Minimal amount of fresh water required for a human living, recommended by the World Health Organization.
\r\n\t
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Prof.Alali has more than 30 publications and he acts as a reviewer in many journals.",coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"209746",title:"Dr.",name:"Saeed",middleName:null,surname:"El-Ashram",slug:"saeed-el-ashram",fullName:"Saeed El-Ashram",profilePictureURL:"https://mts.intechopen.com/storage/users/209746/images/system/209746.jpg",biography:"Dr. Saeed El-Ashram is a professor at Foshan University, China, and Kafrelsheikh University, Egypt, and a research professor at Zhaoqing Dahuanong Biology Medicine Co., Ltd., China. Dr. El-Ashram\\'s research focuses on parasitic diseases. He has more than 100 journal publications to his credit. He is currently an academic editor and reviewer and holds several registered patents. The primary focus of his research is to understand how the animal immune system recognizes and responds to parasitic infections with and/or without a microbial community. Some are the causative agents of significant diseases in humans, such as toxoplasmosis, cryptosporidiosis, alveolar echinococcosis, and fascioliasis. Others are a substantial financial burden to food producers because of the effects these parasites have on domestic animals, for example, coccidiosis and cryptosporidiosis (livestock and poultry).",institutionString:"Foshan University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Foshan University",institutionURL:null,country:{name:"China"}}}],coeditorOne:{id:"73465",title:"Dr.",name:"Guillermo",middleName:null,surname:"Téllez",slug:"guillermo-tellez",fullName:"Guillermo Téllez",profilePictureURL:"https://mts.intechopen.com/storage/users/73465/images/system/73465.jpg",biography:"Guillermo Tellez-Isaias received his DVM and MS in Veterinary Sciences from the National Autonomous University of Mexico (UNAM), and his Ph.D. from Texas A&M University. He worked as a professor at UNAM for sixteen years, eight as head of the Avian Medicine Department, College of Veterinary Medicine. Dr. Tellez was president of the National Poultry Science Association of Mexico and is a member of the Mexican Veterinary Academy and the Mexican National Research System. Currently, he works as a research professor at the Center of Excellence in Poultry Science, University of Arkansas. 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Generally, the unit cost of fresh water production tends to decrease dramatically, as the total scale of production has increased [1]. Therefore, mega-desalination plants have become a popular trend in modern civilization. However, smaller scale desalination is still important for many applications: (i) It could supply water in remote areas where a water supply line is hardly available. (ii) It would be useful for people who cannot afford large investment for a water plant. (iii) It could also be useful as a temporal water source for many people, such as nomads, campers, sailors, or survivors of various disasters.
Thanks to modern technology development, efficient small-scale desalinators became frequently used. Portable reverse osmosis water purifiers powered by electric or fuel engine are commonly used instruments for such purposes. However, such instruments are still too expensive, hard to supply energy source or difficult to maintain for many people in the world, who cannot afford substantial budget, resource or education. For such cases, the desalination method is appropriate technology, which is affordable to the actual users in do-it-yourself (DIY) style and would be a more realistic option than the expensive high-technology solution.
Solar stills are one of the simplest ways of desalination. In solar still, saline water is evaporated by solar heat and condensed to become fresh water. Though it is old, primitive tool, but is still useful for many people. It can be simply made out of low-cost common material, such as plastic sheet or bottles. Therefore, it could be easily installed and operated with do-it-yourself manner. Various solar stills were made and used for long history [2–6]. However, the extreme low productivity has limited its application only to emergency or temporal water source. Considering that the latent heat of water vapour is about 540 cal/g or 2.26 kJ/g and assuming solar energy per unit area as 1 kJ/s m2 (equivalent to 1 sun, which is nominal full sun intensity on bright clear day on earth), we may get about 1.6 kg of distilled water with 1 m2 solar still in an hour. However, even this is only a theoretical maximum value. In reality, only few cups of fresh water could be obtained daily, since there is additional energy loss by vapour leakage or heat dissipation. Though several cups of water should be valuable to save thirsty sufferer, but it might not be enough for sustainable use in everyday life. Of course, we can enlarge the area of solar still to increase water production. However, in many cases, sunny land is also finite resource to be occupied only by solar still.
As shown in Table 1, WHO, the world health organization, recommended 2.5–3 L of drinking water per day per person for survival, including the basic hygiene and cooking purpose, at least 7.5–15 L per day per person is required [7].
Type of need | Quantity | Comments |
---|---|---|
Survival (drinking and food) | 2.5–3 lpd | Depends on climate and individual physiology |
Basic hygiene practices | 2–6 lpd | Depends on social and cultural norms |
Basic cooking needs | 3–6 lpd | Depends on food type, social and cultural norms |
Total | 7.5–15 lpd | Lpd: Litres per day |
Minimal amount of fresh water required for a human living, recommended by the World Health Organization.
Therefore, substantial improvement of productivity should be made on solar still for more practical applications. Multi-effect solar still (MES) was developed to overcome this low productivity problem, by recycling wasted latent heat repeatedly [8–27]. As shown in Figure 1, in MES, multiple layers of evaporating wicks and condensing surface are stacked together [14].
Typical structure of MES. Saline water in upper troughs (114, 124, 134, 144) flows through evaporation wicks (112, 122, 132, 142) and condensed on the condensation surfaces (121, 131, 141) to be collected through the collectors (123, 133, 143).
Saline water flowing through first evaporation wick is partially evaporated, while the condensed saline water is drained out. The water vapour condensed on the first condensation surface would be collected as fresh water. During the condensation process, dissipated latent heat is reused to evaporate saline water running on the second evaporation wick. By repeating this process on multiple layers, the overall water productivity is very much increased. The Tanaka’s group proved both theoretically and experimentally that MES can produce over 10–20 L of fresh water per day with a square metre effective area [8], which is comparable amount to that WHO recommended.
Though MES has more than half century history [2, 3] and performance verification, it is not widely used on practical application yet because of relatively high cost. Metal plates covered with fabric, glass cover, metal or wooden frames and airtight vapour sealants were commonly used materials for traditional MES system. Though they enable rigid and effective MES structure, but still they are relatively expensive and heavy material, which increase overall system cost.
Figure 1 represents typical inner structure of MES. It may include upper saline water trough, vapour condensing plates, wicks where the saline water evaporates, condensed fresh water collecting guide trough. The structures are packed in sun light passing windows and housing.
For higher productivity in MES, intervals between each evaporation wick and condensing surface should be minimized [9, 11]. However, if the distance is too short, the layers could touch each other, so that water droplet on the condensing surface can move to evaporation wick, which causes loss of distilled water. Similarly, if the saline water overflow into condensing surface, serious contamination of produced water could be occurred. Therefore, the wick and condensing surface should be securely isolated by air gap. Despite air gaps between the layers, there is always a chance of contact within layers because of impact, vibration, and gravitational deformation. To minimize such deformation, various approaches were made. Rigid metallic plates were commonly used for stable condensing layer. However, it resulted in increase of cost and system weight. Spacers were placed between the layers [4]. However, water droplet may flow back to wick along the spacer if too much spacers were applied, which may reduce productivity. The layers were placed vertically to avoid gravitational deformation [8–13]. However, it may increase discrepancy between solar incident angle to the system window, which reduces solar energy usage. Reflecting mirrors [12, 24] or tilted window [8, 9, 13, 27] could be placed in front of the vertical layers to maximize solar intensity. However, it may increase the system cost.
To solve this high-cost problem, new MES was designed and tested. To reduce production cost, alternative light-weight and low-cost material was used instead of such expensive materials. Structure of each component was also designed for easier mass production, which may reduce cost. In the next section, the materials and structure of the low-cost MES would be described.
In this work, flexible thin plastic film laminated to black fabric wick was used instead of stainless plate covered with fabric wick [14, 15]. The laminated film is obviously low-cost, light-weight alternative than metallic plates. It could be produced by roll-to-roll process, which is mass production favourable. The laminated film was folded like origami as shown in Figure 2 [14].
The origami structure of wick/condenser layer. Each part of the structure would have role of the evaporation wick (A), condensing surface (B), saline water feeding trough (or pocket) (C), condensed fresh water guiding channel (D) and draining guide which separate the fresh water and waste water (F).
Evaporation wick, condensation surface, upper saline water trough, condensed water guiding channel and concentrated saline water draining guide could be included in this single origami structure. Mixing the fresh and saline water at the end of draining guide could be avoided by folding the edge of the film. This simple structure and process may enable mass production and reduce the production cost.
Flexible wick/condensing layer is vulnerable for deformation which causes mixing back the fresh and saline water. Therefore, specially designed spacers are required for this system. In other hands, tight vapour sealing and thermal insulation are essential for assuring high productivity. In this system, sealing, spacers and inner frames altogether are constructed in one structure, the spacer layer. Its structural features are shown in Figure 3 [14].
Structure of the spacer layers. The vertical spacers are connected to the perimeter frame. Small pictures in circles represent cross section of the spacers (332) which touches the condensing surface (310) laminated to the wick (320).
Vertically elongated spacers are connected to upper and lower parts of the frame. The spacer layer has following roles.
It has a role of internal framework structure standing for each layer of evaporation wick/condensation layer film. The spacer layers and wick/condensing films are alternately stacked as shown in Figure 4. Though the film is too flexible to be stand alone, the film-spacer combined layer is stiff enough to be stand. The stiffness increases by stacking multiple layers.
Alternately stacked wick (coloured black)/condenser (coloured grey) film and the spacer layer (coloured as checkerboard).
The frame holds each vertical spacer in right position and orientation. To avoid a layer’s film touching the next layer film, it is important that each spacer on a layer should be exactly superposed on top of the next layer’s spacer.
Maintaining regular spacer orientation is also necessary. As shown in small circles in Figure 3, the cross sections of the spacers were designed to have sharp angles (less than 90°) towards the contacting plane of the vapour condensing surface. Though most of the condensed water droplets drip down straight on the condensing film, some droplet could stagger out while confronting minor defects on the film surface. Staggering motion may increase chance of the droplet hit the spacer. Once touching the spacer, the droplet would be trapped and flow along the sharp-angled crevice by surface tensional force. As long as it was trapped in the crevice, it would not flow back into the saline water running wick. Therefore, it is important that the spacer to be oriented to maintain the crevice located on condensation surface.
For lab prototype, 5-mm thick polystyrene foam board was hand carved with a knife to make the spacing layer, as shown in Figure 5. While carving, edges of the spacers were shaped to be 60° angle.
Hand carved spacers.
In case of mass production, the foam board could be cut by die press machine (commonly called as Thompson die cutter, a press with pre-shaped knife for cutting soft sheet). While pressing the knife into the foam board, edges of the cutting perimeter are automatically slightly collapsed as round shape, which makes sharp angle at the contact point between the spacer and condensing surface.
The frame also has a role of gasket and heat insulator which minimize heat and vapour leakage from the system. Since it is made out of soft material, foam board, leakage could be avoided by simply pressing the stacks without using additional sealant. It simplifies assembly process and reduces production cost.
Bottom part of the frame (Figure 3) is slightly tilted to the upper part of the frame (Figure 3). The upper part of the frame has role of a cross beam, holding saline water containing trough (or pocket) in Figure 2. Bottom part of the frame has role of condensed water dripping guide. There are multiple grooves on the bottom frame contacting the condensing film. These grooves are for guiding the collected water to be easily flow into the condensed water-guiding channel. Without grove, condensed water could overflow towards the wick, if too much fresh water produced.
Since the evaporation process on each layer repeatedly recycles the latent heat dissipated from the front layer, energy usage of each layer is different. Generally, the layer closely facing sun has more energy for distillation. Therefore, distribution of saline water in proper amount to each layer is critical for high productivity. The Tanaka group did intensive study on how to optimize water distribution, both theoretically and experimentally [8, 11]. They used multiple capillaries with different length to control amount of saline water feed to each layer. Longer capillary reduces flow rate, while short one leads higher flow rate. This is a very useful method, but further simple structure was used in this chapter. A piece of cotton fabric was vertically cut with different width as shown in Figure 6.
Structure of the low-cost water feeding distributer to each wick.
One end of the piece was immersed in saline water feeding container, and other shredded ends were inserted on the saline water pockets (Figure 2) of each layer. Saline water flows along the cotton fabric due to capillary force. Since the flow rate may proportional to the width of the fabric, allocated ratio of saline water to each layer could be simply controlled by controlling shred width of the fabric.
Heat loss should be minimized for higher productivity in MES. Especially for the current structure, it is important to insulate the front and back sides of the layer stacks, since the sides of stacks are partially insulated already by the frame of spacer layer. Thick (comparable to 10 cm) extended polystyrene foam plate or commercially named as “Isopink” could be placed on the back side of the layer stack. It is commonly used as a construction material for building insulation. For the front window, air-gap window, such as 18 mm thickness, triple layer air-gap polycarbonate could be placed (Figure 7). This window material, commercially called Lexan, is frequently used for greenhouse construction. At the outdoor test, described in the next section, no significant degradation was observed, after leaving the prototype exposed to outdoor climate for more than half year. Though no further long-term stability test was made with this system yet, I expect certain level of environmental durability, since both Lexan and Isopink are already market proven as construction material.
Cross section of the triple layer air-gap polycarbonate window (bottom) and extended polystyrene foam board (up).
Commercial polycarbonate windows are well known for toughness and UV resistance. Therefore, it might be stable for long period. If polycarbonate window is not available, stacks of glass plated with air gap, which has even higher UV resistance, could be used. However, extended polystyrene foam board is somewhat vulnerable to UV light. Though core parts of the system are protected from direct UV light, external case could be damaged for long period. For such case, the housing could be covered with other UV-blocking materials, such as paint or clay. The wicks are protected by UV-resistant window. However, long-term exposure under strong sunlight with continuous water dripping may lead black colour fading out. For that case, the front-most layer could be replaced with the inner layer periodically, since the inner layers are more protected from the UV light, and all the layers are designed to be exactly of same shape. Assuming that the system has 10 layers, and the front-most layer should be replaced after every 2 years, one system can be used for 20 years [23]. For this purpose, the system should have simple structure for assemble and disassemble. Window, stack of the layers and insulating back plates could be assembled by using common string or tie through holes, premade on each component. Unskilled users would be able to do the maintenance without special tool.
Earlier MES models were commonly positioned to receive maximum solar energy during the year. With this structure, the evaporation/condensation layer stack was naturally tilted from the gravitational field. However, gravitational deformation of layers could be caused at the MES. It may cause contact of fresh water droplet to the wick or failure of the system.
As the structure proposed in this chapter, such failure would be minimized because of the spacer layers. Therefore, the system could be placed towards sun side with tilted angle (Figure 8).
MES system installed tilted 45°.
Following the structure described in this section, dry weight of the 1 m2 system with 10 layers may not exceed 20 kg, since it has only light-weight material. (Actually, I got 15 kg mock-up system, with the window, the 10-layer stack and insulator layer, as shown in Figure 9.) Therefore, the user could easily carry and install in DIY manner.
One square metre effective area MES prototype with 10 layers, whose weight is 15 kg.
Production cost for the described MES system is estimated in Table 2 [15]. Material cost could be much lower, if we have massive economy of scale. Further cost down could be made, if lower cost alternative materials are available nearby. For example, multi-layer (air gap) polycarbonate window is relatively expensive material. It could be replaced with plane window and transparent air-bubble wrap which are inexpensive packing materials for wrapping parcels. The material and design could be modified reflecting the best condition where the system would be produced and used.
Item | Expected cost | Comment |
---|---|---|
Housing | 50 USD | Window and insulator housing |
Inner parts | 180 USD | Stacks with 10 layers of spacers, wick/condensing film |
Flow controller | 30 USD | Feeding rate controller, hoses and container |
Processing cost | 40 USD | Labour and instrumental cost |
Total | 300 USD | Model for 1 m2 effective area, which supplies about 10 kg/day fresh water |
Estimated production cost of the MES system.
A MES prototype was handmade using the structure described in previous section for testing its practical feasibility.
Black fabric laminated with plastic film was cut and folded to make the evaporation/condensation layer. Five-millimetre thick polystyrene foam board was used to make the spacer layer. It could be either carved out from one large sheet or assembled from small parts of the frames and thin spacers (Figure 10). It may be easier to make the layer by assembling small parts (and also, save the foam board material), if made with hand one by one. However, for mass production, cutting out from one large sheet by die press would be easier.
Hand carved and assembled spacer layer (A) and die pressed spacer layer (B).
The spacer layers were alternately sandwiched with the evaporation/condensation film, while the condensation surface facing the sharp edge of the spacer. Ten identical spacer-film layers were made and stacked. The stack was sandwiched between 1.8-cm triple layer air-gap polycarbonate (Lexan) window and 10 cm polystyrene foam board, by cable tie or box tape. Box tape is useful for short-term usage but may not be a good choice for long-term test, since it would be deteriorated by UV. Common ropes are more recommended. A piece of shred cotton fabric was used for the capillary water distributer. Gutter was placed to collect all the draining fresh water and concentrated waste water in separate beakers (Figure 11).
Collecting fresh water from each layer by a gutter.
The prototype has 0.219 m2 active area (27 cm width and 81 cm height) with 10 multi-effect layers. It was placed in relatively non-shaded place in Seoul, Korea (North 37° 34′, East 126° 58′), 45° tilted from the vertical position, facing south (Figure 12).
Experimental setup of the prototype MES outdoor test.
Ambient and inner temperature was measured by thermocouples. For inner temperature measurement, position between first and second layers as well as position backside of the last layer was chosen. Two water collecting beakers were placed on top of load cells to measure weight of fresh and concentrated water drained. A pyranometer was placed as same tilting angle (45°) as the prototype, for measuring solar irradiation. All the data were automatically collected by computer every minute.
Figures 13–15 show the result on a sunny day (On 7 July 2014, the daily accumulated solar intensity was measured as 19.5 MJ/m2). It shows that it can produce fresh water about 9 kg/L per m2 day or 0.46 kg/MJ. On a partially cloudy day (30 July 2014, the daily accumulated solar intensity was measured as 13.7 MJ/ m2), it was reduced to 5.7 kg/L per m2 day or 0.41 kg/MJ (Figures 16–18).
Flow rate (normalized to unit area, 1m2) of the fresh (red, the lower curve at the range after 15:00 PM) and wasted (black, the upper curve at the range after 15:00 PM) water verses time by the MES, measured on a sunny day, July 7th, at Seoul Korea.
Solar irradiation measured at same day and location in
Temperature of ambient (blue, the lower curve at the range between 12:00 to 16:00 PM), backside of the last layer (red, the middle curve at the range between 12:00 to 16:00 PM) and backside of the first front layer (black, the upper curve at the range between 12:00 to 16:00 PM) measured at same day and location in
Flow rate (normalized to unit area, 1m2) of the fresh (red, the lower curve at the range after 16:00 PM) and wasted (black, the upper curve at the range after 15:00 PM)water verses time by the MES, measured on a partially cloudy day, July 30th, at Seoul, Korea.
Solar irradiation measured at same day and location in
Temperature of ambient (blue, the lower curve at the range between 15:00 to 18:00 PM), backside of the last layer (red, the middle curve at the range between 15:00 to 18:00 PM) and backside of the first front layer (black, the upper curve at the range between 15:00 to 18:00 PM) measured at same day and location in
This is somewhat smaller number than previous result reported from other group, who showed that 10–20 kg/m2 day was obtained [4]. However, considering that the system is not well optimized yet, it would be a good starting point, proving the practical feasibility. There are still many ways that remain to improve productivity. One example is to optimize and control saline water feeding rate. The Tanaka group showed that proper saline water feeding rate is very critical for high productivity [8, 12]. Too much feeding may cause bad productivity, because the saline water would be drained before it gains enough energy for evaporation. Too low feeding rate may cause dry out of the wick, so the system itself could be deteriorated by salt crystal. It was recommended that ratio between fresh water and concentrated water should be around 1:1. As shown in both Figure 13 and Figure 16, this ratio was not controlled well enough yet, especially from around 15:00 O’clock. Better control on water flow may increase productivity. Further optimization on the feeding water distribution towards each layer would also lead higher productivity. Though shred fabric distributer, described in the previous section, was applied on this prototype, there are still room for further optimization of the shred width for each layer.
To avoid salt contamination, saline water in the wick should not flow into condensation layer. Fortunately, in most cases, it is automatically avoided since capillary force in the wick captures the saline water. However, if too much saline water flows into the system abruptly, which could not be kept within the fabric, of course it may overflow into the condensation layer.
To check any trace of salt contamination, simple method could be used [15]. Diluted basic solution, such as aqueous sodium hydroxide solution, could be mixed with the saline water, which would be desalinated by the system. Since even small trace of hydroxide ion increases pH of the solution, it can be easily noticed if the distillates contaminated by salt. Of course, evaporable pH altering material, such as hydrochloric acid, should not be used for such purpose, since it could be evaporated at the wick to change pH of the condensed water.
With good insulation and tight seal, inner temperature of the MES was observed to be more than 70–80°C under sun, even below freezing point ambient temperature. This is high enough temperature for water evaporation. However, it is generally not recommended to use it under freezing climate. Though the temperature inside of MES is high under sun, it may freeze during night, which may damage the system if repeated for a longer period. In addition to that, the drained water could be frozen at the outlet of MES at cold weather. At the winter, I found icicles underneath the prototype, which mixed back the purified and concentrated water.
Most of the other competing, small-scale solar desalination instrument requires relatively high-end technology and expensive facility to produce each component, such as nano-porous membrane for reverse osmosis, photovoltaic modules, vacuum tubes etc. It makes less-developed societies difficult to self-supply the tool by themselves. However, MES prototype introduced in this chapter was handmade with elementary tools and materials, such as hand knife, polystyrene foam board and fabrics laminated on plastic film. In other word, it can be relatively easily prepared and studied with minimum budget. In addition to that, it is also easy to be mass produced, not only in advanced countries but also in less-developed countries. Therefore, MES supplying chain could be easily made at the actual countries, where the low-cost small-scale desalination is necessary, regardless of its industrial level.
Wick/condensation layer could be mass produced by roll-to-roll lamination of fabric on plastic film. Lamination process itself is not a high-tech engineering. It would be affordable to most of the underdeveloped countries. However, if it is still too difficult to be manufactured by local industry, laminated material could be produced in more-developed region and then transported to the local producers who do not have expensive machineries. Since the film is light weight and small volume, it is easy to be transported. By the local maker, the sheet material could be cut, folded and assembled with relatively low-labour cost.
Similar approach could be made to the spacer layers. It could be mass produced with foam board by die-cutting press. Any other type of cutters could be used, if the press is not available. Other raw materials, such as foam insulators and windows, are common material for construction, which would be available on most part of the world. All the materials, processes and structures could be modified by the developers reflecting the industrial condition of each one. Because of this industrial flexibility, MES could be useful self-producible desalination tool for many countries.
Low-cost multi-effect solar still could be mostly useful for supplying fresh water for individuals or family who cannot access to public water work. Residents near salty or contaminated water source, remote island or seashore could use this tool. However, it could be useful for public or national level also, not only limited to the individual level. It could be a part of social infrastructure: for example, it can replace highway divider or fences in desert or bridge over sea. Fresh water supplied by MES could be used to cultivate plants along the road. It can be used for fence/wall around buildings or districts to provide fresh water for planting or for citizens. MES modules would also be made in form of tile or curtain walls of buildings. Similar to that photovoltaics module could be part of external surface of buildings (building integrated photovoltaics: BIPV), MES could be part of building (building integrated desalination: BIDSAL), which can produce fresh water for the residents [15]. MES could also be useful as public stockpile against natural disaster or terrorism, in case of existing water line malfunctioning.
The MES system introduced in this chapter has both aspects of individuality and publicity. The system could be used as personal water supplier. It could be made, operated and maintained personally without assistance of high-tech industry. However, on the other hands, the system could be more easily produced with lower cost and widely implemented, if mass production industry supports. Once mass produced in low cost, it could be a practical solution to the potable water deficiency problem for large part of the world.
Not only the production and application, research and development of the MES has both individual and public aspects. Initially, I started to develop the low-cost MES as a private project. Because of relatively low material cost and simple measuring instrument, it was an executable project for even an individual. Therefore, I expect that developing MES is relatively easily accessible subject to many other researchers in the world, regardless of their financial status or infrastructure. Every future users, producers or developers of MES in the world may be in different condition: climate; social necessity; industrial level and raw material cost. Therefore, they may need to develop their own optimized system, reflecting their own specific status. Meanwhile, they can share the new findings with others, for worldwide collaboration.
The structure and material introduced in this chapter are just an initial example of low-cost MES. There are many steps that remain before implementation. Further optimization and structural improvement should be made. Practical size prototype should be developed. Long-term stability should be proven by outdoor test under actual climate where the product to be used. Mass production process should be established, reflecting the industrial condition of the producers. Supply chain of raw materials should be established. Local or worldwide distribution of the product should be done with proper instruction of operation and maintenance to the final users. These tasks could be done with international collaboration, especially including the groups in the country where the system has to be implemented. Main purpose of writing this chapter is to suggest active collaboration all over the world. Collaboration between private, public or international supported groups would be helpful for MES implementation. I will also be very happy to be part of the collaboration. Furthermore, it would be helpful to mitigate potable water deficiency problem in the world. Beauty of solar still would be that it may quench thirst of anybody, whether he or she is a drinker or a developer.
I appreciate Dr. Park, Chang-Dae in Korea Institute of Machinery and Materials (KIMM), who first introduced MES to me. The subject introduced in this chapter was strongly motivated by his work. I also appreciate Mr. Jin, Byungjin in On-test who helped to equip the measurement system. I appreciate to Korea Water Forum Secretariat (KWFS), since the prize money from 2015 World Water Challenge at 7th World Water Forum was financially helpful on doing this project.
Since it was a privately supported project, I owe many things to my family. My parents-in-law, Mr. Ahn, Jae Chul and Ms. Lee, Young Sook, kindly encouraged me to install the prototype on their rooftop. I was lucky enough to have sunshine test field at the middle of Seoul, where the non-shaded space is rare because of many tall skyscrapers. I developed the origami structure of wick/condensation film while playing origami with my 2-year-old son, Pak, Jongmin I sincerely hope he lives in better future where less people suffer thirst in the world.
Central auditory processing (CAP) refers to the processes involved in the analysis and interpretation of auditory stimuli. It encompasses the perceptual processing of auditory information by the central auditory nervous system and the neurobiological activity underlying it that gives rise to auditory evoked potentials. It is a well-defined and consolidated entity, both from a clinical and research point of view, as well as in terms of its disorders and associated diagnosis and rehabilitation. In this chapter, we describe aspects of CAPD, including its diagnosis through behavioral and electrophysiological testing. We will cover auditory rehabilitation procedures such as auditory training, and monitoring procedures which include the analysis of electrophysiological findings.
Central auditory processing disorder (CAPD) is a deficit in “the perceptual processing of auditory information in the central nervous system (CNS) and the neurobiologic activity that underlies that processing” [1]. CAPD affects the perceptual and neural processes in the CNS which underlie sound localization and lateralization, auditory discrimination of speech and nonspeech signals, auditory performance when there is competing or degraded acoustic information, a variety of auditory temporal processing and patterning abilities, as well as others [2].
CAPD diagnosis can be performed at any age group, from childhood to adulthood. Alterations present in childhood may persist into adolescence and adulthood, may result from an acquired CNS event (traumatic brain injury, cerebrovascular accidents) and as part of the natural aging process. The estimated prevalence of CAPD may vary across age groups. In school age children the prevalence ranges from 2 to 5% [3] as a primary diagnosis. In cases where the CAPD co-runs with other difficulties such as learning disabilities (approximately 43%) and reading disorders (from 25 to 45%) [4] prevalence increases. While in adults, the prevalence increases with age to 17% at 50–54 years and may be greater than 70% after 60 years [5].
Signs and symptoms of CAPD include one or more behavioral characteristics—reading and writing difficulties, speech and language difficulties, difficulty hearing in background noise, difficulties in perceiving prosodic elements of speech as prosody, difficulty in following complex oral instructions, requesting repetitions of oral information, poor musical skills, sound localization difficulties, and others. This list is illustrative, not exhaustive, and it has to be remembered that these behavioral characteristics are not exclusive to CAPD [1, 6].
CAPD often occurs concurrently with other learning or developmental disabilities and is often associated with related cognitive, linguistic, or behavioral disorders. Sharma et al. [7] reported a high degree of comorbidity between APD and specific language and reading disorders. Individuals with autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) often have processing disorders [8], as well as dyslexia [9], and visual processing disorder [10].
The purpose of diagnosing testing is to identify presence of CAPD and delineate its characteristics and nature. Given the heterogeneity of the profiles of individuals who are referred for CAP assessment and their possible comorbidities, several auditory processing tests have been developed as tools for assessing different central auditory processing abilities. When selecting tests, the audiologist must recognize that a symptom may result from many underlying central auditory processing deficits (e.g., temporal processing, localization, spatial release of masking, performance with concurrent/degraded auditory signals), as well as language processing or cognitive problems. For that, diagnostic tests of central auditory function have been shown to be sensitive and specific for identification of CANS disorders.
The diversity of central hearing deficits supports the need for comprehensive test battery to track the various functions of the CANS. There is currently no universally accepted battery of APD tests. Currently, it is recommended that the behavioral assessment battery include non-verbal stimuli (temporal ordering, temporal resolution, and binaural interaction) and verbal stimuli (low redundancy dichotic and monaural listening). The battery should include tests representative several auditory processes as well as temporal processing, binaural separation, binaural integration, auditory closure, auditory discrimination, and sound localization [1].
Accompanying the behavioral assessment there should also be a carefully selected battery of behavioral tests with documented sensitivity and specificity. In a complementary way, there should be detailed observations of the case history and electrophysiological procedures, which together can provide a better understanding of CANS dysfunction [1, 6]. Even though (C)APD involves difficulties in the perceptual processing of auditory information in the central nervous system, electrophysiological auditory potentials reflect the neurobiologic activity that underlies that processing [6].
In individuals whose auditory processing skills are not developing normally, their auditory processing skills can improve with appropriate treatment. The principle underlying this improvement is called neuroplasticity. Neuroplasticity is the result of experience and stimulation and involves reorganization of the cortex and brainstem. Studies show that the central nervous system’s plasticity allows for reorganization and re-mapping following experience (i.e., either cortical or brainstem stimulation), and that this neural modification is reflected in behavioral changes [11, 12]. Plasticity allows the CANS to accommodate and improve central auditory processing skills [13, 14], with continual practice resulting in learning that automatically leads to better listening skills.
Some principles are fundamental and should serve as guidelines for CAPD intervention. First, the intervention must be specific to the deficit, and personalized considering the patient’s difficulties and strengths. The deficits should be clear from the results of the behavioral assessment, and the diagnosis should be given in terms of the original behavioral complaints.
The intervention should also be multidisciplinary, in most cases involving a variety of domains other than audiological, particularly if there are coexisting disorders. Checking whether CAPD is the primary disorder will help in specifying the focus of intervention and assist in prioritizing the different components and the order of their implementation.
While it is necessary to customize interventions for each individual, to maximize treatment effectiveness the treatment should incorporate both bottom-up and top-down approaches [1, 15, 16, 17]. A top-down approach focuses on auditory signal access and acquisition and includes direct auditory remediation strategies such as auditory training, as well as environmental modifications to increase signal clarity and improve the listening environment. Top-down treatments include training in core resources such as language, memory, and cognition along with environmental modifications and educational interventions [1, 16].
Intervention for CAPD should start as soon as possible after confirmation of diagnosis. It is important that the intervention is comprehensive and multidisciplinary, adding issues related to listening, academic and language, in addition to higher order processes such as attention, memory and executive control in auditory tasks, domains that are commonly affected by CAPD.
When planning an effective approach to treating CAPD, three main components should be included: (a) environmental changes, (b) compensatory strategies, and (c) direct intervention—that is, auditory training. All three areas must be addressed in any intervention plan for individuals with CAPD [1, 15, 16], regardless of the co-occurrence with other disorders or the subject’s age group.
In addition to these three components, some guidelines in the area also recommend the use of auxiliary listening systems, such as FM systems, in the process of auditory processing rehabilitation. This is especially true if the diagnostic exam shows impairment in auditory closure skills, figure-background, and selective attention [6].
Environmental modifications aim to improve the individual’s access to auditory information. This will involve increasing signal clarity and facilitating listening and learning in environments such as school, work, or social situations. Including bottom-up and top-down approaches based on acoustic aspects such as the use of assistive technology, environmental management that includes architectural interventions, removal of noise sources and consequently improvement of signal-to-noise ratios, and interventions for teachers and speakers including manner as information is transmitted and learned, highly redundant language aspects and listening and learning environments are highly recommended. The selection of modifications must be done systematically and must be based entirely on the difficulties presented by the individual and hearing deficits and the effectiveness of the implemented modifications must be continuously monitored [2].
Compensatory strategies, also known as core resource training, are designed to address secondary deficits, strengthening higher-order functions, language, cognitive skills, and academic deficits often seen in individuals with CAPD [1, 6, 15]. Through these strategies, the individual with CAPD is encouraged to take responsibility for their own success in the listening and learning processes, encouraged to paraphrase instructions to clarify misunderstandings, and advanced problem-solving techniques are taught. Involving metacognitive (thinking about thinking) and metalinguistic (thinking about language) strategies that aim to provide compensatory methods to minimize deficits in functional listening, monitor your understanding, identify your difficulties, devise alternative solutions, and be an active listener rather than a passive listener [1, 5, 17].
Auditory training as related to CAPD aims to improve the function of the affected auditory process, the goal being to minimize or eliminate the alteration in auditory processing. Auditory training consists of an intensive series of challenging tasks based on the difficulties presented by the patient during the CAPD assessment [19].
Neuroplasticity is a great ally in the auditory training process. The nervous system is plastic and its capacity for reorganization and re-mapping by experience—neuronal modification—is reflected by behavior change [11, 12]. Changes in the neural substrate are facilitated by the presentation of stimuli in an organized, frequent, and intense way that progressively challenges the patient. The level of difficulty is appropriately graded and the stimuli are integrated into everyday activities. To maximize neuroplasticity, active participation of the patient in training is required. The inclusion of immediate feedback is important, as this gives positive reinforcement. Activities should be at or near the limit of the patient’s ability [3].
Auditory training can be done formally or informally. The difference between the approaches is in the degree of control over the presentation of the stimuli and the environment. In formal training, stimuli are presented through an audiometer, allowing precise control of the level of stimulation and the types of stimuli (normally recorded). There needs to be control of intensity, frequency, stimulus duration, and inter-stimulus interval. Informal training is not concerned with stimulus control: stimuli are presented without the use of an audiometer and can be presented in person, without recordings. Informal training is carried out without the fixed “controls” needed for formal auditory training.
For auditory training to be effective, tasks must be presented systematically and graded by difficulty so that they are challenging and motivating without being exhausting. The level of difficulty is adjusted to allow the patient to achieve correct scores of approximately 70% but not less than 30% [18]. Training should be frequent and intense, considering the lengths of the sessions, the number of sessions, the intervals between sessions, and the timeframe over which the training will be performed [3, 5, 18]. To maximize motivation, performance gains, and generalization, the patient’s active participation is necessary, and should be accompanied by immediate feedback and positive reinforcement. Variation of stimuli and tasks are key factors in successful auditory training [3]. The training programs that prompt these structural and functional changes must be done with auditory material different to those used in the diagnostic tests, which must be reserved only for evaluations [18].
Recent studies suggest that auditory training can serve as a valuable intervention tool for individuals with language deficit CAPD, learning difficulties, alterations in spatial processing, and adult subjects using hearing aids [6, 20, 21, 23, 24, 25].
Software programs are increasingly being used as strategies for auditory training. Computer-based auditory training (CBAT) provides age-appropriate strategies and presentations to keep the patient engaged. Some authors who examined children with CAPD [26], learning difficulties [26], and language and reading problems [26] have demonstrated benefits of this type of training for children with CAPD and associated issues.
Electrophysiology is the branch of neuroscience that explores the electrical activity of neurons and makes it possible to investigate how molecular and cellular processes react to a given stimulus. Neuronal communication takes place through electrical and chemical signals [28].
The electrophysiology of hearing involves small electrical changes that can be collected through electrodes placed on different regions of the scalp. The responses are generated by structures located throughout the auditory pathway and their analysis allows us to understand the normal patterns existing in the processing of auditory information [29].
Electrophysiological techniques allow us to assess auditory information processing, giving us more information about the functioning of the central auditory nervous system. These assessment techniques have provided great advances in neuroaudiology—the field that studies the relationship between the ears and the brain [29]. Other researchers see the need for a whole new field of study related to cognitive auditory sciences which is able to provide information about the correlation between hearing and cognition. They emphasize that hearing disorders need to be treated in an interdisciplinary context, one which should include, depending on the case, the following professionals: speech therapist, psychologist, audiologist, and neurologist [3]. In this way, electrophysiological assessments can play an important role both in the process of assessing auditory processing and also in monitoring auditory rehabilitation programs, such as auditory training [30].
Electrophysiological assessment is a way of analyzing the central auditory nervous system both of patients who actively participate in behavioral assessments and in individuals whose responses appear to be unreliable. There is already a consensus that the assessment and monitoring of auditory processing is only complete when there is a combination of behavioral and electrophysiological methods.
Neuroplasticity is the basis of auditory training programs, and it acts on the connections between neurons and the myelination of neurons as a result of performing auditory tasks. The on-going benefits of auditory training programs can be monitored by performing electrophysiological assessments, measuring neurophysiological changes which occur in both the peripheral and central auditory nervous systems. Electrophysiological assessments are therefore a useful and effective tool in monitoring training programs.
Below are the results of some studies that correlated electrophysiology and auditory training. The results come from researchers who are engaged in studying the effects of auditory training through electrophysiology in different clinical populations.
Research on neurophysiological changes resulting from auditory-perceptual learning for adults with normal hearing suggests that, although the auditory system responds to training, there is a substantial degree of variability among individuals in their ability to make use of physiological cues [31]. Training of auditory skills, even in individuals without complaints of alterations in the processing of auditory information, shows that changes take place in cognitive potentials (notably a reduction in latency of the P300 potential) after a program of auditory intervention [32].
Learning results from the process of assimilating written and spoken language, and this process involves acoustic processing, phonemic processing, and linguistic processing. Integrated processing (acoustic, phonemic, and linguistic) must be complemented by the child’s auditory and linguistic experience, which will be decisive for the learning of reading and writing. Researchers have found that the presence of learning difficulties is often associated with hearing deficits in children, and it is possible to monitor certain electrophysiological responses after auditory training. The results have shown an increase in the amplitude and a decrease in the latency of cortical potentials, although no changes were seen in brainstem responses [27]. The frequency following response (FFR) seems to be a very promising instrument to monitor patients with school difficulties, as well as to analyze the effectiveness of treatments, and it can be used as a biological marker of these changes [33, 34].
CAPD is defined as a disorder in one or more auditory skills involving sound localization and lateralization, auditory discrimination and recognition, temporal aspects, resolution, masking, integration, and temporal ordering. Kraus et al. [35] have reported altered responses in the following assessments: (a) brainstem auditory evoked potentials (ABRs) with click stimuli; (b) middle latency auditory evoked potentials (MLAEPs); and (c) N1 and P2 components of the long latency auditory evoked potential (LLAEP). Results have shown that there seems to be an impairment in auditory discrimination that can be observed in electrophysiological tests (mismatch negativity, MLAEP, and N1 and P2 components), as well as alterations in neural synchrony evidenced by alterations in the ABR that can impact temporal coding and the perception of sounds in the presence of noise.
Hearing deprivation, derived from multiple OM episodes in childhood, can compromise the normal development and maturation of the brainstem, as well as other cerebral and cortical structures. Diminished auditory signals can lead to desynchronization in the auditory cortex both for non-verbal and verbal sounds [36, 37]. Changes in auditory evoked potentials provide objective evidence that the auditory system has been modified [38]. One auditory evoked potential that seems to be more sensitive to deprivation from OM effects is the P300 cognitive potential [39]. The use of verbal stimuli when recording long latency auditory evoked potentials also seems to be very effective, providing additional information about auditory information processing [40].
Hearing loss is a highly prevalent disability and, importantly, studies have shown a correlation between hearing loss and cognition. Typically, the use of a hearing aid is associated with an improvement in the speech perception. It has been observed that auditory training programs improve both the processing of auditory information and of cognitive information in individuals with hearing loss, especially in competitive listening environments [41]. Auditory training programs that include training which requires increased memory demand seem to improve speech perception in noise and, in the process, improve neural response time [42]. Electrophysiology can therefore be an extremely useful tool for recording these changes in neural velocity. Mismatch negativity (MMN) can also be used as an electrophysiological measure for monitoring changes resulting from auditory training, especially in the auditory rehabilitation of patients with hearing loss who use a hearing aid or cochlear implant [43].
The multisensory nature of music can have an impact on vocal production because it involves motor, auditory, and vocal mechanisms [44]. Hearing and voice are interrelated, so that the integrity of the auditory system is important for developing vocal behavior and maintaining vocal quality [45]. Individuals who sing in tune seem to have a particular pattern of responses in their FFR, showing lower latencies and stronger amplitudes than in individuals who sing out of tune. This shows that daily, long-term musical training can modify brain structures and improve the quality of auditory information processing [46].
Electrophysiological tests are important objective measures to verify the effectiveness of auditory training. In addition, it is important to emphasize that an electrophysiological evaluation plays an important role in predicting the gains to be expected from auditory training programs. Evaluation makes it possible to gauge whether the auditory training program should be continued, adjustments should be made, or a whole new intervention program begun. Thus, electrophysiological assessment is extremely important: it can indicate whether neural plasticity is possible (through improved synaptic efficiency and increased neural density) or measure the degree of functional plasticity (from behavioral changes brought about by training in auditory skills).
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Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:148,paginationItems:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/165328/images/system/165328.jpg",biography:"Vahid Asadpour, MS, Ph.D., is currently with the Department of Research and Evaluation, Kaiser Permanente Southern California. He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:null},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:"Manufacturing and Technology Integrated Campus – SENAI CIMATEC",institution:null},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. 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He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. 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He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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