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1. Introduction
With quickly changing market structures of the Commonwealth of Independent States (CIS) (from centrally planned economies to open markets), privatization and concentration of supply chain actors (especially in the processing and retailing sectors), an understanding of market functioning has drawn considerable attention by the general public (consumers), market players (supply chain members), and policy makers.
Recent global agricultural price fluctuations, so called “commodity price peaks” together with geopolitical developments, e.g., creation of the Eurasian Economic Union in May 2014, and its enlargement since January 2015, and the Russian agricultural import ban imposed in August 2014, considerably affected trade relations of the Former Soviet Union/CIS countries not only within the region but also with the rest of the world and had significant effects on the domestic food prices. All these developments put food prices at the top of political agendas around the world and especially in CIS countries. While an extreme increase in commodity prices usually represents a trigger for a surge in consumer prices, commodity price falls are not necessarily reflected in immediate decreases in consumer prices. Thus, understanding the price transmission mechanisms along the supply chain (i.e., between different members of the supply chain) is crucial for setting an adequate agricultural policy which will allow most market participants to benefit from a sustainable distribution of value added along the supply chain [1].
Agricultural supply chains link agricultural producers with food end consumers via the processing food industry and the food-distributing retailers (Figure 1). This study focuses on the supply chain stage of agricultural production of the farmers. Following a price transmission approach, we investigate market integration and efficiency in agricultural supply chains in the CIS countries. To what degree are price shocks transmitted between the regions and from the world market to the domestic markets? Well-functioning and efficient markets are characterized by strong integration, which could contribute to cushion price-increasing effects of regional production shortfalls and prevent that prices increase beyond world market prices.
Figure 1.
Research scope. Source: own illustration.
Generally, a unique concept of market integration and efficiency does not exist [2]. In this chapter, we assume that a well-functioning market is a spatially efficient market which is characterized by strong market integration. Thus, price shocks in one region are quickly transmitted to the other regions inducing interregional trade flows when price differences exceed trade costs [2]. Also, regional prices differ at most by the costs of trade between those regions (Law of One Price), and profitable opportunities for trade arbitrage do not persist. Further, an efficient market is characterized by adequate trade costs, which are determined by many factors, e.g., distance to other markets, quality and quantity of transport and communication infrastructure, corruption, market risk, and legal barriers as phytosanitary license and inspection requirements [3].
We investigate agricultural supply chains in countries of the former Soviet Union which are linked to neighboring countries or even the world market1 by agricultural imports and exports. Thus, we follow a comparative approach including five different agricultural commodities (i.e., wheat, pork, beef, poultry, and milk) and eight countries of the CIS region (i.e., Armenia, Azerbaijan, Belarus, Georgia, Kazakhstan, Moldova, Russia, and Ukraine). To allow comparability, we apply a uniform method to the comparable sample of data of the same frequency and period of analysis. Data availability on agricultural prices in the CIS countries is very limited which explains the existence of a research gap. Among the few exceptions are Ref. [4] on Georgian bread, sugar, beef and pork markets, and Ref. [5] on the wheat flour market in Georgia.
The remainder of this chapter is organized as follows: in Section 2, we present our methodological approach and the data used in our analysis. Section 3 presents the agricultural trade characteristics of the CIS countries. Empirical results are presented in Section 4, while the primary determinants of market integration are discussed in Section 5. Conclusions are drawn in Section 6.
2. Methodological approach and data
We analyze spatial transmission of different agricultural and food prices between various CIS countries and between CIS countries and the world market. Specifically, we focus on wheat, meat (beef, pork, and poultry), and milk in eight CIS countries in the region. An overview on the countries included in our analysis is presented in Appendix.
We analyze on the integration of agricultural markets in CIS countries with their regional trade partners within the CIS region but also with the EU market and the world market. We evaluate the integration of domestic CIS markets with the export markets in other CIS countries within the region. We also examine how price changes from the EU market and international markets are transmitted to the domestic markets in the CIS region.
Focusing on the bivariate price transmission model, we characterize long-run dynamics between price pairs consisting of a domestic price of one of the CIS countries and a world market price (or price of some CIS exporting country).2 We refer to a domestic market as fully integrated in the world market, if price changes on the world market are completely transmitted to the domestic market. A long-run price equilibrium is given as
Ptd=α+βPtw+εtE1
where Ptd and Ptw are natural logarithm of domestic and world market prices at time t espectively,the intercept parameter α,the slope parameter β, and the residual εt denoting the stationary disturbance term. The long-run price transmission parameter β indicates the degree (in %) to which price changes on the world market are transmitted to the domestic market. Perfect market integration is given if β = 1, implying that a 1% price change on the world market is transmitted by 100% to the domestic market, leading to a 1% price change on the domestic market.
We apply the augmented Dickey-Fuller (ADF) test [6] to test on stationarity of our data series. We test for cointegration between the non-stationary price series using the Johansen test of linear cointegration [7]. In case, we find domestic and world market prices cointegrated, the Ordinary least squares (OLS) regression yields consistent and efficient estimates of the long-run equilibrium parameters [8].
As already mentioned above, data availability is one of the most critical issues when it comes to research on food markets in the CIS countries. In this study, we have created a unique data set for selected food products by combining different data sources, ranging from statistical offices of the respective CIS countries, via different country reports published by various international institutions (e.g., WB, FAO, and OECD), all the way to expert interviews. According to data availability, we are able to conduct the analysis for wheat, meat (pork, beef, and poultry), and milk (i.e., milk powder) markets of all eight selected CIS countries.
Concerning wheat prices, we use producer, import, and export prices of wheat in different countries. Data are sorted into two groups. The first group refers to Armenia, Azerbaijan, Georgia, Ukraine, and Moldova where we use average producer wheat prices. Since domestic producer prices for wheat in Georgia are not available, we use the cost, insurance, and freight (i.e., CIF) import price. The second group consists of the Customs Union members, i.e., Russia, Kazakhstan, and Belarus. Considering that Russia and Kazakhstan are, besides Ukraine, the main wheat exporters not only to the CIS region but also to the world market as well, in addition to average producer prices, we also account for their free on board (i.e., FOB) export prices observed at the Black Sea harbors. For Belarus, we use the governmentally fixed wheat purchase prices. We use average French FOB price at the port of Rouen (representative price for the Marché à Terme International de France (MATIF) commodity futures market in Europe) as a measure for the EU market price. Average FOB soft red winter wheat prices of the USA serve as representative for the world market price. The time period covered by our data set ranges from 2006 until 2014 and differs between countries and products. Thus, the number of observations varies between 74 (for Moldova) and 130 (for Belarus).
Our data set comprises pork prices for Armenia, Georgia, Belarus, Kazakhstan, Russia, and Ukraine. In addition, we consider pork prices for the EU, Brazil, and USA, which are some of the most important pork exporters to the CIS countries. Denmark, Germany, and Spain together have exported more than 50% of total EU pork export to the CIS in 2013. Our data set contains two types of pork prices. First, for Ukraine, we account for producer prices, which refer to the price paid for 1 kg of live animal. Second, we account for the producer price for 1 kg of deadweight for all other countries. The conversion of the prices between 1 kg of live animal and deadweight is done by using the conversion rate of 0.59 for Ukraine [9]. Our data set covers the period from January 2004 until December 2014. The number of observations differs between countries, from 45 observations for Ukraine to 132 observations for Armenia, Russia, EU, and USA.
As was the case for pork, we account for beef prices for Armenia, Georgia, Russia, Kazakhstan, Belarus, and Ukraine. For the EU, we use the EU average beef price. For the world price, we focus on beef prices of USA, Brazil, Uruguay, Argentina, and Australia, which are directly involved in beef export to CIS countries. Our data set covers the period from January 2004 until December 2014. The number of observations differs between countries, from 45 observations for Ukraine to 132 observations for Armenia, Russia, EU, and USA.
Due to very limited data availability for poultry, only Georgia as a representative for the Caucasian countries is covered by our analysis. For the EU price, we account for both EU average and country-specific average poultry prices. Here, we selected Netherlands and Germany as two of the most important EU exporters of poultry meat to CIS countries. The data set covers a period from January 2004 until December 2014. The number of observations differs between countries, from 45 observations for Ukraine to 132 observations for Russia.
The milk prices used for the analysis are average monthly milk producer prices. For the selected international markets, we use EU whole milk powder (WMP) export prices and FOB Oceania WMP prices. In addition, we use domestic WMP prices for Netherlands and Germany, countries that are the largest EU WMP exporters to the CIS countries accounting for 21 and 16% of the total CIS import, respectively. To compare the fluid milk producer prices of CIS countries with the WMP prices of the selected international markets, we transform the fluid milk prices into WMP prices using conversion factors obtained by the national experts of the selected CIS countries [10]. Thus, for Armenia, we use a conversion factor of 7.5, for Belarus 7.3, for Kazakhstan 7.5, For Russia 7, and for Ukraine 8.3. Our data set covers a period from January 2004 to December 2013. As in previous cases, the number of observations differs between the countries, ranging from 36 observations for Ukraine to 106 observations for most other countries.
Overall, considering that most of the agricultural trade of the CIS countries is done in US Dollars (USD), prices in domestic currencies are converted in USD. Thus, all prices used for the analysis refer to USD per measurement unit.
3. Agricultural trade of the CIS countries
In the following, we provide an overview on agricultural trade of the CIS trade regarding wheat, pork, beef, poultry, and milk which provides the basis for the interpretation of our empirical results in Section 4.
Wheat production and trade are of a great importance for the CIS countries. From one side, Russia, Ukraine, and Kazakhstan are becoming large wheat exporters that are important not only for the CIS region but also for the international markets. This is especially the case for Russia that became the largest wheat exporter in the world in 2016 of about 40 million ton. On the other side, Caucasian countries (i.e., Armenia, Azerbaijan, and Georgia) import more than 90% of wheat from the CIS region, notably from Russia and Kazakhstan [11]. From the regional perspective, Russian wheat is the most important for domestic consumption, and its quality is usually improved by imports of the high-quality Kazakh wheat. This is mainly the case for Caucasian countries. Nevertheless, Kazakh wheat is almost the only source of wheat for some Central Asian countries (i.e., Uzbekistan, Tajikistan, and Kyrgyzstan). Besides mentioned wheat exporting and importing CIS countries, Belarus and Moldova produce a sufficient amount of wheat for domestic production but are not large wheat exporters.
All the selected CIS countries are net pork importers. The EU (27) is the largest supplier of pork to the CIS countries with a share of 56% (in 2013). Only about 2% of pork is traded regionally, where the main exporters are Moldova, Belarus, Russia, and Kazakhstan. Significant market changes are recorded for the members of the Customs Union, where each member country is supposed to adjust their meat import tariff according to the Union’s common trade policy. This was particularly important for Kazakhstan, which did not have any significant internal market protection before [12]. Nevertheless, most of the selected CIS countries have a higher level of price protection for pork compared to other products [13].
In comparison with pork, CIS beef markets are considerably different. Namely, Caucasian countries (i.e., Armenia, Azerbaijan, and Georgia) are net beef importers. The same is true for Russia and Kazakhstan. About 89% of beef is imported from some of the international markets (excluding EU (27)). Only about 8% is imported from some of the CIS countries. On the other hand, the main beef exporting CIS countries are Belarus, Moldova, and Ukraine. Overall, beef is one of the products that have the smallest level of price protection among CIS countries [13].
Similar to the CIS beef markets, some of the CIS countries are net importers, and some are net poultry exporters. Concerning imports, about 17% is imported from the EU (27) markets, 22% from other CIS countries, and 61% from other international markets (in 2013, [14]). The net importing countries are Armenia, Azerbaijan, Georgia, Moldova, Russia, and Kazakhstan. On the other side, some of the net importers also engage in poultry export but mainly on the regional markets. The only two net exporting countries are Belarus and Ukraine. As is the case with pork, poultry also has high level of price protection among CIS countries [13].
Almost half of the total dairy products imported to the selected CIS countries originate from the region. Namely, 47% of total diary imports originate from some of the CIS countries, where Belarus, Russia, and Ukraine are the largest regional exporters. On the other hand, about 44% of the total CIS dairy imports originate from the EU, where Netherlands, Germany, and Finland represent the largest exporters, covering 50% of the EU exports to CIS countries. Only about 9% of dairy products are imported from some of the world markets (excluding CIS and EU). Concerning milk, it is mainly imported in the form of a milk powder. About 65% of total milk powder imports by the CIS countries originate from Belarus and Ukraine, which are net exporters. Further, about 23% of milk powder is imported from EU (27) markets.
4. Empirical results
Empirical results are presented for each of the five agricultural products individually. Besides the comparison of average price levels between countries, we provide a detailed overview on the pattern of market integration for each product. Market integration for the different agricultural products is analyzed on an aggregated level for the CIS countries on average and on a disaggregated level for individual countries. Market integration of the CIS countries is investigated regarding their regional integration in the CIS, the integration with the EU market and the world market.
4.1. Wheat
Domestic price and trade policies are among most important factors determining domestic price developments. Due to different production and trade characteristics of the CIS countries covered in this study, domestic price developments differ between the selected countries (Figure 2). Thus, wheat prices in Armenia, Azerbaijan, and Georgia, three wheat importing countries, are higher compared to the CIS average. On the other hand, wheat prices in Russia and Ukraine, two large wheat exporters, are on average lower compared to the average CIS prices and selected international prices. The most extreme case is Belarus, where the domestic government keeps wheat prices at an artificially low level to support domestic meat production [15]. Furthermore, wheat producer prices in the whole CIS region were affected by wheat export restrictions imposed by Russia, Ukraine, and Kazakhstan between 2006 and 2012 [16], which ultimately had a strong effect on consumers and overall food security in these countries.
Figure 2.
Average wheat price level in the CIS countries and selected international markets (base: 2011–2013). Source: Statistical offices of the respective CIS countries [17, 18], own illustration.
The analysis of market integration indicates that the CIS wheat markets are strongly integrated within the region (integration between CIS countries) and with the EU (i.e., France) and world markets (i.e., USA; Figure 3). Surprisingly, integration in world wheat markets is highest amounting to about 76%. Regional wheat market integration lies by on average 68%, and integration with the EU wheat market lies by 61%.
Figure 3.
CIS wheat market integration—aggregated level. Source: Own calculation based on the estimation results, own illustration.
Figure 4 provides a detailed overview on the pattern of market integration. On the regional level, Georgia and Moldova are strongest integrated with the other CIS countries (Figure 4). Moderate regional integration is recorded for Armenia and Azerbaijan, countries that are heavily dependent on wheat imports from other CIS countries. A moderate level of integration might indicate certain market inefficiencies, which might be connected to certain market regulations set by the government, for example, in the case of Azerbaijan.
Figure 4.
CIS wheat market integration—disaggregated level. Source: Own calculation based on the results, own illustration.
The integration of the CIS countries within the CIS regional market is very similar to their integration in the EU market and the world market. The main reason is that both markets, EU and world, are used as reference markets for price negotiations in wheat trade by CIS traders. Price discounts or mark-ups might result from quality differences and internal price determining factors. It is striking that the Ukrainian wheat market has stronger integration with world markets compared to the EU. Overall, the Russian, Ukrainian, and Moldavian wheat markets are strongly integrated with both the EU and world markets. These results are in accordance with the trade status of these countries. Namely, Russia and Ukraine are large wheat exporters not only in the CIS region but also on the international level as well. Thus, international price changes have a great impact on their domestic producer prices. On the other hand, Moldova is also an exporting country but with no significant relevance for the regional and international wheat trade. It is interesting to observe that there is almost no integration between Kazakh and international wheat markets. The main reason is that Kazakh wheat export is mainly concentrated on Central and East Asian countries, and thus, Kazakh domestic prices do not react much to price shocks from the “Western” markets.
4.2. Pork
The 3-year pork price averages presented in Figure 5 indicate that the CIS prices are higher than the prices on the EU (i.e., Denmark, Germany, and Spain) and world markets (i.e., Brazil and USA). For the Customs Union members (i.e., Belarus, Russia, and Kazakhstan), we can observe that Russian pork prices are at the level of the CIS average price but by 20 and 11% higher than the average Belarussian and Kazakh prices, respectively. The Belarus price level is not reflecting actual market conditions but is rather the result of the price targeting by the Belarussian government [13].
Figure 5.
Average pork price level in the CIS countries and selected international markets (base: 2011–2013). Source: Statistical offices of the respective CIS countries and [19], own illustration.
The results of the price transmission analysis indicate that the CIS countries are on average well integrated with both regional and international pork markets. The highest integration level is recorded with the EU market where we observe full transmission of price shocks (Figure 6). Besides the EU, regional markets seem to be very well integrated among each other, where about 80% of the price shocks are transmitted in the long run. In particular, regional market integration is very strong between Belarus, Russia, and Kazakhstan. International market price shocks are only by about 50% transmitted to the domestic markets in the CIS countries. Obtained results are in accordance with the CIS pork trade developments where we observe that 56% of the total CIS pork import (for selected CIS countries) originates from the EU.
Figure 6.
CIS pork market integration—aggregated level. Source: Own calculation based on the estimation results, own illustration.
A cross-country comparison of the price transmission results is presented in Figure 7. As already mentioned, our results indicate highest integration of the CIS pork market with the EU. This is certainly the case for Belarus, Russia and Kazakhstan, members of the Customs Union, for which we found full transmission of price shocks from the EU market in the long run. These results are not surprising considering that Belarus, Russia, and Kazakhstan import 98, 59, and 57%, respectively, of their total pork import from the EU. On the other hand, Belarus, Russia, and Kazakhstan have a very low level of integration with other CIS countries. Concerning market integration with the international markets (Figure 7), our results indicate strong integration of Georgian and Armenian pork markets, while Belarus, Russia, and Kazakhstan show very weak integration.
Figure 7.
CIS pork market integration—disaggregated level. Note: Missing marker means no integration with the respective market. Source: Own calculation based on the results, own illustration.
4.3. Beef
The 3-year beef price averages presented in Figure 8 indicate that the average CIS prices are 29% lower than the EU price (i.e., EU average price) but are similar to the price level of the world markets (i.e., Brazil, Uruguay, USA, Argentina, and Australia). Armenia, Russia, and Kazakhstan have the highest beef prices, which are 50, 35, and 20% higher than the CIS average prices, respectively. Our data indicate that Ukraine has relatively low beef prices compared to other CIS countries, the EU and the world market, with the price level about 60% lower than the CIS average. Overall, the data presented in Figure 8 show significant differences in average beef prices between the CIS countries.
Figure 8.
Average beef price level in the CIS countries and selected international markets (base: 2011–2013). Source: Statistical offices of the respective CIS countries and [19], own illustration.
Our price transmission results indicate very strong integration of CIS beef markets both regionally and internationally. We find that price shocks are perfectly transmitted from the EU market and by 88% from the world market to the CIS countries on average. But even regional integration is high amounting to 86% of the CIS on average (Figure 9).
Figure 9.
CIS beef market integration—aggregated level. Source: Own calculation based on the estimation results, own illustration.
The cross-country market integration results on the disaggregated level presented in Figure 10 indicate that Kazakhstan and Belarus are strongly integrated with other regional markets. A moderate level of regional integration is recorded for Russia, while Georgia seems not to be integrated with other regional markets in the long run. Concerning market integration with the EU, our results indicate almost full transmission of price shocks in the long run. In contrast, our results do suggest no market integration of the Ukrainian market with the EU.
Figure 10.
CIS beef market integration—disaggregated level. Note: Missing marker means no integration with the respective market. Source: Own calculation based on the results, own illustration.
4.4. Poultry
The 3-year average poultry prices presented in Figure 11 indicate that the CIS prices are 26% lower than the EU price (i.e., Netherlands and Germany) and are similar to the world market price level (i.e., Brazil and USA). This is especially the case for Georgia, Ukraine, and Kazakhstan, where prices are below the CIS average. In contrast to pork and beef prices, poultry prices are not characterized by a great dispersion for the observed period.
Figure 11.
Average poultry price level in the CIS countries and selected international markets (base: 2011–2013). Source: Statistical offices of the respective CIS countries, own illustration.
Concerning the price transmission analysis, our results indicate that the CIS poultry markets are integrated regionally, with the EU and with selected international poultry markets. Strongest integration is recorded with the EU market, where 73% of the price shocks are transmitted to the domestic CIS markets in the long run (Figure 12). Moderate transmission is recorded from regional markets, while relatively slow transmission is recorded from the selected international markets.
Figure 12.
CIS poultry market integration—aggregated level. Source: Own calculation based on the estimation results, own illustration.
The results from the disaggregated cross-country comparison indicate that the Russian poultry prices are strongly integrated with both regional and EU poultry markets, where we observe almost full transmission of price shocks (Figure 13). However, our results of Ukraine indicate no market integration with regional and EU poultry markets.
Figure 13.
CIS poultry market integration—disaggregated level. Source: Own calculation based on the results, own illustration.
4.5. Milk
For investigating the country-level assessment of CIS milk market integration, we focus on the milk powder prices [i.e., whole milk powder (WMP)] rather than on fluid milk prices.
Figure 14 shows the estimated 3-year WMP price averages for the CIS countries. Compared to selected EU markets (i.e., EU 27 average price, Netherlands, and Germany) and world markets (i.e., Oceania), estimated CIS average prices are by on average 28% lower. The highest WMP prices are recorded for Russia and Kazakhstan (14% above the average), while the lowest prices are recorded for Belarus (27% below the average). Armenian and Ukrainian WMP prices are almost at the level of average CIS WMP prices.
Figure 14.
Average milk price level in the CIS countries and selected international markets (base: 2011–2013). Source: Statistical offices of the respective CIS countries and [18], own illustration.
The price transmission results indicate relatively moderate integration of the CIS WMP markets with both regional and selected international markets (Figure 15). The results from the cross-country comparison indicate that the Kazakh WMP market is strongly integrated with the regional markets, where we observe almost full transmission of price shocks (Figure 16). The Russian WMP market is strongly integrated with the EU market where we also observe almost full transmission of price shocks. Changes from the selected international market (i.e., Oceania) are transmitted to the Russian and Kazakh markets to the higher degree compared to other CIS countries (Figure 16).
Figure 15.
CIS whole milk powder market integration—aggregated level. Source: Own calculation based on the estimation results, own illustration.
Figure 16.
CIS whole milk powder market integration—disaggregated level. Note: Missing marker means no integration with the respective market. Source: Own calculation based on the results, own illustration.
4.6. Summary of market integration results
The results of the price transmission analysis (Figure 17) indicate strongest market integration of the CIS beef market with all three reference markets, i.e., regional CIS, EU, and the world market. As already mentioned, one of the main reasons for almost full transmission of price shocks from reference markets to the domestic CIS markets might be the fact that beef markets in CIS countries have lowest level of price protection compared to other products [13].
Figure 17.
CIS market integration by product. Source: Own calculation and illustration.
The observed strong market integration of the CIS pork markets with the EU market might result from comprehensive pork imports (trade flows) from the EU (until 2014). Similarly, significant pork trade between Belarus, Russia, and Kazakhstan, supported by the removal of trade barriers within the Customs Union, contributed to the rather strong regional pork market integration of the CIS countries.
The strong integration of the CIS wheat markets with the world market is might be explained by two main factors: (1) Russia and Ukraine have advanced to global leaders in wheat trade and thus have a strong influence on world wheat prices; (2) World market prices are used as a benchmark price for regional wheat trade among CIS countries.
Considering that none of the CIS countries is a large poultry and whole milk powder importer or exporter and thus not a significant player on the world market, market integration is lower with the world market compared to EU and CIS regional markets. The EU market prices are used as a benchmark for negotiating poultry and whole milk powder trade between CIS countries.
Overall, all selected CIS markets are well integrated with the EU market due to market proximity and significant trade flows supported by numerous bilateral trade agreements. Integration with world markets is strong for products where CIS markets are large exporters (e.g., for wheat) or importers (e.g., for beef). Regional market integration greatly depends on trade volumes, infrastructure issues, and market barriers (i.e., removal of tariffs within the Customs Union).
5. Determinants of the CIS market integration
Differences in market integration observed between regions or countries might result from the influence of a variety of different factors. In the following, we link major influencing factors, in particular, the level of domestic market support, trade policies, the size of physical trade flows, infrastructure, and bilateral or multilateral trade agreements with our results on market integration of the CIS countries.
First, market support and trade-oriented policy measures have a strong impact on market integration [20]. For markets characterized by a high level of state support, the results indicate moderate or even no integration with international markets. This is especially the case with the CIS pork and poultry markets. On the country level, Belorussian attempts to support livestock production by strongly regulating grain prices is one of the main reasons why the Belorussian wheat market is not integrated with any of the reference markets. On the contrary, CIS markets with almost no state support, such as wheat and beef markets, are strongly integrated with international markets. Besides direct state support, sudden changes in CIS trade policies are significantly affecting CIS market integration. In particular, numerous export-oriented measures (e.g., export bans, export taxes, or export quotas) were implemented on CIS wheat markets in the last decade. The results for Russia and Ukraine indicate that wheat export restrictions significantly decrease the level of market integration and thus the transmission of price changes from international reference markets to domestic markets [21]. Furthermore, the decrease in price transmission is higher for regions within a country that are strongly integrated with international markets when trade is freely possible (e.g., North Caucasus for Russia and Odessa for Ukraine).
Second, the size of physical trade flows and the importance of the reference market for global trade (e.g., US wheat price) play an important role for market integration of the CIS countries. Strong regional integration of the CIS countries is based on the fact that Armenia, Georgia, and Azerbaijan are among the largest CIS wheat importers with wheat imports almost completely originating from other CIS countries (i.e., Russia, Ukraine, and Kazakhstan). At the same time, these countries have strong integration with international markets as well. We argue that price information coming from the main international markets is used by regional CIS traders as a benchmark for negotiating prices in regional trade. Similar considerations could be used for explaining strong market integration between CIS pork markets with regional and EU markets.
Third, underdeveloped infrastructure presents a great obstacle for the market integration of many CIS countries. This is especially visible on a disaggregated country-level analysis. Difficulties to obtain sufficient railway wagons, small capacity of port terminals on the Caspian Sea, and underdeveloped national roads significantly contribute to low market integration of the Kazakh wheat market with international markets. Besides a deficient grain transport infrastructure, large distances between grain producing and consuming regions strongly influence the degree of market integration of different regions in Russia. Infrastructural problems are also one of the main factors influencing market integration of Caucasian countries (i.e., Armenia, Azerbaijan, and Georgia) with the EU and international markets.
Fourth, strengthening trade relations through bilateral or multilateral trade agreements significantly contributes to market integration of the CIS countries. The establishment of the Eurasian Customs Union (EACU) facilitates the trade process between Belarus, Russia, and Kazakhstan. The results indicate that the EACU members have almost identical regional and international levels of integration. This is especially the case for pork markets. In addition, the results indicate strong market integration of CIS pork, beef, poultry, and milk markets with the EU. The main reason for almost full transmission of price shocks from the EU markets might be associated to numerous bilateral trade agreements between the EU and almost all CIS countries.
6. Conclusions
In this chapter, we have analyzed to which extend selected CIS markets are integrated in regional and world agricultural markets.
Based on a unique data set which we have created utilizing a wide variety of different data sources available for the CIS countries, we have conducted the analysis for the wheat, meat (i.e., pork, beef, and poultry), and milk markets. The selected markets represent the most important agricultural sectors of the CIS countries. Well-functioning efficient agricultural markets are essential for food security in the CIS countries and are thus of great interest for policy makers.
The results of the price transmission analysis indicate that regional integration within the CIS is strongest for pork and beef, followed by poultry and whole milk powder. The integration of CIS markets in world agricultural markets is strongest for wheat and beef, whereas it is relatively low for pork and poultry. All in all, beef markets in the CIS countries are the strongest integrated within the region, with the EU and the world market.
Overall, our results indicate that domestic market support and trade policies, physical trade flows between countries, infrastructure, and bilateral or multilateral trade agreements play a key role in market integration of the CIS countries. First, our results indicate that markets characterized by a high level of state support, integration with international markets is weak or even a lack of integration is observed compared to markets where market support measures are absent. Second, our results indicate that CIS markets might be well-integrated with both regional and international markets due to the fact that regional integration is more connected to the physical trade flows (import dependency), while integration with international markets is more based on defining the benchmark price for the products that are traded on the regional level. Third, for most of the CIS countries, underdeveloped infrastructure significantly reduces market integration. Fourth, strengthening trade relations through bilateral or multilateral trade agreements significantly contribute to market integration of the CIS countries. That is especially the case for members of the Eurasian Customs Union and CIS agreements with the EU.
Acknowledgments
Research project supported by the European Commission under the 7th Framework Programme: “Exploring the potential for agricultural and biomass trade in the Commonwealth of Independent States” (www.agricistrade.eu).
Appendix. List and classification of countries
Domestic markets
World regional markets
World reference markets
Countries
CIS
CIS
EU
World
Armenia
x
Azerbaijan
x
Georgiaa
x
Belarus
x
Moldova
x
Kazakhstan
x
x
Russia
x
x
Ukrainea
x
x
France
x
Denmark
x
Germany
x
Netherlands
x
Spain
x
Oceania
x
Brazil
x
Australia
x
Argentina
x
Uruguay
x
USA
x
aAlthough Georgia and Ukraine are no longer CIS members, in this study, we still refer them as CIS countries due to their tight regional trade connections with other CIS members.
\n',keywords:"CIS, agricultural markets, market integration, price transmission",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/56263.pdf",chapterXML:"https://mts.intechopen.com/source/xml/56263.xml",downloadPdfUrl:"/chapter/pdf-download/56263",previewPdfUrl:"/chapter/pdf-preview/56263",totalDownloads:1001,totalViews:176,totalCrossrefCites:3,totalDimensionsCites:3,totalAltmetricsMentions:0,impactScore:3,impactScorePercentile:82,impactScoreQuartile:4,hasAltmetrics:0,dateSubmitted:"October 4th 2016",dateReviewed:"May 23rd 2017",datePrePublished:"December 20th 2017",datePublished:"April 26th 2018",dateFinished:"June 27th 2017",readingETA:"0",abstract:"Utilizing a price transmission approach, we focus on price relationships between the countries of the Commonwealth of Independent States (CIS) and how price changes on the world agricultural market are transmitted to the domestic CIS markets. In this study, we establish a unique price data set on five different agricultural products (i.e. wheat, pork, beef, poultry and whole milk powder) observed in eight different CIS countries. The results of the price transmission analysis indicate that regional integration within the CIS is strongest for pork and beef, followed by poultry and whole milk powder. The integration of CIS markets in world agricultural markets is strongest for wheat and beef, whereas it is relatively low for pork and poultry. Furthermore, beef markets in the CIS countries are the strongest integrated within the region, with the EU and the world market. Overall, our results indicate that domestic market support and trade policies, physical trade flows between countries, infrastructure, and bilateral or multilateral trade agreements play a key role in market integration of the CIS countries. These determinants should be particularly considered when designing recommendations for improving agri-food supply chain competitiveness in the CIS countries.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/56263",risUrl:"/chapter/ris/56263",book:{id:"5762",slug:"agricultural-value-chain"},signatures:"Ivan Djuric, Linde Götz, Miranda Svanidze and Thomas Glauben",authors:[{id:"197133",title:"Dr.",name:"Ivan",middleName:null,surname:"Djuric",fullName:"Ivan Djuric",slug:"ivan-djuric",email:"djuric@iamo.de",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Leibniz Institute of Agricultural Development in Transition Economies",institutionURL:null,country:{name:"Germany"}}},{id:"197272",title:"Dr.",name:"Linde",middleName:null,surname:"Götz",fullName:"Linde Götz",slug:"linde-gotz",email:"goetz@iamo.de",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"197273",title:"MSc.",name:"Miranda",middleName:null,surname:"Svanidze",fullName:"Miranda Svanidze",slug:"miranda-svanidze",email:"svanidze@iamo.de",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"197275",title:"Prof.",name:"Thomas",middleName:null,surname:"Glauben",fullName:"Thomas Glauben",slug:"thomas-glauben",email:"glauben@iamo.de",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Methodological approach and data",level:"1"},{id:"sec_3",title:"3. Agricultural trade of the CIS countries",level:"1"},{id:"sec_4",title:"4. Empirical results",level:"1"},{id:"sec_4_2",title:"4.1. Wheat",level:"2"},{id:"sec_5_2",title:"4.2. Pork",level:"2"},{id:"sec_6_2",title:"4.3. Beef",level:"2"},{id:"sec_7_2",title:"4.4. Poultry",level:"2"},{id:"sec_8_2",title:"4.5. Milk",level:"2"},{id:"sec_9_2",title:"4.6. Summary of market integration results",level:"2"},{id:"sec_11",title:"5. Determinants of the CIS market integration",level:"1"},{id:"sec_12",title:"6. Conclusions",level:"1"},{id:"sec_13",title:"Acknowledgments",level:"1"},{id:"sec_13",title:"Appendix. List and classification of countries",level:"1"}],chapterReferences:[{id:"B1",body:'European Commission. Analysis of price transmission along the food supply chain in the EU. Accompanying document to the communication from the Commission to the European Parliament, the Council, the European economic and social committee and the committee of the regions. Commission of the European communities, Commission stuff working document SEC 1450, Brussels, 28.10.2009 http://groupedebruges.eu/sites/default/files/publications/downloads/publication16067_price_transmission_ec.pdf'},{id:"B2",body:'Fackler P, Goodwin B. Spatial price analysis. In: Gardner B, Rausser G, editors. Handbook of Agricultural Economics. Vol. 1B. Amsterdam: Elsevier; pp. 971-1024. DOI: 10.1016/s1574-0072(01)10025-3.ch17'},{id:"B3",body:'Tomek W, Robinson K. Agricultural Product Prices. 4th ed. Cornell Universtiy Press, Ithaca, New York, United States of America; 2003. ISBN-13: 978-0-8014-5230-7'},{id:"B4",body:'Bluashvili A, Safaryan S. Global food price shocks transmission to local markets and welfare implications for Georgian households. Policy Paper 2014. 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CABI (Commonwealth Agricultural Bureaux (CAB) International), Wallingford, Oxfordshire, United Kingdom; 2015. pp. 191-203. DOI: 10.1079/9781780645353.0000.ch19'},{id:"B17",body:'APK-Inform. AgriNews, various issues. Available from: https://www.apk-inform.com/en. 2016'},{id:"B18",body:'United States Department of Agriculture (USDA). Available from: http://apps.fas.usda.gov/psdonline/psdquery.aspx. 2016'},{id:"B19",body:'Irish Food Board. Available from: www.bordbia.ie. 2016'},{id:"B20",body:'Djuric I, Götz L. Export restrictions – Do consumers really benefit? The wheat-to-bread supply chain in Serbia. Food Policy. 2016;63:112-123. DOI: 10.1016/j.foodpol.2016.07.002'},{id:"B21",body:'Götz L, Djuric I, Nivievskyi O. Regional price effects of extreme weather events and wheat export controls in Russia and Ukraine. Journal of Agricultural Economics 2016;67(3):741-763. DOI: 10.1111/1477-9552.12167'}],footnotes:[{id:"fn1",explanation:"We use “world market” and “international market” interchangeably in this article."},{id:"fn2",explanation:"For the simplicity we keep the term world market price for describing the long-run price equilibrium."}],contributors:[{corresp:"yes",contributorFullName:"Ivan Djuric",address:"djuric@iamo.de",affiliation:'
Leibniz Institute of Agricultural Development in Transition Economies, Halle (Saale), Germany
Leibniz Institute of Agricultural Development in Transition Economies, Halle (Saale), Germany
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1. Introduction
Intraoperative hemostasis is primarily achieved through knowledge of anatomy and good surgical technique. Technology has augmented the basic tenets of surgical hemostasis since 1926 and has continued to evolve. In addition to applying pressure and using suture, there are now a wide variety of hemostatic options available to gynecologic surgeons including monopolar/bipolar cautery, harmonic technology, hemoclips, laser, argon beam coagulation, tacks, and topical hemostatic agents. Like any other trade, it is important to have the right tool for the job. If there is bleeding in a sensitive anatomic location in the pelvis, mechanical and thermal techniques may not be practical given the risk to adjacent tissues. Topical hemostatic agents have been available since the mid 20th century and can act as an adjunct to provide both active and passive hemostasis in situations where bleeding is difficult or impractical to be controlled by conventional methods. Topical hemostatic agents work by augmenting specific parts of physiologic hemostasis. Of the four phases of hemostasis [1, 2], topical hemostatic agents primarily affect formation of the platelet plug and propagation of the coagulation cascade. Topical hemostatic agent use is common practice in many surgical procedures, and has been utilized across all surgical specialties [3]. Likely due to marketing, usage of topical hemostatic agents has increased by 10–21% since 2000 [4]. This chapter will focus on use of topical hemostatic agents in obstetrics/gynecological surgeries with a focus on postpartum hemorrhage, myomectomy, hysterectomy, endometriosis surgery, oncologic debulking, and ovarian cystectomy.
2. Hemostatic mechanisms
In order to understand the mechanism of action of topical hemostatic agents, it is important to understand the basic physiology of hemostasis. There are four main phases of hemostasis: endothelial injury and platelet plug formation, activation of the clotting cascade, termination of the clotting, and fibrinolysis [3]. Hemostasis represents a delicate and regulated balance between thrombosis and thrombolysis. Formation of a stable hemostatic clot relies on a complex interaction between vasoconstriction, circulating clotting factors, and platelet factors. In a surgical patient, the inciting event is endothelial damage from trauma. Injury to the endothelium exposes blood to subendothelial elements that promote platelet adhesion and activation. Endothelial injury also activates both the extrinsic and intrinsic coagulation pathways through increased expression of tissue factor and exposure to negatively charged surfaces respectively.
After vessel injury, there is temporary vasoconstriction which facilitates platelet adhesion and subsequent activation. This forms a fragile platelet plug which requires stabilization during secondary hemostasis to form a clot. Initiation of the coagulation cascade occurs through both extrinsic and intrinsic pathways. This involves multiple plasma proteins, calcium ions, and platelets. At the end of the cascade, thrombin ultimately converts fibrinogen to fibrin leading to a stable clot [5]. This is critical as thrombin can be applied alone or in combination with other hemostatic agents, bypassing the intrinsic and extrinsic pathways as long as there is adequate circulating fibrinogen present.
3. Hemostatic agents
There are four sub-categories of hemostatic agents utilized. These include mechanical, biological, flowable, and fibrin sealant. They each have different properties and associated cost [6]. Although there are different mechanisms of action, these topical hemostatic agents act by augmenting the first phase of coagulation (platelet plug formation) and/or stimulating the production of fibrin for clot stabilization. Agents that both stimulate platelet plug formation and contain thrombin are the most effective at creating hemostasis but are the most costly. Table 1 provides a summary of the agents discussed in this chapter. The four sub-categories of hemostatic agents will be discussed individually followed by their usage in common obstetric/gynecologic procedures.
Difficult to handle, Granuloma formation, infection
$$
Microporous Polysaccharide spheres
Plant
Powder
Arista, Vitasure, Hemostase
Absorbs water to concentrate platelets and accelerate clot formation
< 48 hours
Can alter glucose loads in diabetic patient if used excessively
$
Fibrin Sealants⋄
Pooled human plasma, Pooled human and equine collagen, Individual human plasma with bovine collagen and thrombin
Liquid
Tisseel, Evicel, Tachosil, Vitagel
Contain high levels of fibrinogen and thrombin separately that when combined form a fibrin clot at an accelerated speed
Immediate
Potential exposure to blood borne viruses
$$$
Table 1.
Biologic hemostatic agents.
Severe hypersensitivity reactions and antibody formation can occur with use of protein-containing topical hemostatic and fibrin sealants; more evident with repeated application.
Price range (US dollars): $:50 to 100 dollars, $$ 101 to 300 dollars, $$$: 301 to 500 dollars; Cost is highly variable and subject to institutional contractual agreements.
Delayed resorption can occur with oxidized regenerated cellulose due to the low pH which inhibits proteases and elastases. May delay for more than 2 weeks.
Fibrinogen concentration are higher for commercial preparations (Tisseel 70 mg/mL and Evicel 55 to 85 mg/mL) as compared to unmanipulated cryoprecipitate (2.5 to 25 mg/mL) [10, 11].
3.1 Mechanical
When normal mechanical techniques for maintaining hemostasis such as pressure, sutures, clips, gauze sponges fail or cannot be used due to sensitive anatomic location, mechanical topical hemostatic agents can be used alone or in combination (not all mechanical products) with thrombin. Mechanical agents act as a scaffold for platelet aggregation and can dehydrate the injury bed allowing for a local increase in clotting factors. This type of hemostatic agent when used alone acts passively to control hemostasis which means that an intact clotting cascade is necessary for adequate clot stabilization. The properties of the most common topical mechanical hemostatic agents are listed below and included in Table 1. Clinically, these agents are useful with heavier bleeding (especially if combined with an active hemostatic agent like thrombin) because they can absorb multiple times their weight in fluid [12]. Given expansion of these agents, caution should be exercised when applying them in anatomic locations where there is risk for nerve injury. If these agents are needed near nerves, it is recommended that after hemostasis is achieved, residual agent is removed [13]. Although it is not possible to conduct randomized trials with topical hemostatic agents, one study evaluated many of these mechanical agents in vitro and found that microfibrillar collagen was the most effective followed by collagen sponge, gelatin sponge and oxidized regenerated cellulose [14].
Use of mechanical hemostatic agents can mimic abcess formation on postoperative imaging [15]. Interpretation as to whether its abscess versus normal degeneration of topical hemostatic agents may be aided by informing radiologist that topical hemostatic agents have been used [16]. An abscess typically has rim enhanced and air-fluid levels. Topical hemostatic agent degeneration usually has tightly packed gas bubbles which remain unchanged on serial exams with no rim enhancement or air-fluid levels [16]. Often, as mechanical hemostatic agents degenerate over time, they may be mistaken as granulomas or malignancy [17, 18].
This type of mechanical agent is used in cases of relatively light venous bleeding. Minimal preparation is required, and it is the least expensive of hemostatic agents utilized. ORC can be used in heparinized patients although efficacy in thrombocytopenic patients is limited [19].
When applied directly to tissue, oxidized regenerated cellulose creates a scaffold for platelet aggregation. By decreasing tissue pH, it works to further hemostasis by activating the clotting cascade. The decreased pH may have an additional benefit: bactericidal activity [5]. This agent, however, should not be used with biologic agents (Thrombin) [3].
Oxidized Regenerated Cellulose comes in different forms: Powder, cloth, foam, and sponge. These are absorbed in 14 days but can persist up to 1 year [14]. The cloth form of ORC is easily rolled and can be placed through a laparoscopic trocar. These agents may also help to prevent development of adhesions although evidence to support this is limited [20] It should be noted that ORC has been associated with abscess formation.
Gelatins (Gelfoam,Surgifoam)
Made from porcine collagen, gelatin hemostatic agents, comprised of powder or foam, can be saturated with normal saline to form a paste [9]. These agents provide a matrix for clot formation and can expand up to 200%. When applied directly to tissue, these agents can act as a sponge to absorb blood. Clotting occurs through contact activation as the gelatin particles restrict blood flow and provide a stable matrix for a clot to form [21]. Pressure is necessary for several minutes for optimal hemostasis. Pressure will also keep the gelatin from dislodging [19].
Gelatins are absorbed within 4–6 weeks. These agents can also be passed through laparoscopic trocars. Because these agents have a neutral pH they can be used with biologic agents [7]. Gelatins are frequently (and easily) combined with activated thrombin to augment hemostasis if there is brisk bleeding.
Microfibrillar collagen is applied directly to tissue and acts as a scaffolding for platelet aggregation [3]. These agents are available as a sheet, powder, or sponge. They can be difficult to handle, however, because they tend to stick to gloves and instruments [14]. These agents are absorbed in 2–3 months. Combining microfibrillar collagen with thrombin or saline may reduce the hemostatic efficacy of the microfibrillar collagen. It is important to note that granulomatous reactions with microfibrillar collagens have been linked to bowel obstruction and surgical re-exploration.
These agents are made from potato starch and are available in powder form for laparoscopic application [3]. By absorbing water, these agents work to concentrate platelets to accelerate clot formation. It can be applied to the surgical field with gentle pressure. These agents are absorbed within 48 hours limiting potential for lasting complications such as abscess formation or bowel obstruction [3]. These agents are not meant to be combined with activated thrombin as adding liquid will impair the ability of the starch to absorb water in the field. Laparoscopic applicators are available to spray the starch intraabdominally during laparoscopic surgery. As these agents are made from potato starch, they are inexpensive.
3.2 Biological
Bovine thrombin (Thrombin-jmi), Pooled human thrombin (Evithrom), Recombinant thrombin (Recothrom).
Biological hemostatic agents are active agents that work to provide hemostasis by activating clotting factors in the final stages of the coagulation cascade. Thrombin is activated by calcium and as noted previously acts to convert fibrinogen to fibrin, stabilizing the clot. Although activated thrombin does not require circulating clotting factors to work, it will not be effective if there is hypofibrinogenemia which is often seen in cases of disseminated intravascular coagulation (DIC). Bovine thrombin has been approved for use since the 1970s. Thrombin alone is indicated for localized, minor bleeding and is dispersed as a liquid spray. Thrombin can be reconstituted from a powder or thawed from frozen formulations to form a liquid or paste which can then be applied alone or in conjunction with absorbable gelatin [22, 23, 24]. In obstetrical and gynecological surgery, thrombin is rarely used alone. Fibrinogen was combined with concentrated plasma thrombin in the late 1990s creating a fibrin sealant [25]. Fibrin sealants can also contain a matrix to support platelet aggregation and activation. From a biologic perspective, fibrin sealants are more likely to provide hemostasis in case of coagulopathy/DIC because fibrinogen is supplied with thrombin. Combining active (thrombin or thrombin with fibrinogen) with a passive hemostatic agent can significantly improve hemostasis. In vitro and clinical studies have demonstrated faster hemostasis with the use of active hemostatic agents [26, 27]. Active hemostatic agents are uniformly more costly than mechanical (passive) hemostatic agents. The risks of using human or bovine products is low Flowable-Floseal, Gelfoam.
When thrombin is combined with gelatin granules, hemostasis can be achieved on wet, actively bleeding tissue. As gelatin capsules swell, this leads to mechanical tamponade (passive). Thrombin then converts patients’ fibrinogen to fibrin further stabilizing the clot. These agents require intraoperative preparation and are applied with paste like consistency [24]. Flowable agents may contribute to adhesive disease and may be associated with small bowel obstruction [28, 29]. They are typically absorbed in 6–8 weeks and can sometimes be mistaken for abscess on postoperative imaging. Products like floseal are available with a laparoscopic applicator to facilitate placement of the agent during complicated laparoscopic surgery.
3.3 Fibrin sealants
Pooled human plasma (Tisseel, Evicel), Pooled human and equine collagen (Tachosil), Individual human plasma with bovine collagen and thrombin (Vitagel).
Fibrin sealants provide high levels of fibrinogen and thrombin separately that when combined form a fibrin clot at an accelerated speed. Fibrin sealants are comprised of 2 parts: a sealer protein solution containing aprotinin, factor XII, and fibrinogen, and a second component containing thrombin. Concentration of fibrinogen determines strength of sealant, and thrombin determines speed of clot formation [14]. Fibrin sealants are very effective and are best used for bleeding from large surfaces such as diffuse peritoneal bleeding after removal of a mass/malignancy. In a randomized trial of 224 patients comparing fibrin sealant to ORC for bleeding after liver resection, 81% acquired hemostasis in 3 mins versus 50% with ORC [30]. Fibrin sealants have also been used off-label as an adhesion barrier, but this is controversial and expensive.
4. Practical usage of topical hemostatic agents in obstetrics and gynecology
Selection of a particular topical hemostatic agent in Ob/Gyn depends entirely on the clinical situation, local availability of agents, and cost considerations. There is no “one size fits all” agent. The ideal topical hemostatic agent will control hemostasis rapidly, have a low risk of adverse events, be easy to prepare and handle, and be compatible with any patient factors [12]. Examples of practical usage of topical hemostatic agents in Ob/Gyn are provided in the following sections.
4.1 Obstetrical usage
In obstetrics, topical hemostatic agents are most often used to control postpartum hemorrhage in the setting of postpartum hysterectomy. Hemorrhage at time of cesarean section is the leading cause of morbidity. Eight percent of maternal deaths are due to postpartum hemorrhage in the United States [31]. Common indications for postpartum hysterectomy include abnormal placentation and uterine atony. Abnormal placentation has replaced uterine atony as the most common indication leading to emergency postpartum hysterectomy [31]. Placenta accreta now occurs in as many as 1 in 553 pregnancies. Topical hemostatic agents may be applied if traditional techniques for controlling postpartum hemorrhage such as: uterotonic agents, vessel ligation, packing, balloon tamponade, over–sewing the placental bed, compression sutures, or uterine artery embolization are not successful. Topical hemstatic agents may be particularly helpful in cases of placenta previa with lower segment and implantation site bleeding. Bleeding can be brisk and present over large surfaces in these cases. Additionally, patients with hemorrhage can have factor and fibrinogen deficiencies. Therefore, fibrin sealants and agents that have both mechanical and biological properties are preferred. Hemorrhage at time of cesarean section is the leading cause of morbidity. 8% maternal deaths are due to postpartum hemorrhage in the United States [31]. With the statistics provided above, excellent hemostasis has become imperative for the safety and well being of obstetrical patients.
In 2007, Moriarty, et al. [32], presented a case reporting the use of topical hemostatic agents in massive postpartum hemorrhage. In this case the patient had a cesarean section for placental abruption. Due to persistent uterine atony and hemorrhage unresponsive to typical management techniques, she underwent a total abdominal hysterectomy. This was complicated by DIC with persistent bleeding from venous plexus at vaginal vault. FloSeal, a flowable hemostatic agent, was applied and hemostasis was achieved [32]. FloSeal was also used to control persistent postpartum hemorrhage from implantation site with success [33, 34]. In a case series, by Chung et al. in 2017, of 11 patients with obstetrical hemorrhage, 10 were controlled with intrauterine Floseal, with only 1 failure that required hysterectomy [35].
Fibrin sealants have also been used as an adjunct to control hemostasis at the placental implantation site. In 2010, Fuglsang and Petersen [36], published a series of 15 cases in which all cases were complicated by placenta previa and delivered by cesarean section. All were complicated by persistent bleeding from the lower uterine segment. Hemostasis was controlled with the topical application of Tachosil [36].
Although most applications of topical hemostatic agents occur at the time of cesarean section or hysterectomy, they have also been used to control hemostasis from vaginal and vulvar lacerations that occur following traumatic vaginal deliveries [37].
4.2 Gynecologic usage
Use of topical hemostatic agents is far more common in gynecologic surgery than in obstetrics. Common cases that may require use of topical hemostatic agents include hysterectomies, ovarian cystectomies myomectomy, endometriosis resection/ablation, incontinence procedures, and malignant debulking procedures. In these cases, advantages to use of topical hemostasis include fewer transfusions, improved visualization of the surgical field, and decreased operative time which can all potentially decrease morbidity and mortality [12].
There has been a trend over the past two decades towards application of minimally invasive surgical approaches [38]. At our institution, for example, more than 84% of hysterectomies are performed laparoscopically. If there is diffuse small vessel bleeding, bleeding near the ureter or adjacent to major vessels (such as in the parametrium), using a topical hemostatic agent may reduce the risk of conversion to laparotomy. A systematic review of topical hemostatic agents used in minimally invasive gynecologic surgery (MIGS) concluded that application of topical hemostatic agents in MIGS procedures can decrease operative time, blood loss, and may ameliorate damage to ovarian function. However, more data is needed on usage of hemostatic agents during other procedures like myomectomy, hysterectomy, and adnexal surgery [39]. In cases whereressure, electrosurgery, suturing, or stapling, may not be feasible during minimally invasive procedures such as with diffuse small vessel bleeding, bleeding near ureter or major vessels, usage of topical hemostatic agents may be another option before converting to laparotomy.
4.3 Hysterectomy
Hysterectomy is the most common major gynecological procedure. More than 430,000 hysterectomies are performed in the United States every year. Most are performed for benign reasons [39].
Usage of hemostatic agents during laparoscopic or robotic hysterectomies has increased since introduction of fibrin sealants in the 1990’s. Minimally invasive hysterectomy typically has less blood loss than open hysterectomy, so indications for topical hemostatic use may be less clear [4]. Evidence suggests that use of topical hemostatic agents at the time of hysterectomy is controversial. A study by Kakos, et al. [40], evaluated factors associated with the usage of hemostatic agents during traditional laparoscopic or robotic hysterectomies. Findings from this study revealed that the usage of hemostatic agents at the time of traditional laparoscopic or robotic hysterectomy was not associated with aggregate differences in intraoperative or postoperative bleeding metrics. Length of stay was also unchanged relative to similar hysterectomies performed without the routine use of hemostatic agents. Their findings supported the idea that surgeon’s usage of these products was for prophylaxis rather than treatment [40]. Similar findings were published by Obermair, et al. [41], who compared adverse events and surgical outcomes of hysterectomy with or without usage of gelatin –thrombin matrix (Surgiflo). Surgiflo neither prevented nor caused additional adverse events in women undergoing hysterectomies [41].
Watrowski,et al. [42], studied the impact of the use of intraoperative hemostatic gelatin –thrombin matrix (FloSeal, Baxter healthcare) on transfusion rates and short-term perioperative outcomes in gynecological surgery. They found that usage of these hemostatic agents was associated with significantly better short- term perioperative outcomes including, shortened surgical and hospital times, less postoperative anemia, fewer blood transfusions, and reduced number of reoperations and ICU stays [42].
Despite the dogma that improved hemostasis can lead to improved clinical outcomes, there is evidence demonstrating the potential harms of topical hemostatic agents if used inappropriately. Harris, et al. [43], performed a retrospective cohort study of hemostatic agents used during hysterectomy and risk of postoperative complications. Women who received a hemostatic agent (N = 4659) were compared to women who did not receive a topical hemostatic agent (N = 9316). Hemostatic agent usage was associated with an increased rate of hospital readmission. Among all hysterectomy approaches, hemostatic agents used during robotic- assisted laparoscopic hysterectomy associated with an increased predicted rate of blood transfusions, and increase predicted rate of pelvic abscess diagnosis, and increased predicted rate of hospital readmission, and increased predicted rate of re-operation Their conclusion was that hemostatic agents should be used carefully owing to associations with increased postoperative re-admissions and re-operations when used during hysterectomy [43]. This study, however, did not control for diagnosis, making malignancy a cofounder and limiting strong conclusions regarding risks of hemostatic agent use in hysterectomy for benign indications [22]. Harris et al., in a second large retrospective study, compared postoperative outcomes between cohorts of patients undergoing hysterectomy for benign indications that fulfilled a perioperative bundle of four criteria. These included a minimally invasive approach, appropriate preoperative antibiotics, operative duration of less than 2 hours, and absence of intraoperative hemostatic agent use. Of all cohorts missing only one of the four criteria, there was an association with a greater risk of post-operative complications in hyterectomies for benign indications in which hemostatic agents were used [44].
4.4 Myomectomy
Leiomyomas are the most common benign gynecologic tumor, with an estimated instance of 70–80% in women by the age 50 years [45, 46]. Most patients with leiomyomas are asymptomatic. For those with symptoms related to bulk, abnormal uterine bleeding, or infertility, there are typically multiple management options. These include: observation, medical management, uterine artery embolization, ablative procedures, and surgical resection. Surgical resection (in the absence of hysterectomy) is inclusive of hysteroscopic, laparoscopic, and open myomectomy. A variety of different medical techniques have been used to diminish blood loss during the myomectomy. These include vaginal prostaglandins, vasopressin, bupivacaine with epinephrine, oxytocin, fibrin sealant coated suture, IV tranexamic acid, and GnRH analogs. The evidence presented here will focus on topical hemostatic agents used during myomectomy.
A retrospective study by Barakat, et al. [47], found that 6.5% of patients undergoing an abdominal approach and 1.1% of patients undergoing a minimally invasive approach will require a blood transfusion. Approximately 2% would be converted to a laparotomy [47].
A variety of different medical techniques have been used to diminish blood loss during the myomectomy. These include vaginal prostaglandins, vasopressin, bupivacaine with epinephrine, oxytocin, fibrin –sealant coated suture, IV tranexamic acid, GnRH analogs. For the purpose of this chapter review, the focus will be on hemostatic agents during myomectomy.
Raga, et al., did a review of Floseal compared to placebo in a randomized cohort of 50 women undergoing myomectomy. Estimated blood loss (EBL) was significantly decreased in the treatment group. Length of stay and intraoperative blood transfusions were also less in the treatment group. Postoperative hemoglobin was significantly higher in the treatment group [48]. Fibrin sealants have also been studied in myomectomy. Tisseel has been shown to decrease mean time to achieve hemostasis, operative time, EBL, and post-operative HgB change [49].
4.5 Endometriosis resection
Endometriosis is a benign chronic disease associated with pain, dyspareunia, and infertility. Surgical options for conservative treatment include electrocauterization of cyst wall, cystectomy, and laser vaporization of cyst wall. Laparoscopic ovarian cystectomy has a significantly reduced rate of recurrence and an increased pregnancy rate when compared to coagulation and laser ablation methods [50, 51]. The goals of endometriosis resection in reproductive aged women are pain control and enhancement of fertility. Topical hemostatic agents have been investigated as an alternative to bipolar cautery and suturing to control hemostasis during ovarian cystectomy. The rationale is that there will be less trauma to the ovary and less impact on ovarian reserve [52, 53, 54]. A meta-analysis concluded that use of hemostatic agents was associated with significantly less decline in ovarian reserve over bipolar dissection [55]. Choi, et al. [56], investigated the impact of topical hemostatic agents and bipolar coagulation during laparoscopic ovarian endometriotic cyst resection on ovarian reserve by comparing the postoperative anti-mullerian hormone (AMH) levels. AMH was significantly decreased in both groups 3 months postoperatively. However, the rate of decrease in the bipolar coagulation group was greater than that of the hemostatic sealant group [56]. These findings were further supported by a multi -centered, randomized controlled trial that showed no difference in operative outcomes, operative time, estimated blood loss or perioperative complications between the bipolar and topical hemostatic agent groups. Similarly, in both groups, postoperative AMH levels were lower than pre-operative AMH levels, but the rate of decline of AMH levels was greater in the bipolar group than in the hemostatic sealant group [57, 58, 59].
When peritoneal endometriosis is resected or ablated, there can be diffuse bleeding from multiple sites. Peritoneal endometriosis is frequently found in the deep pelvis on the surface of the uterosacral ligaments and over the path of the ureter. Controlling bleeding during these often complicated peritoneal resections can be challenging with conventional methods and application of topical hemostatic agents may be helpful [60]. There is not strong evidence for or against use of topical hemostatic agents for this particular indication.
5. Risks of topical hemostatic agent use
Several case reports have discussed risks of hemostatic agent use in gynecologic surgery including abscess formation, mimickry of abscess or malignant disease, small-bowel obstruction, blood –borne disease transmission, thrombus formation, and allergic reactions [3, 17, 19, 22, 24, 61, 62, 63].
Abscesses, or mimickry of abscesses, on imaging, is the most commonly reported complications of topical hemostatic agents. Mechanical agents being the most frequently associated. Fagotti, et al., demonstrated a statistically significant association between oxidative regenerating cellulose (ORC) (Surgicel) and pelvic abscess formation (11.8% with ORC verses 1.7% without) [15].
Anderson, et al., in a retrospective cohort study examined all malignancy related hysterectomies, and hysterectomies for benign indications through all routes except vaginal. Gelatin-thrombin matrix (GTM) was used in 40% of cases. 3% developed abscess. Based on this, their recommendation was that liberal use of GTM should be used with caution in clean contaminated cases [15].
A large retrospective cohort study of over 17,000 patients, by Harris et al., examined the use of hemostatic agents during all routes of hysterectomy and evaluated risks of post-operative complications. Among all hysterectomy approaches, and after adjusting for demographic and surgical factors, hemostatic agent use during robotic assisted laparoscopic hysterectomy was associated with an increased predicted rate of blood transfusions, and increased predicted rate of pelvic abscess diagnosis, and increased predicted rate of hospital readmission, and an increased predicted rate of reoperation. Their conclusion was that hemostatic agent should be use carefully owing to associations with increased postoperative re-admissions and re-operations when use during hysterectomy [43].
Collections seen postoperatively on imaging may be misinterpreted as an abscess [15]. Interpretation as to whether its abscess versus normal degeneration of topical hemostatic agents may be aided by informing radiologist that topical hemostatic agents have been used [16]. An abscess typically has rim enhanced and air-fluid levels. Topical hemostatic agent degeneration usually has tightly packed gas bubbles which remain unchanged on serial exams with no rim enhancement or air-fluid levels [16]. Often, as mechanical hemostatic agents degenerate over time, they may be mistaken as granulomas or malignancy [17, 18].
The next most common complication associated with topical hemostatic agents is small-bowel obstruction secondary to inflammatory foreign body giant cell reaction. Symptoms may present on postoperative days 5–9 [29, 64]. To decrease the chances of this occurring, as per package insert, excess topical hemostatic agents should be gently irrigated and removed.
Another concern regarding usage of biological agents is the potential for immunological risks. Agents that contain bovine thrombin have been associated with antibody –mediated reactions that have resulted in bleeding diatheses [65].
Donor pool human derived thrombin, approved in 2007 by the FDA, may potentially carry risk of viral disease transmission including HIV, hepatitis, parvovirus B19.
Recombinant thrombin may eliminate the risk of disease transmission and decreased immunologic response. However, allergic reactions to animal proteins have been reported [23].
6. Conclusion
Topical hemostatic agents should be used as an adjunct to good surgical technique. There are many potential applications of topical hemostatic agents in obstetrics and gynecology. Choice of topical hemostatic agent is at the discretion of the clinician and subject to hospital availability and cost. Mechanical hemostatic agents are passive and augment endemic clotting factors. Biologic hemostatic agents are active because they contain thrombin allowing better clot stabilization. Combining mechanical and biologic hemostatic agents (often done at the product level) can improve efficacy at a higher price point. Although the goal of these agents is to improve postoperative outcomes, there is limited evidence to support their widespread use in obstetrics and gynecology. In-depth knowledge of the risks and benefits of these agents is important because appropriate use has the potential to improve clinical outcomes. Since hemostatic agents have been introduced, they have been applied across many subspecialties, including Obstetrics and Gynecology. Knowledge of their mechanisms of actions, potential complications from their use, and limited and often conflicting data behind case-specific applications, warrants judicious usage of these agents. Larger studies, specifically on case- specific usage, along with focus on value-based applications, need to be done before empiric recommendations on routine usage of these agents can be made. At this point they should only be used as an adjunct to traditional means of achieving hemostasis.
Department of Obstetrics and Gynecology, St. Luke’s University Health Network, Bethlehem, Pennsylvania, USA
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The company was founded in Vienna in 2004 by Alex Lazinica and Vedran Kordic, two PhD students researching robotics. While completing our PhDs, we found it difficult to access the research we needed. So, we decided to create a new Open Access publisher. A better one, where researchers like us could find the information they needed easily. The result is IntechOpen, an Open Access publisher that puts the academic needs of the researchers before the business interests of publishers.
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We started by publishing journals and books from the fields of science we were most familiar with - AI, robotics, manufacturing and operations research. Through our growing network of institutions and authors, we soon expanded into related fields like environmental engineering, nanotechnology, computer science, renewable energy and electrical engineering, Today, we are the world’s largest Open Access publisher of scientific research, with over 4,200 books and 54,000 scientific works including peer-reviewed content from more than 116,000 scientists spanning 161 countries. Our authors range from globally-renowned Nobel Prize winners to up-and-coming researchers at the cutting edge of scientific discovery.
\\n\\n
In the same year that IntechOpen was founded, we launched what was at the time the first ever Open Access, peer-reviewed journal in its field: the International Journal of Advanced Robotic Systems (IJARS).
\\n\\n
The IntechOpen timeline
\\n\\n
2004
\\n\\n
\\n\\t
Intech Open is founded in Vienna, Austria, by Alex Lazinica and Vedran Kordic, two PhD students, and their first Open Access journals and books are published.
\\n\\t
Alex and Vedran launch the first Open Access, peer-reviewed robotics journal and IntechOpen’s flagship publication, the International Journal of Advanced Robotic Systems (IJARS).
\\n
\\n\\n
2005
\\n\\n
\\n\\t
IntechOpen publishes its first Open Access book: Cutting Edge Robotics.
\\n
\\n\\n
2006
\\n\\n
\\n\\t
IntechOpen publishes a special issue of IJARS, featuring contributions from NASA scientists regarding the Mars Exploration Rover missions.
\\n
\\n\\n
2008
\\n\\n
\\n\\t
Downloads milestone: 200,000 downloads reached
\\n
\\n\\n
2009
\\n\\n
\\n\\t
Publishing milestone: the first 100 Open Access STM books are published
\\n
\\n\\n
2010
\\n\\n
\\n\\t
Downloads milestone: one million downloads reached
\\n\\t
IntechOpen expands its book publishing into a new field: medicine.
\\n
\\n\\n
2011
\\n\\n
\\n\\t
Publishing milestone: More than five million downloads reached
\\n\\t
IntechOpen publishes 1996 Nobel Prize in Chemistry winner Harold W. Kroto’s “Strategies to Successfully Cross-Link Carbon Nanotubes”. Find it here.
\\n\\t
IntechOpen and TBI collaborate on a project to explore the changing needs of researchers and the evolving ways that they discover, publish and exchange information. The result is the survey “Author Attitudes Towards Open Access Publishing: A Market Research Program”.
\\n\\t
IntechOpen hosts SHOW - Share Open Access Worldwide; a series of lectures, debates, round-tables and events to bring people together in discussion of open source principles, intellectual property, content licensing innovations, remixed and shared culture and free knowledge.
\\n
\\n\\n
2012
\\n\\n
\\n\\t
Publishing milestone: 10 million downloads reached
\\n\\t
IntechOpen holds Interact2012, a free series of workshops held by figureheads of the scientific community including Professor Hiroshi Ishiguro, director of the Intelligent Robotics Laboratory, who took the audience through some of the most impressive human-robot interactions observed in his lab.
\\n
\\n\\n
2013
\\n\\n
\\n\\t
IntechOpen joins the Committee on Publication Ethics (COPE) as part of a commitment to guaranteeing the highest standards of publishing.
\\n
\\n\\n
2014
\\n\\n
\\n\\t
IntechOpen turns 10, with more than 30 million downloads to date.
\\n\\t
IntechOpen appoints its first Regional Representatives - members of the team situated around the world dedicated to increasing the visibility of our authors’ published work within their local scientific communities.
\\n
\\n\\n
2015
\\n\\n
\\n\\t
Downloads milestone: More than 70 million downloads reached, more than doubling since the previous year.
\\n\\t
Publishing milestone: IntechOpen publishes its 2,500th book and 40,000th Open Access chapter, reaching 20,000 citations in Thomson Reuters ISI Web of Science.
\\n\\t
40 IntechOpen authors are included in the top one per cent of the world’s most-cited researchers.
\\n\\t
Thomson Reuters’ ISI Web of Science Book Citation Index begins indexing IntechOpen’s books in its database.
\\n
\\n\\n
2016
\\n\\n
\\n\\t
IntechOpen is identified as a world leader in Simba Information’s Open Access Book Publishing 2016-2020 report and forecast. IntechOpen came in as the world’s largest Open Access book publisher by title count.
\\n
\\n\\n
2017
\\n\\n
\\n\\t
Downloads milestone: IntechOpen reaches more than 100 million downloads
\\n\\t
Publishing milestone: IntechOpen publishes its 3,000th Open Access book, making it the largest Open Access book collection in the world
We started by publishing journals and books from the fields of science we were most familiar with - AI, robotics, manufacturing and operations research. Through our growing network of institutions and authors, we soon expanded into related fields like environmental engineering, nanotechnology, computer science, renewable energy and electrical engineering, Today, we are the world’s largest Open Access publisher of scientific research, with over 4,200 books and 54,000 scientific works including peer-reviewed content from more than 116,000 scientists spanning 161 countries. Our authors range from globally-renowned Nobel Prize winners to up-and-coming researchers at the cutting edge of scientific discovery.
\n\n
In the same year that IntechOpen was founded, we launched what was at the time the first ever Open Access, peer-reviewed journal in its field: the International Journal of Advanced Robotic Systems (IJARS).
\n\n
The IntechOpen timeline
\n\n
2004
\n\n
\n\t
Intech Open is founded in Vienna, Austria, by Alex Lazinica and Vedran Kordic, two PhD students, and their first Open Access journals and books are published.
\n\t
Alex and Vedran launch the first Open Access, peer-reviewed robotics journal and IntechOpen’s flagship publication, the International Journal of Advanced Robotic Systems (IJARS).
\n
\n\n
2005
\n\n
\n\t
IntechOpen publishes its first Open Access book: Cutting Edge Robotics.
\n
\n\n
2006
\n\n
\n\t
IntechOpen publishes a special issue of IJARS, featuring contributions from NASA scientists regarding the Mars Exploration Rover missions.
\n
\n\n
2008
\n\n
\n\t
Downloads milestone: 200,000 downloads reached
\n
\n\n
2009
\n\n
\n\t
Publishing milestone: the first 100 Open Access STM books are published
\n
\n\n
2010
\n\n
\n\t
Downloads milestone: one million downloads reached
\n\t
IntechOpen expands its book publishing into a new field: medicine.
\n
\n\n
2011
\n\n
\n\t
Publishing milestone: More than five million downloads reached
\n\t
IntechOpen publishes 1996 Nobel Prize in Chemistry winner Harold W. Kroto’s “Strategies to Successfully Cross-Link Carbon Nanotubes”. Find it here.
\n\t
IntechOpen and TBI collaborate on a project to explore the changing needs of researchers and the evolving ways that they discover, publish and exchange information. The result is the survey “Author Attitudes Towards Open Access Publishing: A Market Research Program”.
\n\t
IntechOpen hosts SHOW - Share Open Access Worldwide; a series of lectures, debates, round-tables and events to bring people together in discussion of open source principles, intellectual property, content licensing innovations, remixed and shared culture and free knowledge.
\n
\n\n
2012
\n\n
\n\t
Publishing milestone: 10 million downloads reached
\n\t
IntechOpen holds Interact2012, a free series of workshops held by figureheads of the scientific community including Professor Hiroshi Ishiguro, director of the Intelligent Robotics Laboratory, who took the audience through some of the most impressive human-robot interactions observed in his lab.
\n
\n\n
2013
\n\n
\n\t
IntechOpen joins the Committee on Publication Ethics (COPE) as part of a commitment to guaranteeing the highest standards of publishing.
\n
\n\n
2014
\n\n
\n\t
IntechOpen turns 10, with more than 30 million downloads to date.
\n\t
IntechOpen appoints its first Regional Representatives - members of the team situated around the world dedicated to increasing the visibility of our authors’ published work within their local scientific communities.
\n
\n\n
2015
\n\n
\n\t
Downloads milestone: More than 70 million downloads reached, more than doubling since the previous year.
\n\t
Publishing milestone: IntechOpen publishes its 2,500th book and 40,000th Open Access chapter, reaching 20,000 citations in Thomson Reuters ISI Web of Science.
\n\t
40 IntechOpen authors are included in the top one per cent of the world’s most-cited researchers.
\n\t
Thomson Reuters’ ISI Web of Science Book Citation Index begins indexing IntechOpen’s books in its database.
\n
\n\n
2016
\n\n
\n\t
IntechOpen is identified as a world leader in Simba Information’s Open Access Book Publishing 2016-2020 report and forecast. IntechOpen came in as the world’s largest Open Access book publisher by title count.
\n
\n\n
2017
\n\n
\n\t
Downloads milestone: IntechOpen reaches more than 100 million downloads
\n\t
Publishing milestone: IntechOpen publishes its 3,000th Open Access book, making it the largest Open Access book collection in the world
\n
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It performs very complex tasks while occupying about 2 liters of volume and consuming very little energy. The computation tasks are performed by special cells in the brain called neurons. They compute using electrical pulses and exchange information between them through chemicals called neurotransmitters. With this as inspiration, there are several compute models which exist today trying to exploit the inherent efficiencies demonstrated by nature. The compute models representing spiking neural networks (SNNs) are biologically plausible, hence are used to study and understand the workings of brain and nervous system. More importantly, they are used to solve a wide variety of problems in the field of artificial intelligence (AI). They are uniquely suited to model temporal and spatio-temporal data paradigms. This chapter explores the fundamental concepts of SNNs, few of the popular neuron models, how the information is represented, learning methodologies, and state of the art platforms for implementing and evaluating SNNs along with a discussion on their applications and broader role in the field of AI and data networks.",book:{id:"10372",slug:"biomimetics",title:"Biomimetics",fullTitle:"Biomimetics"},signatures:"Khadeer Ahmed",authors:[{id:"320026",title:"Dr.",name:"Khadeer",middleName:null,surname:"Ahmed",slug:"khadeer-ahmed",fullName:"Khadeer Ahmed"}]},{id:"65418",title:"Opening the “Black Box” of Silicon Chip Design in Neuromorphic Computing",slug:"opening-the-black-box-of-silicon-chip-design-in-neuromorphic-computing",totalDownloads:1565,totalCrossrefCites:3,totalDimensionsCites:3,abstract:"Neuromorphic computing, a bio-inspired computing architecture that transfers neuroscience to silicon chip, has potential to achieve the same level of computation and energy efficiency as mammalian brains. Meanwhile, three-dimensional (3D) integrated circuit (IC) design with non-volatile memory crossbar array uniquely unveils its intrinsic vector-matrix computation with parallel computing capability in neuromorphic computing designs. In this chapter, the state-of-the-art research trend on electronic circuit designs of neuromorphic computing will be introduced. Furthermore, a practical bio-inspired spiking neural network with delay-feedback topology will be discussed. In the endeavor to imitate how human beings process information, our fabricated spiking neural network chip has capability to process analog signal directly, resulting in high energy efficiency with small hardware implementation cost. Mimicking the neurological structure of mammalian brains, the potential of 3D-IC implementation technique with memristive synapses is investigated. Finally, applications on the chaotic time series prediction and the video frame recognition will be demonstrated.",book:{id:"6875",slug:"bio-inspired-technology",title:"Bio-Inspired Technology",fullTitle:"Bio-Inspired Technology"},signatures:"Kangjun Bai and Yang Yi",authors:[{id:"239041",title:"Prof.",name:"Yang",middleName:null,surname:"Yi",slug:"yang-yi",fullName:"Yang Yi"},{id:"245542",title:"Mr.",name:"Kangjun",middleName:null,surname:"Bai",slug:"kangjun-bai",fullName:"Kangjun Bai"}]},{id:"58622",title:"Bio-inspired Adaptable Facade Control Reflecting User's Behavior",slug:"bio-inspired-adaptable-facade-control-reflecting-user-s-behavior",totalDownloads:1587,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"The purpose of this research is to develop the process of methodology in designing adaptable façade. This study focuses on the processes of façade operation control for each resident’s unit according to the user’s lifestyle. This study aims to develop the design methods that are applicable to the adaptable facade, which is inspired by the design inspiration of the biomimicry. The ideal façade to increase comfort in internal space is an adaptable façade that can constantly respond to changes in the environments. This chapter attempts in active adoption of adaptable facade that makes it possible to respond to changing requirements and environments, eventually enabling the creation of customized services for users. This chapter explores the processes of designing an adaptable façade controlled by three rules inspired by the behaviors of flocks of birds. This chapter shows how adopted bird intelligence can produce various façade controls. Also, this chapter demonstrates biomimetic façade control that has been implemented by behavior-based design. Through this demonstration, this chapter identifies the potentials of biomimetic design in facade using rules of bird flocking as source of design inspiration. This study concludes that a behavior-based approach provides flexibly responding façade to environments increasing users’ quality of life.",book:{id:"5902",slug:"interdisciplinary-expansions-in-engineering-and-design-with-the-power-of-biomimicry",title:"Interdisciplinary Expansions in Engineering and Design With the Power of Biomimicry",fullTitle:"Interdisciplinary Expansions in Engineering and Design With the Power of Biomimicry"},signatures:"Hyunsoo Lee and Nayeon Kim",authors:[{id:"220502",title:"Prof.",name:"Hyunsoo",middleName:null,surname:"Lee",slug:"hyunsoo-lee",fullName:"Hyunsoo Lee"},{id:"220507",title:"Ms.",name:"Nayeon",middleName:null,surname:"Kim",slug:"nayeon-kim",fullName:"Nayeon Kim"}]}],onlineFirstChaptersFilter:{topicId:"690",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:288,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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These advances have helped foster better support for animal health, more humane animal production, and a better understanding of the physiology of endangered species to improve the assisted reproductive technologies or the pathogenesis of certain diseases, where animals can be used as models for human diseases (like cancer, degenerative diseases or fertility), and even as a guarantee of public health. Bridging Human, Animal, and Environmental health, the holistic and integrative “One Health” concept intimately associates the developments within those fields, projecting its advancements into practice. This book series aims to tackle various animal-related medicine and sciences fields, providing thematic volumes consisting of high-quality significant research directed to researchers and postgraduates. It aims to give us a glimpse into the new accomplishments in the Veterinary Medicine and Science field. 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After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. 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From\r\n1964 to 1974, he worked as Assistant in Biochemistry at the School of MedicineUniversidad Nacional de La Plata, Argentina. From 1974 to 1976, he was a Fellowof the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor oBiochemistry at the Universidad Nacional de La Plata, Argentina. He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. Angel Catalá received awards at the 40th InternationaConference Biochemistry of Lipids 1999: Dijon (France). W inner of the Bimbo PanAmerican Nutrition, Food Science and Technology Award 2006 and 2012, South AmericaHuman Nutrition, Professional Category. 2006 award in pharmacology, Bernardo\r\nHoussay, in recognition of his meritorious works of research. Angel Catalá belongto the Editorial Board of Journal of lipids, International Review of Biophysical ChemistryFrontiers in Membrane Physiology and Biophysics, World Journal oExperimental Medicine and Biochemistry Research International, W orld Journal oBiological Chemistry, Oxidative Medicine and Cellular Longevity, Diabetes and thePancreas, International Journal of Chronic Diseases & Therapy, International Journal oNutrition, Co-Editor of The Open Biology Journal.",institutionString:null,institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}},editorTwo:null,editorThree:null},{id:"12",title:"Human Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",isOpenForSubmission:!0,editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded his sports science diploma in 1995 by the University of Tsukuba and began his scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:null,editorThree:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. Her main research interest is sarcopenia in older adults, especially its association with nutritional status. Additionally, to understand how to maintain and improve physical function in older adults, to conduct studies about the mechanism of sarcopenia and determine when possible interventions are needed.",institutionString:null,institution:{name:"Ritsumeikan University",institutionURL:null,country:{name:"Japan"}}}},{id:"13",title:"Plant Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/13.jpg",isOpenForSubmission:!0,editor:{id:"332229",title:"Prof.",name:"Jen-Tsung",middleName:null,surname:"Chen",slug:"jen-tsung-chen",fullName:"Jen-Tsung Chen",profilePictureURL:"https://mts.intechopen.com/storage/users/332229/images/system/332229.png",biography:"Dr. Jen-Tsung Chen is currently a professor at the National University of Kaohsiung, Taiwan. He teaches cell biology, genomics, proteomics, medicinal plant biotechnology, and plant tissue culture. Dr. Chen\\'s research interests include bioactive compounds, chromatography techniques, in vitro culture, medicinal plants, phytochemicals, and plant biotechnology. He has published more than ninety scientific papers and serves as an editorial board member for Plant Methods, Biomolecules, and International Journal of Molecular Sciences.",institutionString:"National University of Kaohsiung",institution:{name:"National University of Kaohsiung",institutionURL:null,country:{name:"Taiwan"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:43,paginationItems:[{id:"81796",title:"Apoptosis-Related Diseases and Peroxisomes",doi:"10.5772/intechopen.105052",signatures:"Meimei Wang, Yakun Liu, Ni Chen, Juan Wang and Ye Zhao",slug:"apoptosis-related-diseases-and-peroxisomes",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81723",title:"Peroxisomal Modulation as Therapeutic Alternative for Tackling Multiple Cancers",doi:"10.5772/intechopen.104873",signatures:"Shazia Usmani, Shadma Wahab, Abdul Hafeez, Shabana Khatoon and Syed Misbahul Hasan",slug:"peroxisomal-modulation-as-therapeutic-alternative-for-tackling-multiple-cancers",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81638",title:"Aging and Neuropsychiatric Disease: A General Overview of Prevalence and Trends",doi:"10.5772/intechopen.103102",signatures:"Jelena Milić",slug:"aging-and-neuropsychiatric-disease-a-general-overview-of-prevalence-and-trends",totalDownloads:14,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81566",title:"New and Emerging Technologies for Integrative Ambulatory Autonomic Assessment and Intervention as a Catalyst in the Synergy of Remote Geocoded Biosensing, Algorithmic Networked Cloud Computing, Deep Learning, and Regenerative/Biomic Medicine: Further Real",doi:"10.5772/intechopen.104092",signatures:"Robert L. 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Buchholz",profilePictureURL:"https://mts.intechopen.com/storage/users/89438/images/6463_n.jpg",biography:"Full Professor and Vice Chair, Division of Pharmacology, Loma Linda University, School of Medicine. He received his B.S. Degree in Biology at La Sierra University, Riverside California (1980) and a PhD in Pharmacology from Loma Linda University School of Medicine (1988). Post-Doctoral Fellow at University of California, Irvine, College of Medicine 1989-1992 with a focus on autonomic nerve function in blood vessels and the impact of aging on the function of these nerves and overall blood vessel function. Twenty years of research funding and served on NIH R01 review panels, Editor-In-Chief of Edorium Journal of Aging Research. Serves as a peer reviewer for biomedical journals. Military Reserve Officer serving with the 100 Support Command, 100 Troop Command, 40 Infantry Division, CA National Guard.",institutionString:null,institution:{name:"Loma Linda University",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"6925",title:"Endoplasmic Reticulum",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6925.jpg",slug:"endoplasmic-reticulum",publishedDate:"April 17th 2019",editedByType:"Edited by",bookSignature:"Angel Català",hash:"a9e90d2dbdbc46128dfe7dac9f87c6b4",volumeInSeries:2,fullTitle:"Endoplasmic Reticulum",editors:[{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}}]},{type:"book",id:"6924",title:"Adenosine Triphosphate in Health and Disease",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6924.jpg",slug:"adenosine-triphosphate-in-health-and-disease",publishedDate:"April 24th 2019",editedByType:"Edited by",bookSignature:"Gyula Mozsik",hash:"04106c232a3c68fec07ba7cf00d2522d",volumeInSeries:3,fullTitle:"Adenosine Triphosphate in Health and Disease",editors:[{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. 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He\nreceived a short-term scholarship to carry out his post-doctoral\nstudies abroad, from Japan International Cooperation Agency\n(JICA), in coordination with the Egyptian government. Dr.\nShalaby speaks fluent English and his native Arabic. He has 77\ninternationally published research papers, has attended 15 international conferences, and has contributed to 18 international books and chapters.\nDr. Shalaby works as a reviewer on over one hundred international journals and is\non the editorial board of more than twenty-five international journals. He is a member of seven international specialized scientific societies, besides his local one, and\nhe has won seven prizes.",institutionString:"Cairo University",institution:{name:"Cairo University",institutionURL:null,country:{name:"Egypt"}}}]}]},openForSubmissionBooks:{},onlineFirstChapters:{},subseriesFiltersForOFChapters:[],publishedBooks:{paginationCount:10,paginationItems:[{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",slug:"animal-feed-science-and-nutrition-production-health-and-environment",publishedDate:"May 18th 2022",editedByType:"Edited by",bookSignature:"Amlan Kumar Patra",hash:"79944fc8fbbaa329aed6fde388154832",volumeInSeries:10,fullTitle:"Animal Feed Science and Nutrition - Production, Health and Environment",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan 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conducts his research at the Hamidiye Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Biochemistry, University of Health Sciences, Turkey. He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNVJQA4/Profile_Picture_2022-03-07T13:23:04.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Associate Prof.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. degree from Integral University. Currently, he’s working as an Assistant Professor of Pharmaceutics in the Faculty of Pharmacy, Integral University. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than 32 original articles published in reputed journals, 3 edited books, 5 book chapters, and a number of scientific articles published in ‘Ingredients South Asia Magazine’ and ‘QualPharma Magazine’. He is a member of the American Association for Cancer Research, International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}},{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",biography:"Dr. Margarete Dulce Bagatini is an associate professor at the Federal University of Fronteira Sul/Brazil. She has a degree in Pharmacy and a PhD in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee\nand a member of the Biovitta Research Institute. She is currently:\nthe leader of the research group: Biological and Clinical Studies\nin Human Pathologies, professor of postgraduate program in\nBiochemistry at UFSC and postgraduate program in Science and Food Technology at\nUFFS. She has experience in the area of pharmacy and clinical analysis, acting mainly\non the following topics: oxidative stress, the purinergic system and human pathologies, being a reviewer of several international journals and books.",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",country:{name:"Brazil"}}},{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226275/images/system/226275.jfif",biography:"Metin Budak, MSc, PhD is an Assistant Professor at Trakya University, Faculty of Medicine. He has been Head of the Molecular Research Lab at Prof. Mirko Tos Ear and Hearing Research Center since 2018. His specializations are biophysics, epigenetics, genetics, and methylation mechanisms. He has published around 25 peer-reviewed papers, 2 book chapters, and 28 abstracts. He is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of Medicine Faculty. His research area is the role of methylation during gene transcription, chromatin packages DNA within the cell and DNA repair, replication, recombination, and gene transcription. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.",institutionString:"Trakya University",institution:{name:"Trakya University",country:{name:"Turkey"}}},{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",biography:"Anca Pantea Stoian is a specialist in diabetes, nutrition, and metabolic diseases as well as health food hygiene. She also has competency in general ultrasonography.\n\nShe is an associate professor in the Diabetes, Nutrition and Metabolic Diseases Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. She has been chief of the Hygiene Department, Faculty of Dentistry, at the same university since 2019. Her interests include micro and macrovascular complications in diabetes and new therapies. Her research activities focus on nutritional intervention in chronic pathology, as well as cardio-renal-metabolic risk assessment, and diabetes in cancer. She is currently engaged in developing new therapies and technological tools for screening, prevention, and patient education in diabetes. \n\nShe is a member of the European Association for the Study of Diabetes, Cardiometabolic Academy, CEDA, Romanian Society of Diabetes, Nutrition and Metabolic Diseases, Romanian Diabetes Federation, and Association for Renal Metabolic and Nutrition studies. She has authored or co-authored 160 papers in national and international peer-reviewed journals.",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",country:{name:"Romania"}}},{id:"279792",title:"Dr.",name:"João",middleName:null,surname:"Cotas",slug:"joao-cotas",fullName:"João Cotas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279792/images/system/279792.jpg",biography:"Graduate and master in Biology from the University of Coimbra.\n\nI am a research fellow at the Macroalgae Laboratory Unit, in the MARE-UC – Marine and Environmental Sciences Centre of the University of Coimbra. My principal function is the collection, extraction and purification of macroalgae compounds, chemical and bioactive characterization of the compounds and algae extracts and development of new methodologies in marine biotechnology area. \nI am associated in two projects: one consists on discovery of natural compounds for oncobiology. The other project is the about the natural compounds/products for agricultural area.\n\nPublications:\nCotas, J.; Figueirinha, A.; Pereira, L.; Batista, T. 2018. An analysis of the effects of salinity on Fucus ceranoides (Ochrophyta, Phaeophyceae), in the Mondego River (Portugal). Journal of Oceanology and Limnology. in press. DOI: 10.1007/s00343-019-8111-3",institutionString:"Faculty of Sciences and Technology of University of Coimbra",institution:null},{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279788/images/system/279788.jpg",biography:"Leonel Pereira has an undergraduate degree in Biology, a Ph.D. in Biology (specialty in Cell Biology), and a Habilitation degree in Biosciences (specialization in Biotechnology) from the Faculty of Science and Technology, University of Coimbra, Portugal, where he is currently a professor. In addition to teaching at this university, he is an integrated researcher at the Marine and Environmental Sciences Center (MARE), Portugal. His interests include marine biodiversity (algae), marine biotechnology (algae bioactive compounds), and marine ecology (environmental assessment). Since 2008, he has been the author and editor of the electronic publication MACOI – Portuguese Seaweeds Website (www.seaweeds.uc.pt). He is also a member of the editorial boards of several scientific journals. Dr. Pereira has edited or authored more than 20 books, 100 journal articles, and 45 book chapters. He has given more than 100 lectures and oral communications at various national and international scientific events. He is the coordinator of several national and international research projects. In 1998, he received the Francisco de Holanda Award (Honorable Mention) and, more recently, the Mar Rei D. Carlos award (18th edition). He is also a winner of the 2016 CHOICE Award for an outstanding academic title for his book Edible Seaweeds of the World. In 2020, Dr. Pereira received an Honorable Mention for the Impact of International Publications from the Web of Science",institutionString:"University of Coimbra",institution:{name:"University of Coimbra",country:{name:"Portugal"}}},{id:"61946",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",slug:"carol-bernstein",fullName:"Carol Bernstein",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61946/images/system/61946.jpg",biography:"Carol Bernstein received her PhD in Genetics from the University of California (Davis). She was a faculty member at the University of Arizona College of Medicine for 43 years, retiring in 2011. Her research interests focus on DNA damage and its underlying role in sex, aging and in the early steps of initiation and progression to cancer. In her research, she had used organisms including bacteriophage T4, Neurospora crassa, Schizosaccharomyces pombe and mice, as well as human cells and tissues. She authored or co-authored more than 140 scientific publications, including articles in major peer reviewed journals, book chapters, invited reviews and one book.",institutionString:"University of Arizona",institution:{name:"University of Arizona",country:{name:"United States of America"}}},{id:"182258",title:"Dr.",name:"Ademar",middleName:"Pereira",surname:"Serra",slug:"ademar-serra",fullName:"Ademar Serra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/182258/images/system/182258.jpeg",biography:"Dr. Serra studied Agronomy on Universidade Federal de Mato Grosso do Sul (UFMS) (2005). He received master degree in Agronomy, Crop Science (Soil fertility and plant nutrition) (2007) by Universidade Federal da Grande Dourados (UFGD), and PhD in agronomy (Soil fertility and plant nutrition) (2011) from Universidade Federal da Grande Dourados / Escola Superior de Agricultura Luiz de Queiroz (UFGD/ESALQ-USP). Dr. Serra is currently working at Brazilian Agricultural Research Corporation (EMBRAPA). His research focus is on mineral nutrition of plants, crop science and soil science. Dr. Serra\\'s current projects are soil organic matter, soil phosphorus fractions, compositional nutrient diagnosis (CND) and isometric log ratio (ilr) transformation in compositional data analysis.",institutionString:"Brazilian Agricultural Research Corporation",institution:{name:"Brazilian Agricultural Research Corporation",country:{name:"Brazil"}}}]}},subseries:{item:{id:"91",type:"subseries",title:"Sustainable Economy and Fair Society",keywords:"Sustainable, Society, Economy, Digitalization, KPIs, Decision Making, Business, Digital Footprint",scope:"
\r\n\tGlobally, the ecological footprint is growing at a faster rate than GDP. This phenomenon has been studied by scientists for many years. However, clear strategies and actions are needed now more than ever. Every day, humanity, from individuals to businesses (public and private) and governments, are called to change their mindset in order to pursue a virtuous combination for sustainable development. Reasoning in a sustainable way entails, first and foremost, managing the available resources efficiently and strategically, whether they are natural, financial, human or relational. In this way, value is generated by contributing to the growth, improvement and socio-economic development of the communities and of all the players that make up its value chain. In the coming decades, we will need to be able to transition from a society in which economic well-being and health are measured by the growth of production and material consumption, to a society in which we live better while consuming less. In this context, digitization has the potential to disrupt processes, with significant implications for the environment and sustainable development. There are numerous challenges associated with sustainability and digitization, the need to consider new business models capable of extracting value, data ownership and sharing and integration, as well as collaboration across the entire supply chain of a product. In order to generate value, effectively developing a complex system based on sustainability principles is a challenge that requires a deep commitment to both technological factors, such as data and platforms, and human dimensions, such as trust and collaboration. Regular study, research and implementation must be part of the road to sustainable solutions. Consequently, this topic will analyze growth models and techniques aimed at achieving intergenerational equity in terms of economic, social and environmental well-being. It will also cover various subjects, including risk assessment in the context of sustainable economy and a just society.
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She has over 160 Scientific Publications in International Journals and Conferences and she is the author of 5 books on Innovation and Decision Making in Industrial Applications and Engineering.",institutionString:null,institution:{name:"Parthenope University of Naples",institutionURL:null,country:{name:"Italy"}}},editorTwo:null,editorThree:null,series:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:null},editorialBoard:[{id:"179628",title:"Prof.",name:"Dima",middleName:null,surname:"Jamali",slug:"dima-jamali",fullName:"Dima Jamali",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSAIlQAO/Profile_Picture_2022-03-07T08:52:23.jpg",institutionString:null,institution:{name:"University of Sharjah",institutionURL:null,country:{name:"United Arab Emirates"}}},{id:"170206",title:"Prof.",name:"Dr. Orhan",middleName:null,surname:"Özçatalbaş",slug:"dr.-orhan-ozcatalbas",fullName:"Dr. Orhan Özçatalbaş",profilePictureURL:"https://mts.intechopen.com/storage/users/170206/images/system/170206.png",institutionString:null,institution:{name:"Akdeniz University",institutionURL:null,country:{name:"Turkey"}}},{id:"250347",title:"Associate Prof.",name:"Isaac",middleName:null,surname:"Oluwatayo",slug:"isaac-oluwatayo",fullName:"Isaac Oluwatayo",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRVIVQA4/Profile_Picture_2022-03-17T13:25:32.jpg",institutionString:null,institution:{name:"University of Venda",institutionURL:null,country:{name:"South Africa"}}},{id:"141386",title:"Prof.",name:"Jesús",middleName:null,surname:"López-Rodríguez",slug:"jesus-lopez-rodriguez",fullName:"Jesús López-Rodríguez",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRBNIQA4/Profile_Picture_2022-03-21T08:24:16.jpg",institutionString:null,institution:{name:"University of A Coruña",institutionURL:null,country:{name:"Spain"}}},{id:"208657",title:"Dr.",name:"Mara",middleName:null,surname:"Del Baldo",slug:"mara-del-baldo",fullName:"Mara Del Baldo",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRLMUQA4/Profile_Picture_2022-05-18T08:19:24.png",institutionString:"University of Urbino Carlo Bo",institution:null}]},onlineFirstChapters:{},publishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"10795",title:"Plant Stress Physiology",subtitle:"Perspectives in Agriculture",coverURL:"https://cdn.intechopen.com/books/images_new/10795.jpg",slug:"plant-stress-physiology-perspectives-in-agriculture",publishedDate:"April 28th 2022",editedByType:"Edited by",bookSignature:"Mirza Hasanuzzaman and Kamran Nahar",hash:"c5a7932b74fe612b256bf95d0709756e",volumeInSeries:11,fullTitle:"Plant Stress Physiology - 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