The results of experiments on the effects of high temperature on old house borer larvae (hot air).
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"9052",leadTitle:null,fullTitle:"Psychoanalysis - A New Overview",title:"Psychoanalysis",subtitle:"A New Overview",reviewType:"peer-reviewed",abstract:"This book provides a comprehensive overview of the contemporary evolution of psychoanalytic thought and significant development in psychoanalytic methods, relating this information with other scientific disciplines and approaches. It also discusses the modern approach to psychoanalysis, psychoanalytic contributions to modern experience and culture, new empirical research derived from the practice of psychoanalysis, and more.",isbn:"978-1-83962-781-1",printIsbn:"978-1-83962-776-7",pdfIsbn:"978-1-83962-782-8",doi:"10.5772/intechopen.83047",price:119,priceEur:129,priceUsd:155,slug:"psychoanalysis-a-new-overview",numberOfPages:138,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"69cc7a085f5417038f532cf11edee22f",bookSignature:"Floriana Irtelli, Barbara Marchesi and Federico Durbano",publishedDate:"November 3rd 2021",coverURL:"https://cdn.intechopen.com/books/images_new/9052.jpg",numberOfDownloads:1963,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:0,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 17th 2020",dateEndSecondStepPublish:"July 8th 2020",dateEndThirdStepPublish:"September 6th 2020",dateEndFourthStepPublish:"November 25th 2020",dateEndFifthStepPublish:"January 24th 2021",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"174641",title:"Dr.",name:"Floriana",middleName:null,surname:"Irtelli",slug:"floriana-irtelli",fullName:"Floriana Irtelli",profilePictureURL:"https://mts.intechopen.com/storage/users/174641/images/system/174641.jpeg",biography:"Floriana Irtelli is a psychoanalyst/psychotherapist and member of the International Association for Relational Psychoanalysis and Psychotherapy (IARPP) who has been lecturing for several years at the Catholic University of the Sacred Heart, Milan, Italy. She has worked at Fatebenefratelli Hospital in Milan performing research and clinical activities. She is among the authors of several books, including A Fresh Look at Anxiety Disorders and Psychopathy - New Updates on an Old Phenomenon, and has published articles for the Journal of Affective Disorders, Research in Psychotherapy, and the Journal for Psychiatric and Mental Health Nursing. She has participated in numerous conferences, seminars, and congresses. 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He is currently the director of the Mental Health and Substance Abuse Department at ASST Melegnano e della Martesana. Dr. Durbano has had teaching assignments at the University of Milan (Nursing School) and the University of Castellanza (Master in Criminology). He has attended more than seventy local and national congresses and courses as an invited speaker and has published more than 180 papers. 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After working for almost ten years as a psychological consultant at Fatebenefratelli Hospital of Milan, where she completed a master’s degree in Psychodiagnostics, she worked for five years at Papa Giovanni XXIII Hospital in Bergamo, where she completed the formation for Neuropsychology. 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This chapter will begin by situating Janet’s contributions to the splitting of consciousness, and then discuss dissociation, and the resultant splintering of the self, as a ubiquitous response to early relational trauma. Specific dissociated self-states as they appear in anorexia and binge-eating disorder will be put forward, using detailed clinical vignettes to describe the paradoxical functions of these self-states, and the way they structure the eating-disordered patient’s relationship to food, eating, and their body. Treatment implications as they pertain to relational psychoanalytic technique will be considered.",signatures:"Shelley Heusser",downloadPdfUrl:"/chapter/pdf-download/73515",previewPdfUrl:"/chapter/pdf-preview/73515",authors:[{id:"326251",title:"M.A.",name:"Shelley",surname:"Heusser",slug:"shelley-heusser",fullName:"Shelley Heusser"}],corrections:null},{id:"76827",title:"The Real Self and the Ideal Self",doi:"10.5772/intechopen.98194",slug:"the-real-self-and-the-ideal-self",totalDownloads:376,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Every human psychic aspect, even the development of the Self, cannot be considered separately from the financial and cultural context in which it is inserted: ad a Matteo of fact the realization of individual freedom is correlated to broader economic and social changes, which influence the individual on self-realization. In the chapter, various theories about this topic and about the ideal self are explored, and it concludes by considering that self expression helps people to satisfy their real emotions and their real self, it also highlights the fact that self-realization and self-expression are among the highest needs on the human needs scale, and they affect human health.",signatures:"Floriana Irtelli, Federico Durbano and Barbara Marchesi",downloadPdfUrl:"/chapter/pdf-download/76827",previewPdfUrl:"/chapter/pdf-preview/76827",authors:[{id:"174641",title:"Dr.",name:"Floriana",surname:"Irtelli",slug:"floriana-irtelli",fullName:"Floriana Irtelli"},{id:"157077",title:"Dr.",name:"Federico",surname:"Durbano",slug:"federico-durbano",fullName:"Federico Durbano"},{id:"191704",title:"Dr.",name:"Barbara",surname:"Marchesi",slug:"barbara-marchesi",fullName:"Barbara Marchesi"}],corrections:null},{id:"74880",title:"Freud and Binswanger: An Asymptotic Relationship",doi:"10.5772/intechopen.94882",slug:"freud-and-binswanger-an-asymptotic-relationship",totalDownloads:156,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The relationship between Freud and Binswanger can be thought as a productive misunderstanding. In search of institutional recognition, Freud sees in Binswanger above all a representative of classical psychiatry, moreover director of a prestigious institution, while the latter aspires to shatter this same psychiatry which seems to him marked by the discrediting of the patient. This misunderstanding will take the form of a doctrinal rather than a practical disagreement, centered on the notion of drive - too biological according to Binswanger - and in particular on the latter’s refusal of the drive origin of the ego and of the censorship. For Binswanger, psychiatry can renew itself from the inside by opening up to a philosophical, phenomenological, approach to the patient and his world, a world in which it is first necessary to enter through a patient-doctor co-journey in order to reconstitute the conditions for living together. For Freud, the therapeutic imperative proscribes such recourse to an external authority, the world of the philosopher being itself, by its closure on itself, suspect. In the end each of the respective thoughts of the two men will progress in contact with the other without ever a perfect agreement being able to take place.",signatures:"Philippe Veysset",downloadPdfUrl:"/chapter/pdf-download/74880",previewPdfUrl:"/chapter/pdf-preview/74880",authors:[{id:"328497",title:"Dr.",name:"Philippe",surname:"Veysset",slug:"philippe-veysset",fullName:"Philippe Veysset"}],corrections:null},{id:"74069",title:"Is the Death Instinct Silent or Clinically Relevant? From Freud’s Concept of a Silent Death Instinct to Understanding Its Clinical Manifestations",doi:"10.5772/intechopen.94444",slug:"is-the-death-instinct-silent-or-clinically-relevant-from-freud-s-concept-of-a-silent-death-instinct-",totalDownloads:310,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"When Freud introduced his concept of the death instinct in Beyond the Pleasure Principle (1920) he solved three theoretical problems which could not be explained by the one drive theory: masochism, repetition compulsion and the negative therapeutic reaction. The concept of two inherently opposed instincts remained one of the most controversial parts of Freud’s theory. For Melanie Klein, Freud’s idea of the death instinct was a powerful instrument in solving her greatest problems of integrating her clinical evidence of an earlier, very harsh superego. In Freud’s account, the superego was the manifestation at birth of the death instinct operating in destructiveness towards the person, as he had argued. In this way, Klein put – as Hinshelwood claims – clinical “flesh on the bones of Freud’s theory of the death instinct.” I will describe the development of Freud’s theory and how this was elaborated by Klein and her followers Bion, Esther Bick, Segal and Rosenfeld. With three clinical vignettes--from an Infant Observation, a child analysis and an adult analysis--the clinical use of the concept will be illustrated.",signatures:"Gertraud Diem-Wille",downloadPdfUrl:"/chapter/pdf-download/74069",previewPdfUrl:"/chapter/pdf-preview/74069",authors:[{id:"326205",title:"Prof.",name:"Gertraud",surname:"Diem-Wille",slug:"gertraud-diem-wille",fullName:"Gertraud Diem-Wille"}],corrections:null},{id:"73509",title:"From the Shadow to the Light: Navigating Life as a Mother with a History of Substance Use and Parenting a Child Healing from Early Childhood Trauma",doi:"10.5772/intechopen.94073",slug:"from-the-shadow-to-the-light-navigating-life-as-a-mother-with-a-history-of-substance-use-and-parenti",totalDownloads:215,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"We report on an innovative in-patient residential recovery program that serves as a model for those who treat low-income women with substance use and psychiatric problems and their children. The case discussed details the psychotherapeutic treatment of a mother and child that was carried out within the protection of the program’s seeking safety, trauma informed model of care. The treatment demonstrates the sensitive care that is needed when working with a young child with a history of early childhood trauma and the favorable ways that holding the mother in mind freed her to be emotionally available to her son. In this situation, the therapist provided an emotionally-attuned interpersonal therapeutic relationship and created features of safety in the environment that helped the child develop an emerging reorganized protective structure to safely explore his fears. The mother and child can follow a course of recovery from traumatic experiences within the context of favorable conditions, thereby interrupting the intergenerational dynamics of early relational trauma.",signatures:"Linda M. Perez, Suzi E. Desmond and Cheryl J. 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To the contemporary subjective constitution, the human being is complex and determined by a myriad of biological, psychological, and social factors. Thus, culture is not external to the dimensions making up the subject, and technology plays a key role in people’s current lives. Within the psychoanalytical technique, the setting has changed and adapted to the different social contexts, to the needs of each subject and also of the analyst. Contemporary psychoanalysis faces the challenge of setting up new scenarios to fit a new present that is taking shape. These are mixed settings, where the physical and virtual presences complement each other, simultaneously and alternately. Both the virtual and the physical realities are different and, therefore, do not replace each other. Thus, the purpose of this chapter is to reflect on the conditions that make possible the analytical encounter mediated by technology.",signatures:"Valeria Corbella",downloadPdfUrl:"/chapter/pdf-download/74300",previewPdfUrl:"/chapter/pdf-preview/74300",authors:[{id:"326207",title:"Ph.D.",name:"Valeria",surname:"Corbella",slug:"valeria-corbella",fullName:"Valeria Corbella"}],corrections:null},{id:"73826",title:"Culture Free CBT for Diverse Groups",doi:"10.5772/intechopen.93904",slug:"culture-free-cbt-for-diverse-groups",totalDownloads:339,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Traumatic experiences are known to have a significant impact upon one’s physical and mental health. Post-traumatic stress disorder (PTSD) is understood to be a common mental health consequence of trauma. However, Complex Trauma and consequences of adverse childhood experiences appear more prevalent and a serious public health concern that hinders the individual’s daily existence, thus emphasising the need to implement a culturally free treatment intervention. In this chapter, we begin by introducing traumatic experiences in several contexts and explore the treatment for trauma. It will focus on a research study that employs Comprehend, Cope and Connect (CCC), a third wave CBT approach, to deliver a culturally free form of therapy that has been adapted for individuals from diverse populations. The CCC approach’s relevance to cultural adaptation is explained and discussed through the use of two case examples from the main study. The Culture Free study found that CCC was both feasible and acceptable in diverse populations, echoing existing research on cultural adaptations which found use of mindfulness to be accepted and appreciated as an effective intervention that can elicit concrete positive change across a broad range of mental health presentations, including trauma and trans-diagnostically. 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The insecticidal factors used in those methods include, for example, high temperature. Insects, as all living organisms, can exist only in appropriate thermic conditions. They are poikilothermic animals; however, they have a limited ability of thermic regulation by changing the intensity of breathing and evaporating. In general, however, the temperature of their bodies is preconditioned by ambient temperature.
\nResearch on wood-boring insect control in wooden constructions was first started in Denmark [1–3]. Also in Denmark, in the 1930s, the method of exterminating the old house borer by heating wooden constructions using hot air was developed. The method was soon introduced in Germany as well. To produce masses of hot air, DEUBA heaters were applied. Hot air at the temperature of 100–120°C was inflated into attics of wooden buildings. Next, the temperature in the attics was maintained at the level of 80–100°C for several hours. Such thermic regime caused heating of the internal layers of constructional wood up to the temperature of at least 50°C. Several companies performing the old house borer extermination advertised their services in industry periodicals in the 1930s, for example, by the name of DEUBA (Hanover) and DEOB (Leipzig). After the Second World War, the method was continuingly applied on a wide scale. Specialist literature of that period is full of descriptions of the old house borer control in wooden roof constructions and the positive effects of the method [3–10].
\nFundamental knowledge on thermic conditions of the old house borer extermination was acquired thanks to the research of Wichmand [1], Jensen [2], Schmidt and Schneider [11] and Becker and Loebe [12]. The results obtained in those examinations, however, were very diverse. The research was continued by Krajewski [13]. As for heating wood with solid-state objects and with infrared radiation, both methods have proven to be unpromising [13].
\nThe phenomenon of a very limited resettlement in the wood by the old house borer after applying the heating method of insect control was also widely discussed in German periodicals at the end of the 1950s and in the early 1960s. This matter, however, of great interest and examined by the author, is outside the scope of the present chapter.
\nThe effect of heating whole volume of wood can be also obtained using electromagnetic field of high frequencies, that is, high-frequency and ultra-high-frequency radiation, and especially microwaves. In the research, homogeneous or scattered field was applied. The term “microwaves” is usually attributed to the spectrum of electromagnetic radiation of frequencies ranging from 0.3 to 300 GHz, that is, of wavelengths ranging from 1000 to 1 mm, respectively. As far as high-frequency radio waves can be emitted in the form of both homogeneous and scattered field, in the case of microwaves, due to technical possibilities, only scattered field is available for practical purposes. According to Thomas and White [14], the first experiments on exterminating the
Currently, a renewed interest in microwaves as a wood-boring insect control factor can be observed. Microwave heating has been recently approved by the Food and Agriculture Organization (FAO) as a significantly effective phytosanitary treatment for wood packaging materials. According to International Standards for Phytosanitary Measures (ISPM) 15 [30], target organisms are eradicated if a temperature higher than 60°C is maintained for 60 s across the entire profile of the board. The study, using pallet boards, was carried out in order to set up a treatment program that would meet ISPM 15 [30] requirements in terms of wood temperature and mortality of the insects. A 4-m long industrial tunnel oven (maximum power of 28.8 kW) was used to perform the experiments. The temperature was measured using a VarioCAM infrared camera [28, 29, 31]. The results obtained in the experiments were satisfactory. Some research in the recent years focussed only on the temperature of the wood treated with microwaves [32–34] and on the physical effects involved in such microwave processing.
\nIn spite of a relatively large number of publications and a long-time practice in using hot air and microwaves for the aims of wood-boring insect control, the discrepancies in results obtained by researchers working independently in the field of susceptibility of well-grown old house borer larvae to heating the wood with hot air have not been explained so far. Several conditionings connected with applying microwaves to wood-boring insect control also require further explanation. It is the author’s intention to provide grounds for such explanations in the present chapter, being a summary of the author’s 15-year-long research on those two issues. The author’s research has covered several species of wood-boring insects. However, it mainly focussed on the old house borer larvae (
The experiments on lethal effect of high temperature were constructed based on the results obtained by Becker and Loebe [12]. Variants of temperature and duration of action were chosen. For all experiments, well-grown individuals of the old house borer larvae (
Effective time of exposure to high temperature in the old house borer larvae control procedures and methods of exposing larvae to hot air in different experiments (according to Krajewski [
The only significant difference in relation to the experience of Becker and Loebe [12] was the way to put the larvae in the dryer. Becker and Loebe [12] installed the larvae in dryer an wooden plate (see Figure 1). Temperature of wood at the start was as temperature of air in the laboratory (probably about 20°C). The type of incubators in the experience of Becker and Loebe [12] was not given in the publication.
\nTen old house borer larvae were used in each variant of the experiment (i.e. for each given temperature and duration), exactly as in the experiment of Becker and Loebe [12]. The masses of the old house borer larvae used in the test ranged from 20 to 230 mg (usually 70–150 mg). Each testing group of insects was compared to a control group of 10 larvae which were not exposed to high temperature. Both the testing larvae and the control group larvae were then put into wooden blocks with a glass allowing observation of behaviour of the larvae and their boring into the wood (Figure 2).
\nSamples of wood used by the author in experiments on using microwaves for the old house borer larvae control (according to Krajewski [
Apparatus radiating microwaves of the frequency of 2.45 GHz (wavelength of 12.2 cm) in the form of scattered field was used in the experiments. Two prototypical mobile devices of 0.6 and 2.4 kW and a microwave chamber of 1 kW were produced at Wroclaw University of Science and Technology for PP PKZ Wroclaw Branch.
\nIn the experiments, blocks sized 60 × 120 × 200 mm3 were used (see Figure 2), made from:
\nScots pine wood (
spruce wood of density ranging from 0.41 to 0.45 g/m3 (with the average value of 0.43 g/m3)
\nand fir wood of density ranging from 0.41 to 0.45 g/m3 (with the average value of 0.43 g/m3).
\nThe radius of the heartwood semi-cylinder ranged from 30 to 40 mm. Different series of blocks were used for testing biocidal qualities of microwaves in each variant of the experiment, and for estimating the temperature corresponding to each variant.
\nThe old house borer larvae were used in the experiments. The larvae were put into groups of 10 in each block, inside the holes drilled as shown in Figure 2. The length of each drilled path ranged from about 1.5 to 2 times the length of larvae body length. The diameter of each hole was a little bigger than the width of larvae. After introducing the larvae, the holes were plugged with a cotton wool cork. The blocks with larvae inside were first kept in an incubator in the temperature of 28°C, with air humidity of about 90%. After the larvae had bit into the wood, they were kept in the temperature of 20°C and air humidity of 70–75% for 12 weeks. For each variant of the experiment (i.e. power of device/time of exposure/0 mm distance between antenna and the surface of wood), three blocks were used (1 pine wood, 1 spruce wood and 1 fir wood). As a rule, microwaves were radiated by the apparatus of 0.6 kW individually onto each block, in two parallel straps of 60-mm width, onto the biggest surface opposite heartwood, with 0 mm distance between the radiating antenna and the surface of the wood. Most of the obtained results of larvae mortality and temperature measurements were handled using linear regression analysis.
\nAdditionally, for each time of exposure, sapwood blocks sized 50 × 25 × 15 mm3 with larvae placed individually into the carved path behind the glass (Figure 2) were also exposed to microwave processing. For each time variant of the experiment, 10 blocks were used (i.e. 10 larvae).
\nOnly in a few variants of the experiment two other devices of different powers were used, as well as the 0.6 kW apparatus, with the distance between antenna and wood surface set to 100 and 200 mm. In the case of a 100- and 200-mm distance, microwaves were radiated in a single strap of 120-mm width. In those variants of experiment, single wood blocks were used.
\nFor measuring the temperature of the wood, a platinum resistance sensor of electric current and a digital electric meter V 543 were used. Electric resistance of the sensor was measured directly after radiation inside holes drilled in the front of each block and half the length of the block, in the distance of 10, 30 and 50 mm from the surface exposed to microwave radiation. The resistance of the sensor was then converted into wood temperature. Temperature measurements were performed for the variants of the experiment with 0 mm distance between the radiating antenna and the surface of the wood (for all devices of different powers) as well as for the wood exposed to radiation from the 0.6 kW device with 100-mm distance between the antenna and the surface of the wood.
\nAdditionally, three systems imitating chocks of constructional wood of 300 mm thickness were tested. For this purpose, three models were made from blocks of pine wood sized 60 × 120 × 200 mm3, tightly attached by the 120 × 200 mm2 surfaces. The 0.6 kW apparatus was used. Each model was radiated with microwaves in two straps of 60 mm width, with 0 mm distance between the antenna and the surface of the wood. Time of exposure for each model was 5, 10 and 15 min.
\nThe results of the experiment on the impact of high temperature, obtained with the use of hot air, on the old house borer larvae are shown in Table 1 and Figure 1. In Figure 1 only those variants of the experiment are shown where all the larvae were killed. Results obtained in earlier experiments by other researchers are also shown in Figure 1.
\nExposure time (min) | \nThe average time of onset of mobility larvae after exposure (days) – in parentheses are extreme cases | \nThe average time after exposure, when the larvae have taken a wood boring (days) – in parentheses are extreme cases | \nThe average completion time entry larvae in the wood (days) – in parentheses are extreme cases | \nThe level of mortality of larvae (%) | \n
---|---|---|---|---|
Temperature 50°C | \n||||
180 | \n2.0 | \n5.0 (3–6) | \n8.3 (6–12) | \n0 | \n
240 | \n2.6 (2–4) | \n10.3 (7–14) | \n13.2 (9–17) | \n0 | \n
300 | \n2.8 (2–6) | \n7.6 (4–12) | \n13.2 (10–20) | \n0 | \n
360 | \n4.8 (4–6) | \n14.0 (12–16) | \n22.0 (20–24) | \n20 | \n
Temperature 55°C | \n||||
20 | \n2.6 (2–4) | \n4.6 (4–6) | \n6.2 (6–7) | \n0 | \n
30 | \n3.5 (3–4) | \n5.5 (5–6) | \n9.0 (8–10) | \n60 | \n
40 | \n8.7 (4–16) | \n13.0 (6–20) | \n17.3 (15–23) | \n20 | \n
50 | \n3.0 (2–4) | \n6.0 (4–8) | \n12.0 (10–14) | \n80 | \n
60 | \n0 | \n0 | \n0 | \n100 | \n
Temperature 60°C | \n||||
5 | \n4.0 (3–5) | \n6.0 (7–8) | \n9.0 (8–10) | \n60 | \n
10 | \n5.5 (4–7) | \n15.0 (14–16) | \n20.0 (19–21) | \n60 | \n
15 | \n0 | \n0 | \n0 | \n100 | \n
Temperature 65°C | \n||||
5 | \n0 | \n0 | \n0 | \n100 | \n
10 | \n0 | \n0 | \n0 | \n100 | \n
The results of experiments on the effects of high temperature on old house borer larvae (hot air).
The process of heating in the case of wood of 60-mm thickness with microwaves (0–5 min) using the 0.6 kW device with 0 mm distance between the radiating antenna and the surface of the wood and the process of cooling of wood (5–35 min) measured 10 mm (● —), 30 mm (▲ - - - -), and 50 mm (■ − ∙ − ∙ − ∙) below the surface (according to Krajewski [
The relationship between mortality of the old house borer larvae and the time of exposure to microwaves radiated by the 0.6 kW device with 0 mm distance between the radiating antenna and the surface of the wood in the cases of pine wood (●), fir wood (■), and spruce wood (▲) of 60 mm thickness (according to Krajewski [
Average temperatures of wood measured 10, 30 and 50 mm below the surface after heating the wood with microwaves radiated by the 0.6 kW device are shown in Figure 3. The process of cooling of the wood is also illustrated. The distance between the microwave radiating antenna and the surface of the wood was 0 mm in this case. In Figure 4, mortality rate of the old house borer larvae in pine wood, fir wood and spruce wood, determined in the experiment, is shown. In this case, the thickness of the wood was 60 mm and it was heated using microwaves produced by the 0.6 kW device with 0 mm distance between the radiating antenna and the surface of the wood.
\nAverage temperatures of pine wood of 60 mm thickness, heated with the radiating antenna located 100 mm from the surface of the wood, are shown in Figure 5. Mortality rate of the old house borer larvae obtained in the experiment with 100 and 200 mm distance between the radiating antenna and the surface of the wood is shown in Figure 6.
\nAverage temperature of pine wood heated with microwaves radiated by the 0.6 kW device with 0 mm (● —) and 100 mm (▲ - - - -) distance between the radiating antenna and the surface of the wood (according to Krajewski [
Mortality of the old house borer larvae after exposure to microwaves radiated by the 0.6 kW device with (● —), 100 mm (▲ - - - -), and 200 mm (■ − ∙ − ∙ − ∙) distance between the radiating antenna and the surface of the wood (according to Krajewski [
The results of heating wood of larger section (thickness of 300 mm, i.e. 5 blocks 60-mm thick, tightly attached) are shown in Figure 7. The graphically suggested process of thermal degradation of the wood is related to phenomena between pyrolysis and ignition 5 to 30 mm below the surface of the wood.
\nThe temperature of different layers of wood of 300 mm thickness heated with microwaves radiated by the 0.6 kW device with 0 mm distance between the radiating antenna and the surface of the wood after 5 min (● —), 10 min (▲ - - - -), and 15 min (■ − ∙ − ∙ − ∙) of exposure (according to Krajewski [
The effect of faster heating of the wood radiated with microwaves produced by devices of higher output power is shown in Figure 8. In the case of 0.6 and 2.4 kW devices, the distance between the radiating antenna and the surface of the wood was 0 mm. The 1.0 kW device was a microwave chamber, refocalising the scattered microwave field.
\nMortality of the old house borer larvae after exposure to microwaves radiated by the 0.6 kW (● —), 1.0 kW (▲ - - - -), and 2.4 kW (■ − ∙ − ∙ − ∙) devices (according to Krajewski [
Unwanted effects of heating of pine wood radiated with microwaves in laboratory test conditions and in practice are shown in Figures 9 and 10, respectively. In Figure 9, pine wood blocks are shown which are used to examine the effectiveness of the old house borer larvae control.
\nMonitoring the temperature of the wood by thermal imaging can cause distortions to the view of the situation: the areas of high temperature, visible on the screen, can cover layers of much lower temperature, harmless to the larvae (photo by CARSEKT).
Resin melting in pine wood after exposure to microwaves radiated in practice by the 0.6 kW SAURUS device made in Italy (photo by CARSEKT).
All larvae surviving from high temperature exposure fell into thermic numbness because the duration of the procedure had not been long enough to cause mortal effects. The numbness lasted for a period of time depending on variant of the experiment (see Table 1). Larvae from the control group remained active for all the time, continuously carving the wood. In the experiments of Becker and Loebe [12], the phenomenon of thermic numbness of larvae was also observed if the duration of exposure to high temperature had been too short to cause death of the exposed individuals. Larvae surviving from microwave exposure also fell into numbness.
\nDifferences in results of the relationship between larvae mortality and the temperature and duration of exposure, obtained by different researchers, result from methodological differences of their experiments. As stated in Becker and Loebe’s publication [12], they placed the larvae onto a wooden plate in room temperature (about 20°C) and only after that the substrates with larvae were put inside the heating chamber. For this reason, they did not obtain the assumed homogeneous ambient temperature. Larvae were thus exposed to hot air operating from the top, while the wood in the bottom was heated only after a long period of exposure. For this reason, the results obtained by Becker and Loebe [12] are close to the author’s results in the temperatures ranging from 50 to 55°C and to the results of Schmidt and Schneider [11]. Different course of the curve of relationship between mortal exposures and temperatures in the range from 54/55 and 60°C, obtained by Becker and Loebe results [12] from using wood which did not reach the temperature of the heating chamber. It seems improbable even at first glance that mortal impact of the temperature of 60°C on the old house borer larvae occurs only after as long as 50 min, unless a factor comes into play which significantly changes the assumed conditions of the experiment. In Becker and Loebe’s experiment [12], only about 1/3–1/2 of the larvae body surfaces was exposed to the assumed temperature for the whole time of a given variant of the experiment. The size of the protected surface of the body depends on whether the wood was smooth or carved, a matter which is not covered by Becker and Loebe’s publication [12].
\nA completely different location of the curve, related to the experiments of Wichmand [1] and Jensen [2], results from putting the larvae on a cardboard (again, no notice whether it was plain or corrugated) before placing them into the heating chamber. It can be assumed that the thin layer of cardboard heated much faster than wood in Becker and Loebe’s experiment [12]. However, the influence of a much poorer resistance of Danish larvae (the area of Atlantic climate) as compared to the resistance of larvae from the surroundings of Berlin (much bigger impact of continental climate), suspected by Becker and Loebe [12], cannot be definitely ruled out. Larvae in Schmidt and Schneider’s experiment [11] were placed inside holes drilled in previously heated wood. However, a small number of individuals (2–3) in each variant of their experiment make their results unreliable.
\nAs for the results of the author’s research [13] on resistance of various species of
The temperature in a given place in a piece of wood can be calculated using an appropriate formula. Instead of performing time-consuming calculations, the parameters of the procedure of the old house borer control can be established in practice with the help of a suitable diagram. In order to estimate quickly the time of heating the inside of the cross section of a wooden constructional element up to the temperature of 55°C, deadly for the old house borer larvae, Schmidt et Schneider [11] presented applicable charts. The time required to heat wood to the temperature of 55°C ranges from 1 h (cross section is 100 × 140 mm2; temperature at start time is 50°C; and temperature of inflated air is 90°C) to 14 h (cross section is 200 × 240 mm2; temperature at start time is 0°C; and temperature of inflated air is 60°C). For example, a wooden constructional element of 180 × 180 mm2 cross section in temperature of around 20°C at start time must be heated for 8 h if the temperature of inflated air is kept at about 60°C. According to the theory, time value taken from Figure 1 must be added to the value of time taken from the chart. However, because of slowness of the process of heating the wood to the assumed temperature and slow returning of the heat by the wood, temperature above 40°C also acts destructively to larvae by gradual dehydration.
\nThe energy absorbed by a dielectric solid (
where
\nf – frequency of the wave,
ɛr – relative permittivity of the material,
ɛ0 – permittivity of free space,
E – electric intensity,
V – volume of the solid,
t – time of exposure
δ – dielectric loss angle.
Particles of water are dipoles. Placed in an electromagnetic field, for example, microwave field, they are oriented towards the rapid field changes, causing molecular friction. Apart from the qualities of the material, electric intensity and frequency of the wave are decisive. The formula given above illustrates some relationships well, yet has little practical usefulness, as modern devices, based on cavity magnetrons, produce heterogeneous (scattered) electromagnetic microwave field. Electric intensity of the field is thus varied in different points in the volume of a wooden block.
\nEven if the reports from research [14, 16–18] using high-frequency and ultra-high-frequency radio waves, not being microwaves, are left apart, it is still difficult to compare the results obtained by the author with the results from publications by Van den Bruel et al. [19], Bollaerts et al. [20], Berwig and Schühly [21], Watson and Moss [22], Bletchly [23], Henin et al. [28]. All those experiments, however, achieved an effective method of the old house borer larvae control, resulting from heating wood in microwave field. It is presently emphasised that for the effectiveness of the method, a temperature of 60°C must be maintained in whole interior of the wood for at least 60 s [28, 29, 31]. Wood heated with microwaves, being a good thermal insulator, allows to maintain the temperature at the level of 55–60°C for a relatively long time even after cessation of microwave radiation (see Figure 3). The temperature can also be maintained after cessation of electromagnetic field action. However, the temperature obtained in this way in different areas of the wood is varied. Most publications omit the effect of gas pressure, resulting from microwave radiation of the wood. It was closely noted only by Berwig and Schühly [21]. Pressure of gases, especially vapour, is so big that it causes detaching of bark from the surface of conifer wood. The effect can also act to a degree destructively to insects.
\nUnfortunately, scattered microwaves lose much of their effectiveness in the old house borer larvae control procedures (see Figures 5 and 6) which is related to the decrease of electric intensity with growing distance between the radiating antenna and the surface of the wood. The effect can be counteracted, for example, by using industrial tunnel oven, as did Henin et al. [28, 29]. A relatively big power of the applied industrial tunnel oven allows fast wood heating. The procedures of phytosanitary treatment of European pallets by microwave radiation provided for 22-mm wooden planks facilitate the task. It is also assumed that heating wood with microwave radiation concerns only wood of thickness up to 200 mm [31]. Negative effects of heterogeneous heating of wood blocks of big thickness using microwaves in the form of scattered field are shown in Figure 7. For this reason, application of microwave radiation to the old house borer larvae control in building constructions is a significantly more difficult task. Some unexpected thermic effects can also occur in frozen wood, as was shown by Henin et al. [31]. Also, it must be noted that monitoring the wood by thermal imaging (Figure 9) can cause distortions to the view of the situation. Areas illustrated with high temperatures can cover layers of wood of much lower temperatures than the temperature required to eliminate larvae. This issue concerns in particular building constructions, where there is not always the possibility to measure the temperature from two directions: from the side of microwave radiation and from the opposite side. The most heated areas of the wood are shown very bright but they can cover much colder layers. Such cases were observed in practice during the old house borer larvae extermination in wooden constructions.
\nSome unwanted effects of heating the wood for the aims of the old house borer larvae control include resin melting in the case of some wood species, for example, Scots pine wood. It was observed in research and was later confirmed in practical application of microwave heating in building constructions (Figure 10).
\nCondition of pine wood covered with gilding after exposure to microwaves radiated by the 0.6 kW device (photo by Krajewski): (A) 2 min and (B) 4 min.
The application of microwave heating for the aims of wood destroying insects control is limited by the presence of accompanying materials used in the construction. The author carried out ample observation, yet its results cannot be discussed in detail due to the limitations of the publication. Wood contraction, caused by desorption as a result of drying the whole volume of the wood, may result in very small cracks in both monochrome and polychrome made with some kinds of paint, for example, tempera. In the case of oil paint, binder may melt or blisters may occur on the surface of the wood. Particular threats are caused by the presence of thin electrical conductors, for example, gilding (Figure 11). According to Maxwell’s law, electric current flows in a conductor placed in electromagnetic field. Current flow is accompanied by electrical resistance, and resistance results in heating which can even lead to ignition of the wood. The presence of 2-inch nails in the wood, exposed to microwave radiation, which guarantees effectiveness of the old house borer larvae control with a 0.6 kW device, is not dangerous. However, an attempt to destroy
The possibility of effective wood-boring insect control using hot air and microwave radiation was proven many years ago. However, the author’s research and practical observation allow to formulate several proposals, giving a new view on some issues:
\nThe differences in estimations of the old house borer larvae susceptibility to high temperatures contained in different publications result mainly from methodological differences of the performed experiments. The author’s result point to purposefulness of taking up unexplained issues from pas publications, even very old ones.
Because of high thermic insulation of wood, practical application of wood-boring insect control both using hot air and microwaves shapes favourably in regard to theoretical indications basing on research. The biocidal effects of the suggested temperatures of 55°C (in older publications) and 60°C (in newer publications) do not occur suddenly. Temperatures just below the theoretical limits may be hot enough to cause the effect of dehydration of larvae. In the case of microwaves, heating process is indeed very quick, but it involves releasing vapour from the wood and thus growth of pressure. Using hot air in order to heat the wood requires more time, but in this case also, besides protein denaturation, dryer effect occurs. In both methods, temperatures causing not only wood drying but also larvae dehydration are maintained for a long time.
It seems that microwave radiation method has better possibilities of application using industrial tunnel oven for phytosanitary treatment of wood packaging material than for wood-boring insect control in the wood of building constructions. Covering a larger space with microwave field refocalised in industrial tunnel oven and smaller thickness of wood packaging material create the possibility to obtain a more homogeneous temperature distribution in the element subjected to insects control. On the other hand, devices used to wood-boring insect control in wood of building constructions operate on the basis of “microwave brush”, covering small areas of the wood. Even a small distance between the microwave radiating antenna and the surface of the wood causes huge decrease in effectiveness of the procedure.
Microwaves always cause some problems concerning accompanying materials in wooden constructions. Special attention must be paid to metals, including metal connectors (nails, screws etc.), also in the case of wood packaging materials. Rapid wood contraction resulting from wood drying definitely excludes applying microwaves to treatment of coated wood, even if the coating is relatively resistant to high temperatures.
Tsunami-like digital revolutions cause a sharp transformation of the world from modern society to Information society that eventually changed the scientific paradigms and approaches. Therefore, there appear several problems related to major clinical problems. Similarly, there emerge gaps between the cathartic effect of clinical interviews and therapeutic alliance. This gap also exists in the deeper understanding of the real experiences of the client and the help of the therapist. This chapter discusses the new diagnosis and treatment opportunities of post-traumatic stress disorder (PTSD) that appeared in stunning psychotherapy techniques and approaches and the changing role of psychiatrists. Since the shift in society and technological advancements doubles the burden of psychiatrists to a large extent, conventional diagnoses and therapies for PTSD do not work properly. It seems inevitable that recent developments and challenges surpass conventional approaches to PTSD that can easily miss embracing the overwhelming realities that those people experience.
This study, therefore, aims to explore and exemplify new diagnostic and therapeutic approaches to PTSD cases by embracing the digital revolutions of society with their novel implications and insights. To search for new working diagnoses and treatment opportunities, PTSD issues are analyzed by different angles and multi perspectives developed by certain disciplines. For Tarhan, the algorithm for the diagnosis and treatment process of PTSD has three main dynamics—ontological, sociological, and clinical (see Figure 1). These three dynamics are expanded by two more additional dynamics. Recent research on genomics and epigenomics in neuro-biological perspectives along with clinical and neuro-imaging perspectives are presented that they conglomerate new insights and implications for PTSD. They are explained in detail in the second and third parts of the chapter, respectively.
The algorithm for the diagnosis and treatment process of PTSD.
The underlying reason for designing this chapter in five subsequent parts comes from the need to shed some new light on PTSD from different angles. The latest technological innovations in genomics, epigenomics in neuro-biological perspectives, and clinical and neuro-imaging perspectives challenge the psychiatrists’ role as they are expected to update their reference frames related to PTSD for diagnosis and treatment alternatives. Therefore, the study presents five interdisciplinary domains that are correlated with each other thematically as they particularly aimed to answer the question of what possible new approaches we have in terms of PTSD.
To pursue the goals mentioned above, the first part of the chapter starts with an ontological discussion that analyzes PTSD in terms of epidemiology and existential questions. In addition to those dimensions, the heavy impact of Coronavirus Disease (COVID-19) on PTSD cases and its sociopolitical consequences are portrayed in detail. This first part also throws a question as to whether post-traumatic growth is possible or not. It underlines that ontological well-being should not be ignored as healthy mindsets that eventually produce a healthy society. Ontological well-being and positive psychology are given as the ultimate aims of the science that would work for the benefit of the whole society counting PTSD patients. However, it is a challenging standpoint to offer a therapy that can work for the whole society. In the PTSD context, if social psychiatry utilizes cutting-edge approaches by wisely utilizing the technological advances of the cyber era, the mental and social well-being of society can be reached.
The second part follows the ontological discussions with Neuro-Biological Perspectives on Genomics and Epigenomics in PTSD. This part also discusses current Genome-Wide Association Studies and current Epigenome-Wide Association Studies. PTSD can occur at the organic, cellular, and molecular level due to the effect of an external event such as psychological trauma, as well as inherited from generation to generation. In PTSD, genetic and epigenetic studies are prioritized based on biological research because they are promising in elucidating molecular functioning and finding biomarkers. The goal of these studies is to lay the groundwork for new and preventive treatments to ameliorate the symptoms and the disease. In this context, there is current evidence for the potential of current genetic and epigenetic studies from the biological risk factors of PTSD.
In a similar vein, the third part of the chapter portrays the clinical and neuro-imaging perspectives and clinical overviews of PTSD. This part argues the practical psychological treatments, such as neuromodulatory and neurobiological treatments. This part presents the Post-Traumatic Stress Disorder Checklist for DSM-5 as a self-report measure to evaluate the presence and severity of PTSD symptoms.
The fourth part expands the topic by adding the neuro-developmental perspective of PTSD, particularly in the context of children. Here, PTSD is analyzed by emphasizing the significance of Brain Development. This part is followed by a detailed explanation of adverse childhood experiences (ACE) and their relation to PTSD.
The fifth and final part of the chapter reviews PTSD in its correlation to the new paradigms and changes in Information Society. This part brings forward those transformations of society and media that necessitate searching for new discourses and alternative digital therapies for PTSD. Here, within the context of Attachment Theory, this final part warns of the potential evil that is inherent in new media, particularly in Digital Habitus and Dark Web. It would be wise to be cautious toward the widespread acts of cyber violence. It highlights the significance of a new emotional repertoire that can be identified as new types of traumas seen in digital habitus. In conclusion, since new trauma types emerged on cyber platforms, the mission and goal of social psychiatry are recommended to adopt these changes. Therefore, keeping pace with these transformations is widening the job definition of contemporary psychiatrists. Searching for new ways and counter activities to prevent society from demonic sides of social media ultimately shaped the agenda of psychiatrists.
Some basic information regarding the understanding of PTSD can be summarized as follows—PTSD is one of the few disorders among the Diagnostic and Statistical Manual of Mental Disorders (DSM) diagnostic categories regarding the etiology. Therefore, it is relatively easy and unproblematic to diagnose a PTSD case. The trauma mentioned there may appear in different situations and features. They can be concrete, obvious, extreme, unusual, unexpected, unforeseen, etc. The fact that the event’s cause is not obscure ensures that the discomfort it causes is both predictable and fully comprehensible.
In the shock of the event, we can interpret cognitive blockage in many people as the brain shutting itself off to mental stimuli due to excessive adrenocorticotropic hormone (ACTH) and cortisol release. Later on, in other words, over-aroused state, avoidance behavior related to the event, insomnia, re-experiencing (Flashback), having nightmares are common symptoms. Even when awake, the person remembers the traumatic event over and over. S/he continues to experience the event that happened 10 years ago as if it happened yesterday. Since s/he feels like s/he is reliving the event, s/he tries to avoid the reminders.
Another definition of PTSD in DSM appears as follows: “The main feature of post-traumatic stress disorder is to experience the event of actual or threatened death, serious injury, or a threat to the physical integrity of the person, or the death or threat of death of another person. Extremely traumatic experiences, such as witnessing an event that poses a threat to one’s life, injury or physical integrity, or learning that a family member or other relative has unexpectedly died or has been killed by being exposed to violence, was seriously injured or is under threat of death or injury. The development of specific symptoms following a source of traumatic stress. The person’s reactions to the event in question are extreme fear, helplessness, or horror” [1].
Studies conducted with large populations affected by the devastating earthquake, wars, and involvement in concentration camps found PTSD development risk between 20 and 50%. In one study conducted, data were analyzed from 26 population surveys in the World Health Organization World Mental Health Surveys. A total of 71,083 respondents aged 18+ participated. The cross-national lifetime prevalence of PTSD was 3.9% in the total sample and 5.6% among the trauma-exposed [2].
The experience of trauma is by no means exceptional, with all of its disruptive, jarring, deeply traumatic, intolerable, and “extremely terrifying, helpless, or terrifying” qualities. Moreover, both the frequency of PTSD that develops after a traumatic event and the acute stress disorder that occurs immediately after the trauma is often closely related to the threat to the person’s psychological integrity.
It does not seem possible to establish a relationship between the nature of the trauma and the developing pathological picture that would require us to refer to the importance and severity of the current trauma. Of course, we should also note that different psychopathological conditions, such as post-traumatic depression and substance abuse, can occur utterly independent of PTSD. So, when we consider all these, we need to argue that the non-traumatic factors that determine the emergence of PTSD are essential enough and need to be carefully investigated [3].
It is the ontological and cultural dimension that does not attract much attention from non-traumatic factors. Believing in and taking shelter in an unseen reality that knows everything, controlling the existence of belief in God when they feel helpless, powerless, and weak increases resilience to trauma. The conception of guardian angels, the Holy Spirit, or absolute monotheism (Tawhid) can be mental-sheltering. This approach, which changes our perceptions toward resilience, is also used in third-wave psychotherapies (Mindfulness, Metacognitive therapies) [4].
When mainly dealing with why evil exists, the Theodicy discipline proposes that it is significant to attribute more positive meanings to evil instead of ascribing it as a punishment. For the Positive Psychology approach, perceptions can change in the direction of endurance. Philosophers develop more or less similar ideas. Epicurus alleges that the Gods do not interfere with the earth, so evil belongs to the Gods. The motivation to enjoy is a sufficient measure for man. Giving the example of his famous cave allegory, Plato declares that God is absolute good and this world is not real life. While Kant says that evil has nothing to do with God, Leibniz claims that evil is for the benefit of good. For Comte, if he cannot prevent evil, God is helpless.
Unlike all these thinkers mentioned above, existential philosophy accelerated ferocious competition with the proposition that “God does not exist or cannot be proven, man’s purpose is to seek self-interest and freedom in the world, and he must be selfish.” As a result, many scholars, such as Nietzsche, Sartre, Kierkegaard, and Dostoevsky, changed the purpose, meaning, and values of life formed by human values in the name of hedonism and freedom. They even found Hegel and Kant to be prescriptive. On the other hand, Karl Popper said that if there is no evidence in epistemology, falsification is required. That is, it cannot be proven that God does not exist. Analytical philosopher Alvin Plantinga, on the other hand, argued that evils are necessary not because God does not exist but because God gives free will.
Heidegger, in 1966, accepted “time” as the most fundamental ontological category in the philosophical field. Today, people emotionally become vulnerable to traumatic experiences when existentialist philosophers Camus and Sartre defend absurdism by saying there is no meaning in life. Positive psychology, for this reason, has tried to fill the gap of this meaninglessness and meet the need to search for meaning. Today, when metacognitive genes related to the search for the meaning of life are mentioned, evidence has been sought against the approach of absurdism that reduces resilience to trauma. Psychological well-being is discussed in subjective, relational, semantic and temporal, and existential dimensions. The positive psychology literature confirms the importance of psychological well-being for resilience, so ontological well-being should not be ignored [5].
Ontological well-being, apart from subjective well-being, is the evaluation of life. Here, one’s own life as a project should be examined together within the contexts of “past,” “future,” and “present.” The meaningful combination of past, present, and future is the main focus of the evaluation of life [6].
People feel the need for a solid belief. The statement, “I believe, therefore I am,” has been an area in which neuroscientists present their evidence [7, 8]. Being able to connect to that feeling in situations that one cannot control and cannot afford is considered in trauma therapies. For this reason, knowing the ontological dimension in the protection and prevention of PTSD and providing resilience training are recommended by Seligman under the name of the PERMA model.
According to the March 2021 news in New York Times, the increase of existential questioning with the effect of social trauma globally draw our attention, particularly to the establishment of “Ministries of Loneliness” in England and Japan and on the search for solutions to suicide epidemics. The Ministry of Loneliness has an important mission as the existential needs of individual members of society have to be truly met by the systems. They can open new ways for the people who face trauma and allow them truly benefit from the effects of new diagnostic and therapeutic approaches. The existence of the ministry is highly significant, particularly in the case of the suicide epidemic. It can prevent suicidal people’s feeling isolated and self-destructive action.
For this reason, studies on reorganizing the meaning of life and lifestyle have increased with the effect of social trauma. In a similar vein, Üsküdar University Senate reflected their studies and published a manifesto on Earth Day on April 22, 2021, to increase the resistance of world societies to trauma after the Pandemic and lead life toward the better tried to announce it globally. Üsküdar University here aims to help people who had a traumatic experience on a wider scale.
After the cold war, the world became unipolar. As a result, global trends toward social justice have declined. Therefore, it is necessary to avoid the emergence of a new wealth hostility and to minimize opportunity and income inequality. For this reason, it is the right place to commemorate Marx and Engels together and talk about that extraordinary passage from the Communist Manifesto:
“Wherever the bourgeoisie has taken over, it has put an end to all feudal, patriarchal, rural relations. It has ruthlessly cut off the tangled feudal ties that bind man to his ‘natural superiors,’ leaving no other bond between man and man than pure self-interest, solid ‘cash payment.’ It has drowned the divine ecstasy of religious bigotry, the chivalric spirit, and petty-bourgeois sentimentality in the icy waters of selfish calculation. He has transformed personal dignity into exchange value and has replaced the innumerable freedoms so hard-won with that single, ruthless freedom, the freedom to trade. In short, it has replaced the exploitation of hidden religious and political illusions with open, indecent, direct, and brutal exploitation.”
What will close that trauma bracket is obvious—the struggle of the poor/oppressed for liberation, equality, and freedom. Since the oppressed/poor are naked, all organizations and ties have collapsed, they are alone and helpless; since there is no light left for their hope, all ears to hear their voices are deaf [3].
As the sociopolitical consequence of the trauma, the global justice movement for worldwide peace must be initiated. We conducted a study in our field to turn trauma into an opportunity and presented it to the scientific world as evidence. In April 2020, 6318 cases were screened in all provinces of Turkey on Pandemic Fears, Anxiety, and Maturation, and there was a significant increase in six questions in the post-traumatic growth scale [9]. The primary aim of this investigation was to understand whether these findings are permanent after the Pandemic is over. These six questions are as follows:
The priority of the things I care about in life has changed, 59%
My interest in spiritual issues increased, 49%
I realized that I could handle the weaknesses, 56%
I can accept the events as they are, 56%
I started to give more importance to my social relations, 48%
I understand the value of the things I have, 74%
As a result, the causality relationship between Existence and Trauma draws attention. In addition, although 2 years have passed since COVID-19, it continues to force societies as a global social trauma. There are precursors to social crises that may occur. Such as migration and increase in mental disorders as post-pandemic. The rise of individual armament globally is worrying. We must find solutions so that there is no new break and disappointment in humanity. In conclusion, within the scope of this study, it is decided to present the aforementioned global well-being manifesto that will contribute to humanity’s search for meaning and solution. In addition to this, it is lucid that the role of social scientists here plays a crucial role. For a better world, media, social and political scientists and leaders take several factors into consideration. Their function to lead to global peace and mental health is explained further in part six.
Post-traumatic stress disorder (PTSD) is a multifactorial disease characterized by structural, metabolic, and molecular changes in various brain regions and neural circuits, such as the limbic system, hippocampal region, and prefrontal cortex (in Figure 2), which regulate neurobehavioral functions [10]. Epigenetic and genetic current studies are included in this section. PTSD can occur at the organic, cellular, and molecular level due to the effect of an external event such as psychological trauma, as well as being inherited from generation to generation. In PTSD, genetic and epigenetic studies are prioritized based on biological research because they are promising in elucidating molecular functioning and finding biomarkers. The goal of these studies is to lay the groundwork for new and preventive treatments to ameliorate the symptoms that cause the disease. In this context, there is the current evidence for the potential of current genetic and epigenetic studies from the biological risk factors of PTSD.
Current candidate genes associated with different brain regions and neuro-behaviors in PTSD [
Thousands or even hundreds of thousands of single nucleotide polymorphisms (SNPs) with a polygenic background are the genetic basis of PTSD according to Genome-wide association study (GWAS) summary statistic [11]. Considering the studies on twins with a traumatic history for hereditary dimensions, PTSD is inherited from 30% males and 70% females, SNPs play a major role in this hereditary process from women [12]. The heritability of PTSD following trauma has been demonstrated, but biological variations have not yet been fully defined. Elucidating the biological mechanisms underlying PTSD may contribute to a more accurate diagnosis and development of swelling-specific treatment interventions. Among the biological processes involved in PTSD and related conditions, this section focuses on epigenetic and genetic mechanisms. Genomic and epigenomic studies in large groups are valuable. Loci most recently examined in large-scale GWAS and Epigenome-wide association studies (EWAS) became candidate biological markers for PTSD.
Specific PTSD genetic variants that contribute to genetic studies have been most extensively researched and are currently known in the monoaminergic neurotransmission and hypothalamic-pituitary-adrenal (HPA) axis [13, 14]. The most frequently studied serotonin transporter gene (SLC6A4) polymorphisms in the monoaminergic system were associated with PTSD and identified with a prevalence of 45% in Europeans is the S allele frequency of SLC6A4. Association studies of
One of the largest polymorphism studies of the Nurse’s Health Study II, which included 845 PTSD cases and 1693 trauma-exposed controls, examined 3742 single nucleotide polymorphisms (SNPs) spanning more than 300 genes, but no gene was of clinical significance [19]. Meta-analysis and GWAS studies take an agnostic approach to the discovery of risk loci by comparing the frequencies of hundreds of thousands of SNPs and other genetic markers from the whole genome with those of controls, at least an update five gene markers are promising, including Zinc Finger DHHC-Type Palmitoyltransferase 14 (ZDHHC14), Parkinson Protein 2 E3 Ubiquitin Protein Ligase (PARK2), Kazrin, Periplakin Interacting Protein (KAZN), TMEM51 antisense RNA 1 (TMEM51-AS1), and Zinc Finger Protein 813 (ZNF813) [20, 21, 22]. The latest Military cohort study (29,539 PTSD cases and 166,145 controls) reported that Zinc Finger Protein 140 (ZNF140) is upregulated in blood, and Small Nuclear Ribonucleoprotein U11/U12 Subunit 35 (SNRNP35) is downregulated in the dorsolateral prefrontal cortex in Military PTSD [23]. Duncan et al. investigated strong evidence of overlapping SNPs and multi-loci risk between PTSD and schizophrenia (from 20,730 individuals) via 11 genome-wide case–control molecular genetic studies [24]. Chen et al. found two loci including chr10_6953246_D and rs2311207 that were associated with the severity of PTSD symptoms [25]. Other genome-wide significant loci were Ankyrin Repeat Domain 55 (ANKRD55) (rs1595))2 and Zinc Finger Protein 626 (ZNF626) on chromosome 19, moreover, the ANKRD55 gene was also related to rheumatoid arthritis and psoriasis that are additionally seen in patients with PTSD [26]. Maihofer et al. also found loci on four genes: Gamma-Aminobutyric Acid Type B Receptor Subunit 1 (GABBR1), Forkhead box protein P2 (FOXP2), Family with Sequence Similarity 120A (FAM120A), and ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2 (ARFGEF2) which had genome-wide significant (p < 5 × 10–8) from African American ancestry and the external Million Veteran’s PTSD [27]. Pooler also discovered two SNPs; rs13160949 on chromosome 5 (p = 7.33 × 10–9) and SNP rs2283877 on chromosome 22 (p = 2.55 × 10–8) which have been firstly investigated in PTSD [28]. SNP rs267943 is located on chromosome 5 in the intron of the death-associated protein 1 (DAP1) gene had the strongest association from 396 chronic PTSD patients (Thai Tsunami survivors) and 457 controls [29]. Large-scale genome studies have identified heterogeneous and numerous SNPs and genes at multiple loci. Successful polygenic prediction models can be discovered in the future by increasing the number of current and large-scale studies. Current candidate genes associated with different brain regions and neuro-behaviors in PTSD are given in Figure 2.
To better observe the Gene-Trauma Correlations in PTSD, epigenetic studies are also important to investigate the effects of environmental factors. Epigenome-wide association studies (EWAS) have identified epigenetic mechanisms for PTSD due to alteration of gene expression modifications without changing the genetic code. Epigenetic studies are carried out due to traumatic memory in the hippocampal region, frontal cortex associations, and extreme fear in the limbic system. An important regulation of gene function and phenotypic expression occurring in the understanding of PTSD occurs at the level of epigenetic regulation. Epigenetic changes include DNA methylation, histone modifications, and non-coding RNAs.
Animal research generally suggests that stress-induced epigenetic modification following environmental stress may affect stress-response functions as mediated by gene expression, HPA axis. Epigenetic factors, such as DNA methylation, have been shown to modulate the influence of the environment on gene expression [30]. McNerney et al. showed that the hippocampal volume/glucocorticoid receptor (GR) gene methylation interaction is an indicator of PTSD symptoms in 67 Veteran Patients [31]. Although animal and small sample epigenetic studies give clues about multiple genes and analysis, a major challenge for these studies is controlling the wide variety of stress factors that subjects are exposed to throughout their lives, and also they must be significant in EWAS measures. Hjort et al. reported that offspring of 72% of 117 mothers with PTSD had higher cortisol levels and differential methylation in candidate genes [NR3C1, 5-Hydroxytryptamine Receptor 3A (HTR3A), and BNDF] but the level of methylation differences did not reach epigenome-wide corrected significance levels [32]. Recent Epigenome-wide meta-analysis of military and civilian PTSD reported low DNA methylation in the four CpG regions of the Aryl-hydrocarbon repressor (AHRR) from blood DNA samples of 1896 PTSD patients [33]. Epigenetic meta-analysis of civilian PTSD (545 study participants) also found differential methylations in two CpG sites including NRG1 (cg23637605) and HGS (cg19577098) [34]. Interestingly, Yang et al. conducted two new different epigenetic biotypes for PTSD (G1 and G2). The G2 biotype has been associated with an increased risk of PTSD. The G1 biotype had higher polygenic risk scores and higher DNA methylation [35]. Logue et al. reported an epigenome-wide significant association with cg19534438 in the gene G0S2 (G0/G1 switch 2) and replicated it in other military cohorts. Although cg04130728 in Carbohydrate Sulfotransferase 11 (CHST11) had no genome-wide association, was significantly associated with PTSD in brain tissue (mostly prefrontal cortex) [36]. A longitudinal epigenome-wide association study identified three epigenome-wide significant CpGs, the intergenic CpG cg05656210 and Mitotic Arrest Deficient 1 Like 1 (MAD1L1) (cg12169700) and HEXDC (cg20756026).
Interestingly, cg12169700 was located within the same linkage disequilibrium block as a recently identified PTSD-associated (rs11761270) SNP in MAD1L1 [37]. In a meta-analytical review by Wolf et al., sex and immunity were strongly associated with the age of DNA methylation. However, they noted the lack of research into the underlying biological mechanisms [38]. In a multi-ethnic meta-analysis study (30,000 PTSD cases and 170,000 controls), non-coding RNAs such as Long Intergenic Non-Protein Coding RNA 2335 (LINC02335), microRNA 5007 (MIR5007), transcribed ultra-conserved region 338 (TUC338), (Long Intergenic Non-Protein Coding RNA 2571) (LINC02571), Long Intergenic Non-Protein Coding RNA 458 (LINC00458), microRNA 1297 (MIR1297) and Long Intergenic Non-Protein Coding RNA 558 (LINC00558) and PARK2 gene are involved in dopamine regulation, is associated with PTSD [20].
These studies support epigenetic differences in those with PTSD but it is also difficult to understand how persistent epigenomic changes affect a person’s response to a traumatic event, and specifically to the molecular landscape of the brain. For this reason, it is inevitable to encounter multiple epigenetic effects in many parts of the brain and that these have not yet found their place in translational medicine. Current epigenetic studies are focused on research on blood DNA, and analysis of postmortem data from different brain regions can be used to understand how epigenetic regulation works in PTSD at a circuit, brain region, or whole-brain level [10]. Consequently, since the biological studies of PTSD are heterogeneous, it has not yet taken its place in translational medicine for a definitive diagnosis. More research with larger sample groups is needed in the biological diagnosis and treatment of PTSD.
The paucity of human studies investigating the neurobiological mechanisms of PTSD mirrored the understanding of this disease in animal models. Dysregulations of fear and stress-focused inflammatory responses detected in various brain regions have emphasized the importance of central nervous system centers that regulate fear memories (i.e., amygdala) and in response to acute or chronic stress response (i.e., the hypothalamus) since it began to be detected in PTSD patients. While animal studies continue to investigate fear-related processes for the amygdala, the medial prefrontal cortex (mPFC) and the hippocampus, interactions of the lateral (LA) (acquisition of fear and extinction concerning learning) and central nuclei (CeA) (behavioral expression of conditional fear) of the amygdala’s nuclei regulating the inhibitory and excitatory effects of fear have been identified [39]. Connections between the hippocampus and the amygdala, particularly the LA, appear to be essential for the acquisition and reinforcement of contextual fear. At this point, it is thought that the somatosensorial projection of the hippocampus to the amygdala triggers contextual fear memory and may trigger fear-related learning through the LA nucleus. In addition, other evidence suggests that projections from the hippocampus to the mPFC can innervate neurons in the prelimbic (PL) and infralimbic (IL) regions that are active during fear and stress in animal models. PL and IL regions were important by creating neuronal potentials after the mPFC learned stress and conditioned fear on rodents, especially PL activity is responsible for regulating fear while its expression [40]. For instance, Richter-Levin developed a PTSD model in which animals are conditioned to pair a water-associated zero maze (WAZM) with underwater trauma that might be related to Amygdala LA and CeA nuclei. The remainder of underwater trauma rather than swimming stress, additional evidence of increased ERK phosphorylation (pERK) in the ventral dentate gyrus and basolateral amygdala [41]. Considering animal models of electrocution, this model is used more in learning and memory mechanisms than in PTSD, although it is associated with contextual reminders of trauma (associative fear) and ambiguous stimuli in a new setting (non-associative fear). Likewise, single long-term stress patterns were associated with neuronal apoptosis and dysregulation of autophagy in the hippocampus, amygdala, and prefrontal cortex (PFC), consistent with the findings in PTSD patients in terms of neurobiological background [42]. The social and psychological stressors animal model was mostly used for the PTSD behavioral measurements. In contrast, the social defeat stress (SDS) model was associated with optogenetic modulation of neuron projections to/from the ventromedial prefrontal cortex, ventral tegmental area, nucleus accumbens, and dorsal raphe nucleus in parallel with the PTSD clinic. Interestingly, amygdala-mPFC neuroadaptation was discovered in resting-state functional magnetic resonance imaging (rsfMRI) findings from Long-Evans rats exposed to the cat collar in predator-associated animal models [43].
Serotonin (5-HT) is an important neurotransmitter for PTSD, targeting GABAergic neurons in response to fear-related acute stress in the amygdala, hippocampus, and ventromedial prefrontal cortex (vmPFC) regions. Clinical and animal studies have shown that symptomatic reduction associated with the use of antidepressants and/or anxiolytics in the treatment of PTSD is associated with stimulation and interaction of 5-HT1A, 5-HT1B, and 5-HT2A or 5-HT2C receptors. Sullivan et al. demonstrated positron emission tomography (PET) results of PTSD-like animals found higher 5-HT1A neuronal binding in all brain regions except the hippocampus and higher serotonin concentration in raphe nuclei compared to the healthy group [44]. Murrough et al. showed low 5-HT1B receptor density in the amygdala and anterior cingulate cortex (ACC) in PTSD patients [45]. The majority of the overactive noradrenergic activity associated with PTSD is due to the interaction of peripheral catecholamine (epinephrine, norepinephrine, and dopamine), transporter and receptor systems. In an animal and replicated study in humans, the high synaptic activity of norepinephrine (NE) in PTSD patients was detected in PFC projection areas. NPY also inhibits NE release and is found in high concentrations in the hippocampal and amygdala regions, it is associated with the projection of emotional values to memory and plays a role in the neurobiology of PTSD. Although intranasal NPY treatment reduces symptoms in many animal models of PTSD, efforts to develop NPY receptor-related pharmacological agents have failed [46]. Glutamate is an integral part of the learning, memory, and plasticity process. The glutamatergic system is studied as ionotropic and metabotropic. The PFC is transferred from the other to the amygdala and the bases of the whole brain regions to the amygdala are transmitted by glutamatergic contents and abnormal glutamate levels in PFC and N-methyl-D-aspartate (NMDA) receptor density in the hippocampus that is associated with synaptic plasticity underlying learning and memory, also have been reported in acute stress animal models. Especially metabotropic glutamate receptors have related with PTSD symptoms, high glutamate levels in the lateral temporal cortex and lower levels in ACC have been demonstrated. Research is ongoing that injection of subanesthetic doses of ketamine into rat brains increases glutamatergic neuronal activity in the PFC, which NMDA antagonists trigger learning and fear-related plasticity when examining the link between the glutamate system and dissociative symptomatology. Animal studies have shown that ketamine administration increases glutamate neurotransmitter levels and thus stimulates BDNF signaling, neurogenesis, and synaptogenesis [47]. GABA plays an important role in spatial and long-term memory, and directly in fear memory, in relation to neurogenesis in the hippocampal region. Fang et al. reported increased dysregulation of anxiety and fear memory with increased active GABAergic neurons in the CeA region of the amygdala in the single prolonged stress (SPS) animal model [48]. Behind the neurobiological mechanisms of PTSD, neuronal cell membrane damage due to stress and fear has also been researched. This damage is usually caused by oxidative stress-related free radicals (reactive oxygen species, for example, nitric oxide, glutathione, and hydrogen peroxide) damage to the cell membrane. In a recent study, Michels et al. found high higher levels of γ-amino butyric acid GABA and glutathione in PTSD patients via single-voxel proton magnetic resonance spectroscopy (MRS) in the dorsolateral prefrontal cortex (DLPFC) and ACC [49]. PTSD is also related to abnormal activity of the dopaminergic system, which has a mesolimbic pathway that is related to fear conditions and high plasma dopamine concentration was reported in PTSD patients. However, the dopamine metabolism of PTSD is unclear, so the genetic background is more studied. Most of these neurobiological explanations are accompanied by synaptic losses underlying PTSD. The clinical behavioral reflections (i.e., social disinhibition, apathy, attention and memory disorders, etc.) of these synaptic losses in various parts of the brain are tried to be explained. As a result of stress, disruption of intracellular signaling may result in a decrease in glutamate receptors and shrinkage of dendrite horns in postsynaptic neurons. The synaptic degeneration hypothesis is the basis of many neurodegenerative psychiatric disorders. Results of a postmortem pilot study reported that PTSD patients were immature, as the dendrites evaluated in vmPFC tissues were smaller in their spines compared to the control group [50]. In addition, neuroimaging studies conducted in PTSD were associated with volumetric and neuronal connectivity deficiencies in cortical areas and their resulting loss of cognitive functions in PTSD clinics. In particular, losses in dendritic connections are predominantly in hippocampal regions associated with neuroplasticity, resulting in chronic or acute stress-related learning disabilities. In short, the perspective on neuroplasticity has been developed by investigating neurochemical and receptor interactions in various brain regions of PTSD. In this context, antidepressants used clinically for PTSD may contribute to clinical improvement by promoting synaptic plasticity with this neurobiological infrastructure. In addition, inferences about synaptic connectivity based on neuroimaging methods are still unclear but may reveal various risks. Due to the limited knowledge about the neurobiology of PTSD, the inadequacy of the findings from animal stress models for the pathophysiology prevents us from making definite conclusions about the clarity of the applications for the clinical treatment of this disease. As a result, PTSD has been scientifically investigated with behavioral consequences related to neurobiological, genetic, and epigenetic, literature discussions continue especially in terms of both neuroscientific and clinical aspects. The importance of neurochemical, biological, and brain-regional neurologic interactions in human and animal models remains a mystery, and further studies need to unlock this mystery.
A cluster of psychiatric symptoms that persist for more than 1 month following a trauma, causing distress or a decrease in functionality in social, occupational, or other important areas of life is called PTSD [51].
Self-alienation (depersonalization): persistent or recurrent experiences in which the person feels detached from his mental processes or body, looking at them as if he were an outside observer (e.g, the sensation that he is in a dream; the sensation that he or his body is unreal, or that time is running slowly).
Unreality (derealization): persistent or recurrent experiences of feeling that the world or environment around the person is unreal or somewhat distorted).
In the face of severe stress, information processing is impaired, and it is not possible to resolve the traumatic event. An unintegrated traumatic experience can be easily aroused and affect daily life. Painful experiences cannot be suppressed or excluded. In experiences recorded with anxiety/fear, stimuli that stimulate one of the emotion-thought elements activate all of them. This general arousal and the unorganized cognitive processing behind it are considered as the source of symptoms, such as arousal, memory disorders, and impulsivity in PTSD. The individual who encounters the trauma first experiences confusion. This unprepared/unconditioned situation changes in the next step. By using the lived experiences before the trauma, the trauma is perceived as if it had been encountered before. The same emotional and physical reactions are given in the previous cases. This is a highly learned behavior. However, since this behavior is not suitable for the new situation, it is not an appropriate response and the answers become complex. Increasing confusion also increases anxiety. To diagnose PTSD, valid, objective/empirical methods other than previous trauma have not been defined. The diagnosis depends on the clinical interview. The use of check-lists without recourse to clinical interviews may lead to the loss of significant clinical information that may be essential in the holistic provision of therapy and clinical care. To be diagnosed with PTSD, an adult must have all of the following for at least 1 month after a traumatic event: At least one re-experiencing symptom, one avoidance symptom, two arousals, and reactivity symptoms, and two cognition and/or mood symptoms.
The Post-traumatic Stress Disorder Checklist for DSM-5 (PCL-5) is a self-report measure to evaluate the presence and severity of PTSD symptoms (Table 1).
In the past month, how much were you bothered by: | Not at all | A little bit | Moderately | Quite a bit | Extremely |
---|---|---|---|---|---|
1. Repeated, disturbing, and unwanted memories of the stressful experience? | 0 | 1 | 2 | 3 | 4 |
2. Repeated, disturbing dreams of the stressful experience? | 0 | 1 | 2 | 3 | 4 |
3. Suddenly feeling or acting as if the stressful experience were actually happening again? | 0 | 1 | 2 | 3 | 4 |
4. Feeling very upset when something reminded you of the stressful experience? | 0 | 1 | 2 | 3 | 4 |
5. Having strong physical reactions when something reminded you of the stressful experience? | 0 | 1 | 2 | 3 | 4 |
6. Avoiding memories, thoughts, or feelings related to the stressful experience? | 0 | 1 | 2 | 3 | 4 |
7. Avoiding external reminders of the stressful experience? | 0 | 1 | 2 | 3 | 4 |
8. Trouble remembering important parts of the stressful experience? | 0 | 1 | 2 | 3 | 4 |
9. Having strong negative beliefs about yourself, other people, or the world? | 0 | 1 | 2 | 3 | 4 |
10. Blaming yourself or someone else for the stressful experience or what happened after it? | 0 | 1 | 2 | 3 | 4 |
11. Having strong negative feelings, such as fear, horror, anger, guilt, or shame? | 0 | 1 | 2 | 3 | 4 |
12. Loss of interest in activities that you used to enjoy? | 0 | 1 | 2 | 3 | 4 |
13. Feeling distant or cut off from other people? | 0 | 1 | 2 | 3 | 4 |
14. Trouble experiencing positive feelings | 0 | 1 | 2 | 3 | 4 |
15. Irritable behavior, angry outbursts, or acting aggressively? | 0 | 1 | 2 | 3 | 4 |
16. Taking too many risks or doing things that could cause you harm? | 0 | 1 | 2 | 3 | 4 |
17. Being “super alert” or watchful or on guard? | 0 | 1 | 2 | 3 | 4 |
18. Feeling jumpy or easily startled? | 0 | 1 | 2 | 3 | 4 |
19. Having difficulty concentrating? | 0 | 1 | 2 | 3 | 4 |
20. Trouble falling or staying asleep? | 0 | 1 | 2 | 3 | 4 |
The PTSD Checklist for DSM-5 (PCL-5) [54].
Criterion B (1–5)—at least one ≥2 Criterion C (6–7)—at least one ≥2 Criterion D (8–14)—at least one ≥2 Criterion E (15–20)—at least one ≥2.
Mild 0–20; Moderate 20–40; Severe 40–60; Extreme 60–80.
Inability to explain and share the effects of trauma, severity, and frequency of dissociative reactions during or immediately after trauma, childhood physical abuse, genetic predisposition, family history of psychopathology and PTSD, being a woman, excess physiological response during the traumatic event, acute stress disorder and early PTSD symptoms, previous psychiatric disease history, low socioeconomic level, and low education level, temporal intensity, and duration of trauma, memory disorders, soft neurological signs, low IQ , childhood attention deficit hyperactivity disorder symptoms are the factors related with increased risk or chronicity of PTSD [52].
PTSD is associated with many comorbidities besides causing disability on its own. Major depressive disorder, generalized anxiety disorder, alcohol and substance use disorders can be listed as the main comorbid conditions. The high-stress level accompanying PTSD increases the risk for many systemic diseases, such as hypertension, diabetes, and asthma [55].
One of the important comorbidities of PTSD is a borderline personality disorder. Borderline personality disorder causes the person to become prone to experiencing traumatic events by distorting the perception of risk. On the other hand, PTSD symptoms deepen the loss of functionality associated with a personality disorder.
If PTSD symptoms are present within 3 months following the trauma, it is defined as acute PTSD; and if symptoms persist for more than 3 months, it is defined as chronic PTSD [55].
PTSD is single-event trauma from traumatic experiences, such as rape, physical assault, or war. However, the traumatic event might be prolonged chronic victimization, such as interpersonal violence. Over time, chronic traumatization, often of an interpersonal nature, such as multiple and/or long-term developmentally negative traumatic events, came to be used to describe the term “complex trauma” [56].
The clinical course and outcome of PTSD vary depending on the factors before, during, and after the trauma. The nature of the symptoms observed after trauma, the prognosis of the disease, or the information obtained from follow-up studies conducted at different periods makes it difficult to define a specific clinical situation for the course of the disease. PTSD starts when trauma is encountered or within the next few years, symptoms increase in the next few years and continue by drawing a plateau. Symptoms may fluctuate over time and intensify during stressful periods. Approximately 30% of patients show complete improvement, 60% have mild to moderate symptoms, and 10% have symptoms that remain unchanged or worsen. It is common for those who benefit from treatment to reappear after years of being exposed to a serious stressor.
Several neuroimaging studies have been implemented to investigate the pathophysiology of PTSD. Some symptoms associated with PTSD are related to changes in brain structure and function [57]. Brain regions implicated in the development of PTSD include the hippocampus, amygdala, and medial prefrontal cortex [58].
Advanced neuroimaging techniques contributed to our understanding of the possible pathophysiology of PTSD. The results of neuroimaging studies point to the importance of the hippocampus in PTSD. Exposure to chronic stress results in disturbances in memory function and neural damage to the hippocampus. The HPA axis controls stress response in the body by producing cortisol. The neural damage might be related to high levels of glucocorticoids, changes in serotonergic function, inhibition of neurogenesis in the hippocampus, or inhibition of brain-derived neurotrophic factors [59].
The magnetic resonance imaging (MRI) studies in PTSD consistently revealed reduced hippocampal and inferior temporal cortex volumes. The decreased volume of the inferior temporal cortex was inversely correlated with anxiety levels in PTSD [60]. Other neural structures often implicated in the pathophysiology of PTSD include the amygdala and prefrontal cortex. Amygdala is the integrative center for emotions, emotional behavior, and motivation. Functional magnetic resonance imaging (fMRI) studies with PTSD patients present increased activity in the amygdala in response to threat stimuli compared [57]. However, investigation of a large sample of nearly a hundred PTSD patients was characterized by reduced amygdala volumes [61].
Several methods have been used to study the pathophysiology of PTSD. Many neural networks and pathways that play a role in PTSD have been revealed, and these pathways can be studied in-depth due to the advances in techniques for neuroimaging.
PTSD is associated with functional impairment and comorbidity. Therefore, early diagnosis and appropriate treatment are essential in PTSD. Existing treatment guidelines for the treatment of PTSD disorder generally aim to—reduce PTSD symptoms or achieve remission, loss of diagnosis, treatment of comorbid medical and psychiatric diseases, improvement of quality of life, correction of impairment in functional areas, return to work or duties. Treatment guidelines include psychological, pharmacological, and neuro-modulatory treatments [55]. However, a major limitation must be recognized: the current therapies described for PTSD are based on western cultures and modern technologies, and many of these approaches do not easily apply to rural communities in low- and middle-income countries. Clinicians or psychotherapists should, therefore, adopt psychotherapeutic strategies that are appropriate to the cultures in which they work.
It includes the use of various psychotropic drugs to target the core symptoms of PTSD. Medications that target key symptoms of PTSD, including intrusions, avoidance, negative changes in cognition and mood, and changes in arousal and responsiveness, include selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, atypical antipsychotics, β-blockers, and sleep medications (e.g., α-blockers, nabilone, hypnotics). Pharmacological treatments include antidepressants (e.g., sertraline), antipsychotics (e.g., risperidone), anticonvulsants (e.g., topiramate), hypnotics (e.g., zopiclone), and mood stabilizers (e.g., lithium), mood stabilizers; adrenergic agents; benzodiazepines; and other pharmacological agents [55].
Selective serotonin reuptake inhibitor (SSRI) stands out among pharmacological treatments because it is effective in most PTSD symptoms, easy to use, and has low side-effect profiles. They are the most valid and widely used drugs for the treatment of re-experiencing, avoidance, emotional blunting, and hyperarousal symptoms. SSRIs have been found to be effective in PTSD in double-blind, placebo-controlled randomized trials.
Mood stabilizers have the effect of reducing the sensitization of the limbic system, which develops in the first weeks and months after the traumatic event. Lamotrigine was found to be effective in re-experiencing and avoiding symptoms of PTSD. Studies are reporting that lithium, valproic acid, carbamazepine, oxcarbazepine, and gabapentin are effective. It has been found that propranolol, a beta-blocker, has positive effects on nighttime nightmares, remembering repetitive anxiety-provoking situations, jumping, sleep disturbances, and self-esteem.
Psychological treatments for PTSD are mainly in the form of cognitive-behavioral therapy. Cognitive processing therapy, trauma-focused cognitive behavioral therapy, and long-term exposure are largely within the framework of cognitive and behavioral therapy. Among the Cognitive Behavioral Therapies, especially Exposure Therapy and Systematic Desensitization techniques are successful in trauma treatment. In both techniques, it is aimed to desensitize the person and gradually reduce the traumatic effects by enabling the person to face the images and situations related to the trauma in a systematic and controlled manner.
Interpersonal psychotherapy was also found to be promising in recent research. Interpersonal psychotherapy is a form of attachment-based therapy. The patient is shown his / her own needs, and the support he/she needs. The client is taught how to get the support he/she needs from those around him/her. Thus, he/she will be able to recognize the attachment needs that have become active due to the trauma and will be able to provide appropriate social support for himself/herself.
During the traumatic event, the individual is exposed to intense fear and anxiety. The traumatic event cannot be processed by the brain as it should. The traumatic memory, which cannot be processed adequately and appropriately, disturbs the individual over time. Eye Movement Desensitization and Reprocessing (EMDR), developed by Shapiro and used in the treatment of PTSD, activates both halves of the brain through two-way eye stimulation and ensures healthy processing of the traumatic memory. With the EMDR method, the traumatic memory with high emotional intensity for the individual loses its vitality and the individual’s hypersensitivity disappears.
Neuro-modulatory treatments are viable treatment options for many psychiatric disorders. After U.S. Food and Drug Administration (FDA) approval of transcranial magnetic stimulation (TMS) as an option for treating depression, researchers also tried to use repetitive transcranial magnetic stimulation (rTMS) for depressive symptoms of PTSD [62]. rTMS and transcranial direct current stimulation (tDCS) are frequently employed as adjunctive options to pharmacotherapy for the treatment of several psychiatric disorders including PTSD. Several studies also investigated the potential of rTMS and tDCS in the treatment of PTSD to decrease the overactivity of the amygdala. The results of the studies revealed that both high-frequency and low-frequency rTMS can significantly reduce PTSD symptoms. rTMS may, therefore, be an effective add-on treatment option for treatment-resistant PTSD [63].
Deep TMS is a drug-free and non-surgical intervention, it does not require anesthesia. During the application, the patient is awake and conscious. The target area in the brain is physically stimulated by sending magnetic pulses under the skull with a mechanism placed in the skull. Thus, neurons working with electrical activity are activated by magnetic stimulation. It has been reported that recalling traumatic memories with activation and talking about it in the presence of an expert significantly reduces the burden of trauma.
The treatment method, which is based on the electrical processing of the data of the brain and bodywork and presenting it as feedback to the person, is called neurobiofeedback training. Thus, the patient learns to consciously control his/her own brain activity and bodily functions, such as breathing, muscle tension, and heart rate. Promising results are obtained in PTSD with the use of neurobiofeedback together with pharmacotherapy and psychotherapies.
Human development starts from conception and continues until the end of life. Along this developmental pathway, earlier years witness the highest speed and the most complex changes. Moreover, recent neurological research studies have concluded that the human brain is the fastest developing organ in the first years of life. Not only physically that the child’s brain reaches its almost full size by age four, but also by making almost 700 million snaps connections every second completing at least 80% of its functioning capacity. This makes neurological development the most decisive developmental process in the early years [64]. It also points to the fact that ACE become the major cause of long-term emotional problems, including PTSD.
Worldwide, children are often exposed to serious traumatic events, such as war, displacement, famine, and violence, that all disrupt a child’s secure family structure and lead to long-term stress. Mental health problems affect around 10–20% of the child population worldwide [65]. Trauma is common in children and adolescents and may lead to PTSD. PTSD refers to maladaptive responses to at least one severe, threatening event (serious injury, threatened death, or sexual violence) by DSM-5, and the stress response, emotion regulation problems, and threat learning are indicated as common diagnostic symptoms of PTSD are; intrusion, avoidance, negative alterations in cognition and mood and arousal [66]. These cognitive symptoms have led researchers to examine the neurodevelopmental dimension of PTSD in the light of neuroscience studies.
According to the recent neurodevelopmental research results psychological as well as physiological responses to traumatic events such as being unable to bond with primary caregiver might lead to trauma having a long-term neurological impact on a child’s psycho-social development and neurological functions [67, 68]. Such psychological problems, referred to as PTSD, are often associated with multiple psychosocial problems ranging from delinquency, poor academic performance to, alcohol and substance abuse, and even to suicidal attempts. Moreover, children exposed to traumatic events will have emotional, social, and physical developmental problems later in life [69]. It was observed that children exposed to traumatic events performed lower performance on cognitive and intellectual abilities than the children without a diagnosis of PTSD [70]. Besides, according to research results verbal and nonverbal intellectual capacity, mean IQ scores, language delay, sensory processing, memory, aggressive behavior, visual processing, affect, and behavior problems can be seen in children [71].
Neuroimaging research with PTSD indicates both functional and structural abnormalities in the front limbic area responsible for emotion regulation and threat processing. Such as decreased gray matter volume in ventromedial prefrontal and dorsal anterior cingulate cortex seen in structural analyses and hyperactivation of the insula, amygdala, and mid anterior cingulate cortex, smaller frontal-occipital circumference seen in functional analyses [72, 73]. Both structural and functional differences are also observed in the prefrontal cortex and limbic system (hippocampus and amygdala). Therefore, memory, emotion and excite function problems may accord exposure to stress [74].
Most recent scientific studies on brain development reveal the fact that early experiences shape the architecture of a child’s brain having a long-term impact on a child’s social and emotional well-being [1]. A child’s social, cognitive, and emotional development is heavily dependent on the quality of interaction between child and “significant” adult (e.g., mother, father. Caregiver. whoever s/he is bonded with). Neurodevelopmental studies claim that bonding problems and parenting inconsistencies might cause long-term mental health problems [75]. Although, the first years are critical for life-long success and healthy physical and mental development for the rest of their life, having a baby makes a significant change in the lives of parents. Lower stress of families is associated with lower stress levels and normal brain development in children [76].
Neurological development of the brain does not take place in a vacuum nor by itself. It is highly dependent on external stimulations and interactions. In other words, a child’s early experiences shape the brain architecture from the beginning [1] and leave footprints that last a lifetime. Brain developmental functions also have critical moments providing “windows of opportunities” or challenges for specific developmental pathways (Figure 3).
Human brain development [
Among all critical and sensitive periods, the first 3 years of life seem to be the most critical for emotional control responding to positive as well as adverse experiences as demonstrated in Figure 4 [77].
Sensitive periods in early brain development [
Human brain development takes more years to reach maturity compared to other species. Although this long way to maturity is adaptive for the human species, the adolescent period is the second most important part of this journey of maturity because of its adaptive values of plasticity [78]. Therefore, the adolescent period is also sensitive and critical for stress factors. According to research about brain development, it claimed that exposure time to stress plays an important role in brain structure, the adolescent stage is more vulnerable to stress compared to the adulthood stage of development.
Adverse childhood experiences (ACE), as demonstrated in Figure 5, can disrupt neurodevelopment causing social, emotional, and cognitive impairment in children that lead to the adoption of health-risk behavior leading to adulthood illnesses including cardiovascular diseases, sleep disorders, obesity, and the like [79].
Mechanisms by which ACE influences health and well-being throughout the lifespan [
Toxic stress is known as one of the most ACE in leaving almost irreversible damage in a child’s brain as given in Figure 6.
Persistent stress changes brain architecture [
Weems’s model, based on evolutionary presentative, emphasizes that the stress may lead to delay, accelerate, or prolonged developmental process according to the adaptive importance of these changes. According to the model, the developmental timing of stress exposure plays an important role in how the brain responds to the stressor, also they claimed that age and maturation are critical for amygdala volumes, which are responsible for emotion regulation [80]. Also, it is known that the prefrontal cortex and amygdala connection develop through childhood to adulthood and become stronger [79].
Coping with stress, if the stress is moderate level, is important for the healthy development of children and adolescents. In contrast, if the stress level is high, long term, and hard to cope with it, may cause damage to brain structural development, which is called toxic stress. Toxic stress defines as the activation of the human body’s stress reaction system frequently and hardly reacting to long-term stressful stimuli or long-term activation of stress response to a stressful event with a failure of the human body. Toxic stress may cause prolonged physiologic and psychologic abnormalities, such as organ dysfunction or brain functional abnormalities. Abuse, violence, neglect, food scarcity are common types of toxic stress sources All these sources can also be considered as risk factors in the development of PTSD.
Toxic stress also negatively affects the neuroendocrine-immune system. Such abnormalities on cortisol levels might also be observed. Moreover, toxic stress preventing neural connections can have an adverse impact on brain architecture that impacts planning, reasoning, emotional and behavioral control areas. It is also claimed that these responses may play a role in psychopathological disorders including psychosis, depression, and PTSD [81].
Parenting style is considered as one of the major factors having an impact on the psycho-social development of young children as well as adolescents. It is known that parenting style plays an important role in the etiology of psychopathology in children and adolescents, both as a genetic factor and an environmental factor from a transgenerational perspective [82]. Parenting style can also be a protective factor when it has a positive role, whereas when it has a negative role, it is considered as a risk factor for the development of psychopathologies, such as depression, anxiety, obsessive-compulsive disorder, and schizophrenia. Also, according to evocative gene-environment correlations, symptoms of adolescent psychological disorders may affect parental psychological status [83]. Further, some studies have found that attachment styles are associated with both psychopathological and cognitive problems in adolescents, such as psychosomatic complaints, anxiety, verbal aggression, attention-seeking behavior, and thinking problems [84]. In conclusion, exposure to the traumatic event, negative parenting attitudes, or negative attachments may also have a negative effect on brain development.
All these developmental risk factors, evaluated from an evolutionary perspective, adaptational sensitivity in both young children and adolescents, from the perspective of toxic stress, exposure to toxic stress in the early developmental period, from the perspective of family attitudes, children growing up in an overprotective or authoritarian and inconsistent family structure, when faced with traumatic stress, are all considered risk factors for developing PTSD.
Developmental models of PTSD argue that an individual’s biological, cognitive, and psycho-social characteristics are more decisive factors than the traumatic event itself in the emergence of PTSD. Such PTSD models, pointing to the importance of developmental processes of each individual argue that the brain will be affected by the traumatic event in a neurodevelopmental state. Likewise, it is thought that the neurodevelopmental state of the individual’s brain is an important determinant in the development of PTSD reacting to the traumatic event.
According to neurodevelopmental research, the duration, intensity, timing of a traumatic event is important on how the brain and development will affect the event. Also, genetic vulnerabilities may affect the damage size, such as a genetically vulnerable child may develop psychopathology while a hardier child may not [73].
Preventing, early intervention and rehabilitation techniques are important for protecting the child from PTSD effects, especially neurodevelopmental damages. If possible, preventing children from possible traumatic experiences should be the first step. Later, for children who have been exposed to the traumatic event, early intervention and immediate action to remove the child from the traumatic environment should be the second step, finally, rehabilitation, such as psycho-social support mechanisms and programs, plays an important role in preventing neurodevelopmental damages. As a promising research Nelson et al. [85], studied with 136 abandoned children to examine their brain development, cognitive functioning, social and physical growth with 12 years’ study. According to results, compared with children in foster care, the institutionalized children showed severe impairment in IQ and brain development, along with psychological disorders [85]. This study confirms that even if the child is exposed to a traumatic event, immediate action to remove the child from the traumatic environment afterward supports the reduction of traumatic effects and abnormal brain development.
The hegemony of the digital culture has changed and transformed the structure of society dramatically. The characteristics of those changes have a snowball effect on the layers of society. It is presumed that when people change, so are immediate consequences, and impacts are followed. The transformation of society ultimately dominates the way we think, feel, behave, and the way we use language. Nevertheless, the concepts, terminologies, and issues that are used in the present academia are now much more blurred compared to the clarity of the old modern days. Hence, creating a common and mutual language is plausible to comprehend the mental problems and the society with inclusive perspectives and views of digital habitus. Keeping all these digital reformations in mind, scholars try hard to keep pace with stunning developments. It seems inevitable that all academic references and mental archives should be re-read and digested accordingly.
For the well-being of public health, traumas should not be confined to individual levels. People in all walks of life are likely to suffer from PTSD. On a much broader scale, to help the victims of PTSD, diagnosis and therapy alternatives can be presented to society as a whole. If new diagnostic and therapeutic approaches regarding PTSD cases focus solely on personal levels, psychiatrists can easily fall into the trap by ignoring its widespread effect on society and on the culture of the individual that s/he lives. It is, therefore, significant to design unique therapy alternatives for PTSD patients by taking the cultural, social, and geographical facts into account. In addition to these alternatives, the experts should focus on cultural differences as well as individual differences. For example, the socio-cultural development in Turkey is in an eclectic form where the transition process from the traditional to the modern and postmodern period does not work in line. For this reason, the specific conditions of Turkish society and culture should be taken into account in social interpretations of individual problems.
Owing to the particular reasons mentioned above, social psychiatry should work for the benefit of the whole society counting PTSD patients. It is a challenging standpoint to offer a therapy that can work for the whole society. In the PTSD context, if social psychiatry utilizes cutting-edge approaches by wisely utilizing the technological advances of the cyber era, the mental and social well-being of society can be reached. It is, therefore, recommended to use new communication media, such as webinars, supervisions via the Internet, mental health apps, and developing “mind wares”. These new discourses will automatically maximize the impact of social psychiatry particularly for PTSD cases [86].
Media and television have a dangerous role as they can easily traumatize and continually retraumatize people with the vivid and graphic and horrifying pictures and videos that are broadcast on newscasts. They usually warn before they expose people pictures and videos full of violence. This is media violence. This warning cannot prevent people from trauma. So, they keep traumatizing people visually. Almost less than five decades before the digital reformation took place, George Gerbner, proposed in his Cultivation Theory that television negatively affect the mind of people [87]. TV news and programs usually exaggerate the violence of the outside world and depict the whole world as a bad, mad and cruel one. When particularly old people are exposed to media too long, they start to perceive the world as full of traumas, chaos, and tragedies. This is called Mean World Syndrome. As a result of that syndrome, three types of behavior or mood appeared: aggressive, depressive, and escaping. Unlike the world in which Gerbner lived, mass media today diversify with new technological opportunities within digital systems and affect the social sphere in a much shorter time and on a larger scale. While it is necessary to find an extra effort and time to encounter the mass media of the modern era, such as watching television, in the postmodern era, digital forms of communication tools have infiltrated the fabric of daily life. Now, without a special time requirement, individuals encounter multi-media messages in any part of daily life.
This infiltration of media in postmodern culture leaves us nowhere to escape. The risks of trauma are now scattered everywhere. Simmel associates the identity and mental problems of modern society with the over stimulus in the city life in his article Metropolis and Mental Life [88]. Whereas, in the postmodern age, we face a shift of paradigms as the rules of the game had changed. In the postindustrial society, identity and mental problems have different characteristics. Bernard Stiegler has correlated emotional problems with the digital revolution, as an inundation that carries with traumas, or at the very least the tensions.
The tsunami-like transformation of the communication landscape caused the sharp transformation from modern life to Information society that largely affected identity formation as the fragmented and episodic one [89]. People, for example, lost their feelings of belonging, and even their authentic ideology amidst uncertainty, which can be defined as social autism. The reasons highlighted here doubled the burden of psychiatrists in the post-capitalist/post-truth era. Conventional therapies, therefore, can miss embracing the overwhelming realities that those people experience.
Digital media are now full of spiritual platforms providing solutions for people in trouble or suffering psychological disorders. There appeared new types of narration that quickly become popular in cyberspace. Some approaches like collective healing streams which offer to heal the past wounds of the society may have genuine reasons and philosophy behind them [90]. However, they are not free from problems. Disinformation is ubiquitous and misleading. Therapy-based applications and contents addressing PTSD are largely held in esoteric and unprofessional ways. Unfortunately, their popularity can be hazardous and confusing regarding a large number of PTSD cases.
When the whole world was haunted by the chaotic and sudden emergence of the COVID-19 pandemic, people were not ready to cope with this storm fully. This chaos and crisis have their unique problems. Many people suffer from that not only because they try to avoid being infected but also to escape from the harsh and odd situations that affected them mentally. It seems that it is hard to find isolation from this undefined fear atmosphere for everyone. People from all walks of life have suffered from the burden of digital works, ambiguity, and economic recession. As Chul Han discusses in
In these dark times, Turkish popular media resort to products that contain psychological consultancy contents. Here we come across a newly fledgling genre about digital media that works for Psychological Consultancy [93]. Some digital therapy contents, for example, act like postmodern witchcraft as they underestimate the real role of designing a therapy. These forms, which are grown in popular culture, also have an important function in maintaining the capitalist system. Expertise knowledge in the improvement of life created a new field outside of scientific knowledge and created a mystical field in postmodern culture. In places where modernization of society does not develop well, these forms of knowledge replace rational and scientific knowledge and present themselves in a form of reality.
Therefore, it takes professional psychiatrists to end this widespread cacophony and reverse the negative situation to positive ones [94]. If wisely used, digitalization gives several opportunities to implement new techniques regarding PTSD cases. Digital therapy sessions, awareness-raising activities can reach millions of people online. People can take online therapies or watch videos related to their problems. This is the natural outcome of the advent of the Internet and changing communication environments that widen the possibilities of civil protection services and emergencies [95].
As stated earlier in the study, changes in society challenge psychiatrists to diagnose and offer therapy by adding new perspectives to their conventional practices. Psychiatrists’ role has changed as they now have to adapt these changes into their therapeutic diagnosis to follow the recent changes in society and find proper treatment. The pros of advanced technology should be used for the benefit of the people on the whole. It is true, digitalization challenges the psychiatrist to take PTSD cases by taking and addressing full sides of problems but digital narration opportunities allow them to lead fresh approaches in their discourse. Bennegadi, here, throws further questions: “Does the presence of a digital tool complicate the notion of empathy? Is confidentiality guaranteed? Is nonverbal language considered? And finally, how do we define the role of digital as a transitional element in the relationship?” [86]. The frame of these questions indicates that this is just the beginning of a new era. The methodology and their discourse that are shaped by the hegemony of the digital habitus must be arranged to offer the maximum of possibilities to the citizens in the art and the way of preserving their well-being.
Social media has been described as a double-edged sword. Beck’s suggestions about The Risk Society have lost their validity. It is apparent that the types of risks that modern societies experience should be adapted to the de facto of the Information society. The risks are now scattered everywhere. There is no secure shelter in Information Age where people hide and protect themselves. The possibility of surviving without experiencing trauma is now a dream [96].
Bourdieu as the father of the term habitus declared that human beings are conditioned by their habitus [97]. Information society now created the term digital habitus where people now have to learn how to express constellations of new or previously unrecognized feelings, sensations, thoughts, and traumas to build an emotional repertoire, which assists them in emotional regulation. This is important because naming and expressing new experiences allows people to claim convenient agency in dealing with them.
To survive in the cyber world, we need to ensure that are we corresponding. Emotional and social attachments can create our little hells. Therefore, Attachment Theory can be reread to prevent dangerous attachments that can take place in digital areas. Attachment theory signifies the importance of our social interactions among trusted ones. In a similar vein, social baseline theory argues that social relationships play an important role in the well-being of society. Attachment theory argues that many people internalize attachment representations, such that mental representations of attachment figures acquire comparable soothing effects. So we humans learn from an early age to seek refuge in trusted others in times of need; caregivers provide us with food, nurture, and protection when we are vulnerable [98].
Susan Sonntag underlines the importance of a basic human trait, such as empathy, in her book
While the general loss of meaning in the social field drags the mass into a sense of numbness, the tragedy, chaos, or violence experienced in the social field disappears without the slightest effect on the individual. This seemingly numbing state allows the legitimation and spread of violence as an impulse on every individual who constitutes the social sphere. In the social sphere, the individual gradually becomes the dynamo of a mechanism that produces or legitimizes violence, while the normative sphere of the society recedes. Reading, interpreting, and using technical tools from a critical perspective without being fetishized in the digital society will protect individuals from the possible negative effects of these tools.
When the September 11, 2001 attacks happened in New York, the collapse of the buildings and their visuals shocked the whole world. People who watched the planes plunging into the towers witnessed the commencement of a new era. This new era showed the vulnerability of the security of systems. Here, as explained above by Baudrillard’s terminology implosion of meaning, people who watched the shootings of collapsing and jumping people from the towers are appalled by the heaviness of the tragedy. They were emotionally paralyzed. Feeling acedia or aphasia are two similar traumatic outcomes when exposed to violent visuals. As we can see, continual exposure to a persisting stress source or income has created new types of patients who have PTSD. To put in other words, PTSD in the postmodern society is the outcome of the post-modern city life we all witnessed.
To make things worse, capitalism eliminates the possibility of building a healthy community to get rid of the troubles. The fact that postmodern urban life forms are generally shaped in the axis of the dynamics of the capitalist system. As a result, elements such as competition, individualism, and hedonism become more visible in the cultural field. In this spatial practice, where the social collectivity is replaced by the hedonistic tendencies of the consumption culture, interpersonal communication forms are gradually falling apart [101]. In addition to the aforementioned paralysis of emotions caused by postmodern cultural, social, and economic problems, the COVID-19 pandemic time has appeared as a chaotic example for the present situation. People have begun to struggle with so many things with many new unknown emotions and trauma types that emerged on social media platforms. These unknown terminologies now become a big part of our emotional repertoire. They are multifarious such as thumbnailing, trolling, body shaming, gaslighting, cancel culture or de-platforming, #metoo campaign, toxic masculinity, stress to feed on social media, hashtagging posts, feeling acedia, losing the spatial sense in virtual and augmented reality, being immersed in the metaverse, having been cringed on social media. The list can be endless when it comes to the new phobia types of which may not be classified under the DSM-5 criteria yet to be accepted as legitimate trauma types [102]. Digital habitus is considered as the underlying reason of the problem cause or triggers many new phobias, such as netless phobia, fear of missing out (FOMO), nomophobia, or the feeling of being stalked by unknown gazes due to synoptic surveillance. The dark side of the digital world as we can see here turn many ordinary people’s life into hell. Cyber violence is reinforced by professional criminals who used random pictures of people in deep fake porno. It takes a second to be the victim of deep fake porno. Hence, so-called naïve nudity trend-sending naked pictures to your beloved can be a real trauma for many young people. Similarly, some rather new terminologies, such as crowdsourcing or hive mind activities, can serve just for big data and nobody can guess the real outcome of those digital practices.
It follows that toward a more peaceful and healthy society, we need people who are emotionally healthy as well as mature. For many PTSD patients, time freezes. The past events occasionally haunt them. A similar haunting process can be seen in the Virtual Reality universe. The artistic use of visuals and space in VR technologies can cause new trauma in which time has been expanded as if it is a “duree” experience [103]. Aestheticizing the violence in those arts can trigger fears and worsen the situation. So all these new encounters have brought a new level of violence types in the new media. As it has been presented, each new media and innovation comes with its drawbacks.
Reversing this more positively, media content and AI should collaborate. Psychiatrists, therefore, here must carefully read the signs of digital habitus problems to address the issue by implementing new technologies wisely. One must be aware of the fact that not every innovation has positive effects on society. Reading, interpreting, and using technical tools adopting a critical perspective and without fetishizing things in the digital society will protect individuals from the possible negative effects of these tools.
Prevention of PTSD should start by preventing and monitoring the activities of people on Digital Media. What we need is counter activities to stop the evil deeds and narrations all over the world. A narcissist can disguise himself/herself in social media groups with a hidden agenda camouflaging in amicable chats, can easily take advantage of PTSD people’s vulnerability. They can easily hunt a new dependent person as his/her victim. A cyber sadist invites his/her victim in his digital tower-like Marquis de Sade captured and imprisoned his victims in his tower. Similarly, illegal groups can find their supporters from this digital bowl. Tracking the digital activities of potential criminals, sadists or schizophrenics can save many people’s life. However, all these counter activities are hot topics and controversial as they are against the freedom of communication and privacy. These surveillance and counter-violence discussions are beyond the scope of this study. Pursuing digital technologies to find new ways to reach PTSD can be incomplete if people are not warned against the demonic uses of social media. As explained above, some narcissist people can find their victims via social media platforms. New media here not only digitalize the mindset of people but also offer new facets of crime, violence, and even terrorism. Now cybercrimes, digital violence, data mining, fake accounts, identity stealing, illicit money flows, the resonance of terrorists can cause new traumas in the cyber world. Counter activities to raise awareness of the malicious use of social media is surpassing the job description of social psychiatrists. To fight the root of the problems sometimes can minimize the number of people who would be traumatized in the cyber world. To create a peaceful society, one has a peaceful mindset that is free from restlessness, such as exaggerated startle responses, flashbacks, nightmares, and hypervigilance. Genuine and meaningful communication to lead a meaningful life should not be taken for granted. To provide sensitivity, it is necessary to construct a collective language in the social field by professionals working in the field of communication science and experts in the field of psychology. They should work together to build a new language that prevents social polarization. In addition to the polarized ideologies, digital media have also problematic discourse and contents. Aggressive language in social media is contagious. People who are traumatized, victimized, killed, raped, exiled had not escaped the same pattern of violent discourse. The wild and violent human nature has necessitated certain psychological support systems to cure the victims of tragic events. It is assumed that no society is immune from traumas, and postmodern societies are no exception. Depression, unhappiness, and the symptoms of burnout are highly correlated with the traumatic issues within the scope of postmodern society [91].
As stated above, this study brings Information Age traumas and psychological disorders to the forefront. First trying to find an answer to the questions that why and what types of traumas happen in the Information Age. And, secondly, what changes should be implemented in the discourse and the methodology of the psychiatrists. Trying to answer these questions can provide us a chance not only to define the problem accurately but also to seek valid discourses for the psychiatrists to be used in PTSD cases, particularly in postmodern society. Within the scope of the study, collecting and processing neuroimaging data or utilizing the latest AI techniques can be given as an example of designing new diagnostic and therapeutic methods that rely on neurobiological dimensions. In addition to these new approaches, sociological aspects of PTSD in the digital habitus can be added to develop unique therapy approaches that embrace sociological perspectives of Information Society with a full trajectory of healing practices and a chance of addressing PTSD in its full spectrum.
In conclusion, postmodern city life has worsened the situation of the Information Age regarding PTSD. It affects not only daily life, work-life, education, and academic life, but also affects the total health of society. A person who suffers from PTSD has a lot of issues to cope with. Since the main foci of this study are to explore and exemplify new diagnostic and therapeutic approaches to PTSD cases, a profound analysis of PTSD in terms of its biological, sociological, developmental, psychological, and even ontological aspects are provided by embracing the digital revolutions of the society with its novel implications and insights. To address the issue with its full sides and angles, new treatment opportunities are portrayed as a sine qua non for contemporary psychiatrists.
The authors declare no conflict of interest.
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MRI is commonly used once treating brain, prostate cancers, ankle and foot. The Magnetic Resonance Imaging (MRI) images are usually liable to suffer from noises such as Gaussian noise, salt and pepper noise and speckle noise. So getting of brain image with accuracy is very extremely task. An accurate brain image is very necessary for further diagnosis process. During this chapter, a median filter algorithm will be modified. Gaussian noise and Salt and pepper noise will be added to MRI image. A proposed Median filter (MF), Adaptive Median filter (AMF) and Adaptive Wiener filter (AWF) will be implemented. The filters will be used to remove the additive noises present in the MRI images. The noise density will be added gradually to MRI image to compare performance of the filters evaluation. The performance of these filters will be compared exploitation the applied mathematics parameter Peak Signal-to-Noise Ratio (PSNR).",book:{id:"6144",slug:"high-resolution-neuroimaging-basic-physical-principles-and-clinical-applications",title:"High-Resolution Neuroimaging",fullTitle:"High-Resolution Neuroimaging - Basic Physical Principles and Clinical Applications"},signatures:"Hanafy M. Ali",authors:[{id:"213318",title:"Dr.",name:"Hanafy",middleName:"M.",surname:"Ali",slug:"hanafy-ali",fullName:"Hanafy Ali"}]},{id:"41589",doi:"10.5772/50323",title:"The Role of the Amygdala in Anxiety Disorders",slug:"the-role-of-the-amygdala-in-anxiety-disorders",totalDownloads:9671,totalCrossrefCites:4,totalDimensionsCites:28,abstract:null,book:{id:"2599",slug:"the-amygdala-a-discrete-multitasking-manager",title:"The Amygdala",fullTitle:"The Amygdala - A Discrete Multitasking Manager"},signatures:"Gina L. Forster, Andrew M. Novick, Jamie L. Scholl and Michael J. Watt",authors:[{id:"145620",title:"Dr.",name:"Gina",middleName:null,surname:"Forster",slug:"gina-forster",fullName:"Gina Forster"},{id:"146553",title:"BSc.",name:"Andrew",middleName:null,surname:"Novick",slug:"andrew-novick",fullName:"Andrew Novick"},{id:"146554",title:"MSc.",name:"Jamie",middleName:null,surname:"Scholl",slug:"jamie-scholl",fullName:"Jamie Scholl"},{id:"146555",title:"Dr.",name:"Michael",middleName:null,surname:"Watt",slug:"michael-watt",fullName:"Michael Watt"}]},{id:"26258",doi:"10.5772/28300",title:"Excitotoxicity and Oxidative Stress in Acute Ischemic Stroke",slug:"excitotoxicity-and-oxidative-stress-in-acute-ischemic-stroke",totalDownloads:7157,totalCrossrefCites:6,totalDimensionsCites:25,abstract:null,book:{id:"931",slug:"acute-ischemic-stroke",title:"Acute Ischemic Stroke",fullTitle:"Acute Ischemic Stroke"},signatures:"Ramón Rama Bretón and Julio César García Rodríguez",authors:[{id:"73430",title:"Prof.",name:"Ramon",middleName:null,surname:"Rama",slug:"ramon-rama",fullName:"Ramon Rama"},{id:"124643",title:"Prof.",name:"Julio Cesar",middleName:null,surname:"García",slug:"julio-cesar-garcia",fullName:"Julio Cesar García"}]},{id:"62072",doi:"10.5772/intechopen.78695",title:"Brain-Computer Interface and Motor Imagery Training: The Role of Visual Feedback and Embodiment",slug:"brain-computer-interface-and-motor-imagery-training-the-role-of-visual-feedback-and-embodiment",totalDownloads:1439,totalCrossrefCites:13,totalDimensionsCites:23,abstract:"Controlling a brain-computer interface (BCI) is a difficult task that requires extensive training. Particularly in the case of motor imagery BCIs, users may need several training sessions before they learn how to generate desired brain activity and reach an acceptable performance. A typical training protocol for such BCIs includes execution of a motor imagery task by the user, followed by presentation of an extending bar or a moving object on a computer screen. In this chapter, we discuss the importance of a visual feedback that resembles human actions, the effect of human factors such as confidence and motivation, and the role of embodiment in the learning process of a motor imagery task. Our results from a series of experiments in which users BCI-operated a humanlike android robot confirm that realistic visual feedback can induce a sense of embodiment, which promotes a significant learning of the motor imagery task in a short amount of time. We review the impact of humanlike visual feedback in optimized modulation of brain activity by the BCI users.",book:{id:"6610",slug:"evolving-bci-therapy-engaging-brain-state-dynamics",title:"Evolving BCI Therapy",fullTitle:"Evolving BCI Therapy - Engaging Brain State Dynamics"},signatures:"Maryam Alimardani, Shuichi Nishio and Hiroshi Ishiguro",authors:[{id:"11981",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Ishiguro",slug:"hiroshi-ishiguro",fullName:"Hiroshi Ishiguro"},{id:"231131",title:"Dr.",name:"Maryam",middleName:null,surname:"Alimardani",slug:"maryam-alimardani",fullName:"Maryam Alimardani"},{id:"231134",title:"Dr.",name:"Shuichi",middleName:null,surname:"Nishio",slug:"shuichi-nishio",fullName:"Shuichi Nishio"}]}],mostDownloadedChaptersLast30Days:[{id:"29764",title:"Underlying Causes of Paresthesia",slug:"underlying-causes-of-paresthesia",totalDownloads:192666,totalCrossrefCites:3,totalDimensionsCites:7,abstract:null,book:{id:"1069",slug:"paresthesia",title:"Paresthesia",fullTitle:"Paresthesia"},signatures:"Mahdi Sharif-Alhoseini, Vafa Rahimi-Movaghar and Alexander R. Vaccaro",authors:[{id:"91165",title:"Prof.",name:"Vafa",middleName:null,surname:"Rahimi-Movaghar",slug:"vafa-rahimi-movaghar",fullName:"Vafa Rahimi-Movaghar"}]},{id:"63258",title:"Anatomy and Function of the Hypothalamus",slug:"anatomy-and-function-of-the-hypothalamus",totalDownloads:4558,totalCrossrefCites:6,totalDimensionsCites:12,abstract:"The hypothalamus is a small but important area of the brain formed by various nucleus and nervous fibers. Through its neuronal connections, it is involved in many complex functions of the organism such as vegetative system control, homeostasis of the organism, thermoregulation, and also in adjusting the emotional behavior. The hypothalamus is involved in different daily activities like eating or drinking, in the control of the body’s temperature and energy maintenance, and in the process of memorizing. It also modulates the endocrine system through its connections with the pituitary gland. Precise anatomical description along with a correct characterization of the component structures is essential for understanding its functions.",book:{id:"6331",slug:"hypothalamus-in-health-and-diseases",title:"Hypothalamus in Health and Diseases",fullTitle:"Hypothalamus in Health and Diseases"},signatures:"Miana Gabriela Pop, Carmen Crivii and Iulian Opincariu",authors:null},{id:"57103",title:"GABA and Glutamate: Their Transmitter Role in the CNS and Pancreatic Islets",slug:"gaba-and-glutamate-their-transmitter-role-in-the-cns-and-pancreatic-islets",totalDownloads:3478,totalCrossrefCites:3,totalDimensionsCites:9,abstract:"Glutamate and gamma-aminobutyric acid (GABA) are the major neurotransmitters in the mammalian brain. Inhibitory GABA and excitatory glutamate work together to control many processes, including the brain’s overall level of excitation. The contributions of GABA and glutamate in extra-neuronal signaling are by far less widely recognized. In this chapter, we first discuss the role of both neurotransmitters during development, emphasizing the importance of the shift from excitatory to inhibitory GABAergic neurotransmission. The second part summarizes the biosynthesis and role of GABA and glutamate in neurotransmission in the mature brain, and major neurological disorders associated with glutamate and GABA receptors and GABA release mechanisms. The final part focuses on extra-neuronal glutamatergic and GABAergic signaling in pancreatic islets of Langerhans, and possible associations with type 1 diabetes mellitus.",book:{id:"6237",slug:"gaba-and-glutamate-new-developments-in-neurotransmission-research",title:"GABA And Glutamate",fullTitle:"GABA And Glutamate - New Developments In Neurotransmission Research"},signatures:"Christiane S. Hampe, Hiroshi Mitoma and Mario Manto",authors:[{id:"210220",title:"Prof.",name:"Christiane",middleName:null,surname:"Hampe",slug:"christiane-hampe",fullName:"Christiane Hampe"},{id:"210485",title:"Prof.",name:"Mario",middleName:null,surname:"Manto",slug:"mario-manto",fullName:"Mario Manto"},{id:"210486",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Mitoma",slug:"hiroshi-mitoma",fullName:"Hiroshi Mitoma"}]},{id:"35802",title:"Cross-Cultural/Linguistic Differences in the Prevalence of Developmental Dyslexia and the Hypothesis of Granularity and Transparency",slug:"cross-cultural-linguistic-differences-in-the-prevalence-of-developmental-dyslexia-and-the-hypothesis",totalDownloads:3601,totalCrossrefCites:2,totalDimensionsCites:7,abstract:null,book:{id:"673",slug:"dyslexia-a-comprehensive-and-international-approach",title:"Dyslexia",fullTitle:"Dyslexia - A Comprehensive and International Approach"},signatures:"Taeko N. Wydell",authors:[{id:"87489",title:"Prof.",name:"Taeko",middleName:"N.",surname:"Wydell",slug:"taeko-wydell",fullName:"Taeko Wydell"}]},{id:"58597",title:"Testosterone and Erectile Function: A Review of Evidence from Basic Research",slug:"testosterone-and-erectile-function-a-review-of-evidence-from-basic-research",totalDownloads:1331,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Androgens are essential for male physical activity and normal erectile function. Hence, age-related testosterone deficiency, known as late-onset hypogonadism (LOH), is considered a risk factor for erectile dysfunction (ED). This chapter summarizes relevant basic research reports examining the effects of testosterone on erectile function. Testosterone affects several organs and is especially active on the erectile tissue. The mechanism of testosterone deficiency effects on erectile function and the results of testosterone replacement therapy (TRT) have been well studied. Testosterone affects nitric oxide (NO) production and phosphodiesterase type 5 (PDE-5) expression in the corpus cavernosum through molecular pathways, preserves smooth muscle contractility by regulating both contraction and relaxation, and maintains the structure of the corpus cavernosum. Interestingly, testosterone deficiency has relationship to neurological diseases, which leads to ED. Testosterone replacement therapy is widely used to treat patients with testosterone deficiency; however, this treatment might also induce some problems. Basic research suggests that PDE-5 inhibitors, L-citrulline, and/or resveratrol therapy might be effective therapeutic options for testosterone deficiency-induced ED. Future research should confirm these findings through more specific experiments using molecular tools and may shed more light on endocrine-related ED and its possible treatments.",book:{id:"5994",slug:"sex-hormones-in-neurodegenerative-processes-and-diseases",title:"Sex Hormones in Neurodegenerative Processes and Diseases",fullTitle:"Sex Hormones in Neurodegenerative Processes and Diseases"},signatures:"Tomoya Kataoka and Kazunori Kimura",authors:[{id:"219042",title:"Ph.D.",name:"Tomoya",middleName:null,surname:"Kataoka",slug:"tomoya-kataoka",fullName:"Tomoya Kataoka"},{id:"229066",title:"Prof.",name:"Kazunori",middleName:null,surname:"Kimura",slug:"kazunori-kimura",fullName:"Kazunori Kimura"}]}],onlineFirstChaptersFilter:{topicId:"18",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81646",title:"Cortical Plasticity under Ketamine: From Synapse to Map",slug:"cortical-plasticity-under-ketamine-from-synapse-to-map",totalDownloads:14,totalDimensionsCites:0,doi:"10.5772/intechopen.104787",abstract:"Sensory systems need to process signals in a highly dynamic way to efficiently respond to variations in the animal’s environment. For instance, several studies showed that the visual system is subject to neuroplasticity since the neurons’ firing changes according to stimulus properties. This dynamic information processing might be supported by a network reorganization. Since antidepressants influence neurotransmission, they can be used to explore synaptic plasticity sustaining cortical map reorganization. To this goal, we investigated in the primary visual cortex (V1 of mouse and cat), the impact of ketamine on neuroplasticity through changes in neuronal orientation selectivity and the functional connectivity between V1 cells, using cross correlation analyses. We found that ketamine affects cortical orientation selectivity and alters the functional connectivity within an assembly. These data clearly highlight the role of the antidepressant drugs in inducing or modeling short-term plasticity in V1 which suggests that cortical processing is optimized and adapted to the properties of the stimulus.",book:{id:"11374",title:"Sensory Nervous System - Computational Neuroimaging Investigations of Topographical Organization in Human Sensory Cortex",coverURL:"https://cdn.intechopen.com/books/images_new/11374.jpg"},signatures:"Ouelhazi Afef, Rudy Lussiez and Molotchnikoff Stephane"},{id:"81582",title:"The Role of Cognitive Reserve in Executive Functioning and Its Relationship to Cognitive Decline and Dementia",slug:"the-role-of-cognitive-reserve-in-executive-functioning-and-its-relationship-to-cognitive-decline-and",totalDownloads:22,totalDimensionsCites:0,doi:"10.5772/intechopen.104646",abstract:"In this chapter, we explore how cognitive reserve is implicated in coping with the negative consequences of brain pathology and age-related cognitive decline. Individual differences in cognitive performance are based on different brain mechanisms (neural reserve and neural compensation), and reflect, among others, the effect of education, occupational attainment, leisure activities, and social involvement. These cognitive reserve proxies have been extensively associated with efficient executive functioning. We discuss and focus particularly on the compensation mechanisms related to the frontal lobe and its protective role, in maintaining cognitive performance in old age or even mitigating the clinical expression of dementia.",book:{id:"11742",title:"Neurophysiology",coverURL:"https://cdn.intechopen.com/books/images_new/11742.jpg"},signatures:"Gabriela Álvares-Pereira, Carolina Maruta and Maria Vânia Silva-Nunes"},{id:"81488",title:"Aggression and Sexual Behavior: Overlapping or Distinct Roles of 5-HT1A and 5-HT1B Receptors",slug:"aggression-and-sexual-behavior-overlapping-or-distinct-roles-of-5-ht1a-and-5-ht1b-receptors",totalDownloads:19,totalDimensionsCites:0,doi:"10.5772/intechopen.104872",abstract:"Distinct brain mechanisms for male aggressive and sexual behavior are present in mammalian species, including man. However, recent evidence suggests a strong connection and even overlap in the central nervous system (CNS) circuitry involved in aggressive and sexual behavior. The serotonergic system in the CNS is strongly involved in male aggressive and sexual behavior. In particular, 5-HT1A and 5-HT1B receptors seem to play a critical role in the modulation of these behaviors. The present chapter focuses on the effects of 5-HT1A- and 5-HT1B-receptor ligands in male rodent aggression and sexual behavior. Results indicate that 5-HT1B-heteroreceptors play a critical role in the modulation of male offensive behavior, although a definite role of 5-HT1A-auto- or heteroreceptors cannot be ruled out. 5-HT1A receptors are clearly involved in male sexual behavior, although it has to be yet unraveled whether 5-HT1A-auto- or heteroreceptors are important. Although several key nodes in the complex circuitry of aggression and sexual behavior are known, in particular in the medial hypothalamus, a clear link or connection to these critical structures and the serotonergic key receptors is yet to be determined. This information is urgently needed to detect and develop new selective anti-aggressive (serenic) and pro-sexual drugs for human applications.",book:{id:"10195",title:"Serotonin and the CNS - New Developments in Pharmacology and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg"},signatures:"Berend Olivier and Jocelien D.A. Olivier"},{id:"81093",title:"Prehospital and Emergency Room Airway Management in Traumatic Brain Injury",slug:"prehospital-and-emergency-room-airway-management-in-traumatic-brain-injury",totalDownloads:49,totalDimensionsCites:0,doi:"10.5772/intechopen.104173",abstract:"Airway management in trauma is critical and may impact patient outcomes. Particularly in traumatic brain injury (TBI), depressed level of consciousness may be associated with compromised protective airway reflexes or apnea, which can increase the risk of aspiration or result in hypoxemia and worsen the secondary brain damage. Therefore, patients with TBI and Glasgow Coma Scale (GCS) ≤ 8 have been traditionally managed by prehospital or emergency room (ER) endotracheal intubation. However, recent evidence challenged this practice and even suggested that routine intubation may be harmful. This chapter will address the indications and optimal method of securing the airway, prehospital and in the ER, in patients with traumatic brain injury.",book:{id:"11367",title:"Traumatic Brain Injury",coverURL:"https://cdn.intechopen.com/books/images_new/11367.jpg"},signatures:"Dominik A. Jakob, Jean-Cyrille Pitteloud and Demetrios Demetriades"},{id:"81011",title:"Amino Acids as Neurotransmitters. The Balance between Excitation and Inhibition as a Background for Future Clinical Applications",slug:"amino-acids-as-neurotransmitters-the-balance-between-excitation-and-inhibition-as-a-background-for-f",totalDownloads:19,totalDimensionsCites:0,doi:"10.5772/intechopen.103760",abstract:"For more than 30 years, amino acids have been well-known (and essential) participants in neurotransmission. They act as both neuromediators and metabolites in nervous tissue. Glycine and glutamic acid (glutamate) are prominent examples. These amino acids are agonists of inhibitory and excitatory membrane receptors, respectively. Moreover, they play essential roles in metabolic pathways and energy transformation in neurons and astrocytes. Despite their obvious effects on the brain, their potential role in therapeutic methods remains uncertain in clinical practice. In the current chapter, a comparison of the crosstalk between these two systems, which are responsible for excitation and inhibition in neurons, is presented. The interactions are discussed at the metabolic, receptor, and transport levels. Reaction-diffusion and a convectional flow into the interstitial fluid create a balanced distribution of glycine and glutamate. Indeed, the neurons’ final physiological state is a result of a balance between the excitatory and inhibitory influences. However, changes to the glycine and/or glutamate pools under pathological conditions can alter the state of nervous tissue. Thus, new therapies for various diseases may be developed on the basis of amino acid medication.",book:{id:"10890",title:"Recent Advances in Neurochemistry",coverURL:"https://cdn.intechopen.com/books/images_new/10890.jpg"},signatures:"Yaroslav R. Nartsissov"},{id:"80821",title:"Neuroimmunology and Neurological Manifestations of COVID-19",slug:"neuroimmunology-and-neurological-manifestations-of-covid-19",totalDownloads:41,totalDimensionsCites:0,doi:"10.5772/intechopen.103026",abstract:"Infection with SARS-CoV-2 is causing coronavirus disease in 2019 (COVID-19). Besides respiratory symptoms due to an attack on the broncho-alveolar system, COVID-19, among others, can be accompanied by neurological symptoms because of the affection of the nervous system. These can be caused by intrusion by SARS-CoV-2 of the central nervous system (CNS) and peripheral nervous system (PNS) and direct infection of local cells. In addition, neurological deterioration mediated by molecular mimicry to virus antigens or bystander activation in the context of immunological anti-virus defense can lead to tissue damage in the CNS and PNS. In addition, cytokine storm caused by SARS-CoV-2 infection in COVID-19 can lead to nervous system related symptoms. Endotheliitis of CNS vessels can lead to vessel occlusion and stroke. COVID-19 can also result in cerebral hemorrhage and sinus thrombosis possibly related to changes in clotting behavior. Vaccination is most important to prevent COVID-19 in the nervous system. There are symptomatic or/and curative therapeutic approaches to combat COVID-19 related nervous system damage that are partly still under study.",book:{id:"10890",title:"Recent Advances in Neurochemistry",coverURL:"https://cdn.intechopen.com/books/images_new/10890.jpg"},signatures:"Robert Weissert"}],onlineFirstChaptersTotal:17},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:288,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"13",title:"Veterinary Medicine and Science",doi:"10.5772/intechopen.73681",issn:"2632-0517",scope:"Paralleling similar advances in the medical field, astounding advances occurred in Veterinary Medicine and Science in recent decades. These advances have helped foster better support for animal health, more humane animal production, and a better understanding of the physiology of endangered species to improve the assisted reproductive technologies or the pathogenesis of certain diseases, where animals can be used as models for human diseases (like cancer, degenerative diseases or fertility), and even as a guarantee of public health. Bridging Human, Animal, and Environmental health, the holistic and integrative “One Health” concept intimately associates the developments within those fields, projecting its advancements into practice. This book series aims to tackle various animal-related medicine and sciences fields, providing thematic volumes consisting of high-quality significant research directed to researchers and postgraduates. It aims to give us a glimpse into the new accomplishments in the Veterinary Medicine and Science field. By addressing hot topics in veterinary sciences, we aim to gather authoritative texts within each issue of this series, providing in-depth overviews and analysis for graduates, academics, and practitioners and foreseeing a deeper understanding of the subject. Forthcoming texts, written and edited by experienced researchers from both industry and academia, will also discuss scientific challenges faced today in Veterinary Medicine and Science. In brief, we hope that books in this series will provide accessible references for those interested or working in this field and encourage learning in a range of different topics.",coverUrl:"https://cdn.intechopen.com/series/covers/13.jpg",latestPublicationDate:"May 18th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:10,editor:{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:5,paginationItems:[{id:"19",title:"Animal Science",coverUrl:"https://cdn.intechopen.com/series_topics/covers/19.jpg",editor:{id:"259298",title:"Dr.",name:"Edward",middleName:null,surname:"Narayan",slug:"edward-narayan",fullName:"Edward Narayan",profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",biography:"Dr. Edward Narayan graduated with Ph.D. degree in Biology from the University of the South Pacific and pioneered non-invasive reproductive and stress endocrinology tools for amphibians - the novel development and validation of non-invasive enzyme immunoassays for the evaluation of reproductive hormonal cycle and stress hormone responses to environmental stressors. \nDr. Narayan leads the Stress Lab (Comparative Physiology and Endocrinology) at the University of Queensland. 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Science",value:19,count:5}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:3},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:1},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:148,paginationItems:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/165328/images/system/165328.jpg",biography:"Vahid Asadpour, MS, Ph.D., is currently with the Department of Research and Evaluation, Kaiser Permanente Southern California. He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:null},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"357085",title:"Mr.",name:"P. Mohan",middleName:null,surname:"Anand",slug:"p.-mohan-anand",fullName:"P. Mohan Anand",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356696",title:"Ph.D. Student",name:"P.V.",middleName:null,surname:"Sai Charan",slug:"p.v.-sai-charan",fullName:"P.V. Sai Charan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"357086",title:"Prof.",name:"Sandeep K.",middleName:null,surname:"Shukla",slug:"sandeep-k.-shukla",fullName:"Sandeep K. Shukla",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356823",title:"MSc.",name:"Seonghee",middleName:null,surname:"Min",slug:"seonghee-min",fullName:"Seonghee Min",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Daegu University",country:{name:"Korea, South"}}},{id:"353307",title:"Prof.",name:"Yoosoo",middleName:null,surname:"Oh",slug:"yoosoo-oh",fullName:"Yoosoo Oh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:"Yoosoo Oh received his Bachelor's degree in the Department of Electronics and Engineering from Kyungpook National University in 2002. He obtained his Master’s degree in the Department of Information and Communications from Gwangju Institute of Science and Technology (GIST) in 2003. In 2010, he received his Ph.D. degree in the School of Information and Mechatronics from GIST. In the meantime, he was an executed team leader at Culture Technology Institute, GIST, 2010-2012. In 2011, he worked at Lancaster University, the UK as a visiting scholar. In September 2012, he joined Daegu University, where he is currently an associate professor in the School of ICT Conver, Daegu University. Also, he served as the Board of Directors of KSIIS since 2019, and HCI Korea since 2016. From 2017~2019, he worked as a center director of the Mixed Reality Convergence Research Center at Daegu University. From 2015-2017, He worked as a director in the Enterprise Supporting Office of LINC Project Group, Daegu University. His research interests include Activity Fusion & Reasoning, Machine Learning, Context-aware Middleware, Human-Computer Interaction, etc.",institutionString:null,institution:{name:"Daegu Gyeongbuk Institute of Science and Technology",country:{name:"Korea, South"}}},{id:"262719",title:"Dr.",name:"Esma",middleName:null,surname:"Ergüner Özkoç",slug:"esma-erguner-ozkoc",fullName:"Esma Ergüner Özkoç",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Başkent University",country:{name:"Turkey"}}},{id:"346530",title:"Dr.",name:"Ibrahim",middleName:null,surname:"Kaya",slug:"ibrahim-kaya",fullName:"Ibrahim Kaya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"419199",title:"Dr.",name:"Qun",middleName:null,surname:"Yang",slug:"qun-yang",fullName:"Qun Yang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Auckland",country:{name:"New Zealand"}}},{id:"351158",title:"Prof.",name:"David W.",middleName:null,surname:"Anderson",slug:"david-w.-anderson",fullName:"David W. 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