\r\n\tThe primary objective of this book is to provide the specialists involved in the clinical management and experimental research of acute and chronic leukemias updates on the theoretical aspects as well as state-of-the-art diagnostic and clinical management of acute and chronic leukemias.
\r\n
\r\n\tThe book is intended to cover a broad spectrum of leukemia-related topics such as: \r\n\t-novel and still evolving insights into the biology and diagnosis and how these result in new drug approvals and new therapeutic options with a focus on molecular and immunotherapeutic targeted therapeutics, \r\n\t- the molecular and functional features of leukemic stem cells and their interaction with the microenvironment, \r\n\t- preleukemic hematopoiesis and clonal diversity, \r\n\t- new standard treatment algorithms, \r\n\t- mechanisms of resistance and disease progression \r\n\t- diagnosis and management of rare acute leukemia subtypes, \r\n\t- Covid-19 aspects in specific leukemia categories, \r\n\t- real-world data \r\n\t- new drugs in development
",isbn:"978-1-80356-906-2",printIsbn:"978-1-80356-905-5",pdfIsbn:"978-1-80356-907-9",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"30b431385424f0b84aee499d839f46cc",bookSignature:"Prof. Margarita Guenova and Prof. Gueorgui Balatzenko",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11599.jpg",keywords:"Leukemogenesis, Diagnosis, Target Therapies, Minimal Residual Disease, COVID-19, Molecular Biology, Mechanisms of Resistance and Disease Progression, Treatment-Free Remission, New Drugs in Development, Acute Lymphoblastic Leukemia, Chronic Lymphocytic Leukemia, Acute Myeloid Leukemia, Biomarkers",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 5th 2022",dateEndSecondStepPublish:"June 15th 2022",dateEndThirdStepPublish:"August 14th 2022",dateEndFourthStepPublish:"November 2nd 2022",dateEndFifthStepPublish:"January 1st 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"20 days",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Head of the national reference diagnostic laboratory for malignant blood diseases, professor of hematology, member of national and international medical societies, and author/co-author of research papers related to leukemia.",coeditorOneBiosketch:"Dr.Balatzenko is a Professor of Hematology and Blood Transfusion at the Laboratory of Cytogenetics and Molecular Biology at the National Specialised Hospital for Active Treatment of Haematological Diseases, Sofia, Bulgaria. He has authored and co-authored many articles in peer-reviewed journals and book chapters. He is a member of several professional societies, such as the Bulgarian Society of Hematology, the Bulgarian Society of Genetics, and the European Hematology Association; a life member of the UICC.",coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"52938",title:"Prof.",name:"Margarita",middleName:null,surname:"Guenova",slug:"margarita-guenova",fullName:"Margarita Guenova",profilePictureURL:"https://mts.intechopen.com/storage/users/52938/images/system/52938.jpg",biography:"Professor Dr. Margarita Guenova received her medical training at the Medical University of Sofia and her PhD degree at the National Center of Haematology in 2000. She is employed as Head of the Laboratory of Haematopathology and Immunology and Professor of Hematology and Blood Transfusion at the National Specialised Hospital for Active Treatment of Haematological Diseases, Sofia, Bulgaria, teaching both undergraduate and graduate studies at the Sofia Medical University. She specializes in the field of leukemia and lymphoma diagnostics. In regard to her scientific interests, she worked on the elucidation of critical mechanisms of leukemia pathogenesis and progression, investigation of clinically relevant biomarkers and potential targets for therapy in leukemias and lymphomas, characterization of leukemic stem cell populations, minimal residual disease, and implementation of a multifaceted approach in oncohematology. Dr. Guenova has authored and coauthored many abstracts, articles in peer-reviewed journals, and book chapters. She serves on several editorial boards and is the Past-president of the Bulgarian Society of Hematology as well as a member of several professional societies, such as the Bulgarian Society of Pathology, the Bulgarian Association of Clinical Immunology, the European Hematology Association, the European Association of Haematopathology, and the International Society of Haematology.",institutionString:"Laboratory of Haematopathology and Immunology, National Specialized Hospital for Active Treatment of Haematological Diseases",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"3",institution:null}],coeditorOne:{id:"56314",title:"Prof.",name:"Gueorgui",middleName:null,surname:"Balatzenko",slug:"gueorgui-balatzenko",fullName:"Gueorgui Balatzenko",profilePictureURL:"https://mts.intechopen.com/storage/users/56314/images/5371_n.jpg",biography:"Professor Dr. Gueorgui Balatzenko received his medical training at the Medical University of Sofia and his PhD degree at the National Center of Haematology in 2002. He obtained additional qualifications at the Red Cross Blood Bank, Groningen-Drenthe, the Netherlands; Institute Paoli-Calmettes, Marseille, France; and Necker-Enfants Malades, Paris, France. He is Professor of Hematology and Blood Transfusion at the Laboratory of Cytogenetics and Molecular Biology at the National Specialised Hospital for Active Treatment of Haematological Diseases, Sofia, Bulgaria, teaching both undergraduate and graduate studies at the Sofia Medical University. His major interest is in the field of molecular investigations in leukemias. In regard to his scientific achievements, he worked on the elucidation of \nthe incidence and clinical relevance of molecular biomarkers in chronic and acute leukemias as well as on the molecular monitoring of treatment response. Dr. Balatzenko has authored and coauthored many articles in peer-reviewed journals and book chapters. He is a member of several professional societies, such as the Bulgarian Society of Hematology, the Bulgarian Society of Genetics, and the European Hematology Association; a life member of the UICC; and a referee for international journals.",institutionString:"Laboratory of Cytogenetics and Molecular Biology at the National Specialised Hospital for Active Treatment of Haematological Diseases",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"440204",firstName:"Ana",lastName:"Cink",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/440204/images/20006_n.jpg",email:"ana.c@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. 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\n
1. Introduction
\n
In communication systems waveforms enable the allocation of data on the joint time-frequency (TF) domain by transmitting and receiving proper signals. As the waveform design deals with the methods to generate transmitted signals at the transmitter, and receive at receiver side through a channel, the design criteria depend on demands of users, channel conditions, system, and technology criteria. Therefore, the design criteria change with respect to the advancement of technologies. The waveform techniques in 2G/3G/4G mobile technologies cannot meet the demands of next‐generation wireless networks. To overcome problems stemming from the new demands, either it is required to design new waveform techniques, or propose improved versions of the waveform used in 4G, i.e., the orthogonal frequency division multiplexing (OFDM) [1, 2] at least.
\n
The answer to the question “Why do we need new waveforms?” reveals important issues. The state‐of‐the‐art radio access technology is summarized in Figure 1. Accordingly, the ambitious performance goals for 5G networks are 10–100 times higher typical user data rates, 10–100 times more connected devices, 10 times lower network energy consumption, less than 1 ms end‐to‐end latency, and 10000 times higher mobile data traffic per geographical area [1, 3]. The 5G communication systems that are expected to have a heterogeneous network structure are planned to design in such a way that they provide service not only for people as real users but also for various kinds of equipment. While designing the system in this way, we should keep in mind that, features for each user, such as transmission packet lengths, data rates, data transmission frequencies, and capacities would be different. These various requests of users, lead to lots of issues, such as synchronization in time and frequency. To overcome these problems, it is required to design new techniques capable of utilizing the spectrum more efficiently, with higher data rates, with lower energy consumption, and latency [4, 5].
\n
Figure 1.
The state‐of‐the‐art radio access technology: moving from voice to 5G.
\n
An ideal waveform shall fulfill the following requirements (i) low power consumption, (ii) high data rates, (iii) spectrum efficient, (iv) low latency, (v) easy to implement, and (vi) low out‐of‐band emission. Additionally, a well‐designed waveform must be robust to disruptive features of communication channels, and be able to easily extract these effects at the receiver side. It must be compliant with massive multiple‐input multiple‐output (MIMO) systems, and adaptive for users with different access requirements on heterogeneous networks. Absolutely, it is not possible to find a waveform that supplies to all requirements perfectly. However, the accurate waveform design procedure meets most of these features at optimum ways.
\n
OFDM is the dominant technology for today\'s broadband multicarrier communications. However, it is considered as an undesirable solution for 5G wireless networks due to its shortcomings on some channel effects [6]. The other shortcomings are the out-of-band (OOB) emission [7] and peak‐to‐average power ratio (PAPR) problems [8]. Rectangular pulse shaping of OFDM introduces the nonnegligible out‐of‐band emissions, which cause interferences among adjacent bands, whereas usage of independent phases for subcarriers causes PAPR problem.
\n
In literature, up to now several candidate waveforms are proposed to achieve 5G communication system requirements. The multicarrier waveforms based on filtering operations are good candidate waveforms to overcome OOB emission problems. Filter bank‐based multicarrier (FBMC) and its varieties, generalized frequency division multiplexing (GFDM), and universal filtered multicarrier (UFMC) are among these candidate waveforms.
\n
FBMC is one of the multicarrier waveforms using filtering operation. Filtered multitone (FMT), staggered multitone (SMT), and cosine‐modulated multitone (CMT) modulations are variants of the FBMC transmission scheme [9]. The main differences of these schemes are their TF domain allocations. Contrary to FMT, the subcarriers of SMT and CMT are overlapping. So, FMT is not spectrally efficient.
\n
GFDM can be considered as a type of filter bank-based multicarrier modulation scheme with transmission filters that are shifted in time and frequency domains. The novelty of GFDM is in its flexibility, which can address the different applications. On the other hand, most of the real‐time applications (i.e., tactile Internet) need lower latency. Low latency can be obtained with small symbol durations and less complex transceiver structures. It is possible to reduce signal durations for GFDM by designing appropriate TF structures [10]. The complexity that is caused by filtering operations can be reduced by using polyphase structures of filters [11]. OOB emission can be reduced via these using filters that have low side lobe levels at their frequency responses.
\n
UFMC is another waveform with low OOB emission [12, 13]. The distinguishing feature of UFMC is in filtering the group of subcarriers instead of filtering each subcarrier. The filters used for UFMC have large bandwidth and short impulse response. It makes short burst transmission. This scheme is not suitable for applications that need time synchronization.
\n
The purpose of this chapter is to present the basics of waveform design for 5G networks. To achieve this, the rest of the chapter is organized as follows. In Section 2, the fundamentals of waveform design that includes TF lattice structures and pulse shaping are explained. In Section 3, the concept of multicarrier waveforms and transceiver structures such as OFDM, FBMC, and FMT with nonuniformly divided bandwidth allocations and GFDM are discussed. In Section 4, the performance comparisons of the waveforms are evaluated. Conclusion and future directions remarks are given in Section 5.
\n
\n
\n
2. Fundamentals of waveform design
\n
Forming TF lattice structures and pulse shaping are the essential steps for waveform design. Time and frequency allocation of transmitted and also received signals are performed through TF lattice structures. The pulse shaping is also an important step to avoid interferences among the symbols in both time and frequency domains.
\n
\n
2.1. TF lattice structures
\n
TF lattice structures contain information about the relationship between time and frequency support information for all symbols. TF lattice structures depend on transmission schemes, i.e., single‐carrier, multicarrier, time‐division, and frequency‐division transmission schemes.
\n
Figure 2 shows the TF lattice structures of time and frequency division multiplexing (TDMA and FDMA, respectively). If frequency spectrum is divided into subbands, the waveform is called multicarrier waveform. Each carrier in a subband is called a subcarrier. Each grid in TF lattice structure indicates a subsymbol. The symbols are transmitted at every T seconds.
\n
Figure 2.
Frequency division and time division multiplexing as a TF lattice structure.
\n
Data rate depends on the transmission bandwidth, channel capacity, signal‐to‐noise ratio (SNR), and the receiver capacity. Data rate is related to the frequency resolution that is expressed by\n
Δf=1T=fsNE1
\n
where fs is the sampling frequency and Δf is the difference between two adjacent frequency bins. In order to resolve frequencies, it needs to make Δf sufficiently small and that is referred to as increasing the frequency resolution.
\n
A signal s(t) can be represented in the frequency domain by its Fourier transform S(f) as\n
S(f)=ℱ{s(t)}=∫−∞∞s(t)e−j2πftdt.E2
\n
Time‐domain signal s(t) has a finite duration. Finite time duration implies infinite bandwidth. On the contrary, finite bandwidth implies infinite time duration. In practice, time duration and bandwidth are limited. A time‐limited signal sT(t) can be expressed by multiplying a rectangular pulse of duration T as\n
sT(t)=s(t) rec (t/T).E3
\n
The Fourier transform of the time‐limited signal in Eq. (3) is\n
ST(f)=S(f)*Tsinc(fT)E4
\n
where * is the convolution operation in the frequency domain. Because of the convolution operation, bandwidth of ST(f) becomes unlimited.The time and frequency domain representations of the rectangular pulse are given in Figure 3. Time domain is limited, but frequency response spreads over a large range of bandwidth.
\n
Figure 3.
(a) The impulse response and (b) frequency response of a rectangular pulse: The impulse response is limited; frequency response spreads over the frequency domain and includes high‐level side lobes.
\n
Such infinite bandwidth information is not realistic. For that reason, a bandwidth that contains most of the signal energy can be used. The extreme frequencies (fmin,fmax) can be defined from the desired signal energies, and the bandwidth is B=fmax−fmin.
\n
Time‐bandwidth product is a design parameter of TF lattice structure. Time‐bandwidth product is expressed by B×T that measures localization in time and frequency domain. The aim is to minimize the unit area of TF lattice structures. But there is a lower limit that is obtained from the uncertainty principle [14, 15]. The time domain representation of a Gaussian pulse is\n
s(t)=e−∝2t2E5
\n
with time duration T=1/2∝ and bandwidth B=∝/2π. The time‐bandwidth product of Gaussian pulse becomes\n
B×T=14π.E6
\n
Time‐bandwidth product of Gaussian pulses in Eq. (6) is the lower limit. For all other signals, time‐bandwidth product is limited below B×T>14π based on the celebrated uncertainty principle.
\n
The TF lattice structures of several waveforms are shown in Figure 4. These structures give information about the rules of frequency division and time division of waveforms. TF lattice structure of OFDM is shown in Figure 4(a) for a transmission bandwidth, B. The transmission bandwidth is divided into N subbands through IFFT operations. On the other hand, according to the TF lattice structure of GFDM, the time domain is also divided into time slots.
\n
Figure 4.
(a) OFDM, (b) single carrier‐FDE, and (c) GFDM.
\n
The transmitted signal with proper time and frequency shifts can be expressed as\n
x(n)=∑m=0M−1∑k=0K−1sk,mgm(n)e−j2πnkKE7
\n
where sk,m is the data symbol with a subcarrier subscript k and subsymbol subscript m where k=0,1,…,K−1 and m=0,1,…,M−1, respectively. gm(n) is a time‐shifted version of a prototype filter g(n). In OFDM, prototype filter g(n) is replaced with 1 and each subcarrier contains one subsymbol, which means M=1. Thus, the OFDM symbol is simply\n
x(n)=∑k=0K−1sk,me−j2πnkK.E8
\n
In the same approach, single carrier transmission is obtained by replacing K=1 and g(n) with Dirichlet pulse [16]. The symbols are transmitted by dividing into time slots and each subsymbol contains all frequency components of the transmission bandwidth.
\n
TF lattice structures of GFDM waveform are the combination of the frequency‐division and time‐division based waveforms that are defined in Eq. (7). The transmitted signal is obtained by convolution of data with filter gm(n) that is the time‐ shifted and frequency‐shifted version of prototype filter g(n). The projection of filters gm(n) on time‐frequency domain is not rectangular as indicated in Figure 3.
\n
Toroidal lattice [17] and hexagonal lattice [18] are other lattice structures proposed in the literature. Hermite‐Gaussian functions are well‐localized in both time and frequency domains and the time‐bandwidth product of its zeroth‐order function equals to the lowest time‐bandwidth product, i.e., 1/4π. The time‐ and frequency‐domain representation of the third‐order Hermite‐Gaussian pulse and a toroidal rectangular TF lattice structure are given in Figure 5.
\n
Figure 5.
Toroidal lattice structure. (a) Third order of Hermite pulse and (b) rectangular lattice with Hermite pulses [17].
\n
Toroidal rectangular lattice structure provides more data rate as indicated in [17]. On the other hand, the hexagonal lattice structure is more robust for inferences and channel effects [18, 19].
\n
Briefly, the symbol durations and bandwidths are important parameters of TF lattice structures. These parameters are chosen according to the requirements of the users and channel conditions. The details are given in Section 4. The next step of the waveform design is pulse shaping. The pulse shaping is the determination of time and frequency limits of a pulse to fill in each grid in the TF lattice. The methods and constraints of pulse shaping are given in the following section.
\n
\n
\n
2.2. Pulse shaping
\n
In a communication system, pulse shaping is important to generate band‐ and time‐limited transmitted signal. Limiting the signals of symbols in time and frequency domains is important to avoid interferences.
\n
The definition of pulse shaping is the filtering process that maps modulated signals to the TF lattice to control the interferences. The main problem of pulse shaping is the reciprocal relation between time and frequency domains. It means that a narrow pulse in the time domain has wider spectrum in the frequency domain. If the width of a pulse is increased in the time domain, the width of the spectrum in the frequency domain will be decreased. Of course, the pulse cannot be widened to infinity as in the ideal case. This causes out‐of‐band emission in the frequency domain. Well‐designed filters according to design requirements can prevent or at least decrease out‐of‐band emission and also interference.
\n\n
Figure 6.
Raised‐cosine filter: (a) time and (b) frequency responses with various roll‐off factors. If roll‐off factor is β=0, the impulse response is similar to the rectangular pulse.
\n\n
The Fourier transform of the rectangular pulse is a sinc function that has very large bandwidth because of the side lobes. The problems of reducing the level of side lobes and the signal power out of the transmitted band can be solved by windowing. The windowing operation limits the out‐of‐band energy by smoothing the time‐domain function. So, in order to mask to spectrum, pulse shaping, i.e., time‐domain windowing is used. Raised cosine filter and Gaussian filter are the famous pulse shaping filters. The impulse response of these filters are given by\n
hRC(t)=sin(πt/T)πt/Tcos(πβt/T)1−4β2t2/T2E9
\n
and\n
hGaussian(t)=2πIn2(BT)e−2π2In2(BT)2t2E10
\n
respectively. Here β is called the roll‐off factor that is in the range of 0≤β≤1. The frequency responses are\n
The time and frequency responses of the raised‐cosine filter for different β values are given in Figure 6. The roll‐off factor β is the measure of the excess bandwidth of the filter. If β=0, the impulse response approaches to sinc(t/T) function and the frequency response approaches to rect(fT) rectangular function.
\n
The famous windowing functions and their time‐domain sequences are given in Table 1.
\n\n
\n
\n
\n
Window
\n
Time domain sequence h(n) for 0 ≤ n ≤ L – 1 length of filter
\n
\n
\n
1
\n
Blackman
\n
0.42−0.5cos2πnL−1+0.08cos4πnL−1
\n
\n
\n
2
\n
Hamming
\n
0.54−0.46cos2πnL−1
\n
\n
\n
3
\n
Hanning
\n
12(1−cos2πnL−1)
\n
\n
\n
4
\n
Kaiser
\n
I0[α(L−12)2−(n−L−12)2]I0[α(L−12)]
\n
\n
\n
\n
I0: zeroth‐order Bessel, α: positive real number
\n
\n\n
Table 1.
Common window functions.
\n
\n
\n
\n
3. Transceiver schemes for 5G wireless networks
\n
Multicarrier transmission is the best way to fix the problems due to frequency‐selective channel conditions. Contrary to the single‐carrier modulation techniques, that use only one carrier at all times, multicarrier modulation divides the band into more subcarriers. The ideal equalizer has a frequency response that is the inverse of the frequency response of the channel. So, the equalization of multicarrier transmission is easier for the frequency‐selective channel. OFDM is an orthogonal multicarrier transmission scheme that has subcarriers with sinc‐shaped spectra. The transceiver structure of the OFDM is given in Figure 7.
\n
Figure 7.
OFDM transmission scheme implemented using IDFT/DFT.
\n
Accordingly, a sequence of PSK or QAM symbols is converted into N parallel streams before the N‐point inverse DFT (IDFT) operation. Parallel streams are converted to a serial form after the IDFT operation. The same operations are done at the receiver sides that include DFT operations instead of the IDFT operation.
\n
The advantages and disadvantages of OFDM are as follows:
\n
Advantages:\n
Resilience to frequency selective fading: by dividing the channel into narrow flat fading channels.
Spectrum efficiency: by allowing overlap.
Resilience to interference: by using acyclic prefix (CP) to avoid intersymbol and interframe interferences.
Channel equalization: by using multiple subchannels.
Computationally efficient: by using fast Fourier transform (FFT) and inverse FFT (IFFT) operations to implement modulation and demodulation.
\n
Disadvantages:\n
High peak‐to‐average power ratio (PAPR): because of using independent phases for the subcarriers.
Sensitive to carrier frequency offset (CFO): because of small subcarrier spacing and the necessity of good receiver synchronization.
Out‐of‐band interference: because of the rectangular pulse shape.
Loss of efficiency: because of using the cyclic prefix (CP) and guard intervals (GIs).
\n
Therefore, OFDM is a very useful multicarrier modulation scheme because of its advantages. On the other hand, new modulation schemes are needed to overcome the drawbacks of OFDM.
\n
\n
3.1. Filter bank‐based multicarrier
\n
FBMC is the set of filtering operations that separate the input signal to the subbands with the frequency‐shifted versions of low‐pass prototype filters. The differences of FBMC from OFDM are: (i) CP extension is not required, (ii) having low side lobe and low spectral leakage depends on the filter type, (iii) more complex, and (iv) less sensitive to CFO. The benefits of FBMC are allowing to pulse shaping of filters that produce well‐localized subbands in both time and frequency domain. FBMC is a candidate waveform of 5G communication networks to overcome some problems. The features such as lower side-lobes, lower sensitivity to CFO, and higher bandwidth efficiency—because of the absence of CP—makes FBMC a possible replacement of OFDM in 5G wireless communications. Furthermore, frequency allocations of subbands become more flexible with benefits of filtering operations.
\n
FBMC modulation‐based systems are more complex than OFDM due to exchange of FFT/IFFT operations by the filter banks. The CFO is caused by Doppler shift due to mobility. Orthogonality between adjacent subcarriers is destroyed by CFO and it introduces intercarrier interference (ICI) and intersymbol interference (ISI). Besides, the sinc‐shape frequency response of each subcarrier causes large ICI in presence of CFO. Using the windows with smooth edges reduces the sensitivity of CFO, thus FBMC satisfies this condition.
\n
In the conventional FBMC system, the frequency spectrum is divided into equal subbands and each symbol in subbands is filtered after upsampling operations. The upsampling value (K) and the number of the subbands (M) determine the overlapping of subbands [20] and the allocations of subbands of FBMC are given in Figure 8. When the K equals to the M, the filter bank is said to be critically sampled; otherwise, it is noncritically sampled.
\n
Figure 8.
Frequency allocation of FBMC: the channel is uniformly divided by subbands.
\n
According to the FMT modulation, each user symbols in subbands are filtered by the frequency‐shifted versions of a low‐pass prototype filter after upsampling operations. The transceiver scheme of FMT is given in Figure 9. Here, symbols with the same data rates share frequency spectrum equally.
\n
Figure 9.
The transceiver structure of FMT: symbols are transmitted with multicarrier modulation by filtering. If the low‐pass prototype filters h0(n) are symmetric finite impulse response (FIR) filters, then the transceiver filters are their complex conjugates.
\n
The transmitted signal of the FMT scheme in Figure 9 is given by\n
x(n)=∑m=0M−1∑k=−∞∞A(m)(k)h0(n−kM)ej2πmn/ME13
\n
where h0(n) is the prototype filter. The transmitted signal x(n) is the sum of the convolutions of upsampled of data and the frequency‐shifted versions of a low‐pass prototype filter.
\n
Generally, the bandwidth allocations of users need not be equal to each other because of different data rates. Especially, some users in 5G communication channel may upload their video streams, while some users are a part of internet‐of‐things/machine‐type communications (IoT/MTC). The bandwidth requirements of these users are not the same and may change according to the applications of users. Hence, it is not advantageous to use traditional multicarrier structures for the users that need different transmission bandwidths. In LTE (long‐term evaluation), the frequency spectrum is shared by users with predefined bandwidths (i.e., 1.4, 3, 5, 10, 15, and 20 MHz), which is not a flexible solution for users having different data rate demands. Recent studies on FBMC modulation have not provided an effective remedy for such users. For that reason, FMT modulation can be modified for user demands on different data rates to allow nonuniformly divided bandwidth allocations as proposed by Çatak and Durak‐Ata in [21]. The main contributions of [21] are as follows: (i) the classical FBMC modulation schemes are modified for user demands on data rates. (ii) The assignments of user bandwidths are done at the physical layer. (iii) The bandwidth allocations become adaptive for user requirements instead of system orders.
\n
\n
\n
3.2. FMT with nonuniformly divided bandwidth allocation
\n
The nonuniformly divided bandwidth allocation is important for users with different data rate demands. Data‐rate demands of users depend on their applications. For instance, video streaming applications require higher data rates. On the other hand, machine‐type communications (MTC), sensors, etc., need lower data rates. FMT with nonuniformly divided bandwidth allocation structures can serve to such heterogeneous users and applications in the same transceiver structure and assign users on bandwidth on the physical layer.
\n
Figure 10.
The block diagram of the FMT with nonuniformly divided bandwidth allocation.
\n
The transceiver structure of the FMT multicarrier system for nonuniformly divided bandwidth allocations is given in Figure 10. Each user symbols (A(m)(k)) in subbands are filtered by the frequency‐shifted versions of a low‐pass prototype filter after upsampling operations. The upsampling values and the filter lengths may be different for all subbands.
\n
Figure 11.
Frequency responses of raised cosine filters for different upsampling rates.
\n
In Figure 10, the upsampling operation ↑D is inserting D−1 zeros between consecutive samples. The frequency responses of the raised cosine filter for different upsampling numbers are given in Figure 11. Accordingly, if the sampling rate increases, the frequency resolution will be increased. Thus, the users need less bandwidth. According to the limit of time‐bandwidth product, less bandwidth means longer symbol duration and also high latency.
\n\n
The transmitted signal for FMT with nonuniformly divided bandwidth allocation is given by\n
x(n)=∑m=0M−1∑kϵTmA(m)(k)h0(n−kDm)ej2πmn/ME14
\n
where Dm is the upsampling rate and Tm is the symbol length for the mth user. The prototype filter of impulse response hm(n)=h0(n)ej2πmn/M can be expressed as\n
In the same way, the received signal is obtained by\n
A^(m)(k)=∑l=−∞∞ym(l)gm(lDm−k)e−j2πmlDm/ME17
\n
where gm(lDm−k)=g0(lDm−k)ej2πm(lDm−k)/M. If the transmitter filter h0(n) is assumed to be symmetric, the receiver filter g0(n) equals complex conjugate of h0(n). Finally, the received signal becomes\n
A^(m)(k)=∑l=−∞∞ym(l)hm*(lDm−k)e−j2πmlDm/ME18
\n
\n
\n
3.3. Generalized frequency division multiplexing
\n
GFDM can be considered as type of filter bank-based multicarrier modulation scheme with transmission filters that are shifted in time and frequency domains. This scheme offers more flexible pulse shaping for individual subcarriers [22]. However, GFDM has complicated receiver designs and needs high‐order filtering and tail biting. To simplify transceiver structures, polyphase filters can be employed [10].
\n
The receiver structure of GFDM is given in Figure 12. Accordingly, the data is transmitted with K subcarriers that carry M subsymbols. Data is mapped into the complex valued QAM symbols. The mapped data are upsampled by the factor N, where N=MK. The transmitter filter gk,m[n] with N samples is the time‐ and frequency‐shifted version of g(n) that is expressed by\n
gk,m[n]=g[(n−mK)mod N]exp(−j2πkKn)E19
\n
Figure 12.
The transmitter structure of GFDM: the transmission filters are shifted in time and frequency domains.
\n
where k and m are the subcarrier and subsymbol indices where k=0,1,…,K−1 and m=0,1,…,M−1, respectively. The transmitted signal is given by\n
x[n]=∑m=0M−1∑k=0K−1dk,mgk,m[n]E20
\n
and Eq. (20) can be expressed with modulation matrix as\n
x=AdE21
\n
where x is a vector that contains transmitted samples of x[n] and A is the KM×KM modulation matrix that contains samples of transmitter filter gk,m[n] where\n
The transmitter diagram of GFDM is given in Figure 13. The signal that passes through the channel must be equalized to clarify from the channel effects. If the number of subcarriers is high enough, the channel frequency response can be flat for each subcarrier. Thus, subcarrier bandwidths become smaller than the coherence bandwidth. In such a case, the received signal can be equalized with a zero‐forcing equalizer. According to the zero‐forcing equalizer, inverse of the frequency response of the channel is applied to the received signal. The implementation is simple for flat channels; otherwise, it becomes very hard due to inversing operations. The signal that passes through the channel is\n
y[n]=h[n]*x[n]+w[n]E23
\n
Figure 13.
The receiver structure of GFDM with equalizer and detector.
\n
where w[n] is the additive noise and c[n] is the impulse response of channel. The equalized signal with zero‐forcing equalizer is given by\n
requal[n]=IDFT{Y(ejω)H(ejω)},E24
\n
where Y(ejω) and C(ejω) are the corresponding frequency responses. After equalization procees, the received signal can be estimated by a detection process. Zero‐forcing receiver, matched‐filter receiver, and minimum mean square error (MMSE) receiver structures are common detection methods.
\n
Zero‐forcing receiver is based on the inverse of modulation matrix in Eq. (21). Accordingly, the detected signal is\n
d^zero−forcing=A−1requalE25
\n
where A−1 is the inverse matrix of the modulation matrix A and requal is the equalized signal. The pseudo‐inverse matrix can be used for the nonsquare case of A. The pseudo‐inverse of A can be evaluated by\n
A+=AH(AAH)−1E26
\n
where AH is Hermitan matrix of A. Then, the detected signal by zero‐forcing receiver in Eq. (25) becomes\n
d^zero−forcing=AHrequal.E27
\n
Matched‐filter receiver maximizes the SNR per subcarrier. The detected signal by the matched‐filter receiver is given by\n
d^match−filtering=AHrequalE28
\n
According to MMSE receiver, the detected signal is given by\n
d^MMSE=A†requalwith A†=(σ2nσ2dI+AHA)−1AHE29
\n
where σ2n and σ2d are the variance of the noise and data symbol.
\n
Briefly, zero‐forcing receiver extracts the channel effects from the transmitted signal and removes all ISI for ideal noiseless channel condition. It amplifies the noise for noisy channels. The matched‐filter receivers overperform the zero‐forcing receiver in low SNR regime. Matched‐filter receiver suffers from self‐interference. On the other hand, MMSE receiver is successful at high and low SNR similar to zero‐forcing receiver and matched‐filter receiver, respectively [23].
\n
\n
\n
\n
4. Performance evaluation
\n
The waveform design issues depend on the requirements of users, communication types, and communication networks. These requirements are changing and evolving every year. Today, on the verge of 5G communication technology, most important requirements are data rate, latency, power, efficiency, complexity, and robustness to the channel [24]. Also, there are some design issues to execute these technology requirements. PAPR, OOB emission, interferences, and complexity issues are investigated and their importance is verified.
\n
The PAPR is the ratio of peak power to the average power of a transmitted signal. A multicarrier signal consists of lots of modulated signals in each subcarrier, which can cause large PAPR value after addition. The comparisons of GFDM and OFDM on PAPR performances are given in Figure 14. Accordingly, the PAPR values of GFDM are better than OFDM. Low PAPR is important to reduce hardware cost and power consumption. One advantage of GFDM over OFDM is obviously in reducing the OOB radiation.
\n
Figure 14.
The comparison of PAPR of GFDM and OFDM: the PAPR of GFDM is less than OFDM. If multicarrier signals are summed up with same phases, the PAPR values increase [25].
\n
The out‐of‐band (OOB) emission is the emission outside the necessary bandwidths. It causes waste of spectral resources and serious interference problems to adjacent wireless channels. These redundant emissions cause interference. Interference between carriers (ICI) and symbols (ISI) are two issues of waveform design. ICI is caused by channel frequency offsets and it is one of the major problems of OFDM. It can be avoided by frequency domain equalization, time domain windowing, and using redundant subcarrier between carriers. ISI is caused by the dispersion of the channel. It can be avoided by leaving enough space in between the transmitted symbols.
\n
In Figure 15, OOB emissions of OFDM symbol and FBMC symbol are given comparatively. Here, OFDM suffers from high‐level OOB emission. Conversely, filter bank‐based operations allow lower out‐of‐band emissions.
\n
Figure 15.
Power spectrum density of OFDM and FBMC symbols: FBMC scheme allows lower out‐of‐band emissions.
\n
Complexity is defined by the total number of operations in the transmitters and receivers. The transmitter structures must be adapted to channel conditions and provide easy detection. Filtering operations make the systems more complex. Polyphase filter structures are used to overcome these problems. Another issue is channel equalization at the receivers while taking the inverse of a matrix. The performance evaluations are summarized in Table 2.
This chapter presents the requirements of 5G communication systems and the fundamentals of waveform design to cover them for 5G wireless communication networks. According to the report of 5G PPP Architecture Working Group, the 5G network will “operate in a wide spectrum range with a diverse range of characteristics” [26]. Accordingly, the 5G communication channel will be heterogeneous and will provide users with different demands. The waveform design part of the physical layer is a critical issue in meeting the new demands and requirements, such as low latency, low power consumption, high data rates, and spectrum efficiency. TF lattice structures and pulse shaping must be determined. The transmission scheme, time and frequency allocation of symbols, resolution in time and frequency, and time‐bandwidth product are the design criteria of time frequency lattice structures. Also, pulse shaping is the filtering process that maps the modulated signals to the TF lattice to control the interferences. Besides, transceiver scheme of some candidate waveforms and performance evaluations are given. Accordingly, OFDM has an easy implementation, but the high level of OOB emission and PAPR value. The waveforms that include filtering have lower OOB emission but high complexity.
\n
In this chapter, the waveform design is assumed to be performed at baseband. On the other hand, one of the potential of 5G communication technologies under consideration is the use of millimeter wave frequencies. In this way, signals allocate more bandwidths to faster transmission, high‐resolution video broadcasting, etc. Massive‐MIMO and advanced beamforming technologies will allow high data rate.
\n
\n\n',keywords:"waveform design, orthogonal frequency division multiplexing (OFDM), filtered multitone (FMT), time‐frequency lattice, pulse shaping, multicarrier modulation, generalized frequency division multiplexing (GFDM)",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/52919.pdf",chapterXML:"https://mts.intechopen.com/source/xml/52919.xml",downloadPdfUrl:"/chapter/pdf-download/52919",previewPdfUrl:"/chapter/pdf-preview/52919",totalDownloads:3440,totalViews:507,totalCrossrefCites:1,totalDimensionsCites:2,totalAltmetricsMentions:0,impactScore:1,impactScorePercentile:70,impactScoreQuartile:3,hasAltmetrics:0,dateSubmitted:"April 22nd 2016",dateReviewed:"September 28th 2016",datePrePublished:null,datePublished:"December 14th 2016",dateFinished:"November 10th 2016",readingETA:"0",abstract:"In this chapter, we first introduce new requirements of 5G wireless network and its differences from past generations. The question “Why do we need new waveforms?” is answered in these respects. In the following sections, time‐frequency (TF) lattice structure, pulse shaping, and multicarrier schemes are discussed in detail. TF lattice structures give information about TF localization of the pulse shape of employed filters. The structures are examined for multicarrier, single‐carrier, time‐division, and frequency‐division multiplexing schemes, comparatively. Dispersion on time and frequency response of these filters may cause interference among symbols and carriers. Thus, effects of different pulse shapes, their corresponding transceiver structures, and trade‐offs are given. Finally, performance evaluations of the selected waveform structures for 5G wireless communication systems are discussed.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/52919",risUrl:"/chapter/ris/52919",book:{id:"5480",slug:"towards-5g-wireless-networks-a-physical-layer-perspective"},signatures:"Evren Çatak and Lütfiye Durak‐Ata",authors:[{id:"19414",title:"Prof.",name:"Lutfiye",middleName:null,surname:"Durak-Ata",fullName:"Lutfiye Durak-Ata",slug:"lutfiye-durak-ata",email:"lutfiye@ieee.org",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/19414/images/4565_n.jpg",institution:{name:"Istanbul Technical University",institutionURL:null,country:{name:"Turkey"}}},{id:"189749",title:"M.Sc.",name:"Evren",middleName:null,surname:"Çatak",fullName:"Evren Çatak",slug:"evren-catak",email:"evrensakar@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Fundamentals of waveform design",level:"1"},{id:"sec_2_2",title:"2.1. TF lattice structures",level:"2"},{id:"sec_3_2",title:"2.2. Pulse shaping",level:"2"},{id:"sec_5",title:"3. Transceiver schemes for 5G wireless networks",level:"1"},{id:"sec_5_2",title:"3.1. Filter bank‐based multicarrier",level:"2"},{id:"sec_6_2",title:"3.2. FMT with nonuniformly divided bandwidth allocation",level:"2"},{id:"sec_7_2",title:"3.3. Generalized frequency division multiplexing",level:"2"},{id:"sec_9",title:"4. Performance evaluation",level:"1"},{id:"sec_10",title:"5. Conclusion and future directions",level:"1"}],chapterReferences:[{id:"B1",body:'Wunder G et al.: 5GNOW transceiver and frame structure concept. 5th generation non‐orthogonal waveforms for asynchronous. Signalling (5GNOW) Project Report. 2015:D3.3\n'},{id:"B2",body:'Schaich F, Ringset V, Bellanger M, Zhang D, Ruyet D L: Compatibility of OFDM and FBMC systems and reconfigurability of terminals. Physical Layer for DYnamic AccesS and Cognitive Radio (PHYDYAS) Project Report. 2009:D7.1\n'},{id:"B3",body:'Chen T, Matinmikko M, Chen X, Zhou X, Ahokangas P: Software defined mobile networks: concept, survey, and research directions. IEEE Communications Magazine. 2015;53(11):126–133\n'},{id:"B4",body:'Andrews J G, Buzzi S, Choi W, Hanly S, Lozano A, Soong A C K, Zhang J C: What will 5G be? IEEE Journal on Selected Areas in Communications. 2014;32(6):1065–1082\n'},{id:"B5",body:'Wunder G, Jung P, Kasparick M, Wild T, Schaich F, Chen Y, Brink S, Gaspar I, Michailow N, Festag A, Mendes L, Cassiau N, Ktenas D, Dryjanski M, Pietrzyk S, Eged B, Vago P, Wiedmann F: 5GNOW: Non‐orthogonal, asynchronous waveforms for future mobile applications. IEEE Communications Magazine. 2014:52(2):97–105\n'},{id:"B6",body:'Siohan P, Lin H. An advanced multi‐carrier modulation for future radio systems. In IEEE International Conferance on Acoustics, Speech and Signal Processing(ICASSP); 2014.\n'},{id:"B7",body:'Van De Beek J, Berggren F: Out‐of‐band power suppression in OFDM. IEEE Communications Letters. 2008:12(9):609–611\n'},{id:"B8",body:'Hee Han S, Hong Lee J: An overview of peak‐to‐average power ratio reduction techniques for multicarrier transmission. IEEE Wireless Communications. 2005:12(2):56–65\n'},{id:"B9",body:'Farhang-Boroujeny B: Filter bank multicarrier modulation: a waveform candidate for 5G and beyond. Advances in Electrical Engineering. 2014. 25 pages. Article ID 482805–25.\n'},{id:"B10",body:'N. Michailow et al.: Generalized frequency division multiplexing for 5th generation cellular networks. IEEE Transactions on Communications. 2014:62(9); pp. 3045–3061.\n'},{id:"B11",body:'Farhang A, Marchetti N, Doyle L E: Low complexity transceiver design for GFDM. In arXiv: 1501.02940 [Online] available: http://arxiv.org/abs/1501.02940, 2015\n'},{id:"B12",body:'Vakilian V, Wild T, Schaich F, Brink S T, Frigon J F: Universal‐filtered multi‐carrier technique for wireless systems beyond LTE. In IEEE Globecom Workshops (IEEE GC Wkshps); 2013:pp. 223–228\n'},{id:"B13",body:'Schaich F, Wild T. Waveform contenders for 5G – OFDM vs. FBMC vs. UFMC. In IEEE, Communications, Control and Signal Processing (ISCCSP); 2014; p. 457–460\n'},{id:"B14",body:'Gabor D: Theory of communication. Part 1: the analysis of information electrical engineers—Part III: radio and communication engineering. Journal of the Institution of Electrical Engineers; 1946:93(26):429–441\n'},{id:"B15",body:'Boashash B. Time-frequency signal analysis and processing: a comprehensive reference. First ed. Hungary:Academic Press; 2003.\n'},{id:"B16",body:'Michailow N, Fettweis G. Low peak-to-average power ratio for next generation cellular systems with generalized frequency division multiplexing. In International Symposium on Intelligent Signal Processing and Communications Systems (ISPACS); 2013; pp. 651–655.\n'},{id:"B17",body:'Aldirmaz S, Serbes A, Durak-Ata L: Spectrally efficient OFDMA lattice structure via toroidal waveforms on the time-frequency plane. EURASIP Journal on Advances in Signal Processing. 2010:14 pages. DOI: 10.1155/2010/684097\n'},{id:"B18",body:'Han F M, Zhang X D: Hexagonal multicarrier modulation: a robust transmission scheme for time‐frequency dispersive channels. IEEE Transactions on Signal Processing. 2007:55(5):1955–1961\n'},{id:"B19",body:'Senay S, Durak L, Chaparro L F: A time‐frequency division multiplexing communications system with hexagonal lattice structure. In Signal Processing Conference; 2009: pp. 1186–1189\n'},{id:"B20",body:'Amini P, Farhang-Boroujeny B: Packet format design and decision directed tracking methods for filter bank multicarrier systems. EURASIP Journal on Advances in Signal Processing. 2010:13 pages. DOI: 10.1155/2010/307983\n'},{id:"B21",body:'Catak E, L. Durak‐Ata L: Filtered multitone system for users with different data rates at 5G wireless networks. In IEEE Signal Processing and Communication Application Conference (SIU); 2016; pp. 741–744\n'},{id:"B22",body:'Michailow N, Datta R, Krone S, Lentmaier M, Fettweis G: Generalized frequency division multiplexing: A flexible multi‐carrier modulation scheme for 5th generation cellular networks. in German Microwave Conference (GeMiC); 2012\n'},{id:"B23",body:'Michailow N, Krone S, Lentmaier M, Fettweis G: Bit error rate performance of generalized frequency division multiplexing. In IEEE Vehicular Technology Conference (VTC); 2012; pp. 1–5\n'},{id:"B24",body:'Long Bao Le et al.: Enabling 5G mobile wireless technologies. EURASIP Journal on Wireless Communications and Networking. 2015;218:14 pages. DOI:10.1186/s13638-015-0452-9\n'},{id:"B25",body:'Fettweis G, Krondorf M, Bittner S: GFDM‐Generalized frequency division multiplexing. In IEEE Vehicular Technology Conference (VTC); 2009; pp. 1–4\n'},{id:"B26",body:'“View on 5G architecture,” 5G PPP Architecture Working Group, Version 1.0 July 2016.\n'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Evren Çatak",address:null,affiliation:'
Department of Electronics and Communications Engineering, Yıldız Technical University, Istanbul, Turkey
Informatics Institute, Istanbul Technical University, Istanbul, Turkey
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1. Introduction
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The methanogens are one of the primitive life forms on earth which have evolved to be able to thrive in extreme harsh temperatures (severe hot and cold) and living conditions (salt and pH) uninhabitable for most of other life forms. Although a vast proportion of methanogens are Archaea but protists like algae, fungi and protozoa also form a diversity of this group. Besides their anthropogenic existence, methanogens are present in a wide area of ecological niches ranging from peat bogs to deep sea sediments and hydrothermal vents and hot springs [1, 2].
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The large number of microbial population in natural anaerobic systems remains unexplored as enumeration techniques like selective enrichment, pure-culture Isolation, most-probable number estimates are time consuming and labor intensive. Culture less approaches has allowed deciphering the diversity of microbial community thriving across wide environmental ranges. Various anaerobic culture techniques led to the discovery of a third microbial kingdom, the Archaebacteria, which includes methanogens [3, 4]. Further the target specific sequence analysis of 16S rRNA gene in 1970’s had redefined taxonomy of all living organisms into three main domains. Methanogens belong to the 3rd domain of life-Archaea, other two being—Eucarya and Bacteria. Archaea is further divided into phylums Crenarchaeota and Euryarchaeota [5].
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2. Major rumen microbes
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At any time there are billions of any species of anaerobic bacteria and facultative anaerobic bacteria residing in rumen along with a mixed population of various anaerobic protozoa, anaerobic fungi and flagellates making it a diverse microbial consortium in nature. The bacteria along with protozoa make most of the microbial mass (nearly 80%) inside rumen. The bacteria present in specialized niches are a very small fraction that cannot be recovered by cultural methods and even among cultivable bacteria true number of diversity is now revealed only by molecular techniques [6]. The bacteria can further be cellulolytic (fiber digesting), amylolytic (starch and sugar digesting) and lactate utilizing bacteria. The role of symbiotic microbial ecosystem consisting of bacteria, protozoa and fungi is of great significance in ruminants. Phylum Euryarchaeota within domain Archaea includes 7 orders—Methanobacteriales, Methanomicrobiales, Methanococcales, Methanopyrales, Methanocellales, Methanosarcinales and Methanomassiliicoccales. The orders are further divided into 10 families and 31 genera [7, 8, 9].
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3. Methane production in ruminants and its contribution to greenhouse gases
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Methane is a main byproduct of digestion in ruminants produced by the microbial fermentation of plant biomass. Methanogens ferment the ingested feed into short chain fatty acids which consists of 70% of the total metabolizable energy source for ruminants. The methane is specifically produced by methanogens (Archaea) that resides symbiotically in the gut of ruminants by using hydrogen produced by bacteria, fungi and protozoa and reducing CO2 to methane. It is not used by ruminants and is lost in environment through eructation resulting in a loss of 2–12% of metabolic energy intake to the host [10, 11]. Among agricultural sources, enteric fermentation along with natural and man-made wetlands, animal wastes; paddy fields contribute to the release of major amount of methane in environment. Methane gas has a major global warming impact [12]. According to the fifth assessment report of Intergovernmental Panel on Climate Change (IPCC) published in 2014, global release of greenhouse gases from enteric fermentation grew from 1.4 to 2.1 GtCO2eq/yr between 1961 and 2010. The largest methane emission was by cattle (75% of the total) followed by goat, sheep and other ruminants during the year 2000–2010 [13]. The enteric fermentation in ruminants is a significant cause of methane emission in environment. It is an inevitable outcome of their normal digestive process [14], which is not used by them and is lost in environment. Since, methane is a potent greenhouse gas, to reduce the activity and number of methane producing Archaea, it is desirable to have knowledge about the community structure of methanogens and their feed conversion energy mechanism. In order to control various ruminal disorders the insight into microbial ecology will help to develop nutrition and feed management strategies.
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4. Methanogenic archaeal population in gastro-intestinal tract of ruminants
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The rumen was the initial environment of Archaea which is comprehensively investigated and studied. Hungate [15] reported that about 23 bacterial species played prominent role in ruminal metabolism whereas in 1996 the number increased up to 200 [16]. The culture based techniques had serious limitations as they failed to differentiate between two phylogenetic diverse species along with the dire need of maintaining anaerobic environment to culture and isolate bacteria. The 16S rRNA sequencing technology has been far and wide used to explore the methanogens residing inside rumen and to characterize and validate their community structure and taxonomic composition in evolutionary timeline. The methanogenic group in gastrointestinal tract of ovine, caprine and bovine using rRNA targeted oligonucleotide probes were identified and Methanobacteriales were reported to be the abundant methanogens in bovine and caprine rumen whereas Methanomicrobiales was found to be predominant in ovine rumen [17]. In 2000, the population of methanogens among rumen microbial diversity of sheep in Japan was reported using 16S rDNA cloning and fluorescence in situ hybridization (FISH) technique and most of the clones were found associated with Methanomicrobium mobile, Methanobrevibacter ruminantium and Methanobrevibacter smithii. The total methanogens accounted for 3.6% from the total microorganisms present in rumen and population of M. mobile among methanogens was found to be 54% [18]. A year later the archaeal libraries generated from the rumen of dairy Holstein cows from Japan revealed two groups of sequences produced from two different sets of archaeal primers. The library generated from primers-D30 and D33, revealed 21% of clones related to M. mobile and 79% of clones were anaerobic digester associated archaeal sequences with close identity to Thermoplasma. The second library generated from 0025e and 1492 primers showed 56% of the clones related to M. mobile, 20% related to the Thermoplasma associated sequences and 16% related to Methanobrevibacter spp. and 2 sequences were related to the unidentified rumen Archaea [19].
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Similarly in bovine rumen, 41 cloned sequences were identified in 3 clusters. The largest cluster contained 24 clones with 2 distinct sub clusters with sequences affiliated with Mbb. ruminantium. The sub cluster Mbr I contained nine 16S rDNA sequences that had 98.5–98.8% sequence identity to Mbb. ruminantium whereas the sub cluster Mbr II contained 15 cloned sequences that had 97.2–97.7% similarity to Mbb. ruminantium whereas the second cluster contained 11 cloned sequences having similarity values of 96.1–97.5% to Methanosphaera stadtmanae, an organism first time recognized in rumen. The third cluster was found containing 6 cloned sequences that were 89% similar to Methanosarcina sp. str. WH1 and Methanosarcina thermophila indicating it to be comprised of a novel group of rumen methanogens [20]. In Japan, clones were deduced from bovine rumen that was 83.9–88.3% identical to Mbb. ruminantium [21]. In 2004, the archaeal populations from three fractions of rumen-rumen fluid, rumen solid and rumen epithelium from Korean Hanwoo cattle was constructed using 16S rDNA gene clone libraries. Species belonging to the family Methanomicrobiaceae were found dominant in fractions of fluid and epithelium in rumen while Methanobacteriaceae was abundant in solid fraction of rumen [22]. The Methanomicrobium phylotype was the most abundant phylotype among methanogenic population in rumen of Murrah buffaloes from India as revealed by constructing 16S rDNA gene library. A total of 15 phylotypes out of 17 were affiliated to M. mobile; one sequence was identical to T. acidophilum and one sequence with Methanocorpusculum bavaricum [23]. Methanobacteriales was a dominant order identified from the rumen of Surti buffaloes in India by cloning and sequencing of mcrA gene while in an another study on Murrah buffaloes 100% sequence similarity was reported by two isolates to Mbb. smithii and 100% sequence similarity by one isolate to M. mobile based on 16S rRNA [24, 25].
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5. Effect of diet on diversity of rumen methanogens
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The rumen is a dynamic system therefore the microbes must change qualitatively and quantitatively in response to the changes in the chemical composition of diet of animal rather than geographical location in general. Wang et al [26] reported members of the order Rumen Cluster C (RCC) to be most abundant ruminal methanogen present in cattle from China fed agricultural residues like corn stover, rapeseed and cottonseed meals followed by the order Methanobacteriales. By constructing a gene clone library of mcrA gene, they found that by increasing the agricultural residues in diet of cattle, the methanogen community structure did not change however methane production was increased. The effect of diet on rumen methanogen population has also been studied in Western Australia where sheep were fed different diets. Analysis revealed that archaeal diversity in sheep from grazing pasture was more as compared to sheep fed forage diets-oaten hay or lucerne hay. The maximum numbers of clones identified were from Methanobrevibacter strains SM9, M6, and NT7 [27].
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A corn and cottonseed diet of cattle from Jinnan region of China also reported members of Methanobrevibacter, Methanobacterium, Methanosphaera, Methanomicrobium and unidentified Euryarchaeota. Overall, Methanobrevibacter spp. appeared to be predominant in all three rumen fractions [28]. Similarly, methanogenic population in dairy cattle from Canada was estimated that were fed diets supplemented with enzyme additive by PCR-DGGE and quantitative real-time PCR (qRT-PCR) analysis. The PCR-DGGE profiles were made up of 26 different bands, with two bands affiliated to Methanogenic archaeon CH1270 and one band to Mbb. gottschalkii strain HO. Three bands similar to Methanogenic archaeon CH1270 or Mbb. smithii ATCC 35061 appeared after enzyme was supplemented [29]. The diversity of rumen methanogens present in Mediterranean water buffaloes from Brazil which were maintained on three different diets-corn silage (library 1), pasture grazing (library 2) and sugar cane (library 3) revealed all three 16S rRNA clone libraries to be consisted of Methanobrevibacter-related sequences. The abundance of Methanobrevibacter like sequences in water buffaloes was in contrast to previous reports that showed M. mobile like methanogens to be predominant Archaea isolated from water buffaloes of Murrah and Surti breeds from India [30]. The taxonomy and structure of methanogens in Swedish dairy cattle fed two different diets through clone library consisted by terminal restriction fragment length polymorphism (T-RFLP) showed the genus Methanobrevibacter to be dominant in rumen and that the diet may not be an obvious factor affecting the community composition of methanogenic population inside rumen but may give an insight to the structure of ruminal methanogens [31].
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Another study on sheep in Queensland, Australia in 2006 revealed 78 clones of 26 different methanogen related sequences were obtained. Eight sequences consisted of 15 clones were found 95–100% similar to the orders Methanobacteriales and Methanomicrobiales, and rest 18 sequences consisted of 63 clones were 72–75% affiliated to Thermoplasma acidophilum (T. acidophilum) and Thermoplasma volcanium (T. volcanium) [32]. The structure of archaeal diversity in feedlot cattle (starch based diet) from two different provinces of Canada-Ontario and Prince Edward Island, were deduced by constructing a clone library of 241 sequences. Eleven phylotypes (38 clones) in cattle from Ontario region (corn-based diet) were unique to this group as they were not found in cattle from Prince Edward Island. Similarly, 7 phylotypes (42 clones) from Prince Edward Island cattle (potato by-products) were found only in this group whereas 5 sequences representing 161 clones were found common in both herds. Out of 23 different sequences obtained, 10 sequences consisting of 136 clones were 89.8–100% affiliated to the species of the orders Methanobacteriales, Methanomicrobiales and Methanosarcinales and remaining 13 sequences consisting of 105 clones showed 74.1–75.8% sequence similarity to the species T. volcanium and T. acidophilum [33]. The dominance of total rumen Archaea from different ruminant species around the world in a global data set report surveying nine studies assessed that genus Methanobrevibacter (61.6%), Methanomicrobium (14.9%) and uncultured species from Rumen Cluster C (15.8%) constituted 92.3% of total rumen Archaea [34]. Another study from Venezuela indicated Methanobrevibacter phylotype to be the most abundant genera in 14 different 16S rRNA gene sequences or phylotypes from 104 clone library constructed in sheep [35]. The rumen of Sika deer fed oak leaf diet and corn stalk diet from China revealed thirty six OTUs assigned to 146 unique sequences and in both the diet group, genus Methanobrevibacter was detected as a predominant methanogen. Among the species, Mbb. millerae was most abundant in both groups but accounted for a slightly higher population (69.5%) in corn stalk library than in oak leaf library (51.4%). Clones with similarity to Mbb. smithii like clones and Mbb. ruminantium like clones were present in corn stalk library but were absent in oak leaf library [36].
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The majority of sequences were related to genera Methanobrevibacter and Methanosphaera and a group of novel uncultured methanogens “uncultured marine bacteria” were identified in Moxoto breed goats from Brazil by constructing 16S rRNA gene clone libraries [37]. Likewise, the archaeal methanogen population inside rumen of lactating Jersey and Holstein cattle fed same diet from America revealed species level similarity to Mbb. ruminantium [38]. The community structure of methanogens inside rumen of farmed sheep, cattle and red deer which were fed different diets revealed diet and host based differences in framing community structure, but the presence of dominant archaeal species was uniform in all host animals. The dominant members were from following clades: RO clade-Mbb. ruminantium and Mbb. olleyae, SGMT clade-Mbb. gottschalkii, Mbb. millerae and Mbb. thaueri and species of the genus Methanosphaera [39].
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6. Methanogen diversity inside rumen and/feces under similar conditions of diet
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The sequences obtained from rumen and feces of local sheep from Xinjiang, China were divided into three groups based on their affiliation to the following genera: Methanobrevibacter, Methanocorpusculum and an unclassified methanogen-like group [40]. Order Methanobacteriales was found to be dominant in rumen of faunated and unfaunated Holstein cattle from Japan by constructing clone libraries from 16S rDNA gene and mcrA gene [41]. The methanogenic archaeal population in sheep of Scottish uplands were illustrated by Snelling et al. [42] by different methods-Sanger amplicon sequencing by constructing 16S rRNA gene libraries, 16S rRNA gene amplicon sequencing by Illumina, Illumina metagenome sequencing. All the methods revealed the order Methanobacteriales containing genera: Methanobrevibacter, Methanosphaera and Methanobacteria to be the most abundant. Among the Methanobacteriales order, Mbb. millerae comprised of ≥91% of OTU’s and remainder of the OTU’s were formed by Methanosphaera.
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Tymensen and McAllister [43] reported the archaeal spp. linked with ruminal protozoa in cattle and obtained 276 final sequences generated from clone libraries using five diverse universal archaeal primer pairs and found that the three genera/taxa viz. Methanobrevibacter, Rumen Cluster C (RCC) and Methanomicrobium accounted for 94–100% of the sequences in each library. Metatranscriptomics approach-Illumina deep-sequencing with overlapping read paired-end technology revealed that Bacteria and Eukaryotes contributed to the majority of ribotags (approximately 50%) whereas Archaea contributed only 1% of ribotags mainly comprised of the order Methanobacteriales (Methanobrevibacter and Methanosphaera) and RCC Thermoplasmata. The RCC Thermoplasmata lowered down considerably on rape seed oil (RSO) supplementation whereas Methanobacteriales did not show any decrease. A notable decrease in the mcrA and mcrB transcripts of RCC on change in was noticed suggesting the reduced CH4 emissions [44].
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The abundance of two archeal orders-Methanobacteriales and Methanomassiliicoccales in rumen of sheep and cattle from New Zealand were studied. From the order Methanobacteriales, sequences were assigned to only four species—Mbb. gottschalkii, Mbb. ruminantium, Methanosphaera sp. ISO3-F5 and Methanosphaera sp. group5. The members of the order Methanomassiliicoccales contributed 10.4% of the total relative abundance of the methanogenic archaeal community, Methanobacteriales (89.6%) being dominant [45]. The methanogenic Archaea in yak from China grazing on natural pastures exhibited the species of the family Methanobacteriaceae to be predominant in yak rumen followed by members from the family Methanomassiliicoccaceae and Methanosarcinaceae [46].
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The archaeal methanogenic community from rumen of two indigenous ruminant species-yak and Tibetan sheep and two introduced species-cattle and crossbred sheep in Qinghai-Tibetan plateau from China under similar diet of oaten hay and barley and environmental conditions revealed the more archaeal diversity in indigenous species than in introduced species. Methanomassiliicoccaceae was predominant family representing most of the sequences while Methanobacteriaceae was second most dominant archaeal family. Among Methanobrevibacter genus, Mbb.\ngottschalkii and Mbb. ruminantium were the most observed species. Interestingly, Mbb. woesei and Mbb. sp. RT were only found associated with yak rumen [47]. Salgado-Flores et al. [48] reported archaeal methanogenic density by quantitative real-time PCR and diversity from rumen and cecum samples of Norwegian reindeer fed on standard pellets and lichens by 454 pyrosequencing of 16S rRNA genes. The population density of archaeal methanogens remained almost constant for both the diets in rumen and cecum samples. In rumen samples, Methanobrevibacter was found to be main genus and strain Mbb. thaueri CW to be predominant in both groups fed different diets. Mbb. wolinii SH was second most abundant species found in group fed pellet based diet whereas constituted only 1.5% of the total sequences in group fed lichens. The second most prevalent species was Mbb.\nruminantium strain M1 in reindeers fed lichens but accounted only 4.2% of the total sequences in pellet fed group of reindeers. In cecum samples also, genus Methanobrevibacter was detected predominantly in both the groups. Mbb. millerae strain ZA-10 was found to be most abundant in reindeer group fed with pellet but had less than 97% similarity with this archaeal methanogen whereas strain Mbb. thaueri CW was main species in lichen fed group with 98% similarity. Franzolin and Wright reported that the density of archaeal methanogens was very low as compared to bacterial counterparts in grazing and feedlot group of buffaloes from Brazil. The density of methanogens as compared to bacteria in reticulum was more as compared to rumen [49].
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The rumen methanogenic structure in three Indian cattle and buffaloes which were fed on wheat straws based diet using RT-PCR revealed most abundant orders of Methanomicrobiales and Methanobacteriales along with total bacteria and that it remained constant for two animals using a particular diet [50]. Similarly, the ruminal diversity in Indian Murrah buffaloes by using amplified ribosomal DNA restriction analysis (ARDRA) maintained under standard diet of wheat straws revealed a total of 108 clones that were classified into 16 phylotypes. The 9 phylotypes showed less than 97% sequence similarity to any of the cultivated methanogen strain and represented a novel uncultured group of methanogens. The second group comprised of 4 phylotypes that showed 92–99% sequence similarity with M. mobile. The third group consisted of a single phylotype clustered with M. burtonii, reported for the first time in rumen. The fourth group was a single phylotype that showed 97% sequence identity with Mbb. gottschalkii. The last group of single phylotype showed a sequence similarity to Mbb. ruminantium [51].
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Likewise, the comparative diversity analysis of methanogens using 16S rRNA and mcrA in cattle rumen fed on a high fiber diet reported 13 OTU’s consisting of 102 clones from 16S rRNA gene based library. All OTU’s were clustered with order Methanobacteriales and were further splitted into Cluster I that had 12 OTU’s related to Methanobrevibacter spp. and Cluster II comprised of one OTU related to M. stadtmanae [52]. The Surti buffaloes that were fed wheat straw and compound concentrate mixture diet generated a total of 76 clones representing 21 sequences based on PCR-RFLP patterns. BLAST analysis revealed 13 OTU’s (55 clones) that showed sequence identity with Methanomicrobium sp., 3 OTU’s (15 clones) that showed sequence similarity with Methanobrevibacter sp. The remaining 5 OTU’s (6 clones) were associated with uncultured Archaea. Overall, the methanogenic population inside rumen of buffaloes was from the order of Methanomicrobiales (18 OTUs) and Methanobacteriales (3 OTUs) [53]. The rumen metagenome of buffalo using q-PCR were compared with MG-RAST based annotation of the metagenomes sequences of 16S rDNA amplicons and high throughput shotgun sequencing and found Methanomicrobiales in lower number [54] (\nFigure 1\n).
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Figure 1.
A phylogenetic tree based on 16S rRNA sequences obtained from camel foregut and reference sequences downloaded from NCBI Genbank database [58].
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7. Methanogenic archaeal population in pseudo ruminants like camelids
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Gut methanogens remains largely uncharacterized in camel with no published studies on methanogenic archaeal populations from 16S rRNA gene clone libraries whereas much interest has been paid to domestic ruminants. The community diversity and structure of archaeal methanogens in fecal samples of Bactrian camel (Camelus bactrianus) maintained at two zoos from United States of America revealed the genus Methanobrevibacter to be the abundant ruminal methanogen however the diversity and structure of methanogens varied significantly between the two libraries with only 2 OTU’s in common to both the libraries. Two and seven OTU’s were found unique to first and second library, respectively [55]. The methanogenic archaeal population inside rumen of Alpaca (Vicugna pacos) from America resulted in a 947 non chimeric gene clone library representing 51 distinct OTU’s. Thirty seven OTU’s displayed ≥95% genus-level sequence affiliation with the species belonging to Methanobrevibacter. Six out of 37 OTU’s showed ≥98% species-level sequence identity to Mbb. millerae; 2 OTU’s showed species-level identity to Mbb. ruminantium; 2 OTU’s showed >98% identity to Mbb. smithii; 27 OTU’s showed 95–97.9% sequence similarity to well detected and reported Methanobrevibacter species. Of the remaining 14 OTU’s, 3 distinct phylogenetic group were made that consisted of 4 OTU’s that had 95–97.9% similarity to the species of Methanobacterium; other 3 OTU’s showed genus level similarity with the species of Methanosphaera; 7 OTU’s were found to be isolated phylogenetically from order Methanobacteriales. Overall, Methanobrevibacter was found to be dominant in alpaca rumen like other ruminants but in contrast as described in other ruminants Mbb. millerae was found to be in most number of clones showing species level identity [56]. The fecal microbiome of camels maintained at intensive and extensive system of management in Jaisalmer (Rajasthan) was evaluated through non-cultural approach. The both group’s fecal metagenomes were compared with available fecal or rumen metagenomes on MG-RAST and Mbb. smithii was detected as a predominant archaeal methanogen [57]. A 16S rRNA gene clone library from the content of the C1 compartment (foregut) of Indian camels was constructed by cloning pooled polymerase chain reaction (PCR)—amplified products. The sequences (n = 151) were clustered into 15 OTU’s (operational taxonomic units) based on sequencing of unique RFLP pattern and divided into five species groups: Methanobrevibacter (Mbb.) millerae strain SM9, “Candidatus” Methanoplasma termitum, Mbb. smithii, Mbb. ruminantium, Methanocorpusculum (M.) bavaricum strain DSM 4179. The genus Methanobrevibacter (order Methanobacteriales) was the most prevalent (76.82%), followed by Archaea from the orders Methanomassiliicoccales (17.21%) and Methanomicrobiales (5.96%) [58] (\nFigure 1\n).
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8. Biotechnological applications of extremophiles
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The microbial diversity of extremophiles is of interest particularly for microbiologists and biotechnologists to decipher the enzymes and their functions, their biochemical and metabolic pathways that enable them to survive in harshest conditions. The in depth knowledge will pave the path for creating technologies that can function under extreme conditions. It will improve our current knowledge and perception about the interrelationships between various species and will continue to lead to the classification and assessment of ruminal archaeal species.
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For researchers working to explore the microbial ecology of volcanic systems, deep under the earth, oceans, thermal vents, rice fields, waste treatments, bioremediation of soils, the rumen forms a stable and basic source of knowledge concerning anaerobic microorganisms. The knowledge of anaerobic microorganism’s reaction going inside rumen flora is of invaluable importance as methanogens are also found in omnivores and humans alike and can be implicated in understanding human and animal diseases. An extensive understanding of methanogens in gastrointestinal tract will contribute to the sustainable farming of animals well into the future. The enteric fermentation in ruminants is a significant cause of methane emission in environment. Since, methane is a potent greenhouse gas, to reduce the activity and number of methane producing Archaea, it is desirable to have knowledge about the community structure of methanogens and their feed conversion energy mechanism. In order to control various ruminal disorders the insight into microbial ecology will help to develop nutrition and feed management strategies and also to develop better prospects of altering rumen function to mitigate methane generation while still optimizing digestibility and microbial function. This can be particularly useful for the farmer community who can benefit environment in methane mitigation from livestock at the same time increasing animal efficiency. Reductive acetogenesis is performed by acetogenic bacteria that thrive in non-ruminants and can sometimes replace methanogenesis. A comparative account of dominant methanogens in the ruminants all over the world is depicted in \nFigure 2\n.
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Figure 2.
Methanogenic sequences identified in ruminants around the world.
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The significance of exploring the archaeal diversity lies in its great potential to identify the genes encoding plant degrading enzymes, thus contributing to an increase in understanding of the mechanisms mediating digestion in ruminants. Moreover, the functional analysis of these genes might uncover strategies for improving feed and fiber digestion in the rumen that could further be applied to manipulate pathways associated with bioreactor processes for biofuels production and to formulate feed with dietary additives that help in reducing methane emissions. A taxonomic frame of methanogens should be developed that would help elucidate the diversity, identification and classification of major rumen archaeal population. Data from antibiotic resistance genes and RATC (resistance to antibiotics and toxic compounds) can be also used to produce antibiotic resistance gene profiles to help in understanding of the microbial community ecology in every environment.
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One can exploit enzymes from extremophile Archaea that can endure high temperatures and organic solvents. Acidophiles are used in coal mining to recover metallic minerals and to reduce sulfur levels. Alkaliphiles are used in paper making and spilled oil recovery, besides being used as a common ingredient in dish washing detergent and laundry soap. Thermus aquaticus an extremophile that endures high temperature produces an enzyme called Taq polymerase that has transformed molecular biology all over the world by aiding in quick DNA replication during polymerase chain reaction (PCR). The extremophiles are immensely used in medical and food microbiology, industrial fermentations to produce acetone, butanol, etc. The understanding of microbial diversity in extreme habitats like wetlands can propose research strategies and priorities to integrate understanding of plant-microbial interactions. Further, studies should provide the break through to link distribution and distinctiveness of various gastrointestinal microbes in their natural environment and to discover their genetic potential for livestock wellbeing and industrial progress by making a significant contribution in understanding ruminant nutrition. Research in microbial genomics will provide the opportunity to make sure that this knowledge is used to enhance ruminant production through an improved understanding of microbial function and ecology.
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\n\n',keywords:"Archaea, gut, methanogens, microbiome, Methanobrevibacter spp., rumen",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/65778.pdf",chapterXML:"https://mts.intechopen.com/source/xml/65778.xml",downloadPdfUrl:"/chapter/pdf-download/65778",previewPdfUrl:"/chapter/pdf-preview/65778",totalDownloads:856,totalViews:0,totalCrossrefCites:0,dateSubmitted:"November 3rd 2018",dateReviewed:"December 1st 2018",datePrePublished:"February 21st 2019",datePublished:"February 24th 2021",dateFinished:"February 21st 2019",readingETA:"0",abstract:"To elucidate the microbial dynamics inside rumen of animals of livestock importance and to provide a better ration to them in order to control various metabolic disorders, a better understanding of the rumen microbial ecology is pivotal. The fundamental knowledge of methanogenic population inside gut environment and ruminal fermentation is of considerable importance as it has a significant impact on the various metabolic activities of the animal. The major methanogens isolated and characterized from ruminants like cattle, sheep, steers, goats, reindeers are from the order Methanobacteriales, Methanomicrobiales, Methanococcales, Methanosarcinales and Methanomassiliicoccales. The chapter deals with present knowledge available regarding the methanogenic diversity present in the gastro-intestinal tract of ruminants all over the world primarily through constructing 16S rRNA gene clone libraries and tries to uncover the new genera in ruminant’s microbiome and their adaptations in extreme environment. To get a better idea regarding the composition of methanogen community, further studies are required in relation to the effect of diet and animal species to the rumen methanogens.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/65778",risUrl:"/chapter/ris/65778",signatures:"Farah Naz Faridi and Saba Khan",book:{id:"8415",type:"book",title:"Extremophilic Microbes and Metabolites",subtitle:"Diversity, Bioprospecting and Biotechnological Applications",fullTitle:"Extremophilic Microbes and Metabolites - Diversity, Bioprospecting and Biotechnological Applications",slug:"extremophilic-microbes-and-metabolites-diversity-bioprospecting-and-biotechnological-applications",publishedDate:"February 24th 2021",bookSignature:"Afef Najjari, Ameur Cherif, Haïtham Sghaier and Hadda Imene Ouzari",coverURL:"https://cdn.intechopen.com/books/images_new/8415.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83969-039-6",printIsbn:"978-1-83969-038-9",pdfIsbn:"978-1-83969-040-2",isAvailableForWebshopOrdering:!0,editors:[{id:"196823",title:"Dr.",name:"Afef",middleName:null,surname:"Najjari",slug:"afef-najjari",fullName:"Afef Najjari"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"263998",title:"Dr.",name:"Farah",middleName:null,surname:"Faridi",fullName:"Farah Faridi",slug:"farah-faridi",email:"farah.faridi@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"280475",title:"Dr.",name:"Saba",middleName:null,surname:"Khan",fullName:"Saba Khan",slug:"saba-khan",email:"drsabakhan1808@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Major rumen microbes",level:"1"},{id:"sec_3",title:"3. Methane production in ruminants and its contribution to greenhouse gases",level:"1"},{id:"sec_4",title:"4. Methanogenic archaeal population in gastro-intestinal tract of ruminants",level:"1"},{id:"sec_5",title:"5. Effect of diet on diversity of rumen methanogens",level:"1"},{id:"sec_6",title:"6. Methanogen diversity inside rumen and/feces under similar conditions of diet",level:"1"},{id:"sec_7",title:"7. Methanogenic archaeal population in pseudo ruminants like camelids",level:"1"},{id:"sec_8",title:"8. Biotechnological applications of extremophiles",level:"1"}],chapterReferences:[{id:"B1",body:'\nTakai K, Horikoshi K. Genetic diversity of Archaea in deep-sea hydrothermal vent environments. Genetics. 1999;152(4):1285-1297\n'},{id:"B2",body:'\nFlorin TH, Zhu G, Kirk KM, Martin MG. Shared and unique environmental factors determine the ecology of methanogens in humans and rats. The American Journal of Gastroenterology. 2000;95(10):2872-2879\n'},{id:"B3",body:'\nHungate RE. The Rumen and its Microbes. New York: Academic Press Inc; 2006\n'},{id:"B4",body:'\nBryant MP. Bacterial species of the rumen. Bacteriological Reviews. 1959;23(3):125-153\n'},{id:"B5",body:'\nWoese CR, Kandler O, Wheelis ML. Towards a natural system of organisms: Proposal for the domains Archaea, Bacteria, and Eucarya. Proceedings of the National Academy of Sciences of the United States of America. 1990;87(12):4576-4579\n'},{id:"B6",body:'\nHobson PN, Stewart CS. The Rumen Microbial Ecosystem. London: Chapmann & Hall; 1997\n'},{id:"B7",body:'\nLiu Y, Whitmann WB. Metabolic, phylogenetic, and ecological diversity of the methanogenic Archaea. Annals of the New York Academy of Sciences. 2008;1125:171-189\n'},{id:"B8",body:'\nSakai S, Imachi H, Hanada S, Ohashi A, Harada H, Kamagata Y. Methanocella paludicola gen. nov., sp. nov., a methane-producing archaeon, the first isolate of the lineage ‘Rice Cluster I’, and proposal of the new archaeal order Methanocellales ord. nov. International Journal of Systematic and Evolutionary Microbiology. 2008;58(4):929-936\n'},{id:"B9",body:'\nPaul K, Nonoh JO, Mikulski L, Brune A. “Methanoplasmatales,” Thermoplasmatales-related Archaea in termite guts and other environments, are the seventh order of methanogens. Applied and Environmental Microbiology. 2012;78(23):8245-8253\n'},{id:"B10",body:'\nJohnson KA, Johnson DE. Methane emissions from cattle. Journal of Animal Science. 1995;73(8):2483-2492\n'},{id:"B11",body:'\nKumar S, Puniya AK, Puniya M, Dagar SS, Sirohi SK, Singh K, et al. Factors affecting rumen methanogens and methane mitigation strategies. World Journal of Microbiology and Biotechnology. 2009;25(9):1557-1566\n'},{id:"B12",body:'\nBroucek J. Production of methane emissions from ruminant husbandry: A review. Journal of Environmental Protection. 2014;5:1482-1493\n'},{id:"B13",body:'\nFAO. FAOSTAT Database Collections. Food and Agriculture Organization of the United Nations; 2014. Available from: http://faostat.fao.org/\n\n'},{id:"B14",body:'\nMoss AR, Jouany JP, Newbold J. Methane production by ruminants: Its contribution to global warming. Annales de Zootechnie. 2000;49:231-253\n'},{id:"B15",body:'\nHungate RE. Symposium: Selected topics in microbial ecology. Microbial ecology of the rumen. Bacteriological Reviews. 1960;24(4):353-364\n'},{id:"B16",body:'\nKrause DO, Russell JB. An rRNA approach for assessing the role of obligate amino acid-fermenting bacteria in ruminal amino acid deamination. Applied and Environmental Microbiology. 1996;62(3):815-821\n'},{id:"B17",body:'\nLin C, Raskin L, Stahl DA. Microbial community structure in gastro intestinal tracts of domestic animals: Comparative analyses using rRNA targeted oligonucleotide probes. FEMS Microbiology Ecology. 1997;22:281-294\n'},{id:"B18",body:'\nYanagita K, Kamagata Y, Kawaharasaki M, Suzuki T, Nakamura Y, Minato H. Phylogenetic analysis of methanogens in sheep rumen ecosystem and detection of Methanomicrobium mobile by flourescence in situ hybridization. Bioscience, Biotechnology, and Biochemistry. 2000;64(8):1737-1742\n'},{id:"B19",body:'\nTajima K, Nagamine T, Matsui H, Nakamura M, Aminov RI. Phylogenetic analysis of archaeal 16S rRNA libraries from the rumen suggests the existence of a novel group of Archaea not associated with known methanogens. FEMS Microbiology Letters. 2001;200(1):67-72\n'},{id:"B20",body:'\nWhitford MF, Teather RM, Forster RJ. Phylogenetic analysis of methanogens from the bovine rumen. BMC Microbiology. 2001;1(1):5\n'},{id:"B21",body:'\nTatsuoka N, Mohammed N, Mitsumori M, Hara K, Kurihara M, Itabashi H. Phylogenetic analysis of methyl coenzyme-M reductase detected from the bovine rumen. Letters in Applied Microbiology. 2004;39(3):257-260\n'},{id:"B22",body:'\nShin EC, Choi BR, Lim WJ, Hong SY, An CL, Cho KM, et al. Phylogenetic analysis of Archaea in three fractions of cow rumen based on the 16S rDNA sequence. Anaerobe. 2004;10(6):313-319\n'},{id:"B23",body:'\nChaudhary PP, Sirohi SK. Dominance of Methanomicrobium phylotype in methanogen population present in Murrah buffaloes (Bubalus bubalis). Letters in Applied Microbiology. 2009;49:274-277\n'},{id:"B24",body:'\nSingh KM, Pandya PR, Parnekar S, Tripathi AK, Ramani U, Koringa PG, et al. Methanogenic diversity studies within the rumen of Surti buffaloes based on methyl coenzyme M reductase A (mcrA) genes point to Methanobacteriales. Polish Journal of Microbiology. 2010;59(3):175-178\n'},{id:"B25",body:'\nKumar S, Dagar SS, Puniya AK. Isolation and characterization of methanogens from rumen of Murrah buffalo. Annales de Microbiologie. 2011;62(1):345-350\n'},{id:"B26",body:'\nWang P, Zhao S, Wang X, Zhang Y, Zheng N, Wang J. Ruminal methanogen community in dairy cows fed agricultural residues of corn stover, rapeseed, and cottonseed meals. Journal of Agricultural and Food Chemistry. 2016;64(27):5439-5445\n'},{id:"B27",body:'\nWright A-DG, Williams AJ, Winder B, Christophersen CT, Rodgers SL, Smith KD. Molecular diversity of rumen methanogens from sheep in Western Australia. Applied and Environmental Microbiology. 2004;70(3):1263-1270\n'},{id:"B28",body:'\nPei CX, Mao SY, Cheng YF, Zhu WY. Diversity, abundance and novel16S rRNA gene sequences of methanogens in rumen liquid, solid and epithelium fractions of Jinnan cattle. Animal. 2010;4(1):20-29\n'},{id:"B29",body:'\nZhou M, Chung YH, Beauchemin KA, Holtshausen L, Oba M, McAllister TA, et al. Relationship between rumen methanogens and methane production in dairy cows fed diets supplemented with a feed enzyme additive. Journal of Applied Microbiology. 2011;111(5):1148-1158\n'},{id:"B30",body:'\nFranzolin R, St-Pierre B, Northwood K. Analysis of rumen methanogen diversity in water buffaloes (Bubalus bubalis) under three different diets. Microbial Ecology. 2012;64(1):131-139\n'},{id:"B31",body:'\nDanielsson R, Schnürer A, Arthurson V, Bertilsson J. Methanogenic population and CH4 production in Swedish dairy cows fed different levels of forage. Applied and Environmental Microbiology. 2012;78(17):6172-6179\n'},{id:"B32",body:'\nWright A-DG, Toovey AF, Pimm C. Molecular identification of methanogenic Archaea from sheep in Queensland, Australia reveal more uncultured novel Archaea. Anaerobe. 2006;12(3):134-139\n'},{id:"B33",body:'\nWright A-DG, Auckland C, Lynn DH. Molecular diversity of methanogens in feedlot cattle from Ontario and Prince Edward Island, Canada. Applied and Environmental Microbiology. 2007;73(13):4206-4210\n'},{id:"B34",body:'\nJannsen PH, Kirs M. Structure of the archaeal community of the rumen. Applied and Environmental Microbiology. 2008;74(12):3619-3625\n'},{id:"B35",body:'\nWright A-DG, Ma X, Obispo NE. Methanobrevibacter phylotypes are the dominant methanogens in sheep from Venezuela. Microbial Ecology. 2008;56(2):390-394\n'},{id:"B36",body:'\nLi ZP, Liu HL, Jin CA, Cui XZ, Jing Y, Yang FH, et al. Differences in the methanogen population exist in Sika deer (Cervus nippon) fed different diets in China. Microbial Ecology. 2013;66(4):879-888\n'},{id:"B37",body:'\nCunha IS, Barreto CC, Costa OYA, Bomfim MA, Castro AP, Kruger RH, et al. Bacteria and Archaea community structure in the rumen microbiome of goats (Capra hircus) from the semiarid region of Brazil. Anaerobe. 2011;17(3):118-124\n'},{id:"B38",body:'\nKing EE, Smith RP, St-Pierre B, A-DG W. Differences in the rumen methanogen populations of lactating Jersey and Holstein dairy cows under the same diet regimen. Applied and Environmental Microbiology. 2011;77(16):5682-5687\n'},{id:"B39",body:'\nJeyanathan J, Kirs M, Ronimus RS, Hoskin SO, Janssen PH. Methanogen community structure in the rumens of farmed sheep, cattle and red deer fed different diets. FEMS Microbiology Ecology. 2011;76(2):311-326\n'},{id:"B40",body:'\nLiu C, Zhu ZP, Liu YF, Guo TJ, Dong HM. Diversity and abundance of the rumen and fecal methanogens in Altay sheep native to Xinjiang and the influence of diversity on methane emissions. Archives of Microbiology. 2012;194:353-361\n'},{id:"B41",body:'\nOzutsumi Y, Tajima K, Takenaka A, Itabashi H. McrA gene and 16S rRNA gene in the phylogenetic analysis of methanogens in the rumen of faunated and unfaunated cattle. Animal Science Journal. 2012;83:727-734\n'},{id:"B42",body:'\nSnelling TJ, Genc B, McKain N, Watson M, Waters SM, Creevey CJ, et al. Diversity and community composition of methanogenic Archaea in the rumen of Scottish upland sheep assessed by different methods. PLoS One. 2012;9(9):1-9\n'},{id:"B43",body:'\nTymensen LD, McAllister TA. Community structure analysis of methanogens associated with rumen protozoa reveals bias in universal archaeal primers. Applied and Environmental Microbiology. 2012;78(11):4051-4056\n'},{id:"B44",body:'\nPoulsen M, Schwab C, Jensen BB, Engberg RM, Spang A, Canibe N, et al. Methylotrophic methanogenic Thermoplasmata implicated in reduced methane emissions from bovine rumen. Nature Communications. 2013;4:1428\n'},{id:"B45",body:'\nSeedorf H, Kittelmann S, Janssen PH. Few highly abundant operational taxonomic units dominate within rumen methanogenic archaeal species in New Zealand sheep and cattle. Applied and Environmental Microbiology. 2015;81(3):986-995\n'},{id:"B46",body:'\nXue D, Chen H, Chen F, He Y, Zhao C, Zhu D, et al. Analysis of the rumen bacteria and methanogenic Archaea of yak (Bos grunniens) steers grazing on the Qinghai-Tibetan plateau. Livestock Science. 2016;188:61-71\n'},{id:"B47",body:'\nHuang XD, Martinez-Fernandez G, Padmanabha J, Long R, Denman SE, McSweeney CS. Methanogen diversity in indigenous and introduced ruminant species on the Tibetan plateau. Archaea. 2016:1-11\n'},{id:"B48",body:'\nSalgado-Flores A, Hagen LH, Ishaq SL, Zamanzadeh M, Wright A-DG, Pope PB, et al. Rumen and cecum microbiomes in reindeer (Rangifer tarandus tarandus) are changed in response to a lichen diet and may affect enteric methane emissions. PLoS One. 2016;11(5):1-22\n'},{id:"B49",body:'\nFranzolin R, A-DG W. Microorganisms in the rumen and reticulum of buffalo (Bubalus bubalis) fed two different feeding systems. BMC Research Notes. 2016;9:243\n'},{id:"B50",body:'\nChaudhary PP, Dagar SS, Sirohi SK. Comparative quantification of major rumen microbial population in Indian cattle and Buffalo fed on wheat straws based diet. Prime Journal Microbiology Research. 2012;2(3):105-108\n'},{id:"B51",body:'\nChaudhary PP, Sirohi SK, Saxena J. Diversity analysis of methanogens in rumen of Bubalus bubalis by 16S riboprinting and sequence analysis. Gene. 2012;493:13-17\n'},{id:"B52",body:'\nSirohi SK, Chaudhary PP, Singh N, Singh D, Puniya AK. The 16S rRNA and mcrA gene based comparative diversity of methanogens in cattle fed on high fibre based diet. Gene. 2013;523:161-166\n'},{id:"B53",body:'\nSingh KM, Tripathi AK, Pandya PR, Parnerkar S, Kothari RK, Joshi CG. Molecular genetic diversity and quantitation of methanogen in Ruminal fluid of Buffalo (Bubalus bubalis) fed ration (wheat straw and concentrate mixture diet). Genetics Research International. 2013;2013:1-8\n'},{id:"B54",body:'\nNathani NM, Patel AK, Dhamannapatil PS, Kothari RK, Singh KM, Joshi CG. Comparative evaluation of rumen metagenome community using qPCR and MG-RAST. AMB Express. 2013;3:55\n'},{id:"B55",body:'\nTurnbull KL, Smith RP, St-Pierre B, Wright A-DG. Molecular diversity of methanogens in fecal samples from Bactrian camels (Camelus bactrianus) at two zoos. Research in Veterinary Science. 2012;93(1):246-249\n'},{id:"B56",body:'\nSt-Pierre B, A-DG W. Molecular analysis of methanogenic Archaea in the forestomach of the alpaca (Vicugna pacos). BMC Microbiology. 2012;12(1)\n'},{id:"B57",body:'\nDande SS, Bhatt VD, Patil NV, Joshi CG. The camel faecal metagenome under different systems of management: Phylogenetic and gene-centric approach. Livestock Science. 2015;178:108-118\n'},{id:"B58",body:'\nFaridi F, Sena DS, Sharma V. Characterization of the methanogenic archaeal community in the C1 compartment of the camel (camelus dromedarius). Journal of Camel Practice and Research. 2017;24(2):157-163\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Farah Naz Faridi",address:"farah.faridi@gmail.com",affiliation:'
Department of Bioscience and Biotechnology, Banasthali Vidyapith, India
Department of Veterinary Pathology, Post Graduate Institute of Veterinary Education and Research, India
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While melanoma is the deadliest form of skin cancer, non-melanoma skin cancers, which include basal cell carcinoma and squamous cell carcinoma, are responsible for significant morbidity in millions of Americans each year. While numerous attempts have been made to reduce skin cancer risk factors related to ultraviolet radiation exposure, skin cancer incidence continues to rise. Improved understanding of the molecular pathways underlying skin cancer pathogenesis has led to the investigation of new approaches to skin cancer prevention. In particular, the search for ultraviolet radiation associated biomarkers of skin cancer has become a rapidly expanding and promising area of research. Advances in genetic sequencing have facilitated the discovery of novel biomarkers, which have the potential to profoundly improve patient care. 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Lopez, Liang Liu and Larisa Geskin",authors:[{id:"214089",title:"B.A.",name:"Adriana",surname:"Lopez",fullName:"Adriana Lopez",slug:"adriana-lopez",email:"atl2134@columbia.edu"},{id:"219947",title:"Dr.",name:"Liang",surname:"Liu",fullName:"Liang Liu",slug:"liang-liu",email:"ll2697@cumc.columbia.edu"},{id:"219948",title:"Dr.",name:"Larisa",surname:"Geskin",fullName:"Larisa Geskin",slug:"larisa-geskin",email:"ljg2145@cumc.columbia.edu"}],book:{id:"6078",title:"Human Skin Cancers",slug:"human-skin-cancers-pathways-mechanisms-targets-and-treatments",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"46010",title:"Prof.",name:"Gabriela",surname:"Negroiu",slug:"gabriela-negroiu",fullName:"Gabriela Negroiu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"206108",title:"Dr.",name:"Marcela",surname:"Valko-Rokytovská",slug:"marcela-valko-rokytovska",fullName:"Marcela Valko-Rokytovská",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Veterinary Medicine in Košice",institutionURL:null,country:{name:"Slovakia"}}},{id:"209093",title:"B.A.",name:"Yixuan James",surname:"Zheng",slug:"yixuan-james-zheng",fullName:"Yixuan James Zheng",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"209094",title:"Dr.",name:"Suzana",surname:"Ortiz",slug:"suzana-ortiz",fullName:"Suzana Ortiz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"214089",title:"B.A.",name:"Adriana",surname:"Lopez",slug:"adriana-lopez",fullName:"Adriana Lopez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Columbia University",institutionURL:null,country:{name:"United States of America"}}},{id:"216042",title:"Dr.",name:"Jana",surname:"Šimková",slug:"jana-simkova",fullName:"Jana Šimková",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"216043",title:"Dr.",name:"Mária",surname:"Milkovičová",slug:"maria-milkovicova",fullName:"Mária Milkovičová",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"216044",title:"Prof.",name:"Zuzana",surname:"Kostecká",slug:"zuzana-kostecka",fullName:"Zuzana Kostecká",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"217160",title:"Dr.",name:"Adina",surname:"Milac",slug:"adina-milac",fullName:"Adina Milac",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Institute of Biochemistry",institutionURL:null,country:{name:"Romania"}}},{id:"217602",title:"Dr.",name:"Ricardo",surname:"Traspas",slug:"ricardo-traspas",fullName:"Ricardo Traspas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"open-access-statement",title:"Open Access Statement",intro:"
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Pal is Professor of Physics at Mahindra École\nCentrale Hyderabad India since July 1st 2014 after retirement\nas Professor of Physics from IIT Delhi; Ph.D.’1975 from IIT\nDelhi; Fellow of OSA and SPIE; Senior Member IEEE;\nHonorary Foreign Member Royal Norwegian Society for\nScience and Arts; Member OSA Board of Directors (2009-\n11); Distinguished Lecturer IEEE Photonics Society (2005-\n07).",institutionString:null,institution:{name:"Indian Institute of Technology Delhi",country:{name:"India"}}},{id:"69653",title:"Dr.",name:"Chusak",middleName:null,surname:"Limsakul",slug:"chusak-limsakul",fullName:"Chusak Limsakul",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Prince of Songkla University",country:{name:"Thailand"}}},{id:"23804",title:"Dr.",name:"Hamzah",middleName:null,surname:"Arof",slug:"hamzah-arof",fullName:"Hamzah Arof",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/23804/images/5492_n.jpg",biography:"Hamzah Arof received his BSc from Michigan State University, and PhD from the University of Wales. 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They cure soon after mixing the two components together. Almost all room temperature cure epoxy adhesives are supplied in two-component package. One-component epoxy adhesives are prepared and supplied by mixing all formulated components in advance including epoxy resin and curing agent. One-component epoxy adhesives usually need cure at elevated temperature and store at low temperature in a refrigerator or even freezer. Epoxy adhesives have been widely used as typical reactive adhesives for various applications ranging from general industry, construction, electronics assembly, automobile production to aerospace market. Typical room temperature cure epoxy adhesives, thermal cure epoxy adhesives and UV cure epoxy adhesives are introduced in detail.",book:{id:"7679",slug:"adhesives-and-adhesive-joints-in-industry-applications",title:"Adhesives and Adhesive Joints in Industry Applications",fullTitle:"Adhesives and Adhesive Joints in Industry Applications"},signatures:"Chunfu Chen, Bin Li, Masao Kanari and Daoqiang Lu",authors:[{id:"234454",title:"Dr.",name:"Chunfu",middleName:null,surname:"Chen",slug:"chunfu-chen",fullName:"Chunfu Chen"}]},{id:"51522",doi:"10.5772/64247",title:"Friction and Wear in Automotive Journal Bearings Operating in Today’s Severe Conditions",slug:"friction-and-wear-in-automotive-journal-bearings-operating-in-today-s-severe-conditions",totalDownloads:2877,totalCrossrefCites:3,totalDimensionsCites:12,abstract:"A current trend in the transport sector seeks to increase the vehicle efficiency and to cut fuel consumption which leads to new technologies and advancements in modern and future combustion engines. Some of these technical progresses lead to highly stressed engine parts and new challenges arise, particularly for journal bearings. The increasing thermal and mechanical load caused by downsized and turbocharged engines, friction reduction by employing low-viscosity lubricants and other emission reduction measures—for utilizing stop-start systems—put additional stress on the crankshaft journal bearings. This contribution focuses on highly stressed journal bearings which operate in the boundary, mixed and hydrodynamic lubrication regime. Therefore, measurements on a journal bearing test-rig are performed which allow an extensive verification of the numerical investigation. For the numerical analysis of friction and wear, a mixed elasto-hydrodynamic simulation approach is developed, which considers the elastic deformation of the contacting components, the complex rheological behaviour of the lubricant and metal-metal contact if the lubricant is unable to separate the contacting surfaces. Both the rheological data and the surface roughness parameters are obtained from measurements. The current challenges are studied in four application-oriented examples and the influencing parameters on a reliable friction and wear prediction are explored.",book:{id:"5271",slug:"advances-in-tribology",title:"Advances in Tribology",fullTitle:"Advances in Tribology"},signatures:"David E. 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While the use of phosphorus compounds has been extensive, a detailed knowledge of how they work has been a much more recent development. In this chapter, the use of phosphate esters, thiophosphate esters, metal thiophosphates and phosphorus‐containing ionic liquids as antiwear or extreme pressure additives is discussed. The primary emphasis will be on how they form a protective film, which is both durable and reduces friction. The first part of the chapter discusses the use of alkyl phosphates, triaryl phosphates and metal‐containing thiophosphate esters with primarily iron‐ and steel‐based bearing materials. The second part of the chapter examines phosphorus‐containing ionic liquids and the challenges posed by new bearing materials with different surface chemistries.",book:{id:"5271",slug:"advances-in-tribology",title:"Advances in Tribology",fullTitle:"Advances in Tribology"},signatures:"David W. 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Tribocorrosion test is needs to special arrangement of cell to be predicted which also has been mentioned in this chapter.",book:{id:"5271",slug:"advances-in-tribology",title:"Advances in Tribology",fullTitle:"Advances in Tribology"},signatures:"Rana Afif Majed Anaee and Majid Hameed Abdulmajeed",authors:[{id:"181900",title:"Dr.",name:"Rana",middleName:"Afif",surname:"Anaee",slug:"rana-anaee",fullName:"Rana Anaee"},{id:"190735",title:"M.Sc.",name:"Majid",middleName:"Hameed",surname:"Abdulmajeed",slug:"majid-abdulmajeed",fullName:"Majid Abdulmajeed"}]},{id:"51347",doi:"10.5772/63533",title:"Modelling Cavitation in (Elasto)Hydrodynamic Lubrication",slug:"modelling-cavitation-in-elasto-hydrodynamic-lubrication",totalDownloads:1650,totalCrossrefCites:3,totalDimensionsCites:7,abstract:"In this chapter we will present a derivation of a mathematical model describing how cavitation influences the pressure distribution in a thin lubricant film between two moving surfaces. The main idea in the derivation is to first describe the influence of cavitation on the mass flow and thereafter using a conservation law for the mass. This leads to a nonlinear system with two complementary variables: one is the pressure distribution and the other is related to the density, i.e. a nonlinear complementarity problem (NLCP). The proposed approach is used to derive a mass conserving cavitation model considering that density, viscosity and film thickness of the lubricant depend on the pressure. To demonstrate the applicability and evaluate the proposed model and the suggested numerical implementation, a few model problems are analysed and presented.",book:{id:"5271",slug:"advances-in-tribology",title:"Advances in Tribology",fullTitle:"Advances in Tribology"},signatures:"Andreas Almqvist and Peter Wall",authors:[{id:"181745",title:"Dr.",name:"Andreas",middleName:null,surname:"Almqvist",slug:"andreas-almqvist",fullName:"Andreas Almqvist"},{id:"185675",title:"Prof.",name:"Peter",middleName:null,surname:"Wall",slug:"peter-wall",fullName:"Peter Wall"}]}],mostDownloadedChaptersLast30Days:[{id:"69687",title:"Modeling of Creep Deformation and Creep Fracture",slug:"modeling-of-creep-deformation-and-creep-fracture",totalDownloads:1e3,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"This chapter reports the recent progresses in (1) the development of a modified hyperbolic sine law able to depict the minimum creep strain rate over a wider range of stress levels; (2) the development of the creep fracture criterion and model based on the cavity area fraction along grain boundary calibrated with the most representative and comprehensive cavitation data obtained from X-ray synchrotron investigation; and (3) the development of mesoscopic composite approach modeling of creep deformation and creep damage. The first progress facilitates to overcome the difficulty in creep deformation modeling caused by stress breakdown phenomenon; the second progress is of a really scientifically sound and fundamental new approach, first in the world; the third progress provides the concept and tool, at the appropriate size scale, for the modeling of the creep deformation and creep fracture. They all contribute to the specific knowledge and new methodology to the topic area. Furthermore, it is expected that cavitation fracture modeling methodology reported here will find use in the analysis and modeling of other types of failure such as ductile and fatigue failure. This chapter presents an excellent example of interdisciplinary collaborative research and it advocates further such collaboration in its conclusion.",book:{id:"9265",slug:"strength-of-materials",title:"Strength of Materials",fullTitle:"Strength of Materials"},signatures:"Qiang Xu and Zhongyu Lu",authors:[{id:"308353",title:"Dr.",name:"Qiang",middleName:null,surname:"Xu",slug:"qiang-xu",fullName:"Qiang Xu"},{id:"319445",title:"Dr.",name:"Zhongyu",middleName:null,surname:"Lu",slug:"zhongyu-lu",fullName:"Zhongyu Lu"}]},{id:"66810",title:"Free Vibration of Axially Functionally Graded Beam",slug:"free-vibration-of-axially-functionally-graded-beam",totalDownloads:1160,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Axially functionally graded (AFG) beam is a special kind of nonhomogeneous functionally gradient material structure, whose material properties vary continuously along the axial direction of the beam by a given distribution form. There are several numerical methods that have been used to analyze the vibration characteristics of AFG beams, but it is difficult to obtain precise solutions for AFG beams because of the variable coefficients of the governing equation. In this topic, the free vibration of AFG beam using analytical method based on the perturbation theory and Meijer G-Function are studied, respectively. First, a detailed review of the existing literatures is summarized. Then, based on the governing equation of the AFG Euler-Bernoulli beam, the detailed analytic equations are derived on basis of the perturbation theory and Meijer G-function, where the nature frequencies are demonstrated. Subsequently, the numerical results are calculated and compared, meanwhile, the analytical results are also confirmed by finite element method and the published references. The results show that the proposed two analytical methods are simple and efficient and can be used to conveniently analyze free vibration of AFG beam.",book:{id:"8844",slug:"mechanics-of-functionally-graded-materials-and-structures",title:"Mechanics of Functionally Graded Materials and Structures",fullTitle:"Mechanics of Functionally Graded Materials and Structures"},signatures:"Dongxing Cao, Bin Wang, Wenhua Hu and Yanhui Gao",authors:[{id:"283678",title:"Prof.",name:"Dongxing",middleName:null,surname:"Cao",slug:"dongxing-cao",fullName:"Dongxing Cao"},{id:"295692",title:"Mr.",name:"Bin",middleName:null,surname:"Wang",slug:"bin-wang",fullName:"Bin Wang"},{id:"295693",title:"Dr.",name:"Wenhua",middleName:null,surname:"Hu",slug:"wenhua-hu",fullName:"Wenhua Hu"},{id:"295694",title:"Mr.",name:"Yanhui",middleName:null,surname:"Gao",slug:"yanhui-gao",fullName:"Yanhui Gao"}]},{id:"51522",title:"Friction and Wear in Automotive Journal Bearings Operating in Today’s Severe Conditions",slug:"friction-and-wear-in-automotive-journal-bearings-operating-in-today-s-severe-conditions",totalDownloads:2873,totalCrossrefCites:3,totalDimensionsCites:12,abstract:"A current trend in the transport sector seeks to increase the vehicle efficiency and to cut fuel consumption which leads to new technologies and advancements in modern and future combustion engines. Some of these technical progresses lead to highly stressed engine parts and new challenges arise, particularly for journal bearings. The increasing thermal and mechanical load caused by downsized and turbocharged engines, friction reduction by employing low-viscosity lubricants and other emission reduction measures—for utilizing stop-start systems—put additional stress on the crankshaft journal bearings. This contribution focuses on highly stressed journal bearings which operate in the boundary, mixed and hydrodynamic lubrication regime. Therefore, measurements on a journal bearing test-rig are performed which allow an extensive verification of the numerical investigation. For the numerical analysis of friction and wear, a mixed elasto-hydrodynamic simulation approach is developed, which considers the elastic deformation of the contacting components, the complex rheological behaviour of the lubricant and metal-metal contact if the lubricant is unable to separate the contacting surfaces. Both the rheological data and the surface roughness parameters are obtained from measurements. The current challenges are studied in four application-oriented examples and the influencing parameters on a reliable friction and wear prediction are explored.",book:{id:"5271",slug:"advances-in-tribology",title:"Advances in Tribology",fullTitle:"Advances in Tribology"},signatures:"David E. Sander, Hannes Allmaier and Hans-Herwig Priebsch",authors:[{id:"151052",title:"Dr.",name:"Hannes",middleName:null,surname:"Allmaier",slug:"hannes-allmaier",fullName:"Hannes Allmaier"},{id:"151317",title:"Mr.",name:"David",middleName:"E.",surname:"Sander",slug:"david-sander",fullName:"David Sander"},{id:"188490",title:"Prof.",name:"Hans-Herwig",middleName:null,surname:"Priebsch",slug:"hans-herwig-priebsch",fullName:"Hans-Herwig Priebsch"}]},{id:"70512",title:"Residual Stress Modeling and Deformation Measurement in Laser Metal Deposition Process",slug:"residual-stress-modeling-and-deformation-measurement-in-laser-metal-deposition-process",totalDownloads:844,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Direct metal deposition (DMD) has become very popular within the space of rapid manufacturing and repair. Its capability of producing fully dense metal parts with complex internal geometries, which could not be easily achieved by traditional manufacturing approaches, has been well demonstrated. However, the DMD process usually comes with high thermal gradients and high heating and cooling rates, leading to residual stresses and the associated deformation, which can have negative effect on product integrity. This paper studies the features of thermal stress and deformation involved in the DMD process by constructing a 3-D, sequentially coupled, thermomechanical, finite element model to predict both the thermal and mechanical behaviors of the DMD process of Stainless Steel 304 (SS 304). A set of experiments were then conducted to validate deformation using a laser displacement sensor. Comparisons between the simulated and experimental results show good agreement. This model can be used to predict the mechanical behavior of products fabricated by the DMD process and to help with the optimization of design and manufacturing parameters.",book:{id:"8457",slug:"new-challenges-in-residual-stress-measurements-and-evaluation",title:"New Challenges in Residual Stress Measurements and Evaluation",fullTitle:"New Challenges in Residual Stress Measurements and Evaluation"},signatures:"Heng Liu and Frank Liou",authors:[{id:"101869",title:"Prof.",name:"Frank",middleName:null,surname:"Liou",slug:"frank-liou",fullName:"Frank Liou"},{id:"292019",title:"Mr.",name:"Heng",middleName:null,surname:"Liu",slug:"heng-liu",fullName:"Heng Liu"}]},{id:"67088",title:"Epoxy Adhesives",slug:"epoxy-adhesives",totalDownloads:1261,totalCrossrefCites:0,totalDimensionsCites:14,abstract:"Epoxy adhesives are primarily composed of epoxy resin and curing agent. Epoxy adhesives are supplied in both one-component package and two-component package depending on curing agent used and curing method applied. Two-component epoxy adhesives are prepared by packing epoxy composition and curing agent composition separately. They cure soon after mixing the two components together. Almost all room temperature cure epoxy adhesives are supplied in two-component package. One-component epoxy adhesives are prepared and supplied by mixing all formulated components in advance including epoxy resin and curing agent. One-component epoxy adhesives usually need cure at elevated temperature and store at low temperature in a refrigerator or even freezer. Epoxy adhesives have been widely used as typical reactive adhesives for various applications ranging from general industry, construction, electronics assembly, automobile production to aerospace market. Typical room temperature cure epoxy adhesives, thermal cure epoxy adhesives and UV cure epoxy adhesives are introduced in detail.",book:{id:"7679",slug:"adhesives-and-adhesive-joints-in-industry-applications",title:"Adhesives and Adhesive Joints in Industry Applications",fullTitle:"Adhesives and Adhesive Joints in Industry Applications"},signatures:"Chunfu Chen, Bin Li, Masao Kanari and Daoqiang Lu",authors:[{id:"234454",title:"Dr.",name:"Chunfu",middleName:null,surname:"Chen",slug:"chunfu-chen",fullName:"Chunfu Chen"}]}],onlineFirstChaptersFilter:{topicId:"817",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:319,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:16,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:null,scope:"
\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
\r\n
\r\n\t
\r\n
\r\n\tThis Series focuses on covering research and applied research involving the five Ps through the following topics:
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\r\n\t1. Sustainable Economy and Fair Society that relates to SDG 1 on No Poverty, SDG 2 on Zero Hunger, SDG 8 on Decent Work and Economic Growth, SDG 10 on Reduced Inequalities, SDG 12 on Responsible Consumption and Production, and SDG 17 Partnership for the Goals
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\r\n\t2. Health and Wellbeing focusing on SDG 3 on Good Health and Wellbeing and SDG 6 on Clean Water and Sanitation
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\r\n\t
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\r\n\t3. Inclusivity and Social Equality involving SDG 4 on Quality Education, SDG 5 on Gender Equality, and SDG 16 on Peace, Justice and Strong Institutions
\r\n
\r\n\t
\r\n
\r\n\t4. Climate Change and Environmental Sustainability comprising SDG 13 on Climate Action, SDG 14 on Life Below Water, and SDG 15 on Life on Land
\r\n
\r\n\t
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\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
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\r\n\tThe series also seeks to support the use of cross cutting SDGs, as many of the goals listed above, targets and indicators are all interconnected to impact our lives and the decisions we make on a daily basis, making them impossible to tie to a single topic.
",coverUrl:"https://cdn.intechopen.com/series/covers/24.jpg",latestPublicationDate:"July 5th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:0,editor:{id:"262440",title:"Prof.",name:"Usha",middleName:null,surname:"Iyer-Raniga",slug:"usha-iyer-raniga",fullName:"Usha Iyer-Raniga",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRYSXQA4/Profile_Picture_2022-02-28T13:55:36.jpeg",biography:"Usha Iyer-Raniga is a professor in the School of Property and Construction Management at RMIT University. Usha co-leads the One Planet Network’s Sustainable Buildings and Construction Programme (SBC), a United Nations 10 Year Framework of Programmes on Sustainable Consumption and Production (UN 10FYP SCP) aligned with Sustainable Development Goal 12. The work also directly impacts SDG 11 on Sustainable Cities and Communities. She completed her undergraduate degree as an architect before obtaining her Masters degree from Canada and her Doctorate in Australia. Usha has been a keynote speaker as well as an invited speaker at national and international conferences, seminars and workshops. Her teaching experience includes teaching in Asian countries. She has advised Austrade, APEC, national, state and local governments. She serves as a reviewer and a member of the scientific committee for national and international refereed journals and refereed conferences. She is on the editorial board for refereed journals and has worked on Special Issues. Usha has served and continues to serve on the Boards of several not-for-profit organisations and she has also served as panel judge for a number of awards including the Premiers Sustainability Award in Victoria and the International Green Gown Awards. Usha has published over 100 publications, including research and consulting reports. Her publications cover a wide range of scientific and technical research publications that include edited books, book chapters, refereed journals, refereed conference papers and reports for local, state and federal government clients. She has also produced podcasts for various organisations and participated in media interviews. She has received state, national and international funding worth over USD $25 million. Usha has been awarded the Quarterly Franklin Membership by London Journals Press (UK). Her biography has been included in the Marquis Who's Who in the World® 2018, 2016 (33rd Edition), along with approximately 55,000 of the most accomplished men and women from around the world, including luminaries as U.N. Secretary-General Ban Ki-moon. In 2017, Usha was awarded the Marquis Who’s Who Lifetime Achiever Award.",institutionString:null,institution:{name:"RMIT University",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:11,paginationItems:[{id:"91",title:"Sustainable Economy and Fair Society",coverUrl:"https://cdn.intechopen.com/series_topics/covers/91.jpg",editor:{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo",profilePictureURL:"https://mts.intechopen.com/storage/users/181603/images/system/181603.jpg",biography:"Antonella Petrillo is a Professor at the Department of Engineering of the University of Naples “Parthenope”, Italy. She received her Ph.D. in Mechanical Engineering from the University of Cassino. Her research interests include multi-criteria decision analysis, industrial plant, logistics, manufacturing and safety. She serves as an Associate Editor for the International Journal of the Analytic Hierarchy Process. She is a member of AHP Academy and a member of several editorial boards. She has over 160 Scientific Publications in International Journals and Conferences and she is the author of 5 books on Innovation and Decision Making in Industrial Applications and Engineering.",institutionString:null,institution:{name:"Parthenope University of Naples",institutionURL:null,country:{name:"Italy"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"179628",title:"Prof.",name:"Dima",middleName:null,surname:"Jamali",slug:"dima-jamali",fullName:"Dima Jamali",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSAIlQAO/Profile_Picture_2022-03-07T08:52:23.jpg",institutionString:null,institution:{name:"University of Sharjah",institutionURL:null,country:{name:"United Arab Emirates"}}},{id:"170206",title:"Prof.",name:"Dr. Orhan",middleName:null,surname:"Özçatalbaş",slug:"dr.-orhan-ozcatalbas",fullName:"Dr. Orhan Özçatalbaş",profilePictureURL:"https://mts.intechopen.com/storage/users/170206/images/system/170206.png",institutionString:null,institution:{name:"Akdeniz University",institutionURL:null,country:{name:"Turkey"}}},{id:"250347",title:"Associate Prof.",name:"Isaac",middleName:null,surname:"Oluwatayo",slug:"isaac-oluwatayo",fullName:"Isaac Oluwatayo",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRVIVQA4/Profile_Picture_2022-03-17T13:25:32.jpg",institutionString:null,institution:{name:"University of Venda",institutionURL:null,country:{name:"South Africa"}}},{id:"141386",title:"Prof.",name:"Jesús",middleName:null,surname:"López-Rodríguez",slug:"jesus-lopez-rodriguez",fullName:"Jesús López-Rodríguez",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRBNIQA4/Profile_Picture_2022-03-21T08:24:16.jpg",institutionString:null,institution:{name:"University of A Coruña",institutionURL:null,country:{name:"Spain"}}},{id:"208657",title:"Dr.",name:"Mara",middleName:null,surname:"Del Baldo",slug:"mara-del-baldo",fullName:"Mara Del Baldo",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRLMUQA4/Profile_Picture_2022-05-18T08:19:24.png",institutionString:"University of Urbino Carlo Bo",institution:null}]},{id:"92",title:"Health and Wellbeing",coverUrl:"https://cdn.intechopen.com/series_topics/covers/92.jpg",editor:{id:"348225",title:"Prof.",name:"Ann",middleName:null,surname:"Hemingway",slug:"ann-hemingway",fullName:"Ann Hemingway",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035LZFoQAO/Profile_Picture_2022-04-11T14:55:40.jpg",biography:"Professor Hemingway is a public health researcher, Bournemouth University, undertaking international and UK research focused on reducing inequalities in health outcomes for marginalised and excluded populations and more recently focused on equine assisted interventions.",institutionString:null,institution:{name:"Bournemouth University",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"169536",title:"Dr.",name:"David",middleName:null,surname:"Claborn",slug:"david-claborn",fullName:"David Claborn",profilePictureURL:"https://mts.intechopen.com/storage/users/169536/images/system/169536.jpeg",institutionString:null,institution:{name:"Missouri State University",institutionURL:null,country:{name:"United States of America"}}},{id:"248594",title:"Ph.D.",name:"Jasneth",middleName:null,surname:"Mullings",slug:"jasneth-mullings",fullName:"Jasneth Mullings",profilePictureURL:"https://mts.intechopen.com/storage/users/248594/images/system/248594.jpeg",institutionString:"The University Of The West Indies - Mona Campus, Jamaica",institution:null},{id:"331299",title:"Prof.",name:"Pei-Shan",middleName:null,surname:"Liao",slug:"pei-shan-liao",fullName:"Pei-Shan Liao",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000032Fh2FQAS/Profile_Picture_2022-03-18T09:39:41.jpg",institutionString:"Research Center for Humanities and Social Sciences, Academia Sinica, Taiwan",institution:null}]},{id:"93",title:"Inclusivity and Social Equity",coverUrl:"https://cdn.intechopen.com/series_topics/covers/93.jpg",editor:{id:"210060",title:"Prof. Dr.",name:"Ebba",middleName:null,surname:"Ossiannilsson",slug:"ebba-ossiannilsson",fullName:"Ebba Ossiannilsson",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6LkBQAU/Profile_Picture_2022-02-28T13:31:48.png",biography:"Professor Dr. Ebba Ossiannilsson is an independent researcher, expert, consultant, quality auditor and influencer in the fields of open, flexible online and distance learning (OFDL) and the 'new normal'. Her focus is on quality, innovation, leadership, and personalised learning. She works primarily at the strategic and policy levels, both nationally and internationally, and with key international organisations. She is committed to promoting and improving OFDL in the context of SDG4 and the future of education. Ossiannilsson has more than 20 years of experience in her current field, but more than 40 years in the education sector. She works as a reviewer and expert for the European Commission and collaborates with the Joint Research Centre for Quality in Open Education. Ossiannilsson also collaborates with ITCILO and ICoBC (International Council on Badges and Credentials). She is a member of the ICDE Board of Directors and has previously served on the boards of EDEN and EUCEN. Ossiannilsson is a quality expert and reviewer for ICDE, EDEN and the EADTU. She chairs the ICDE OER Advocacy Committee and is a member of the ICDE Quality Network. She is regularly invited as a keynote speaker at conferences. She is a guest editor for several special issues and a member of the editorial board of several scientific journals. She has published more than 200 articles and is currently working on book projects in the field of OFDL. Ossiannilsson is a visiting professor at several international universities and was recently appointed Professor and Research Fellow at Victoria University of Wellington, NZ. Ossiannilsson has been awarded the following fellowships: EDEN Fellows, EDEN Council of Fellows, and Open Education Europe. She is a ICDE OER Ambassador, Open Education Europe Ambassador, GIZ Ambassador for Quality in Digital Learning, and part of the Globe-Community of Digital Learning and Champion of SPARC Europe. On a national level, she is a quality developer at the Swedish Institute for Standards (SIS) and for ISO. She is a member of the Digital Skills and Jobs Coalition Sweden and Vice President of the Swedish Association for Distance Education. She is currently working on a government initiative on quality in distance education at the National Council for Higher Education. She holds a Ph.D. from the University of Oulu, Finland.",institutionString:"Swedish Association for Distance Education, Sweden",institution:null},editorTwo:null,editorThree:null,editorialBoard:[{id:"320585",title:"Ph.D.",name:"Deborah",middleName:null,surname:"Young",slug:"deborah-young",fullName:"Deborah Young",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002vZLcTQAW/Profile_Picture_2022-05-10T08:30:47.jpg",institutionString:"Empowering Communities Globally",institution:null},{id:"348038",title:"Associate Prof.",name:"Feyza",middleName:null,surname:"Bhatti",slug:"feyza-bhatti",fullName:"Feyza Bhatti",profilePictureURL:"https://mts.intechopen.com/storage/users/348038/images/system/348038.jpg",institutionString:"Girne American University",institution:{name:"Girne American University",institutionURL:null,country:{name:"Cyprus"}}},{id:"302382",title:"Dr.",name:"Gina",middleName:null,surname:"Alvarado",slug:"gina-alvarado",fullName:"Gina Alvarado",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002mZoL9QAK/Profile_Picture_2022-05-26T08:14:10.jpg",institutionString:"Landesa, Seattle",institution:null},{id:"128665",title:"Prof.",name:"Man-Chung",middleName:null,surname:"Chiu",slug:"man-chung-chiu",fullName:"Man-Chung Chiu",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bR9OrQAK/Profile_Picture_2022-03-09T08:36:59.JPG",institutionString:null,institution:{name:"Beijing Normal University",institutionURL:null,country:{name:"China"}}}]},{id:"94",title:"Climate Change and Environmental Sustainability",coverUrl:"https://cdn.intechopen.com/series_topics/covers/94.jpg",editor:{id:"61855",title:"Dr.",name:"Yixin",middleName:null,surname:"Zhang",slug:"yixin-zhang",fullName:"Yixin Zhang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYWJgQAO/Profile_Picture_2022-06-09T11:36:35.jpg",biography:"Professor Yixin Zhang is an aquatic ecologist with over 30 years of research and teaching experience in three continents (Asia, Europe, and North America) in Stream Ecology, Riparian Ecology, Urban Ecology, and Ecosystem Restoration and Aquatic Conservation, Human-Nature Interactions and Sustainability, Urbanization Impact on Aquatic Ecosystems. He got his Ph.D. in Animal Ecology at Umeå University in Sweden in 1998. He conducted postdoc research in stream ecology at the University of California at Santa Barbara in the USA. After that, he was a postdoc research fellow at the University of British Columbia in Canada to do research on large-scale stream experimental manipulation and watershed ecological survey in temperate rainforests of BC. He was a faculty member at the University of Hong Kong to run ecological research projects on aquatic insects, fishes, and newts in Tropical Asian streams. He also conducted research in streams, rivers, and caves in Texas, USA, to study the ecology of macroinvertebrates, big-claw river shrimp, fish, turtles, and bats. Current research interests include trophic flows across ecosystems; watershed impacts of land-use change on biodiversity and ecosystem functioning; ecological civilization and water resource management; urban ecology and urban/rural sustainable development.",institutionString:null,institution:{name:"Soochow University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null,editorialBoard:null},{id:"95",title:"Urban Planning and Environmental Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/95.jpg",editor:{id:"181079",title:"Dr.",name:"Christoph",middleName:null,surname:"Lüthi",slug:"christoph-luthi",fullName:"Christoph Lüthi",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRHSqQAO/Profile_Picture_2022-04-12T15:51:33.png",biography:"Dr. Christoph Lüthi is an urban infrastructure planner with over 25 years of experience in planning and design of urban infrastructure in middle and low-income countries. 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He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. Voyich",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Montana State University",country:{name:"United States of America"}}},{id:"330412",title:"Dr.",name:"Muhammad",middleName:null,surname:"Farhab",slug:"muhammad-farhab",fullName:"Muhammad Farhab",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"349495",title:"Dr.",name:"Muhammad",middleName:null,surname:"Ijaz",slug:"muhammad-ijaz",fullName:"Muhammad Ijaz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}}]}},subseries:{item:{id:"95",type:"subseries",title:"Urban Planning and Environmental Management",keywords:"Circular economy, Contingency planning and response to disasters, Ecosystem services, Integrated urban water management, Nature-based solutions, Sustainable urban development, Urban green spaces",scope:"
\r\n\tIf we aim to prosper as a society and as a species, there is no alternative to sustainability-oriented development and growth. Sustainable development is no longer a choice but a necessity for us all. Ecosystems and preserving ecosystem services and inclusive urban development present promising solutions to environmental problems. Contextually, the emphasis on studying these fields will enable us to identify and define the critical factors for territorial success in the upcoming decades to be considered by the main-actors, decision and policy makers, technicians, and public in general.
\r\n
\r\n\tHolistic urban planning and environmental management are therefore crucial spheres that will define sustainable trajectories for our urbanizing planet. This urban and environmental planning topic aims to attract contributions that address sustainable urban development challenges and solutions, including integrated urban water management, planning for the urban circular economy, monitoring of risks, contingency planning and response to disasters, among several other challenges and solutions.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/95.jpg",hasOnlineFirst:!1,hasPublishedBooks:!1,annualVolume:11979,editor:{id:"181079",title:"Dr.",name:"Christoph",middleName:null,surname:"Lüthi",slug:"christoph-luthi",fullName:"Christoph Lüthi",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRHSqQAO/Profile_Picture_2022-04-12T15:51:33.png",biography:"Dr. Christoph Lüthi is an urban infrastructure planner with over 25 years of experience in planning and design of urban infrastructure in middle and low-income countries. He holds a Master’s Degree in Urban Development Planning from the University College of London (UCL), and a Ph.D. in Urban Planning & Engineering from TU Berlin. He has conducted applied research on urban planning and infrastructure issues in over 20 countries in Africa and Asia. In 2005 he joined Eawag-Sandec as Leader of the Strategic Environmental Sanitation Planning Group. Since 2015 he heads the research department Sanitation, Water and Solid Waste for Development (Sandec) at the Swiss Federal Institute of Aquatic Research and Technology (Eawag).",institutionString:"Swiss Federal Institute of Aquatic Science and Technology, Switzerland",institution:null},editorTwo:{id:"290571",title:"Dr.",name:"Rui Alexandre",middleName:null,surname:"Castanho",slug:"rui-alexandre-castanho",fullName:"Rui Alexandre Castanho",profilePictureURL:"https://mts.intechopen.com/storage/users/290571/images/system/290571.jpg",biography:"Rui Alexandre Castanho has a master\\'s degree in Planning, Audit, and Control in Urban Green Spaces and an international Ph.D. in Sustainable Planning in Borderlands. Currently, he is a professor at WSB University, Poland, and a visiting professor at the University of Johannesburg, South Africa. Dr. Castanho is a post-doc researcher on the GREAT Project, University of Azores, Ponta Delgada, Portugal. 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