Chemicals used at each stage of hide to leather conversion and wastes generated [13].
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5431",leadTitle:null,fullTitle:"Breast Cancer - From Biology to Medicine",title:"Breast Cancer",subtitle:"From Biology to Medicine",reviewType:"peer-reviewed",abstract:"Breast Cancer - From Biology to Medicine thoroughly examines breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer. The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1. In Section 2, the subsequent chapters introduce molecular and cellular biology of breast cancer with some particular signaling pathways, the gene expression, as well as the gene methylation and genomic imprinting, especially the existence of breast cancer stem cells. In Section 3, some new diagnostic methods and updated therapies from surgery, chemotherapy, hormone therapy, immunotherapy, radiotherapy, and some complementary therapies are discussed. This book provides a succinct yet comprehensive overview of breast cancer for advanced students, graduate students, and researchers as well as those working with breast cancer in a clinical setting.",isbn:"978-953-51-3000-0",printIsbn:"978-953-51-2999-8",pdfIsbn:"978-953-51-4882-1",doi:"10.5772/62922",price:159,priceEur:175,priceUsd:205,slug:"breast-cancer-from-biology-to-medicine",numberOfPages:568,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"d90527637742a2483c1d96d5a5f7cc02",bookSignature:"Phuc Van Pham",publishedDate:"April 5th 2017",coverURL:"https://cdn.intechopen.com/books/images_new/5431.jpg",numberOfDownloads:43550,numberOfWosCitations:27,numberOfCrossrefCitations:33,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:57,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:117,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 11th 2016",dateEndSecondStepPublish:"May 2nd 2016",dateEndThirdStepPublish:"July 29th 2016",dateEndFourthStepPublish:"October 27th 2016",dateEndFifthStepPublish:"December 26th 2016",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"28799",title:"Ph.D.",name:"Phuc Van",middleName:"Van",surname:"Pham",slug:"phuc-van-pham",fullName:"Phuc Van Pham",profilePictureURL:"https://mts.intechopen.com/storage/users/28799/images/system/28799.png",biography:"Phuc Van Pham received his Ph.D. in Human Physiology from Vietnam National University, Ho Chi Minh City, Vietnam. He is currently an Associate Professor of Biology at Vietnam National University; Direct of Stem Cell Institute; Director of the Laboratory of Stem Cell Research and Application; and Vice-Director of the Laboratory of Cancer Research. He is a longstanding lecturer and translational scientist at the University, and is a member of several societies and journal editorial boards focused on stem cells as well as cellular therapy.",institutionString:"VNU-HCM University of Science",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"2",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1075",title:"Breast Oncology",slug:"breast-oncology"}],chapters:[{id:"53860",title:"Epidemiology, Pathology, Management and Open Challenges of Breast Cancer in Central Sudan: A Prototypical Limited Resource African Setting",doi:"10.5772/67175",slug:"epidemiology-pathology-management-and-open-challenges-of-breast-cancer-in-central-sudan-a-prototypic",totalDownloads:1999,totalCrossrefCites:3,totalDimensionsCites:5,hasAltmetrics:0,abstract:"Little is known about breast cancer in Sudan. According to the recent data published by the Khartoum Cancer Registry, breast cancer was the most common cancer among Sudanese women. Generally, breast cancer in native African women is characterized by young age at onset, occurrence in multiparous premenopausal patients, advanced stage at diagnosis, large tumor size, high‐grade and triple‐negative phenotype, with correspondingly poor prognosis. In Sudan, it was reported that about 70% of the women diagnosed with breast cancer were younger than 50 years old. We present here data from local and international publications as well as primary information from the National Cancer Institute in Wad Medani (one of the only two cancer hospitals of the country, both located in Central Sudan in Khartoum and Wad Medani). We provide an up‐to‐date situation analysis of breast cancer in Central Sudan as an example for an African reality and the various open challenges of breast cancer in a limited resource setting. A better understanding of breast cancer in black African women is of global relevance, as there is an alarming increase in breast cancer among young black women worldwide, and these patients have the lowest survival rates.",signatures:"Renato Mariani-Costantini, Moawia Mohammed Ali Elhassan,\nGitana Maria Aceto, Ahmed Abdalla Mohamedani and Khalid\nDafaallah Awadelkarim",downloadPdfUrl:"/chapter/pdf-download/53860",previewPdfUrl:"/chapter/pdf-preview/53860",authors:[{id:"34845",title:"Prof.",name:"Renato",surname:"Mariani Costantini",slug:"renato-mariani-costantini",fullName:"Renato Mariani Costantini"},{id:"43821",title:"Dr.",name:"Khalid",surname:"Awadelkarim",slug:"khalid-awadelkarim",fullName:"Khalid Awadelkarim"},{id:"190476",title:"Dr.",name:"Moawia",surname:"Elhassan",slug:"moawia-elhassan",fullName:"Moawia Elhassan"},{id:"190485",title:"Dr.",name:"Gitana",surname:"Aceto",slug:"gitana-aceto",fullName:"Gitana Aceto"},{id:"194585",title:"Prof.",name:"Ahmed Abdalla",surname:"Mohamedani",slug:"ahmed-abdalla-mohamedani",fullName:"Ahmed Abdalla Mohamedani"}],corrections:null},{id:"52969",title:"Histopathological Characteristics: Clinical Course of Breast Cancer Subtypes Depending on the ER(+) (−)/PR(+) (−) Receptor Status",doi:"10.5772/66176",slug:"histopathological-characteristics-clinical-course-of-breast-cancer-subtypes-depending-on-the-er-pr-r",totalDownloads:1871,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Breast cancer patients were divided into separate groups, which were the estrogen receptor (ER)+/progesterone receptor (PR)+ HER2−, the ER or PR+ HER2−, the ER+/PR+ HER2+, the ER or PR+ HER2+, the ER−/PR− HER2−, and the ER−/PR− HER2+ groups. Patients with the ER/PR(+)/HER2− subtype breast cancers show better clinical prognosis compared to the hormone-negative, triple-negative (TN), and HER2+ subtypes. TN, HER2+ tumors in postmenopausal women were of higher grade, showing lymph node and lymphovascular invasion with poor prognosis in all case series. However, the ER+/PR−/HER2+ subgroup had the lowest survival rates in 2- and 5-year follow-ups. Comparison between the ER+PR+HER2+ and ER+PR−HER2− subgroups showed that HER2− status is an indicator of improved prognosis in long-term follow-up. Single hormone receptor (HR)(+) status, particularly HER2(−) cases, was in between the favorable and poor survival subgroups. The ER−, PR−, and HER2+ properties were found to be risk factors for frequent recurrences. In this chapter, breast cancer subtypes are compared with each other. Results from different studies highlight the importance of ER/PR/HER2 receptor variations in the choice of treatment and prognosis of breast cancer.",signatures:"Nilufer Bulut",downloadPdfUrl:"/chapter/pdf-download/52969",previewPdfUrl:"/chapter/pdf-preview/52969",authors:[{id:"189255",title:"Associate Prof.",name:"Nilufer",surname:"Bulut",slug:"nilufer-bulut",fullName:"Nilufer Bulut"}],corrections:null},{id:"54191",title:"Breast Cancer as an Epstein-Barr Virus (EBV)-Associated Malignancy",doi:"10.5772/66988",slug:"breast-cancer-as-an-epstein-barr-virus-ebv-associated-malignancy",totalDownloads:1459,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The Epstein Barr Virus is among the very first oncogenic viruses to be identified as culprits of human malignancies. Its role as an etiologic agent of breast cancer however remains debated despite mounting molecular evidence. In this chapter we address the challenge of multiple molecular etiologies of breast cancer (BC) with emphasis on the Epstein Barr Virus (EBV) as a potential causative agent within a frame work of gene/environment interaction. We also hope to contribute to a critique of the a concept of universal single agent or gene in cancer etiology. In addition to reviewing further reasons of why EBV should be considered a tumor virus, coupling molecular targets at the initiation stage, we examine evidence for the culpability of EBV as oncogenic virus in relation to the genetic and epigenetic events that leads to carcinogenesis of cancer; and the subsequent downstream interaction including genetic and epigenetic modifiers of signaling and molecular function underlying the cancerous phenotype. The TNF family is taken as an example of how the epigenetic reprogramming process, impacts molecular targets and how these combined interplay of molecular events impinges on pathogenesis and malignancy of breast cancer in humans.",signatures:"Ghimja Fessahaye and Muntaser E. Ibrahim",downloadPdfUrl:"/chapter/pdf-download/54191",previewPdfUrl:"/chapter/pdf-preview/54191",authors:[{id:"69817",title:"Prof.",name:"Muntaser",surname:"Ibrahim",slug:"muntaser-ibrahim",fullName:"Muntaser Ibrahim"}],corrections:null},{id:"53856",title:"Early-Stage Progression of Breast Cancer",doi:"10.5772/65633",slug:"early-stage-progression-of-breast-cancer",totalDownloads:1664,totalCrossrefCites:4,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Breast cancer can be defined as a group of diseases with heterogeneous origins, molecular profiles and behaviors characterized by uncontrolled proliferation of cells within the mammary tissue. Around one in eight women in the US will develop breast cancer in their lifetime, making it the second most frequently diagnosed cancer behind skin cancer [1]. In 2015, an estimated 231,840 cases of invasive carcinoma were diagnosed, and over 40,000 deaths were caused by breast cancer which accounts for almost 7% of all cancer mortality each year. In 2015, 60,290 cases of in situ breast cancer were diagnosed, representing over 14% of all new cancer cases among women and men. The steep increase in diagnosis of early‐stage breast cancer over the past 10 years is believed to be a result of more frequent mammography. However, since over half of these in situ lesions will not progress to invasive breast cancer, controversies have arisen about approaches to treatment and prevention of progression of early‐stage in situ breast cancer. Understanding the mechanisms of transition of normal breast to in situ pre‐neoplastic lesions and invasive breast cancer is currently a major focus of breast cancer research with implications for preventive and clinical management of breast cancer. In this review, we give an overview of current knowledge on the molecular and pathological changes that occur during early‐stage progression of breast cancer and describe some of the current models that are used to study this process.",signatures:"William Kietzman, Anna T. Riegel and Virginie Ory",downloadPdfUrl:"/chapter/pdf-download/53856",previewPdfUrl:"/chapter/pdf-preview/53856",authors:[{id:"190578",title:"Prof.",name:"Anna",surname:"Riegel",slug:"anna-riegel",fullName:"Anna Riegel"},{id:"190580",title:"Dr.",name:"Virginie",surname:"Ory",slug:"virginie-ory",fullName:"Virginie Ory"},{id:"190583",title:"MSc.",name:"William",surname:"Kietzman",slug:"william-kietzman",fullName:"William Kietzman"}],corrections:null},{id:"54190",title:"GWAS in Breast Cancer",doi:"10.5772/67223",slug:"gwas-in-breast-cancer",totalDownloads:1966,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Breast cancer is the most diagnosed cancer in women, and the second cause of cancer-related deaths among women worldwide. It is expected that more than 240,000 new cases and 40,450 deaths related to the disease will occur in 2016. It is well known that inherited genetic variants are drivers for breast cancer development. There are many mechanisms through which germline genetic variation affects prognosis, such as BRCA1 and BRCA2 genes, which account for approximately 20% of the increased hereditary risks. Therefore, it is evident that the genetic pathways that underlie cancer development are complex in which networks of multiple alleles confer disease susceptibility and risks. Global analyses through genome-wide association studies (GWAS) have revealed several loci across the genome are associated with the breast cancer. This chapter compiles all breast GWAS released since 2007, year of the first article published in this area, and discuss the future directions of this field. Currently, hundreds of genetic markers are linked to breast cancer, and understanding the underlying mechanisms of these variants might lead to the discover of biomarkers and targets for therapy in patients.",signatures:"Paulo C.M. Lyra‐Junior, Nayara G. Tessarollo, Isabella S. Guimarães,\nTaciane B. Henriques, Diandra Z. dos Santos, Marcele L.M. de Souza,\nVictor Hugo M. Marques, Laura F.R.L. de Oliveira, Krislayne V.\nSiqueira, Ian V. Silva, Leticia B.A. Rangel and Alan T. Branco",downloadPdfUrl:"/chapter/pdf-download/54190",previewPdfUrl:"/chapter/pdf-preview/54190",authors:[{id:"60359",title:"Dr.",name:"Letícia",surname:"Rangel",slug:"leticia-rangel",fullName:"Letícia Rangel"}],corrections:null},{id:"54294",title:"Circulating Tumor Cells in Breast Cancer: A Potential Liquid Biopsy",doi:"10.5772/66439",slug:"circulating-tumor-cells-in-breast-cancer-a-potential-liquid-biopsy",totalDownloads:2e3,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Circulating tumor cells (CTCs) have emerged as a new generation of liquid biomarker that allows for noninvasive longitudinal disease monitoring. CTCs represent a rare cell population in the blood, surrounded by billions of hematopoietic cells. Due to the rarity of CTCs in the blood, the isolation of pure CTCs’ populations has proven to be challenging. However, a number of new technologies have emerged using CTCs cytometric/immunological and physical characteristics. Currently, patients with greater than 5 CTCs have a shorter progression-free survival, as compared with those with less than 5 CTCs per 7.5 ml of whole blood. Although the CTC count itself is an independent prognostic marker, the field is shifting toward understanding metastasis-relevant marker expression on CTCs for the improvement of the prognostic significance of CTCs. This chapter first introduces the principles of CTC isolation and detection methods, then the clinical utility of CTCs for prediction of prognosis and therapy response. Lastly, the heterogeneity of CTCs will be discussed.",signatures:"Mohamed Kamal, Wajeeha Razaq, Macall Leslie, Smita Adhikari and\nTakemi Tanaka",downloadPdfUrl:"/chapter/pdf-download/54294",previewPdfUrl:"/chapter/pdf-preview/54294",authors:[{id:"188855",title:"Dr.",name:"Takemi",surname:"Tanaka",slug:"takemi-tanaka",fullName:"Takemi Tanaka"},{id:"196565",title:"Dr.",name:"Mohamed",surname:"Kamal",slug:"mohamed-kamal",fullName:"Mohamed Kamal"},{id:"196566",title:"Dr.",name:"Wajeeha",surname:"Razaq",slug:"wajeeha-razaq",fullName:"Wajeeha Razaq"},{id:"196568",title:"BSc.",name:"Macall",surname:"Leslie",slug:"macall-leslie",fullName:"Macall Leslie"}],corrections:null},{id:"53849",title:"DNA Hypermethylation in Breast Cancer",doi:"10.5772/66900",slug:"dna-hypermethylation-in-breast-cancer",totalDownloads:1770,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Cancer development is a complex process with multiple steps. Many factors, including radiation, chemicals, viruses, genetic and epigenetic changes, lead to abnormal proliferation of a single cell, which results in the outgrowth of a population of clonal-derived tumour cells. It has established that DNA hypermethylation, an epigenetic mechanism that occurred by the addition of a methyl group at 5′ position of the pyrimidine ring of cytosine residues at CpG islands through the action of DNA methyltransferase enzymes, has been considered as the cause of human tumorigenesis, including breast cancer development. Moreover, DNA hypermethylation holds a promising application as a potential biomarker for the early detection, prognosis and prediction of drug sensitivity in cancer. Therefore, this chapter focuses on the description and exemplification of the DNA hypermethylation changes, particularly, highlight the DNA hypermethylation as a potential biomarker applied in predictive, diagnostic, prognostic and therapeutic monitoring of breast cancer.",signatures:"Le Huyen Ai Thuy, Lao Duc Thuan and Truong Kim Phuong",downloadPdfUrl:"/chapter/pdf-download/53849",previewPdfUrl:"/chapter/pdf-preview/53849",authors:[{id:"188780",title:"Dr.",name:"Huyen Ai Thuy",surname:"Le",slug:"huyen-ai-thuy-le",fullName:"Huyen Ai Thuy Le"},{id:"190443",title:"Ph.D. Student",name:"Thuan Duc",surname:"Lao",slug:"thuan-duc-lao",fullName:"Thuan Duc Lao"},{id:"201479",title:"MSc.",name:"Phuong",surname:"Kim Truong",slug:"phuong-kim-truong",fullName:"Phuong Kim Truong"}],corrections:null},{id:"53690",title:"ErbB2 Receptor in Breast Cancer: Implications in Cancer Cell Migration, Invasion and Resistance to Targeted Therapy",doi:"10.5772/66902",slug:"erbb2-receptor-in-breast-cancer-implications-in-cancer-cell-migration-invasion-and-resistance-to-tar",totalDownloads:1560,totalCrossrefCites:3,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Overexpression of ErbB2 is found in several types of human carcinomas. In breast tumors, ErbB2 overexpression is detected in up to 20% of patients. Breast cancers in with amplification of ErbB2 are characterized by rapid tumor growth, lower survival rate and increased disease progression. The molecular mechanisms underlying the oncogenic action of ErbB2 involve a complex signaling network that tightly regulates malignant cell migration and invasion and hence metastatic potential. Recent efforts have been made to identify gene expression signatures of ErbB2-positive invasive breast cancers that may represent important mediators of ErbB2-induced tumorigenesis and metastatic progression.\nIn this chapter, we will discuss the canonical ErbB2 signaling pathways responsible for tumor growth and dissemination along with newly identified mediators such as adaptor protein p130Cas and miRNAs. From a therapeutic point of view, the treatment with anti-ErbB2 monoclonal antibody trastuzumab has greatly improved the outcomes of patients with ErbB2 aggressive cancer. Nevertheless, de novo and acquired resistance to trastuzumab therapy still represent a major clinical problem. In the second part of the chapter, we will provide an overview of the mechanisms so far implicated in the onset of resistance to targeted therapy and of the new strategies to overcome resistance.",signatures:"Maria del Pilar Camacho-Leal, Marianna Sciortino and Sara Cabodi",downloadPdfUrl:"/chapter/pdf-download/53690",previewPdfUrl:"/chapter/pdf-preview/53690",authors:[{id:"189004",title:"Ph.D.",name:"Maria Del Pilar",surname:"Camacho Leal",slug:"maria-del-pilar-camacho-leal",fullName:"Maria Del Pilar Camacho Leal"}],corrections:null},{id:"52973",title:"Analysis of 10086 Microarray Gene Expression Data Uncovers Genes that Subclassify Breast Cancer Intrinsic Subtypes",doi:"10.5772/66161",slug:"analysis-of-10086-microarray-gene-expression-data-uncovers-genes-that-subclassify-breast-cancer-intr",totalDownloads:1621,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Breast cancer is a complex disease comprising molecularly distinct subtypes. The prognosis and treatment differ between subtypes; thus, it is important to distinguish one subtype from another. In this chapter, we make use of high-throughput microarray dataset to perform breast cancer subtyping of 10086 samples. Aside from the four major subtypes, that is, Basal-like, HER2-enriched, luminal A, and luminal B, we defined a normal-like subtype that has a gene expression profile similar to that found in normal and adjacent normal breast samples. Also, a group of luminal B-like samples with better prognosis was distinguished from the high-risk luminal B breast cancer. We additionally identified 33 surface-protein encoding genes whose gene expression profiles were associated with survival outcomes. We believe these genes are potential therapeutic targets and diagnostic biomarkers for breast cancer.",signatures:"I-Hsuan Lin and Ming-Ta Hsu",downloadPdfUrl:"/chapter/pdf-download/52973",previewPdfUrl:"/chapter/pdf-preview/52973",authors:[{id:"49774",title:"Prof.",name:"Ming-Ta",surname:"Hsu",slug:"ming-ta-hsu",fullName:"Ming-Ta Hsu"},{id:"172713",title:"Dr.",name:"I-Hsuan",surname:"Lin",slug:"i-hsuan-lin",fullName:"I-Hsuan Lin"}],corrections:null},{id:"52901",title:"Jab1/Csn5 Signaling in Breast Cancer",doi:"10.5772/66174",slug:"jab1-csn5-signaling-in-breast-cancer",totalDownloads:1284,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"c-Jun activation domain-binding protein1 (Jab1), also known as a monomer or the fifth component of the constitutive photomorphogenesis 9 signalosome (Csn5) complex, regulates cell proliferation, cell-cycle progression, and apoptosis and affects a series of pathways. Jab1/Csn5 also promotes cell transformation and tumorigenesis, and its overexpression in many tumor types suggests it is involved in cancer progression and closely associated with poor cancer prognosis. Jab1/Csn5 dysregulation contributes to oncogenesis by deactivating several tumor suppressors. Increasing evidence of the role of Jab1/Csn5 overexpression in breast and other cancers has spurred interest in Jab1/Csn5 inhibitors for cancer therapy. In this chapter, we summarize the evidence demonstrating the importance of Jab1/Csn5 expression in breast and other cancers and review recent advances in dissecting the Jab1/Csn5 signaling pathway along with its potential as a therapeutic target for cancer.",signatures:"Yunbao Pan and Francois X. Claret",downloadPdfUrl:"/chapter/pdf-download/52901",previewPdfUrl:"/chapter/pdf-preview/52901",authors:[{id:"108913",title:"Dr.",name:"Francois",surname:"Claret",slug:"francois-claret",fullName:"Francois Claret"},{id:"190726",title:"Dr.",name:"Yunbao",surname:"Pan",slug:"yunbao-pan",fullName:"Yunbao Pan"}],corrections:null},{id:"52920",title:"Splicing Factors in Breast Cancer: Drivers of the Breast Tumor Fate",doi:"10.5772/66162",slug:"splicing-factors-in-breast-cancer-drivers-of-the-breast-tumor-fate",totalDownloads:1563,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Splicing is a critical step in gene expression, responsible for the excision of introns, producing the mature form of mRNA. Also, the possible arrangements of exons enlarge the proteome in 80%, enabling one gene to encode more than one protein isoform, thus increasing proteome. Growing data show deregulation of splicing events in cancer, being breast cancer the most studied. This aberrant pattern of splicing has an important role in breast tumor progression. These alterations are mainly caused by misexpression of some critical alternative splicing factors. The behavior of these splicing factors is implicated with important clinical features, such as chemoresistance, aggressiveness, and also metastases. In this chapter, the role of five splicing factors is discussed in the light of relevant data about in vitro, in vivo, and ex vivo studies to construct a representative scheme of their behavior in breast cancer progression. Although the presented five splicing factors have important role in breast cancer, only three of them (ESRP1, RBFOX2, and SRSF1) have a more prominent role in tumorigenesis and tumor progression. These concepts will elucidate their role in tumorigenesis and a prospective use as biomarkers in breast cancer.",signatures:"Felipe A. C. da Luz, Paula C. Brígido, Alberto S. Moraes, Rogério A.\nAraújo and Marcelo J. B. Silva",downloadPdfUrl:"/chapter/pdf-download/52920",previewPdfUrl:"/chapter/pdf-preview/52920",authors:[{id:"190065",title:"Prof.",name:"Marcelo",surname:"Silva",slug:"marcelo-silva",fullName:"Marcelo Silva"},{id:"190214",title:"MSc.",name:"Felipe",surname:"Da Luz",slug:"felipe-da-luz",fullName:"Felipe Da Luz"},{id:"190215",title:"Prof.",name:"Rogério",surname:"De Araújo",slug:"rogerio-de-araujo",fullName:"Rogério De Araújo"},{id:"190216",title:"Dr.",name:"Alberto",surname:"Moraes",slug:"alberto-moraes",fullName:"Alberto Moraes"}],corrections:null},{id:"53577",title:"The Role of Stem Cells in Breast Cancer",doi:"10.5772/66904",slug:"the-role-of-stem-cells-in-breast-cancer",totalDownloads:1786,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"A significant progress has been made in describing cellular hierarchy and the stem cell niche in the human mammary gland. Mammary stem and progenitor cells exist in two different states: epithelial-like and mesenchymal-like. Several features of the mammary stem cells predispose them to play a critical role in breast cancer initiation, progression and metastasis. Signaling pathways contributing to the self-renewal, such as Wnt, Notch, Hh and BMP, have been shown to be linked with breast cancer stem cells. Furthermore, biomarkers connected with stemness, such as CD44, CD24, EpCAM and ALDH1, have been identified and used to characterize these cells. Additionally, many different miRNA families and microenvironmental factors were shown to regulate a lot of cancer stem cells properties and maintain their stemness. All these findings have started a new era of breast cancer research. In present breast cancer, stem cells have become the targets of breast cancer therapy, although the tests are mainly on the basic stage level. Since the cancer stem cells are able to escape chemotherapy and are resistant to drugs, radiotherapy and apoptotic processes, the therapeutic targeting is mostly concentrated on the disruption of survival signaling pathways and the use of modern technology, like nanotechnology.",signatures:"Joanna Magdalena Zarzynska",downloadPdfUrl:"/chapter/pdf-download/53577",previewPdfUrl:"/chapter/pdf-preview/53577",authors:[{id:"175016",title:"Dr.",name:"Joanna",surname:"Zarzynska",slug:"joanna-zarzynska",fullName:"Joanna Zarzynska"}],corrections:null},{id:"54049",title:"Ion Channels in Breast Cancer: From Signaling to Therapy",doi:"10.5772/66172",slug:"ion-channels-in-breast-cancer-from-signaling-to-therapy",totalDownloads:2007,totalCrossrefCites:3,totalDimensionsCites:6,hasAltmetrics:1,abstract:"Breast cancer consists of an assortment of illness and therapeutic failure is mostly due to the complex and heterogeneous phenotype of the disease. Recently, changes in expression of several ion channels have been associated with malignancy including breast cancers. This suggests that breast cancer cells might gain a selective advantage by controlling ion channel expression/activity and that ion channels can contribute to the hallmarks of cancer. Due to the growing body of research demonstrating that ion channels are key factors in breast cancer biology. In this chapter, we discuss the role of specific ion channels in contributing to hallmarks of breast and whether these ion channels can be used as potential pharmacologic targets for breast cancer.",signatures:"Dowd Jonathan, Hendin Josh, Daniela F. Fukushiro-Lopes, David\nLaczynski and Saverio Gentile",downloadPdfUrl:"/chapter/pdf-download/54049",previewPdfUrl:"/chapter/pdf-preview/54049",authors:[{id:"185692",title:"Prof.",name:"Saverio",surname:"Gentile",slug:"saverio-gentile",fullName:"Saverio Gentile"}],corrections:null},{id:"53531",title:"Modern Radiotherapy Era in Breast Cancer",doi:"10.5772/66906",slug:"modern-radiotherapy-era-in-breast-cancer",totalDownloads:1831,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Radiation therapy (RT) is one of the major treatment modalities that are used in breast cancer treatment, and depending on the chest-wall anatomy, RT fields have to be customized. Techniques used in planning have been evolving since last two decades from two dimensional (2D) to three-dimensional (3D), while intensity modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT) and even proton therapy have been an option in daily approach. In addition, technological hardware and software advances in delivery and planning systems, total treatment duration of breast RT have been shortened in last decades along with recent hypofractionated radiotherapy schemes or emerging partial-breast irradiation protocols. The other attractive approach—accelerated partial breast irradiation (APBI) could be a reasonable option for highly selected subpopulation of early-stage breast cancer patients out of a clinical trial. Long-term follow-up results have emerged heart and coronary sparing with maximum safety and efficacy. The most important advance could be named as cardiac sparing—deep breath-hold approach—in all the modern technique improvement. Although most advanced techniques in management of breast cancer have not been verified to increase survival, we suggest recommending resource stratified advanced in order to provide best technical and clinical care in this long-term survivor candidates.",signatures:"Yasemin Bolukbasi and Ugur Selek",downloadPdfUrl:"/chapter/pdf-download/53531",previewPdfUrl:"/chapter/pdf-preview/53531",authors:[{id:"189528",title:"Dr.",name:"Ugur",surname:"Selek",slug:"ugur-selek",fullName:"Ugur Selek"},{id:"190551",title:"Dr.",name:"Yasemin",surname:"Bolukbasi",slug:"yasemin-bolukbasi",fullName:"Yasemin Bolukbasi"}],corrections:null},{id:"53892",title:"Breast Cancer and Flavonoids as Treatment Strategy",doi:"10.5772/66169",slug:"breast-cancer-and-flavonoids-as-treatment-strategy",totalDownloads:2027,totalCrossrefCites:4,totalDimensionsCites:7,hasAltmetrics:1,abstract:"Breast cancer is the most prevalent cancer type among women. Despite recent progress in early detection and therapeutic strategies, the rate of mortality is increasing. Anti-estrogens or aromatase inhibitors are preferred to treat the women diagnosed with estrogen-receptor (ER) positive tumors. However, breast tumors usually show intra-tumoral heterogeneity with ER-positive and -negative cells. The advanced breast cancer cells lose the estrogen responsiveness and become aggressive by developing new strategies for rapid proliferation such as mutations in cell cycle machinery. New promising drugs are still being investigating against these types of tumors especially to overcome acquired resistance against chemotherapeutic drugs; however, a successful treatment for metastatic tumors is still unclear. Flavonoids, with various pharmacological activities, are plant or fungus secondary metabolites present in human diet. In plants, beside their role in pigmentation, they may also act as messengers, regulators and cell cycle inhibitors. Therefore, they are being tested in ovarian, cervical as well as breast cancer. Due to the positive correlation between flavonoids-rich diet and lower risk of cancer, flavonoids are referred as chemopreventive agents. The current chapter emphasizes the therapeutic potential of flavonoids and their synthetic analogues as anti-cancer agents in breast cancer providing new insights into the molecular mechanisms.",signatures:"Pinar Obakan-Yerlikaya, Elif Damla Arisan, Ajda Coker-Gurkan and\nNarcin Palavan-Unsal",downloadPdfUrl:"/chapter/pdf-download/53892",previewPdfUrl:"/chapter/pdf-preview/53892",authors:[{id:"183217",title:"Dr.",name:"Damla",surname:"Arisan",slug:"damla-arisan",fullName:"Damla Arisan"},{id:"183665",title:"Dr.",name:"Ajda",surname:"Coker-Gurkan",slug:"ajda-coker-gurkan",fullName:"Ajda Coker-Gurkan"},{id:"183666",title:"Prof.",name:"Pinar",surname:"Obakan-Yerlikaya",slug:"pinar-obakan-yerlikaya",fullName:"Pinar Obakan-Yerlikaya"},{id:"183669",title:"Prof.",name:"Narcin",surname:"Palavan-Unsal",slug:"narcin-palavan-unsal",fullName:"Narcin Palavan-Unsal"}],corrections:null},{id:"52931",title:"Translational Challenges and Therapeutic Opportunities in BRCA1-Related Breast Cancer",doi:"10.5772/66168",slug:"translational-challenges-and-therapeutic-opportunities-in-brca1-related-breast-cancer",totalDownloads:1218,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Although significant progress has been made in the management of the hereditary cancer syndrome related to mutations of BRCA1, two fundamental and clinically relevant questions regarding BRCA1-related cancer syndrome remain unresolved: (1) What factors account for the tissue specificity of the BRCA1-related cancer risk? (2) How does a mutation or loss of BRCA1 lead to the basal-like phenotype of breast cancer? This review focuses on recent studies in BRCA1-related pathways that lead to specific characteristics of the hereditary cancer syndrome and discusses the current translational evidence for exploiting these pathways in new therapeutic strategies. Mounting evidence suggests that estrogen signaling and metabolism, oxidative stress, specific secondary mutations, and regulation of specific progenitor cells and transcriptional programs are critical in BRCA1-associated breast cancer. Strategies geared toward estrogen reduction may play a role in treatment and prevention. Therapies aimed at mitigating oxidative stress may be a strategy for risk reduction, while cancer-cell-specific sensitivity to oxidative stress may also be an opportunity for specific targeting. BRCA1-related transcriptional regulation and signaling provide a number of therapeutic targets, including the PI3-AKT and Notch pathways. Thus, significant opportunities exist in translational and clinical research for developing the treatment strategies for the management of BRCA1-related breast cancer.",signatures:"Jeffrey Johnson, William Audeh, Hisashi Tanaka, Farin Amersi,\nArmando E. Giuliano and Xiaojiang Cui",downloadPdfUrl:"/chapter/pdf-download/52931",previewPdfUrl:"/chapter/pdf-preview/52931",authors:[{id:"188836",title:"Dr.",name:"Xiaojiang",surname:"Cui",slug:"xiaojiang-cui",fullName:"Xiaojiang Cui"},{id:"194416",title:"Dr.",name:"Jeffrey",surname:"Johnson",slug:"jeffrey-johnson",fullName:"Jeffrey Johnson"},{id:"194417",title:"Dr.",name:"William",surname:"Audeh",slug:"william-audeh",fullName:"William Audeh"},{id:"194418",title:"Dr.",name:"Hisashi",surname:"Tanaka",slug:"hisashi-tanaka",fullName:"Hisashi Tanaka"},{id:"194419",title:"Dr.",name:"Farin",surname:"Amersi",slug:"farin-amersi",fullName:"Farin Amersi"},{id:"194420",title:"Dr.",name:"Armando",surname:"Giuliano",slug:"armando-giuliano",fullName:"Armando Giuliano"}],corrections:null},{id:"53631",title:"Molecular Fingerprints and Biomarkers of Breast Cancer",doi:"10.5772/66899",slug:"molecular-fingerprints-and-biomarkers-of-breast-cancer",totalDownloads:1659,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Substantial progress has been made over the past three decades in understanding breast cancer (BC) molecular biology, genomics, and targeted therapy. The recent comprehensive molecular and pathological diversity observed in BC patients indicates that BC is not a homogeneous disease; It may be appropriately defined as a myriad of diseases. The explosion of molecular information in the past 10 years has led to a better understanding of the biologic diversity of breast cancers (BCs), and clues to the different etiologic pathways to BC development. It will be useful to study the epigenetics of BC cells and define the mechanisms of both genetic and epigenetic driving alterations beside the mutations. Identifying the oncogenes and tumor suppressor genes is the purpose cancer diagnostics and therapeutics. Oncogenes as well as novel ones involved in the significantly altered regions would enable researchers to identify new causes and molecular pathways that may be targeted at BC treatment. Our main goal is to provide comprehensive understanding of underlying molecular mechanisms and hallmarks of BC, focusing on the identification of fingerprints and novel molecular targets that will greatly improve the cancer predictive, prognostic, and diagnostic biomarkers and, in addition, the possible targets for novel therapies.",signatures:"Hala Fawzy Mohamed Kamel, Hiba Saeed Bagader Al-Amodi and\nHanan Mohamed AbdElmoneim",downloadPdfUrl:"/chapter/pdf-download/53631",previewPdfUrl:"/chapter/pdf-preview/53631",authors:[{id:"179315",title:"Dr.",name:"Hala",surname:"Fawzy Mohamed Kamel",slug:"hala-fawzy-mohamed-kamel",fullName:"Hala Fawzy Mohamed Kamel"},{id:"184928",title:"Dr.",name:"Hiba",surname:"Al-Amodi",slug:"hiba-al-amodi",fullName:"Hiba Al-Amodi"},{id:"190459",title:"Prof.",name:"Hanan",surname:"Mohamed AbdElmoneim",slug:"hanan-mohamed-abdelmoneim",fullName:"Hanan Mohamed AbdElmoneim"}],corrections:null},{id:"53942",title:"Cardiac Toxicity of HER2-Directed Therapy in Women with Breast Cancer: Epidemiology, Etiology, Risk Factors, and Management",doi:"10.5772/66437",slug:"cardiac-toxicity-of-her2-directed-therapy-in-women-with-breast-cancer-epidemiology-etiology-risk-fac",totalDownloads:1518,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The HER2-targeted therapy have profoundly changed the outcomes of women with HER2-positive breast cancers. Trastuzumab and pertuzumab, HER2-targeting monoclonal antibodies, lapatinib and Neratinib, small molecule inhibitors of HER2 and the epidermal growth factor receptor, and ado-trastuzumab emtansine, a HER2-positive directed antibody drug conjugate, are approved for the treatment of HER2-positive breast cancer.",signatures:"Shahid Ahmed, Arooba Talat, Nayyer Iqbal, Mohamed Emara, Duc\nLe, Amir Sami and Jim Xiang",downloadPdfUrl:"/chapter/pdf-download/53942",previewPdfUrl:"/chapter/pdf-preview/53942",authors:[{id:"178507",title:"Dr.",name:"Shahid",surname:"Ahmed",slug:"shahid-ahmed",fullName:"Shahid Ahmed"}],corrections:null},{id:"53499",title:"Aspects of Immediate and Delayed Alloplastic Breast Reconstruction After Mastectomy",doi:"10.5772/66876",slug:"aspects-of-immediate-and-delayed-alloplastic-breast-reconstruction-after-mastectomy",totalDownloads:1388,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Seventy percent of patients with early breast cancer can be treated by breast-conserving surgery, while the remaining 30% are forced to receive mastectomy. Nearly 30% of these patients choose breast reconstruction. In the last decade, new alternative techniques and improved surgical devices have significantly improved techniques for breast reconstruction that especially include immediate or delayed breast reconstruction with silicone implants as an excellent option. In general, implant reconstruction may be single- or two-stage procedures. Single-stage reconstruction is the preferred technique for patients with small breasts and minimal ptosis, while large breasts with ptosis require reduction mastopexy either combined with dermoglandular flap or with titane net for covering the caudal pole of the implant. Thus, excellent cosmetic results can be achieved. Recent studies showed a significant survival benefit for postmastectomy irradiation in nodal-positive patients, so that many candidates for breast reconstruction are irradiated with a higher probability of wound-healing complications after breast reconstruction and increased rates of other complications like capsular fibrosis.",signatures:"Michael Friedrich and Stefan Kraemer",downloadPdfUrl:"/chapter/pdf-download/53499",previewPdfUrl:"/chapter/pdf-preview/53499",authors:[{id:"189408",title:"Prof.",name:"Michael",surname:"Friedrich",slug:"michael-friedrich",fullName:"Michael Friedrich"},{id:"189826",title:"Prof.",name:"Stefan",surname:"Krämer",slug:"stefan-kramer",fullName:"Stefan Krämer"}],corrections:null},{id:"52933",title:"Internal Mammary Sentinel Lymph Node Biopsy",doi:"10.5772/66158",slug:"internal-mammary-sentinel-lymph-node-biopsy",totalDownloads:1363,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The conception of internal mammary sentinel lymph node biopsy (IM‐SLNB) has been added to the 2009 American Joint Committee on Cancer breast cancer staging manual. However, there has still been slight variation in the surgical treatment model owing to the low visualization rate of internal mammary sentinel lymph nodes (IM‐SLN) with the traditional radiotracer injection technique. According to the hypothesis of IM‐SLN, a modified injection technique (periareolar intraparenchymal, high volume, and ultrasound guidance) was established, which could significantly improve the IM‐SLN visualization rate, and make the IM‐SLNB procedure possible in routine practice. IM‐SLNB could provide minimally invasive staging, prognosis, and decision‐making individually, especially for the patients with clinically positive axilla lymph nodes. Moreover, radiotherapy targeting on internal mammary lymph nodes (IMLN) should be tailored and balanced between the potential benefit and toxicity, and radiotherapy guided by IM‐SLNB could achieve this goal. In the era of emphasizing the effective adjuvant therapy, within the changing therapy approach—more systemic treatment, less loco‐regional treatment—oncologist should reconsider the application of regional IMLN therapy.",signatures:"Yong‐Sheng Wang, Peng‐Fei Qiu and Bin‐Bin Cong",downloadPdfUrl:"/chapter/pdf-download/52933",previewPdfUrl:"/chapter/pdf-preview/52933",authors:[{id:"189822",title:"Prof.",name:"Yong-Sheng",surname:"Wang",slug:"yong-sheng-wang",fullName:"Yong-Sheng Wang"},{id:"190524",title:"Dr.",name:"Peng-Fei",surname:"Qiu",slug:"peng-fei-qiu",fullName:"Peng-Fei Qiu"},{id:"190526",title:"Dr.",name:"Bin-Bin",surname:"Cong",slug:"bin-bin-cong",fullName:"Bin-Bin Cong"}],corrections:null},{id:"53532",title:"Nanobiotechnology for Breast Cancer Treatment",doi:"10.5772/66989",slug:"nanobiotechnology-for-breast-cancer-treatment",totalDownloads:2766,totalCrossrefCites:7,totalDimensionsCites:11,hasAltmetrics:0,abstract:"Despite many technological breakthroughs, even the best breast cancer treatments available today are not 100% effective. Chemotherapy has improved, but many drugs still do not reach the tumor site at effective doses and are often associated with high systemic toxicity and poor pharmacokinetics. Moreover, for many malignancies, diagnosis is obtainable only in metastatic stages of development, reducing the overall effectiveness of treatment. The choice of available treatments depends on tumor characteristics such as biomarkers, tumor size, metastatic disease, ligands, and antigen or endocrine receptor expression. Combined with surgical resection, chemotherapy and radiation remain the first line of treatment for patients with cancer. Even with these treatments, however, cancer continues to have high fatality rates and current therapeutic modalities have yet to significantly improve the often dismal prognosis of this disease. Nanotechnology is a highly focused approach, which may provide more effective and less toxic treatment when compared to chemotherapy. This area of research has emerged as cancer treatment in the form of new drugs and has reached promising results in preclinical and clinical trials proving its value as a potential tumor therapy.",signatures:"Márcia Rocha, Natalia Chaves and Sônia Báo",downloadPdfUrl:"/chapter/pdf-download/53532",previewPdfUrl:"/chapter/pdf-preview/53532",authors:[{id:"147895",title:"Dr.",name:"Sônia Nair",surname:"Báo",slug:"sonia-nair-bao",fullName:"Sônia Nair Báo"},{id:"190527",title:"MSc.",name:"Natalia",surname:"Chaves",slug:"natalia-chaves",fullName:"Natalia Chaves"},{id:"190529",title:"MSc.",name:"Marcia",surname:"Oliveira Da Rocha",slug:"marcia-oliveira-da-rocha",fullName:"Marcia Oliveira Da Rocha"}],corrections:null},{id:"53910",title:"Immunotherapeutic and Preventive Role of Purified Extract Rich in Beta-Glucans Derived from D-Fraction of Grifola frondosa Mushroom in Experimental Mice Biomodel of Mammary Carcinogenesis",doi:"10.5772/66890",slug:"immunotherapeutic-and-preventive-role-of-purified-extract-rich-in-beta-glucans-derived-from-d-fracti",totalDownloads:1363,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"The overall vision of the modern science needs to change to a revalorization of the natural compounds and their beneficial effects on human diseases, such as cancer. Medicinal mushrooms have been used since thousands of years due to its healing properties. Maitake (Grifola frondosa) is presented as one of the most interesting medicinal mushrooms that have been studied. Until now, Maitake D-Fraction may have anticarcinogenic activity, preventing oncogenesis and metastasis in certain tumor types. However, the exact molecular mechanism by which D-Fraction acts are yet unknown. The results shown in this chapter suggest that Maitake D-Fraction Pro4X, administered intraperitoneally, prevents significantly the development of mammary tumorigenesis, increases survival, and reduces the process of angiogenesis in BALBc mice. Although yet to determine the active component of the extract and the molecular mechanism by which it operates in the breast carcinogenesis process. The socioeconomic impact of this research project could be important, considering that in Argentina similar studies using natural compounds derived from medicinal mushrooms for cancer therapy have not yet been performed. The beneficial effects of Maitake, if proven, could be useful for the treatment of cancer patients who are undergoing chemotherapy or radiation or for breast cancer prevention in high-risk population.",signatures:"Aguilera Braico, Diego Máximo and Gabriela Andrea Balogh",downloadPdfUrl:"/chapter/pdf-download/53910",previewPdfUrl:"/chapter/pdf-preview/53910",authors:[{id:"190412",title:"MSc.",name:"Diego",surname:"Aguilera Braico",slug:"diego-aguilera-braico",fullName:"Diego Aguilera Braico"},{id:"190413",title:"Dr.",name:"Gabriela",surname:"Balogh",slug:"gabriela-balogh",fullName:"Gabriela Balogh"}],corrections:null},{id:"53993",title:"Breast Cancer: From Transcriptional Control to Clinical Outcome",doi:"10.5772/66888",slug:"breast-cancer-from-transcriptional-control-to-clinical-outcome",totalDownloads:1579,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Breast cancer is the most common malignancy in women worldwide. The risk of breast cancer in women increases with age, and this is partly attributable to the accumulation of genetic lesions. Growing evidence demonstrates the role played by epigenetic modifiers and the tumor microenvironment in contributing to the increased risk of breast cancer. This chapter provides a comprehensive overview of the epigenetic regulatory signatures that impact the well-studied signaling pathways in breast tissues. Additionally, we will also delve into the therapeutic and diagnostic potential of noncoding RNAs in breast cancer.",signatures:"Sudhakar Jha, Deepa Rajagopalan, Shainan Hora and Shweta\nPradip Jadhav",downloadPdfUrl:"/chapter/pdf-download/53993",previewPdfUrl:"/chapter/pdf-preview/53993",authors:[{id:"190426",title:"Dr.",name:"Sudhakar",surname:"Jha",slug:"sudhakar-jha",fullName:"Sudhakar Jha"}],corrections:null},{id:"54012",title:"Immune Regulation in Breast Cancer Metastasis and Immunotherapy",doi:"10.5772/66991",slug:"immune-regulation-in-breast-cancer-metastasis-and-immunotherapy",totalDownloads:1411,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"There are significant alterations in the tumor surrounding stromal cells in addition to the cancer cells in tumor microenvironment. Tumor cells can metastasize by acquiring the ability to escape immune control and surveillance. A decline in the ability of the immune cells to recognize and kill the tumor leads to tumor relapse or metastasis after primary treatment. Comprehensive review in this chapter will be conducted to further investigate into the mechanism of immune evasion in metastatic tumor microenvironment. The immune cells, stromal cells, extracellular matrix protein/component, and their interaction will be reviewed and summarized. Breast cancer has not been previously viewed as a particularly immunogenic type of tumor. Nevertheless, immune parameters have been increasingly studied in breast cancer, and accumulating data show that they are relevant for the development and progression of this tumor type. Consequently, immunotherapies of breast cancer are now tested in different clinical trials. The prospect of immunotherapy in metastatic breast cancer will be introduced. The importance of host‐targeted modulation/therapy will be increased in addition to cancer‐targeted strategies. We have to better define subpopulations of breast cancer patients to optimize the immunological way to overcome the cancer metastasis.",signatures:"Ming-Shen Dai",downloadPdfUrl:"/chapter/pdf-download/54012",previewPdfUrl:"/chapter/pdf-preview/54012",authors:[{id:"190480",title:"Dr.",name:"Ming-Shen",surname:"Dai",slug:"ming-shen-dai",fullName:"Ming-Shen Dai"}],corrections:null},{id:"53440",title:"Felt Needs for Rehabilitation After Breast Cancer Treatment in Mexico",doi:"10.5772/66436",slug:"felt-needs-for-rehabilitation-after-breast-cancer-treatment-in-mexico",totalDownloads:1397,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Breast cancer (BC) is the most frequent type of malignancy among women worldwide and the most common cause of mortality, particularly in low and middle‐income countries. As detection and treatment have improved, a larger number of surviving women need adequate rehabilitation after treatment. However, awareness among affected patients remains low. Thus, the aim of this study was to explore the needs and expectations concerning rehabilitation among Mexican women after breast surgery. An ethnographic approach was used. Eight focus groups were conducted in the north‐central state of San Luis Potosí, Mexico, in 2014, in which women under treatment and survivors participated. Results showed that women had insufficient and misleading information concerning the need for rehabilitation from health care authorities. Women seemed to focus more on survival than on quality of life after treatment even though impairments limiting their daily life activities caused frustration and feelings of uselessness. In conclusion, many women perceived the need for rehabilitation, but information was largely lacking. Public health services fail to provide rehabilitation services, which are now partially covered by private organizations. Treatment for breast cancer should be accompanied by rehabilitation. Awareness, availability and access to physiotherapy services need to be put in place.",signatures:"Viveka Hammelin, Luz María Tejada‐Tayabas, Dulce María Galarza‐\nTejada and Joel Monárrez‐Espino",downloadPdfUrl:"/chapter/pdf-download/53440",previewPdfUrl:"/chapter/pdf-preview/53440",authors:[{id:"190554",title:"Associate Prof.",name:"Joel",surname:"Monárrez-Espino",slug:"joel-monarrez-espino",fullName:"Joel Monárrez-Espino"}],corrections:null},{id:"53341",title:"Naringenin Inhibits Proliferation and Survival of Tamoxifen‐ Resistant Breast Cancer Cells",doi:"10.5772/66698",slug:"naringenin-inhibits-proliferation-and-survival-of-tamoxifen-resistant-breast-cancer-cells",totalDownloads:1491,totalCrossrefCites:4,totalDimensionsCites:7,hasAltmetrics:0,abstract:"The majority of breast cancers are estrogen receptor positive (ER+) and utilize estrogen to promote cell proliferation. Thus, the ER has been the target of many therapies. While this strategy has been successful, the long‐term use of antiestrogen therapies, such as tamoxifen (Tam), frequently results in Tam resistance (Tam‐R). Tam‐R cells may proliferate due to the activation of the phosphatidylinositol‐3 kinase (PI3K) and the mitogen‐activated protein kinase (MAPK) pathways. Targeting these proliferation and survival pathways after the development of resistance is critical for the treatment of drug‐resistant cancers. We have identified the flavanone Naringenin (Nar) as an inhibitor of both the PI3K and MAPK pathways. Here, we show that Nar impairs cell proliferation and induces apoptosis of Tam‐R MCF‐7 breast cancer cells. We also demonstrate that Nar treatment reduced the levels of both ERK and AKT in Tam‐R cells. Furthermore, Nar treatment localized ERα to a perinuclear region in Tam‐R cells. Nar may function by inhibiting both the PI3K and MAPK pathways as well as localizing ERα to the cytoplasm to impair cell proliferation of Tam‐R MCF‐7 cells. These studies provide insight into the molecular mechanisms involved in cell proliferation of Tam‐R breast cancer cells.",signatures:"Joseph Ramos, Talia Hatkevich, Lauren Eanes, Idalys Santos‐Sanchez\nand Yashomati M. Patel",downloadPdfUrl:"/chapter/pdf-download/53341",previewPdfUrl:"/chapter/pdf-preview/53341",authors:[{id:"192549",title:"Dr.",name:"Yashomati",surname:"Patel",slug:"yashomati-patel",fullName:"Yashomati Patel"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"5770",title:"Mesenchymal Stem Cells",subtitle:"Isolation, Characterization and Applications",isOpenForSubmission:!1,hash:"8d2f6e69167ad835f02cf8848065c202",slug:"mesenchymal-stem-cells-isolation-characterization-and-applications",bookSignature:"Phuc Van Pham",coverURL:"https://cdn.intechopen.com/books/images_new/5770.jpg",editedByType:"Edited by",editors:[{id:"28799",title:"Ph.D.",name:"Phuc Van",surname:"Pham",slug:"phuc-van-pham",fullName:"Phuc Van Pham"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"329",title:"Breast Cancer",subtitle:"Carcinogenesis, Cell Growth and Signalling Pathways",isOpenForSubmission:!1,hash:"ebf7902b7672e9142e56de2289bcaa5a",slug:"breast-cancer-carcinogenesis-cell-growth-and-signalling-pathways",bookSignature:"Mehmet Gunduz and Esra Gunduz",coverURL:"https://cdn.intechopen.com/books/images_new/329.jpg",editedByType:"Edited by",editors:[{id:"46056",title:"Prof.",name:"Mehmet",surname:"Gunduz",slug:"mehmet-gunduz",fullName:"Mehmet Gunduz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1278",title:"Breast Cancer",subtitle:"Focusing Tumor Microenvironment, Stem cells and Metastasis",isOpenForSubmission:!1,hash:"bd2df7c338f309db645c7c183571f6a8",slug:"breast-cancer-focusing-tumor-microenvironment-stem-cells-and-metastasis",bookSignature:"Mehmet Gunduz and Esra Gunduz",coverURL:"https://cdn.intechopen.com/books/images_new/1278.jpg",editedByType:"Edited by",editors:[{id:"46056",title:"Prof.",name:"Mehmet",surname:"Gunduz",slug:"mehmet-gunduz",fullName:"Mehmet Gunduz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1277",title:"Breast Cancer",subtitle:"Current and Alternative Therapeutic Modalities",isOpenForSubmission:!1,hash:"9c0bc3b171254b2a3f7d52bee5c559aa",slug:"breast-cancer-current-and-alternative-therapeutic-modalities",bookSignature:"Esra Gunduz and Mehmet Gunduz",coverURL:"https://cdn.intechopen.com/books/images_new/1277.jpg",editedByType:"Edited by",editors:[{id:"61074",title:"Dr.",name:"Esra",surname:"Gunduz",slug:"esra-gunduz",fullName:"Esra Gunduz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2883",title:"Oncogene and Cancer",subtitle:"From Bench to Clinic",isOpenForSubmission:!1,hash:"ba08b50f799acf44d8d2f0f0c6c2e768",slug:"oncogene-and-cancer-from-bench-to-clinic",bookSignature:"Yahwardiah Siregar",coverURL:"https://cdn.intechopen.com/books/images_new/2883.jpg",editedByType:"Edited by",editors:[{id:"137622",title:"Dr.",name:"Yahwardiah",surname:"Siregar",slug:"yahwardiah-siregar",fullName:"Yahwardiah Siregar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1276",title:"Targeting New Pathways and Cell Death in Breast Cancer",subtitle:null,isOpenForSubmission:!1,hash:"e1541edf35e439e637938657d6ac482b",slug:"targeting-new-pathways-and-cell-death-in-breast-cancer",bookSignature:"Rebecca L. Aft",coverURL:"https://cdn.intechopen.com/books/images_new/1276.jpg",editedByType:"Edited by",editors:[{id:"45492",title:"Dr.",name:"Rebecca",surname:"Aft",slug:"rebecca-aft",fullName:"Rebecca Aft"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4549",title:"A Concise Review of Molecular Pathology of Breast Cancer",subtitle:null,isOpenForSubmission:!1,hash:"defcba71c9acb69a0f9c99264c4856c5",slug:"a-concise-review-of-molecular-pathology-of-breast-cancer",bookSignature:"Mehmet Gunduz",coverURL:"https://cdn.intechopen.com/books/images_new/4549.jpg",editedByType:"Edited by",editors:[{id:"38384",title:"Prof.",name:"Mehmet",surname:"Gunduz",slug:"mehmet-gunduz",fullName:"Mehmet Gunduz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1310",title:"Topics in Cancer Survivorship",subtitle:null,isOpenForSubmission:!1,hash:"6ea3485c7d116f29327e36b78c5e9e6f",slug:"topics-in-cancer-survivorship",bookSignature:"Ravinder Mohan",coverURL:"https://cdn.intechopen.com/books/images_new/1310.jpg",editedByType:"Edited by",editors:[{id:"58197",title:"Prof.",name:"Ravinder",surname:"Mohan",slug:"ravinder-mohan",fullName:"Ravinder Mohan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1279",title:"Breast Cancer",subtitle:"Recent Advances in Biology, Imaging and Therapeutics",isOpenForSubmission:!1,hash:"eb213b69670bbf5c4c6ab643bb13c4d4",slug:"breast-cancer-recent-advances-in-biology-imaging-and-therapeutics",bookSignature:"Susan J. Done",coverURL:"https://cdn.intechopen.com/books/images_new/1279.jpg",editedByType:"Edited by",editors:[{id:"51859",title:"Dr.",name:"Susan",surname:"Done",slug:"susan-done",fullName:"Susan Done"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6633",title:"Breast Cancer and Surgery",subtitle:null,isOpenForSubmission:!1,hash:"05f2f1a893b64cb77385aed5dd184fa1",slug:"breast-cancer-and-surgery",bookSignature:"Nilufer Bulut",coverURL:"https://cdn.intechopen.com/books/images_new/6633.jpg",editedByType:"Edited by",editors:[{id:"189255",title:"Associate Prof.",name:"Nilufer",surname:"Bulut",slug:"nilufer-bulut",fullName:"Nilufer Bulut"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"69566",slug:"corrigendum-to-a-brief-overview-of-ophthalmic-ultrasound-imaging",title:"Corrigendum to: A Brief Overview of Ophthalmic Ultrasound Imaging",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/69566.pdf",downloadPdfUrl:"/chapter/pdf-download/69566",previewPdfUrl:"/chapter/pdf-preview/69566",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/69566",risUrl:"/chapter/ris/69566",chapter:{id:"65491",slug:"a-brief-overview-of-ophthalmic-ultrasound-imaging",signatures:"David B. Rosen, Mandi D. Conway, Charles P. Ingram, Robin D. Ross and Leonardo G. Montilla",dateSubmitted:"November 6th 2018",dateReviewed:"December 12th 2018",datePrePublished:"February 5th 2019",datePublished:"September 4th 2019",book:{id:"8633",title:"Novel Diagnostic Methods in Ophthalmology",subtitle:null,fullTitle:"Novel Diagnostic Methods in Ophthalmology",slug:"novel-diagnostic-methods-in-ophthalmology",publishedDate:"September 4th 2019",bookSignature:"Anna Nowinska",coverURL:"https://cdn.intechopen.com/books/images_new/8633.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"261466",title:"Dr.",name:"Anna",middleName:"Karolina",surname:"Nowińska",slug:"anna-nowinska",fullName:"Anna Nowińska"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"274007",title:"Prof.",name:"Mandi D.",middleName:null,surname:"Conway",fullName:"Mandi D. Conway",slug:"mandi-d.-conway",email:"mconway1@yahoo.com",position:null,institution:null},{id:"283754",title:"Dr.",name:"Robin",middleName:"Demi",surname:"Ross",fullName:"Robin Ross",slug:"robin-ross",email:"robindross@email.arizona.edu",position:null,institution:null},{id:"284051",title:"BSc.",name:"David",middleName:null,surname:"Rosen",fullName:"David Rosen",slug:"david-rosen",email:"davidrosen@email.arizona.edu",position:null,institution:null},{id:"284377",title:"BSc.",name:"Leonardo",middleName:null,surname:"Montilla",fullName:"Leonardo Montilla",slug:"leonardo-montilla",email:"funrunner13@gmail.com",position:null,institution:null},{id:"284378",title:"MSc.",name:"Charles",middleName:null,surname:"Ingram",fullName:"Charles Ingram",slug:"charles-ingram",email:"cingram@optics.arizona.edu",position:null,institution:null}]}},chapter:{id:"65491",slug:"a-brief-overview-of-ophthalmic-ultrasound-imaging",signatures:"David B. Rosen, Mandi D. Conway, Charles P. Ingram, Robin D. Ross and Leonardo G. Montilla",dateSubmitted:"November 6th 2018",dateReviewed:"December 12th 2018",datePrePublished:"February 5th 2019",datePublished:"September 4th 2019",book:{id:"8633",title:"Novel Diagnostic Methods in Ophthalmology",subtitle:null,fullTitle:"Novel Diagnostic Methods in Ophthalmology",slug:"novel-diagnostic-methods-in-ophthalmology",publishedDate:"September 4th 2019",bookSignature:"Anna Nowinska",coverURL:"https://cdn.intechopen.com/books/images_new/8633.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"261466",title:"Dr.",name:"Anna",middleName:"Karolina",surname:"Nowińska",slug:"anna-nowinska",fullName:"Anna Nowińska"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"274007",title:"Prof.",name:"Mandi D.",middleName:null,surname:"Conway",fullName:"Mandi D. Conway",slug:"mandi-d.-conway",email:"mconway1@yahoo.com",position:null,institution:null},{id:"283754",title:"Dr.",name:"Robin",middleName:"Demi",surname:"Ross",fullName:"Robin Ross",slug:"robin-ross",email:"robindross@email.arizona.edu",position:null,institution:null},{id:"284051",title:"BSc.",name:"David",middleName:null,surname:"Rosen",fullName:"David Rosen",slug:"david-rosen",email:"davidrosen@email.arizona.edu",position:null,institution:null},{id:"284377",title:"BSc.",name:"Leonardo",middleName:null,surname:"Montilla",fullName:"Leonardo Montilla",slug:"leonardo-montilla",email:"funrunner13@gmail.com",position:null,institution:null},{id:"284378",title:"MSc.",name:"Charles",middleName:null,surname:"Ingram",fullName:"Charles Ingram",slug:"charles-ingram",email:"cingram@optics.arizona.edu",position:null,institution:null}]},book:{id:"8633",title:"Novel Diagnostic Methods in Ophthalmology",subtitle:null,fullTitle:"Novel Diagnostic Methods in Ophthalmology",slug:"novel-diagnostic-methods-in-ophthalmology",publishedDate:"September 4th 2019",bookSignature:"Anna Nowinska",coverURL:"https://cdn.intechopen.com/books/images_new/8633.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"261466",title:"Dr.",name:"Anna",middleName:"Karolina",surname:"Nowińska",slug:"anna-nowinska",fullName:"Anna Nowińska"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11769",leadTitle:null,title:"Multiculturalism and Interculturalism",subtitle:null,reviewType:"peer-reviewed",abstract:"\r\n\tGlobalization and openness of the market for goods and services have contributed to the ever-increasing mobility of human talents across the globe. The historical background and evolution of societies have also created the co-existence of multiple cultures and modes of life. There are multiple cultures even within the border of the same country and there are multiple types of cultural differences among the habitants of a given country. Culture develops slowly its own norms, values, and beliefs regardless of the numerical size of its followers. Economic transactions and social cohesion cannot be conceived today without the consideration of cultural varieties and challenges. This is where we need to develop an in-depth understanding of culture and how we can function effectively within a multicultural society and economy. We invite book chapters from scholars exploring the cross-cultural, multi-cultural, and intercultural phenomena in our society and economy. We need to know how managers can effectively communicate, negotiate and lead the team within the cross-cultural business eco-system. Papers on Global Mindset and effective managerial approaches in the cross-cultural eco-system will be highly appreciated.
",isbn:"978-1-83768-144-0",printIsbn:"978-1-83768-143-3",pdfIsbn:"978-1-83768-145-7",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"6c4bda24f278d74f943f2155f13f4d73",bookSignature:"Dr. Muhammad Mohiuddin, Dr. Tareque Aziz and Dr. Sreenivasan Jayashree",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11769.jpg",keywords:"Professional Culture, Organizational Culture, Popular Culture, Cross-Cultural Conflict, Cross-Cultural Team Management, Cross-Cultural Management and Performance, National Culture, Individual Culture, Conducive Environment and Knowledge Sharing, Cultural Studies and Methodology, Cultural Diversity, Global Mindset",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 24th 2022",dateEndSecondStepPublish:"June 21st 2022",dateEndThirdStepPublish:"August 20th 2022",dateEndFourthStepPublish:"November 8th 2022",dateEndFifthStepPublish:"January 7th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"a month",secondStepPassed:!1,areRegistrationsClosed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"A reputed researcher in the cross-cultural management area with experience in teaching and research in the world's four continents.",coeditorOneBiosketch:"A pioneer in service sector development research in Bangladesh and officially the patent applicant and copyright owner of the “Service Quality Index (SQI)” certification in Bangladesh.",coeditorTwoBiosketch:"Dr. S. Jayashree is an associate professor at Multimedia University, Malaysia. She is pioneering research in Technology and the cross-cultural area and has demonstrated how to function effectively within a multi-cultural environment. Her research has been published in leading peer-reviewed journals and books.",coeditorThreeBiosketch:"Dr. S. Jayashree is an associate professor at Multimedia University, Malaysia. She is pioneering research in Technology and the cross-cultural area and has demonstrated how to function effectively within a multi-cultural environment. Her research has been published in leading peer-reviewed journals and books.",coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038UqSfQAK/Profile_Picture_2022-05-13T10:39:03.jpg",biography:"Dr. Muhammad Mohiuddin is an Associate Professor of International Business at Laval University, Canada. He has taught at Thompson Rivers University, Canada; University of Paris-Est, France; Osnabruck University of Applied Science, Germany; and Shanghai Institute of Technology and Tianjin University of Technology, China. He has published research in Research Policy, Applied Economics, Review of Economic Philosophy, Strategic Change, International Journal of Logistics, Sustainability, Journal of Environmental Management, Journal of Global Information Management, Journal of Cleaner Production, M@N@GEMENT, and more. He is a member of CEDIMES Institut (France), Academy of International Business (AIB), Strategic Management Society (SMS), Academy of Management (AOM), Administrative Science Association of Canada (ASAC), and Canadian council of small business and entrepreneurship (CCSBE). He is currently the director of the Research Group on Contemporary Asia (GERAC) at Laval University. He is also co-managing editor of Transnational Corporations Review and a guest editor for Electronic Commerce Research and Journal of Internet Technology.",institutionString:"Université Laval",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"Université Laval",institutionURL:null,country:{name:"Canada"}}}],coeditorOne:{id:"474140",title:"Dr.",name:"Tareque",middleName:null,surname:"Aziz",slug:"tareque-aziz",fullName:"Tareque Aziz",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003SaNGSQA3/Profile_Picture_2022-05-13T10:39:36.png",biography:'Dr. Mohammed Tareque Aziz is the country’s leading service sector management consultant. Currently, Dr. Aziz is the Dean and professor of relationship marketing and retailing at Green Business School (GBS) of Green University Bangladesh (GUB). He is a member of the editorial board of the Journal for Service Quality Improvement (JSQE). Officially the patent applicant and copyright owner of Bangladesh\'s "Service Quality Index (SQI)" certification. BRAC University and the University Grants Commission have named him a "Certified Academic Quality Expert." In addition, he is an honorary Senior Fellow at India\'s Centre for Advanced Studies in Policy Research (CASPR). He is on the International Fellowship Journal of Interdisciplinary Research\'s Editorial Advisory Board.',institutionString:"Green University of Bangladesh",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Green University of Bangladesh",institutionURL:null,country:{name:"Bangladesh"}}},coeditorTwo:{id:"154427",title:"Dr.",name:"Sreenivasan",middleName:null,surname:"Jayashree",slug:"sreenivasan-jayashree",fullName:"Sreenivasan Jayashree",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS8DPQA0/Profile_Picture_2022-05-13T10:37:31.jpg",biography:"Dr. S. Jayashree is an associate professor at the Faculty of Management (FOM), Multimedia University, Persiaran Multimedia, 63100, Cyberjaya, Selangor, Malaysia. She is pioneering research in Technology and cross-cultural area. Her research has been published in leading peer-reviewed journals and books. She has also presented her findings at many international conferences.",institutionString:"Multimedia University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Multimedia University",institutionURL:null,country:{name:"Malaysia"}}},coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"23",title:"Social Sciences",slug:"social-sciences"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"184402",firstName:"Romina",lastName:"Rovan",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/184402/images/4747_n.jpg",email:"romina.r@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"6926",title:"Biological Anthropology",subtitle:"Applications and Case Studies",isOpenForSubmission:!1,hash:"5bbb192dffd37a257febf4acfde73bb8",slug:"biological-anthropology-applications-and-case-studies",bookSignature:"Alessio Vovlas",coverURL:"https://cdn.intechopen.com/books/images_new/6926.jpg",editedByType:"Edited by",editors:[{id:"313084",title:"Ph.D.",name:"Alessio",surname:"Vovlas",slug:"alessio-vovlas",fullName:"Alessio Vovlas"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6942",title:"Global Social Work",subtitle:"Cutting Edge Issues and Critical Reflections",isOpenForSubmission:!1,hash:"222c8a66edfc7a4a6537af7565bcb3de",slug:"global-social-work-cutting-edge-issues-and-critical-reflections",bookSignature:"Bala Raju Nikku",coverURL:"https://cdn.intechopen.com/books/images_new/6942.jpg",editedByType:"Edited by",editors:[{id:"263576",title:"Dr.",name:"Bala",surname:"Nikku",slug:"bala-nikku",fullName:"Bala Nikku"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"54985",title:"Collaborative VLC/IROW Systems",doi:"10.5772/intechopen.68474",slug:"collaborative-vlc-irow-systems",body:'A visible light communication (VLC) system has the potential to become a complementary technology to its radio frequency (RF) counterpart, and this is due to the hundreds of THz of license free bandwidth, high security, energy efficiency and immunity to electromagnetic interference [1]. Despite the advantages presented by the VLC medium, there are several challenges facing VLC systems to achieve high data rates. These challenges include the low modulation bandwidth of the light-emitting diodes (LEDs) and inter-symbol interference (ISI) due to diffuse transmission where the optical signal reaches the receiver through a number of different paths that result in pulse spread, which in turn leads to ISI. Various techniques have been proposed to mitigate the limitations (low modulation bandwidth of LEDs and ISI) in VLC systems to achieve high data rates. On-going research activities intend to increase the data rates of indoor VLC systems by replacing LEDs with visible laser diodes (LDs) coupled with the use of an imaging receiver instead of the conventional wide field of view (FOV) receiver [2–5].
The concept of VLC systems is based on the use of light units (LEDs/LDs) for both lighting and communications. Therefore, using light units (i.e. LED or LD) for communications should not interfere with the light units’ main function (i.e. illumination). A user may arbitrarily dim the light source in the VLC system to save power, so it is essential to maintain communication in this case. An infrared optical wireless (IROW) system can be used to collaborate with the VLC system under partial/full dimming. IROW systems can provide high transmission rates similar to VLC systems [6, 7]. This is due to the wider modulation bandwidth of the laser sources used in IROW systems instead of white LEDs. IROW systems can use simple signal processing functionality and simple modulation formats while having a much higher bandwidth available for future usage. IROW systems have some additional advantages compared to VLC. For example, light dimming is not an issue in IR systems, and the uplink implementation using IR is convenient as it avoids bright visible light next to the user’s equipment, next to a laptop, for example. However, IROW systems have two major challenges: multipath dispersion due to reflections and sensitivity to additive shot noise coming from artificial background lighting or sunlight [6, 8].
The received power at the VLC receiver is reduced when the user dims the light to low levels, and this will lead to a degradation in the signal-to-noise ratio (SNR) and affect the data rate achievable. Recently, hybrid schemes were proposed to support VLC systems. RF-based systems are used to supplement the VLC system [9, 10]. However, achieving a high transmission rate (multi gigabits per second) and security is the most challenging parts. Therefore, the VLC link needs to collaborate with the IROW connection to provide continuous data transmission. When the VLC link has recovered (i.e. there is no dimming), the VLC and IROW systems can cooperate together to increase the data rate at the receiver side.
In this chapter, we addressed the weakness of VLC systems and provide practical solutions when the light is partially dimmed or totally switched off. Subsequently, we have achieved data rates more than those reported in Refs. [9, 10]. In this study, we report the use of infrared systems that utilise a LD source to support the VLC system when the light is totally switched off. IR optical communication has the same advantages as VLC systems. It can also provide high transmission data rates similar to VLC systems and potentially higher data rates (data rates up to 15 Gbps can be achieved) [11]. In addition, we investigate the performance of a VLC system under the impact of different levels of dimming, propose an adaptive rate technique (ART) and produce the concept of cooperation between VLC and IROW systems. The VLC system is able to achieve high data rates (5 Gbps) when the light units are “ON.” However, the achieved data rate (i.e. 5 Gbps) will decrease as a result of light dimming. Therefore, IROW systems are proposed to ensure the continuity of the wireless communication and to maintain the target data rate (5 Gbps), as the IROW system can be used to compensate for the degradation of the data rate due to dimming in the VLC system. In addition, the IROW system can be used to increase the data rates so they are higher than the target (5 Gbps) when the lights are “ON,” and the VLC system is operating normally.
Five IROW systems are proposed: hybrid diffuse IR (HDIR) with wide field of view receiver, HDIR with imaging receiver, beam steering IR (BSIR) with imaging receiver, cluster distributed IR (CDIR) with imaging receiver and a cluster distributed beam steering IR (CDBSIR) system, to collaborate with the VLC system. The data rates achieved by our proposed backup systems are 2.5 and 5 Gbps when using a very simple modulation format (on-off keying, OOK) and avoid the use of relatively complex wavelength division multiplexing approaches. In this study, we used two types of receivers: wide FOV receiver and an imaging receiver with selective combining (SC) to choose the best pixel.
The remainder of this chapter is organised into the following sections: Section 2 presents the simulation environment and VLC/IROW channel model. Section 3 presents the proposed systems’ configurations. Section 4 introduces the ART and the impact of dimming on the VLC system performance. Section 5 introduces the simulation results and discussion of the IROW systems. Section 6 provides the simulation results and discussion of the collaborative VLC/IROW system in an empty room. Finally, conclusions are drawn in Section 7.
To study the benefits of our proposed systems in an indoor environment, a simulation based on a ray tracing algorithm was performed in an unoccupied room (empty) with 8 m × 4 m (length × width) floor dimensions and a height of 3 m to the ceiling. The walls and ceiling were segmented into small reflective elements (
In indoor OW communication systems, intensity modulation with direct detection (IM/DD) is the preferred choice as a result of its reduced cost and complexity [17]. The receiver makes use of a detector that produces a photocurrent
where
where
The 3 dB channel bandwidth is equal to the frequency when the magnitude response falls by 3 dB.
The SNR of the received signal can be calculated by taking into account the powers associated with logic 0 and logic 1 (
where
where
where
In this section, proposed OW systems are presented, analysed and compared to identify a reliable and high data rate wireless communication system for an indoor user.
The imaging LD-VLC system used eight lighting fixtures (i.e. RGB-LDs) on the ceiling connected by fibre optic cable and controlled by a central controller. The imaging LD-VLC system was introduced in Ref. [2], and it is considered here to investigate its performance under the impact of different levels of dimming. In addition, it will be integrated with an IROW system to provide reliable and high data rate services for an indoor user. Figure 1 shows the architecture of the imaging LD-VLC system.
Architecture of imaging LD-VLC system with imaging receiver on communication plane.
In this section, five IROW systems are presented, analysed and compared to identify the most appropriate system for use to collaborate with the VLC system (imaging LD-VLC).
The HDIR employed one IR transmitter located at the centre of the ceiling, which can provide a direct LOS link at the receiver on the communication plane (CP). Figure 2 shows the HDIR communication architecture. In this case, most of the power is gathered from the LOS link, and the rest of power is collected through reflections. The proposed system (HDIR) uses a single-wide beam source, typically with a Lambertian pattern where the transmitted optical signal fully diffuses over the environment. The IR transmitter is connected to all the visible light sources via fibre links (to link to main network in the building) and simple control circuits (located at the centre of the room). When the light is dimmed or the received optical power falls below a certain threshold, a feedback IR signal at a low rate is sent by the receiver to the controller to switch the link into the backup system (i.e. HDIR). The receiver consists of the VLC and IR detectors connected through an electronic switch to control their functions. In this system, we used a conventional single-element wide FOV (90°) photodetector with photo sensitive area of 1 mm2. The HDIR transmitter is positioned at the centre of the room at (2, 4, and 3 m), is pointed downwards, and emits 1 W with an ideal diffuse pattern. Exposure to optical radiation at such power levels can be hazardous to the skin and eyes. Nevertheless, different techniques can be used to reduce the impact of the high laser power, such as extending the source size, destroying its spatial coherence using holograms mounted on the transmitter or the use of arrays of transmitters. Pohl et al. have shown that such a source may use an integrating sphere as a diffuser to emit optical power in the range from 100 mW to 1 W [21]. Therefore, a transmitter power of 1 W will be assumed in this system.
Architecture of HDIR with wide FOV receiver on communication plane.
The HDIR system with imaging receiver has a comparable room configuration and uses the same IR transmitter as the former system. However, a 50 pixels imaging receiver is used here. The imaging receiver shows two main pros over the traditional non imaging receivers. Firstly, all detectors share a common concentrator (e.g. a lens). Hence, it can be fabricated with a smaller size and lower cost. Secondly, all photodetectors can be placed on a single plane. Therefore, the designer can opt to use a larger number of detectors with small detector areas and narrow FOV. This will improve the receiver bandwidth (the input capacitance can be reduced by reduce photodetector area) and mitigate the effect of multipath dispersion. In this chapter, we employed the imaging receiver design proposed in Ref. [2].
In contrast to the HDIR, in the BSIR system, the IR transmitter uses beam steering to direct the IR beam toward the receiver position. The IR transmitter faces downward at the centre of the ceiling as shown in Figure 3.
Architecture of BSIR with imaging receiver on communication plane.
It has been proved that beam steering is an effective approach that can help to maximise the receiver’s SNR, regardless of the receiver’s FOV, the receiver’s orientation and the transmitter’s position [5]. However, this technique requires intensive time and calculations on the processor to generate a hologram at each step. In our new BSIR system, we propose an efficient stored vocabulary hologram method for beam steering in our backup system. For a large room of 4 m × 8 m, the floor (i.e. CP) is divided into 512 regions (0.25 m × 0.25 m per region). The total number of holograms to be stored in our design is
In the BSIR system, the transmitter emitted 100 mW, where the hologram used
In the CDIR system, IR transmitters are used that utilise LD sources to support the VLC systems when the light is partially dimmed or totally switched off. The CDIR system employs more than one IR source and distributes them on the ceiling, that is, each IR source is attached to a VLC transmitter (i.e. light unit). All IR sources are connected via fibre and a control unit to perform cluster mechanisms. The new concept of using IR clusters is employed to design a new geometry that can achieve a good performance in mobile IR communications.
A custom design for the imaging receiver (similar to the one in the previous systems) is used to reduce the impact of multipath dispersion and ISI. Figure 4 shows the architecture of our CDIR system. The proposed system consists of eight IR sources, and each is attached to a visible light source located on the ceiling, which can provide a direct LOS link to the receiver on the CP. The IR transmitters are connected to all visible light sources through fibre links (to link to the main network in the building) and simple control circuits. As shown in Figure 4, each IR source forms part of a cluster that can cover over 2 m × 2 m. When the light is dimmed or the received optical power falls below a certain threshold, the receiver sends a feedback signal at a low rate to the VLC transmitter to switch the link into the supporting CDIR system. A select the best (STB) algorithm is used (similar to the ones used in Ref. [22]) to select the optimum link between the IR transmitter and receiver (under mobility, this algorithm can be called periodically). The first step is to switch ON each IR source individually. Each source uses a single-wide beam, typically with a Lambertian pattern with
Architecture of CDIR when all IR transmitters are “ON”.
In contrast to the CDIR, in the CDBSIR system, the IR transmitter uses the beam steering technique to steer the IR beam towards the receiver location. Like CDIR, the CDBSIR system employs a STB algorithm to select the closest IR transmitter to the receiver. The selected IR transmitter in the STB algorithm will then apply a finite stored hologram in the system, instead of a diffuse source (as in the CDIR system). The stored hologram in the proposed system produces an IR beam to scan an area of 2 m × 2 m and steer the IR beam towards the receiver location. The floor (2 m × 2 m) under the IR source is subdivided into small areas; for example, we divided it to 256 subdivisions (0.125 m × 0.125 m) as shown in Figure 5. The IR transmitter divides the stored holograms into four quadrants with a boundary based on the hologram transmission angles (−
Architecture of CDBSIR system.
It is desirable to continue to provide a high data rate service, while a user dims the light source to any level. However, the received power at the VLC receiver is reduced when the user dims the light to low levels, and this leads to a degradation in the SNR and affects the achievable data rate. Therefore, a collaborative VLC/IROW system is introduced to address this issue, and when the VLC has partial dimming, such as 75 or 50%, both the IROW and VLC systems can collaborate to maintain the target data rate (5 Gbps). The IROW system can be used to compensate for the degradation of the data rate due to dimming in the VLC system. It should be noted that the IROW system sends information at a fixed rate of 5 Gbps. In the case of no dimming, the VLC and IROW can be used to increase the data rate higher than the maximum VLC data rate (i.e. higher than 5 Gbps); hence, the achieved data rate will be 10 Gbps instead of 5 Gbps. Figure 6 shows the architecture of the VLC/IROW system. The proposed system consists of eight IR sources (similar to those used in the CDBSIR system) and eight VLC transmitters (similar to those used in the imaging LD-VLC system) and employs an imaging receiver with 50 pixels. In order to eliminate interference between uplink and downlink channels, the downlink IR channel is used 850 nm and the IR uplink is used 1550 nm.
Architecture of VLC/IROW collaborative system.
In this section, we introduce the ART and evaluate the performance of the imaging LD-VLC system under the impact of multiple levels of light dimming (25, 50 and 75%). The results are presented in terms of the SNR at different operating data rates (5, 2.5 and 1.25 Gbps).
It should be noted that an SNR equal to 13.54 dB is needed for a 10−6 probability of error (BER). Therefore, we have chosen BER = 10−6 as the threshold in the imaging LD-VLC, and we employ an ART to ensure that we have an acceptable quality communication link under different levels of dimming.
ART is carried out at the receiver and the controller. First, the receiver monitors BER continuously, and when it becomes higher than 10−6, the receiver sends a feedback signal called the channel quality indicator (CQI) to inform the controller to move to the next transmission rate (lower transmission rate when the BER becomes higher than 10−6).
In our VLC system, we provide three data rates (5, 2.5 and 1.25 Gbps). For example, when the receiver is operating at 5 Gbps and the BER becomes higher than 10−6 (i.e. the SNR decrease below 13.54 dB), the receiver will send CQI_1 to inform the controller to reduce the transmission rate to 2.5 Gbps. Then, the receiver measures the SNR, and if the BER is still higher than 10−6, then the receiver will send CQI_2 to inform the controller to further reduce the data rate (i.e. from 2.5 to 1.25 Gbps). Again, if the BER is still higher than 10−6, then the receiver will send CQI_3 to inform the controller to stop transmission, and the communication link is disconnected. However, it is desirable to maintain communication, while a user arbitrarily dims the light source. Therefore, we have introduced a collaborative VLC/IROW system to address this issue (i.e. degradation in the SNR due to dimming will lead to disconnect in the communication link).
It should be noted that the ART has two procedures: down convert and up convert. Down convert is when the controller reduces the data rate due to degradation in the BER (when dimming occurs). Up convert is when the controller increases the data rate (e.g. from 1.25 to 2.5 Gbps) due to maintaining a very low BER at the receiver side (i.e. 10−9). The CQI_4 and CQI_5 signals can be used to inform the controller to increase the data rate from 1.25 to 2.5 Gbps and from 2.5 to 5 Gbps, respectively.
ART is carried out at the start of a one second frame, and if the BER has changed compared to the previous frame’s values, then the receiver uses the feedback channel to update the controller.
The ART (down convert) can be applied according to the following steps:
The receiver sends (using an infrared beam) a low data rate control feedback signal (CQI) to inform the controller that the BER has become lower than 10−6.
The controller decreases the current data rate to the lower service (e.g. 5–2.5 Gbps).
The receiver estimates the BER, and if it is still below 10−6, it will send another CQI to inform the controller.
The controller further decreases the data rates (e.g. from 2.5 to 1.25 Gbps), and if it receives another CQI from the receiver, the controller will stop the transmission.
A flow chart of the down convert ART is shown in Figure 7. To evaluate the performance of the imaging LD-VLC system at different levels of light dimming, the SNR was calculated at 5, 2.5, and 1.25 Gbps. Figure 8 illustrates the SNR of the VLC system when it was operated at 5 Gbps; the imaging LD-VLC system achieved about a 15.66 dB SNR at the room centre (worst case scenario) when dimming did not exist. However, it can be clearly seen that when the user dims the light by more than 25%, the SNR is decreased, and the BER becomes higher than 10−6. This means that the VLC system cannot operate at this data rate (5 Gbps) when the light is dimmed by more than 25%. Figures 9 and 10 show the SNR of the imaging LD-VLC system when operating at 2.5 and 1.25 Gbps, respectively. When the imaging LD-VLC is operated at 2.5 Gbps, it is able to maintain a BER of 10−6 at a dimming level of up to 50%. On the other hand, the VLC system has the ability to achieve 1.25 Gbps with a BER lower than 10−6 at deferent levels of dimming (25, 50 and 75%), as shown in Figure 10.
Flow chart of ART (down convert case).
SNR of imaging LD-VLC system operating at 5 Gbps with different levels of dimming (25, 50 and 75%) when receiver moves at x = 2 m along y-axis.
SNR of imaging LD-VLC system operating at 2.5 Gbps with different levels of dimming (25, 50 and 75%) when receiver moves at x = 2 m along y-axis.
SNR of imaging LD-VLC system operating at 1.25 Gbps with different levels of dimming (25, 50 and 75%) when receiver moves at x = 2 m along y-axis.
In this section, we evaluate the performance of the proposed support systems in an empty room in the presence of multipath dispersion, receiver noise, back ground noise (light units) and mobility. The results are presented in terms of delay spread and SNR.
A comparison of the channel delay spreads of our proposed systems is given in Figure 11. The receiver moves along the
Delay spread of IROW proposed systems.
The SNR evaluation of the proposed backup VLC systems was carried out under the impact of receiver noise, multipath propagation, background noise and mobility. The proposed systems were set to operate at 2.5 and 5 Gbps. Figure 12 shows the SNR of the proposed systems when operated at 2.5 Gbps. It can be noted that the HDIR system with wide FOV receiver does not have the ability to operate at a high data rate. However, when the imaging receiver is combined with this system, it can perform better than when using the wide FOV receiver. This is because the imaging receiver has ability to select the signals from the optimum pixels that monitor the best received signal during mobility. The imaging receiver uses a large number of detectors with a narrow FOV and small detector area. The HDIR system coupled with an imaging receiver provides around −2.3 dB at
SNR of IROW proposed systems when operating at 2.5 Gbps.
From Figure 12, we can notice that the HDIR (with wide and imaging receiver) and BSIR systems do not able to transfer data higher than 2.5 Gbps; therefore, in Figure 13, we only present results for the CDIR and CDBSIR at 5 Gbps. Figure 13 shows the SNR of the CDIR and CDBSIR systems when operated at 5 Gbps. It can be clearly seen that the CDIR system with imaging receiver does not have the ability to operate at a high data rate. However, when the beam steering technique is combined with this system, it can perform better. The significant improvement in the SNR level is attributed to the ability of the beam steering technique to steer the IR beam towards the receiver location and, thus, increase the power received by the pixels.
SNR of two systems operating at 5 Gbps when receiver moves at x = 2 m along y-axis.
It should be noted that only CDBSIR can operate at 5 Gbps. Therefore, we suggested that this system can collaborate with VLC system.
Dimming is an important feature of an indoor lighting system where the illumination level can be controlled by the user. One of the main issues in VLC systems is that the light unit should be “ON” all the time to ensure continuous communication. However, the user may dim the light at any time, and this will severally degrade the performance of the VLC system. In this section, collaboration between VLC and IROW systems (CDBSIR) is proposed to support the VLC system when the light is dimmed at different levels (25, 50 and 75%). An ART can be used with the VLC system to manage the reduction in the SNR due to the light dimming and to establish a high-quality communication link under the impact of dimming. To provide a high data rate service for an indoor user under different conditions (with\\without dimming), an IROW (CDBSIR) system can be used to support the VLC system. Figure 14 shows the SNR of the VLC system when the ART is carried out. It can be clearly seen that the data rate diminishes in a very graceful manner when the light is dimmed beyond 50%. However, when employing the CDBSIR system, the achieved data rates at the receiver will be 5 Gbps even though the VLC system is off. It means that the user can dim the lights and maintain a high quality communication service (5 Gbps and beyond). In the case of partial dimming (50 and 75%) in the VLC system, it can achieve 2.5 and 1.25 Gbps, respectively. Therefore, the collaborating system (VLC/IROW) can always achieve higher than the target data rate (5 Gbps). For example, 7.5 Gbps (2.5 Gbps from the VLC system and 5 Gbps from the CDBSIR) can be achieved when the light is dimmed by 50%. In the case of no dimming, 10 Gbps can be achieved by using both systems (VLC and IROW).
SNR of collaborative systems when receiver moves at x = 2 m along y-axis.
In this chapter, we proposed, designed and investigated the concept of a collaborative VLC/IROW system. In addition, we investigated the impact of partial dimming (25, 50 and 75%) on the performance of the VLC system. Moreover, we introduced a novel ART to reduce the effect of the dimming and to create an optimum communication link under the impact of partial dimming.
Five novel IROW systems (HDIR with wide FOV, HDIR with imaging, BSIR, CDIR and CDBSIR) were introduced to support and collaborate with the VLC system in the case of partial dimming or full dimming (i.e. lights off).
Simulation results show that the HDIR and the BSIR systems coupled with an imaging receiver achieved around −2 and 8.2 dB SNR at 2.5 Gbps, respectively. Further improvement in the SNR can be achieved by introducing a new CDIR system and employing more than one IR source distributed on the ceiling (attached to the VLC sources). The simulation results show that the CDIR system can significantly improve the SNR, as well as reduce the delay spread, compared to other systems. A beam steering technique is also proposed to further reduce the delay spread and increase the SNR by steering the IR beam nearer to the receiver at each given location. Simulation results show that the CDBSIR system has the ability to decrease the delay spread of the CDIR system by 90% from 0.03 to 0.003 ns at the room centre (
Simulation results show that the collaborative VLC/IROW system has the ability to achieve 10 Gbps when dimming does not exist and 6.25 Gbps (5 Gbps from the IROW and 1.25 Gbps from the VLC) in the case of 75% light dimming (worst case scenario). It should be noted that in a collaborative system, the receiver should employ VLC and IR detectors connected through an electronic switching mechanism to control their functions.
The authors extend their appreciation to the International Scientific Partnership Program ISPP at King Saud University for funding this research work through ISPP# 0093.
Increased environmental awareness has led researchers to find alternative solutions to replace petroleum-based materials in a sustainable manner. With an increase in world’s population, one of the most concerning problems the planet is currently experiencing is the cumulative waste from various industries. The world’s population produce an astounding 3.6 million tonnes of municipal solid waste each day. It is projected to rise to 6.1 million tonnes per day by the year 2025. It is adversely affecting health, contaminating our air, landscape, fresh water and ocean life. Waste valorisation is one method of managing waste in a sustainable manner and in return deriving a high-value product. The meat industry constitutes many by-products, which are under-exploited, from which a large number of valuable proteins, fats and chemicals can be derived from. Specifically related to the meat industry are tanneries and rendering plants, which process bovine and cattle hides for leather and fat production.
Hide off-cuttings, shavings and finished leather scrap are generated as waste in tanneries. These are currently disposed of in landfill sites and they have high landfilling costs per mass unit due to their low density and present low compaction ability. At best, the hide off-cuttings and shavings are converted to animal feed providing little or no economical or sustainable value, despite their content in valuable biopolymers. Bovine hides are rich in the valuable protein collagen, especially in the corium layer of the skin.
Considering the high cost of collagen and the vast number of applications and industries it can be of value, a more sustainable and a waste valorisation option would be to recover as much collagen as possible from hide off-cuttings.
Collagen is a structural protein, which provides strength, stability, and flexibility and is a major constituent of the skin tissue. Hence, bovine hides contain an abundance of collagen. The collagen molecule is a triple-helix comprised of three distinct alpha chains of repeating units of (GLY-X-Y)N amino acids, where X is often proline and Y is often hydroxyproline [1, 2].
Collagen is a highly sought-after protein, finding use in regenerative medicine, in cosmetics, used as casings, in supplements, films, pharmaceuticals, as a precursor to biodegradable materials, for use in tissue engineering and more recently in 3D printing [3, 4, 5, 6, 7, 8]. The demand for collagen is rising at approximately 20% annually and global collagen-based biomaterials market is predicted to reach US$5 billion by 2025. Specifically extracting bovine collagen has many advantages over other potential sources, such as having a higher denaturation temperature in comparison to collagen from marine sources, extracting fish and porcine collagen present limitations; applications of fish collagen are limited because of its lower hydroxyproline content [9] and porcine products are prohibited by Muslim and Jewish communities [10].
This chapter aims to represent a background on waste generation in tanneries, to use the tannery waste bovine hide off-cuttings for extraction of high value collagen. Further, collagen extraction methodologies are discussed in detail and finally methods used to investigate physicochemical properties of collagen are reviewed.
In recent years waste valorisation has attracted a significant amount of attention with the sole aim of managing waste in the most sustainable way. Waste from various industries is one of the most concerning problems the planet is currently experiencing and will increase with the increase in population and needs to be addressed. The meat industry constitutes many by-products that are under-exploited, from which a large number of valuable proteins, fats and chemicals can be derived from.
Tanneries and rendering plants process bovine and cattle hide for leather and fat production. Casualty and cattle used for meat consumption result in a large quantity of waste and one of the most valuable by-products is the bovine and cattle skins or hides.
Industrial rendering separates animal by-products into value-added products such as animal protein meal and rendered animal fat and tanneries aim to process hides into leather, however, a substantial amount of waste is still produced from these processes that can be used to derive high-value products. Collagen is such a product that can be extracted from hide off-cuttings that is additional waste generated during leather preparation steps. Considering the high cost of collagen and its vast number of applications, extraction of such high-value product from bovine hide off-cutting is both sustainable and economical.
As much as this sector is considered to play a vital role because it recycles and reuses the by-products of the meat industry, the processes carried out in the different stages have a serious environmental impact. Environmental concerns that result from tanneries are due to resource consumption such as water, chemicals, energy and the generation of emissions such as volatile organic compounds, wastewater and solid waste. Moreover, hide off-cuttings, trimmings, hair and fleshings are removed from the hides during the tanning process. Only about 25% by weight of raw salted hides results in the finished leather [11]. Furthermore, other solid wastes are also produced from wastewater and sludge treatment.
Figure 1 shows the stages carried out in a tannery and post tanning in order to convert hides into leather. These steps result in the release of corrosive gasses into the atmosphere and in large quantities contaminated wastewater. Though leather is used for many applications, from furniture to bags and shoes and is economical in many industries, some bovine hides such as bull-hides are often too thick to process and requires additional processing steps for thinning of hides.
Process flow of waste valorisation from tanneries to collagen extraction and possible collagen-based applications.
During the conversion of bovine hides into leather (Figure 2) a vast number of chemicals are released into the environment and waste products are generated at each stage. Table 1 is showing chemicals used and wasted generated at each stage of leather production.
Process flow of transformation of hides into leather [
Tanning step | Chemicals | Wastes generated |
---|---|---|
Preservation | ||
Salt | Contaminated salt, raw hide trimmings | |
Soaking | ||
Water, surfactants, and enzymes | Salted and contaminated wastewater | |
De-hairing | ||
Water, sodium sulphide, and enzymes | Hair, alkaline water | |
Fleshing | ||
Water, mechanical processes | Flashings, alkaline water | |
Splitting | ||
Skin/hide | Limed hide | |
De-liming | ||
Water, ammonium sulphate and weak acids | Acidic wastewater |
Chemicals used at each stage of hide to leather conversion and wastes generated [13].
As bovine hides are being converted to leather, additional waste is generated during the preparation steps. Collagen-rich hide off-cuttings, trimmings and defected parts end up in landfill or at best as animal protein feed which is of low value considering the processing costs.
Bovine hide off-cuttings, trimmings and potentially bull-hides that are too thick to process for leather production and calf-hides that have defects can be used for collagen extraction. Collagen is the most abundant protein found in the mammalian body, making up approximately 30% of the total body protein. This structural protein which provides strength, stability and flexibility is a major constituent of skin tissue [14] and hence bovine hides are rich in collagen, especially in the corium section of the hide [15].
Hide off-cuttings can come from various bovine sources, such as bull, cow, ox, calf and even bovine face-piece hides. Additional to bovine hide off-cuttings, bull-hides that are too thick to process and require additional thinning processes can also be used for collagen extraction. This reduces extra processing costs and can directly be used for collagen extraction.
Bovine hide off-cuttings can be processed for collagen extraction. This collagen can be used by various industries for many applications from biodegradable films, pharmaceuticals to cosmetics. Several methods and techniques can be applied to extract collagen from bovine hide off-cuttings and the most efficient, economical and environmentally favourable methods can be worked with in order to reduce chemical and solid waste. Further, the market value of collagen is a lot more than leather, ranging from $37 per gram to as high as $1000 per gram for native lab-grade collagen [16].
Collagen is the most abundant structural protein found in the vertebrate body. Collagen is a rigid, inextensible, fibrous protein that is the principal component of connective tissue in animals, including tendons, cartilage, bones, teeth, skin and blood vessels. As a structural protein it is mainly used to give strength to structures in the body, however, it has different functions depending on the location of the body [17]. One-third of the total protein content in the mammalian body is collagen and accounts for three-quarters of the dry weight of the skin.
The triple-helix of collagen consists of three distinct alpha chains coiled around each other and this is termed as tropocollagen. The tropocollagen units are arranged as fibres or sheets. A tropocollagen unit is about 285 kDa, 3000 Å in length and 15 Å in diameter. The triple helix is composed of repeating units of (Gly-X-Y)N amino acids, where X and Y are any amino acids, however, often X is proline and Y is hydroxyproline. The individual polypeptide chains of collagen each contain approximately 1000 amino acid residues. The accurate folding of these chains requires a glycine residue to be present in every third position of the polypeptide chain [1]. One-third of the amino acids in collagen in glycine and it always occupies the first position of the triplet. This is due to glycine being a small and an uncharged amino acid near the axis of the collagen triple helix. Glycine is a very crucial part of collagen molecule inherent characteristic as substitution of a single glycine for another amino acid disrupts the triple helix and results in skeletal deformities such as ontogenesis imperfect.
Imine acids make up approximately 25% of the residues in the collagen triple-helix. Imine acids – proline and hydroxyproline are typically found around the outside of the trip helix and the pentagon structure of these two amino acids includes the amine nitrogen and the α-carbon of the backbone chain. These limit the possible rotation in the amino acid (Figure 1) and hence forcing each collagen chain to form a left-handed helix. The high content of these imine acids makes the α-helix and β-sheet arrangements (generally found in proteins) unstable. Collagen triple-helix is held together by hydrogen bonding between chains. The NH group in glycine in polypeptide chains forms H-bonds with adjacent peptide CO groups of the other chains.
After the formation of the collagen polypeptide chain, proline in the third position of the triplet in the amino acid sequence is hydroxylated by the enzyme propyl hydroxylase. The hydroxyl groups of the hydroxyproline and water molecules form hydrogen bonds that stabilise the triple-helix. Inhibition of hydroxylation causes diseases such as scurvy (caused by a lack of vitamin C in the diet) which is the inability of the triple-helix to form at body temperature (37°C) [18]. A decrease in imine acids (proline and hydroxyproline) content lowers the thermal stability of collagen as collagen loses its helical structure and shrinkage or denaturation occurs [18]. Avian and mammalian collagen have very similar amounts of hydroxyproline at 13.5% of the total amino acids. In comparison, aquatic animals have a lower level of hydroxyproline at approximately 10.3% [19].
The alpha-triple helix of collagen is shaped into a right-handed helix. The alpha chains each are shaped into a left-handed symmetry (the opposite direction), and then three of these alpha coiled strands get together to form a right-handed triple helix so when under strain, the chains twist into each other, giving strength and preventing unravelling. Each alpha helix is approximately 1.4 nanometres in diameter and 300 nanometres in length (approx. 1000 amino acids). The collagen molecule can be composed of either three identical alpha chains (homotrimers), or two or three different alpha chains (heterotrimers), however, the chain configuration depends on the collagen type being synthesised [2]. The hierarchical structure of collagen is zoomed-in starting from the alpha chains coiling together to form the triple helix is shown in Figure 3.
Collagen structure being broken down to fibre, fibril, triple helix and an alpha chain respectively [
Cross-links that are covalent bonds occur between the ends tropocollagen before the formation of the collagen fibre. The triple helix and the cross-linking give rise to a collagen material that is very rigid, inextensible and stable. Since collagen on the primary level is composed of repeating units of Gly-X-Y amino acids, it is therefore rich in carboxylic acid groups, hydroxyl groups, amide and amine groups. The triple helix structure is stabilised by inter-chain hydrogen bonding and triple helix (tropocollagen) molecules parallel to each other are covalently cross-linked with each other through their aldehyde and amino groups, forming collagen fibrils. There are multiple types of hydrogen bonding patterns found in the triple-helix. These include, i) direct hydrogen bonding among the peptides (i.e. the NH group in glycine in each polypeptide chain forms H-bonds with adjacent peptide CO groups of the other chains), ii) water-mediated hydrogen bonding linking carbonyl groups, and iii) water-mediated hydrogen bonding, which links hydroxyproline OH groups and carbonyl groups. Collagen self-organisation forms bundles or a meshwork that determines the tensile strength and the elasticity and geometry of the tissue.
The various collagen types are distinguished by the ability of their helical and non-helical regions to associate into fibrils and to form sheets or to cross-link different collagen types. For example, a two-dimensional network of type IV collagen is unique to the basal lamina. Most collagen is fibrillar and is composed of type I molecules (Figure 4) [2].
structure of collagen, with b) procollagen (loose ends), triple-helix wound together and c) collagen subunit tropocollagen (loose terminal removed) for final self-assemble of the collagen fibril and fibre (d-f) [
Tropocollagen is produced by fibroblasts found in connective tissue in mammals and birds. The collagens α-chains are translated on the rough endoplasmic reticulum (RER). Inside the ER hydroxylation of the specific proline and lysine residues occurs, however lack of vitamin C will hinder this step. Inside the Golgi apparatus glycosylation of pro-α-chain lysine residues and formation of procollagen occurs. Procollagen molecules are exocytosed into extracellular space. The rest of the synthesis steps occur outside the fibroblasts. Procollagen peptidases cleave terminal regions of procollagen, transforming procollagen into insoluble tropocollagen. Many staggered tropocollagen molecules are reinforced by covalent lysine-hydroxylysine cross-linkage (by Lysyl oxidase) to make collagen fibrils. Lysyl oxidase requires copper (Cu++) for its activity [22].
The assembly of collagen fibrils into parallel bundles forms collagen fibres that have high strength and flexibility. When tropocollagen is assembled into collagen, it forms fibrous or sheet-like staggered structures. These fibrous structures have striations every 680 Å consisting of a dense-packed region where fibres overlap, and a loose-packed region is formed (Figure 5). In one single row, tropocollagen units are separated by 400 Å gaps, and these gaps are found in the loose-packed region. If the tropocollagen rows are aligned next to each other, each adjacent row is offset by 680 Å, forming a structure that repeats every five rows.
Collagen fibre showing the striations where tropocollagen is densely packed (light sections) [
Hydrophobic and charged amino acid residues along the length of tropocollagen cause the staggered arrangement of tropocollagen. Tropocollagen units are aligned where the sum of the hydrophobic and charged region interaction between two units is strongest, hence the 680 Å staggering between units.
Inter-and intra-molecular covalent cross-links are formed between and within tropocollagen (collagen triple-helix) units giving strength to collagen fibres. Intramolecular cross-links form between adjacent lysine groups and within individual triple-helix units and intermolecular cross-links occur between two triple-helix units comprising of two hydroxylysine groups and a lysine group.
The enzyme Lysyl oxidase converts the NH3+ group on the lysine and hydroxylysine sidechains to an aldehyde that then undergoes a condensation reaction forming an adol cross-link with other converted lysine sidechains. In each tropocollagen unit, four groups can contribute in the intermolecular cross-linking; lysines near the amino and carboxyl ends in the non-helical regions and hydroxylysines in the helical region. A hydroxyl-pyridinium cross-link is formed between one lysine and two hydroxylysine between residues near the amino-acid end of one tropocollagen unit and the residues near the carboxyl-end of an adjacent tropocollagen unit. The enzyme Lysyl oxidase is small enough to fit between the 400-Å gaps between the triple-helix molecules to initiate the intermolecular cross-linking.
Collagen maturity or the amount of cross-linking increases drastically with age of the tissue and depends on the type and function of the tissue where collagen is found.
Collagen has a wide range of structural roles in mammalian and aquatic tissue. It is the major constituent of skin, bone, tendon, cartilage, blood vessels and teeth. Collagen is found in almost every organ of the body, starting from skin to the cornea of the eye. To serve functions in such diverse tissues, there are different types of collagen that differ in how they interact with each other and with other tissue.
There are more than 28 types of collagen identified. Collagen types I, II, III are the most abundant and most investigated for various applications. However, over 90% of the collagen found in the body is type I. The variations are due to the differences in the assembly of basic polypeptide chains, different lengths of the helix, and differences in the terminations of the helical domains [24].
Each collagen molecule is composed of three different polypeptide chains (α1, α2, and α3). Each chain is identified by its amino acid composition (Table 2). Collagen type I, for example, is identified for its constitution of α1 (I) and/or α2 (I) chains. The most commonly occurring variant of type I collagen consists of two α1 (I) and one α2 (I) chain. The alpha symbol is used to indicate a single chain component seen after collagen denaturation and the letter β, γ, and δ have been used to indicate covalently linked dimers, trimers or tetramers of the alpha chain.
Function | Description |
---|---|
Structural integrity | Collagens within the body serve largely for the maintenance and structural integrity of tissues and organs. |
Entrapment and storage | The collagen within the body fulfils the role of entrapment, local storage, delivery of growth factors and cytokines and hence it plays an important role during organ development, wound healing and tissue repair. |
Biodegradable | Collagen possesses the feature of being biodegradable and low immunogenicity. |
Variety of applications | Collagen has been used in many industries, from the biomedical, cosmetic, pharmaceutical, leather, film industry to tissue engineering. |
Collagen and its features [25].
The most common types of collagen are:
Collagen type I: found in skin, tendon, organs and bone tissues.
Collagen type II: main component of cartilage.
Collagen type III: the main component of reticular fibres, alongside type I.
Collagen type IV: Forms the bases of the cell basement membrane.
Collagen type V: the main component of cell surfaces, hair and placenta.
As collagen is one of the most abundant proteins on earth, it can be extracted from various sources. Collagen can be extracted from almost every living animal, including alligators and kangaroos. However, common sources of collagen for the food industry and tissue engineering applications include bovine skin and tendons, porcine skin and rat-tail. Collagen can also be extracted from marine life; it can be extracted from sponges to fish and jellyfish. All collagen sources are worth investigating as each source differs in the collagen type in terms of characteristics.
Collagen is extracted from many different sources; however, bovine collagen is seen to be the most used collagen type in a variety of different applications, such as the food industry, cosmetics, and medical applications. As the name implies, bovine collagen is a by-product of cows, mainly from the hides. It is a naturally occurring substance found in the skin, muscle, bones and tendons of cows. In the 1970s, the research on bovine collagen gained momentum, as researchers developed a system of extracting collagen and processing it in a liquid form [26].
The natural, unbleached skin and hair of cattle is the bovine hide (skin). Bovine hides are a by-product of the food industry from cattle. Bovine hides without complex processing can be manufactured into leather, which in turn can be used in the shoes and clothing industry. However further complex processing of the hides can be carried out to obtain the corium section of the hide for a variety of different medical and scientific applications [27]. One of the main applications of the corium is in the production of collagen.
Animal hide constitutes 60–65% water, 25–30% protein and 5–10% fats. The protein is mainly collagen [28]. Raw hides have four main parts; epidermis (6–10%), grain (less than 10%), corium (55–65%) and flesh and the thickness vary all over the animal (Figure 6) [29].
The approximate composition of bovine hide [
The epidermis and flesh layers are removed during tanning leaving the grain and corium layers. The grain is made up of collagen and elastin protein fibres. The corium is packed with collagen protein fibres. The thickness of corium also increases with age [30].
Each section of the animal hide for its properties is discussed further [29] (Figure 7) [29]:
Structure of bovine hide [
Collagen from aquatic animals have been used as a safe substitute for bovine collagen, this is due to collagen from bovine sources have shown to be contaminated with some diseases. Fish solid wastes constitute 50–70% of the original raw material; however, this depends on the method of meat extraction [6].
Shark type I collagen forms fibrils under different conditions compared to bovine and porcine collagen [32]. For example, shark type I collagen gels and membranes have stronger rigidity and higher affinity to water vapour than those of porcine collagen, thus indicating the potential for utilising shark collagen as a new type I collagen material for various uses such as cell culture and medical technology [33].
Pigskin is a by-product of the pork production industry. Collagen extracted from pigskin or bone is not favourable to be a component of foods or pharmaceuticals due to religious objections. Porcine collagen type I is extracted from pig hides, and in the medical field. Porcine collagen sheet material has proven to be useful as an implant for reconstructive surgery [34].
There are many collagen-producing companies in around the world. However, not all of them produce 100% pure collagen but rather gelatine (hydrolysed collagen). These companies lack further innovation with the collagen, thus distributing the collagen in powder or liquid form to pharmaceutical and research industries. Therefore, extracting collagen from bovine hides and using this collagen to investigate high value applications would possibly generate huge economic potential for a product that is derived of waste materials.
Collagen plays an important role both in the mammalian and the non-mammalian body and in its extracted form. Due to collagen’s high mechanical strength, it finds applications in several different industries, ranging from biomedical to the food industries.
Gelita is the world’s leading supplier of hydrolysed collagen proteins for the food, health and pharmaceutical industries. Gelita is based in numerous locations around the world with its headquarters in Germany [35]. However, the collagen Gelita produces is not 100% native collagen but hydrolysed collagen, in other terms it is gelatine.
Based in Napier New Zealand, Southern Lights Biomaterials was founded in 2003. They provide high-quality processed and semi-processed biomaterials to medical device manufacturers across the globe. One of their flagships processed products is polymeric collagen, which is delivered to contracted customers [36].
The polymeric collagen produced by Southern Lights Biomaterials is type I collagen derived from bovine tendon and is naturally cross-linked [36]. They do not take advantage of using cattle hides or face-pieces. Their collagen is sold to independent contractors without further processing.
Revolution Fibres produce and market nano-fibre and nano-fibre products. Based in Auckland New Zealand, Revolution Fibres has developed its own technology for the industrial production of nano-fibre. This technology is called electrospinning [37]. Revolution Fibres manufacture biodegradable air filters from nano-particle sized fibres that are ‘electro-spun’ from collagen extracted from Hoki fish skins. They have launched a skincare range using collagen fibres to deliver plant extracts into the skin [38].
Waitaki Biosciences based in Christchurch New Zealand manufactures speciality nutritional supplement ingredients from natural, biological sources. Waitaki Biosciences aims to target joint and bone health, immune and digestive support, along with skin and hair care. Marine collagen, natural collagen and chondroitin complex are some of their products [39]. The marine collagen produced by Waitaki Biosciences is in powder form, with a blend of ingredients selected from marine species. This marine collagen is designed for use as an oral supplement to support skin, nail and hair health [40].
Observing the collagen suppliers in New Zealand, there is a clear shortage in further innovation with the extracted collagen. Most of the above collagen suppliers distribute the collagen in a powder form or a liquid solution and export to external markets or distribute to local contractors. This collagen once supplied to contractors is usually blended in cosmetic products or encapsulated as pills in the pharmaceutical industry.
Collagen has been widely used in a range of applications in cosmetic, biomedical, pharmaceutical, film industries, tissue engineering and recently in 3D/bio-printing.
Collagen sponges
The collagen sponges act as a biological absorbance material. They have been useful in the treatment of severe burns and as a dressing for pressure sores, leg ulcers and donor sites. Collagen sponges can absorb large quantities of tissue exudate, smooth adherence to the wet wound bed with preservation of low moist climate as well as shielding against mechanical harm and bacterial infection [41].
Collagen sponges have also been found to be effective as drug delivery systems. For example, the collagen sponges were found to be suitable for short term delivery of antibiotics, such as gentamicin [42].
Collagen shields
Originally, collagen shields were designed for bandage contact lenses. However, it’s mostly used as a delivery device and has led to the development of drug delivery systems for ophthalmic applications [43]. For example, the collagen corneal shield is produced from porcine sclera tissue that closely resembles collagen molecules of the human eye. The collagen corneal shield promotes epithelial healing after corneal transplantation [44].
Collagen mini pellets
A mini pellet made from collagen is usually a rod with a diameter and length of 1 mm and 1 cm respectively. These are very useful as a drug delivery device. This is because the mini pellet (rod) is small enough to be injected into the subcutaneous space through a syringe needle and still spacious enough to contain large molecular weight protein drugs, such as interferon [42].
Skin replacement
Collagen has been widely used as vehicles for transportation of cultured skin cells or drug carrier for skin replacement and burn wounds [45]. Type I collagen is suitable for skin replacement and burn wounds due to their mechanical strength and biocompatibility [7].
Bone substitutes
Collagen has been previously used as implantable carriers for bone inducing proteins [41]. Due to osteo-inductive activity; collagen itself has recently been used as bone substitutes [42]. Collagen combined with other polymers has been used for orthopaedic defects. Demineralised bone collagen in combination with hydroxyapatite was used as a bone graft material to treat acquired and congenital orthopaedic defects in rats [46].
3D printing and collagen
3D printing is the process of converting digital designs to three-dimensional solid objects. 3D printing works by initially designing a 3D image of the desired object, with computer-aided design (CAD) [47]. The object is divided into digital cross-sections by the program so that the printer can build the object layer-by-layer. Once the specified design is sent to the 3D printer, a specific material can be chosen. Depending on the printer type, this material can be rubber, plastics, paper, metals and more [48]. However, in the case of bio-printing; bio-ink (cells) and bio-paper (collagen, nutrients) are required [49].
Collagen has shown to have positive effects on rheumatoid arthritis and osteoarthritis [50]. Published studies [51] have reported that ingestion of type II collagen relieves joint discomfort associated with osteoarthritis and rheumatoid arthritis. The authors also conducted a randomised trial involving 60 patients with severe active rheumatoid arthritis; a decrease in the number of swollen joints and tender joints occurred in subjects fed with type II collagen [51].
Collagen has great tensile strength and being rich in proline and hydroxyproline, it is the main component of fascia, cartilage, ligaments, tendons, bone and skin. Having these properties, it is responsible for skin strength and elasticity. Its degradation leads to wrinkles that accompany ageing. Collagen has become a valuable ingredient of many cosmetic formulations. Cosmetic uses include skin and hair products. Collagen type III is predominant in young skin; it is referred to as “restructuring” collagen as it appears during the wound healing process [7]. With ageing collagen type III decreases leading to wrinkles and lines, thus moisturising creams and cosmetic injects containing collagen have become in high demand [52].
Bovine collagen has been the most widely used source for cosmetic applications. Recently, collagen from other sources such as fish skin, pigskin, and range of cattle skin has been used in the cosmetics industry. However, collagens from various sources differ in their physiochemical properties. For example, they all have different thermal stabilities, and this can affect the formulation or the shelf life of the products [3].
Thin films or biodegradable films are flexible, transparent and often strong materials derived from natural polymers such as whey protein, collagen, starch, gelatine and many other natural renewable polymers [53, 54]. Due to rising environmental concerns, biodegradable films have attracted considerable attention especially from the food and drug packaging industries as they in constitution with other natural polymers can potentially replace plastic films which are derived from synthetic polymers [55].
Due to collagen being a biodegradable, biocompatible and a non-toxic polymer it has been used in the meat industry to form edible films and coatings through extrusion [56]. Collagen-based films in constitution with other biodegradable materials have been prepared in several studies to be used as packaging materials. Collagen’s high tensile strength and the added advantage of biodegradability makes it an ideal agent for natural polymer films.
One of the main applications of collagen films in the biomedical industry is as a barrier membrane. These collagen films have been used for slow-release drug delivery and they have been used for the treatment of tissue infection, such as infected corneal tissue or liver cancer [42].
Edible films and coatings are a category of packaging materials. They differ from other bio-based packaging materials, and conventional packaging, by being formed from edible ingredients. These films and coatings may be used to reduce the amount of synthetic packaging used in a product or allow conversion from a multi-layer, multi-component packaging material to a single component material. The purpose of edible films and coatings may be to inhibit migration of moisture, oxygen, carbon dioxide and or to improve the mechanical integrity or handling characteristics of the food. Edible films may also be used to separate different components in multi-component foods, thereby improving the quality of the product. Edible films may also help to maintain food quality by preventing moisture and aroma uptake or loss after opening of the synthetic packaging.
The use of natural polymers such as collagen for film preparation has many advantages over synthetic and petroleum-based polymers. Biopolymer films for the purpose of packaging materials have the advantages of biodegradability, renewability, and environmental compatibility. Collagen also has good film-forming properties, high tensile strength, good thermal stability, and the fact that the collagen is derived from waste hide off-cuttings presents a sustainable solution. One drawback of collagen-based films is the inflexibility of films. However, this can be overcome by the addition of plasticizers to improve the flexibility and elongation (%) properties of the films. The use of plasticizers has been shown to provide improvement of films in terms of flexibility and elongation; however, this is generally at the expense of strength and stiffness. The effect of plasticiser concentration should, therefore, be investigated to identify best concentration results in the optimum mechanical, thermal and physical properties.
Biopolymer films made for the food industry as coatings or packaging needs to be transparent, have desirable tensile strength and elongation, it should be edible and possibly have a high resistance to transmission of liquids, gases and fats and oils. However, the above criteria will vary depending on the food industry application of the film.
Sionkowska et al. [57] prepared biopolymer films based on blends of collagen and silk fibroin. Films were prepared by method solution casting and characterised for their mechanical properties and structure. Film blends of collagen and silk fibroin showed better mechanical properties than for pure silk fibroin films. Sionkowska et al. [57] concluded that the better mechanical properties of the blend films were due to molecular interactions between collagen and silk fibroin. No plasticizing agent was added in the preparation of collagen and silk fibroin blend films. This would result in a very brittle and stiff film due to interactions between protein chains through hydrogen bonding, electrostatic forces and hydrophobic interaction [58]. Hence the per cent elongation values of the film blends were very low (0.30–5.10%) [57].
Not all collagen extraction methods result in a collagen product that will be suitable for film preparation. Hence, to develop a collagen film with desired properties, it is necessary to investigate the various processes to prepare acid/alkaline/enzyme/acid-enzyme collagen that could easily be used as a raw material for extruded or casting of collagen-based films. O’Sullivan [6] reported that hydrochloric acid solubilisation extraction method of collagen is not favourable for the fabrication of edible films. However, acetic acid solubilisation with further processing gave a suitable collagen product as a raw material for the fabrication of edible film fabrication.
Every bovine collagen extraction procedure is restricted to the following four variable conditions:
De-hairing, cleaning and storage of the hide section off-cutting.
Cutting the de-haired hide section into approximately 1 cm x 1 cm pieces.
Extraction temperature: For bovine tissue, the extraction procedure can be carried out at room temperature, as collagen denaturation temperature for bovine is ∼39°C. However, it is preferable to extract collagen at a temperature of ∼4°C to prevent contamination.
Solubilisation: acid solubilisation, acid and enzyme solubilisation, or modified methods combining acids and enzymes.
Prior to collagen extraction, the sample is chopped to increase the extraction surface area and to speed up the extraction process. However, the temperature of the sample needs to be monitored, as high temperatures will unravel the tropocollagen making it soluble in solution, resulting in gelatine (denatured collagen). This greatly reduces the value of the protein, thus if native collagen is desired, any heating or denaturation of collagen should be avoided at every step of the process. Bovine collagen extraction is mostly carried out at temperatures of approximately 4°C to prevent bacterial contamination [9].
Collagen from juvenile sources (e.g. new-born calves or chicken embryos) will readily swell and dissolve in a low concentration of acetic acid solution and can be recovered by precipitating out the collagen by adding 1 to 5 M NaCl. However different types of collagen from different tissues will precipitate at different NaCl concentrations [59].
The older the animal/tissue sample, the greater the amount of lysine-hydroxylysine covalent cross-links that form between tropocollagen units. These cross-links typically form between the unwound part of a tropocollagen strand and another part of another tropocollagen unit, improving structural strength and chemical resistance of collagen, making the sample largely insoluble in acetic acid. The amount of cross-linking depends on the type of tissue (i.e. tendons are highly cross-linked to give strength) and age of the tissue (i.e. mature sources, such as bull-hides have high cross-linking in comparison to younger sources such as calf-hides) [60]. In order to dissolve mature collagen, pepsin enzyme can be added to the acetic acid solution, which attacks and cleaves the unwounded part of tropocollagen, allowing the tropocollagen units to separate and dissolve [59].
The following sub-sections discuss the main extraction steps/parameters or variables in more detail.
To prevent collagen denaturation and contamination, majority of the researchers carry out the collagen extraction process at approximately 4°C. Contamination occurs due to thermal denaturation or microbial degradation (Table 3).
Once the collagen source is de-haired, sized and cleaned it is then processed for defatting. Majority of collagen extraction processes defat the tissue of interest with an organic solvent or detergent prior to extraction (Tables 4 and 5).
Contaminating proteins need to be removed after defatting and demineralization. Most collagen extraction methods utilise salt or alkali solutions to solubilise the contaminants. Collagen is a lot more chemically resistant than most other proteins therefore, it is much less likely to be degraded or solubilised by a weak salt (Table 6).
There are various methods to extract collagen from different animal tissues. The methods used to extract collagen from bovine or any other tissue such as fish skin; pigskin, rat tail, tendons etc. vary slightly, differing in enzyme concentration, acid concentration, salt concentration or pre-treatment period [6]. These variations can be studied and the most optimal method for bovine hide extraction can be obtained. However, acid extraction which results in acid-soluble collagen (ASC), pepsin extraction that gives pepsin solubilised collagen (PSC) and salt extractions. Some of the main extraction procedures found in literature are discussed in detail below [80].
This method is seen as the least favourable method of collagen extraction. Collagen proteins, like general proteins have the property of being salt soluble. Different types of collagen proteins can be separated using the relationship between different collagen sources and salt concentrations. Neutral salt solutions are usually used, such as NaCl, Tris–HCl, phosphate, or citrate. In the salting-out method, the concentration of salt is the key factor to control, if for example, the concentration of NaCl is less than 1 mol/L in the neutral solution, its suitable for dissolution of type I collagen, however, if the concentration is bigger than 1 mol/L, it will precipitate the type I collagen. Since mature sources of collagen are less soluble because most collagen protein molecules have cross-linked, the salting-out method is not an efficient method alone to extract collagen [80].
The main chemicals used in the alkali method of collagen extraction are sodium hydroxide and monomethylamine [81]. This extraction method is not favoured as the main extraction method due to similar reasons as the salting-out method.
Hattori et al. [81] prepared collagen from bovine hides by alkaline solubilisation with 3.0% NaOH and 1.9% monomethylamine. The study also extracted bovine hide collagen by acid and enzymatic methods for comparison. These methods were carried out on animals of different ages. The amount of collagen extracted through this method was estimated by comparing the hydroxyproline content in the whole hide with that in the extracted collagen.
The alkali-enzyme method is not as effective as the acid-enzyme method. This is because alkali is such as NaOH does not have the ability to fully solubilise collagen and disrupt the cross-linking in a collagen molecule. This method is more preferred for gelatine production [80].
A series of repetitive steps having acid then alkali soaking of samples for a long period can be used to extract collagen. However, this method requires a very long period and the reaction time is very slow. It does not work for mature tissues as it is near impossible for acid and alkali alone to disrupt the cross-linking developed in mature tissue, thus an enzyme is a must requirement. The collagen yield extracted decrease or increase for the same tissue type depending on the literature. These differences are due to denaturation of protein during the process of extraction, the difference in environmental temperature and the solubilisation method used to extract the collagen.
The yield of collagen by the different acid (HCl, citric acid, acetic acid) is dependent on the reaction time. The longer the period of solubilisation, the greater the yield of collagen being extracted. For example, Skierka [82], concluded that during a 24 hour of collagen extraction in acid, about 33% of collagen was solubilised, and after 72 hours, about twice as much collagen was solubilised.
The solubility of collagen in acids depends up the enzyme concentration. A low concentration of enzyme with an acid can completely solubilise collagen; however, it will also depend on the type of acid. For example, enzyme concentration on the solubility of collagen in citric acid and HCl gave a maximum yield of 75% for citric acid and 85% for HCl [82].
Acids such as acetic acid, citric acid and hydrochloric acid (HCl) of low concentration can be added to collagen-containing samples. Acids at a pH of 2–3 and a concentration of approximately 0.5 mol/L can be used to solubilise collagen. In acid extraction of collagen, the acids swell collagen, disrupting the hydrophobic and electrostatic interactions between the tropocollagen units, and release the acid-soluble collagen (ASC). Yang et al. [80] concluded that citric acid has the best effect to extract collagen, second being acetic acid and last being hydrochloric acid. However, according to Skierka [82] and Higham [83], the most effective acid for collagen solubilisation was acetic acid and the least effective solvent was HCl. In order to achieve a sound conclusion, experiments need to be carried out to investigate the solubilisation efficiencies of each acid.
The acid molecules disrupt the collagen cross-linking in order to solubilise the collagen by allowing ligand substitution for each peptide side chain, causing disassociation of the cross-link. Thus, swelling the collagen and solubilising it out of the tissue and into solution [73].
The acid method is seen to be corrosive to the experimental equipment in terms of large-scale production. However, using a low concentration of acid in combination with an enzyme will avoid equipment corrosion and achieve a high yield product (Table 7).
The enzyme method is seen to be as the ideal method of collagen extraction. The three commonly used enzymes for collagen extraction are pepsin, papain and tryptase [80]. The enzyme acts on the non-helical peptide chains of the collagen protein, having no effect on the helix peptide chains of the collagen protein. The enzyme has better reaction selectivity and it is less destructive to the collagen protein, resulting in a protein whose triple helix structure is better preserved. Thus, the extracted collagen will have a better purity, and retain stable physical and chemical properties. The enzyme method also provides mild reaction conditions that avoid equipment corrosion and less energy consumption. However, reaction time may be long, depending on the type of enzyme used [89].
The enzyme solubilisation method works by disrupting the cross-linking that occurs in collagen. The chosen enzyme cleaves to the amino telopeptides from the tropocollagen molecule thus disrupting the cross-linking and allowing solubilisation of the collagen molecule. Enzyme solubilisation is mostly required when extracting collagen from mature tissue, this is due to the cross-links forming keto-imines which are increasingly difficult to disrupt as they contain strong intermolecular bonds. However, the enzyme method has the disadvantage of not only breaking the collagen molecule but also resulting in the scission of other proteins may occur too, hence, causing protein contamination as a result [83]. Enzymes have been used in collagen extraction, McClain et al. [78] used papain at 0.1% in buffers containing 0.02 M phosphate and 0.003 M EDTA as a solubilisation method for collagen.
The enzyme method is usually combined with the acid method to enhance the extraction process (Table 8).
The enzyme-acid solubilisation method is seen to be the most effective way to extract collagen. Both acids (citric acid, hydrochloric acid, acetic acid) and enzymes have the capability to disrupt the cross-links in a collagen molecule and make collagen soluble in solution. Addition of both an acid and an enzyme speed up the reaction time and results in a collagen protein well-kept in its triple helix structure [80]. Concentration and acid/enzyme type greatly depend on the collagen tissue and method optimization.
Dialysis is a preferred method of purification for collagen extraction, however, scaling up this technique for commercialisation has proven to be difficult. Dialysis tubes are utilised with different cut off molecular weights to separate pure collagen from other solvents, salts and enzymes and other impurities.
Ultrafiltration can be applied to remove the non-collagenous material prior to lyophilisation of collagen. Ultrafiltration utilises positive pressure to force a liquid through a semi-permeable membrane to separate species in an aqueous solution by molecular size, shape or charge. Ultrafiltration has the advantages of having a high throughput, cost-effective and large-scale purification is possible without being limited to lab-scale purification by dialysis.
Ultrafiltration enables the removal of solvents and salts of lower molecular weight from a solution (permeate). Thus, this results in the enrichment of the retained molecule (pure collagen). Ultrafiltration membranes can retain molecules in the range of 10 kDa to 1 MDa, thus concentration and purification of collagen (300 kDa) can be successfully achieved through this process.
Crossflow/tangential flow filtration: the incoming feed passes parallel across the surface of a semi-permeable membrane. A permeate and a retentate stream are generated, where the permeate is the portion of the fluid that passes through the membrane and the remainder of the feed stream, which does not pass through the cross-flow membrane, is known as the retentate stream.
Dead-end filtration: The feed moves towards the filter membrane. The particles that can be filtered are settled on the filter surface, however, this type of filtration is not sustainable as the accumulated solids need to be removed periodically or the filter needs to be replaced.
In order to preserve extracted collagen, it is usually freeze-dried and stored at conditions not exceeding −4°C. However, some researchers use hydrogen peroxide (0.3–3%) to disinfect collagen after extraction especially from fish sources.
The popularity of collagen extraction continues to increase due to many reasons. It is a high strength protein, bio-derived, has excellent biocompatibility, biodegradability, and has weak antigenicity. Another main reason that relates to waste valorisation and sustainability is the fact that collagen can be extracted from almost any mammalian skin, bones, cartilage, fish skin and even chicken feet. Most often, the meat industry results in these by-products that can end up in landfill. These advantageous characteristics have made collagen one of the most useful biomaterials.
Research to this day is being carried out to improve extraction methods in terms of efficiency and economics. In addition to improving extraction methodologies, research is being carried out on collagen to enhance its use in several industries (Table 9).
Period | Collagen extraction research |
---|---|
| |
| |
| |
| |
Method optimization and comparison of different acids and enzymes for extraction efficiency had started in this period, due to a high demand for collagen from various markets. | |
|
Timeline of advancements in collagen extraction (1960s – 2015).
There are at least 27 collagen types with 42 distinct polypeptide chains identified. Types I to XXVII collagen are fibril-forming collagens, containing triple-helix structures that can bundle into fibrils. Some collagen types are only present in certain tissues, for example, collagen types II, IX and XI are mostly found in cartilage tissues. Collagen types I to III are the ones mostly present in all collagen-containing tissues, type I being mainly present in skin tissue. Collagen characterisation is carried out to acquire information on structure, denaturation temperature, quantity, quality, thermal stability and fibril arrangement. Understanding the properties of each type of collagen will result in a better picture of what applications it can further be applied in.
The properties of the extracted collagen can be characterised by Sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE), Fourier transform infrared spectroscopy (FTIR), thermal stability (thermogravimetric analysis (TGA), differential scanning calorimetry (DSC)), morphology analysis, such as scanning electron microscopy (SEM) and transmission electron microscopy (TEM); collagen moisture content, and hydroxyproline analysis.
The results from these analyses can be compared to standard collagen found in the market to compare yields and quality. The investigation of physiochemical properties of collagen through these characterisation methods is a way of optimising future collagen extraction methods.
SDS-PAGE analysis can be used to differentiate between the different collagen types and their individual chains. SDS-PAGE patterns of the extracted collagen can be obtained through any electrophoresis device such as the Mini-Protean or a PhastGel system. The collagen sample is boiled in SDS, resulting in collagen to break down into its polypeptide chains so that the α and β components of the collagen molecule can be analysed.
Though SDS electrophoresis has been utilised for preparative separation of collagen [125], it has been mainly used to compare collagen from different tissue types and to identify collagen types and polypeptide chains. Wu et al. [126] extracted bovine collagen and applied SDS-PAGE to identify the different collagen types present.
In order to assess the collagen for abnormal formation and organisation and changes in its secondary structure, Fourier Transform Infrared Spectroscopy (FTIR) can be applied to reveal the collagen bio-distribution. FTIR has been used to study collagen denaturation [127], collagen cross-linking [128], and thermal self-assembly [129].
The vibrational bands characteristic of peptide groups and side chains provide information on protein structures. Spectral changes in amide A, amide I (1636–1661 cm−1), amide II (1549–1558 cm−1), and amide III (1200–1300 cm−1) regions are indicative of changes in collagen secondary structure [127]. An increase in the intensity of amide III and broadening of amide I are related with increased intermolecular interactions via hydrogen bonding in collagen. Among these, the amide I band (peptide bond C=O stretch) is especially sensitive to secondary structures. A reduction in the intensity of amide A, I, II and III peaks and narrowing of amide I band are associated with collagen denaturation (Td) [127].
An FT-IR spectrophotometer can be used to obtain a spectrum for collagen. Approximately 2–4 mg of collagen in 100 mg potassium bromide (kBr) can be used to obtain spectra from 4000 to 1000 cm−1.
Hydroxyproline is an amino acid found in collagen, comprising about 13% of the collagen molecule, this amino acid is not found in any other proteins apart from elastin. Thus, determining the hydroxyproline content in a specified tissue enables the calculation of the total amount of collagen present. Experimentally, the amount of hydroxyproline content in a sample for mammals [130] is multiplied by 7.46 to give the amount of collagen in the sample.
Many studies on collagen extraction have applied hydroxyproline analysis to calculate collagen content [81, 87, 131, 132]. Researchers have developed methods to effectively measure hydroxyproline concentration of collagen using calorimetric assays [19, 133], high-performance liquid chromatography, and enzymatic methods [133]. Calorimetric methods usually require complete hydrolysis of collagen to its individual amino acids, oxidising hydroxyproline present to a pyrrole, and then reacting the pyrrole with a colour forming agent. This colour change is measured using a UV/Vis spectrophotometer and compared against calibration data to determine hydroxyproline concentration [19]. To obtain the amount of collagen in a sample for mammals, the amount of hydroxyproline in the sample (mg) is multiplied by a factor of 7.46 [67].
Any DSC calorimeter brand can be used, such as a Perkin Elmer DSC7. The thermal behaviour; stability of the native molecular structure and denaturation of collagen can be determined by carrying out differential scanning calorimetry (DSC). Denaturation temperature is obtained from the transition in the baseline in the 30–80°C region by taking the inflexion point reading. Total denaturation enthalpy (∆H) can be estimated by measuring the area in the DSC thermogram.
Collagen denaturation temperature (Td) depends on collagen water content, collagen extraction method, collagen source, degree of collagen cross-linking and hydroxyproline content. Thermal stability of the collagen triple helix depends on hydrogen bonds (inter- and intra-hydrogen bonding) which further influences the folding and unfolding process when hydrogen bonds are broken and connected [134, 135]. Hence, the thermal stability of collagen depends on the cross-linking of collagen molecules (inter and intra).
Due to the polymeric nature of collagen, the thermal-induced denaturation of collagen is usually complicated. Heating collagen in wet or dry state reveals a series of thermal transitions. Thermal denaturation of collagen occurs due to hydrogen bonds breaking and hence the unfolding of the triple helices forming random polypeptide coils [136]. Cross-linking among the collagen molecules increase and mature with age and provides further stability. The age-related accumulation of cross-links increases the thermodynamic stability of collagen by increasing the activation energy required for collagen denaturation. However, the maturity of collagen cross-linking is limited to the functionality of the tissue. Post-mortem cross-linking of collagen can increase to the point where the tissue may become brittle [137].
Within the collagen fibril, there are complex interactions within and between the packed molecules. In addition to inter, intramolecular cross-links, and different forms of cross-linkages, there are several additional hydrophobic and ionic interactions that must be accounted for regarding collagen denaturation. The presence of non-collagenous components in the extracted collagen sample can cause variations in thermal denaturation [138].
Due to the domain structure of the triple helix, not all parts of the collagen molecule may denature at the same rate and it is almost impossible to define a definite equilibrium Td. Studies have also shown an increase in Td with an increase in hydroxyproline content [61, 139].
Thermal stability of extracted collagen is investigated using a gravimetric analyser. Approximately 5–10 mg of the sample can be used. The mass loss is recorded while the sample is heated from room temperature up to 800°C at a rate of 10°C per minute. The first derivative of percentage mass change versus temperature can also be calculated to investigate temperature regions where mass loss was occurring.
Ramanathan et al. [140] used TGA to assess the thermal stability of fish skin collagen which was extracted via acid-solubilisation. They report using samples of approximately 5 mg and heating samples at 10°C/min in the temperature range of 0–800°C. The acid-solubilised collagen showed two weight loss steps on the TGA thermogram, relating the first stage to the loss of structural and bound water and stage two to thermal degradation of the polypeptide chain. The study concluded to show that the two peaks observed on the TGA differential curve were of collagen denaturation and collagen degradation respectively.
The protein morphology of the extracted collagen can be studied using SEM. The morphology of the extracted collagen can be compared to the standard bovine collagen available in the market. The expected microstructure of collagen from SEM images would be to observe collagen sheets which would be a combination of collagen fibrils and fibres that are bundled together to form a fibril network and dense sheet-like structure.
Ramanathan et al. [140] used SEM to observe the surface morphologies of freeze-dried acid-solubilised fish skin collagen. The images showed a smooth surface texture, in two of the images, a layer-by-layer structure was observed (no definite fibres), and this was related to the intertwining of collagen fibres. Similarly, Rizk et al. [14], Tziveleka et al. [141], Rodrigues et al. [142], Pal et al. [139] all carried out SEM to assess the surface morphology of extracted collagen and all showed SEM images to have smooth or slightly wrinkled surfaces or sheet-like structures (Figure 8).
SEM images of extracted collagen, with 1) acid-soluble collagen of Catla fish (a), pepsin-soluble collagen of Catla fish (B), acid-soluble collagen of Rohu fish (C) and pepsin-soluble collagen of Rohu fish (D) [
Transmission electron microscopy is usually carried out to observe collagen fibril structure and it is uniformity in a much deeper level. SEM only provides limited information on collagen morphology. Figure 8 is showing an electron transmission image of mammalian lung tissue collagen at a magnification of 50 nm, while is showing a TEM image of collagen fibrils and fibres.
The preparative steps of collagen TEM are very specific and usually requires a technician to carry out each step carefully in order to observe the fibrillar structure of collagen. The Karnovsky fixative is mostly used as a preparative method prior to taking TEM images.
Collagen has risen its rank to be an integral material and an element of importance both in biomedical and non-biomedical sectors. In conclusion, research has shown that collagen can be effectively extracted from bovine and cattle hides. Using waste valorization concepts, collagen containing waste materials can be utilized to derive high-value products.
In line with the Principles of Transparency and Best Practice in Scholarly Publishing, below is a more detailed description of IntechOpen's Advertising Policy.
",metaTitle:"Advertising Policy",metaDescription:"IntechOpen partners with third-party companies to serve ads and/or collect certain information when you visit our website. These companies may collect non-personally identifiable information (not including your name, address, email address or telephone number) during your visit to IntechOpen's website.",metaKeywords:null,canonicalURL:"/page/advertising-policy",contentRaw:'[{"type":"htmlEditorComponent","content":"1. IntechOpen partners with third-party companies to serve ads and/or collect certain information when you visit our website. These companies may collect non-personally identifiable information (not including your name, address, email address or telephone number) during your visit to IntechOpen's website.
\\n\\n2. All advertisements and commercially sponsored publications are independent from editorial decisions.
\\n\\n3. IntechOpen does not endorse any product or service marked as an advertisement on IntechOpen website.
\\n\\n4. IntechOpen has blocked all the inappropriate types of advertising.
\\n\\n5. IntechOpen has blocked advertisement of harmful products or services.
\\n\\n6. Advertisements and editorial content are clearly distinguishable.
\\n\\n7. Editorial decisions will not be influenced by current or potential advertisers and will not be influenced by marketing decisions.
\\n\\n8. Advertisers have no control or influence over the results of searches a user may conduct on the website by keyword or topic search.
\\n\\n9. Types of advertisments:
\\n\\n- Advertisements in the Physical Sciences, Engineering and Technology, and Social Sciences and Humanities sections of the IntechOpen website are programmatic (based on user behaviour such as web pages visited, content viewed, etc.)
\\n\\n- Advertisements in the Life Sciences and Health Sciences sections of the IntechOpen website are programmatic as well as contextual based on the content of the respective books and chapters. IntechOpen's third party partner eHealthcare Solutions (EHS) is a unique marketing platform that specializes in connecting niche audiences with healthcare brands.
\\n\\nYou may view their privacy policy here: https://ehealthcaresolutions.com/privacy-policy/
\\n\\n10. IntechOpen Advertising Sales department makes the decisions about the types of advertisements to include or exclude. Placement of advertising is at the discretion of IntechOpen. IntechOpen retains the right to reject and/or request modifications to the advertisement. An advertisement that is visible online, will be withdrawn from the site at any time if the Editor(s) or Author(s) request its removal.
\\n\\n11. Users can make decisions about accepting advertisements. Users can block all the advertisements by using ad blockers. Users can send all the complaints about advertising to: info@intechopen.com.
\\n\\nPolicy last updated: 2021-04-28
\\n"}]'},components:[{type:"htmlEditorComponent",content:'1. IntechOpen partners with third-party companies to serve ads and/or collect certain information when you visit our website. These companies may collect non-personally identifiable information (not including your name, address, email address or telephone number) during your visit to IntechOpen's website.
\n\n2. All advertisements and commercially sponsored publications are independent from editorial decisions.
\n\n3. IntechOpen does not endorse any product or service marked as an advertisement on IntechOpen website.
\n\n4. IntechOpen has blocked all the inappropriate types of advertising.
\n\n5. IntechOpen has blocked advertisement of harmful products or services.
\n\n6. Advertisements and editorial content are clearly distinguishable.
\n\n7. Editorial decisions will not be influenced by current or potential advertisers and will not be influenced by marketing decisions.
\n\n8. Advertisers have no control or influence over the results of searches a user may conduct on the website by keyword or topic search.
\n\n9. Types of advertisments:
\n\n- Advertisements in the Physical Sciences, Engineering and Technology, and Social Sciences and Humanities sections of the IntechOpen website are programmatic (based on user behaviour such as web pages visited, content viewed, etc.)
\n\n- Advertisements in the Life Sciences and Health Sciences sections of the IntechOpen website are programmatic as well as contextual based on the content of the respective books and chapters. IntechOpen's third party partner eHealthcare Solutions (EHS) is a unique marketing platform that specializes in connecting niche audiences with healthcare brands.
\n\nYou may view their privacy policy here: https://ehealthcaresolutions.com/privacy-policy/
\n\n10. IntechOpen Advertising Sales department makes the decisions about the types of advertisements to include or exclude. Placement of advertising is at the discretion of IntechOpen. IntechOpen retains the right to reject and/or request modifications to the advertisement. An advertisement that is visible online, will be withdrawn from the site at any time if the Editor(s) or Author(s) request its removal.
\n\n11. Users can make decisions about accepting advertisements. Users can block all the advertisements by using ad blockers. Users can send all the complaints about advertising to: info@intechopen.com.
\n\nPolicy last updated: 2021-04-28
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{sort:"featured,name"},profiles:[],filtersByRegion:[],offset:0,limit:12,total:null},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"1",sort:"dateEndThirdStepPublish",src:"EDCMP",topicId:"12"},books:[{type:"book",id:"11650",title:"Aquifers",subtitle:null,isOpenForSubmission:!0,hash:"2a7acb5c7fbf3f244aefa79513407b5e",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11650.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12130",title:"Sustainable Built Environment",subtitle:null,isOpenForSubmission:!0,hash:"ed1dbae71b967e06efb049208f0c1068",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12130.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12131",title:"Climate Change and Fires",subtitle:null,isOpenForSubmission:!0,hash:"ea0858f07a3e87aaf9e5eaa75b4b44bd",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12131.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12221",title:"Air Pollution",subtitle:null,isOpenForSubmission:!0,hash:"439a018ee0c4960560cb798601f2a372",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12221.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12222",title:"Microplastics",subtitle:null,isOpenForSubmission:!0,hash:"b9e8b19ba1ae8e03753638b27ff1efdc",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12222.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12224",title:"Mangrove Ecosystem",subtitle:null,isOpenForSubmission:!0,hash:"de7cd5453d6177a68cfd1c3bcc073bc7",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12224.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12180",title:"Wetlands",subtitle:null,isOpenForSubmission:!0,hash:"8957c5c2baaed32223f911a6d4aa5a03",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12180.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:39},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:11},{group:"topic",caption:"Business, Management and Economics",value:7,count:7},{group:"topic",caption:"Chemistry",value:8,count:17},{group:"topic",caption:"Computer and Information Science",value:9,count:16},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:15},{group:"topic",caption:"Engineering",value:11,count:32},{group:"topic",caption:"Environmental Sciences",value:12,count:7},{group:"topic",caption:"Immunology and Microbiology",value:13,count:11},{group:"topic",caption:"Materials Science",value:14,count:11},{group:"topic",caption:"Mathematics",value:15,count:6},{group:"topic",caption:"Medicine",value:16,count:100},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:2},{group:"topic",caption:"Neuroscience",value:18,count:7},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:11},{group:"topic",caption:"Physics",value:20,count:2},{group:"topic",caption:"Psychology",value:21,count:7},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:32},{group:"topic",caption:"Technology",value:24,count:1}],offset:12,limit:12,total:7},popularBooks:{featuredBooks:[{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11001",title:"Density Functional Theory",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"82d53383af78ab41eb982086c02fb2bb",slug:"density-functional-theory-recent-advances-new-perspectives-and-applications",bookSignature:"Daniel Glossman-Mitnik",coverURL:"https://cdn.intechopen.com/books/images_new/11001.jpg",editors:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11752",title:"Natural Drugs from Plants",subtitle:null,isOpenForSubmission:!1,hash:"a0a83c0822608ef7592bf16a5ed0ada4",slug:"natural-drugs-from-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10584",title:"Engineered Wood Products for Construction",subtitle:null,isOpenForSubmission:!1,hash:"421757c56a3735986055250821275a51",slug:"engineered-wood-products-for-construction",bookSignature:"Meng Gong",coverURL:"https://cdn.intechopen.com/books/images_new/10584.jpg",editors:[{id:"274242",title:"Dr.",name:"Meng",middleName:null,surname:"Gong",slug:"meng-gong",fullName:"Meng Gong"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9670",title:"Current Trends in Wheat Research",subtitle:null,isOpenForSubmission:!1,hash:"89d795987f1747a76eee532700d2093d",slug:"current-trends-in-wheat-research",bookSignature:"Mahmood-ur-Rahman Ansari",coverURL:"https://cdn.intechopen.com/books/images_new/9670.jpg",editors:[{id:"185476",title:"Dr.",name:"Mahmood-ur-Rahman",middleName:null,surname:"Ansari",slug:"mahmood-ur-rahman-ansari",fullName:"Mahmood-ur-Rahman Ansari"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9032",title:"Corporate Social Responsibility",subtitle:null,isOpenForSubmission:!1,hash:"f609bf3251d7cc7bae0099a4374adfc3",slug:"corporate-social-responsibility",bookSignature:"Beatrice Orlando",coverURL:"https://cdn.intechopen.com/books/images_new/9032.jpg",editors:[{id:"232969",title:"Prof.",name:"Beatrice",middleName:null,surname:"Orlando",slug:"beatrice-orlando",fullName:"Beatrice Orlando"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10681",title:"Biodegradation Technology of Organic and Inorganic Pollutants",subtitle:null,isOpenForSubmission:!1,hash:"9a6e10e02788092872fd249436898e97",slug:"biodegradation-technology-of-organic-and-inorganic-pollutants",bookSignature:"Kassio Ferreira Mendes, Rodrigo Nogueira de Sousa and Kamila Cabral Mielke",coverURL:"https://cdn.intechopen.com/books/images_new/10681.jpg",editors:[{id:"197720",title:"Ph.D.",name:"Kassio",middleName:null,surname:"Ferreira Mendes",slug:"kassio-ferreira-mendes",fullName:"Kassio Ferreira Mendes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9808",title:"Contemporary Topics in Patient Safety",subtitle:"Volume 1",isOpenForSubmission:!1,hash:"fb6371607c2c6c02c6a2af8892765aba",slug:"contemporary-topics-in-patient-safety-volume-1",bookSignature:"Stanislaw P. Stawicki and Michael S. Firstenberg",coverURL:"https://cdn.intechopen.com/books/images_new/9808.jpg",editors:[{id:"181694",title:"Dr.",name:"Stanislaw P.",middleName:null,surname:"Stawicki",slug:"stanislaw-p.-stawicki",fullName:"Stanislaw P. Stawicki"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9544",title:"Global Trade in the Emerging Business Environment",subtitle:null,isOpenForSubmission:!1,hash:"fb8cb09b9599246add78d508a98273d5",slug:"global-trade-in-the-emerging-business-environment",bookSignature:"Muhammad Mohiuddin, Jingbin Wang , Md. Samim Al Azad and Selim Ahmed",coverURL:"https://cdn.intechopen.com/books/images_new/9544.jpg",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4380},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",publishedDate:"May 18th 2022",numberOfDownloads:3385,editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11001",title:"Density Functional Theory",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"82d53383af78ab41eb982086c02fb2bb",slug:"density-functional-theory-recent-advances-new-perspectives-and-applications",bookSignature:"Daniel Glossman-Mitnik",coverURL:"https://cdn.intechopen.com/books/images_new/11001.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1875,editors:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",publishedDate:"May 11th 2022",numberOfDownloads:3842,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11752",title:"Natural Drugs from Plants",subtitle:null,isOpenForSubmission:!1,hash:"a0a83c0822608ef7592bf16a5ed0ada4",slug:"natural-drugs-from-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",publishedDate:"May 11th 2022",numberOfDownloads:3008,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1109,editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1010,editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10584",title:"Engineered Wood Products for Construction",subtitle:null,isOpenForSubmission:!1,hash:"421757c56a3735986055250821275a51",slug:"engineered-wood-products-for-construction",bookSignature:"Meng Gong",coverURL:"https://cdn.intechopen.com/books/images_new/10584.jpg",publishedDate:"April 28th 2022",numberOfDownloads:3918,editors:[{id:"274242",title:"Dr.",name:"Meng",middleName:null,surname:"Gong",slug:"meng-gong",fullName:"Meng Gong"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9670",title:"Current Trends in Wheat Research",subtitle:null,isOpenForSubmission:!1,hash:"89d795987f1747a76eee532700d2093d",slug:"current-trends-in-wheat-research",bookSignature:"Mahmood-ur-Rahman Ansari",coverURL:"https://cdn.intechopen.com/books/images_new/9670.jpg",publishedDate:"May 11th 2022",numberOfDownloads:1654,editors:[{id:"185476",title:"Dr.",name:"Mahmood-ur-Rahman",middleName:null,surname:"Ansari",slug:"mahmood-ur-rahman-ansari",fullName:"Mahmood-ur-Rahman Ansari"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9032",title:"Corporate Social Responsibility",subtitle:null,isOpenForSubmission:!1,hash:"f609bf3251d7cc7bae0099a4374adfc3",slug:"corporate-social-responsibility",bookSignature:"Beatrice Orlando",coverURL:"https://cdn.intechopen.com/books/images_new/9032.jpg",publishedDate:"March 16th 2022",numberOfDownloads:7686,editors:[{id:"232969",title:"Prof.",name:"Beatrice",middleName:null,surname:"Orlando",slug:"beatrice-orlando",fullName:"Beatrice Orlando"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10681",title:"Biodegradation Technology of Organic and Inorganic Pollutants",subtitle:null,isOpenForSubmission:!1,hash:"9a6e10e02788092872fd249436898e97",slug:"biodegradation-technology-of-organic-and-inorganic-pollutants",bookSignature:"Kassio Ferreira Mendes, Rodrigo Nogueira de Sousa and Kamila Cabral Mielke",coverURL:"https://cdn.intechopen.com/books/images_new/10681.jpg",publishedDate:"April 20th 2022",numberOfDownloads:3444,editors:[{id:"197720",title:"Ph.D.",name:"Kassio",middleName:null,surname:"Ferreira Mendes",slug:"kassio-ferreira-mendes",fullName:"Kassio Ferreira Mendes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10871",title:"Computed-Tomography (CT) Scan",subtitle:null,isOpenForSubmission:!1,hash:"966d8cf74fa27eea1b9cbc9a6ee94993",slug:"computed-tomography-ct-scan",bookSignature:"Reda R. Gharieb",coverURL:"https://cdn.intechopen.com/books/images_new/10871.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. Gharieb"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10654",title:"Brain-Computer Interface",subtitle:null,isOpenForSubmission:!1,hash:"a5308884068cc53ed31c6baba756857f",slug:"brain-computer-interface",bookSignature:"Vahid Asadpour",coverURL:"https://cdn.intechopen.com/books/images_new/10654.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11196",title:"New Updates in E-Learning",subtitle:null,isOpenForSubmission:!1,hash:"6afaadf68e2a0a4b370ac5ceb5ca89c6",slug:"new-updates-in-e-learning",bookSignature:"Eduard Babulak",coverURL:"https://cdn.intechopen.com/books/images_new/11196.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"10086",title:"Prof.",name:"Eduard",middleName:null,surname:"Babulak",slug:"eduard-babulak",fullName:"Eduard Babulak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"620",title:"Graphical User Interface",slug:"graphical-user-interface",parent:{id:"97",title:"Web Engineering",slug:"web-engineering"},numberOfBooks:1,numberOfSeries:0,numberOfAuthorsAndEditors:1,numberOfWosCitations:40,numberOfCrossrefCitations:51,numberOfDimensionsCitations:70,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"620",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"6115",title:"User Interfaces",subtitle:null,isOpenForSubmission:!1,hash:"45c87e29ae44f3be2cc9ae8bc0b33acd",slug:"user-interfaces",bookSignature:"Rita Matrai",coverURL:"https://cdn.intechopen.com/books/images_new/6115.jpg",editedByType:"Edited by",editors:[{id:"7308",title:"PhD.",name:"Rita",middleName:null,surname:"Mátrai",slug:"rita-matrai",fullName:"Rita Mátrai"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:1,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"10814",doi:"10.5772/9500",title:"Simple but Crucial User Interfaces in the World Wide Web: Introducing 20 Guidelines for Usable Web Form Design",slug:"simple-but-crucial-user-interfaces-in-the-world-wide-web-introducing-20-guidelines-for-usable-web-fo",totalDownloads:4401,totalCrossrefCites:26,totalDimensionsCites:37,abstract:null,book:{id:"6115",slug:"user-interfaces",title:"User Interfaces",fullTitle:"User Interfaces"},signatures:"J.A. Bargas-Avila, O. Brenzikofer, S.P. Roth, A.N. Tuch, S. Orsini and K. Opwis",authors:null},{id:"10803",doi:"10.5772/8903",title:"Considering the Importance of User Profiles in Interface Design",slug:"considering-the-importance-of-user-profiles-in-interface-design",totalDownloads:7424,totalCrossrefCites:5,totalDimensionsCites:9,abstract:null,book:{id:"6115",slug:"user-interfaces",title:"User Interfaces",fullTitle:"User Interfaces"},signatures:"Yuanhua Liu, Anna-Lisa Osvalder and MariAnne Karlsson",authors:null},{id:"10804",doi:"10.5772/9490",title:"An Empirical Approach for the Evaluation of Voice User Interfaces",slug:"an-empirical-approach-for-the-evaluation-of-voice-user-interfaces",totalDownloads:2461,totalCrossrefCites:8,totalDimensionsCites:8,abstract:null,book:{id:"6115",slug:"user-interfaces",title:"User Interfaces",fullTitle:"User Interfaces"},signatures:"Valeria Farinazzo, Martins Salvador, Andre Luiz S. Kawamoto and Joao Soares de Oliveira Neto",authors:null},{id:"10813",doi:"10.5772/9499",title:"Multimodal Interfaces to Mobile Terminals – A Design-For-All Approach",slug:"multimodal-interfaces-to-mobile-terminals-a-design-for-all-approach",totalDownloads:2575,totalCrossrefCites:2,totalDimensionsCites:3,abstract:null,book:{id:"6115",slug:"user-interfaces",title:"User Interfaces",fullTitle:"User Interfaces"},signatures:"Knut Kvale and Narada Dilp Warakagoda",authors:null},{id:"10812",doi:"10.5772/9498",title:"Automatic Generation of User Interface Models and Prototypes from Domain and Use Case Models",slug:"automatic-generation-of-user-interface-models-and-prototypes-from-domain-and-use-case-models",totalDownloads:3619,totalCrossrefCites:3,totalDimensionsCites:3,abstract:null,book:{id:"6115",slug:"user-interfaces",title:"User Interfaces",fullTitle:"User Interfaces"},signatures:"Antonio Miguel Rosado da Cruz and Joao Pascoal Faria",authors:null}],mostDownloadedChaptersLast30Days:[{id:"10806",title:"Automatic Hand-Pose Trajectory Tracking System Using Video Sequences",slug:"automatic-hand-pose-trajectory-tracking-system-using-video-sequences",totalDownloads:2687,totalCrossrefCites:2,totalDimensionsCites:2,abstract:null,book:{id:"6115",slug:"user-interfaces",title:"User Interfaces",fullTitle:"User Interfaces"},signatures:"Yuan-Hsiang Chang and Chen-Ming Chang",authors:null},{id:"10809",title:"Understanding SOA Perspective of e-Governance in Indian Context: Case Based Study",slug:"understanding-soa-perspective-of-e-governance-in-indian-context-case-based-study",totalDownloads:3989,totalCrossrefCites:1,totalDimensionsCites:2,abstract:null,book:{id:"6115",slug:"user-interfaces",title:"User Interfaces",fullTitle:"User Interfaces"},signatures:"Harekrishna Misra",authors:null},{id:"10814",title:"Simple but Crucial User Interfaces in the World Wide Web: Introducing 20 Guidelines for Usable Web Form Design",slug:"simple-but-crucial-user-interfaces-in-the-world-wide-web-introducing-20-guidelines-for-usable-web-fo",totalDownloads:4401,totalCrossrefCites:26,totalDimensionsCites:37,abstract:null,book:{id:"6115",slug:"user-interfaces",title:"User Interfaces",fullTitle:"User Interfaces"},signatures:"J.A. Bargas-Avila, O. Brenzikofer, S.P. Roth, A.N. Tuch, S. Orsini and K. Opwis",authors:null},{id:"10816",title:"Embedded User Interface for Mobile Applications to Satisfy Design for All Principles",slug:"embedded-user-interface-for-mobile-applications-to-satisfy-design-for-all-principles",totalDownloads:4476,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"6115",slug:"user-interfaces",title:"User Interfaces",fullTitle:"User Interfaces"},signatures:"Evangelos Bekiaris, Maria Gemou and Kostantinos Kalogirou",authors:null},{id:"10803",title:"Considering the Importance of User Profiles in Interface Design",slug:"considering-the-importance-of-user-profiles-in-interface-design",totalDownloads:7424,totalCrossrefCites:5,totalDimensionsCites:9,abstract:null,book:{id:"6115",slug:"user-interfaces",title:"User Interfaces",fullTitle:"User Interfaces"},signatures:"Yuanhua Liu, Anna-Lisa Osvalder and MariAnne Karlsson",authors:null}],onlineFirstChaptersFilter:{topicId:"620",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:288,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188",scope:"This series will provide a comprehensive overview of recent research trends in various Infectious Diseases (as per the most recent Baltimore classification). Topics will include general overviews of infections, immunopathology, diagnosis, treatment, epidemiology, etiology, and current clinical recommendations for managing infectious diseases. Ongoing issues, recent advances, and future diagnostic approaches and therapeutic strategies will also be discussed. This book series will focus on various aspects and properties of infectious diseases whose deep understanding is essential for safeguarding the human race from losing resources and economies due to pathogens.",coverUrl:"https://cdn.intechopen.com/series/covers/6.jpg",latestPublicationDate:"May 19th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:13,editor:{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},editorTwo:null,editorThree:null},subseries:{paginationCount:5,paginationItems:[{id:"19",title:"Animal Science",coverUrl:"https://cdn.intechopen.com/series_topics/covers/19.jpg",editor:{id:"259298",title:"Dr.",name:"Edward",middleName:null,surname:"Narayan",slug:"edward-narayan",fullName:"Edward Narayan",profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",biography:"Dr. Edward Narayan graduated with Ph.D. degree in Biology from the University of the South Pacific and pioneered non-invasive reproductive and stress endocrinology tools for amphibians - the novel development and validation of non-invasive enzyme immunoassays for the evaluation of reproductive hormonal cycle and stress hormone responses to environmental stressors. \nDr. Narayan leads the Stress Lab (Comparative Physiology and Endocrinology) at the University of Queensland. A dynamic career research platform which is based on the thematic areas of comparative vertebrate physiology, stress endocrinology, reproductive endocrinology, animal health and welfare, and conservation biology. \nEdward has supervised 40 research students and published over 60 peer reviewed research.",institutionString:null,institution:{name:"University of Queensland",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"258334",title:"Dr.",name:"Carlos Eduardo",middleName:null,surname:"Fonseca-Alves",slug:"carlos-eduardo-fonseca-alves",fullName:"Carlos Eduardo Fonseca-Alves",profilePictureURL:"https://mts.intechopen.com/storage/users/258334/images/system/258334.jpg",institutionString:null,institution:{name:"Universidade Paulista",institutionURL:null,country:{name:"Brazil"}}},{id:"191123",title:"Dr.",name:"Juan José",middleName:null,surname:"Valdez-Alarcón",slug:"juan-jose-valdez-alarcon",fullName:"Juan José Valdez-Alarcón",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBfcQAG/Profile_Picture_1631354558068",institutionString:"Universidad Michoacana de San Nicolás de Hidalgo",institution:{name:"Universidad Michoacana de San Nicolás de Hidalgo",institutionURL:null,country:{name:"Mexico"}}},{id:"161556",title:"Dr.",name:"Maria Dos Anjos",middleName:null,surname:"Pires",slug:"maria-dos-anjos-pires",fullName:"Maria Dos Anjos Pires",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS8q2QAC/Profile_Picture_1633432838418",institutionString:null,institution:{name:"University of Trás-os-Montes and Alto Douro",institutionURL:null,country:{name:"Portugal"}}},{id:"209839",title:"Dr.",name:"Marina",middleName:null,surname:"Spinu",slug:"marina-spinu",fullName:"Marina Spinu",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRLXpQAO/Profile_Picture_1630044895475",institutionString:null,institution:{name:"University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca",institutionURL:null,country:{name:"Romania"}}},{id:"92185",title:"Dr.",name:"Sara",middleName:null,surname:"Savic",slug:"sara-savic",fullName:"Sara Savic",profilePictureURL:"https://mts.intechopen.com/storage/users/92185/images/system/92185.jfif",institutionString:'Scientific Veterinary Institute "Novi Sad"',institution:{name:'Scientific Veterinary Institute "Novi Sad"',institutionURL:null,country:{name:"Serbia"}}}]},{id:"20",title:"Animal Nutrition",coverUrl:"https://cdn.intechopen.com/series_topics/covers/20.jpg",editor:{id:"175967",title:"Dr.",name:"Manuel",middleName:null,surname:"Gonzalez Ronquillo",slug:"manuel-gonzalez-ronquillo",fullName:"Manuel Gonzalez Ronquillo",profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",biography:"Dr. Manuel González Ronquillo obtained his doctorate degree from the University of Zaragoza, Spain, in 2001. He is a research professor at the Faculty of Veterinary Medicine and Animal Husbandry, Autonomous University of the State of Mexico. He is also a level-2 researcher. He received a Fulbright-Garcia Robles fellowship for a postdoctoral stay at the US Dairy Forage Research Center, Madison, Wisconsin, USA in 2008–2009. He received grants from Alianza del Pacifico for a stay at the University of Magallanes, Chile, in 2014, and from Consejo Nacional de Ciencia y Tecnología (CONACyT) to work in the Food and Agriculture Organization’s Animal Production and Health Division (AGA), Rome, Italy, in 2014–2015. He has collaborated with researchers from different countries and published ninety-eight journal articles. He teaches various degree courses in zootechnics, sheep production, and agricultural sciences and natural resources.\n\nDr. Ronquillo’s research focuses on the evaluation of sustainable animal diets (StAnD), using native resources of the region, decreasing carbon footprint, and applying meta-analysis and mathematical models for a better understanding of animal production.",institutionString:null,institution:{name:"Universidad Autónoma del Estado de México",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"175762",title:"Dr.",name:"Alfredo J.",middleName:null,surname:"Escribano",slug:"alfredo-j.-escribano",fullName:"Alfredo J. Escribano",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRGnzQAG/Profile_Picture_1633076636544",institutionString:"Consultant and Independent Researcher in Industry Sector, Spain",institution:null},{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra",profilePictureURL:"https://mts.intechopen.com/storage/users/310962/images/system/310962.jpg",institutionString:null,institution:{name:"West Bengal University of Animal and Fishery Sciences",institutionURL:null,country:{name:"India"}}},{id:"216995",title:"Prof.",name:"Figen",middleName:null,surname:"Kırkpınar",slug:"figen-kirkpinar",fullName:"Figen Kırkpınar",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRMzxQAG/Profile_Picture_1625722918145",institutionString:null,institution:{name:"Ege University",institutionURL:null,country:{name:"Turkey"}}}]},{id:"28",title:"Animal Reproductive Biology and Technology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/28.jpg",editor:{id:"177225",title:"Prof.",name:"Rosa Maria Lino Neto",middleName:null,surname:"Pereira",slug:"rosa-maria-lino-neto-pereira",fullName:"Rosa Maria Lino Neto Pereira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9wkQAC/Profile_Picture_1624519982291",biography:"Rosa Maria Lino Neto Pereira (DVM, MsC, PhD and) is currently a researcher at the Genetic Resources and Biotechnology Unit of the National Institute of Agrarian and Veterinarian Research (INIAV, Portugal). She is the head of the Reproduction and Embryology Laboratories and was lecturer of Reproduction and Reproductive Biotechnologies at Veterinary Medicine Faculty. She has over 25 years of experience working in reproductive biology and biotechnology areas with a special emphasis on embryo and gamete cryopreservation, for research and animal genetic resources conservation, leading research projects with several peer-reviewed papers. Rosa Pereira is member of the ERFP-FAO Ex situ Working Group and of the Management Commission of the Portuguese Animal Germplasm Bank.",institutionString:"The National Institute for Agricultural and Veterinary Research. Portugal",institution:null},editorTwo:null,editorThree:null,editorialBoard:[{id:"90066",title:"Dr.",name:"Alexandre",middleName:"Rodrigues",surname:"Silva",slug:"alexandre-silva",fullName:"Alexandre Silva",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRt8pQAC/Profile_Picture_1622531020756",institutionString:null,institution:{name:"Universidade Federal Rural do Semi-Árido",institutionURL:null,country:{name:"Brazil"}}},{id:"176987",title:"Ph.D.",name:"María-José",middleName:"Carrascosa",surname:"Argente",slug:"maria-jose-argente",fullName:"María-José Argente",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9vOQAS/Profile_Picture_1630330499537",institutionString:null,institution:{name:"Miguel Hernandez University",institutionURL:null,country:{name:"Spain"}}},{id:"321396",title:"Prof.",name:"Muhammad Subhan",middleName:null,surname:"Qureshi",slug:"muhammad-subhan-qureshi",fullName:"Muhammad Subhan Qureshi",profilePictureURL:"https://mts.intechopen.com/storage/users/321396/images/system/321396.jpg",institutionString:null,institution:{name:"University of Agriculture",institutionURL:null,country:{name:"Pakistan"}}},{id:"183723",title:"Dr.",name:"Xiaojun",middleName:null,surname:"Liu",slug:"xiaojun-liu",fullName:"Xiaojun Liu",profilePictureURL:"https://mts.intechopen.com/storage/users/183723/images/system/183723.jpg",institutionString:null,institution:null}]}]},overviewPageOFChapters:{paginationCount:1,paginationItems:[{id:"81831",title:"Deep Network Model and Regression Analysis using OLS Method for Predicting Lung Vital Capacity",doi:"10.5772/intechopen.104737",signatures:"Harun Sümbül",slug:"deep-network-model-and-regression-analysis-using-ols-method-for-predicting-lung-vital-capacity",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Decision Science - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11604.jpg",subseries:{id:"86",title:"Business and Management"}}}]},overviewPagePublishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"11392",title:"Leadership in a Changing World",subtitle:"A Multidimensional Perspective",coverURL:"https://cdn.intechopen.com/books/images_new/11392.jpg",slug:"leadership-in-a-changing-world-a-multidimensional-perspective",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Muhammad Mohiuddin, Bilal Khalid, Md. Samim Al Azad and Slimane Ed-dafali",hash:"86a6d33cf601587e591064ce92effc02",volumeInSeries:1,fullTitle:"Leadership in a Changing World - A Multidimensional Perspective",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038UqSfQAK/Profile_Picture_2022-05-13T10:39:03.jpg",biography:"Dr. Muhammad Mohiuddin is an Associate Professor of International Business at Laval University, Canada. He has taught at Thompson Rivers University, Canada; University of Paris-Est, France; Osnabruck University of Applied Science, Germany; and Shanghai Institute of Technology and Tianjin University of Technology, China. He has published research in Research Policy, Applied Economics, Review of Economic Philosophy, Strategic Change, International Journal of Logistics, Sustainability, Journal of Environmental Management, Journal of Global Information Management, Journal of Cleaner Production, M@N@GEMENT, and more. He is a member of CEDIMES Institut (France), Academy of International Business (AIB), Strategic Management Society (SMS), Academy of Management (AOM), Administrative Science Association of Canada (ASAC), and Canadian council of small business and entrepreneurship (CCSBE). He is currently the director of the Research Group on Contemporary Asia (GERAC) at Laval University. He is also co-managing editor of Transnational Corporations Review and a guest editor for Electronic Commerce Research and Journal of Internet Technology.",institutionString:"Université Laval",institution:{name:"Université Laval",institutionURL:null,country:{name:"Canada"}}}]}]},openForSubmissionBooks:{paginationCount:1,paginationItems:[{id:"11601",title:"Econometrics - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11601.jpg",hash:"bc8ab49e2cf436c217a49ca8c12a22eb",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 13th 2022",isOpenForSubmission:!0,editors:[{id:"452331",title:"Dr.",name:"Brian",surname:"Sloboda",slug:"brian-sloboda",fullName:"Brian Sloboda"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:4,paginationItems:[{id:"81821",title:"Pneumococcal Carriage in Jordanian Children and the Importance of Vaccination",doi:"10.5772/intechopen.104999",signatures:"Adnan Al-Lahham",slug:"pneumococcal-carriage-in-jordanian-children-and-the-importance-of-vaccination",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Streptococcal Infections",coverURL:"https://cdn.intechopen.com/books/images_new/10828.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}},{id:"81813",title:"Schistosomiasis: Discovery of New Molecules for Disease Treatment and Vaccine Development",doi:"10.5772/intechopen.104738",signatures:"Andressa Barban do Patrocinio",slug:"schistosomiasis-discovery-of-new-molecules-for-disease-treatment-and-vaccine-development",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"New Horizons for Schistosomiasis Research",coverURL:"https://cdn.intechopen.com/books/images_new/10829.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"81644",title:"Perspective Chapter: Ethics of Using Placebo Controlled Trials for Covid-19 Vaccine Development in Vulnerable Populations",doi:"10.5772/intechopen.104776",signatures:"Lesley Burgess, Jurie Jordaan and Matthew Wilson",slug:"perspective-chapter-ethics-of-using-placebo-controlled-trials-for-covid-19-vaccine-development-in-vu",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"80546",title:"Streptococcal Skin and Skin-Structure Infections",doi:"10.5772/intechopen.102894",signatures:"Alwyn Rapose",slug:"streptococcal-skin-and-skin-structure-infections",totalDownloads:48,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Streptococcal Infections",coverURL:"https://cdn.intechopen.com/books/images_new/10828.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}}]},subseriesFiltersForOFChapters:[{caption:"Parasitic Infectious Diseases",value:5,count:1,group:"subseries"},{caption:"Viral Infectious Diseases",value:6,count:1,group:"subseries"},{caption:"Bacterial Infectious Diseases",value:3,count:2,group:"subseries"}],publishedBooks:{paginationCount:10,paginationItems:[{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",slug:"animal-feed-science-and-nutrition-production-health-and-environment",publishedDate:"May 18th 2022",editedByType:"Edited by",bookSignature:"Amlan Kumar Patra",hash:"79944fc8fbbaa329aed6fde388154832",volumeInSeries:10,fullTitle:"Animal Feed Science and Nutrition - Production, Health and Environment",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra",profilePictureURL:"https://mts.intechopen.com/storage/users/310962/images/system/310962.jpg",institutionString:null,institution:{name:"West Bengal University of Animal and Fishery Sciences",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8737",title:"Rabies Virus at the Beginning of 21st Century",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8737.jpg",slug:"rabies-virus-at-the-beginning-of-21st-century",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Sergey Tkachev",hash:"49cce3f548da548c718c865feb343509",volumeInSeries:9,fullTitle:"Rabies Virus at the Beginning of 21st Century",editors:[{id:"61139",title:"Dr.",name:"Sergey",middleName:null,surname:"Tkachev",slug:"sergey-tkachev",fullName:"Sergey Tkachev",profilePictureURL:"https://mts.intechopen.com/storage/users/61139/images/system/61139.png",institutionString:"Russian Academy of Sciences",institution:{name:"Russian Academy of Sciences",institutionURL:null,country:{name:"Russia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10496",title:"Advanced Studies in the 21st Century Animal Nutrition",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10496.jpg",slug:"advanced-studies-in-the-21st-century-animal-nutrition",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"László Babinszky, Juliana Oliveira and Edson Mauro Santos",hash:"8ffe43a82ac48b309abc3632bbf3efd0",volumeInSeries:8,fullTitle:"Advanced Studies in the 21st Century Animal Nutrition",editors:[{id:"53998",title:"Prof.",name:"László",middleName:null,surname:"Babinszky",slug:"laszlo-babinszky",fullName:"László Babinszky",profilePictureURL:"https://mts.intechopen.com/storage/users/53998/images/system/53998.png",institutionString:"University of Debrecen",institution:{name:"University of Debrecen",institutionURL:null,country:{name:"Hungary"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10497",title:"Canine Genetics, Health and Medicine",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10497.jpg",slug:"canine-genetics-health-and-medicine",publishedDate:"June 2nd 2021",editedByType:"Edited by",bookSignature:"Catrin Rutland",hash:"b91512e31ce34032e560362e6cbccc1c",volumeInSeries:7,fullTitle:"Canine Genetics, Health and Medicine",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8545",title:"Animal Reproduction in Veterinary Medicine",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8545.jpg",slug:"animal-reproduction-in-veterinary-medicine",publishedDate:"January 20th 2021",editedByType:"Edited by",bookSignature:"Faruk Aral, Rita Payan-Carreira and Miguel Quaresma",hash:"13aaddf5fdbbc78387e77a7da2388bf6",volumeInSeries:6,fullTitle:"Animal Reproduction in Veterinary Medicine",editors:[{id:"25600",title:"Prof.",name:"Faruk",middleName:null,surname:"Aral",slug:"faruk-aral",fullName:"Faruk Aral",profilePictureURL:"https://mts.intechopen.com/storage/users/25600/images/system/25600.jpg",institutionString:"Independent Researcher",institution:{name:"Harran University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9081",title:"Equine Science",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9081.jpg",slug:"equine-science",publishedDate:"September 23rd 2020",editedByType:"Edited by",bookSignature:"Catrin Rutland and Albert Rizvanov",hash:"ac415ef2f5450fa80fdb9cf6cf32cd2d",volumeInSeries:5,fullTitle:"Equine Science",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8460",title:"Reproductive Biology and Technology in Animals",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8460.jpg",slug:"reproductive-biology-and-technology-in-animals",publishedDate:"April 15th 2020",editedByType:"Edited by",bookSignature:"Juan Carlos Gardón Poggi and Katy Satué Ambrojo",hash:"32ef5fe73998dd723d308225d756fa1e",volumeInSeries:4,fullTitle:"Reproductive Biology and Technology in Animals",editors:[{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón",slug:"juan-carlos-gardon",fullName:"Juan Carlos Gardón",profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",institutionString:"Catholic University of Valencia San Vicente Mártir, Spain",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8524",title:"Lactation in Farm Animals",subtitle:"Biology, Physiological Basis, Nutritional Requirements, and Modelization",coverURL:"https://cdn.intechopen.com/books/images_new/8524.jpg",slug:"lactation-in-farm-animals-biology-physiological-basis-nutritional-requirements-and-modelization",publishedDate:"January 22nd 2020",editedByType:"Edited by",bookSignature:"Naceur M'Hamdi",hash:"2aa2a9a0ec13040bbf0455e34625504e",volumeInSeries:3,fullTitle:"Lactation in Farm Animals - Biology, Physiological Basis, Nutritional Requirements, and Modelization",editors:[{id:"73376",title:"Dr.",name:"Naceur",middleName:null,surname:"M'Hamdi",slug:"naceur-m'hamdi",fullName:"Naceur M'Hamdi",profilePictureURL:"https://mts.intechopen.com/storage/users/73376/images/system/73376.jpg",institutionString:null,institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7144",title:"Veterinary Anatomy and Physiology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7144.jpg",slug:"veterinary-anatomy-and-physiology",publishedDate:"March 13th 2019",editedByType:"Edited by",bookSignature:"Catrin Sian Rutland and Valentina Kubale",hash:"75cdacb570e0e6d15a5f6e69640d87c9",volumeInSeries:2,fullTitle:"Veterinary Anatomy and Physiology",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7233",title:"New Insights into Theriogenology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7233.jpg",slug:"new-insights-into-theriogenology",publishedDate:"December 5th 2018",editedByType:"Edited by",bookSignature:"Rita Payan-Carreira",hash:"74f4147e3fb214dd050e5edd3aaf53bc",volumeInSeries:1,fullTitle:"New Insights into Theriogenology",editors:[{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Animal Nutrition",value:20,count:2},{group:"subseries",caption:"Animal Reproductive Biology and Technology",value:28,count:3},{group:"subseries",caption:"Animal Science",value:19,count:5}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:3},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:1},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:148,paginationItems:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/165328/images/system/165328.jpg",biography:"Vahid Asadpour, MS, Ph.D., is currently with the Department of Research and Evaluation, Kaiser Permanente Southern California. He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:null},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"357085",title:"Mr.",name:"P. Mohan",middleName:null,surname:"Anand",slug:"p.-mohan-anand",fullName:"P. Mohan Anand",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356696",title:"Ph.D. Student",name:"P.V.",middleName:null,surname:"Sai Charan",slug:"p.v.-sai-charan",fullName:"P.V. Sai Charan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"357086",title:"Prof.",name:"Sandeep K.",middleName:null,surname:"Shukla",slug:"sandeep-k.-shukla",fullName:"Sandeep K. Shukla",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356823",title:"MSc.",name:"Seonghee",middleName:null,surname:"Min",slug:"seonghee-min",fullName:"Seonghee Min",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Daegu University",country:{name:"Korea, South"}}},{id:"353307",title:"Prof.",name:"Yoosoo",middleName:null,surname:"Oh",slug:"yoosoo-oh",fullName:"Yoosoo Oh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:"Yoosoo Oh received his Bachelor's degree in the Department of Electronics and Engineering from Kyungpook National University in 2002. He obtained his Master’s degree in the Department of Information and Communications from Gwangju Institute of Science and Technology (GIST) in 2003. In 2010, he received his Ph.D. degree in the School of Information and Mechatronics from GIST. In the meantime, he was an executed team leader at Culture Technology Institute, GIST, 2010-2012. In 2011, he worked at Lancaster University, the UK as a visiting scholar. In September 2012, he joined Daegu University, where he is currently an associate professor in the School of ICT Conver, Daegu University. Also, he served as the Board of Directors of KSIIS since 2019, and HCI Korea since 2016. From 2017~2019, he worked as a center director of the Mixed Reality Convergence Research Center at Daegu University. From 2015-2017, He worked as a director in the Enterprise Supporting Office of LINC Project Group, Daegu University. His research interests include Activity Fusion & Reasoning, Machine Learning, Context-aware Middleware, Human-Computer Interaction, etc.",institutionString:null,institution:{name:"Daegu Gyeongbuk Institute of Science and Technology",country:{name:"Korea, South"}}},{id:"262719",title:"Dr.",name:"Esma",middleName:null,surname:"Ergüner Özkoç",slug:"esma-erguner-ozkoc",fullName:"Esma Ergüner Özkoç",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Başkent University",country:{name:"Turkey"}}},{id:"346530",title:"Dr.",name:"Ibrahim",middleName:null,surname:"Kaya",slug:"ibrahim-kaya",fullName:"Ibrahim Kaya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"419199",title:"Dr.",name:"Qun",middleName:null,surname:"Yang",slug:"qun-yang",fullName:"Qun Yang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Auckland",country:{name:"New Zealand"}}},{id:"351158",title:"Prof.",name:"David W.",middleName:null,surname:"Anderson",slug:"david-w.-anderson",fullName:"David W. Anderson",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Calgary",country:{name:"Canada"}}}]}},subseries:{item:{id:"14",type:"subseries",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11410,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,series:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983"},editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",slug:"ana-isabel-flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",slug:"christian-palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},onlineFirstChapters:{paginationCount:17,paginationItems:[{id:"81647",title:"Diabetes and Epigenetics",doi:"10.5772/intechopen.104653",signatures:"Rasha A. Alhazzaa, Thomas Heinbockel and Antonei B. Csoka",slug:"diabetes-and-epigenetics",totalDownloads:12,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"81099",title:"SK Channels and Heart Disease",doi:"10.5772/intechopen.104115",signatures:"Katherine Zhong, Shawn Kant, Frank Sellke and Jun Feng",slug:"sk-channels-and-heart-disease",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"80967",title:"Hot on the Trail of Skin Inflammation: Focus on TRPV1/TRPV3 Channels in Psoriasis",doi:"10.5772/intechopen.103792",signatures:"Lisa S. Martin, Emma Fraillon, Fabien P. Chevalier and Bérengère Fromy",slug:"hot-on-the-trail-of-skin-inflammation-focus-on-trpv1-trpv3-channels-in-psoriasis",totalDownloads:25,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"80952",title:"TRPV Family Ion Channels in the Mammary Epithelium: Role in Normal Tissue Homeostasis and along Breast Cancer Progression",doi:"10.5772/intechopen.103665",signatures:"Sari Susanna Tojkander",slug:"trpv-family-ion-channels-in-the-mammary-epithelium-role-in-normal-tissue-homeostasis-and-along-breas",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"80484",title:"The Use of Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC) to Study Ivermectin-Mediated Molecular Pathway Changes in Human Ovarian Cancer Cells",doi:"10.5772/intechopen.102092",signatures:"Na Li and Xianquan Zhan",slug:"the-use-of-stable-isotope-labeling-with-amino-acids-in-cell-culture-silac-to-study-ivermectin-mediat",totalDownloads:83,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Cell Culture - Advanced Technology and Applications in Medical and Life Sciences",coverURL:"https://cdn.intechopen.com/books/images_new/10797.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"80157",title:"Structural Determinants for Ligand Accommodation in Voltage Sensors",doi:"10.5772/intechopen.102094",signatures:"Abigail García-Morales, Aylin López-Palestino and Daniel Balleza",slug:"structural-determinants-for-ligand-accommodation-in-voltage-sensors",totalDownloads:88,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"79690",title:"Mitochondrial Channels and their Role in Cardioprotection",doi:"10.5772/intechopen.101127",signatures:"Keerti Mishra and Min Luo",slug:"mitochondrial-channels-and-their-role-in-cardioprotection",totalDownloads:85,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"79031",title:"Isolation and Expansion of Mesenchymal Stem/Stromal Cells, Functional Assays and Long-Term Culture Associated Alterations of Cellular Properties",doi:"10.5772/intechopen.100286",signatures:"Chenghai Li",slug:"isolation-and-expansion-of-mesenchymal-stem-stromal-cells-functional-assays-and-long-term-culture-as",totalDownloads:80,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Cell Culture - Advanced Technology and Applications in Medical and Life Sciences",coverURL:"https://cdn.intechopen.com/books/images_new/10797.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"78960",title:"Two-Dimensional and Three-Dimensional Cell Culture and Their Applications",doi:"10.5772/intechopen.100382",signatures:"Sangeeta Ballav, Ankita Jaywant Deshmukh, Shafina Siddiqui, Jyotirmoi Aich and Soumya Basu",slug:"two-dimensional-and-three-dimensional-cell-culture-and-their-applications",totalDownloads:251,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Cell Culture - Advanced Technology and Applications in Medical and Life Sciences",coverURL:"https://cdn.intechopen.com/books/images_new/10797.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"78812",title:"Nanotechnology Application and Intellectual Property Right Prospects of Mammalian Cell Culture",doi:"10.5772/intechopen.99146",signatures:"Harikrishnareddy Rachamalla, Anubhab Mukherjee and Manash K. Paul",slug:"nanotechnology-application-and-intellectual-property-right-prospects-of-mammalian-cell-culture",totalDownloads:122,totalCrossrefCites:1,totalDimensionsCites:1,authors:null,book:{title:"Cell Culture - Advanced Technology and Applications in Medical and Life Sciences",coverURL:"https://cdn.intechopen.com/books/images_new/10797.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"78274",title:"A Brief Concept of Cell Culture: Challenges, Prospects and Applications",doi:"10.5772/intechopen.99387",signatures:"Md. Salauddin",slug:"a-brief-concept-of-cell-culture-challenges-prospects-and-applications",totalDownloads:176,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Cell Culture - Advanced Technology and Applications in Medical and Life Sciences",coverURL:"https://cdn.intechopen.com/books/images_new/10797.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"78415",title:"Epigenetic",doi:"10.5772/intechopen.99964",signatures:"Mehmet Ünal",slug:"epigenetic",totalDownloads:137,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"77443",title:"Cyanobacterial Phytochromes in Optogenetics",doi:"10.5772/intechopen.97522",signatures:"Sivasankari Sivaprakasam, Vinoth Mani, Nagalakshmi Balasubramaniyan and David Ravindran Abraham",slug:"cyanobacterial-phytochromes-in-optogenetics",totalDownloads:186,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"75979",title:"Spatiotemporal Regulation of Cell–Cell Adhesions",doi:"10.5772/intechopen.97009",signatures:"Brent M. Bijonowski",slug:"spatiotemporal-regulation-of-cell-cell-adhesions",totalDownloads:171,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"76646",title:"Functional Mechanism of Proton Pump-Type Rhodopsins Found in Various Microorganisms as a Potential Effective Tool in Optogenetics",doi:"10.5772/intechopen.97589",signatures:"Jun Tamogami and Takashi Kikukawa",slug:"functional-mechanism-of-proton-pump-type-rhodopsins-found-in-various-microorganisms-as-a-potential-e",totalDownloads:199,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"76510",title:"Evolution of Epigenome as the Blueprint for Carcinogenesis",doi:"10.5772/intechopen.97379",signatures:"Zeenat Farooq, Ambreen Shah, Mohammad Tauseef, Riyaz A. Rather and Mumtaz Anwar",slug:"evolution-of-epigenome-as-the-blueprint-for-carcinogenesis",totalDownloads:190,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}}]},publishedBooks:{paginationCount:3,paginationItems:[{type:"book",id:"8545",title:"Animal Reproduction in Veterinary Medicine",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8545.jpg",slug:"animal-reproduction-in-veterinary-medicine",publishedDate:"January 20th 2021",editedByType:"Edited by",bookSignature:"Faruk Aral, Rita Payan-Carreira and Miguel Quaresma",hash:"13aaddf5fdbbc78387e77a7da2388bf6",volumeInSeries:6,fullTitle:"Animal Reproduction in Veterinary Medicine",editors:[{id:"25600",title:"Prof.",name:"Faruk",middleName:null,surname:"Aral",slug:"faruk-aral",fullName:"Faruk Aral",profilePictureURL:"https://mts.intechopen.com/storage/users/25600/images/system/25600.jpg",institutionString:"Independent Researcher",institution:{name:"Harran University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8460",title:"Reproductive Biology and Technology in Animals",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8460.jpg",slug:"reproductive-biology-and-technology-in-animals",publishedDate:"April 15th 2020",editedByType:"Edited by",bookSignature:"Juan Carlos Gardón Poggi and Katy Satué Ambrojo",hash:"32ef5fe73998dd723d308225d756fa1e",volumeInSeries:4,fullTitle:"Reproductive Biology and Technology in Animals",editors:[{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón",slug:"juan-carlos-gardon",fullName:"Juan Carlos Gardón",profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",institutionString:"Catholic University of Valencia San Vicente Mártir, Spain",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7233",title:"New Insights into Theriogenology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7233.jpg",slug:"new-insights-into-theriogenology",publishedDate:"December 5th 2018",editedByType:"Edited by",bookSignature:"Rita Payan-Carreira",hash:"74f4147e3fb214dd050e5edd3aaf53bc",volumeInSeries:1,fullTitle:"New Insights into Theriogenology",editors:[{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}}]},submityourwork:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/54985",hash:"",query:{},params:{id:"54985"},fullPath:"/chapters/54985",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()