Effect of hydrogel on photosynthetic activity and other physiological variables on buffel grass (
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More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"10411",leadTitle:null,fullTitle:"Materials at the Nanoscale",title:"Materials at the Nanoscale",subtitle:null,reviewType:"peer-reviewed",abstract:"Nanocrystals play very important roles in the interdisciplinary fields of biology, physics and chemistry. They are used for various applications, including to develop and formulate new drugs and vaccines to fight diseases and pandemics. This book contains nine chapters that discuss nanocrystals in electronics, medicine, the food industry, geology, and more.",isbn:"978-1-83968-823-2",printIsbn:"978-1-83968-822-5",pdfIsbn:"978-1-83968-824-9",doi:"10.5772/intechopen.91597",price:119,priceEur:129,priceUsd:155,slug:"materials-at-the-nanoscale",numberOfPages:184,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"be29908600b7067c583ac21da1544a2d",bookSignature:"Awadesh Kumar Mallik",publishedDate:"October 6th 2021",coverURL:"https://cdn.intechopen.com/books/images_new/10411.jpg",numberOfDownloads:2603,numberOfWosCitations:0,numberOfCrossrefCitations:2,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:4,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:6,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 15th 2020",dateEndSecondStepPublish:"December 15th 2020",dateEndThirdStepPublish:"February 13th 2021",dateEndFourthStepPublish:"May 4th 2021",dateEndFifthStepPublish:"July 3rd 2021",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"178218",title:"Dr.",name:"Awadesh",middleName:null,surname:"Mallik",slug:"awadesh-mallik",fullName:"Awadesh Mallik",profilePictureURL:"https://mts.intechopen.com/storage/users/178218/images/system/178218.jpg",biography:"Dr. Awadesh Kumar Mallik is a ceramic engineer from the University of Calcutta, India, who is currently a materials researcher. He started growing CVD diamond at the Indian Institute of Science Bangalore laboratory during his master’s thesis project for the development of vacuum tribology coatings for the Indian Space Research Organisation. He continued his scientific journey of making ceramic components for high-power electron tubes at the Council of Scientific and Industrial Research laboratory CGCRI as part of a national mission for the international fusion energy ITER program. He has executed and delivered several national and international projects. His research interests include diamond materials, thin films and coatings, CVD, PVD, tribology, bioceramics, ceramic membranes, fuel cells and batteries, ceramic powder processing, and materials science in general. He obtained a Ph.D. graduate from Jadavpur University, India, and completed an FWO postdoctoral research fellowship at Hasselt University, Belgium. He has published forty peer-reviewed articles and presented many papers at international conferences.",institutionString:"Hasselt University and IMEC VZW",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"University of Hasselt",institutionURL:null,country:{name:"Belgium"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"208",title:"Material Science",slug:"nanotechnology-and-nanomaterials-material-science"}],chapters:[{id:"76003",title:"Nonthermal Crystalline Forming of Ceramic Nanoparticles by Non-Equilibrium Excitation Reaction Field of Electron",doi:"10.5772/intechopen.97037",slug:"nonthermal-crystalline-forming-of-ceramic-nanoparticles-by-non-equilibrium-excitation-reaction-field",totalDownloads:230,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In this work, we have discovered a method of forming ZnO thin films with high mobility, high carrier density and low resistivity on plastic (PET) films using non-equilibrium reaction fields, even when the films are deposited without heating, and we have also found a thin film formation technique using a wet process that is different from conventional deposition techniques. The field emission electron-beam irradiation treatment energetically activates the surface of ZnO particles and decomposes each ZnO particles. The energy transfer between zinc ions and ZnO surface and the oxygen present in the atmosphere around the ZnO particles induce the oxidation of zinc. In addition, the ZnO thin films obtained in this study successfully possess high functional thin films with high electrical properties, including high hole mobility of 208.6 cm2/Vs, despite being on PET film substrates. These results contribute to the discovery of a mechanism to create highly functional oxide thin films using a simple two-dimensional process without any heat treatment on the substrate or during film deposition. In addition, we have elucidated the interfacial phenomena and crosslinking mechanisms that occur during the bonding of metal oxide particles, and understood the interfacial physical properties and their effects on the electronic structure. and surface/interface control, and control of higher-order functional properties in metal/ceramics/semiconductor composites, and contribute to the provision of next-generation nanodevice components in a broad sense.",signatures:"Norihiro Shimoi",downloadPdfUrl:"/chapter/pdf-download/76003",previewPdfUrl:"/chapter/pdf-preview/76003",authors:[{id:"341836",title:"Prof.",name:"Norihiro",surname:"Shimoi",slug:"norihiro-shimoi",fullName:"Norihiro Shimoi"}],corrections:null},{id:"74283",title:"Biomineralization of Magnetosomes: Billion-Year Evolution Shaping Modern Nanotools",doi:"10.5772/intechopen.94465",slug:"biomineralization-of-magnetosomes-billion-year-evolution-shaping-modern-nanotools",totalDownloads:393,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Biomineralization in the microbial realm usually gives origin to finely structured inorganic nanomaterials. Perhaps, one of the most elegant bioinorganic processes found in nature is the iron biomineralization into magnetosomes, which is performed by magnetotactic bacteria. A magnetosome gene cluster within the bacterial genome precisely regulates the mineral synthesis. The spread and evolution of this ability among bacteria are thought to be a 2,7-billion-year process mediated by horizontal gene transfers. The produced magnetite or greigite nanocrystals coated by a biological membrane have a narrow diameter dispersibility, a highly precise morphology, and a permanent magnetic dipole due to the molecular level control. Approaches inspired by this bacterial biomineralization mechanism can imitate some of the biogenic nanomagnets characteristics in the chemical synthesis of iron oxide nanoparticles. Thus, this chapter will give a concise overview of magnetosome synthesis’s main steps, some hypotheses about the evolution of magnetosomes’ biomineralization, and approaches used to mimic this biological phenomenon in vitro.",signatures:"Tarcisio Nascimento Correa, Igor Nunes Taveira, Rogerio Presciliano de Souza Filho and Fernanda de Avila Abreu",downloadPdfUrl:"/chapter/pdf-download/74283",previewPdfUrl:"/chapter/pdf-preview/74283",authors:[{id:"254251",title:"Dr.",name:"Fernanda",surname:"de Avila Abreu",slug:"fernanda-de-avila-abreu",fullName:"Fernanda de Avila Abreu"}],corrections:null},{id:"77960",title:"Nanostructuring Bi2Te3-Based Thermoelectric Thin-Films Grown Using Pulsed Laser Deposition",doi:"10.5772/intechopen.99469",slug:"nanostructuring-bi2te3-based-thermoelectric-thin-films-grown-using-pulsed-laser-deposition",totalDownloads:404,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This book chapter reports recent advances in nanostructured Bi2Te3-based thermoelectric (TE) thin-films fabricated by pulsed laser deposition (PLD). By controlling the processing conditions in PLD growths, various fascinating Bi2Te3-based nanostructured films with promising or enhanced TE properties have been successfully fabricated, including super-assembling of Bi2Te3 hierarchical nanostructures, self-assembled Bi2Te3 films with well-aligned 0D to 3D nanoblocks, polycrystalline-nanostructured Bi2Se3 and Bi2Te3 thin-films, etc. In addition, a PLD-growth mechanism for fabricating the super-assembling Bi2Te3 thin-films is presented. This book chapter provides fundamental understanding the relationship amongst processing condition, structure-morphology, and TE property of PLD-growths Bi2Te3-based thin-films. It also presents an overview of TE materials and applications with the challenges and perspectives.",signatures:"Le Thi Cam Tuyen, Phuoc Huu Le and Sheng-Rui Jian",downloadPdfUrl:"/chapter/pdf-download/77960",previewPdfUrl:"/chapter/pdf-preview/77960",authors:[{id:"187013",title:"Dr.",name:"Phuoc",surname:"Huu Le",slug:"phuoc-huu-le",fullName:"Phuoc Huu Le"},{id:"348310",title:"Dr.",name:"Le Thi Cam",surname:"Tuyen",slug:"le-thi-cam-tuyen",fullName:"Le Thi Cam Tuyen"},{id:"420973",title:"Prof.",name:"Sheng-Rui",surname:"Jian",slug:"sheng-rui-jian",fullName:"Sheng-Rui Jian"}],corrections:null},{id:"75563",title:"Characterization of Nanocrystalline Cores for EMI Suppression in Cables",doi:"10.5772/intechopen.96694",slug:"characterization-of-nanocrystalline-cores-for-emi-suppression-in-cables",totalDownloads:288,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Electromagnetic interferences (EMI) can cause different kinds of problems in digital and analog systems, leading to malfunctions, system reboots, or even permanent damage to the system if this is not adequately designed or protected. Nowadays, most electronic products are connected to the main power network or are designed to be interconnected with others through cables. These cable interconnections are becoming more difficult due to the rigid restrictions related to the accomplishment of electromagnetic compatibility (EMC) compliance. When the cables of a system represent an EMI source, it cannot pass the conducted or radiated emissions test. A widely used technique to reduce these problems is applying an EMI suppressor such as a sleeve core. This EMI suppressor provides selective attenuation of undesired interference components that the designer may wish to suppress, and it does not significantly affect the intended signal. This contribution focuses on analyzing different nanocrystalline (NC) EMI suppressors’ performance intended for attenuating interferences in cables. Some NC novel samples are characterized and compare to MnZn and NiZn cores to determine this novel material’s effectiveness compared to the conventional ceramic solutions by analyzing samples with different dimensions.",signatures:"Adrian Suarez, Jorge Victoria, Jose Torres, Pedro A. Martinez, Andrea Amaro and Julio Martos",downloadPdfUrl:"/chapter/pdf-download/75563",previewPdfUrl:"/chapter/pdf-preview/75563",authors:[{id:"2803",title:"Dr.",name:"Julio",surname:"Martos",slug:"julio-martos",fullName:"Julio Martos"},{id:"66221",title:"Dr.",name:"Jose",surname:"Torres",slug:"jose-torres",fullName:"Jose Torres"},{id:"193686",title:"MSc.",name:"Pedro A.",surname:"Martinez",slug:"pedro-a.-martinez",fullName:"Pedro A. Martinez"},{id:"193687",title:"Prof.",name:"Adrian",surname:"Suarez",slug:"adrian-suarez",fullName:"Adrian Suarez"},{id:"348209",title:"MSc.",name:"Jorge",surname:"Victoria",slug:"jorge-victoria",fullName:"Jorge Victoria"},{id:"348231",title:"BSc.",name:"Andrea",surname:"Amaro",slug:"andrea-amaro",fullName:"Andrea Amaro"}],corrections:null},{id:"76843",title:"Fullerenes and Nanodiamonds for Medical Drug Delivery",doi:"10.5772/intechopen.97867",slug:"fullerenes-and-nanodiamonds-for-medical-drug-delivery",totalDownloads:276,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Carbon is a chemical element has the ability of forming long carbonic chain. Due to its special electronic structure, each carbon atom can be linked with another carbon atom or with another element via single, double or triple covalent bonds. The special electronic structure of carbon atom affecting on its properties also affecting on its ability of existing in different forms called allotropes. During few last decades, new carbon-based nanomaterials have been described including fullerene, carbon nanotube, graphene and nanodiamond. These new allotropes attracted the interest of science and industry and became as a new and important class of materials due to its outstanding features which candidate for numerous applications. In parallel with new developments in nanomedicine especially in drug delivery field, the targeted delivery systems became an important to overcome the limitations of the old fashion systems. So, it become very important to translate this idea into reality. Fullerene and nanodiamond have a unique combination of structure, morphology and biological properties that make them as a powerful tools for targeted delivery system. So, this chapter will focus on two major aspects: synthesis routes of fullerenes and nanodiamonds, and their role in nanomedicine as drug delivery systems.",signatures:"Basma H. Al-Tamimi and Saad B.H. Farid",downloadPdfUrl:"/chapter/pdf-download/76843",previewPdfUrl:"/chapter/pdf-preview/76843",authors:[{id:"341563",title:"Dr.",name:"Basma H.",surname:"Al-Tamimi",slug:"basma-h.-al-tamimi",fullName:"Basma H. Al-Tamimi"},{id:"350855",title:"Prof.",name:"Saad",surname:"B. H. Farid",slug:"saad-b.-h.-farid",fullName:"Saad B. H. Farid"}],corrections:null},{id:"76027",title:"Nano-Sized Minerals from Lower Cretaceous Sandstones in Israel Observed by Transmission Electron Microscopy (TEM)",doi:"10.5772/intechopen.96948",slug:"nano-sized-minerals-from-lower-cretaceous-sandstones-in-israel-observed-by-transmission-electron-mic",totalDownloads:254,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Fine fraction in quartz arenite sandstones from Lower Cretaceous Hatira formation in Israel was observed by Transmission electron microscope (TEM). Samples were collected from Hatira and Ramon craters located in southern part of Israel and from Manara cliff from the northern part of Israel. The additional phases cause yellow, red, dark red and dark violet colors of the layered sandstones. The motivation was to identify the minerals of the fine factions that cause the variations in the colors. The minerals observed were clay minerals, mainly kaolinite (Al4Si4O20(OH)8), some illite (K0.65Al2.0[Al0.65Si3.35O10](OH)2) and smectite. Iron oxides were goethite (FeOOH) and hematite (Fe2O3), Titanium-iron oxides observed was ilmenite (FeTiO3), and Titanium-oxides were rutile (TiO2), and anatase (TiO2). Sulphates observed were jarosite (KFe3(SO4)2(OH)6) and alunite (KAl3(SO4)2(OH)6). Some of the hematite was formed by recrystallization of goethite. Ilmenite disintegrated into small iron oxides mainly hematite. Euhedral to sub-hedral rutile (TiO2) and anatase (TiO2) were preserved in clay-minerals. Crystals of alunite and jarosite were observed in sandstones in both craters. They probably crystallized due to some transgression of the Thetis Sea.",signatures:"Nurit Taitel-Goldman and Vladimir Ezersky",downloadPdfUrl:"/chapter/pdf-download/76027",previewPdfUrl:"/chapter/pdf-preview/76027",authors:[{id:"161472",title:"Dr.",name:"Nurit",surname:"Taitel-Goldman",slug:"nurit-taitel-goldman",fullName:"Nurit Taitel-Goldman"},{id:"354267",title:"Dr.",name:"Vladimir",surname:"Ezersky",slug:"vladimir-ezersky",fullName:"Vladimir Ezersky"}],corrections:null},{id:"76267",title:"Diluted Magnetic Semiconductors Nanocrystals: Saturation and Modulation",doi:"10.5772/intechopen.96679",slug:"diluted-magnetic-semiconductors-nanocrystals-saturation-and-modulation",totalDownloads:290,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Diluted Magnetic Semiconductor (DMS) nanocrystals are a new class of materials formed by doping the semiconductor with transition metals (TM), which gives interesting magneto-optical properties. These properties are attributed to the exchange interaction between the pure semiconductor’s sp-electrons and the localized TM d-electrons. This book chapter shows exciting results of new DMS developed by the group, both in powder form and embedded in glassy systems. Depending on the concentration of doping ions, saturation of the incorporation of substitutional and interstitial sites in the nanocrystal structure may occur, forming other nanocrystals. In this context, we investigated the doping saturation limit in nanopowders of DMS Zn1-xMnxO NCs and Zn1-xMnxTe, Zn0.99-xMn0.01CoxTe, and Bi2-xCoxS NCs synthesized in glassy matrices. Thus, the sites’ saturation into the crystalline lattice of nanocrystals is a topic little reported in the literature, and we will comment on this work. Therefore, we will show results from the group about the modulation and saturation in diluted magnetic semiconductors nanocrystals in this work.",signatures:"Anielle C.A. Silva, Amanda I.S. Barbosa, Alessandra S. Silva, Elisson A. Batista, Thaís K. de Lima Rezende, Éder V. Guimarães, Ricardo S. Silva and Noelio O. Dantas",downloadPdfUrl:"/chapter/pdf-download/76267",previewPdfUrl:"/chapter/pdf-preview/76267",authors:[{id:"340051",title:"Prof.",name:"Anielle C.A.",surname:"Silva",slug:"anielle-c.a.-silva",fullName:"Anielle C.A. Silva"},{id:"346696",title:"Dr.",name:"Alessandra S.",surname:"Silva",slug:"alessandra-s.-silva",fullName:"Alessandra S. Silva"},{id:"346697",title:"Dr.",name:"Éder V.",surname:"Guimarães",slug:"eder-v.-guimaraes",fullName:"Éder V. Guimarães"},{id:"346698",title:"Prof.",name:"Ricardo S.",surname:"Silva",slug:"ricardo-s.-silva",fullName:"Ricardo S. Silva"},{id:"346701",title:"Prof.",name:"Noelio",surname:"Dantas",slug:"noelio-dantas",fullName:"Noelio Dantas"},{id:"347625",title:"MSc.",name:"Amanda I. S.",surname:"Barbosa",slug:"amanda-i.-s.-barbosa",fullName:"Amanda I. S. Barbosa"},{id:"347626",title:"Dr.",name:"Elisson A.",surname:"Batista",slug:"elisson-a.-batista",fullName:"Elisson A. Batista"},{id:"347627",title:"MSc.",name:"Thaís",surname:"K. de Lima Rezende",slug:"thais-k.-de-lima-rezende",fullName:"Thaís K. de Lima Rezende"}],corrections:null},{id:"75698",title:"Doped Semiconductor Nanocrystals: Development and Applications",doi:"10.5772/intechopen.96753",slug:"doped-semiconductor-nanocrystals-development-and-applications",totalDownloads:296,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter aims to show significant progress that our group has been developing and the applications of several doped semiconductor nanocrystals (NCs), as nanopowders or embedded in glass systems. Depending on the type of dopant incorporated in the nanocrystals, the physical, chemical, and biological properties can be intensified. However, it can also generate undesired toxic effects that can potentially compromise its use. Here we present the potential of zinc oxide NCs doped with silver (Ag), gold (Au), and magnesium (Mg) ions to control bacterial diseases in agriculture. We have also performed biocompatibility analysis of the pure and Ag-doped sodium titanate (Na2Ti3O7) NCs in Drosophila. The doped nanocrystals embedded in glassy systems are chrome (Cr) or copper (Cu) in ZnTe and Bi2Te3 NCs for spintronic development nanodevices. Therefore, we will show several advantages that doped nanocrystals may present in the technological and biotechnological areas.",signatures:"Anielle C.A. Silva, Eliete A. Alvin, Francisco R.A. dos Santos, Samanta L.M. de Matos, Jerusa M. de Oliveira, Alessandra S. Silva, Éder V. Guimarães, Mirella S. Vieira, Eurípedes A. da Silva Filho, Ricardo S. Silva, Lucas Anhezini, Nilvanira D. Tebaldi and Noelio O. Dantas",downloadPdfUrl:"/chapter/pdf-download/75698",previewPdfUrl:"/chapter/pdf-preview/75698",authors:[{id:"340051",title:"Prof.",name:"Anielle C.A.",surname:"Silva",slug:"anielle-c.a.-silva",fullName:"Anielle C.A. Silva"},{id:"346696",title:"Dr.",name:"Alessandra S.",surname:"Silva",slug:"alessandra-s.-silva",fullName:"Alessandra S. Silva"},{id:"346697",title:"Dr.",name:"Éder V.",surname:"Guimarães",slug:"eder-v.-guimaraes",fullName:"Éder V. Guimarães"},{id:"346698",title:"Prof.",name:"Ricardo S.",surname:"Silva",slug:"ricardo-s.-silva",fullName:"Ricardo S. Silva"},{id:"346701",title:"Prof.",name:"Noelio",surname:"Dantas",slug:"noelio-dantas",fullName:"Noelio Dantas"},{id:"221975",title:"Dr.",name:"Jerusa M.",surname:"de Oliveira",slug:"jerusa-m.-de-oliveira",fullName:"Jerusa M. de Oliveira"},{id:"346692",title:"Prof.",name:"Eurípedes A.",surname:"da Silva Filho",slug:"euripedes-a.-da-silva-filho",fullName:"Eurípedes A. da Silva Filho"},{id:"346700",title:"Prof.",name:"Lucas",surname:"Anhezini",slug:"lucas-anhezini",fullName:"Lucas Anhezini"},{id:"346981",title:"MSc.",name:"Eliete A.",surname:"Alvin",slug:"eliete-a.-alvin",fullName:"Eliete A. Alvin"},{id:"347305",title:"Mr.",name:"Francisco",surname:"R.A. dos Santos",slug:"francisco-r.a.-dos-santos",fullName:"Francisco R.A. dos Santos"},{id:"348389",title:"Ms.",name:"Samanta L.M.",surname:"de Matos",slug:"samanta-l.m.-de-matos",fullName:"Samanta L.M. de Matos"},{id:"348390",title:"Ms.",name:"Mirella S.",surname:"Vieira",slug:"mirella-s.-vieira",fullName:"Mirella S. Vieira"},{id:"348391",title:"Prof.",name:"Nilvanira D.",surname:"Tebaldi",slug:"nilvanira-d.-tebaldi",fullName:"Nilvanira D. Tebaldi"}],corrections:null},{id:"77799",title:"Antimicrobial Efficacy of Biogenic Silver and Zinc Nanocrystals/Nanoparticles to Combat the Drug Resistance in Human Pathogens",doi:"10.5772/intechopen.99200",slug:"antimicrobial-efficacy-of-biogenic-silver-and-zinc-nanocrystals-nanoparticles-to-combat-the-drug-res",totalDownloads:174,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The emergence of biogenic nanomaterials as novel antimicrobials introduces a new paradigm in human health care. Based on the recent reports of the World Health Organization, infectious diseases pose one of the greatest health challenges. Increased multi-drug resistance prevalence among human pathogens, due to the inefficiency of commercially available antimicrobial drugs in the market is a great threat to humans. The poor solubility, stability and side effects of the antibacterial therapy prompted the researchers to explore new innovative strategies for developing new antimicrobials. Recently, biogenic nanoparticles have proven their effectiveness against multidrug-resistant (MDR) pathogens as an alternative to conventional antibiotics. Biogenic nanoparticles such as silver nanoparticles (AgNPs) and Zinc Oxide nanoparticles (ZnONPs) are easy to produce, biocompatible, provide enhanced uptake and are eco-friendly. Moreover, the capping of the biogenic nanocrystals provides an active surface for interaction with biological components, facilitated by free active surface functional groups to enhance their efficacy and delivery. Inorganic nanocrystals (AgNPs and ZnONPs) are effective both as nano-bactericides and as nanocarriers against sensitive and MDR) pathogens. The present chapter focuses on the utilization of the recent nanosystems to combat drug resistance in human pathogens. Nanomedicine represents a new generation of potiential antimicrobial candidates capable of combating the drug resistance in various pathogenic organisms.",signatures:"Gulzar Ahmed Rather, Saqib Hassan, Surajit Pal, Mohd Hashim Khan, Heshu Sulaiman Rahman and Johra Khan",downloadPdfUrl:"/chapter/pdf-download/77799",previewPdfUrl:"/chapter/pdf-preview/77799",authors:[{id:"226198",title:"Dr.",name:"Johra",surname:"Khan",slug:"johra-khan",fullName:"Johra Khan"},{id:"253612",title:"Dr.",name:"Heshu Sulaiman",surname:"Rahman",slug:"heshu-sulaiman-rahman",fullName:"Heshu Sulaiman Rahman"},{id:"347400",title:"Mr.",name:"Gulzar Ahmed",surname:"Rather",slug:"gulzar-ahmed-rather",fullName:"Gulzar Ahmed Rather"},{id:"353075",title:"Mr.",name:"Mohd Hashim",surname:"Khan",slug:"mohd-hashim-khan",fullName:"Mohd Hashim Khan"},{id:"418490",title:"Dr.",name:"Saqib",surname:"Hassan",slug:"saqib-hassan",fullName:"Saqib Hassan"},{id:"421881",title:"Mr.",name:"Surajit",surname:"Pal",slug:"surajit-pal",fullName:"Surajit Pal"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"10257",title:"Engineering Applications of Diamond",subtitle:null,isOpenForSubmission:!1,hash:"6062b591f89e8bdbbd8e7f59c0d366a1",slug:"engineering-applications-of-diamond",bookSignature:"Awadesh Mallik",coverURL:"https://cdn.intechopen.com/books/images_new/10257.jpg",editedByType:"Edited by",editors:[{id:"178218",title:"Dr.",name:"Awadesh",surname:"Mallik",slug:"awadesh-mallik",fullName:"Awadesh Mallik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7640",title:"Perspective of Carbon Nanotubes",subtitle:null,isOpenForSubmission:!1,hash:"8b85a9957fad5206369eadf0c1ffa27d",slug:"perspective-of-carbon-nanotubes",bookSignature:"Hosam El-Din Saleh and Said Moawad Mohamed El-Sheikh",coverURL:"https://cdn.intechopen.com/books/images_new/7640.jpg",editedByType:"Edited by",editors:[{id:"144691",title:"Prof.",name:"Hosam M.",surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. 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D in Physics in 2012 from Indian Institute of Technology Guwahati, India. Presently, he is associated with the Faculty of Science, Sri Sri University, India as an Assistant Professor in Physics. Prior to joining the current\naffiliation, he was a postdoctoral fellow at different renowned institutions, Kobe University Japan, S. N. Bose National Centre for Basic Sciences, India and Cardiff University, United Kingdom. He was awarded prestigious JSPS postdoctoral fellowship based on his research contribution on semiconducting nanowires. He has published more than 32 research articles including 1 review article in high profile international journals and 3 book chapters to his credit. 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Actually the ferroelectricity at nanoscale receives a great attention to the development of new technologies. The demand for ferroelectric systems with specific applications enforced the in-depth research in addition to the improvement of processing and characterization techniques. This book contains twenty two chapters and offers an up-to-date view of recent research into ferroelectricity. The chapters cover various formulations, their forms (bulk, thin films, ferroelectric liquid crystals), fabrication, properties, theoretical topics and ferroelectricity at nanoscale.",isbn:null,printIsbn:"978-953-51-0885-6",pdfIsbn:"978-953-51-6280-3",doi:"10.5772/45744",price:159,priceEur:175,priceUsd:205,slug:"advances-in-ferroelectrics",numberOfPages:544,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"4706ad2bc11c32090c362c0026f67d37",bookSignature:"Aimé Peláiz Barranco",publishedDate:"November 19th 2012",coverURL:"https://cdn.intechopen.com/books/images_new/3210.jpg",keywords:null,numberOfDownloads:61232,numberOfWosCitations:74,numberOfCrossrefCitations:39,numberOfDimensionsCitations:84,numberOfTotalCitations:197,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 3rd 2012",dateEndSecondStepPublish:"April 24th 2012",dateEndThirdStepPublish:"July 21st 2012",dateEndFourthStepPublish:"August 20th 2012",dateEndFifthStepPublish:"November 19th 2012",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"10 years",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:"Edited by",kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"14679",title:"Dr.",name:"Aimé",middleName:null,surname:"Peláiz-Barranco",slug:"aime-pelaiz-barranco",fullName:"Aimé Peláiz-Barranco",profilePictureURL:"https://mts.intechopen.com/storage/users/14679/images/3416_n.jpg",biography:"Dr. Aimé Peláiz Barranco is a professor in the Physics Faculty, Havana University, Cuba. Her activities range from teaching,to advising undergraduate and graduate students and doing high quality research. She is one of the leaders in the development of ferroelectric and antiferroelectric materials research in Cuba. She has authored several scientific papers in refereed journals and presented an important number of research works at national and international conferences. Her results have been recognized in Cuba and worldwide through several awards, such as TWOWS Award for Young Women Scientists in Physics/Mathematics (2010) and TWAS-ROLAC Award for Young Scientists in Physics (2011). 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Current world population exceeds 7200 million people and it is expected to reach 9.6 billion in 2050 [1]. The population growth is greatest in developing countries, with the consequent increase in pressure on the use of natural resources, in response to food demand and other services. Arid zones are among the top issues due to their territorial extension and the abundance and diversity of their natural resources. These regions represent one of the most viable options to respond to the challenges of the twenty‐first century. However, there is a need for a systemic and comprehensive vision of the potential limitations that exist in these areas, which involves identification of current and future conditions on the state of natural resources, as a basis for the design and implementation of development plans. Globally, one of the challenges in this century is to reduce poverty in developing countries. One possibility to reach this goal is through a better management of natural resources involved in food production, such as water and soil, as well as the conservation of biodiversity, and the restoration of fragile ecosystems from the arid zones.
\nThe socio‐ecological systems in arid lands cover approximately 45% of the planet’s surface, where about 2 billion people live, accounting for 33.8% of the world population [2–4]. In these regions, a critical situation is the depression of the local economies because of the impacts of the drought on economic activities and the natural resources, mainly water, soil, and native plants and animals, expressed in processes of desertification. These processes are expanding and Mexico will be one among the most affected countries. Thus, it is predicted that in 2050, rainfall and irrigated maize production will be reduced by 17 and 8%, respectively; while wheat production under rainfall systems could be reduced by 19% and in systems under irrigation by 8% [5].
\nThe Mexican desert covers more than 50% of the national surface, which has different degrees of aridity typified by the characteristics of rainfall [6]. In this area, around 18% of the national population is located [7]. Moreover, the larger water demands are in the north and center of the country, which becomes a problem, since Mexico presents a territorial contrast of shortage and abundance of water [8]; while in southern Mexico frequent floods occur, in Northern Mexico, rainfall is very irregular and scarce. Then, the country is divided into two large areas: (1) Northern, central and northeast, where 77% of the population is concentrated, and 80% of gross domestic product (GDP) is generated in this region, but only 31% is renewable water. (2) Southern and southeast, where 23% of the population lives there, and only 20% of GDP is generated, but in this place, occurs 69% of renewable water [9].
\nA proper use of the natural resources in a region may be reached by a micro‐regionalization, which allows one to know the amount of small areas that integrate any zone with natural similarities within each micro‐region.
\nThe agroecological zoning is a methodology aimed at the evaluation of soil resources that integrates the use of geographic information systems. It has been applied in several countries and has been adopted as the method of evaluation of soil resources. This methodology is used in a holistic focus in territorial planning projects, and is a tool proposed by the AEZ methodology combined with the geographical information systems [10].
\nThe development of cartographic procedures to obtain agroecological zoning is a current issue related to the concept of sustainability. These tools present the spatial classification of a territory per its potential capabilities, such as: production and protection zones, zone restoration, and identification of optimal areas for the intensive development of commercial plantations, among other uses. Thus, the decision takers may design plans to make better use and management of natural resources, such as biotic resource to increase profits, but also to improve and increase the existing natural capital over time.
\nAEZ/SIG methodology separates areas based on combinations of soil, physiography, and climate. This tool has several applications for land characteristics and types of uses such as potential land productivity, risk assessment of degradation, environmental impact assessment estimation of arable land, among others [11]. Most AEZ/SIG studies identify the types of land use (TLU) regarding crops or range of crops and input levels [12].
\nThe middle watershed Nazas‐Aguanaval region of the country is an area of the Chihuahuan desert, where ecosystems and agro‐ecosystems with environmental, economical, and social importance are located. Beyond regionalization somewhat generic, the middle watershed Nazas‐Aguanaval does not have a project of specific regionalization, based on an integrative approach from the physical and biological point of view, to allow better planning of natural resources directly related to regional development processes. This is important, given the need for greater agricultural production and, at the same time, to make more rational use of resources with minimal or no adverse environmental impacts. In this case of study [13], different indicators were used to make the comprehensive characterization of a region, considering both physical factors and the most important biological factor [14]. Aridity index, index of seasonal drought, vegetation, and type of soil were the indicators used for the survey of regionalization. Steps of study: (1) The middle watershed Nazas‐Aguanaval map was generated with digital sub‐watersheds [15] and the boundaries that are defined between the Francisco Zarco and Lázaro Cárdenas dams, shunt, and storage of RH 36, respectively (\nFigure 1A\n); (2) From the National Weather Service, we obtained the climatic stations for the middle watershed Nazas‐Aguanaval of the states of Durango and Zacatecas, Mexico, which were geo‐referenced (\nFigure 1B\n); (3) Applying the program [16] and the INEGI data base [15], the physiographic (vegetation and soil) characteristics of the middle watershed Nazas‐Aguanaval were identified, using the digital information from the native vegetation and soil scale 1:250,000 (\nFigure 2A\n and \nB\n); (4) Interpolation was performed by the inverse distance weighted (IDW) method with the ArcMapTM 10.1 software to obtain the drought and aridity index using a raster graphics.
\nMiddle watershed Nazas‐Aguanaval and sub‐watersheds (A) geo‐referencing climatic stations, marked with black dots (B) (Source: Compiled by author based on maps available at [
Types of vegetation (A) and types of soil (B) in the middle watershed Nazas‐Aguanaval (Source: Compiled by author based on maps available at [
The different micro‐regions were identified based on the degree of aridity. We used the Emberger aridity index modified by Stretta and Mosiño [17], which integrates the predominant action of the rainfall regime and the influence of the maximum and minimum average temperatures of the hottest and coldest, respectively. For the calculation of the aridity condition, the series of historical climatological data (1979–2008 of the National Meteorological Service) of 26 climatic stations in the study area was used (\nFigure 3A\n).
\nLevels of aridity (A) and spatial distribution of seasonal drought in the middle watershed Nazas‐Aguanaval (B). (Source: Compiled by authors).
Annual drought regionalization and its intensity were calculated through the water precipitation information, which was collected from the 26 climactic stations with complete data for every year [18]. The number of years with drought was recorded for the selected seasons. A scale in percentage of years in the presence of drought was established to categorize the levels (\nFigure 3B\n).
\nThe categorization proposed by integrating the indicators mentioned above arises from the possible combinations of the different levels of each regionalization approach, resulting in the following micro‐regions:
\n\n
The identification of the 15 micro‐regions of the study area, should allow planning a more targeted and systematic use of natural resources, based on the biophysical characteristics. A planning process with different purposes, such as: conservation, development and/or production of biotic resources in arid zones. According to different authors [19–21], regionalization is the best planning tool, especially when integrating different biophysical indicators such as the type of soil, type of native vegetation, frequency of droughts and aridity conditions (\nFigure 4\n).
\nMicro‐regions resulting in the central‐north region of Durango by type of vegetation and soil, degree of aridity and intensity of temporary drought (Source: Compiled by authors).
Through soils with low productive capacity and crops with high resistance to water stress could be possible to define areas for productive reconversion. The criteria include water harvesting and the use of some humidity retainers to increase the water holding capacity of the soil. Of this way is possible to promote the gradual recovery of the soil cover reducing soil and wind erosion, which are the main problems related to soil productivity in arid lands.
\nDesertification occurs because of the degradation of natural ecosystems in dry lands, which is a big global problem. Soil degradation causes may be included into three broad aspects: (a) physical, where climate plays a big role in terms of floods, droughts that enhance soil erosion; (b) chemical, generally in the form of salinization; and (c) biological, mainly as a result of the oxidation of the organic matter of the soil [22].
\nThe main consequences of land degradation are chemical degradation of the soil, related to soil chemical contamination with several toxic elements like heavy metals and salts, which makes loss of vegetative cover, loss of soil surface layer infiltration, reduction of water storage in the soil, loss of soil organic matter, fertility and structure, loss of soil elasticity, loss of natural regeneration, and decrease of water level. Degradation affects most of the arid zones, mainly in marginal cultivated areas [11].
\nMost of the world’s dry lands are degraded. In Mexico, estimates of the magnitude of degradation may differ from the methods used to calculate them. Even though, there are not specific studies on the extent of desertification in Mexico, the approach of this chapter considers soil degradation as an estimator of desertification recognizing the limitation, since only one considers its elements. On the other hand, the information included data back to 10 years [23].
\nBefore making any practices for planting native vegetation species that rehabilitate degraded soils in arid zones, are necessary to select wisely the species to grow. The aim of this part of study was to select species that meet the environmental conditions. Once the main problem is identified, the resource management system (RMS) planning tool provides a series of alternatives to cope with those problems. These alternatives were adjusted according the specific conditions encountered in the field [24].
\nThe usefulness of the RMS planning tool is to perform a decision matrix composed by the resource concern and the alternatives. The soil, water, animals, plants atmosphere humans (SWAPAH) serves this purpose after a series of problems have been identified in the field. The tool provides a series of alternatives that are evaluated according to its impact on the resource concern. Therefore, a group of professionals select those alternatives with the less negative impact (or the more positive impact) on the resource. These selected alternatives are then emigrated to a decision support system, which are evaluated according to several criteria imposed by the participants (professionals and those users directly impacted by the decision). For standardizing the scores from 0 to 1 given to the criteria, a scoring function should be selected among: more is better linear, more is better nonlinear, more is worst linear, and desirable range [25, 26]. To facilitate the use of the software, the user is presented with the shapes of these functions from where one should be selected [25, 26].
\nPhysical, social, economic, and environmental factors were included in this methodology. The best evaluated practices for their feasibility, viability, and ease of implementation were: grow woody plants (
Drylands are of high ecological vulnerability due to low vegetative cover and erratic and torrential rainfall. The aim of this study was to evaluate the use of different sources and dosages of soil moisture retainers in planting buffel grass (
Micro‐watershed for water harvesting; when was built (A), and after, when the grass has grown (B).
At 241 days after planting (DAP), the soil moisture content was higher, and then decreased to 346 and 372 DAP, with average values of 22.5, 16.8, and 8.2%, respectively (\nFigure 6\n). This trend is related to the rainfall with drought during May and June of the study year, followed by a period, also with relative drought during July and August, but in general this year (2013) was lack of rainfall since the annual average was only 205.4 mm (\nFigure 7\n) [28]. Although the response function showed a negative rate, and showed differences at all three sampling dates, the soil moisture content was always higher when the hydrogel was applied at least for the first two sampling dates (241 and 346 DAP), with values on the first date (241 DAP) of 25, 23.2, and 23.4% when applying 5, 10, and 15 kg ha−1, respectively, vs 17.5 % when the hydrogel was not applied. A similar pattern was shown in the second sampling date (346 DAP); while at 372 DAP, which was not affected by moisture retention, and the different dosages of hydrogel (\nFigure 8\n). This means that about 157 days after the first sample without a significant rainfall, the effect of soil moisture retention of the hydrogel stopped, arising near the soil wilting point (WP) level. Thus the effect of the hydrogel was identified at least in the first two samples in any dosages included in this study, and the lower dosages of hydrogel (5–10 kg ha−1) may be used to obtain the same results. Before partially is disagree to [29], who used dosages of 0, 20, 30 and 40 g of hydrogel in 130 g of sand, the higher dosages of hydrogel showed the best results as retainers of soil moisture [24].
\nSoil moisture content at different sampling dates in days after planting (DAP) (2013).
Rainfall during 2013 in the area near to the experimental area to Bermejillo, Dgo, México.
Soil moisture content with different dosages of hydrogel and sampling dates (DAP) (2013).
Seedling emergence was 47.7%, when 15 kg ha−1 of hydrogel was applied, compared to 29% when it was not applied. The dosages of 5 and 10 kg ha−1 had intermediate values, with no statistical difference (\nFigure 9\n). These results are consistent with those reported by Rojas et al. [30] regarding the use of hydrogel, which had a positive effect on the capacity of germination of tomato (
Effect of hydrogel dosages on germination percentage of buffel grass in micro‐watershed for water harvesting, during August, 2012.
The lower dosages of hydrogel (5–10 kg ha−1) used in this study were less effective in seedling emergence, which could mean that at this stage of development of buffel grass, high moisture content is required in the soil, which is expressed to a dose of 15 kg ha−1. There was no effect on the compost on seed germination of grasses. Even with the low rainfall regime in 2012 and the absence of the treatment effect on the moisture content in the soil, the growth of buffel grass remained constant, with significant growth in each evaluation date, at an exponential rate of 1.7 cm d−1 (\nFigure 10A\n). This is an indicator of the high adaptability of this forage species under drought [31, 32]. Similar behavior was observed with grass development during 2013, with an exponential growth rate of 1.5 cm d−1 (\nFigure 10B\n). The height of the plant was significantly major in both dosages of hydrogel and consequently the dry matter weight too.
\nGrowth of buffel grass in rainwater capturing watersheds, at different evaluation times during 2012 (A) and 2013 (B).
Development buffel grass is dependent on the soil water content, but is tolerant to drought stress [33]. In this sense, hydrogel showed better effects enhancing plant growth and increasing biomass production in other crops as beet (
Photosynthetic activity and transpiration of the plant were measured by the C02and H20 flow, respectively using the infrared gas analysis (IRGA) model LICOR‐6400. The photosynthesis was significantly higher in the dosages of 15 kg ha−1 of hydrogel at a rate of assimilation 6.67 mmol CO2 m−2 s−1, compared to the assimilation rate obtained when the product was applied to 5 or 10 kg ha−1 or not applied, with values of 3.7, 3.8, and 4, respectively. Higher photosynthesis rates were associated with greater conductance and transpiration, and vice versa (\nTable 1\n). Thus, the presence of moisture in the soil promotes plant photosynthetic activity, while water deficits decrease it [36]. The photosynthetic activity of the grass was strongly influenced by the condition of soil moisture; this was identified on November 6, 2013, with an average soil moisture of 18.4% when the hydrogel was applied, with no statistical differences between the dosages. All this indicates that the moisture content in the soil is influenced by hydrogel (\nTable 1\n).
\nHydrogel doses | \nSoil moisture content (%) | \nPhotosynthesis (μmol m−2 s−1) | \nConductance (mol m−2 s−1) | \nTranspiration (mmol H2O m−2 s−1) | \n
---|---|---|---|---|
\n | \n16.4b | \n3.72b | \n0.0055b | \n0.214c | \n
\n | \n19.5a | \n3.82b | \n0.0089a | \n0.227bc | \n
\n | \n17.2ab | \n4.05ab | \n0.0066ab | \n0.255b | \n
\n | \n18.4a | \n6.67a | \n0.0099a | \n0.382a | \n
Effect of hydrogel on photosynthetic activity and other physiological variables on buffel grass (
Tukey test (
The aim of this study was to evaluate different soil moisture retention practices in the survival and growing grass (
A number of seeds germinated
Germination rate in pastures
The moisture content was higher when applying hydrogel at 15 days after the rain (DAR) at each soil depth evaluated. This effect disappeared after evaluation dates without significance among hydrogel treatments for both soil depths (\nFigure 12\n). Hydrogel offers better water release properties when combined with soil and retains larger amounts of water, either under instant or prolonged irrigation conditions, and maintains moisture at a higher value in crops [40]. These results differ from those found for other research studies [41], who found higher soil moisture content when applying hydrogel to a soil depth of 0 – 15 cm, in relation to the control, throughout the rice growing season. Also the hydrogel improves the rapidly available water capacity (RAWC) of soils; although the effectiveness of the gel in improving soil water retention varies for different soil types [42].
\nMoisture reduction at 30 cm (A) and 45 cm (B) depth of soil in different hydrogel contents and different sampling dates: 15, 30, 45, and 60 days after the rainfall. Tukey test (
Moisture retention characteristics of the hydrogel are inherent to constant hydration, a condition that was not present at the study site due to low rainfall; in other hand, the occurrence of precipitation for arid and semi‐arid zones is not homogeneous, and highly variable in time. Regarding the application of dry corn stubble, the moisture content at both evaluated depths remained higher at each evaluation date than the harvest residue was not added (\nFigure 13\n). The useful moisture range for this type of soil is 18%, since the field capacity (FC) is 33% and the permanent wilting point (PWP) is 15%. In the treatment without stubble application reached values of 16% always, very close to PWP. Application of dry corn stubble maintained soil moisture content higher than 18% always, with a lower rate of humidification than the treatment without stubble an average of both soil depths (30 and 40 cm); the treatment with corn stubble obtained 3.7 and 3.1% more moisture content than the control at 30 cm and 45 cm depth, respectively.
\nMoisture reduction at 30 cm (A) and 45 cm (B) depth of soil associated with dry corn stubble doses and different sampling dates: 15, 30, and 45 and 60 days after rainfall. Tukey test (
The percentage of survival of the grass was significantly different from the species (\nFigure 14\n). Both
Percentage of survival by grass species with application of 10 t ha−1of stubble and without application of stubble; application of hydrogel at doses of 20 kg ha−1, 10 kg ha−1, and 0 kg ha−1. Vertical bars represent the standard deviation ±. Columns with equal letters are not statistically different (
The percentage of survival of the grasses when applying hydrogel was significantly higher, compared to no application; 89.3% and 76.4% of survival were found for the doses 20 and 10 kg ha−1, respectively, without statistical difference between them. Similar results showed treatments with stubble application, the percentage of survival was significantly higher, when applying corn stubble (89.9%), with respect to that when it was not applied (81.2%) (\nFigure 13\n). Similar results have been reported, when vegetation cover is not applied, the percentage of forest species survival is significantly reduced to 66.7% [45].
\nDry stubble coverage at doses 10 t ha−1 significantly influenced the plant height, number of tillers, and chlorophyll index and plant vigor of the grass species during different evaluation dates (\nTable 2\n). The introduced grass was superior in all variables with respect to the native grass. Studies with stubble use showed effects with the addition of mulch or peat cover on peanut cultivation, significantly influencing some agronomic attributes of crop growth and yield [46].
\nDose of retainer of soil water | \nNumber of tillers | \nPlant height (cm) | \nCCI | \nVigor (0–5) | \n||||
---|---|---|---|---|---|---|---|---|
BC | \nCG | \nBC | \nCG | \nBC | \nCG | \nBC | \nCG | \n|
Hydrogel | \n||||||||
0 kg ha−1\n | \n5.6a ±1.0 | \n3.5a ±0.8 | \n26.9a ±4.8 | \n33.1a ±4.8 | \n98.6a ±5.3 | \n114.3a ±5.1 | \n3.7a ±0.5 | \n4.1a ±0.6 | \n
10 kg ha−1\n | \n5.7a ±0.9 | \n3.6a ±0.9 | \n27.7a ±5.2 | \n34.9a ±4.6 | \n95.9a ±4.7 | \n113.2a ±5.7 | \n3.3a ±0.7 | \n4.5a ±0.7 | \n
20 kg ha−1\n | \n5.9a ±1.1 | \n3.2a ±0.9 | \n27.2a ±4.3 | \n32.6a ±3.6 | \n97.8a ±4.3 | \n109.8a ±6.2 | \n3.5 a ±0.4 | \n4.3a ±0.5 | \n
Dry stubble coverage | \n||||||||
0 t ha−1\n | \n4.4b ±0.9 | \n3.0b ±0.7 | \n22.6b ±2.6 | \n29.5b ±3.1 | \n84.4b ±6.4 | \n107.8b ±6.7 | \n4.0± 0.4 b\n | \n3.8b ±0.5 | \n
10 t ha−1\n | \n7.1a ±0.8 | \n3.8a ±0.8 | \n31.9 a ±3.3 | \n37.2a ±3.4 | \n98.5a ±5.9 | \n121.5a ±7.4 | \n2.9a ±0.7 | \n4.7a ±0.3 | \n
Growing variables in two grass species in different hydrogel doses and dry stubble coverage.
BC =
Plant growth, forage yield of the guinea grass was increased when straw in saline soils was applied [47]. Also Ref. [48] identified that the incorporation of mulch to the soil for establishment of grasses, had superior results, related to maximized vegetation of grasses and greater amount of biomass, regarding the treatments without addition of straw.
\nThe effect of stubble was related to higher and evenly distributed soil moisture content, which allowed a better yield of biomass in each evaluation. In contrast, the hydrogel showed only statistical differences at 30 days after the transplantation when applying 10 or 20 ton ha−1, without statistical difference in the first dose with the control, in the case of
Dose of retainer of soil water | \nDry weight of biomass (g) | \n|||||
---|---|---|---|---|---|---|
30 DAT | \n45 DAT | \n60 DAT | \n||||
\n | BC | \nCG | \nBC | \nCG | \nBC | \nCG | \n
Hydrogel | \n||||||
0 kg ha−1\n | \n11.0b ±1.7 | \n17.5b ±3.3 | \n45.1a ±6.0 | \n57.9a ±5.5 | \n53.3a ±7.1 | \n68.0a ±7.0 | \n
10 kg ha−1\n | \n13.3ab ±2.2 | \n24.3a ±4.1 | \n42.8a ±5.9 | \n56.0a ±5.8 | \n51.5a ±6.3 | \n66.8a ±7.6 | \n
20 kg ha−1\n | \n14.7a ±2.0 | \n25.6a ±4.9 | \n44.7a ±5.3 | \n56.9a ±4.2 | \n51.6a ±6.2 | \n67.7a ±5.8 | \n
Dry stubble corn | \n||||||
0 t ha−1\n | \n12.3b ±2.1 | \n20.4b ±1.6 | \n39.8b ±3.3 | \n52.3b ±2.7 | \n47.2b ±4.4 | \n61.1b ±2.8 | \n
10 t ha−1\n | \n16.1a ±0.9 | \n28.6a ±1.9 | \n48.8a ±3.9 | \n61.1a ±2.8 | \n57.2a ±4.5 | \n73.2a ±3.2 | \n
Biomass production in two grass species to different hydrogel and dry stubble corn dosages.
BC =
Ecological zoning through indicators such as aridity, drought, type of vegetation, and type of soil use is often an effective tool in a more systematic and targeted application of technologies for a better management of natural resources, according to the potential of each small region.
\nWater is the most limited natural resource and therefore of major importance to be considered in development plans in arid lands to optimize the use of this resource and avoid environmental deterioration such as soil degradation, turning productive areas into unproductive ones.
\nAn integrated system, such as use of water stress tolerant plant species, rainwater harvesting, and soil moisture retention practices, like the experiences and results shown in this chapter, may be the useful tools for the productive reconversion of areas degraded in arid lands.
\nExploration and integrating technological practices focused on promoting effective management of natural resources in ecosystems and agro‐ecosystems, is a current an issue where the main constraint is water.
\nWe want to thank to Chapingo Autonomous University for financial support to carry out the research related to the topic of the mitigation of degraded soils in arid zones, as well as to the National Institute of Agricultural Livestock and Forestry Research for their collaborations in this project.
\nCatalases are one of the most studied groups of enzymes. The term catalase was first identified by Loew as hydrogen peroxide (H2O2) degrading enzyme in 1901, and the protein has been the focus of study for biochemists and molecular biologists ever since. The overall reaction for catalase can simply be described as the degradation of two molecules of hydrogen peroxide to water and oxygen (reaction 1). This catalytic reaction occurs in two distinct stages, but what each of the stages includes is mainly based on the kind of catalase [1]. The first stage involves oxidation of the heme using first hydrogen peroxide molecule to form an oxyferryl species in which one oxidation equivalent is taken off from the iron and one from the porphyrin ring to make a porphyrin cation radical (reaction 2). In the second stage, this radical intermediate, known as compound I, is reduced by a second hydrogen peroxide to regenerate the resting state enzyme, water and oxygen (reaction 3) [2, 3]. Catalases can also function as peroxidases, in which suitable organic compound is used as an electron donor. During peroxidase reaction, compound I is converted to compound II (reaction 4), which can be oxidized by another hydrogen peroxide to produce the inactive compound III (reaction 5). For NADPH-binding catalases, it has been suggested that enzyme inhibition through the appearance of compound III can be prevented by the NADPH blocking or releasing compound II generation [4, 5, 6].
Catalases have been classified into three groups: monofunctional heme-containing catalases, heme-containing catalase-peroxidases, and manganese-containing catalases [7]. Among them, monofunctional catalases constitute the largest and most extensively studied group of catalases [1, 2]. They all possess two-step mechanism for dismutation of hydrogen peroxide. Members of this largest class of catalases can be biochemically subdivided based on having large (75–84 kDa) subunits with heme
Although monofunctional catalases are described as such due to the prolonged-agreed belief that their only role is hydrogen peroxide removal, this rather limited catalytic role has recently been questioned. Vetrano et al. expressed a novel oxidase activity in the absence of hydrogen peroxide [14]. Later, a catalase from
The study of the bacterial response to oxidative stress has given insights into how catalase synthesis is controlled in different cells. Studies with
The regulatory mechanism of the katE gene, encoding HPII, is quite different and requires a functional katF gene as a positive effector [22]. HPII levels are expressed at high levels when cells enter stationary phase and are unaffected by hydrogen peroxide and/or anaerobiosis [9, 22]. The most important factor for HPII induction seems to be σS, as concluded from studies related with the involvement of additional transcription factors [22, 23].
The prosthetic group of horse liver catalase enzyme was first isolated by Stern in 1935 [24]. This non-covalently bound component was identified as protoheme (also called hematin), consisting of an iron atom and a porphyrin ring.
The heme prosthetic group has been found to be buried inside the protein, approximately 20 Å from the surface in almost all hem-containing catalases whose structures have been dissolved [25, 26, 27, 28]. Despite the similarities in heme-binding pocket, catalases from different sources contain different prosthetic groups [29]. All small subunit size catalases have been shown to include a non-covalently bound iron protoporphyrin IX (heme
Structures of heme
The γ-spirolactone ring and additional hydroxyl group make heme
The residues in a contact with heme in the active center are shown to be different for protoheme and heme d enzymes. Such residues for BLC include Met60, Ser216, Leu298, and Met349, whereas analogous residues for PVC involve Ile41, Val209, Pro291, and Leu342 and for HPII contain Ile114, Ile279, Pro356, and Leu407 [29, 35].
Small subunit size catalases have the ability to bind NADP(H) cofactor which is not essential for the activity of catalase [36], but it is believed to have a role in protecting the enzyme from the formation of catalytically inactive intermediate (cpd II) by promoting its reduction to resting state (Fe3+) during catalytic cycle [37, 38]. According to this hypothesis, large subunit enzymes, whose catalytic cycle lacks compound II formation, do not require to bind NADP(H) [38]. It has also been found that NADP(H) is essential for the dismutation of small peroxides, other than hydrogen peroxide [37]. Instead, large subunit size catalases possess the extra C-terminal domain with a flavodoxin-like topology [29, 30]. Despite this difference, residues defining the NADPH pocket in the bovine liver catalase appear to be well preserved in HPII. Only two residues that interact ionically with NADP(H) in the bovine catalase (Asp212 and His304) differ in HPII (Glu270 and Glu362), but it has been proven that their mutation to the bovine sequence does not promote nucleotide binding [4].
As described previously, catalytic reaction occurs in two steps [1, 2, 3]. The first phase of catalytic cycle involves reaction of ferric enzyme and hydrogen peroxide molecule to generate compound I and water. In the second stage, compound I combines with a second molecule of hydrogen peroxide molecule to regenerate the ferric enzyme, molecular oxygen, and water [2].
Paulos and Kraut firstly proposed the formation of compound I using crystal structure of cytochrome c peroxidase in 1980 [39]. According to this mechanism, proton transfer takes places from hydrogen peroxide to distal imidazole group, and iron-oxygen bond is generated [40]. The studies of water release or rebinding to the coproduct formation site have shown that compound I intermediate might exist in two forms either in a wet form in which a water molecule is present at or near the site of coproduct water formation or dry form where the coproduct water formation site is dry. It is assumed that the presence of water may play a significant role in both substrate selectivity and the variety of redox pathways available in the donor oxidation phase of the catalytic cycles [40, 41].
Compound I intermediate is also perceived in the presence of organic peroxides as substrate, and the reaction rate of compound I production decreases with an increase in the molecular size of the leaving group such as H▬ > CH3▬ > HOCH2▬ > CH3CH2▬ > CH3C(〓O) ▬ > CH3(CH2)2▬ > CH3(CH2)3OOH▬ [42]. At low hydrogen peroxide concentrations and in the presence of suitable organic electron donors, compound I can be reduced by one-electron addition leading to the formation of compound II (a formal Fe4+ state) which can cause enzyme inactivation. In this reaction, the porphyrin accepts one electron, therefore losing its radical character [43, 44].
The proposed catalytic mechanism supports that catalase enzyme is never saturated with its substrate, H2O2, and that turnover of enzyme increases indefinitely as substrate concentration increases [2]. Apparently, catalases have been recognized with a rapid turnover rate and the maximum observed velocities ranging between 54,000 and 833,000 reactions per second [3].
The classical kinetic parameters, Vmax, kcat, and Km, cannot be directly applied to the observed data as catalases do not follow Michaelis-Menten kinetics except at very low substrate concentrations. However, at concentrations below 200 mM, all small subunit size catalases show Michaelis-Menten-like dependence of velocity. At concentrations above 300–500 mM, most small subunit size catalases suffer inactivation. Conversely, large subunit size catalases begin to suffer inhibition above 3 M hydrogen peroxide concentrations [1, 3].
All catalases, whose structure have been dissolved, exhibit highly conserved β-barrel core structure [45]. Their structure is composed of four domains (Figure 2) [26, 30, 46, 47]:
An amino-terminal arm
An anti-parallel eight-stranded β-barrel domain
Wrapping domain
α-helical domain
Schematic drawing of the polypeptide chain and elements of secondary structure in a
The amino-terminal domain is an extended arm and is quite variable in length ranging from 53 residues in
The second domain, referred to as β-barrel domain, is the central feature of catalase. Most of the residues involved in forming the cavity on the distal side of the heme are placed in the first half of the β-barrel. On the other hand, the second half corresponds to the NADP(H)-binding pocket in small subunit catalases. This domain also involves at least six helices situated in two long insertions between β-strands along the polypeptide chain [30, 47].
The wrapping loop is an extended region of almost 110 residues that link the β-barrel and α-helical parts. This region, residues from 366 to 420, does not have any secondary structure except the essential helix (α9) stating the proximal side of heme with tyrosine residue. This part of the polypeptide chain is involved in different interdomain and intersubunit interactions especially with residues from the amino-terminal arm region from another subunit [30, 47].
The α-helical region contains four anti-parallel helices that are close to some of the helices from the β-barrel domain [30, 47].
Unlike BLC, the structures of PVC and HPII present an extra carboxy-terminal domain including roughly 150 residues with a high content of secondary structure elements organized with a “flavodoxin-like” topology [30, 46, 47]. The possible role of this extra domain in PVC remains unknown [30]. In BLC, prior to the flavodoxin-like domain is occupied by an NADP(H) molecule [48].
Although PVC and HPII share common structural similarities, HPII differs in the existence of 60 residues at N-terminal end that increase the contact area between subunits [25].
In all catalases, the heme group is deeply buried in the core structure, and its distance from the nearest part of the molecular surface is about 20 Å [9, 30]. Three residues, tyrosine on the proximal side of the heme (Tyr415 in HPII) and histidine and asparagine on the distal side (His128 and Asn201 in HPII), are believed to be essential for catalysis [30]. The oxygen of phenolic hydroxyl group in tyrosine residue is the proximal ligand of heme iron and is probably deprotonated with negative charge, so that it can lead to the stabilization of iron’s high oxidation states. The imidazole ring of distal histidine is placed almost parallel to the heme at a mean distance of about 3.5 Å above either pyrrole ring III in PMC or pyrrole ring IV in PVC and HPII [9]. The histidine and asparagine residues on the distal side of the heme make the environment strongly hydrophobic [30]. A conserved serine residue (Ser167 in HPII) is also found to be hydrogen bonded to the Nδ of the essential histidine and might facilitate the enzymatic mechanism [46].
Despite possessing the same type of heme in active site, PVC and HPII differ in the presence of covalent bond between tyrosine and histidine residues. HPII contains a novel type of covalent bond joining the Cβ of the essential Tyr415 and the Nδ of His392 but not in PVC [33, 44, 46, 49].
The limited accessibility to heme grouping catalases requires the presence of channels [30]. The heme of the enzyme is connected to the exterior surface by three channels, namely, the main channel, the lateral channel, and the central channel. Among them, the main channel is placed perpendicular to the surface of the heme. The lateral channel approaches horizontal to the heme and the central one heading from the distal side [34, 45].
The main channel is considered to be the primary route for substrate movement to the active site [1, 3]. It is funnel-shaped with 30 Å long in small catalases [30, 48], while in large catalases that channel is replaced by an elongated, constricted, and possibly bifurcated channel that includes the C-terminal domain of adjacent subunit [3, 30].
The conserved residues in the main channel are shown in Figure 3 including the essential histidine, a valine, and an aspartate (His82, Val123, and Asp135 in CATPO) situated 4, 8, and 12 Å from the heme, respectively [17]. The histidine residue is essential for catalysis in HPII, and the side chain of valine residue makes the channel narrower to a diameter of about 3 Å that prevents any molecule larger than H2O and H2O2 from gaining access to the active site. The role of aspartate has not been investigated in any catalase, but the presence of negatively charged side chain has been found to be critical for catalysis [45].
Channels in CATPO of
The lateral or minor channel approaches heme above and below the essential asparagine and emerges in the molecular surface at location corresponding to the NADP(H)-binding pocket in catalases that bind a cofactor (Figure 4) [30, 50]. The function of this channel remains unknown [34]. Molecular dynamics analysis indicates that water can exit the protein through this channel [4].
View of chain A of CATPO complex with 3TR (PDB 5ZZ1, gray) superposed onto human catalase (PDB 1DGH7, blue). CATPO loop 533–537 lies across the top of the NADPH-binding pocket, clashing with the position of the NADPH in the human enzyme [
The main channel is a preferred route for substrate entry, but it might be too long and narrow for the release of reaction products (water and molecular oxygen). As the central channel is mainly hydrophilic and leads to the central cavity that is contiguous to the bulk water, this could be a way out for O2. However, substitutions of amino acid residues extending the major channel in large catalases might allow the exit of oxygen through the main channel. In fact, oxygen preferentially exits through the main channel instead of central one in all catalases having b-type heme in the active site. Thus, the presence of minor channels might be an alternative mechanism for a fast release of products under the condition of high H2O2 stress. These results indicate that O2 can exit the enzyme through different channels although the main exit in large catalases might be through the central channel and in small catalases through the major channel [34, 51].
Many reports on catalase and phenol oxidase enzymes suggest that the activities may flap in some way that catalases exhibit additional oxidase activity and phenol oxidases present further catalase activity. This relationship can be explained by the release of H2O2 due to polyphenol oxidation [52]. Hydrogen peroxide generation by phenol oxidation was also reported by Aoshima and Ayebe [53]. They observed high concentrations of H2O2 in beverages like tea or coffee directly after opening caps as a result of oxygen.
Jolley et al. first developed mushroom tyrosinase with catalase activity in the presence of hydrogen peroxide [54]. Garcia-Molina et al. [55] and Yamazaki et al. [56] also studied this bifunctional behavior of tyrosinase. In addition to this novel tyrosinase, a catalase-like process was found to have one isozyme of catechol oxidase from sweet potatoes (
In literature, the first report on catalase known as a monofunctional enzyme but possessing secondary activity (oxidase) was introduced for mammalian catalase. This enzyme has been reported to present oxidase activity when hydrogen peroxide is absent or levels of H2O2 are low. As mentioned previously, the main function of catalase is the decomposition of hydrogen peroxide into water and oxygen (catalytic activity). Moreover, it is known that catalases can oxidize low molecular weight alcohols in the presence of low concentrations of H2O2 (peroxidatic activity). The catalytic mechanism of catalases is a two-step process in which catalase heme Fe3+ reduces one hydrogen peroxide molecule to water and generates a porphyrin cation radical called compound I, which is then oxidized by a second hydrogen peroxide to give molecular oxygen and water. The peroxidase activity stems from the oxidation of alcohols by compound I through single-electron transfer. Vetrano et al. expressed a novel oxidase activity in the absence of hydrogen peroxide. This oxidase reaction involves the interaction of catalase heme with a strong reducing agent like benzidine (HB) and molecular oxygen leading to the formation of a compound II-like intermediate. The subsequent electron transfer causes substrate oxidation and regeneration of resting enzyme. An incomplete reaction may result in the formation of radical centered intermediates and the production of superoxide [14].
Later, catalase from the thermophilic fungus
There are a great number of reports available describing the structural and biochemical characterization of catalases. However, basic questions related to substrate and product flow remain unanswered, particularly related to the oxidase activity. Therefore researchers have recently focused on the investigation of the region of CATPO that corresponds to the NADPH-binding region of bovine liver catalase (BLC) and the lateral channel. A number of mutations were introduced into this region, and the properties of these mutant variants, including their specific activities and sensitivities to various inhibitors, are interpreted in terms of a role for the lateral channel in CATPO. The structural, mutation, and kinetic evidences suggested that this pocket at the entrance to the lateral channel, captured by NADPH’s nicotinamide moiety in mammalian catalases, should be the site of both oxidase substrate and 3TR binding. The promiscuous nature of CATPO oxidase is clarified by the presence of numerous ordered water molecules which facilitate substrate binding through hydrogen bond formation and can be transferred to accommodate various size and shaped substrates. Peroxide-independent phenolic substrate oxidation is then likely to happen in a similar manner to NADPH oxidation, by electron transfer from the substrate to a high-valent iron-oxo intermediate, apparently arisen through reaction with oxygen [50].
Catalases have been studied for over 100 years, with examples of the enzyme isolated, purified, and characterized from many different organisms. The crystal structures of 16 monofunctional catalases have been solved at high resolution. These structures show that they are tetramers, and each of the four active sites consists of a pentacoordinated-iron protoporphyrin IX prosthetic group with a tyrosinate axial ligand. Some also contain a NADPH cofactor tightly bound at the periphery of each subunit. Recently, it has been found that these enzymes exhibit an oxidase activity in addition to their H2O2 degrading activity. Although they are old enzymes, a peroxide-independent oxidase activity of catalases is new in the literature. Such studies have led to the proposal that this secondary oxidative activity may be a general characteristic of catalases.
The author is grateful to the Department of Biotechnology, Middle East Technical University, Turkey, for providing the necessary facilities during PhD program and many thanks to the Department of Biology, Kocaeli University and TUBİTAK (grant No. 113Z744) for financial support. The author is also grateful to the EU COST Action CM1306 “Movement and Mechanism in Molecular Machines” for STSM support.
The authors declare no conflict of interest.
bovine liver catalase catalase-phenol oxidase compound 3-amino-1,2,4-triazole hydrogen peroxide benzidine hydroperoxidase I hydroperoxidase II L-3,4-dihydroxy-phenylalanine nicotinamide adenine dinucleotide phosphate porphyrin
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These reactions occur through a regular radical chain causing growth of polymer by three steps, namely, initiation, propagation, and termination. To understand ionizing radiation-induced polymerization, the water radiolysis must be taken into consideration. This chapter explores the mechanism of water molecules radiolysis paying especial attention to the basic regularities of solvent radicals’ interaction with the polymer molecules for forming the crosslinked polymer. Water radiolysis is the main engine of the polymerization processes, especially the “free-radical polymerization.” The mechanisms of the free-radical polymerization and crosslinking will be discussed in detail later. Since different polymers respond differently to radiation, it is useful to quantify the response, namely in terms of crosslinking and chain scission. A parameter called the G-value is frequently used for this purpose. It represents the chemical yield of crosslinks, scissions and double bonds, etc. For the crosslinked polymer, the crosslinking density increases with increasing the radiation dose, this is reflected by the swelling degree of the polymer while being immersed in a compatible solvent. If crosslinking predominates, the crosslinking density increases and the extent of swelling decreases. If chain scission predominates, the opposite occurs. A further detailed discussion of these aspects is presented throughout this chapter.",book:{id:"6149",slug:"ionizing-radiation-effects-and-applications",title:"Ionizing Radiation Effects and Applications",fullTitle:"Ionizing Radiation Effects and Applications"},signatures:"Mohamed Mohamady Ghobashy",authors:[{id:"212371",title:"Dr.",name:"Mohamed",middleName:null,surname:"Mohamady Ghobashy",slug:"mohamed-mohamady-ghobashy",fullName:"Mohamed Mohamady Ghobashy"}]},{id:"53504",doi:"10.5772/66925",title:"Applications of Ionizing Radiation in Mutation Breeding",slug:"applications-of-ionizing-radiation-in-mutation-breeding",totalDownloads:3509,totalCrossrefCites:9,totalDimensionsCites:13,abstract:"As a predicted result of increasing population worldwide, improvements in the breeding strategies in agriculture are valued as mandatory. The natural resources are limited, and due to the natural disasters like sudden and severe abiotic stress factors, excessive floods, etc., the production capacities are changed per year. In contrast, the yield potential should be significantly increased to cope with this problem. Despite rich genetic diversity, manipulation of the cultivars through alternative techniques such as mutation breeding becomes important. Radiation is proven as an effective method as a unique method to increase the genetic variability of the species. Gamma radiation is the most preferred physical mutagen by plant breeders. Several mutant varieties have been successfully introduced into commercial production by this method. Combinational use of in vitro tissue culture and mutation breeding methods makes a significant contribution to improve new crops. Large populations and the target mutations can be easily screened and identified by new methods. Marker assisted selection and advanced techniques such as microarray, next generation sequencing methods to detect a specific mutant in a large population will help to the plant breeders to use ionizing radiation efficiently in breeding programs.",book:{id:"5451",slug:"new-insights-on-gamma-rays",title:"New Insights on Gamma Rays",fullTitle:"New Insights on Gamma Rays"},signatures:"Özge Çelik and Çimen Atak",authors:[{id:"147362",title:"Dr.",name:"Özge",middleName:null,surname:"Çelik",slug:"ozge-celik",fullName:"Özge Çelik"},{id:"147364",title:"Prof.",name:"Çimen",middleName:null,surname:"Atak",slug:"cimen-atak",fullName:"Çimen Atak"}]},{id:"32846",doi:"10.5772/36950",title:"Current Importance and Potential Use of Low Doses of Gamma Radiation in Forest Species",slug:"current-importance-and-potential-use-of-low-doses-of-gamma-radiation-in-forest-species",totalDownloads:5301,totalCrossrefCites:2,totalDimensionsCites:13,abstract:null,book:{id:"1590",slug:"gamma-radiation",title:"Gamma Radiation",fullTitle:"Gamma Radiation"},signatures:"L. G. Iglesias-Andreu, P. Octavio-Aguilar and J. Bello-Bello",authors:[{id:"110581",title:"Dr.",name:"Lourdes",middleName:null,surname:"Iglesias-Andreu",slug:"lourdes-iglesias-andreu",fullName:"Lourdes Iglesias-Andreu"}]},{id:"58410",doi:"10.5772/intechopen.72074",title:"Radiation-Induced Degradation of Organic Compounds and Radiation Technologies for Purification of Aqueous Systems",slug:"radiation-induced-degradation-of-organic-compounds-and-radiation-technologies-for-purification-of-aq",totalDownloads:1437,totalCrossrefCites:8,totalDimensionsCites:13,abstract:"Environmental application of radiation technologies is an important part of radiation processing. Radiation treatment of aqueous systems contaminated with organic compounds is a promising method of water and wastewater purification and corresponding technologies are being developed. In this chapter, the following aspects of radiation treatment process are considered: sources of contamination and major contaminants of water and wastewater; primary processes in aqueous systems initiated by ionizing radiation; principal ways of contaminant conversion as consequences of primary processes (complete mineralization of organic compounds, partial decomposition of organic molecules resulted in detoxification, decolorization, disinfection of polluted water, and improvement in biological degradation of contaminant, polymerization of monomers’ contaminants, oxidation-reduction processes, and coagulation of colloids); sources of ionizing radiation; and main equipment applied in radiation technologies of aqueous system purification.",book:{id:"6149",slug:"ionizing-radiation-effects-and-applications",title:"Ionizing Radiation Effects and Applications",fullTitle:"Ionizing Radiation Effects and Applications"},signatures:"Igor E. Makarov and Alexander V. Ponomarev",authors:[{id:"213652",title:"Dr.",name:"Igor",middleName:null,surname:"Makarov",slug:"igor-makarov",fullName:"Igor Makarov"},{id:"213657",title:"Dr.",name:"Alexander",middleName:null,surname:"Ponomarev",slug:"alexander-ponomarev",fullName:"Alexander Ponomarev"}]}],mostDownloadedChaptersLast30Days:[{id:"32842",title:"Sterilization by Gamma Irradiation",slug:"sterilization-by-gamma-irradiation",totalDownloads:74818,totalCrossrefCites:37,totalDimensionsCites:85,abstract:null,book:{id:"1590",slug:"gamma-radiation",title:"Gamma Radiation",fullTitle:"Gamma Radiation"},signatures:"Kátia Aparecida da Silva Aquino",authors:[{id:"102109",title:"Dr.",name:"Katia",middleName:"Aparecida Da S.",surname:"Aquino",slug:"katia-aquino",fullName:"Katia Aquino"}]},{id:"32837",title:"Environmental Gamma-Ray Observation in Deep Sea",slug:"environmental-gamma-ray-observation-in-deep-sea-",totalDownloads:2931,totalCrossrefCites:4,totalDimensionsCites:6,abstract:null,book:{id:"1590",slug:"gamma-radiation",title:"Gamma Radiation",fullTitle:"Gamma Radiation"},signatures:"Hidenori Kumagai, Ryoichi Iwase, Masataka Kinoshita, Hideaki Machiyama, Mutsuo Hattori and Masaharu Okano",authors:[{id:"108174",title:"Dr.",name:"Hidenori",middleName:null,surname:"Kumagai",slug:"hidenori-kumagai",fullName:"Hidenori Kumagai"},{id:"108237",title:"Dr.",name:"Masa",middleName:null,surname:"Kinoshita",slug:"masa-kinoshita",fullName:"Masa Kinoshita"},{id:"137650",title:"Dr.",name:"Ryoichi",middleName:null,surname:"Iwase",slug:"ryoichi-iwase",fullName:"Ryoichi Iwase"},{id:"137656",title:"Dr.",name:"Hideaki",middleName:null,surname:"Machiyama",slug:"hideaki-machiyama",fullName:"Hideaki Machiyama"},{id:"146918",title:"Dr.",name:"Mutsuo",middleName:null,surname:"Hattori",slug:"mutsuo-hattori",fullName:"Mutsuo Hattori"},{id:"146919",title:"Dr.",name:"Masaharu",middleName:null,surname:"Okano",slug:"masaharu-okano",fullName:"Masaharu Okano"}]},{id:"58998",title:"Ionizing Radiation-Induced Polymerization",slug:"ionizing-radiation-induced-polymerization",totalDownloads:1820,totalCrossrefCites:8,totalDimensionsCites:17,abstract:"Ionizing radiation can induce some kinds of reactions, other than polymerization, such as dimerization, oligomerization, curing, and grafting. These reactions occur through a regular radical chain causing growth of polymer by three steps, namely, initiation, propagation, and termination. To understand ionizing radiation-induced polymerization, the water radiolysis must be taken into consideration. This chapter explores the mechanism of water molecules radiolysis paying especial attention to the basic regularities of solvent radicals’ interaction with the polymer molecules for forming the crosslinked polymer. Water radiolysis is the main engine of the polymerization processes, especially the “free-radical polymerization.” The mechanisms of the free-radical polymerization and crosslinking will be discussed in detail later. Since different polymers respond differently to radiation, it is useful to quantify the response, namely in terms of crosslinking and chain scission. A parameter called the G-value is frequently used for this purpose. It represents the chemical yield of crosslinks, scissions and double bonds, etc. For the crosslinked polymer, the crosslinking density increases with increasing the radiation dose, this is reflected by the swelling degree of the polymer while being immersed in a compatible solvent. If crosslinking predominates, the crosslinking density increases and the extent of swelling decreases. If chain scission predominates, the opposite occurs. A further detailed discussion of these aspects is presented throughout this chapter.",book:{id:"6149",slug:"ionizing-radiation-effects-and-applications",title:"Ionizing Radiation Effects and Applications",fullTitle:"Ionizing Radiation Effects and Applications"},signatures:"Mohamed Mohamady Ghobashy",authors:[{id:"212371",title:"Dr.",name:"Mohamed",middleName:null,surname:"Mohamady Ghobashy",slug:"mohamed-mohamady-ghobashy",fullName:"Mohamed Mohamady Ghobashy"}]},{id:"53780",title:"Gamma-Ray Spectrometry and the Investigation of Environmental and Food Samples",slug:"gamma-ray-spectrometry-and-the-investigation-of-environmental-and-food-samples",totalDownloads:2529,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Gamma radiation consists of high‐energy photons and penetrates matter. This is an advantage for the detection of gamma rays, as gamma spectrometry does not need the elimination of the matrix. The disadvantage is the need of shielding to protect against this radiation. Gamma rays are everywhere: in the atmosphere; gamma nuclides are produced by radiation of the sun; in the Earth, the primordial radioactive nuclides thorium and uranium are sources for gamma and other radiation. The technical enrichment and use of radioisotopes led to the unscrupulously use of radioactive material and to the Cold War, with over 900 bomb tests from 1945 to 1990, combined with global fallout over the northern hemisphere. The friendly use of radiation in medicine and for the production of energy at nuclear power plants (NPPs) has caused further expositions with ionising radiation. This chapter describes in a practical manner the instrumentation for the detection of gamma radiation and some results of the use of these techniques in environmental and food investigations.",book:{id:"5451",slug:"new-insights-on-gamma-rays",title:"New Insights on Gamma Rays",fullTitle:"New Insights on Gamma Rays"},signatures:"Markus R. Zehringer",authors:[{id:"311750",title:"Dr.",name:"Markus R.",middleName:null,surname:"Zehringer",slug:"markus-r.-zehringer",fullName:"Markus R. Zehringer"}]},{id:"54118",title:"Gamma Rays from Space",slug:"gamma-rays-from-space",totalDownloads:2089,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"An overview of gamma rays from space is presented. We highlight the most powerful astrophysical explosions, known as gamma-ray bursts. The main features observed in detectors onboard satellites are indicated. In addition, we also highlight a chronological description of the efforts made to observe their high energy counterpart at ground level. Some candidates of the GeV counterpart of gamma-ray bursts, observed by Tupi telescopes, are also presented.",book:{id:"5451",slug:"new-insights-on-gamma-rays",title:"New Insights on Gamma Rays",fullTitle:"New Insights on Gamma Rays"},signatures:"Carlos Navia and Marcel Nogueira de Oliveira",authors:[{id:"189908",title:"Dr.",name:"Carlos",middleName:null,surname:"Navia",slug:"carlos-navia",fullName:"Carlos Navia"},{id:"243084",title:"MSc.",name:"Marcel",middleName:null,surname:"De Oliveira",slug:"marcel-de-oliveira",fullName:"Marcel De Oliveira"}]}],onlineFirstChaptersFilter:{topicId:"227",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82739",title:"Experimental Breeder Reactor II",slug:"experimental-breeder-reactor-ii",totalDownloads:12,totalDimensionsCites:0,doi:"10.5772/intechopen.105800",abstract:"The Experimental Breeder Reactor II (EBR-II) operated from 1964 to 1994. EBR-II was a sodium-cooled fast reactor operating at 69 MWth producing 19 MWe. Rather than using a loop approach for the coolant, EBR-II used a pool arrangement where the reactor core, primary coolant piping, and primary reactor coolant pumps were contained within the pool of sodium. Also contained within the pool was a heat exchanger where primary coolant, which is radioactive, transferred heat to secondary, nonradioactive, sodium. The nuclear power plant included a sodium boiler building where heat from the secondary sodium generated superheated steam, which was delivered to a turbine/generator for electricity production. EBR-II fuel was metallic uranium alloyed with various metals providing significant performance and safety enhancements over oxide fuel. The most significant EBR-II experiments occurred in April 1986. Relying on inherent physical properties of the reactor, two experiments were performed subjecting the reactor to loss of primary coolant flow without reactor SCRAM and loss of the secondary system heat removal without reactor SCRAM. In both experiments, the reactor experienced no damage. This chapter provides a description of the most important design features of EBR-II along with a summary of the landmark reactor safety experiments.",book:{id:"10982",title:"Nuclear Reactors - Spacecraft Propulsion, Research Reactors, and Reactor Analysis Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10982.jpg"},signatures:"Chad L. Pope, Ryan Stewart and Edward Lum"},{id:"82712",title:"Idaho State University AGN-201 Low Power Teaching Reactor: An Overlooked Gem",slug:"idaho-state-university-agn-201-low-power-teaching-reactor-an-overlooked-gem",totalDownloads:10,totalDimensionsCites:0,doi:"10.5772/intechopen.105799",abstract:"A category of reactors called university research and teaching reactors, includes relatively high-power pool-type and low-power solid-core reactors. Many high-power university reactors are largely used for irradiations and isotope production. Their almost constant operation tends to impede student access. A university reactor can be particularly relevant to the university’s mission of preparing well-rounded students who have theoretical knowledge, reinforced by focused laboratory reactor experience. The solid-core Idaho State University Aerojet General Nucleonics (AGN) model 201 reactor operates at such a low power (5 W maximum) that it is not useful for isotope production activities. However, the AGN-201 reactor is well suited for teaching and research activities. The solid-core AGN-201 reactor requires no active cooling system, uses a simple shielding arrangement, and the very low operating power results in trivial burnup providing an operating lifetime exceeding many decades. It is thus worthwhile to examine the Idaho State University AGN-201 nuclear reactor more closely because it offers a wide range of research and teaching capabilities while being widely available to students.",book:{id:"10982",title:"Nuclear Reactors - Spacecraft Propulsion, Research Reactors, and Reactor Analysis Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10982.jpg"},signatures:"Chad L. Pope and William Phoenix"},{id:"81424",title:"Core Reload Analysis Techniques in the Advanced Test Reactor",slug:"core-reload-analysis-techniques-in-the-advanced-test-reactor",totalDownloads:13,totalDimensionsCites:0,doi:"10.5772/intechopen.103896",abstract:"Since becoming a national user facility in 2007, the type of irradiation campaigns the Advanced Test Reactor (ATR) supports has become much more diverse and complex. In prior years, test complexity was limited by the computational ability to analyze the tests’ influence on the fuel. Large volume tests are irradiated in flux traps which are designed to receive excess neutrons from the surrounding fuel elements. Typically, fuel elements drive the test conditions, not vice versa. The computational tool, PDQ, was used for core physics analysis for decades. The PDQ code was adequate so long as the diffusion approximation between test and fuel element remained valid. This paradigm changed with the introduction of the Ki-Jang Research Reactor—Fuel Assembly Irradiation (KJRR-FAI) in 2015. The KJRR-FAI was a prototypic fuel element for the KJRR research reactor project in the Republic of Korea. The KJRR-FAI irradiation presented multiple modeling and simulation challenges for which PDQ was ill suited. To demonstrate that the KJRR-FAI could be irradiated and meet safety requirements, the modern neutron transport codes, HELIOS and MCNP, were extensively verified and validated to replace PDQ. The hybrid 3D/2D methodology devised with these codes made analysis of the ATR with KJRR-FAI possible. The KJRR-FAI was irradiated in 2015-2016.",book:{id:"10982",title:"Nuclear Reactors - Spacecraft Propulsion, Research Reactors, and Reactor Analysis Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10982.jpg"},signatures:"Samuel E. Bays and Joseph W. Nielsen"},{id:"81555",title:"Nuclear Thermal Propulsion",slug:"nuclear-thermal-propulsion",totalDownloads:113,totalDimensionsCites:0,doi:"10.5772/intechopen.103895",abstract:"This chapter will cover the fundamentals of nuclear thermal propulsion systems, covering basic principles of operation and why nuclear is a superior option to chemical rockets for interplanetary travel. It will begin with a historical overview from early efforts in the early 1950s up to current interests, with respect to fuel types, core materials, and ongoing testing efforts. An overview will be provided of reactor types and design elements for reactor concepts or testing systems for nuclear thermal propulsion, followed by a discussion of nuclear thermal design concepts. A section on system design and modeling will be presented to discuss modeling and simulation of driving phenomena: neutronics, materials performance, heat transfer, and structural mechanics, solved in a tightly coupled multiphysics system. Finally, it will show the results of a coupled physics model for a conceptual design with simulation of rapid startup transients needed to maximize hydrogen efficiency.",book:{id:"10982",title:"Nuclear Reactors - Spacecraft Propulsion, Research Reactors, and Reactor Analysis Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10982.jpg"},signatures:"Mark D. DeHart, Sebastian Schunert and Vincent M. Labouré"},{id:"81013",title:"Cyber-Informed Engineering for Nuclear Reactor Digital Instrumentation and Control",slug:"cyber-informed-engineering-for-nuclear-reactor-digital-instrumentation-and-control",totalDownloads:32,totalDimensionsCites:0,doi:"10.5772/intechopen.101807",abstract:"As nuclear reactors transition from analog to digital technology, the benefits of enhanced operational capabilities and improved efficiencies are potentially offset by cyber risks. Cyber-Informed Engineering (CIE) is an approach that can be used by engineers and staff to characterize and reduce new cyber risks in digital instrumentation and control systems. CIE provides guidance that can be applied throughout the entire systems engineering lifecycle, from conceptual design to decommissioning. In addition to outlining the use of CIE in nuclear reactor applications, this chapter provides a brief primer on nuclear reactor instrumentation and control and the associated cyber risks in existing light water reactors as well as the digital technology that will likely be used in future reactor designs and applications.",book:{id:"10982",title:"Nuclear Reactors - Spacecraft Propulsion, Research Reactors, and Reactor Analysis Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10982.jpg"},signatures:"Shannon Eggers and Robert Anderson"},{id:"79671",title:"Fault Detection by Signal Reconstruction in Nuclear Power Plants",slug:"fault-detection-by-signal-reconstruction-in-nuclear-power-plants",totalDownloads:105,totalDimensionsCites:0,doi:"10.5772/intechopen.101276",abstract:"In this work, the recently developed auto associative bilateral kernel regression (AABKR) method for on-line condition monitoring of systems, structures, and components (SSCs) during transient process operation of a nuclear power plant (NPP) is improved. The advancement enhances the capability of reconstructing abnormal signals to the values expected in normal conditions during both transient and steady-state process operations. The modification introduced to the method is based on the adoption of two new approaches using dynamic time warping (DTW) for the identification of the time position index (the position of the nearest vector within the historical data vectors to the current on-line query measurement) used by the weighted-distance algorithm that captures temporal dependences in the data. Applications are provided to a steady-state numerical process and a case study concerning sensor signals collected from a reactor coolant system (RCS) during start-up operation of a NPP. The results demonstrate the effectiveness of the proposed method for fault detection during steady-state and transient operations.",book:{id:"10982",title:"Nuclear Reactors - Spacecraft Propulsion, Research Reactors, and Reactor Analysis Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10982.jpg"},signatures:"Ibrahim Ahmed, Enrico Zio and Gyunyoung Heo"}],onlineFirstChaptersTotal:8},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:33,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"7",title:"Bioinformatics and Medical Informatics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",isOpenForSubmission:!0,editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",slug:"slawomir-wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",biography:"Professor Sławomir Wilczyński, Head of the Chair of Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, Poland. His research interests are focused on modern imaging methods used in medicine and pharmacy, including in particular hyperspectral imaging, dynamic thermovision analysis, high-resolution ultrasound, as well as other techniques such as EPR, NMR and hemispheric directional reflectance. Author of over 100 scientific works, patents and industrial designs. Expert of the Polish National Center for Research and Development, Member of the Investment Committee in the Bridge Alfa NCBiR program, expert of the Polish Ministry of Funds and Regional Policy, Polish Medical Research Agency. 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Kasenga",hash:"91cde4582ead884cb0f355a19b67cd56",volumeInSeries:4,fullTitle:"Malaria",editors:[{id:"86725",title:"Dr.",name:"Fyson",middleName:"Hanania",surname:"Kasenga",slug:"fyson-kasenga",fullName:"Fyson Kasenga",profilePictureURL:"https://mts.intechopen.com/storage/users/86725/images/system/86725.jpg",institutionString:"Malawi Adventist University",institution:{name:"Malawi Adventist University",institutionURL:null,country:{name:"Malawi"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"61c627da05b2ace83056d11357bdf361",volumeInSeries:3,fullTitle:"Current Topics in Neglected Tropical Diseases",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7064",title:"Current Perspectives in Human Papillomavirus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7064.jpg",slug:"current-perspectives-in-human-papillomavirus",publishedDate:"May 2nd 2019",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:302,paginationItems:[{id:"280338",title:"Dr.",name:"Yutaka",middleName:null,surname:"Tsutsumi",slug:"yutaka-tsutsumi",fullName:"Yutaka Tsutsumi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/280338/images/7961_n.jpg",biography:null,institutionString:null,institution:{name:"Fujita Health University",country:{name:"Japan"}}},{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",biography:"Professor Nima Rezaei obtained an MD from Tehran University of Medical Sciences, Iran. He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). 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Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},subseries:[{id:"7",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. 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We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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