and then, a set of data captured with the right sensors is very useful. On the other hand, data become more democratic and thus can reach the general public through the media or virtual products in the service of knowledge of cultural heritage. In fact, through digitization, tangible cultural heritage becomes digital heritage, which is a subcategory of intangible cultural heritage.
In the last decade, drones have been used in many industries such as construction and infrastructure, agriculture, environmental monitoring, mining, GIS, and so on. For all these areas, drones provide imaging data of various types: single aerial pictures, thermal and multispectral images, stereoscopic images, video content, data from laser scanning, and remote sensing. A significant number of bibliographic sources report on drone technology and airborne sensors and their specific applications and services. Most case studies are presented even by professional drone manufacturers, and a wide collection of information can be found on their websites, for example, [4, 5, 6]. A recent report on the leading manufacturers of drone technology, including their applications, can be found in the reference [7].
At present, drones have begun to be part of the arsenal of means of investigating cultural heritage, offering the possibility to fly over and supervise heritage objectives from the air, with low operating costs. In principle, they offer photogrammetry services but the applications are open to possible remote exploration and sensing tasks in archeological sites, instead of humans. An extensive and recent synthesis of the use of drones in the service of cultural heritage, including examples of applications and case studies conducted around the world, can be found in [8].
A drone is an unmanned aerial vehicle (UAV) that can be remotely controlled by a human operator in a specific area of action. This type of aircraft is an excellent platform for various scanning equipment, and sensors capable of transmitting acquired data in real time, as well as its current position. Drones can provide a wide range of services, but most applications include airborne surveillance and monitoring tasks. There are drones for military purposes and drones for civilian use, but we will discuss here drones with civilian applications.
The basic mission of drones in the service of cultural heritage is to scan various objects, artifacts, sets of objects, places built of cultural interest, and using different techniques for obtaining digital images.
Traditionally, aerial photogrammetry is the science and technology of obtaining reliable information about physical objects and the terrestrial environment through the process of recording, measuring, and interpreting photographic images captured from height. Currently, digitization has extended the field of photogrammetry to the analysis and processing of images based on mathematical and geometric models with software-implemented algorithms. Automatic image processing works with huge amounts of data that drones are able to provide by mobile scanning over areas of interest.
Aerial images can be processed and interpreted in different ways. One of the most used methods is a 3D reconstruction based on 2D images. This task defines particular uses of the drone in controlled overflight scenarios, which differ from one objective to another. Another method is orthophotography through which the objectives are mapped 2D, resulting in the digital map of the objective and the area flown over with the planimetry information. These methods include geometric models and algorithms for analytical geometry. Another category of methods aims at chromatics and image illumination, which involve extracting components and color ranges, estimating specular reflection, determining ambient lighting and its interaction with materials in order to render physical objects. This is where digital image analysis algorithms take place in the visible or multispectral domain. The combination of methods, for example, orthophotography with chromatic methods produces orthomosaic maps, and by the combination with multispectral data, various indexed maps are obtained based on normalized difference vegetation index (NDVI), optimized soil-adjusted vegetation index (OSAVI), chlorophile map, or processing CIR Composite (color infrared), or digital surface model (DSM).
This is a technique for directly obtaining 3D images using laser radiation using LiDAR (laser imaging, detection, and ranging) devices. Unlike photogrammetry, which is a passive method of capturing images, LiDAR is an active method that involves laser emission in the NIR or UV spectrum. Mobile laser scanning is also beginning to be accessible to drones through aerial LiDAR equipment that has evolved to meet the requirements of weight, size, and performance. Laser scanning involves technical conditions and additional requirements to photogrammetry. Knowing the position of the drone as accurately as possible at all times is crucial for the quality of LiDAR data and therefore, these systems have integrated inertial navigation sensors with very high accuracy. Laser scanning has several definite advantages versus classical photogrammetry, but it cannot surpass resolution performance, image realism, data accuracy, and ultimately the cost of photogrammetry equipment. In the LiDAR technique for each scan radius (direction) only two parameters are obtained: flight time—which is directly proportional to the distance and intensity of the reflected radiation. With this information about each scanned point, a synthetic image of the objects is built respecting their geometry with a certain precision, while all the chromatic characteristics are conventionally chosen. However, some advantages prevail for laser scanning technology: It can operate at night, in an atmosphere with clouds and smoke, and can reconstruct more precisely the surfaces covered by vegetation. Also, the time required for post-processing LiDAR data is much shorter than when processing photo images. In various applications, LiDAR technology is used in addition to the classic photo-video technique.
The drone, as a system, is capable of providing raw imaging data for the above-mentioned processing, while a suite of application software programs effectively performs the appropriate processing to extract the desired information. In fact, these are stand-alone software tools that perform advanced data processing including artificial intelligence techniques.
The configuration of drones for civilian use is of a VTOL (vertical take-off and landing)-type aircraft with fixed wings or the most popular with rotary wings. Here are the main component systems (subsystems) of a professional drone for civilian use:
The structure and the propulsion engines: It constitutes a unitary assembly made of resistant and light materials in a compact and aerodynamic configuration with rotor-type propellers. The structure usually has foldable elements so that it can be stored and transported more easily.
The sensor system: It provides data for drone self-monitoring and navigation data. On the main directions of movement, there are video sensors for detecting obstacles and measuring the distance to them and also IR sensors for detecting and telemetry of obstacles up and down. For this purpose, the drones can also be equipped with additional (redundant) ultrasonic or LiDAR sensors. Navigation sensors include the compass, the global navigation system receiver (for GPS coordinates), and the inertial measurement system (IMU) consisting of a gyroscope and accelerometers.
The airborne surveillance system: It generally consists of a video camera with controllable orientation, but may also include a thermal imaging camera or multispectral cameras depending on the mission of the drone.
The communication system: It contains the airborne transceiver with separate frequency channels for the remote control of the drone flight and the airborne systems, respectively for image downlink, as well as the paired transceiver in the portable remote control unit. The communication subsystem also contains a number of interfaces for data communication such as the USB port, the micro-SD card slot, and the port for connecting additional accessories to the drone (beacon, speaker, lighting projector).
The power system: It includes the drone battery that supplies all the subsystems in the drone composition, respectively the battery of the remote control equipment.
The electronic command and control system: It represents the brain of the drone and it ensures all the functions of the onboard subsystems such as control of the propulsion system, control of sensors, control of telecommunications, and control of surveillance equipment. The control of the major subsystems of the drone includes various parallel command and real-time control tasks such as independent speed control of each engine, stabilization of surveillance cameras, battery control, and radio power control. The brain structure of the drone is based on a multiprocessor architecture with a powerful master processor and several slave processors with distinct responsibilities.
The remote control equipment: It is the user’s portable unit—an HMI (human-machine interface) that provides the graphical control interface and the effective means of command of the drone (buttons and sticks). Usually, this role can be provided with a tablet or smartphone, but professional drones come with their own dedicated remote control unit that includes the display.
Last but not the least, a special and vital component of drones is the software system that is distributed on both components: built-in drone, respectively on the portable remote control unit. The software component actually defines the drone’s brain and its so-called intelligence, effectively ensuring all the processes for its proper functioning.
Figure 1 shows an overview of the Mavic 2 Enterprise model, where the main subsystems can be identified. Full details can be found by accessing the official manufacturer’s website available from: https://www.dji.com/mavic-2-enterprise/downloads
Professional drone Mavic 2 Enterprise with native surveillance camera mounted in front of the gimbal joint.
Here, we will review the basic characteristics of drones and detail the functional parameters that are relevant to the tasks of digitizing the objectives of tangible cultural heritage.
We mainly distinguish between technical characteristics and operational characteristics, the latter depending largely on the former, and together, they determine the use class of the drone, its performance, and finally the purchase price on the market. First of all, we need to understand that drone performance is the result of a technical compromise that is reflected in their operational capabilities. Current technology manages to optimize this compromise by balancing power and speed requirements versus flight distance and height, weight and gauge versus air range (maximum flight time), data processing, and transmission capability versus sensor resolution.
In general, the mission of a drone is to acquire images with very good resolution from precisely defined and very well-controlled positions. In other words, drones must provide quality digital material for photogrammetry and image processing techniques. Thus, in addition to the general performance of maximum speed, maximum service ceiling above sea level, and maximum flight time, the following features are very important: hovering accuracy range, parameters of the camera, and gimbal of camera. In Table 1 has given selectively these characteristics for a reference model—the Mavic 2 Enterprise drone.
Technical/operational feature | Value/limits | Notes |
---|---|---|
Max takeoff weight | 1100 g | |
Max speed | 72 kph | Near sea level, no wind |
Max ascent speed | 5 m/s | |
Max descent speed | 3 m/s | |
Max service ceiling | 6000 m | Above sea level |
Max flight time (no wind) | 31 min | At a consistent speed of 25 kph |
Max hovering time (no wind) | 29 min | |
Hovering accuracy range | Vertical: | |
| With vision positioning With GPS positioning | |
Horizontal: | ||
| With vision positioning With GPS positioning | |
Parameters of camera | Effective pixels: 12 megapixels | Sensor: 1/2.3″ CMOS |
Auto focus at: 0.5 - ∞ | ||
Max image size:
| Photo format JPEG, DNG (RAW) | |
Video resolution:
| Video Format MP4/MOV (MPEG-4 AVC/H.264) | |
Gimbal | Mechanical range: Tilt: −135 to +45° Pan: −100 to +100° Controllable range: Tilt: −90 to +30° Pan: −75 to +75° Stabilization: 3-axis (tilt, roll, pan) Max control speed (tilt): 120°/s Angular vibration range: ±0.005° |
Selected features of Mavic 2 Enterprise drone.
Considerations related to the accuracy of data collected by drones are discussed in [9]. The quality of the images provided by a drone is described by three essential characteristics [10].
The pixel resolution of an image is the number of pixels that make up the image. It is expressed by the number of columns and rows, such as 4056 × 3040, or directly by the total number of pixels, such as 12.3 Mpixels (4056 × 3040 = 12,330,240). This parameter is important for data sharing and storage, image display, and digital zoom.
Ground sampling distance (GSD), in mm/pixel, is the distance between the centers of two adjacent pixels, measured on the object observed in the image. This parameter depends on the size of the camera sensor and its actual number of pixels, but also on the distance to the photographed object. For example, a GSD of 1 mm/pixel means that one pixel per image is 1 mm in the real world. A smaller GSD means that the object will appear larger and that smaller details will be visible in the image. For example, a photo image can reach one million pixels/m2, while a LiDAR image can only reach a few hundred pixels/m2. Ground sampling distance is an important measure to consider for photogrammetry and measurements in images. However, GDS does not fully describe the ability to detect and characterize an object or detail in an image.
Spatial resolution or angular resolution describes the smallest details visible in the image. Unlike theoretical GSD, spatial resolution can be expressed in a different unit, which takes into account blur, image noise, contrast, and in general the effects of image processing: compression, denoising, edge clarity, etc. Spatial resolution is therefore a correct metric to quantify the ability to detect and characterize an object in the image. Spatial resolution is often expressed in “pairs of lines per millimeter.” This unit is used to describe the spatial frequency of alternating black and white line patterns.
Finally, another photometric parameter that influences image quality is the ISO exposure value at the image sensor. Under normal lighting conditions (daylight), the exposure value is set to the lower limit of the range values and vice versa, and at lower lighting levels, the exposure value is set above. However, a high ISO value of exposure produces image noise, and a long exposure time produces motion blur when the camera moves. This reduces the image quality, and eventually the ability to distinguish small details in the image.
A survey of the latest applications of the use of mandrels for cultural heritage purposes reveals two aspects. First, there are various subdomains or particular purposes with concrete tasks where drones, as providers of digital content, prove their usefulness. Specific applications can be classified as follows:
Reproduction of virtual models, especially for architectural heritage, is the widest class of applications. HBIM (historical building information modeling) technology as part of BIM (building information modeling) technology is one of the most used digitization activities in the service of the tangible cultural heritage in which drones prove their effectiveness. Here, based on panoramic images captured by drones, 3D reconstruction is the most frequently addressed technique. A suite of cultural heritage virtualization projects can be viewed on the following websites: [https://www.3deling.com/heritage/], [https://iconem.com/en/].
Non-destructive analysis of heritage sites and objects is an area of activity that can fully exploit the drone service in data acquisition. We mention here exterior and interior photogrammetry missions on frescoes, mosaics, upholstered surfaces, decorative stucco, and bas-reliefs.
The conservation of the material patrimony requires as accurate and complete information as possible in the effective restoration activity. The reference digital models help both the restoration work and the sustainable preservation and management of the heritage.
The actual restoration action can be automated and effectively driven by data by robotic interventions and reconstruction by additive techniques, such as 3D printing technology.
Artifact authentication is another activity that can fully benefit from the digital support provided by drones in special situations when the place cannot be explored on land or the object is in dangerous or contaminated places and when there is a risk of destroying the artifact by other types of examination.
Second, the review of recent literature reporting various applications of drones in the service of cultural heritage reveals the complementarity of several digitization technologies with that of drones, as well as strengths, weaknesses, and limitations of these technologies [11, 12, 13, 14]. As the main technique for capturing images, traditional aerial photogrammetry has now become accessible through drones at a very good performance-cost ratio. Photogrammetry and laser scanning are the basic techniques applicable by various methods with distinct equipment, but for the production of digital content of cultural heritage objectives, several scanning techniques are available. The main concepts frequently used in the digitization of the material cultural heritage are based on the following methods:
Close-range photogrammetry (CRP) is considered when the subject is observed from less than 400 m either from the ground or from the air. This is a cheap and sufficiently accurate method for 3D photogrammetry based on stereoscopically associated overlapping 2D images. For aerial applications with drones, CRP is the ideal solution because the cameras have a lower weight and size, compared to laser scanners, for example.
Structure from Motion (SfM) is a technique based on automated photogrammetry that facilitates the collection of moving images. This is the standard method for 3D reconstruction in the field of cultural heritage. In principle, it is applied within the CRP with the determination of the best overflight height and the establishment of the optimal spatial resolution, and the orthophotography acquisitions with an overlap of at least 60% are scheduled. The image collection is then processed with SfM software based on 3D reconstruction algorithms.
Airborne LiDAR scanning (ALS) is a complementary or alternative photogrammetry technique to create a digital terrain model (DTM) or digital elevation model (DEM). 3D reconstruction of cultural heritage objectives by laser scanning with drones is becoming an increasingly accessible technology.
Terrestrial laser scanning (TLS) is used as a basic technique or to complete the acquisition of 3D images of cultural heritage objectives with fixed ground equipment, which gives a very good data accuracy.
Mobile laser scanning (MLS) contributes to massive point-capture technology along with photogrammetry, using LiDAR equipment mounted on land vehicles, ALS, or with handheld scanning devices. The use of this equipment involves special SLAM (simultaneous localization and mapping) technology for capturing images and point clouds in motion and real time.
In specific applications for the material cultural heritage, there are some peculiarities that influence the scanning techniques used, as follows:
Objects are motionless, so there are virtually no relative dynamics and images can be considered static.
Some artifacts require photography from a short distance outdoor but also indoor.
Indoor, natural lighting is usually poor.
In inaccessible places, the real size of objects is generally not precisely known, so the exclusive photogrammetric interpretation is relative.
Interesting studies addressing the combined use of air and ground scanning technologies for cultural heritage objectives are reported in [13, 15].
We have seen that drones can be used successfully for both outdoor and indoor photogrammetry and laser scanning operations. Most applications are outdoor missions for HBIM tasks but some indoor missions are suitable for drones, in concrete situations these being the only means that can make data acquisition at reasonable cost-effectiveness. In [16], it is presented a comparative study of digitization of land surfaces, photogrammetry versus laser scanning, conducted for four types of drones. These results are interesting and useful for professionals in the field of cultural heritage. A project reported in [17] focused on HBIM for Byzantine churches in Cyprus using exclusively low-altitude outdoor photogrammetry, provides methodological details, and results obtained with a drone equipped with a 20 MP camera. In Romania, there are some important cultural heritage objectives that are being investigated by photogrammetry with the help of a drone. One of them is the large architectural monument—the medieval castle named Corvin Castle, also known as Hunyadi Castle, in Hunedoara (Figure 2). The other is the Adamclisi Fortress in Dobrogea, which is an ancient Roman architectural complex, today in ruins (Figure 3).
The Corvin castle in Hunedoara, Romania.
The Adamclisi Fortess ruins in Dobrogea, Romania.
These applications require the planning of particular flight missions with predefined itineraries for photogrammetric capture with different viewing angles on ground objectives. Usually, two gimbal angles are used for the camera: −90°, that is, vertical downward direction, called nadiral view, and oblique direction at −45°. Practically, a methodology and planning of photography are established for each objective. The goal is to best capture the elevation of objects.
The indoor missions in the field of cultural heritage are to complete the HBIM from inside when the TLS and other MLS methods are not applicable. Recent case studies with the use of drones for visual inspection in enclosed spaces such as mine galleries, cisterns, or sewers are reported in [18]. In the case of indoor scanning missions, the drone does not benefit from GNNS services, that is, GPS signal for positioning; however, piloting the drone is done in P (positioning) mode when the vision systems to locate and stabilize itself and obstacle sensing function is enabled. Other indoor scanning purposes require drones hovering over the artifacts in order to capture the best image possible. In these conditions, hovering accuracy is the feature that counts, and the best results are obtained by piloting the drone in T-mode (Tripod), which makes the aircraft more stable during the shooting. An example for this use case is the inspection of the roman mosaic arts in Constanta during the expertise for restoration. This is the subject of nondestructive analysis by evaluation of the morphological and chromatic characteristics that represent suitable metrics for making decisions based on image processing [19]. Figure 4 presents this artifact in the present condition of conservation. For a reliable analysis, quality imaging data obtained by correct photogrammetry techniques are required. Thus, for correct analysis, the images of the mosaic, as a primary source of data, must meet certain conditions from the acquisition phase, as follows: (i) to be taken orthographic shots, (ii) to be captured under uniform lighting conditions, without shadows, reflections, etc., (iii) to be taken from the same height (constant distance) for the entire interest surface, and (iv) the resolution must be as high as possible. In general, the photogrammetric method is sufficient for the inspection of artifacts such as flat decorative surfaces, so that 2D orthogonal images obtained by single shots provide all the planimetry and color information necessary for morphological and chromatic analysis. Using CRP with SfM techniques, it is possible to obtain details for DTM by estimating the deformations of the mosaic surface, the degree of degradation by erosion, and the lack of mosaic elements or the degree of intervention by adding material. ALS is not an option for scanning the decorative mosaic because an acceptable value of the GSD parameter cannot be achieved. Also, due to the restriction of access on the surface of the mosaic, scanning by terrestrial means is not possible in this case. In Figure 5, it can be seen two shots taken manually at the arbitrary angle but also the effect of non-uniform environmental lighting.
Ancient mosaic art in Constanta. (a) Indoor floor view. (b) Details of the artifact.
Different images of the artifact.
Professional drones are actually considered UAS (Unmanned Aerial Systems), which means more than an unmanned aerial vehicle. They are equipped with specific scanning systems that define their role and operational functions. The drone is a sufficiently stable platform for close-range photogrammetry (CRP) missions and is an excellent indoor scanning device due to its small size, good maneuverability, and flight qualities. We see great potential for the use of drones for interior photogrammetry on decorative artifacts where the information of interest concerns their planimetry and chromatics. The ease of use of airborne cameras in terms of gimbal stabilizer-controlled mobility, controlled focusing, and exposure function combined with the drone’s ability to hover at a short distance from the artifact gives drones high versatility for digital image acquisition. By using the auto exposure bracketing (AEB) function, for example, the camera can take several successive photos (usually three) with slightly different settings. Then, the images can be combined automatically, for example, in a single image with a high dynamic level or can be stored separately, so that the images with the most suitable appearance can be later taken from the batch.
Regarding the digitization of cultural heritage objectives, the main data are obtained through photogrammetric techniques, which in most cases cannot be exceeded in terms of accuracy and amount of data provided by LiDAR techniques. Moreover, the chromatic analysis of images can be performed exclusively by photographic techniques. Laser scanning techniques have several strengths that make them rather useful as complementary methods in digitizing cultural heritage objectives. Thus, the ALS technique generally helps in the case of infrastructures covered with vegetation and in the case of noisy photographic images when the estimation of the 3D model would be deficient.
Professional drones are becoming increasingly affordable handy tools for use in the field of material cultural heritage.
This study was supported by the grant PN-III-P1-1.2-PCCDI-2017-0476, no.51PCCDI/2018, from UEFISCDI-MEN.
The Internet has irrevocably changed the dynamics of scholarly communication and publishing. Consequently, we find it necessary to indicate, unambiguously, our definition of what we consider to be a published scientific work.
",metaTitle:"Prior Publication Policy",metaDescription:"Prior Publication Policy",metaKeywords:null,canonicalURL:"/page/prior-publication-policy",contentRaw:'[{"type":"htmlEditorComponent","content":"A significant number of working papers, early drafts, and similar work in progress are openly shared online between members of the scientific community. It has become common to announce one’s own research on a personal website or a blog to gather comments and suggestions from other researchers. Such works and online postings are, indeed, published in the sense that they are made publicly available. However, this does not mean that if submitted for publication by IntechOpen they are not original works. We differentiate between reviewed and non-reviewed works when determining whether a work is original and has been published in a scholarly sense or not.
\\n\\nThe significance of Peer Review cannot be overstated when it comes to defining, in our terms, what constitutes a published scientific work. Peer Review is widely considered to be the cornerstone of modern publishing processes and the key value-adding contribution to a scholarly manuscript that a publisher can make.
\\n\\nOther than the issue of originality, research misconduct is another major issue that all publishers have to address. IntechOpen’s Retraction & Correction Policy and various publication ethics guidelines identify both redundant publication and (self)plagiarism to fall within the definition of research misconduct, thus constituting grounds for rejection or the issue of a Retraction if the work has already been published.
\\n\\nIn order to facilitate the tracking of a manuscript’s publishing history and its development from its earliest draft to the manuscript submitted, we encourage Authors to disclose any instances of a manuscript’s prior publication, whether it be through a conference presentation, a newspaper article, a working paper publicly available in a repository or a blog post.
\\n\\nA note to the Academic Editor containing detailed information about a submitted manuscript’s previous public availability is the preferred means of reporting prior publication. This helps us determine if there are any earlier versions of a manuscript that should be disclosed to our readers or if any of those earlier versions should be cited and listed in a manuscript’s references.
\\n\\nSome basic information about the editorial treatment of different varieties of prior publication is laid out below:
\\n\\n1. CONFERENCE PAPERS & PRESENTATIONS
\\n\\nGiven that conference papers and presentations generally pass through some sort of peer or editorial review, we consider them to be published in the accepted scholarly sense, particularly if they are published as a part of conference proceedings.
\\n\\nAll submitted manuscripts originating from a previously published conference paper must contain at least 50% of new original content to be accepted for review and considered for publication.
\\n\\nAuthors are required to report any links their manuscript might have with their earlier conference papers and presentations in a note to the Academic Editor, as well as in the manuscript itself. Additionally, Authors should obtain any necessary permissions from the publisher of their conference paper if copyright transfer occurred during the publishing process. Failure to do so may prevent Us from publishing an otherwise worthy work.
\\n\\n2. NEWSPAPER & MAGAZINE ARTICLES
\\n\\nNewspaper and magazine articles usually do not pass through any extensive peer or editorial review and we do not consider them to be published in the scholarly sense. Articles appearing in newspapers and magazines rarely possess the depth and structure characteristic of scholarly articles.
\\n\\nSubmitted manuscripts stemming from a previous newspaper or magazine article will be accepted for review and considered for publication. However, Authors are strongly advised to report any such publication in an accompanying note to the External Editor.
\\n\\nAs with the conference papers and presentations, Authors should obtain any necessary permissions from the newspaper or magazine that published the work, and indicate that they have done so in a note to the External Editor.
\\n\\n3. GREY LITERATURE
\\n\\nWhite papers, working papers, technical reports and all other forms of papers which fall within the scope of the ‘Luxembourg definition’ of grey literature do not pass through any extensive peer or editorial review and we do not consider them to be published in the scholarly sense.
\\n\\nAlthough such papers are regularly made publicly available via personal websites and institutional repositories, their general purpose is to gather comments and feedback from Authors’ colleagues in order to further improve a manuscript intended for future publication.
\\n\\nWhen submitting their work, Authors are required to disclose the existence of any publicly available earlier drafts in a note to the Academic Editor. In cases where earlier drafts of the submitted version of the manuscript are publicly available, any overlap between the versions will generally not be considered an instance of self-plagiarism.
\\n\\n4. SOCIAL MEDIA, BLOG & MESSAGE BOARD POSTINGS
\\n\\nWe feel that social media, blogs and message boards are generally used with the same intention as grey literature, to formulate ideas for a manuscript and gather early feedback from like-minded researchers in order to improve a particular piece of work before submitting it for publication. Therefore, we do not consider such internet postings to be publication in the scholarly sense.
\\n\\nNevertheless, Authors are encouraged to disclose the existence of any internet postings in which they outline and describe their research or posted passages of their manuscripts in a note to the Academic Editor. Please note that we will not strictly enforce this request in the same way that we would instructions we consider to be part of our conditions of acceptance for publication. We understand that it may be difficult to keep track of all one’s internet postings in which the researcher´s current work might be mentioned.
\\n\\nIn cases where there is any overlap between the Author´s submitted manuscript and related internet postings, we will generally not consider it to be an instance of self-plagiarism. This also holds true for any co-Author as well.
\\n\\nFor more information on this policy please contact permissions@intechopen.com.
\\n\\nPolicy last updated: 2017-03-20
\\n"}]'},components:[{type:"htmlEditorComponent",content:'A significant number of working papers, early drafts, and similar work in progress are openly shared online between members of the scientific community. It has become common to announce one’s own research on a personal website or a blog to gather comments and suggestions from other researchers. Such works and online postings are, indeed, published in the sense that they are made publicly available. However, this does not mean that if submitted for publication by IntechOpen they are not original works. We differentiate between reviewed and non-reviewed works when determining whether a work is original and has been published in a scholarly sense or not.
\n\nThe significance of Peer Review cannot be overstated when it comes to defining, in our terms, what constitutes a published scientific work. Peer Review is widely considered to be the cornerstone of modern publishing processes and the key value-adding contribution to a scholarly manuscript that a publisher can make.
\n\nOther than the issue of originality, research misconduct is another major issue that all publishers have to address. IntechOpen’s Retraction & Correction Policy and various publication ethics guidelines identify both redundant publication and (self)plagiarism to fall within the definition of research misconduct, thus constituting grounds for rejection or the issue of a Retraction if the work has already been published.
\n\nIn order to facilitate the tracking of a manuscript’s publishing history and its development from its earliest draft to the manuscript submitted, we encourage Authors to disclose any instances of a manuscript’s prior publication, whether it be through a conference presentation, a newspaper article, a working paper publicly available in a repository or a blog post.
\n\nA note to the Academic Editor containing detailed information about a submitted manuscript’s previous public availability is the preferred means of reporting prior publication. This helps us determine if there are any earlier versions of a manuscript that should be disclosed to our readers or if any of those earlier versions should be cited and listed in a manuscript’s references.
\n\nSome basic information about the editorial treatment of different varieties of prior publication is laid out below:
\n\n1. CONFERENCE PAPERS & PRESENTATIONS
\n\nGiven that conference papers and presentations generally pass through some sort of peer or editorial review, we consider them to be published in the accepted scholarly sense, particularly if they are published as a part of conference proceedings.
\n\nAll submitted manuscripts originating from a previously published conference paper must contain at least 50% of new original content to be accepted for review and considered for publication.
\n\nAuthors are required to report any links their manuscript might have with their earlier conference papers and presentations in a note to the Academic Editor, as well as in the manuscript itself. Additionally, Authors should obtain any necessary permissions from the publisher of their conference paper if copyright transfer occurred during the publishing process. Failure to do so may prevent Us from publishing an otherwise worthy work.
\n\n2. NEWSPAPER & MAGAZINE ARTICLES
\n\nNewspaper and magazine articles usually do not pass through any extensive peer or editorial review and we do not consider them to be published in the scholarly sense. Articles appearing in newspapers and magazines rarely possess the depth and structure characteristic of scholarly articles.
\n\nSubmitted manuscripts stemming from a previous newspaper or magazine article will be accepted for review and considered for publication. However, Authors are strongly advised to report any such publication in an accompanying note to the External Editor.
\n\nAs with the conference papers and presentations, Authors should obtain any necessary permissions from the newspaper or magazine that published the work, and indicate that they have done so in a note to the External Editor.
\n\n3. GREY LITERATURE
\n\nWhite papers, working papers, technical reports and all other forms of papers which fall within the scope of the ‘Luxembourg definition’ of grey literature do not pass through any extensive peer or editorial review and we do not consider them to be published in the scholarly sense.
\n\nAlthough such papers are regularly made publicly available via personal websites and institutional repositories, their general purpose is to gather comments and feedback from Authors’ colleagues in order to further improve a manuscript intended for future publication.
\n\nWhen submitting their work, Authors are required to disclose the existence of any publicly available earlier drafts in a note to the Academic Editor. In cases where earlier drafts of the submitted version of the manuscript are publicly available, any overlap between the versions will generally not be considered an instance of self-plagiarism.
\n\n4. SOCIAL MEDIA, BLOG & MESSAGE BOARD POSTINGS
\n\nWe feel that social media, blogs and message boards are generally used with the same intention as grey literature, to formulate ideas for a manuscript and gather early feedback from like-minded researchers in order to improve a particular piece of work before submitting it for publication. Therefore, we do not consider such internet postings to be publication in the scholarly sense.
\n\nNevertheless, Authors are encouraged to disclose the existence of any internet postings in which they outline and describe their research or posted passages of their manuscripts in a note to the Academic Editor. Please note that we will not strictly enforce this request in the same way that we would instructions we consider to be part of our conditions of acceptance for publication. We understand that it may be difficult to keep track of all one’s internet postings in which the researcher´s current work might be mentioned.
\n\nIn cases where there is any overlap between the Author´s submitted manuscript and related internet postings, we will generally not consider it to be an instance of self-plagiarism. This also holds true for any co-Author as well.
\n\nFor more information on this policy please contact permissions@intechopen.com.
\n\nPolicy last updated: 2017-03-20
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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The combination of public policies with biotechnological development represents an important indicator for the implementation of sustainable production chains that adhere to the Sustainable Development Objectives (SDO). The ceramic industries in the Amazon region represent activities that promote local economic development through the use of biological resources that can be transformed into bioproducts that are considered a reference for sustainable production in world markets. The operations of these industries have great potential to incorporate technologies that can be used for fabrication of ceramic products on a biological base that is compatible with bioeconomic guidelines. The principle of a bioeconomy is centered on the possibility of transformation of natural resources into bioproducts that aggregate technologies and contribute to increase incomes and reduce environmental impacts. In this way, the integration of different fields of science should be stimulated to incorporate new technologies that favor business models that comply with the premises of sustainability.",book:{id:"10248",slug:"ecosystem-and-biodiversity-of-amazonia",title:"Ecosystem and Biodiversity of Amazonia",fullTitle:"Ecosystem and Biodiversity of Amazonia"},signatures:"Gelson Dias Florentino, Lucieta Guerreiro Martorano, Sandro Augusto Lima dos Santos, José Reinaldo da Silva Cabral de Moraes, Ires Paula de Andrade Miranda and Maria de Lourdes Pinheiro Ruivo",authors:[{id:"78933",title:"Dr.",name:"Maria",middleName:null,surname:"De Lourdes Pinheiro Ruivo",slug:"maria-de-lourdes-pinheiro-ruivo",fullName:"Maria De Lourdes Pinheiro Ruivo"},{id:"252816",title:"Dr.",name:"Lucieta Guerreiro",middleName:"G.",surname:"Martorano",slug:"lucieta-guerreiro-martorano",fullName:"Lucieta Guerreiro Martorano"},{id:"264502",title:"MSc.",name:"José Reinaldo Da Silva Cabral De",middleName:null,surname:"Moraes",slug:"jose-reinaldo-da-silva-cabral-de-moraes",fullName:"José Reinaldo Da Silva Cabral De Moraes"},{id:"326256",title:"Prof.",name:"Gelson Dias",middleName:"Dias",surname:"Florentino",slug:"gelson-dias-florentino",fullName:"Gelson Dias Florentino"},{id:"326424",title:"Mr.",name:"Sandro Augusto",middleName:null,surname:"Lima dos Santos",slug:"sandro-augusto-lima-dos-santos",fullName:"Sandro Augusto Lima dos Santos"},{id:"326427",title:"Dr.",name:"Ires Paula",middleName:null,surname:"de Andrade Miranda",slug:"ires-paula-de-andrade-miranda",fullName:"Ires Paula de Andrade Miranda"}]}],onlineFirstChaptersFilter:{topicId:"331",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. His research interests include optimization, computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, and intelligent systems. Prof. Sarfraz has been a keynote/invited speaker at various platforms around the globe. He has advised/supervised more than 110 students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He has authored and/or edited around seventy books. Prof. Sarfraz is a member of various professional societies. He is a chair and member of international advisory committees and organizing committees of numerous international conferences. He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 15th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:286,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/57054",hash:"",query:{},params:{id:"57054"},fullPath:"/chapters/57054",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()