The time duration in hours when the sun is in the three elevation angle intervals, calculated monthly for the first part of the year in Trondheim.
\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"6068",leadTitle:null,fullTitle:"Coronary Artery Bypass Graft Surgery",title:"Coronary Artery Bypass Graft Surgery",subtitle:null,reviewType:"peer-reviewed",abstract:"The book Coronary Artery Bypass Graft Surgery is an excellent update for health care professionals, taking care of patients who are being considered for or who have had coronary artery bypass graft surgery. The 8 chapters in this book are all written by experts in their topics. This excellent book provides the practicing physician and other healthcare personnel, who take care of patients with coronary artery disease, new information valuable in care of patients with coronary artery disease.",isbn:"978-953-51-3710-8",printIsbn:"978-953-51-3709-2",pdfIsbn:"978-953-51-4026-9",doi:"10.5772/68027",price:119,priceEur:129,priceUsd:155,slug:"coronary-artery-bypass-graft-surgery",numberOfPages:186,isOpenForSubmission:!1,isInWos:1,isInBkci:!0,hash:"1fc460064df1f705a67a5e583524f982",bookSignature:"Wilbert S. Aronow",publishedDate:"December 20th 2017",coverURL:"https://cdn.intechopen.com/books/images_new/6068.jpg",numberOfDownloads:15860,numberOfWosCitations:7,numberOfCrossrefCitations:3,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:5,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:15,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 28th 2017",dateEndSecondStepPublish:"March 21st 2017",dateEndThirdStepPublish:"September 22nd 2017",dateEndFourthStepPublish:"October 22nd 2017",dateEndFifthStepPublish:"December 22nd 2017",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,8",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"164597",title:"Dr.",name:"Wilbert S.",middleName:null,surname:"Aronow",slug:"wilbert-s.-aronow",fullName:"Wilbert S. Aronow",profilePictureURL:"https://mts.intechopen.com/storage/users/164597/images/system/164597.jpg",biography:"Wilbert S. Aronow MD is Professor of Medicine and Director of Cardiology Research at Westchester Medical Center and New York Medical College. He has edited 19 books and is the author or co-author of 1,817 papers or book chapters, 752 commentaries, 50 Letters to the Editor, and 1166 abstracts. He has been a member of 185 editorial boards of medical journals. He has been a member of four national guidelines committees. He was a co-author of a 2015 position paper from the International Lipid Expert Forum. He has been a member of the Board of Directors of the ASPC, a committee member of numerous professional societies, and a consultant to many government agencies.",institutionString:"New York Medical College and Westchester Medical Center",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"5",institution:{name:"New York Medical College",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1141",title:"Cardiothoracic Surgery",slug:"cardiothoracic-surgery"}],chapters:[{id:"56834",title:"Evaluation of Coronary Artery Bypass by CT Coronary Angiography",doi:"10.5772/intechopen.70439",slug:"evaluation-of-coronary-artery-bypass-by-ct-coronary-angiography",totalDownloads:2188,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Coronary computed tomography angiography (CCTA) is an accurate method for graft imaging and assessment than invasive coronary angiography (ICA). CTA has excellent sensitivity and specificity. The chapter describes the role of CTA in evaluation of coronary bypass graft. It covers the appropriate indications for performing CTA after bypass operation, patient preparation, as well as protocol and technique of CTA. The chapter describes the post-examination processing of the images and how to interpret CTA images for detection of graft patency or dysfunction as occlusion, partial thrombosis, poor blood flow, and stealing flow from native artery. According to the American College of Cardiology, the American College of Radiology, and the North American Society for Cardiovascular Imaging, graft patency assessment with CTA is an appropriate approach in symptomatic patients at risk for graft stenosis/occlusion. Cardiac CT can be used to assess the patency of coronary artery bypass graft (CABG) with high diagnostic accuracy compared with ICA and even with a better performance compared to the assessment of native coronaries.",signatures:"Ragab Hani Donkol, Zizi Saad Mahmoud and Mohammed Elrawy",downloadPdfUrl:"/chapter/pdf-download/56834",previewPdfUrl:"/chapter/pdf-preview/56834",authors:[{id:"73459",title:"Prof.",name:"Ragab",surname:"Donkol",slug:"ragab-donkol",fullName:"Ragab Donkol"},{id:"214773",title:"Dr.",name:"Zizi",surname:"Saad Mahmoud",slug:"zizi-saad-mahmoud",fullName:"Zizi Saad Mahmoud"},{id:"215357",title:"Dr.",name:"Mohammed",surname:"Elrawy",slug:"mohammed-elrawy",fullName:"Mohammed Elrawy"}],corrections:null},{id:"56664",title:"The Choice of Graft Conduits in Coronary Artery Bypass Grafting",doi:"10.5772/intechopen.70398",slug:"the-choice-of-graft-conduits-in-coronary-artery-bypass-grafting",totalDownloads:1675,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The use of the left internal mammary artery (IMA) has been shown to improve long-term survival and has been a gold standard in coronary artery bypass grafting (CABG). However, the choice of second or third graft conduit is still controversial. Multiple studies demonstrated the benefit of using multiple arterial grafts such as right IMA and radial artery in addition to left IMA in terms of long-term survival and graft patency. However, most of the centers still perform CABG with one IMA and vein grafts in a real world. The challenges for bilateral IMA utilization include longer operative time and concerns for higher rates of perioperative morbidity and mortality associated with increased sternal wound infection. Several studies reported that skeletonization technique can reduce the risk of sternal wound infection. Radial artery is another arterial conduit, which does not increase the risk of sternal wound infection and is easy to harvest. The superiority between radial artery and right IMA has been controversial. In the meantime, multiple trials have been made to improve the patency of vein grafts. The choice of graft conduits in CABG should be well considered preoperatively based on each patient’s backgrounds.",signatures:"Takashi Murashita",downloadPdfUrl:"/chapter/pdf-download/56664",previewPdfUrl:"/chapter/pdf-preview/56664",authors:[{id:"192448",title:"Dr.",name:"Takashi",surname:"Murashita",slug:"takashi-murashita",fullName:"Takashi Murashita"}],corrections:null},{id:"58131",title:"Left Main Coronary Artery Disease: Current Treatment Options",doi:"10.5772/intechopen.71562",slug:"left-main-coronary-artery-disease-current-treatment-options",totalDownloads:2487,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Significant left main coronary artery disease is defined as a greater than 50% angiographic narrowing of the vessel. In general, there are three options for the treatment of LMCA disease which include optimal medical therapy, percutaneous revascularization, or surgical revascularization, either off-pump or on-pump. It is the highest-risk lesion subset of ischemic heart disease and until recent years, coronary artery bypass grafting was the major choice of treatment. Although there is a marked increase in use of percutaneous coronary intervention in left main disease, there are still some questions about its efficacy when compared with surgery. Although bypass surgery is the gold standard, current treatment guideline recommendations canalized the treatment of this potentially lethal disease into percutaneous interventions in selected patients who had low to intermediate anatomic complexity. Left main disease with low SYNTAX scores (≤22) can be treated either by bypass surgery or percutaneously, whereas SYNTAX score > 32 is an indication for only coronary artery bypass surgery. The heart team should always be in collaboration, give therapeutic options to patients and decide the best treatment strategy for the welfare of the patient.",signatures:"Omer Tanyeli",downloadPdfUrl:"/chapter/pdf-download/58131",previewPdfUrl:"/chapter/pdf-preview/58131",authors:[{id:"207372",title:"Dr.",name:"Omer",surname:"Tanyeli",slug:"omer-tanyeli",fullName:"Omer Tanyeli"}],corrections:null},{id:"56794",title:"Coronary Artery Bypass Grafting in Patients with Diabetes Mellitus: A Cardiologist’s View",doi:"10.5772/intechopen.70416",slug:"coronary-artery-bypass-grafting-in-patients-with-diabetes-mellitus-a-cardiologist-s-view",totalDownloads:1493,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The review presents current data on the prevalence of diabetes in the cohort of patients undergoing coronary artery bypass grafting. The relevance of active approach to the identification of diabetes and prediabetes in patients with coronary artery disease (CAD) before coronary revascularization is reviewed. Recent information about the negative impact of diabetes on the prognosis of myocardial revascularization is reported as well as the main mechanisms responsible to the development of adverse outcomes of interventions in these patients. Target perioperative values of glycemia recommended by the leading associations of the study of diabetes have been compared. Beneficial potential of other carbohydrate metabolism markers (glycated hemoglobin, fructosamine, 1,5-anhydroglucitol) in patients with diabetes mellitus (DM) in terms of their impact on cardiovascular prognosis, including coronary intervention. The results of studies comparing different management strategies for these patients are reviewed. The significance of carbohydrate metabolism compensation during myocardial revascularization is reported; thus, a too stringent glycemic control has no benefits neither for percutaneous nor for open coronary intervention. Recent trials suggest the groups of antidiabetic drugs and evidence of their impact on the cardiovascular system. The importance of comprehensive monitoring of major risk factors in diabetic patients with coronary intervention has been proved.",signatures:"Bezdenezhnykh Natalia Alexandrovna, Sumin Alexei Nikolaevich,\nBezdenezhnykh Andrey Viktorovich and Barbarash Olga\nLeonidovna",downloadPdfUrl:"/chapter/pdf-download/56794",previewPdfUrl:"/chapter/pdf-preview/56794",authors:[{id:"206416",title:"Dr.",name:"Natalia",surname:"Bezdenezhnykh",slug:"natalia-bezdenezhnykh",fullName:"Natalia Bezdenezhnykh"},{id:"207219",title:"Prof.",name:"Alexei",surname:"Sumin",slug:"alexei-sumin",fullName:"Alexei Sumin"},{id:"207222",title:"Prof.",name:"Olga",surname:"Barbarash",slug:"olga-barbarash",fullName:"Olga Barbarash"},{id:"207321",title:"Dr.",name:"Andrey",surname:"Bezdenezhnykh",slug:"andrey-bezdenezhnykh",fullName:"Andrey Bezdenezhnykh"}],corrections:null},{id:"58188",title:"Coronary Artery Bypass and Stroke: Incidence, Etiology, Pathogenesis, and Surgical Strategies to Prevent Neurological Complications",doi:"10.5772/intechopen.72389",slug:"coronary-artery-bypass-and-stroke-incidence-etiology-pathogenesis-and-surgical-strategies-to-prevent",totalDownloads:1491,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Current data suggest that cardiac bypass surgery is the single largest cause of iatrogenic stroke. Among the strategies to decrease or eliminate aortic manipulation, there is the use of off-pump coronary artery bypass grafting (CABG) through an aortic “no touch” technique, which reduces significantly the stroke rate. However, this off-pump aortic “no touch” technique is not always applicable, and, when saphenous vein and/or free arterial aortocoronary grafts are used, there is still risk of neurological injury due to tangential aortic clamp applied during the proximal anastomosis sewing. We aim to analyze the current incidence, etiology, and physiopathology of the neurological complications after coronary artery bypass surgery. We describe the methods and techniques that provide reduction in the occurrence of neurological complications. CABG with multiple clamp technique failed to find a better outcome in terms of neuropsychological deficit in the OPCABG group. By the way, patients undergoing CABG with single clamping seems to have better outcomes, suggesting that the cross-clamping technique used and minimal aortic manipulation could have had a role in reducing neurocognitive impairment. Moreover, surprisingly, CPB seemed to be a neuroprotective factor, and this aspect could be linked to the mild hypothermia used during on-pump surgery.",signatures:"Marco Gennari, Gianluca Polvani, Tommaso Generali, Sabrina\nManganiello, Gabriella Ricciardi and Marco Agrifoglio",downloadPdfUrl:"/chapter/pdf-download/58188",previewPdfUrl:"/chapter/pdf-preview/58188",authors:[{id:"57128",title:"Dr.",name:"Marco",surname:"Gennari",slug:"marco-gennari",fullName:"Marco Gennari"}],corrections:null},{id:"56902",title:"Arrhythmias Post Coronary Artery Bypass Surgery",doi:"10.5772/intechopen.70423",slug:"arrhythmias-post-coronary-artery-bypass-surgery",totalDownloads:2479,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Arrhythmias are common after cardiac surgery such as coronary artery bypass grafting surgery. Although most of these arrhythmias are transient and have a benign course, it may represent a significant source of morbidity and mortality. Postoperative arrhythmias (POAs) include atrial tachyarrhythmias, ventricular arrhythmias, and bradyarrhythmias. The incidence of POAs has not changed despite improvements in anesthetic and surgical techniques. The tachyarrhythmias in the postoperative period include atrial fibrillation, atrial flutter, supraventricular tachycardia, and ventricular tachycardia. The clinical significance of each arrhythmia depends on several factors that include cardiac function, patient’s comorbidities, arrhythmia duration, and ventricular response rate. Tachycardia with uncontrolled ventricular rates can cause diastolic and later on systolic dysfunction, reduce cardiac output, and result in hypotension or myocardial ischemia. In the other hand, bradyarrhythmias may have a remarkable influence on patients with systolic or diastolic ventricular dysfunction. Arrhythmia management starts preoperatively with optimizing the patient’s condition and controlling patient’s risk factors, intra-operatively with careful attention to hemodynamic changes during surgery and uses appropriate anesthesia, and postoperatively with correction of temporary and correctable predisposing factors, as well as specific therapy for the arrhythmia itself. The POAs treatment urgency and management options are determined by the clinical presentation of the arrhythmia.",signatures:"Bandar Al-Ghamdi",downloadPdfUrl:"/chapter/pdf-download/56902",previewPdfUrl:"/chapter/pdf-preview/56902",authors:[{id:"189192",title:"Prof.",name:"Bandar",surname:"Al-Ghamdi",slug:"bandar-al-ghamdi",fullName:"Bandar Al-Ghamdi"}],corrections:null},{id:"57760",title:"Physical Training Programs After Coronary Artery Bypass Grafting",doi:"10.5772/intechopen.71978",slug:"physical-training-programs-after-coronary-artery-bypass-grafting",totalDownloads:1943,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Exercise-based rehabilitation is considered an important adjunct therapy for secondary prevention in patients with coronary artery disease, mainly in populations with coronary artery bypass graft (CABG) and percutaneous coronary intervention. Thus, the increasing number of cardiac surgeries along the years is enlarging the participation of patients in cardiac rehabilitation programs. Encouraging exercise-based cardiac rehabilitation might decreases in-hospital stay, speeds returns to work and reduces costs in public health. Recently, two training modalities of exercise gained much attention in cardiac rehabilitation programs: continuous exercise and high-intensity interval aerobic training (HIIAT). The aim of this chapter is to review the effects of HIIAT in patients that undergone to CABG or other cardiac surgeries regarding clinical and physiological parameters such as death, cardiovascular outcomes, aerobic capacity, anaerobic capacity, quality of life and other parameters, beyond to evaluate the feasibility and safety of HIIAT in this patient’s group.",signatures:"Aikawa Priscila, Nakagawa Naomi Kondo, Mazzucco Guillermo,\nPaulitsch Renata Gomes and Paulitsch Felipe da Silva",downloadPdfUrl:"/chapter/pdf-download/57760",previewPdfUrl:"/chapter/pdf-preview/57760",authors:[{id:"67407",title:"Prof.",name:"Naomi Kondo",surname:"Nakagawa",slug:"naomi-kondo-nakagawa",fullName:"Naomi Kondo Nakagawa"},{id:"127508",title:"Dr.",name:"Priscila",surname:"Aikawa",slug:"priscila-aikawa",fullName:"Priscila Aikawa"},{id:"207394",title:"Dr.",name:"Felipe",surname:"Paulitsch",slug:"felipe-paulitsch",fullName:"Felipe Paulitsch"},{id:"220151",title:"BSc.",name:"Guillermo",surname:"Mazzucco",slug:"guillermo-mazzucco",fullName:"Guillermo Mazzucco"},{id:"220152",title:"MSc.",name:"Renata Gomes",surname:"Paulitsch",slug:"renata-gomes-paulitsch",fullName:"Renata Gomes Paulitsch"}],corrections:null},{id:"57784",title:"Medical and Surgical Management and Outcomes for Coronary Artery Disease",doi:"10.5772/intechopen.71979",slug:"medical-and-surgical-management-and-outcomes-for-coronary-artery-disease",totalDownloads:2106,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Coronary artery disease (CAD) is a major cause of death and disability in developed countries. Although coronary artery disease mortality rates worldwide have declined over the past decades, CAD remains responsible for about one third or more of all deaths in individuals over the age of 35 years. Various methods of treatment have been proposed including medical therapy, catheter-based interventions, and lastly, coronary artery bypass grafting. The purpose of this chapter is to outline those treatment regimens and examine the literature detailing their outcomes in hopes of guiding treatment.",signatures:"Allan Mattia and Frank Manetta",downloadPdfUrl:"/chapter/pdf-download/57784",previewPdfUrl:"/chapter/pdf-preview/57784",authors:[{id:"219621",title:"Dr.",name:"Frank",surname:"Manetta",slug:"frank-manetta",fullName:"Frank Manetta"},{id:"220462",title:"Dr.",name:"Allan",surname:"Mattia",slug:"allan-mattia",fullName:"Allan Mattia"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"3542",title:"Artery Bypass",subtitle:null,isOpenForSubmission:!1,hash:"6b48ec67e1291ca98f3aded6a9af92ca",slug:"artery-bypass",bookSignature:"Wilbert S. Aronow",coverURL:"https://cdn.intechopen.com/books/images_new/3542.jpg",editedByType:"Edited by",editors:[{id:"164597",title:"Dr.",name:"Wilbert S.",surname:"Aronow",slug:"wilbert-s.-aronow",fullName:"Wilbert S. Aronow"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3815",title:"Cardiac Arrhythmias",subtitle:"Mechanisms, Pathophysiology, and Treatment",isOpenForSubmission:!1,hash:"fe6dad804d0257a3922593b7861a1b74",slug:"cardiac-arrhythmias-mechanisms-pathophysiology-and-treatment",bookSignature:"Wilbert S. Aronow",coverURL:"https://cdn.intechopen.com/books/images_new/3815.jpg",editedByType:"Edited by",editors:[{id:"164597",title:"Dr.",name:"Wilbert S.",surname:"Aronow",slug:"wilbert-s.-aronow",fullName:"Wilbert S. 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Coordinator for Post Graduate programs of the Faculty of Business (March 2006-April 2014), Chairperson of Center for Globalization and Sustainability Research (CGSR) (March2009-April2014), Multimedia University (MMU), Melaka Campus, Malaysia, member of Research and Development, research grants panel and the Institute of Postgraduate Studies (IPS) Coordination Committee (ICC) MMU. He is currently teaching Advanced Research Methodology, Entrepreneurship and Commercialization, and Economics for Managers at the postgraduate level and economic subjects at the undergraduate level.\nHis research interests include development economics, productivity analysis, knowledge-based economy, productivity and environment (green productivity), Bioeconomy, Islamic finance and microfinance, economic growth, (environment, tourism) and Entrepreneurship. He is the book\\'s author (Green Productivity: Applications in Malaysia’s Manufacturing) in 2012. 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For many years the focus in daylighting research has been at daylight level and daylight distribution in buildings. By adjusting these two parameters with a control system of electrical light and shading devices, a substantial amount of savings in energy consumption can be made possible. But the subject of daylighting also includes other issues like: view out, visual comfort and accessibility of sunlight in interiors as important parameters of occupant’s health, well-being and aesthetical satisfaction.
\nResearch shows that daylight is advantageous (vs. electrical light) for visual tasks if it is delivered in a comfortable manner. It may create even and intense illumination enabling ideal conditions for visual tasks such as reading. Daylight is also the best light source for colour discrimination. The variation of daylight during the day stimulates the visual system and conveys information about weather fluctuation and the passing of time. The view out through the window is important for orientation and for keeping in contact with the outdoor environment; as such it is one of factors influencing the mental health of occupants.
\nDaylight is also crucial for non-visual neural system that is stimulated by the light falling at the special type of light-sensitive neural cells in the retina called intrinsically photosensitive retinal ganglion cells (ipRGC) [1]. The nerve impulses conveying information about light detected by those cells contribute to regulation of hormone production and to adjustment of human circadian rhythm to the 24 h cycle. The circadian rhythm is decisive for good functioning of our body and brain. Daylight is the optimal light source for stimulation of the non-visual system since it has a very high intensity and a spectrum containing much light in the blue-green part of the visual spectrum to which the non-visual system is most sensitive. As the morning daylight exposure of ipRGCs is most effective for the circadian rhythm adjustment, high daylighting level in rooms where we stay in the morning, as e.g. bedrooms, is especially important. Finally, we may underscore that importance of daylight for the health of occupants should be considered including both, visual and non-visual systems, which are two separate nerve paths, both receiving impulses from the retina in the eye but processing them differently in the brain.
\nAs the adequate light exposure during the day is important for sleep length and sleep quality, and adequate duration of sleep is important for cognitive activity as, e.g. learning, it is logical to expect that adequately daylit buildings may contribute to better performance of occupants. Such correlations were actually found.
\nConsidering daylighting solutions the local climate has to be taken into consideration, this topic is limited here to the region encompassing Nordic European countries.
\nLet us start with the most important parameter that has impact at other parameters, i.e. the position of the sun. It may be observed that three national capitals and other large towns in northern Europe have latitudes close to 60°: Oslo 59°54′, Stockholm 59°19′, Helsinki 60°10′, Bergen 60°22′ and Orebro 59°16′.
\nEven a momentary look at the sun diagram for one of those cities, e.g. Oslo, and the sun diagram for, say, Cairo, helps to find the most fundamental difference between daylight in the North and in the South, i.e. the prevailing height of the sun over the horizon. The sun moves straight up after sunrise in Cairo. In Oslo the movement is more horizontal; the elevation angle of the sun increases slowly over many hours and never reaches the area around the zenith. The highest position of the sun during the year in Oslo is 53.53°, the elevation angle at noon at the equinox is only 30.52°, while the two respective angles for Cairo are 83.37° and 60.33°.
\nAnother interesting aspect is related to timing of the solar elevation angle. Since the position of the sun in Nordic countries is very low, the sun is near the horizon considerably longer than in countries situated at lower latitudes as, e.g. Cairo, 30°03′N. The very interesting question is how long can we expect the sun to be, e.g. between 0° and 10° above the horizon? The calculations of the percentage of daytime occurring during the first part of the year when the elevation angle of the sun is in intervals—(0°–10°), (10° –30°) and (over 30°)—were made with the help of the Solar Beam software [2] for Trondheim: 63°26’, see Figure 1. The results are also presented in Table 1.
\nThe sun diagram for Cairo and Trondheim generated using the Solar Beam software. The area of the Trondheim diagram representing 0–10° elevation angles of the sun is marked with red and the area representing elevation angles over 30° with yellow colour.
The highest elevation angle of the sun during the shortest day of the year, 21st of December, is only 3,35°. In the period from the 21st of December to the beginning of February the elevation angle of the sun will never reach 10°, this occurs first on the 3rd of February. After this day the number of hours when the sun is over 10° increases rapidly on a daily basis, but 30° sun elevation angle cannot be observed before the 30th of March.
\nThe highest position of the sun in Trondheim is 50.01°. There are only four days during the year, 19th, 20th, 21st and 22nd of June, when the elevation angle of the sun is slightly higher than 50°; at 21st of June it lasts for 12 min.
\n\n\nThe results are striking: the percentage of time during the year when the sun is between 0° and 10° is 35%. This means that for more than 1/3 of the whole daytime during the year we may expect a nearly horizontal light from the sun. The time when the sun is in the 0–10° angle interval is actually much longer than the time when it is over 30° (26%).
\n\n | 0–10° | \n10–30° | \n30–50° | \n0–50° | \nTwilight | \n
---|---|---|---|---|---|
December 21–31 | \n50.1 | \n0 | \n0 | \n50.1 | \n27.2 | \n
January | \n179.9 | \n0 | \n0 | \n179.9 | \n66.5 | \n
February | \n134.0 | \n108.2 | \n0 | \n242.1 | \n47.6 | \n
March | \n104.0 | \n257.9 | \n2.8 | \n364.7 | \n48.8 | \n
April | \n100.0 | \n202.9 | \n146.8 | \n449.7 | \n55.3 | \n
May | \n124.7 | \n190.4 | \n248.3 | \n563.4 | \n106.8 | \n
June 01–21 | \n102.4 | \n131.4 | \n191.8 | \n425.6 | \n78.40 | \n
Together: | \n794.9 | \n890.8 | \n589.7 | \n2275.5 | \n430.42 | \n
\n |
The time duration in hours when the sun is in the three elevation angle intervals, calculated monthly for the first part of the year in Trondheim.
The availability of the sunlight is also strongly dependent on the cloud cover. To look at the frequency of sunny skies a map was generated with the help of the Satel-Light [3], see Figure 2.
\nThe analysis made so far shows the typical features of daylight in the Nordic countries:
\nDominating low solar elevation angle during the year.
Long periods of twilight and white nights in the time period close to summer solstice, midnight sun at places north of the Arctic Circle.
Rather low frequency of sunny skies during the year, especially during winter.
Frequency of sunny skies in North Europe.
A new method of harvesting daylight in the Nordic climate was developed during the retrofitting of a studio located at the campus of the Norwegian University of Science and Technology in Trondheim, Norway. The room is located on the third floor of a three storey building called Lavblokk Sør. The building is situated immediately south of a high raise 13 storey building, representing its largest exterior obstruction (Figure 3).
\nNTNU campus. The studio is marked by a red rectangle within the red ring.
The room is 8.2 m × 14.3 m, a total of 117 m2 and has a height of 3.4 m, as shown in Figures 4 and 5. It is one of eight student studios at the Faculty of Architecture. The students use them as permanent working places; the typical visual tasks are drawing, making sketch models and of course reading and writing both in the analogue and digital format.
\nThe cross-section of the room.
The layout of the room with drawing tables for 24 students. Location of skylights is marked with dashed squares. The dashed lines represent steel beams.
The roof construction is made of steel beams situated across the room, as shown in Figures 4 and 5. There are four skylights in the rear part of the room. The original idea behind skylights was to deliver daylight in the rear part of the room and to protect against direct sunlight falling at working areas. This was achieved by the usage of translucent acrylic sandwich elements in the pyramid-shaped skylights. Skylights are square in plan 1.8 m × 1.8 m; the height of vertical walls surrounding each roof opening, the well, is 0.85 m.
\nThe acrylic sandwich elements diffuse sunlight very well, but they have also a negative feature, namely, the total transmittance of light is low, i.e. sandwich elements transmittance is 30–40% depending on the thickness of material, something that limits daylight penetration during cloudy weather which, as was shown in introduction, occurs in Trondheim quite often.
\nAfter including this refurbishment project in the research activity of the Light & Colour Group, specifically in the DayLighting project carried in international cooperation, in the frame of IEA Task 50 “Advanced solutions for retrofitting of lighting systems” [4], the scope of the project has been widely extended.
\nThe main objectives of the refurbishment project were to:
\nKeep the energy consumption for heating at the same or lower level. It should be mentioned that since the climate in Trondheim is rather cold and a high rise building is situated to the south, there was no need for cooling in the studio.
Maximize the provision of daylight, both sunlight and diffuse light from the sky; this is to enable a reduction of energy consumption for electrical lighting.
Create good visual conditions for all occupants in the room in any daylight condition.
The scope of the project was originally limited to replacement of dirty old acrylic sandwich elements with two-layers low-energy glass (Figure 6).
\nExisting skylights from the outside and from the inside.
To minimize the energy consumption for heating three-layers low-energy glass was chosen instead of two-layers such that the U-value of the new glazing, specified at the middle of the glass, has been 0.9 W/m2K.
\nThe estimated transmittance of old sandwich elements is in the range 20–40% depending on the dirt thickness and age (yellowing of material) while the transmittance of the new glazing oscillates around 70% depending on maintenance frequency. To maximize the daylight provision the low-iron glass was chosen to keep the light transmittance of the glazing at the topmost level (about 4% increase comparing to the standard glass).
\nThe vertical well walls have been covered with highly reflective mirrors, R = 96%. Such a solution ensures that all of the light hitting surfaces of the mirrors is reflected down, i.e. not a single ray is reflected back to the atmosphere. This is especially important in the location with dominating low sun.
\nThe most challenging task was to ensure the visual comfort. The sunlight passing through the glazing and reflected from mirrors would create patches of strong sunlight in the interior. The patches would move in the room as the sun moves on the sky. The crucial question was how to distribute the sunlight in the room and at the same time keep the skylight transmittance at topmost level?
\nTo obtain the most promising solution different alternatives were tested in a scale-model study carried out in the Daylight Lab. at NTNU, Light & Colour Group. The alternatives assumed utilization of perfectly transparent acrylic plates which have been perforated with holes made with the Laser Cutting Machine accessible at the workshop at the Faculty of architecture, NTNU.
\nAfter the idea of scattering sunlight with the help of perforated acrylic plates proved to be successful, a long design process followed. A suspension system for hanging the plates exactly at the level needed to be aligned with the ceiling plates had to be designed. The size of the acrylic plates had to be selected according to the dimensions of the skylight well. The thickness of the plates had to be chosen according to the size of the plates and the size of the holes and the distance between the holes had to be adjusted according to the thickness of the plates.
\nThe result of this project is shown in Figures 7 and 8. Pictures were taken with a Nikon D600 camera with the fish eye EX DG positioned at the entrance to the room about 2.0 m above the floor. Two rooms were photographed, the renovated room (on the left-hand side) and the neighbouring room that has not been renovated (on the right-hand side). A series of 11 low-dynamic range pictures were taken and combined afterwards into high-dynamic range HDR pictures. The HDR pictures visualize a room in a way that is much more similar to the way human visual system perceives it, especially regarding lightness of surfaces.
\n\nIt is clear that the general light level in the retrofitted room is significantly higher, both in the overcast and sunny conditions. This may be observed comparing the right and the left picture but also by looking at the high situated windows in the partition wall. The windows appear as darker than the wall if seen from the renovated room creating impression that we are looking into a darker room to the right; a contrary impression is created if the same windows are seen from the room which was not retrofitted.
\n\nAdditionally, the renovated room appear as cleaner, since the yellowish shade had been removed. Interestingly, the brightest spots in the renovated room are at acrylic panels, even very gentle sun patches on side walls appear as darker.
\nFish eye HDR pictures of the studio under overcast sky conditions, the new solution to the left, old one to the right.
Fish eye HDR pictures of the studio under clear sky conditions, the new solution to the left, old one to the right.
The refurbishment project is not completely finished; the next step will be the replacement of the electrical light system. New LED-luminaires will be fixed underneath the steel beams and will be connected to a daylight-responsive control system. This will allow theoretically the highest possible energy saving for lighting.
\nThe results of illuminance measurements taken in June 2016 at the middle of each numbered desk, see Figure 5, both in sunny and cloudy conditions are presented in Table 2. For cloudy conditions both illuminance and daylight factor (D) values are presented.
\nOn average the light level is increased by two to three times both in sunny and cloudy conditions. We predict similar values for intermittent sky, i.e. more than doubling of the light level. The daylight factor was increased from 2.1–2.3% in the room with the old solution to 4.8–6.9%.
\n\n | Sunny | \nCloudy | \n||||
---|---|---|---|---|---|---|
\n | New (lx) | \nOld (lx) | \nNew (lx) | \nD | \nOld (lx) | \nD | \n
1 | \n3145 | \n1655 | \n1306 | \n6.3% | \n454 | \n2.2% | \n
2 | \n3485 | \n1795 | \n992 | \n4.8% | \n435 | \n2.1% | \n
3 | \n3490 | \n1760 | \n1154 | \n5.6% | \n433 | \n2.1% | \n
4 | \n3110 | \n1730 | \n1417 | \n6.9% | \n456 | \n2.2% | \n
5 | \n3960 | \n2015 | \n1252 | \n6.1% | \n472 | \n2.3% | \n
6 | \n4300 | \n1900 | \n982 | \n4.8% | \n462 | \n2.2% | \n
7 | \n7535 | \n1820 | \n1109 | \n5.4% | \n431 | \n2.1% | \n
8 | \n4445 | \n1765 | \n1327 | \n6.4% | \n458 | \n2.2% | \n
Illuminance measured on eight desks situated closest to the entrance.
In sunny conditions, while the sun elevation angle is about 48°, the light level in the room with old skylights oscillates between 1600 and 2000 lx, in the room with the new solution it is around 3100–4400 lx. The variation in sunny conditions is higher as a very small percentage of light is allowed to pass directly through the acrylic panels creating a little brighter area (7535 lx).
\nAs the light level in the room with old skylights is rather low, doubling of this value makes daylight illumination much more adequate to the needs of the users (300–3000 lx). This means that the time of the daylight level on desks higher than 300 lx has been radically increased, giving large potential for energy saving for lighting.
\nThe research conducted by Ne’eman et al. [5] shows that acoustic, heating, lighting, outside view, ventilation, air conditioning and the design of work space are among the most important physical environmental factors affecting worker satisfaction. Daylighting and outside view, both conveyed by windows, are the most important factors for achieving worker satisfaction. The view out is especially important for well-being since it gives the possibility to keep contact with the outside environment continuously [6, 7].
\nThe existing hypotheses and research findings about preferences for view may be categorized into three groups: the need for information about the outside environment, the need for aesthetical experience and the need for restoration and health [8].
\nThe need for visual information is well described by Lam [9]. A typical window conveys information about location, time and weather conditions, but also about activities and events outside the building. If the need for visual information is not satisfied, the ability to focus on a work task is seriously limited.
\nThe need for aesthetical experience has been explained by the evolutionary aesthetics [10, 11] claiming that perceptions of beauty are evolutionarily determined, i.e. places and landscapes which people consider beautiful are typically found in settings that are likely to support survival of the human’s genes. This theory together with the prospect-refuge theory proposed by Appleton [12] may explain why natural landscapes and well-kept buildings are generally preferred.
\nThe need for restoration and health can be explained by the attention restoration theory [13]. Natural environments have qualities that in combination seldom occur in other types of environments. They give a feeling of being away and they create a sense of extend, i.e. what is seen is a part of a larger area. In addition, natural environments create a sense of fascination meaning that they encourage exploration, attract attention and hold it effortlessly [14, 15].
\nConsequently, for the evaluation of the view out, two categories of descriptors should be considered:
\nthe content of the outside view discussed previously, i.e. qualitative descriptors, and
the extent to which the view is actually available from a given point in the interior, i.e. quantitative descriptors.
Both types have impact on the view quality, see Tables 3 and 4, but the responsibility may be allocated to different professional groups. Architects designing a single building have responsibility for most quantitative descriptors, as e.g. the width of the view from a given place in the building as well as the possibility to see the view layers: sky, landscape and the ground. To a certain degree they may decide about the view distance, e.g. by choosing the location of the building on the site. Additionally, architects may attempt to include a nice landscape element in the views from many rooms. However, there are urban and landscape planners and municipalities who decide about the distance between buildings, width of the streets, size of town squares and have responsibility for creation of attractive urban or rural landscapes, i.e. are decisive for the qualitative descriptors.
\n\n | View quality | \n||
---|---|---|---|
Descriptor | \nSufficient | \nGood | \nExcellent | \n
> 14° | \n> 28° | \n> 54° | \n|
> 6 m | \n> 20 m | \n> 50 m | \n|
- sky - Landscape (urban and/or nature) - Ground | \nAt least landscape layer is included | \nMinimum two layers are included | \nAll layers are included | \n
- Location - Time - Weather - Nature - People | \nTime, weather and basic info about location | \nTime, weather, location and nature or people | \nAll | \n
Assessment of the view out, quantitative descriptors.
\n | View quality | \n||
---|---|---|---|
D | \nSufficient | \nGood | \nExcellent | \n
- urban low quality, as e.g. toward concrete walls, parking plot, etc. - urban middle quality - urban high quality, e.g. an attractive square or with attractive elements as, e.g. historical buildings, fountains, sculptures, etc. - natural/rural low quality, as e.g. monotonous rural landscape - natural/rural middle quality - natural/rural high quality, e.g. varied and including beautiful elements as lakes, well-shaped trees/bushes | \nNatural/rural –low or urban middle | \n Natural/rural -middle or urban high | \nNatural/rural -high or urban high | \n
- poor balance between landscape elements, e.g. more than ½ of the view is toward one dominating element - good balance - very good balance between landscape elements | \nPoor balance but at least the central part of the view is free from undesired elements. | \n Good balance and the central part of the view is free from undesired elements. | \nVery good balance and the view is free from undesired elements | \n
Assessment of the view out, qualitative descriptors.
It is preferable to divide the view out quality into classes, e.g. sufficient, good and excellent, see Table 3. For a good view it is recommended that the width of the view (window glass only) from the observation place in the room is larger than 28°, the mean minimum outdoor distance to other buildings/constructions is minimum 20 m and minimum two of the three view layers are included. If the evaluation of those metrics is difficult, it may help to consider if the view conveys environmental information about time, weather, location and nature or people, see the last row in Table 3.
\nAs discussed previously, for a view to meet the occupants’ needs for environmental information, for aesthetical experience and for restoration there are expectations to the quality of the view. Interesting question is then, how people evaluate quality of the view from their usual occupancy places. In the research study performed in a previous work [8] in Trondheim, Norway, over 100 subjects were visited at their work places and asked to evaluate the quality of the view out. The quality was best predicted by the view distance, the number of view layers, the quality of the landscape/elements and the composition of the view. This is a new finding showing that the aesthetical experience may be more important than assumed previously. Occupants appreciate the possibility of looking towards beautiful and well-maintained buildings and towards well-kept parks and gardens. It appears also that a certain degree of complexity is preferred. A variation in composition of green areas with different shapes and/or colours of trees and shrubs is preferred. Regarding buildings, a certain variation of forms and shapes is preferred compared to ordinary plain walls made of one material.
\nAnyhow, even if the view contains a beautiful element, like for example a cathedral, the important question is how much of this element is actually included in the view? Another question is if there are unwanted elements, like e.g. a poorly maintained building, in the view? With other words, how is the composition of the view? Where the liked and disliked elements are positioned, at the central or peripheral part of the view? A good method to find it out is simply to take pictures from the place under consideration. Table 4 gives additional guidance regarding the qualitative descriptors.
\nIt has to be mentioned that it may be also indirect determinants that influence people’s perception such as glare, colour rendering of glazing, contrast and clarity of the image which may have impact on the final evaluation of the quality of the view.
\nExperience-based knowledge gathered by generations of architects and building planners tells us that daylight has a profound impact upon the aesthetic ambience of the interiors. However, can this be scientifically proven? A full-scale study with mock-up rooms build in the Room Lab at NTNU in 2014 [16] examined the impact of window size and room reflectance on the perceived quality of a small room, and the correlation between various architectural quality attributes, as shown in Figure 9.
\nPictures of the mock-up rooms.
The mock-up rooms were visited in the randomized way by a number of carefully selected subjects. Statistical analysis of their answers led to the following conclusion: “overall, the rooms with larger windows and lighter walls obtained higher ratings for all the studied architectural quality attributes, suggesting that high levels of daylight are crucial in order to achieve a more pleasant, exciting, complex, legible, coherent, spacious, open and spatially defined room.” Additionally, it turned out that the window size was more important for the aesthetical judgement than the surface colour; on average the black room with the largest window scored higher than the white room with a small window. As this study was limited to rather small rooms, achromatic colours and overcast sky conditions, more research is needed for generalization.
\n\nAnother full-scale experiment was carried out in a small office room situated in one of high rise buildings on the NTNU campus to find out the aesthetical preferences of four different daylighting systems: venetian blinds (WB), high reflecting blinds (HRB), hybrid (included electrical light also) light shelf (HLS) and mirrored light shelf (MLS) [17], Figure 10. Results from MANOVA indicated that both the daylighting systems and the type of sky had an effect on the aesthetical attributes, and the significant interaction effect suggested that the aesthetical perception of daylighting systems depends on the type of sky. The room equipped with the high reflecting, i.e. specular, blind system, which created even and rather strong illumination, was evaluated highest by participants, i.e. as the most pleasant, exciting, coherent, spacious, legible and the one making the room most spatially defined, under both clear and overcast sky conditions.
\nPictures of the studied office rooms with the eight different stimuli.
The most prominent question in the study of daylighting is how to create rather high daylight level in cloudy conditions and avoid uncomfortable sunlight in sunny conditions in the same space. This is especially problematic when intense sunlight causes discomfort when shone on human bodies and distracts our view on computer screens. Sun shading devices are usually used to solve this problem, but this will cause the overall light level in the room to diminish and electrical light has to be used.
\nThe new system developed by the Light & Colour Group at NTNU [18] in Trondheim is based on the strategy of maximal penetration of daylight through the skylight, aided by vertical mirrors on the walls of the skylight well, which is scattered in the room using perforated acrylic plates. The results observed showed evenly distributed light of high intensity providing comfortable working conditions and significant energy saving when the use of electrical lighting is reduced. For high sun elevation angles which happen at the middle of the day during summer, sun patches may occur, especially on the side wall, but then they are weak and does not cause discomfort. In fact, they add luminance contrasts in the room and in this way increase esthetical experience. As the studied room has rather large windows towards trees, the good view is also ensured.
\nOur research confirms that there is clear potential for energy saving for lighting by utilization of daylight directly for illumination of interiors using canny designed skylights.
\nNatural products (NPs) and their derivatives constitute a significant fraction of approved drugs [1, 2, 3], bioactive compounds [4, 5, 6, 7, 8], and lead compounds for drug discovery [9]. NP fragment has been used to guide the synthesis of bioactive compounds and generate BIOS combinatorial libraries [10, 11, 12, 13, 14, 15]. NPs have structures with different substituent patterns, giving rise to different biological activities for compounds with very similar structures [16, 17, 18, 19]. These bioactive metabolites have greater affinity for biological targets and, overall, may have better bioavailability than synthetic compounds, and the presence of pan-assay interference compounds (PAIN) is less frequent in this type of product [20]. The chemoinformatic analysis of several databases of NPs developed by academic institutions and private companies [21] has been carried out in different countries. Thus, the following databases were obtained: BIOFACQUIM [22], CIFPMA [23], NuBBE [24, 25], NANPDB [26], TCM [27], HIT [28], and NPACT [29]. The application of chemoinformatic tools involves the generation, manipulation, and analysis of data set of chemical substances. This allows us through mathematical calculations to order, develop, and evaluate structural information that can be visualized in 2D and 3D [30]. The determination of the physicochemical properties carried out on different databases of NPs and principal component analysis (PCA) was used as an approximation to display the chemical spaces [22, 23, 24, 31, 32, 33, 34, 35, 36, 37].
Computational exploration of NPs has increased in recent years, giving greater relevance to studies that include structural diversity metrics calculated with parameters based on distances such as Euclidean distance, Manhattan distances, and Cosine distance. Other criteria are based on circular fingerprint (ECFP-4, ECFP-6) [22, 23, 24, 38, 39, 40, 41, 42, 43, 44, 45] and fingerprint based on substructure (MACCS, PubChem) [22, 23, 24, 39, 40, 41, 42, 43, 44, 45]. Another metric used in NPs is the comparison by similarity that uses the Tanimoto index/Tanimoto coefficient [22, 23, 24, 45, 46, 47, 48, 49].
In this study, the molecular scaffolds of natural products have been obtained using the Murcko method [22, 23, 24, 50, 51, 52, 53, 54, 55, 56, 57]. Meanwhile, the molecular complexity is frequently evaluated by descriptors in 2D such as fraction of sp3 hybridized carbons (Fsp3) [23], fraction of chiral centers (FCC) [23], and globularity [22, 23, 24, 58, 59, 60, 61, 62, 63].
An update of the Natural Products Database from the University of Panama (UPMA) containing 454 compounds (Unpublished data) has been evaluated against different therapeutic targets such as cytotoxicity bioassay in cell lines, antifungal assay in vitro, parasites of tropical diseases (
Biological endpoints and targets in which natural products from Panama present bioactivity.
In this chapter, we present a chemoinformatic analysis of natural products with antimalarial activities (in vitro), expressed as pIC50 against sensitive and resistant strains. Databases of natural products with antimalarial activity (NPAs) were constructed in-house by reviewing published articles including those compounds that were isolated and characterized by spectroscopic techniques of nuclear magnetic resonance. Around 1312 compounds were compared to 8 reference data sets: an open database, DrugBank (antimalarial drug), European Bioinformatics Institute. (CHEMBL drug indications) (antimalarial activities), Open Source Drug Discovery (OSDD) Malaria, Malaria Box (Medicines for Malaria Venture (MMV)), St. Jude Children’s Research Hospital (St. Jude), Novartis (GNF Malaria Box), and GlaxoSmithKline (GSK) Tres Cantos antimalarial set. All data sets were curated using the “Wash” function implemented in the Molecular Operating Environment (MOE2018.0101) software [64]. The structure of the studied compounds was represented by simplified molecular input line entry system (SMILES) notation, thus obtaining 20,364 unique molecules that are summarized in Table 1. The difference between initial compounds and unique compounds is due to the fact that during the data preparation (curation process), the duplicate compounds are eliminated, those that have positive or negative partial loads have neutralized their protonation states, the metals are disconnected, and the energy is minimized using the molecular mechanistic force field (MMFF94). The result of the data curation is the reduction of the initial number of molecules present in the databases evaluated in this work.
Databases | Initial compounds | Unique compounds | Source |
---|---|---|---|
Natural Products Antimalarial (NPAs) | 1353 | 1312 | Databases of NP in house |
DrugBank Version 5.0. (Drug Antimalarial) | 26 | 4 | https://www.drugbank.ca |
European Bioinformatics Institute. (CHEMBL Drugs Indications) (Antimalarial activities | 27 | 24 | [https://www.ebi.ac.uk/chembl] |
Open Source Drug Discovery (OSDD) Malaria | 93 | 88 | http://opensourcemalaria.org/ |
Malaria Box-Medicine of Malaria Venture (MMV) | 124 | 124 | https://www.ebi.ac.uk/chembl/malaria/source |
St. Jude Children’s Research Hospital’s | 1.478 | 1.478 | https://www.ebi.ac.uk/chemblntd |
Novartis-GNF Malaria Box | 4.878 | 4.868 | Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941073/ Available in: https://www.ebi.ac.uk/chemblntd |
GlaxoSmithKline Tres Cantos Antimalarial | 12.470 | 12.466 | Open Source Malaria (GSK-TCMDC). Available in: https://www.ebi.ac.uk/chemblntd |
Databases analyzed with chemoinformatic tools.
The descriptors of physicochemical properties, hydrogen bond acceptors (HBAs), hydrogen bond donors (HBDs), number of rotatable bonds (NRBs), the octanol/water partition coefficient (logP), topological polar surface area (TPSA), and molecular weight (MW), or others such as molar refractivity, are important physicochemical parameters for quantitative structure-activity relationship (QSAR) analysis. These molecular descriptors are based on Lipinski’s rule and Verger’s rule regarding the prediction of the pharmacological similarity of orally active pharmacological potential [65, 66, 67]. The statistical analysis of the physicochemical properties was realized with RStudio Software 1.0.136 AGPL [68].
PCAs were done with MOE software [64], and the dominant characteristics are expressed as covariance and visualized with the corresponding 2D or 3D graphic score plot with DataWarrior program v. 5.0 [69]. Figures 2–8 showed the distribution of different compounds with antimalarial activities in the chemical spaces.
3D visualization of the chemical space of natural product databases.
3D visualization of the chemical space of synthetic compounds.
3D visualization of the chemical spaces of natural products and GNF DBs.
3D visualization of the chemical spaces of natural products and TCMDC DBs.
3D visualization of the chemical spaces of natural products and DBK DBs.
3D visualization of the chemical spaces of natural products, OSM and St. Jude.
3D visualization of the chemical spaces of all databases.
In Figures 2–8 we observed that NPs, drugs, and synthetic compounds occupy, in general, similar chemical space and are overlapping in most of the evaluated databases.
Three binary molecular fingerprints were calculated with RStudio package rcdk: Extended connectivity fingerprints with diameter 4 (ECFP-4) for similarity searching, molecular access system (MACCS) keys of 166 bits for determining similarity and molecular diversity, and PubChem keys of 881 bits for encoding molecular fragment information [42, 43, 44]. The similarity of fingerprints by structural pairs of compounds was calculated with the Tanimoto coefficient and analyzed with the cumulative distribution function (CDF). This approach has been used to calculate, measure, and represent the molecular variety of compound data sets [23].
Figures 9–11 show the CDFs of the pairwise similarity of the different data sets evaluated with Tanimoto coefficient and ECPF-4, MACCS keys, and PubChem fingerprints, respectively.
Curve for cumulative frequency distribution (CFD) based on ECFP-4.
Curve for cumulative frequency distribution based on MACCS keys.
Curve for cumulative frequency distribution based on PubChem.
Cyclic system retrieval curves for all databases evaluated in this study.
Figures 9–11 provide information on the structural diversity of the six databases. Similar approach has been previously published [23]; the curves obtained with ECFP-4 did not prove to be a suitable fingerprint representation for these data sets. In the three similarity graphs based on fingerprints, it is shown that the database of natural products with antimalarial activity, OMS, and MMV has the lowest molecular diversity, while GSK DB was the most diverse.
In Tables 2–4, the statistical values of the pairwise Tanimoto similarity with the data sets analyzed are shown. In these tables, CHEMBL and DrugBank databases are excluded from our analysis, due to the small amount of data.
Similarity ECFP-4/Tanimoto coefficient | ||||||
---|---|---|---|---|---|---|
DBs | Min. | 1st Qu. | Median | Mean | 3rd Qu. | Max. |
GSK | 0.01724 | 0.05789 | 0.08844 | 0.11490 | 0.12245 | 0.82353 |
NPs | 0.00000 | 0.07826 | 0.09910 | 0.10565 | 0.12389 | 1.00000 |
OSM | 0.00000 | 0.07826 | 0.09917 | 0.10607 | 0.12397 | 1.00000 |
MMV | 0.00000 | 0.07826 | 0.09924 | 0.10615 | 0.12403 | 1.00000 |
ST JUDE | 0.00000 | 0.08197 | 0.10345 | 0.10980 | 0.12857 | 1.00000 |
GNF | 0.00000 | 0.08209 | 0.10345 | 0.10772 | 0.12739 | 1.00000 |
The statistical values of the similarity of the Tanimoto coefficient with ECFP-4.
Similarity MACCS keys/Tanimoto coefficient | ||||||
---|---|---|---|---|---|---|
DBs | Min. | 1st Qu. | Median | Mean | 3rd Qu. | Max. |
GSK | 0.07813 | 0.25682 | 0.33333 | 0.37009 | 0.45581 | 0.92683 |
NPs | 0.00000 | 0.34426 | 0.43636 | 0.44673 | 0.54545 | 1.00000 |
OSM | 0.00000 | 0.34483 | 0.43636 | 0.44693 | 0.54545 | 1.00000 |
MMV | 0.00000 | 0.34483 | 0.43636 | 0.44677 | 0.54412 | 1.00000 |
ST JUDE | 0.00000 | 0.33333 | 0.41250 | 0.42313 | 0.50000 | 1.00000 |
GNF | 0.00000 | 0.31746 | 0.39437 | 0.39999 | 0.47619 | 1.00000 |
The statistical values of the similarity of the Tanimoto coefficient with MACCS keys.
Similarity PubChem/Tanimoto coefficient | ||||||
---|---|---|---|---|---|---|
DBs | Min. | 1st Qu. | Median | Mean | 3rd Qu. | Max. |
GSK | 0.08125 | 0.24500 | 0.37555 | 0.40263 | 0.54002 | 1.00000 |
NPs | 0.03684 | 0.32298 | 0.43802 | 0.46184 | 0.58621 | 1.00000 |
OSM | 0.03684 | 0.32340 | 0.43902 | 0.46253 | 0.58730 | 1.00000 |
MMV | 0.03684 | 0.32444 | 0.44033 | 0.46321 | 0.58791 | 1.00000 |
ST JUDE | 0.03684 | 0.38224 | 0.47143 | 0.47624 | 0.56195 | 1.00000 |
GNF | 0.00000 | 0.40598 | 0.48117 | 0.47800 | 0.55446 | 1.00000 |
The statistical values of the similarity of the Tanimoto coefficient with PubChem.
Murcko scaffolds were calculated with the program Molecular Equivalent Indices (MEQI) [50, 51] and DataWarrior program [69]. MEQI has been used to obtain the codes corresponding to the chemotypes most frequently analyzed in the databases. [23, 45, 52, 53, 54, 55]. The distribution and diversity of the molecular scaffolds present in the data sets were calculated and analyzed using the cyclic system retrieval (CSR) curves [42]. These curves were obtained by plotting the fraction of scaffold and the fraction of compounds that contain cyclic systems [43, 44].
Table 5 indicates that the MMV DB (0.491) was the most diverse in scaffold content taken as reference the F50 values compared to the data set from GSK (0.183), NPs (0.168), and GNF (0.161), respectively. CSR curves on Figure 12 further confirm the relative scaffold variety of the eight databases. The analysis of area under curve (AUC) metrics associated with the CSR curves is reported in Table 5. The CSR curves showed that MMV has more variety in scaffold content with AUC value of 0.507. In contrast OSM, NPs, GNF, GSK, St. Jude, and CHEMBL were the least diverse (e.g., AUC scores of 0.745, 0.712, 0.705, 0.698, 0.655 and 0.607, respectively). The CSR curves provide information on the diversity of the most frequent scaffolds in all databases.
DBs | Number of Compounds (M) | Unique chemotypes (N) | FN/M | NSING | FNSING/M | FNSING/NS | AUC | F50 |
---|---|---|---|---|---|---|---|---|
NPs | 1298 | 629 | 0.4846 | 400 | 0.3082 | 0.6359 | 0.7125 | 0.1685 |
DBK | 5 | 5 | 1.0000 | 5 | 1.0000 | 1.0000 | 0.4800 | 0.4000 |
CHEMBL | 24 | 18 | 0.7500 | 16 | 0.6667 | 0.8889 | 0.6072 | 0.3333 |
OSM | 89 | 39 | 0.4382 | 27 | 0.3034 | 0.6923 | 0.7453 | 0.1025 |
MMV | 124 | 122 | 0.9839 | 120 | 0.9677 | 0.9836 | 0.5079 | 0.4918 |
St. JUDE | 915 | 479 | 0.5235 | 325 | 0.3552 | 0.6785 | 0.6551 | 0.2474 |
GNF | 4860 | 3229 | 0.6644 | 2690 | 0.5535 | 0.8331 | 0.7054 | 0.1615 |
GSK | 12,463 | 6703 | 0.5378 | 5009 | 0.4019 | 0.7473 | 0.6982 | 0.1837 |
Summary of the scaffold diversity of the eight databases analyzed in this work.
M = number of molecules in the BD, N = number of chemotypes or substructures, FN/M = chemotype diversity fraction, NSING = singleton number, FNSING/M = singleton fraction between total molecules, FNSING/N = fraction of singleton among total chemotypes, AUC = area under the curve, F50 = fraction of chemotype required to recover 50% of the molecules.
The Shannon entropy has been adapted to measure the scaffold diversity based on the (
Figure 13 shows a histogram with the distribution of the 40 most populated scaffolds in NPAs. The histogram includes the corresponding chemotype code. The comparison of the scaffolds of the NPAs allowed the identification of the 68MBD chemotype as one of the most active compounds in this database.
Scaled Shannon entropy of the most frequent scaffolds with values ranging from 10 to 40 in natural products.
The structural descriptors used to quantify fraction of sp3 hybridized carbons (Fsp3) [23, 58, 63, 70], fraction of chiral centers (CCF) [23, 59, 63, 70], fraction of aromatic atoms (Faro-atm), globularity [60], principal moments of inertia (PMI), normalized principal moments of inertia ratio (NRP) [61, 62], molecular complexity, shape index of Kier, and molecular flexibility were calculated with DataWarrior program [69] and MOE 2018.0101 [64]. Figures 14–19 showed the descriptors utilized to evaluate the complexity and the molecular flexibility.
Distribution of the fraction of sp3 hybridized carbons in different databases.
Distribution of the fraction of chiral centers in different databases.
Distribution of the fraction of aromatic atoms (Faro-atm) in different databases.
Shape index distribution of different databases.
Distribution of the molecular flexibility in different databases.
Distribution of the molecular complexity in different databases.
Tables 6–8 summarize the statistics of the distribution of Fsp3, FCC, and Faro-atm of NPs and reference data sets. These results indicate that the NP data set has the largest complexity molecular in Fsp3 (0.63) and CCF (0.16) and a low distribution of Faro-atm (0.67–0.78). In contrast, GNF, MMV, St. Jude, and GSK DBs are very similar in these three metrics with values between 0.25 and 0.37, 0.27 and 0.37, and 0.014 and 0.025, respectively. In contrast, the structural flexibility was evaluated with the index of form presenting all databases in the range of 0.41–0.58 indicating that many of the compounds present sphericity and intermediate molecular flexibility (data not presented).
Fraction of sp3 hybridized atoms (Fsp3) | |||||||
---|---|---|---|---|---|---|---|
DBs | Min | 1qst | median | mean | 3qrt | max | dev.st |
NPs | 0.000 | 0.481 | 0.636 | 0.656 | 0.833 | 2.000 | 0.254 |
CHEMBL | 0.167 | 0.342 | 0.536 | 0.621 | 0.627 | 1.333 | 0.374 |
MMV | 0.000 | 0.167 | 0.300 | 0.316 | 0.402 | 0.800 | 0.190 |
OSM | 0.000 | 0.174 | 0.255 | 0.277 | 0.338 | 0.893 | 0.145 |
DBK | 0.250 | 0.438 | 0.519 | 0.463 | 0.545 | 0.565 | 0.175 |
GNF | 0.000 | 0.227 | 0.364 | 0.377 | 0.500 | 2.667 | 0.207 |
STJUDE | 0.000 | 0.222 | 0.333 | 0.353 | 0.471 | 1.136 | 0.178 |
GSK | 0.000 | 0.250 | 0.375 | 0.372 | 0.500 | 1.500 | 0.180 |
Distribution of Fsp3 in different databases.
Fraction of chiral centers (CCF) | |||||||
---|---|---|---|---|---|---|---|
DBs | min | 1qst | median | mean | 3qrt | max | dev.st |
NPs | 0.000 | 0.033 | 0.139 | 0.161 | 0.267 | 0.656 | 0.145 |
CHEMBL | 0.000 | 0.000 | 0.036 | 0.128 | 0.141 | 0.533 | 0.192 |
MMV | 0.000 | 0.000 | 0.000 | 0.014 | 0.000 | 0.111 | 0.028 |
OSM | 0.000 | 0.000 | 0.000 | 0.008 | 0.000 | 0.286 | 0.035 |
DBK | 0.000 | 0.000 | 0.019 | 0.020 | 0.040 | 0.043 | 0.024 |
GNF | 0.000 | 0.000 | 0.000 | 0.025 | 0.040 | 0.556 | 0.053 |
STJUDE | 0.000 | 0.000 | 0.000 | 0.024 | 0.045 | 0.217 | 0.037 |
GSK | 0.000 | 0.000 | 0.000 | 0.017 | 0.034 | 0.500 | 0.033 |
Distribution of FCC in different databases.
Fraction of aromatic atoms (Faro-atm) | |||||||
---|---|---|---|---|---|---|---|
DBs | min | 1qst | median | mean | 3qrt | max | dev.st |
NPs | 0.000 | 0.000 | 0.324 | 0.341 | 0.600 | 1.133 | 0.294 |
CHEMBL | 0.000 | 0.299 | 0.556 | 0.509 | 0.690 | 1.091 | 0.321 |
MMV | 0.261 | 0.682 | 0.826 | 0.817 | 0.956 | 1.429 | 0.230 |
OSM | 0.000 | 0.677 | 0.733 | 0.786 | 0.860 | 1.500 | 0.232 |
DBK | 0.538 | 0.591 | 0.733 | 0.720 | 0.862 | 0.875 | 0.171 |
GNF | 0.000 | 0.522 | 0.667 | 0.670 | 0.818 | 1.714 | 0.235 |
STJUDE | 0.000 | 0.553 | 0.712 | 0.708 | 0.857 | 1.556 | 0.216 |
GSK | 0.000 | 0.571 | 0.706 | 0.713 | 0.857 | 1.400 | 0.208 |
Distribution of fraction of aromatic atoms.
The descriptors globularity, PMI, and NRP did not prove to be suitable metrics to measure and differentiate the molecular complexity in the data sets evaluated. This is because the corresponding values computed for all data sets were very low (close to zero) and did not differentiate the data sets (data not shown). The large molecular complexity of NPs measured is in agreement with previous studies using similar metrics [23, 63, 71].
The methods of modeling the landscape based on properties of the compounds (property landscape modeling (PLM)) is at the interface between experimental sciences and computational chemistry, being a frequent strategy to systematically describe the structure-property relationships (SPR) of the compound data set [72]. PLM have been used in medicinal chemistry in the stages of drug discovery with a quantitative, descriptive, and statistical approach to activity cliffs [72, 73, 74]. Structure-activity relationships (SARs), using the concept of modeling the activity landscape (activity landscape modeling ALM), are an increasing common practice in the drug discovery process to identify the activity cliffs, guide the optimization of compound hits, and to avoid the deleterious effects of the activity cliffs in the studies of the classic models of QSAR and in the search of structural similarity. In this research we analyze, through the web tool Activity Landscape Plotter (ALP) [72], a set of data from NPs from Panama with antimalarial activity against four strains of
Structural similarity compared with activity cliffs in NPAs.
Structural similarity compared with activity cliffs in GSK and Novartis (GNF).
SAS maps of compounds with antimalarial activity ((a), (b), and (c)) through the web tool activity landscape plotter.
DAS map with MACCS key fingerprint.
Antimalarial compounds in NPs from Panama.
The generation and comparison of structure-activity pairs, by structure-activity similarity maps (SAS map). The SAS map has been used to link up structure and biological activity, based on a systematic pairwise comparison of all the compounds in a data set analyzed. We compare the values of structure-activity similarity, the activity difference, and structure-activity landscape index (SALI) to find the pairs of compounds with high molecular similarity and the activity difference that are located in the upper right quadrant of the SAS map (activity cliffs) [72, 73, 74, 75, 76]. Figures 17–21 show SAS map in NP of Panama, NP published, GSK, and GNF. In SAS maps, data points are colored by density (Figure 22).
The SAS maps using the molecular fingerprints EFCP-4, MACCS keys, and PubChem led to the identification of a total of 26 pairs of compounds with structure-activity similarity ratios >0.50 and structure-activity landscape index values varying between 0.3 and 5.0. The web application Activity Landscape Plotter [72] is a tool that allows us to perform QSAR. The SAS generated represent 55 natural products isolated in Panama with antimalarial activity which were analyzed and compared the biological activities against strains of
SAS maps are color-coded according to their intensity and we observe that most pairs of compounds with antimalarial activity show an intense red color. Analyzed are located in the region of little structural similarity, indicating that the natural products have high structural diversity and low difference in activity, attributed to having similar functional groups in their molecules.
DAS maps represent the pairwise activity differences for each possible pair of compounds in an evaluated data set, against two biological targets. These maps permitted to differentiate if a structural modification can increase or decrease the activity under one target or other (Figure 23).
With this web application, we have carried out a QSAR study in a fast, simple, and easily interpretable way, obtaining three natural products as leading computational compounds for their optimization as
The chemoinformatic analysis of the 20,364 compounds (1312 NPs and 19,052 synthetic (MMV, OSM, GNF, St. Jude, GSK, CHEMBL, and DrugBank)) indicates that so many natural products and synthetic products (S) share the same chemical space showing molecules that have similar structural properties. NPs present a greater diversity based on fingerprint than the synthetic compounds. Also, NPs have a higher proportion of chiral carbons and atoms with sp3 hybridization and greater complexity, while synthetic products contain a greater proportion of aromatic atoms. Finally, concerning the properties related to cyclicity, relative shape, and flexibility, all have very similar values, which could explain the antimalarial activity of computationally determined compound hits in this work against
The DAO acknowledges the SNI 2018 awards from SENACYT of Panama.
The authors declare that there are no financial or commercial conflicts of interest.
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Very young children are regular users of smartphones and tablet, so their early digital engagement poses new challenges to parent-child relationships and parental role. First, the chapter introduces the “digital parenting” construct, moving through the literature from “traditional” parenting styles to more recent studies on “parental mediation,” that is, the different behaviors parents adopt to regulate children’s engagement with the Internet and digital media. Second, the chapter reviews empirical researches on different parental mediation practices (active or restrictive behaviors) and how they are adjusted according to the child’s characteristics (age, digital competences, etc.) or parent’s media competence and beliefs. Finally, from a bidirectional perspective of parent-child relationships, the chapter discusses the role of youths’ social involvement, communication, self-disclosure, and digital skills on parent’s beliefs and practices. 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Singh",profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8018",title:"Extracellular Matrix",subtitle:"Developments and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/8018.jpg",slug:"extracellular-matrix-developments-and-therapeutics",publishedDate:"October 27th 2021",editedByType:"Edited by",bookSignature:"Rama Sashank Madhurapantula, Joseph Orgel P.R.O. and Zvi Loewy",hash:"c85e82851e80b40282ff9be99ddf2046",volumeInSeries:23,fullTitle:"Extracellular Matrix - Developments and Therapeutics",editors:[{id:"212416",title:"Dr.",name:"Rama Sashank",middleName:null,surname:"Madhurapantula",slug:"rama-sashank-madhurapantula",fullName:"Rama Sashank Madhurapantula",profilePictureURL:"https://mts.intechopen.com/storage/users/212416/images/system/212416.jpg",institutionString:"Illinois Institute of Technology",institution:{name:"Illinois Institute of Technology",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9759",title:"Vitamin E in Health and Disease",subtitle:"Interactions, Diseases and Health Aspects",coverURL:"https://cdn.intechopen.com/books/images_new/9759.jpg",slug:"vitamin-e-in-health-and-disease-interactions-diseases-and-health-aspects",publishedDate:"October 6th 2021",editedByType:"Edited by",bookSignature:"Pınar Erkekoglu and Júlia Scherer Santos",hash:"6c3ddcc13626110de289b57f2516ac8f",volumeInSeries:22,fullTitle:"Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects",editors:[{id:"109978",title:"Prof.",name:"Pınar",middleName:null,surname:"Erkekoğlu",slug:"pinar-erkekoglu",fullName:"Pınar Erkekoğlu",profilePictureURL:"https://mts.intechopen.com/storage/users/109978/images/system/109978.jpg",institutionString:"Hacettepe University",institution:{name:"Hacettepe University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Proteomics",value:18,count:4},{group:"subseries",caption:"Metabolism",value:17,count:6},{group:"subseries",caption:"Cell and Molecular Biology",value:14,count:9},{group:"subseries",caption:"Chemical Biology",value:15,count:13}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:8},{group:"publicationYear",caption:"2021",value:2021,count:7},{group:"publicationYear",caption:"2020",value:2020,count:12},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:2}],authors:{paginationCount:229,paginationItems:[{id:"318170",title:"Dr.",name:"Aneesa",middleName:null,surname:"Moolla",slug:"aneesa-moolla",fullName:"Aneesa Moolla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/318170/images/system/318170.png",biography:"Dr. Aneesa Moolla has extensive experience in the diverse fields of health care having previously worked in dental private practice, at the Red Cross Flying Doctors association, and in healthcare corporate settings. She is now a lecturer at the University of Witwatersrand, South Africa, and a principal researcher at the Health Economics and Epidemiology Research Office (HE2RO), South Africa. Dr. Moolla holds a Ph.D. in Psychology with her research being focused on mental health and resilience. In her professional work capacity, her research has further expanded into the fields of early childhood development, mental health, the HIV and TB care cascades, as well as COVID. She is also a UNESCO-trained International Bioethics Facilitator.",institutionString:"University of the Witwatersrand",institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419588",title:"Ph.D.",name:"Sergio",middleName:"Alexandre",surname:"Gehrke",slug:"sergio-gehrke",fullName:"Sergio Gehrke",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038WgMKQA0/Profile_Picture_2022-06-02T11:44:20.jpg",biography:"Dr. Sergio Alexandre Gehrke is a doctorate holder in two fields. The first is a Ph.D. in Cellular and Molecular Biology from the Pontificia Catholic University, Porto Alegre, Brazil, in 2010 and the other is an International Ph.D. in Bioengineering from the Universidad Miguel Hernandez, Elche/Alicante, Spain, obtained in 2020. In 2018, he completed a postdoctoral fellowship in Materials Engineering in the NUCLEMAT of the Pontificia Catholic University, Porto Alegre, Brazil. He is currently the Director of the Postgraduate Program in Implantology of the Bioface/UCAM/PgO (Montevideo, Uruguay), Director of the Cathedra of Biotechnology of the Catholic University of Murcia (Murcia, Spain), an Extraordinary Full Professor of the Catholic University of Murcia (Murcia, Spain) as well as the Director of the private center of research Biotecnos – Technology and Science (Montevideo, Uruguay). Applied biomaterials, cellular and molecular biology, and dental implants are among his research interests. He has published several original papers in renowned journals. In addition, he is also a Collaborating Professor in several Postgraduate programs at different universities all over the world.",institutionString:null,institution:{name:"Universidad Católica San Antonio de Murcia",country:{name:"Spain"}}},{id:"342152",title:"Dr.",name:"Santo",middleName:null,surname:"Grace Umesh",slug:"santo-grace-umesh",fullName:"Santo Grace Umesh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/342152/images/16311_n.jpg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"333647",title:"Dr.",name:"Shreya",middleName:null,surname:"Kishore",slug:"shreya-kishore",fullName:"Shreya Kishore",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333647/images/14701_n.jpg",biography:"Dr. Shreya Kishore completed her Bachelor in Dental Surgery in Chettinad Dental College and Research Institute, Chennai, and her Master of Dental Surgery (Orthodontics) in Saveetha Dental College, Chennai. She is also Invisalign certified. She’s working as a Senior Lecturer in the Department of Orthodontics, SRM Dental College since November 2019. She is actively involved in teaching orthodontics to the undergraduates and the postgraduates. Her clinical research topics include new orthodontic brackets, fixed appliances and TADs. She’s published 4 articles in well renowned indexed journals and has a published patency of her own. Her private practice is currently limited to orthodontics and works as a consultant in various clinics.",institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"323731",title:"Prof.",name:"Deepak M.",middleName:"Macchindra",surname:"Vikhe",slug:"deepak-m.-vikhe",fullName:"Deepak M. Vikhe",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/323731/images/13613_n.jpg",biography:"Dr Deepak M.Vikhe .\n\n\t\n\tDr Deepak M.Vikhe , completed his Masters & PhD in Prosthodontics from Rural Dental College, Loni securing third rank in the Pravara Institute of Medical Sciences Deemed University. He was awarded Dr.G.C.DAS Memorial Award for Research on Implants at 39th IPS conference Dubai (U A E).He has two patents under his name. He has received Dr.Saraswati medal award for best research for implant study in 2017.He has received Fully funded scholarship to Spain ,university of Santiago de Compostela. He has completed fellowship in Implantlogy from Noble Biocare. \nHe has attended various conferences and CDE programmes and has national publications to his credit. His field of interest is in Implant supported prosthesis. Presently he is working as a associate professor in the Dept of Prosthodontics, Rural Dental College, Loni and maintains a successful private practice specialising in Implantology at Rahata.\n\nEmail: drdeepak_mvikhe@yahoo.com..................",institutionString:null,institution:{name:"Pravara Institute of Medical Sciences",country:{name:"India"}}},{id:"204110",title:"Dr.",name:"Ahmed A.",middleName:null,surname:"Madfa",slug:"ahmed-a.-madfa",fullName:"Ahmed A. Madfa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204110/images/system/204110.jpg",biography:"Dr. Madfa is currently Associate Professor of Endodontics at Thamar University and a visiting lecturer at Sana'a University and University of Sciences and Technology. He has more than 6 years of experience in teaching. His research interests include root canal morphology, functionally graded concept, dental biomaterials, epidemiology and dental education, biomimetic restoration, finite element analysis and endodontic regeneration. Dr. Madfa has numerous international publications, full articles, two patents, a book and a book chapter. Furthermore, he won 14 international scientific awards. Furthermore, he is involved in many academic activities ranging from editorial board member, reviewer for many international journals and postgraduate students' supervisor. Besides, I deliver many courses and training workshops at various scientific events. Dr. Madfa also regularly attends international conferences and holds administrative positions (Deputy Dean of the Faculty for Students’ & Academic Affairs and Deputy Head of Research Unit).",institutionString:"Thamar University",institution:null},{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",biography:"Dr. Nermin Mohammed Ahmed Yussif is working at the Faculty of dentistry, University for October university for modern sciences and arts (MSA). Her areas of expertise include: periodontology, dental laserology, oral implantology, periodontal plastic surgeries, oral mesotherapy, nutrition, dental pharmacology. She is an editor and reviewer in numerous international journals.",institutionString:"MSA University",institution:null},{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",country:{name:"India"}}},{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null},{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178412/images/6954_n.jpg",biography:"Assoc. Prof. Dr. Gühan Dergin was born in 1973 in Izmit. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry and obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Dergin still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. He has many articles in international and national scientific journals and chapters in books.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178414/images/6953_n.jpg",biography:"Born in Istanbul in 1974, Dr. Emes graduated from Istanbul University Faculty of Dentistry in 1997 and completed his PhD degree in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery in 2005. He has papers published in international and national scientific journals, including research articles on implantology, oroantral fistulas, odontogenic cysts, and temporomandibular disorders. Dr. Emes is currently working as a full-time academic staff in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery.",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"192229",title:"Ph.D.",name:"Ana Luiza",middleName:null,surname:"De Carvalho Felippini",slug:"ana-luiza-de-carvalho-felippini",fullName:"Ana Luiza De Carvalho Felippini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192229/images/system/192229.jpg",biography:null,institutionString:"University of São Paulo",institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256851/images/9696_n.jpg",biography:"Dr. Ayşe Gülşen graduated in 1990 from Faculty of Dentistry, University of Ankara and did a postgraduate program at University of Gazi. \nShe worked as an observer and research assistant in Craniofacial Surgery Departments in New York, Providence Hospital in Michigan and Chang Gung Memorial Hospital in Taiwan. \nShe works as Craniofacial Orthodontist in Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi, Ankara Turkey since 2004.",institutionString:"Univeristy of Gazi",institution:null},{id:"255366",title:"Prof.",name:"Tosun",middleName:null,surname:"Tosun",slug:"tosun-tosun",fullName:"Tosun Tosun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255366/images/7347_n.jpg",biography:"Graduated at the Faculty of Dentistry, University of Istanbul, Turkey in 1989;\nVisitor Assistant at the University of Padua, Italy and Branemark Osseointegration Center of Treviso, Italy between 1993-94;\nPhD thesis on oral implantology in University of Istanbul and was awarded the academic title “Dr.med.dent.”, 1997;\nHe was awarded the academic title “Doç.Dr.” (Associated Professor) in 2003;\nProficiency in Botulinum Toxin Applications, Reading-UK in 2009;\nMastership, RWTH Certificate in Laser Therapy in Dentistry, AALZ-Aachen University, Germany 2009-11;\nMaster of Science (MSc) in Laser Dentistry, University of Genoa, Italy 2013-14.\n\nDr.Tosun worked as Research Assistant in the Department of Oral Implantology, Faculty of Dentistry, University of Istanbul between 1990-2002. \nHe worked part-time as Consultant surgeon in Harvard Medical International Hospitals and John Hopkins Medicine, Istanbul between years 2007-09.\u2028He was contract Professor in the Department of Surgical and Diagnostic Sciences (DI.S.C.), Medical School, University of Genova, Italy between years 2011-16. \nSince 2015 he is visiting Professor at Medical School, University of Plovdiv, Bulgaria. \nCurrently he is Associated Prof.Dr. at the Dental School, Oral Surgery Dept., Istanbul Aydin University and since 2003 he works in his own private clinic in Istanbul, Turkey.\u2028\nDr.Tosun is reviewer in journal ‘Laser in Medical Sciences’, reviewer in journal ‘Folia Medica\\', a Fellow of the International Team for Implantology, Clinical Lecturer of DGZI German Association of Oral Implantology, Expert Lecturer of Laser&Health Academy, Country Representative of World Federation for Laser Dentistry, member of European Federation of Periodontology, member of Academy of Laser Dentistry. Dr.Tosun presents papers in international and national congresses and has scientific publications in international and national journals. He speaks english, spanish, italian and french.",institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"256417",title:"Associate Prof.",name:"Sanaz",middleName:null,surname:"Sadry",slug:"sanaz-sadry",fullName:"Sanaz Sadry",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256417/images/8106_n.jpg",biography:null,institutionString:null,institution:null},{id:"272237",title:"Dr.",name:"Pinar",middleName:"Kiymet",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272237/images/8911_n.png",biography:"Assist.Prof.Dr.Pınar Kıymet Karataban, DDS PhD \n\nDr.Pınar Kıymet Karataban was born in Istanbul in 1975. After her graduation from Marmara University Faculty of Dentistry in 1998 she started her PhD in Paediatric Dentistry focused on children with special needs; mainly children with Cerebral Palsy. She finished her pHD thesis entitled \\'Investigation of occlusion via cast analysis and evaluation of dental caries prevalance, periodontal status and muscle dysfunctions in children with cerebral palsy” in 2008. She got her Assist. Proffessor degree in Istanbul Aydın University Paediatric Dentistry Department in 2015-2018. ın 2019 she started her new career in Bahcesehir University, Istanbul as Head of Department of Pediatric Dentistry. In 2020 she was accepted to BAU International University, Batumi as Professor of Pediatric Dentistry. She’s a lecturer in the same university meanwhile working part-time in private practice in Ege Dental Studio (https://www.egedisklinigi.com/) a multidisciplinary dental clinic in Istanbul. Her main interests are paleodontology, ancient and contemporary dentistry, oral microbiology, cerebral palsy and special care dentistry. She has national and international publications, scientific reports and is a member of IAPO (International Association for Paleodontology), IADH (International Association of Disability and Oral Health) and EAPD (European Association of Pediatric Dentistry).",institutionString:null,institution:null},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202198/images/6955_n.jpg",biography:"Buket Aybar, DDS, PhD, was born in 1971. She graduated from Istanbul University, Faculty of Dentistry, in 1992 and completed her PhD degree on Oral and Maxillofacial Surgery in Istanbul University in 1997.\nDr. Aybar is currently a full-time professor in Istanbul University, Faculty of Dentistry Department of Oral and Maxillofacial Surgery. She has teaching responsibilities in graduate and postgraduate programs. Her clinical practice includes mainly dentoalveolar surgery.\nHer topics of interest are biomaterials science and cell culture studies. She has many articles in international and national scientific journals and chapters in books; she also has participated in several scientific projects supported by Istanbul University Research fund.",institutionString:null,institution:null},{id:"260116",title:"Dr.",name:"Mehmet",middleName:null,surname:"Yaltirik",slug:"mehmet-yaltirik",fullName:"Mehmet Yaltirik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/260116/images/7413_n.jpg",biography:"Birth Date 25.09.1965\r\nBirth Place Adana- Turkey\r\nSex Male\r\nMarrial Status Bachelor\r\nDriving License Acquired\r\nMother Tongue Turkish\r\n\r\nAddress:\r\nWork:University of Istanbul,Faculty of Dentistry, Department of Oral Surgery and Oral Medicine 34093 Capa,Istanbul- TURKIYE",institutionString:null,institution:null},{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/172009/images/7122_n.jpg",biography:"Dr. Deniz Uzuner was born in 1969 in Kocaeli-TURKEY. After graduating from TED Ankara College in 1986, she attended the Hacettepe University, Faculty of Dentistry in Ankara. \nIn 1993 she attended the Gazi University, Faculty of Dentistry, Department of Orthodontics for her PhD education. After finishing the PhD education, she worked as orthodontist in Ankara Dental Hospital under the Turkish Government, Ministry of Health and in a special Orthodontic Clinic till 2011. Between 2011 and 2016, Dr. Deniz Uzuner worked as a specialist in the Department of Orthodontics, Faculty of Dentistry, Gazi University in Ankara/Turkey. In 2016, she was appointed associate professor. Dr. Deniz Uzuner has authored 23 Journal Papers, 3 Book Chapters and has had 39 oral/poster presentations. She is a member of the Turkish Orthodontic Society. 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