The transform modes in several video-coding standards [41].
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
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Among some block-based transforms, the discrete cosine transform (DCT) [1] and integer transforms have extensively been used to still image and video-coding specifications, such as JPEG [2], MPEG-1/2 [3, 4], MPEG-4 [5], H.264/AVC [6, 7], AVS [8, 9], VC-1 [10], VP8 [11], and HEVC [12]. Because integer transforms perform the low complexity and effective coding performance, the advanced video coding (AVC) in ITU-T H.264 [6, 7, 13, 14], which is also known as MPEG-4 part 10, applies integer transforms for transform process. The 4 × 4 and 8 × 8 transforms in [13, 14] were calculated exactly to prevent non-adaptation issues of inverse transforms for high-quality moving visual images. The VC-1 specification [10, 15, 16] employed 4 × 4 and 8 × 8 integer transforms, and it was developed by Microsoft Corporation and standardized by the Society of Motion Picture and Television Engineers (SMPTE). The 8 × 8 integer transform is utilized to obtain the high-coding performance in the Audio Video Coding Standard (AVS) for China [8, 9]. In [11], the VP8 video-coding standard was developed for Internet browser applications. The Joint Collaborative Team on Video Coding proposed the high-efficiency video coding (HEVC) specification [12]. By HEVC, the compression efficiency was greatly better than that achieved using the H.264/AVC high-profile-coding specification.
\nTo support the single-standard H.264/AVC video coding, several transform architectures in [17–24] have been developed to approach the multiple transform modes in H.264. To support the single-standard H.265/HEVC video coding, several transform architectures in [25–32] have been developed to approach the multiple transform modes in HEVC. Besides, supporting multiple-standard functions in video coding has been an important issue in multimedia applications recently, such as H.264/AVC, MPEG-1/2/4, VC-1, AVS, and VP8 standards, and several transform architectures in [33–41] have also been developed to complete the multiple transform functions. Owing to the growth of multistandard video-coding applications, how to achieve low-computational complexities and implement by hardware-sharing-based cost-effective architectures simultaneously are interesting research topics for the VLSI design of video codecs.
\nBased on the resemblance property, the 8 × 8 inverse integer transforms [41] in H.264/AVC, AVS, VC-1, VP8, MPEG-1/2/4, and HEVC specifications are revealed in Eq. (1), and Table 1 depicts the coefficient values in the transforms.
\nTransform sizes | \nVC-1 | \nAVS | \nVP8 | \nMPEG-1/2/4 | \nH.264/AVC | \nHEVC | \n
---|---|---|---|---|---|---|
4 × 4 | \n√ | \n√ | \n√ | \nN/A | \n√ | \n√ | \n
8 × 8 | \n√ | \n√ | \nN/A | \n√ | \n√ | \n√ | \n
16 × 16 | \nN/A | \nN/A | \nN/A | \nN/A | \nN/A | \n√ | \n
32 × 32 | \nN/A | \nN/A | \nN/A | \nN/A | \nN/A | \n√ | \n
The transform modes in several video-coding standards [41].
In Eq. (1), it is decomposed by Eq. (2) as
\nIn Eq. (2),
Thus
\nand
In (3), “⊕ “ is the direct sum operator, and the two diagonal blocks
By Eq. (1), for VC-1 the values of the coefficient set {
The general 4 × 4 inverse integer transform matrices [41] can be presented in Eq. (5) as
\nBy Eq. (5), for VC-1 the values of the coefficient set {h, i, j} are {17, 22, 10}, and those for VP8 are {128, 167, 70}. Next, those for AVS-M are {2, 3, 1}, and those for H.264/AVC are {1, 1, 0.5}. Finally, those for HEVC are {64, 83, 36}.
\nThe one-dimensional (1D) 32 × 32 inverse core transform for HEVC is described in [30]. By the symmetrical property, the 32 × 32 inverse core transform is presented as
\nwhere
By Eqs. (6) and (7),
where
where “⊕” means the direct sum operation, and then
where the permutation matrix
First, the lower half of
Second, the coefficients in a single column vector can be shared. The vector coefficient computations are achieved by integrating several base coefficients [32]. After realizing the column vectors of
Adder tree structures are utilized to calculate the aggregate results for the row vectors
where
where
The 16 × 16 integer core transform in [30] changes into
\nwhere
where
In Eq. (18),
and
where
By the duplicate processed of
where
where
where
where
The 8 × 8 integer transform in [30] is described as
\nwhere
where
In Eq. (27),
where
In Eq. (28),
where
where
where
In Eq. (32), the computations of
The 4 × 4 integer core transform matrix is indicated as
\nwhere
where
In Eq. (34),
In Eq. (36),
where
where
By the abovementioned discussions, the hardware modules of 4 × 4, 8 × 8, and 16 × 16 inverse core transforms are shared to implement
Next, the hardware-sharing-based 16-point inverse transform is described as
\nFinally, the hardware-sharing-based 32-point inverse transform is depicted as
\nIn this section, the hardware-sharing transform architecture cuts down the hardware cost because the same submodules and coefficients of the transforms are extracted to be shared. Figure 1 illustrates the architecture of the hardware-sharing-based inverse core transform design for 4 × 4/8 × 8/16 × 16/32 × 32 transforms [32].
\nThe proposed 1D inverse core transform in [32] involves four inputs to sustain 4 × 4, 8 × 8, 16 × 16, and 32 × 32 transform modes. Several multiplexers are utilized to acquire the transform outputs of the 32 × 32 inverse core transform by the shared design of 4 × 4, 8 × 8, and 16 × 16 inverse core transforms [32]. Table 2 lists the number of adders and shifters needed to calculate four modes of the 1D inverse core transform for HEVC. The developed architecture in [32] does not require any multiplier, and the fixed-coefficient multiplications are replaced with simple additions and shift operations. Table 3 shows the comparison of three 16-point inverse transform designs. Compared with the previous works in [29] and [31], the applied architecture contains fewer adders. However, several more shifters are required. Compared with the cost of adders, the shifters need lower hardware expense. Thus, the used architecture decreases the hardware cost more efficiently than previous transform schemes do.
\nThe hardware-sharing-based inverse core transform structure for HEVC.
Transform sizes | \n32 × 32 | \n16 × 16 | \n8 × 8 | \n4 × 4 | \n
---|---|---|---|---|
No. of shifters | \n256 | \n93 | \n40 | \n11 | \n
No. of adders | \n461 | \n146 | \n64 | \n10 | \n
The 1D inverse transform architecture at different transform modes [32].
For H.264/AVC, the transform matrix is employed as a foundation matrix for the multistandard hardware-sharing scheme. Based on Eq. (3), the cost of the upper diagonal matrix in Eq. (43) is eight adders and two shifters.
\nwhere
where
where and
where
where
By Eq. (3), on the other side, the down diagonal matrix
where
For AVS, the
where
For VC-1, the
where
where
For AVS-M, the matrix
where
where
where
The applied hardware-sharing-based 1D multistandard inverse integer transform scheme has two inputs, which sustain 4 × 4 and 8 × 8 transform modes. The hardware blocks of processing the 4 × 4 inverse transforms are shared with that of the upper diagonal matrix
Different 1D inverse integer transform modes | \nNo. of adders | \nNo. of shifters | \n
---|---|---|
Individual designs without hardware shares | \n336 | \n180 | \n
Hardware-sharing-based design in Section 4 | \n82 | \n90 | \n
Hardware comparison between two architectures [41].
To implement the discussed architecture, a cell-based VLSI design flow is utilized to design, simulate, and verify the cost-effective hardware-sharing architecture. For fair comparisons among different transform structures, the normalized mode gain, which is required to normalize the gate counts, is described as follows: By matrix dimensions and without missing generality [40], the normalized mode gains defined for the 32 × 32, 16 × 16, 8 × 8, and 4 × 4 inverse integer transform matrices are 16, 4, 1, and 1/4, respectively.
\nThe hardware-sharing-based design in Section 3 supports 4 × 4, 8 × 8, 16 × 16, and 32 × 32 inverse transform modes for HEVC. Thus, the normalized mode gain of the design is 21.25 (i.e., 16 + 4 + 1 + 0.25). Similarly, five 8 × 8 and five 4 × 4 inverse transform functions are provided by the hardware-shared design in Section 4. Therefore, the normalized mode gain is assigned by 6.25 (i.e., 5 + 1.25) [41]. Afterwards, the normalized gate counts are defined by [40, 41]\n
Table 5 shows the hardware cost comparisons among different 1D multiple transform architectures, which includes single-standard multiple-mode [32] and multiple-standard multiple-mode [41] transform designs.
\nArchitecture | \nAhmed et al. [29] | \nShen et. al. [26] | \nMartuza et. al. [28] | \nQi et al. [36] | \nWang et al. [38] | \n||
---|---|---|---|---|---|---|---|
Gate counts | \n144.8K | \n115.7 K | \n134.8 K | \n39.4 K | \n18 K | \n23.06 K | \n27.4 K | \n
Normalized mode gain | \n21.25 | \n21.25 | \n25.75 | \n5 | \n3.5 | \n4.5 | \n6.25 | \n
Normalized gate counts | \n6.81 K | \n5.44 K | \n5.23 K | \n7.88 K | \n5.14 K | \n5.12 K | \n4.38 K | \n
Supporting modes | \nSingle-standard Multiple-mode | \nSingle-standard Multiple-mode | \nMultiple- standard Multiple- mode | \nMultiple-standard Multiple-mode | \nMultiple-standard Multiple- mode | \nMultiple- standard Multiple- mode | \nMultiple-standard Multiple-mode | \n
Supporting standards/Transforms | \n4 × 4, 8 × 8, 16 × 16, 32 × 32 modes | \n4 × 4, 8 × 8, 16 × 16, 32 × 32 modes | \n4 × 4,8 × 8 modes mode; 8 × 8, 16 × 16, 32 × 32 modes | \n4 × 4, 8 × 8 modes | \n4 × 4, 8 × 8 modes; 8 × 8 mode | \n4 × 4, 8 × 8 modes; 8 × 8 mode | \n4 × 4, 8 × 8 modes; | \n
For the single-standard multiple-mode transform design, this chapter discussed the 4 × 4, 8 × 8, 16 × 16, and 32 × 32 inverse core transforms in HEVC with a cost-effective and hardware-efficient design. By the symmetrical characteristics of the elements, the core transform matrices were factorized into several submatrices. Thus, the hardware of the (
For the multiple-standard multiple-mode transform design, this chapter also discussed the fast algorithm and hardware-sharing-based design of 4 × 4 and/or 8 × 8 inverse transforms among H.264/AVC, VC-1, HEVC, MPEG-1/2/4, AVS, and VP8 for multistandard video decoders. By only shifters and adders, the decomposition scheme of matrices was used to develop the hardware-shared scheme. The used structure in Section 4 decreased the number of shifters and adders by 50 and 75% more than the individual fast algorithm-based implementation did. Besides, for VLSI implementation, the design in Section 4 requires less normalized gate counts than the designs do in [26, 28, 36, 38].
\nThis work was supported by Ministry of Science and Technology, Taiwan, R.O.C. under Grant MOST 105-2221-E-005-078.
Compartment syndrome is defined as an elevated pressure of an anatomical compartment up to a level where the tissue blood perfusion is impeded. Acute compartment syndrome (ACS) of the hand is rare, as compared to other areas of the human body, but the consequences are detrimental if treated suboptimally. Severe functional disability of the hand, due to muscles’ contractures, is the inevitable result of a neglected compartment syndrome. Diagnosis of this urgent situation is challenging and it is based mainly on the clinical examination [1, 2, 3].
In case there is any doubt towards the diagnosis of ACS or for insensate patients, intracompartmental pressure measurement is used to aid the evaluation [4]. Good knowledge of the special anatomy of the hand is necessary, in order to manage compartment syndrome appropriately. Disproportionate pain, severe swelling and a relevant mechanism should raise a strong suspicion of a compartment syndrome [5]. Once the diagnosis of an ACS is made, treatment should be implemented promptly. Intervention varies from simple actions, such as splitting a tight cast, to a surgical decompression [2]. Correct timing of fasciotomies is of paramount importance, in order to achieve a good functional outcome [6].
This chapter aims to present the current concepts regarding hand compartment syndrome. Special features of the hand compartments’ anatomy are reported. Pathophysiology is described briefly, as it is analyzed in extension in other parts of this book. Etiology, diagnosis, treatment and complications are mentioned as well, emphasizing towards the proper technique of fasciotomies.
Hand contains basically ten myofascial compartments: the adductor pollicis compartment, four dorsal interossei and three palmar interossei compartments, the thenar and the hypothenar compartment. The thenar compartment includes the Abductor Pollicis Brevis (AbPB), the Flexor Pollicis Brevis (FPB) and the Opponens Pollicis (OP) muscles. They are innervated by the recurrent motor branch of the median nerve, apart from the deep head of the FPB, which is innervated by the deep branch of the ulnar nerve [2]. The hypothenar compartment includes the Opponens Digiti Minimi (ODM), the Abductor Digiti Minimi (AbDM) and Flexor Digiti Minimi (FDM) muscles. They are all innervated by branches of the ulnar nerve (Figure 1). Although located basically in the wrist, the carpal tunnel is frequently mentioned as a compartment of the hand. Cleland and Grayson ligaments also compartmentalize digital space. All compartments of the hand along with their muscles and nerves are presented on the Table 1 [2, 4, 7]. It is highlighted here that the compartments of the hand contain predominantly motor nerves. Intracompartmental sensory nerves of the hand are only the digital nerves and the median nerve inside the carpal tunnel. This characteristic anatomy is reflected to the clinical image of the compartment syndrome of the hand [4, 5, 8].
Hand compartments cross sectional anatomy. (from: Reichman EF. Compartment syndrome of the hand: A little thought about diagnosis. Case rep Emerg med. 2016;2016 [
Compartment | Muscles | Nerves | Incision |
---|---|---|---|
Adductor Pollicis | Adductor Pollicis | Sensory: None Motor: Branches of the ulnar nerve | Dorsal over the second metacarpal (radial aspect) |
Interossei compartments | 4 dorsal interossei, 3 palmar interossei | Sensory: None Motor: Branches of the ulnar nerve | Two Dorsal incsions over the second and fourth metacarpal |
Thenar | AbPB, OP, FPB | Sensory: None Motor: Recurrent motor branch of the median nerve, apart from the deep head of the FBP (ulnar nerve) | Radial aspect of the first metacarpal |
Hypothenar | AbDM, FDM, ODM | Sensory: None Motor: Ulnar nerve | Ulnar aspect of the fifth metacarpal |
Carpal tunnel | None (FPL, 4 FDS, 4 FDP tendons/not muscles) | Sensory: Median nerve Motor: Recurrent motor branch of the median nerve | Midpalmar incision |
Digital | None (digital tendons/not muscles) | Sensory: digital nerves Motor: None | Lateral midaxial incision |
Compartments of the hand.
AbPB: abductor pollicis brevis, OP: opponens pollicis, FPB: flexor pollicis brevis, AbDM: abductor digiti minimi, FDM: flexor digiti minimi, ODM: opponens digiti minimi, FPL: flexor pollicis longus, FDS: flexor digitorum superficialis, FDP: flexor digitorum profoundis.
Several variations of the hand compartments have been described. Difelice et al. [7] found that in 52% of the hands, the thenar space is separated in two discrete compartments. In 76% of the hands the hypothenar demonstrated at least two compartments. The second, third and fourth interossei group demonstrated different dorsal and volar compartment in the 48%, 67% and 38% of the hands respectively. The fasciotomies used for the treatment of hand ACS are designed based on this anatomic model. Whether further subcompartmentalization of the thenar and hypothenar area has any clinical significance is controversial. Gyuton et al. [9] found through a cadaveric study that fascia between dorsal and volar interrossei muscles subsides at pressures as low as 15 mmHg, putting its clinical relevance in question.
The pathophysiology of acute compartment syndrome is based on Matsen’s arteriovenous gradient theory. According to this model, interstitial edema increases the local venous pressure (Pv). Local blood flow (LBF) equals to arteriovenous pressure difference (Pa - Pv), divided by vascular resistance (R). Thus, the increase of the local venous pressure decreases local blood flow. Tissue ischemia increases small vessels permeability as well as extravascular osmolality, leading to a further fluid extravasation and subsequent more interstitial edema. Viscious cycle is continued through the former mechanism. Local and systemic inflammatory response is exacerbated by the release of cytokines, as a result of impaired tissue blood supply [4, 10].
Muscle damage due to compartment syndrome occurs prior to nerve impairment and it is reversible for the first 4 hours. The time frame after which muscle necrosis is occurred is still controversial, with a reported range among studies between 8 to 12 hours [2, 4, 11]. Experimental studies of canine model showed permanent tissue necrosis and nerve conduction arrest with interstitial pressures of more than 40 mmHg for at least 8 hours [12].
Intracompartmental pressure increases by either extrinsic or intrinsic causes or combination of both. Tight dressings or casts represent extrinsic factors, via external pressure application to the compartments of the hand [13].
Intrinsic causes of hand compartment syndrome are:
Trauma: fractures, soft tissue injury, crush syndrome (Figure 2),
Burns,
High pressure injection injuries (Figure 3),
Iatrogenic: arterial injury, reperfusion surgery, intravenous material extravasation (Figure 4),
Infection: abscess, septic tenosynovitis, necrotizing fasciitis,
Bites (snake, insect),
Anticoagulation medications,
Hand crush syndrome. Compartment syndrome due to extensive soft tissue injury and concomitant third and fourth metacarpal fractures, after prolonged compression of the hand by a heavy object.
Index finger compartment syndrome (delayed presentation), due to high pressure injection injury, complicated with septic tenosynovitis.
Hand compartment syndrome due to extravasation contrast material. Hand is sitting in intrinsic minus position. Excessive swelling and skin blisters are noticed (from: Stavrakakis IM et al. hand compartment syndrome as a result of intravenous contrast extravasation. Oxf med case rep. 2018;2018(12):omy098 [
Patient’s history, clinical image and physical examination are the keystones for the diagnosis of acute compartment syndrome [2]. Localized swelling and disproportionate pain, unresponsive to analgesics, along with a relative mechanism of injury should raise the suspicion of ACS [2, 4, 13]. As mentioned in the anatomy section, sensory nerves of the hand are located outside the compartments, with the exception of the median and digital nerves. Hence, tingling and paresthesia are not always present, unless the carpal tunnel or digits are involved [4, 5].
Serial clinical examination is of paramount importance, in order to detect ACS early. On inspection, severe swelling is noticed. Blisters might also be visible. The hand is sitting in intrinsic minus position, i.e. the metacarpophalangeal joints (MCPJs) are in extension and the interphalangeal joints (IPJs) are in slight flexion (Figure 4) [1, 4, 8]. Digital palpation reveals great tension of the hand. Pain on passive stretching of the intracompartmental muscles is an early sign of impaired blood perfusion. Specifically for the hand, each compartment should be stretched individually. The interossei compartments are stretched by passively abducting and adducting the digits and at the same time keeping the MCPJs in flexion and the IPJs in extension (bring the hand from the intrinsic minus position to the intrinsic plus position - “intrinsic stretch test”). The lumbricals are stretched by passively extending the MCPJ and flexing the proximal IPJ. The adductor pollicis is checked by passively abducting the thumb. Passive adduction of the thumb is used to test the thenar compartment and finally the hypothenar compartment is evaluated by passive adduction and extension of the small finger [2, 13]. In case the five P’s of tissue ischemia are already present (pain, pallor, pulselessness, paresthesia and paralysis), then the diagnosis is considered delayed and irreversible muscle damage is very likely. Clinical examination has high specificity as well as high negative predictive value, meaning that it can exclude ACS better than confirming it [15].
In case there is any doubt regarding the diagnosis of ACS after clinical examination, or for unconscious patients, more subjective tools for evaluation should be used. Intracompartmental pressure measurement (ICP) is considered to be the main adjunct to the diagnosis. It is generally accepted that a pressure difference (ΔP) between the diastolic blood pressure (Pd) and the compartmental pressure (Pc) less than 30 mmHg necessitates surgical decompression (ΔP = Pd – Pc < 30 mmHg). This difference is more reliable than an absolute intracompartmental pressure of more than 30 mmHg [15, 16]. Several modalities of measuring the pressure of the compartments have been described, such as the infusion Whiteside apparatus, the slit catheter technique and the handheld intracompartmental pressure monitoring [13]. Straight catheters have the least accuracy as compared to the slit catheter and side port needle. It is also reported that the Whiteside apparatus overestimates the intracompartmental pressure, which can potentially lead to an unnecessary fasciotomy [2, 15]. Current trend is towards a continuous pressure measurement, which is probably more reliable than a single one, as the latter approach is associated with a high false positive rate [17, 18]. As there are cases of silent compartment syndrome described in the literature, i.e. severe swelling with no excruciating pain, whenever there is a slight suspicion of ACS, ICP measurement should be performed [18].
Regardless of the apparatus used, it is crucial that a correct technique of pressure measurement is performed. General guidelines include perpendicular insertion of the needle on the skin [2], within 5 cm of the fracture site, but not in direct cοntact with the fracture [15, 16]. Particularly for the hand, each compartment’s pressure should be measured individually. The hand should rest at the level of the heart. For the thenar and hypothenar compartment the needle is inserted at the border of glabrous and nonglabrous skin. The adductor pollicis muscle is entered ulnarly to the first metacarpal. The interossei compartments are entered between the index-long, long-ring and ring-small finger metacarpal, 1 cm proximal to the metacarpal heads, superficial at first for the dorsal interrosei muscle and then 0,5 to 1 cm deeper for the volar interrosei. Needle insertion over the midpalmar lesion is also used for carpal tunnel pressure measurement (Figure 5) [2, 4].
Portals of intracompartmental pressure measurement of the hand.
Given the fact that clinical examination and intracompartmental pressure measurements have their own limitations, recent research is directed towards hemodynamic and metabolic parameters in an effort to achieve a more accurate diagnosis of ACS. These parameters include: a. Monitoring local oxygenation (via intramuscular partial oxygen pressure, oxygen saturation measurement or near infrared spectroscopy), b. monitoring local perfusion (via pulsed phased - locked loop ultrasound, photoplethysmography, laser Doppler flowmetry and scintigraphy), c. local metabolic analysis (intramuscular glucose monitoring, intramuscular pH monitoring) and d. serum biomarkers (white blood cell count, erythrocyte sedimentation rate, C - reative protein and creatinine kinase). However there is still no evidence of superiority over intracompartmental pressure measurement and there is still long way to go until they can be used safely in clinical practise [16].
Chronic exertional compartment syndrome is defined as a muscle dysfunction because of ICP rising due to excessive activity. Only few cases of chronic compartment syndrome located in the hand have been described in the literature and the most commonly affected compartments are the adductor pollicis, the first dorsal interosseous, the thenar and hypothenar compartments [19].
Muscles can tolerate a condition of reduced vascular supply for a time period of no more than 6 to 8 hours. Regarding the limbs there is evidence supporting that the time threshold after which necrosis occurs, is 8 hours [6]. There are though case series reporting a good outcome from fasciotomies which were performed within 12 hours [11]. Impeded compartment syndrome should be recognized early, in order to avoid loss of limb function. Once the diagnosis is made, every effort should be done to decrease the intracompartmental pressure. Conservative treatment includes simple releasing of dressings or splitting a tight cast. The hand should be elevated at the level of the heart, but not above it, in order to preserve the arteriovenous gradient. Oxygen supplementation, intravenous hydration and mannitol adminstration are additional adjuvants to operative treatment [10]. Surgical decompression through fasciotomies is the mainstay of treatment, if acute compartment syndrome is suspected [3, 13].
Faciotomies of the hand are performed through four skin incision. a. Two dorsal incisions over the second and the fourth metacarpal are recommended for decompression of the interossei’s and adductor pollicis’ compartments. Blunt dissection is carried out deeper through the fascia between the 1st dorsal interossei and the adductor pollicis and between the dorsal and palmar interossei muscles. b. One incision radial to the first metacarpal between the glabrous and nonglabrous skin for the thenar decompression. c. One incision ulnar to the fifth metacarpal for the hypothenar release. d. Carpal tunnel, although not a true compartment, it should be released through the traditional midpalmar longitudinal incision (Figure 6) [2, 3, 4]. e. If digits are involved, Cleland and Grayson ligaments are released through midaxial lateral incision, 4 cm long centered over the proximal interphallangeal joint (PIPJ), taking care of the neurovascular bundle. Dominant sensory nerves should be avoided, indicating a radial incision for the thumb and the small finger and ulnar incision for the index, middle and ring fingers [2, 13]. In delayed cases though, especially if they are complicated with infection, a volar Brunner incision is suggested (Figure 7). After the procedure, the wounds are generally left opened and the hand is splinted in a safe position of function. In case of severe skin damage (burns), which precludes the splint application, the metacarpophallangeal (MTPJ) joints are pinned in flexion and the PIPJs in extension (intrinsic plus position) [2, 4]. The wounds are inspected every 2 to 3 days and a second debridement is suggested, if signs of infection or necrosis are identified. As soon as edema subsides and circulation is restored, the wounds can either be closed primarily or they can receive a split thickness graft. Priority is given to the coverage of tendons and nerves. Physiotherapy is initiated as early as possible [2, 10]. Proposed treatment algorithm of acute hand compartment syndrome is presented on the Table 2.
Hand fasciotomies. Two dorsal incisions over the second and fourth metacarpal are used to decompress the adductor pollicis and interossei compartments. One incision radial and palmar to the first metacarpal for the thenar compartment. One incision ulnar to the fifth metacarpal for the hypothenar compartment. One midpalmar incision for carpal tunnel release. (from: Stavrakakis IM et al. hand compartment syndrome as a result of intravenous contrast extravasation. Oxf med case rep. 2018;2018(12):omy098 [
Surgical decompression of index finger’s compartment syndrome, due to high pressure injection injury, complicated with septic tenosynovitis of the patient of the
Algorithm of hand ACS management. ΔP: pressure difference, BPd: diastolic blood pressure, ICP: intracompartmental pressure.
A good functional outcome can be expected after ACS, if surgical release is performed early. In case of a neglected compartment syndrome, it is widely accepted that delayed fasciotomies (more than 24 hours since initial presentation), are no beneficial to the patient, and they actually carry a risk of serious complications, such as infection, septicemia and amputation. Fasciotomies are also associated with stiffness, pain, cosmetic problems, nerve injury and chronic venous insufficiency [15, 16]. If the hand compartment syndrome is not managed properly, permanent loss of function is inevitable. Muscle contractures are developed and the hand sits in intrinsic minus position, with the MCPJs in extension and the PIPJs in flexion. Intrinsic plus contraction though is possible, if lumbricals muscles are predominantly affected. The first web space is contracted as well [2, 20].
Hand ischaemic contractures includes three groups. Group 1: All interrosei and thenar muscles are involved (typical Volkmann contracture). Group 2: thenar or interossei muscles are involved. Deformity concerns the thumb or the fingers. Group 3: one or more fingers are affected. Established intrinsic muscles contractures are treated with appropriate operative releases. The first web space is released and the tendons of the interossei muscles are released at the level of the metacarpal necks. Fibrotic tissue is removed. Detailed description of these operations are beyond the scope of this chapter [20, 21].
Hand compartment syndrome is an urgent condition which demands early recognition and treatment, otherwise it results to a permanent loss of function. Several controversies regarding diagnosis and management still exist in the contemporary literature. Future research should target on how a more accurate and early diagnosis can be achieved and the time frame beyond which fasciotomy is not beneficial to the patient. Fasciotomies of the hand are the cornerstone of treatment, and if they are performed early, they guarantee a good functional outcome. The surgeon should demonstrate a low threshold towards surgical release if compartment syndrome is suspected. Knowledge of the special anatomical features of the hand is necessary, in order for the physician to offer to the patient a sufficient treatment.
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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It often results in high productivity and requires large capital investments, low operating costs, and good safety conditions. The main topics that will be discussed in this chapter will include an introduction into the general features of open pit mining, ore body characteristics and configurations, stripping ratios and stripping overburden methods, mine elements and parameters, open pit operation cycle, pit slope angle, stability of mine slopes, types of highwall failures, mine closure and reclamation, and different variants of surface mining methods including opencast mining, mountainous mining, and artisan mining.",book:{id:"8620",slug:"mining-techniques-past-present-and-future",title:"Mining Techniques",fullTitle:"Mining Techniques - Past, Present and Future"},signatures:"Awwad H. Altiti, Rami O. Alrawashdeh and Hani M. 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The first stage contains the area recognition, its limitation to the target, and elimination of external factors until defining a geothermal zone with characteristics to be commercially exploited. The main studies and analysis that can be applied during the exploration stage are listed, and the major indicator to continue with the project or suspend is the prefeasibility report. The major risks in the exploration stage are due to studies that are carried out on the surface; at this stage, the costs can be considered low. The main results of the exploration are the selection of sites to drill three or four initial wells. Each well provides a direct overview of the reservoir: depth, production thicknesses, thermodynamic parameters, and production characteristics. The drilling of three to four exploratory wells is recommended, as far as there is certainty of the feasibility of the project, and the development of the field begins with drilling of sufficient wells to feed the plant. In this stage, the cost increases, but the risks decrease.",book:{id:"7504",slug:"renewable-geothermal-energy-explorations",title:"Renewable Geothermal Energy Explorations",fullTitle:"Renewable Geothermal Energy Explorations"},signatures:"Alfonso Aragón-Aguilar, Georgina Izquierdo-Montalvo,\nDaniel Octavio Aragón-Gaspar and Denise N. Barreto-Rivera",authors:[{id:"258358",title:"Dr.",name:"Alfonso",middleName:null,surname:"Aragón-Aguilar",slug:"alfonso-aragon-aguilar",fullName:"Alfonso Aragón-Aguilar"}]},{id:"65070",title:"Biochar: A Sustainable Approach for Improving Plant Growth and Soil Properties",slug:"biochar-a-sustainable-approach-for-improving-plant-growth-and-soil-properties",totalDownloads:6893,totalCrossrefCites:55,totalDimensionsCites:92,abstract:"Soil is the most important source and an abode for many nutrients and microflora. Due to rapid depletion of agricultural areas and soil quality by means of ever-increasing population and an excessive addition of chemical fertilizers, a rehabilitated attention is a need of the hour to maintain sustainable approaches in agricultural crop production. Biochar is the solid, carbon-rich material obtained by pyrolysis using different biomasses. It has been widely documented in previous studies that, the crop growth and yield can be increased by using biochar. This chapter exclusively summarizes the properties of biochar, its interaction with soil microflora, and its role in plant growth promotion when added to the soil.",book:{id:"7305",slug:"biochar-an-imperative-amendment-for-soil-and-the-environment",title:"Biochar",fullTitle:"Biochar - An Imperative Amendment for Soil and the Environment"},signatures:"Jyoti Rawat, Jyoti Saxena and Pankaj Sanwal",authors:null},{id:"39170",title:"Study of Impacts of Global Warming on Climate Change: Rise in Sea Level and Disaster Frequency",slug:"study-of-impacts-of-global-warming-on-climate-change-rise-in-sea-level-and-disaster-frequency",totalDownloads:6659,totalCrossrefCites:14,totalDimensionsCites:32,abstract:null,book:{id:"2206",slug:"global-warming-impacts-and-future-perspective",title:"Global Warming",fullTitle:"Global Warming - Impacts and Future Perspective"},signatures:"Bharat Raj Singh and Onkar Singh",authors:[{id:"26093",title:"Dr.",name:"Bharat Raj",middleName:null,surname:"Singh",slug:"bharat-raj-singh",fullName:"Bharat Raj Singh"},{id:"118426",title:"Prof.",name:"Onkar",middleName:null,surname:"Singh",slug:"onkar-singh",fullName:"Onkar Singh"}]}],onlineFirstChaptersFilter:{topicId:"10",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82332",title:"Introductory Chapter: Access to Space, Access to the Moon: Two Sides of the Same Coin?",slug:"introductory-chapter-access-to-space-access-to-the-moon-two-sides-of-the-same-coin",totalDownloads:8,totalDimensionsCites:0,doi:"10.5772/intechopen.105175",abstract:null,book:{id:"10955",title:"Lunar Science - Habitat and Humans",coverURL:"https://cdn.intechopen.com/books/images_new/10955.jpg"},signatures:"Yann-Henri Chemin"},{id:"82329",title:"Bifacial Photovoltaic Technology: Recent Advancements, Simulation and Performance Measurement",slug:"bifacial-photovoltaic-technology-recent-advancements-simulation-and-performance-measurement",totalDownloads:9,totalDimensionsCites:0,doi:"10.5772/intechopen.105152",abstract:"In this chapter, we introduce the physic principle and applications of bifacial PV technology. We present different bifacial PV cell and module technologies as well as investigate the advantages of using bifacial PV technology in the field. We describe the measurement and modeling of Albedo, which is one of the important factors for the energy yield of bifacial PV technology. For an accurate assessment of the performance ratio of bifacial PV strings, it is necessary to measure the albedo irradiance using an albedometer or the front- and rear-side plane of array (POA) irradiance. We also discuss the advanced techniques for the characterization of bifacial PV modules. By means of simulation, we give insight into what boundary conditions result in new bifacial technology gains and the influence of the mounting position of irradiance sensors. We executed several simulations by varying the sensor positions on the rear side of the PV modules, different places, different albedo numbers, mounting heights, different geographical locations with various tilts, seasons, and weather types. To validate the simulation results, we performed various experiments in the field under different conditions. The results prove that the bifacial gain is highly dependent on the mounting heights of PV modules, tilt angles, weather conditions, latitude, and location.",book:{id:"9862",title:"Solar Radiation - Measurements, Modeling and Forecasting for Photovoltaic Solar Energy Applications",coverURL:"https://cdn.intechopen.com/books/images_new/9862.jpg"},signatures:"Mohammadreza Aghaei, Marc Korevaar, Pavel Babal and Hesan Ziar"},{id:"79973",title:"Impacts of Drought on Homestead Plant Diversity in Barind Tract of Bangladesh",slug:"impacts-of-drought-on-homestead-plant-diversity-in-barind-tract-of-bangladesh",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.101885",abstract:"Homestead is a great place for household food access, diet, and nutrition. Drought affects homestead plant diversity and reduces production, availability, and diversity that lead toward less supply and consumption. Drought detains moisture and degrades the soil that supports plant growth. Homestead provides regular bread and income in the rural areas with an effective means for both economic and environmental well-being. People are getting a good amount of subsidiary income without any extra care and effort. In managing homestead land and drought, the household needs necessary technical and managerial training. In reducing drought effects to the homestead, action research needs to be carried out on available knowledge, effective practices, water management, and the adoption of local varieties and knowledge to develop effective homestead integration. Government initiatives, community engagement and not harming the environment, and efficient uses of water could be great solutions for the adverse effects of drought on the homestead plant diversity.",book:{id:"11131",title:"Drought - Impacts and Management",coverURL:"https://cdn.intechopen.com/books/images_new/11131.jpg"},signatures:"Md. Shafiqul Islam"},{id:"81757",title:"Petroleum Geochemistry",slug:"petroleum-geochemistry",totalDownloads:17,totalDimensionsCites:0,doi:"10.5772/intechopen.104709",abstract:"Petroleum geochemistry has entered its second period of growth. The first period, largely associated with conventional oil and gas, occurred in the 70s and 80s when the classic works on source rock characterization, biomarkers, depositional systems, and petroleum generation, including kinetics and basin modeling were the focus. The second period began slightly after the turn of the century as a consequence of the “unconventional resource” revolution and the interest in distressed resources developed, the focus turned to non-hydrocarbon contaminants, new interest in hydrocarbon expulsion and retention, identification of tight rock pay zones, and the development of organic porosity. This chapter will discuss source rock characterization and formation, petroleum generation, expulsion, and retention, correlation among hydrocarbon accumulations and to their source rock(s), and organic porosity.",book:{id:"11139",title:"Geochemistry and Mineral Resources",coverURL:"https://cdn.intechopen.com/books/images_new/11139.jpg"},signatures:"Mei Mei and Barry Katz"},{id:"82130",title:"Dynamics, Anomalies and Boundaries of the Forest-Savanna Transition: A Novel Remote Sensing-Based Multi-Angles Methodology Using Google Earth Engine",slug:"dynamics-anomalies-and-boundaries-of-the-forest-savanna-transition-a-novel-remote-sensing-based-mult",totalDownloads:8,totalDimensionsCites:0,doi:"10.5772/intechopen.105074",abstract:"This chapter proposes a remote sensing multi-angles methodology to assess the transition at the interface of the forest-savanna land cover. On Sentinel2-A median images of successive dry seasons, three referential and nine analytical spectral indices were computed. The change vector analysis (CVA) was performed, selecting further one magnitude per index. The averaged moving standard deviation index (aMSDI) was proposed to compare spatial intensity of anomalies among selected CVA, and then statistically assessed through spatial and no-spatial autoregression tests. The cross-correlation and simple linear combination (SCL) computations spotted the overall anomaly extent. Three machine learning algorithms, i.e., classification and regression trees (CART), random forest (RF), and support vector machine (SVM), helped mapping the distribution of each specie. As result, the CVA confirmed each index ability to add new information. The aMSDI gave the harmonized interval [0–0.083] among CVA, confirmed with all p−values=0, z−scores>2.5, clustering of anomaly pixel,and adjusted R2≤0.19. Three trends of vegetation distribution were distinguished with 88.7% overall accuracy and 0.86 kappa coefficient. Finally, extremely affected areas were spotted in upper latitudes towards Sahel and desert.",book:{id:"11488",title:"GIS and Spatial Analysis",coverURL:"https://cdn.intechopen.com/books/images_new/11488.jpg"},signatures:"Alfred Homère Ngandam Mfondoum, Igor Casimir Njombissie Petcheu, Frederic Chamberlain Lounang Tchatchouang, Luc Moutila Beni, Mesmin Tchindjang and Jean Valery Mefire Mfondoum"},{id:"81911",title:"Cryovolcanism in the Solar System and Beyond: Considerations on Energy Sources, Geological Aspects, and Astrobiological Perspectives",slug:"cryovolcanism-in-the-solar-system-and-beyond-considerations-on-energy-sources-geological-aspects-and",totalDownloads:12,totalDimensionsCites:0,doi:"10.5772/intechopen.105067",abstract:"Volcanism based on melting rocks (silicate volcanism) is long known on Earth and has also been found on Jupiter’s moon Io. Remnants of this type of volcanism have been identified also on other bodies in the solar system. Energy sources powered by accretion and the decay of radioactive isotopes seem to be dominant mainly inside larger bodies, which have enough volume to accumulate and retain this energy in significant amounts. On the other hand, the impact of tidal forces allows even tiny bodies to melt up and pass into the stage of cryovolcanism. The dependence of tidal heating on the size of the object is minor, but the masses of and the distances to accompanying bodies as well as the inner compositions of the heated body are central factors. Even though Io as an example of a body supporting silicate volcanism is striking, the physics of tidal forces might suggest a relatively high probability for cryovolcanism. This chapter aims at considering the parameters known and objects found so far in our solar system to give insights into where in our system and other planetary systems cryovolcanism might be expected.",book:{id:"11737",title:"Astronomy",coverURL:"https://cdn.intechopen.com/books/images_new/11737.jpg"},signatures:"Georg Hildenbrand, Klaus Paschek, Myriam Schäfer and Michael Hausmann"}],onlineFirstChaptersTotal:148},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:31,numberOfPublishedChapters:315,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:14,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"7",title:"Bioinformatics and Medical Informatics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",isOpenForSubmission:!0,editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",slug:"slawomir-wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",biography:"Professor Sławomir Wilczyński, Head of the Chair of Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, Poland. His research interests are focused on modern imaging methods used in medicine and pharmacy, including in particular hyperspectral imaging, dynamic thermovision analysis, high-resolution ultrasound, as well as other techniques such as EPR, NMR and hemispheric directional reflectance. Author of over 100 scientific works, patents and industrial designs. Expert of the Polish National Center for Research and Development, Member of the Investment Committee in the Bridge Alfa NCBiR program, expert of the Polish Ministry of Funds and Regional Policy, Polish Medical Research Agency. Editor-in-chief of the journal in the field of aesthetic medicine and dermatology - Aesthetica.",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},{id:"8",title:"Bioinspired Technology and Biomechanics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",isOpenForSubmission:!0,editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",slug:"adriano-andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",biography:"Dr. Adriano de Oliveira Andrade graduated in Electrical Engineering at the Federal University of Goiás (Brazil) in 1997. He received his MSc and PhD in Biomedical Engineering respectively from the Federal University of Uberlândia (UFU, Brazil) in 2000 and from the University of Reading (UK) in 2005. He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). He was the head of the undergraduate program in Biomedical Engineering of the Federal University of Uberlândia (2015 - June/2019) and the head of the Centre for Innovation and Technology Assessment in Health (NIATS/UFU) since 2010. He is the head of the Postgraduate Program in Biomedical Engineering (UFU, July/2019 - to date). He was the secretary of the Parkinson's Disease Association of Uberlândia (2018-2019). Dr. Andrade's primary area of research is focused towards getting information from the neuromuscular system to understand its strategies of organization, adaptation and controlling in the context of motor neuron diseases. His research interests include Biomedical Signal Processing and Modelling, Assistive Technology, Rehabilitation Engineering, Neuroengineering and Parkinson's Disease.",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",isOpenForSubmission:!0,editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",biography:"Dr. Luis Villarreal is a research professor from the Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Tijuana, Baja California, México. Dr. Villarreal is the editor in chief and founder of the Revista de Ciencias Tecnológicas (RECIT) (https://recit.uabc.mx/) and is a member of several editorial and reviewer boards for numerous international journals. He has published more than thirty international papers and reviewed more than ninety-two manuscripts. 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Banigo, Chigozie A. Nnadiekwe and Emmanuel M. 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His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Associate Prof.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"333824",title:"Dr.",name:"Ahmad Farouk",middleName:null,surname:"Musa",slug:"ahmad-farouk-musa",fullName:"Ahmad Farouk Musa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333824/images/22684_n.jpg",biography:"Dato’ Dr Ahmad Farouk Musa\nMD, MMED (Surgery) (Mal), Fellowship in Cardiothoracic Surgery (Monash Health, Aust), Graduate Certificate in Higher Education (Aust), Academy of Medicine (Mal)\n\n\n\nDato’ Dr Ahmad Farouk Musa obtained his Doctor of Medicine from USM in 1992. He then obtained his Master of Medicine in Surgery from the same university in the year 2000 before subspecialising in Cardiothoracic Surgery at Institut Jantung Negara (IJN), Kuala Lumpur from 2002 until 2005. He then completed his Fellowship in Cardiothoracic Surgery at Monash Health, Melbourne, Australia in 2008. He has served in the Malaysian army as a Medical Officer with the rank of Captain upon completing his Internship before joining USM as a trainee lecturer. He is now serving as an academic and researcher at Monash University Malaysia. He is a life-member of the Malaysian Association of Thoracic & Cardiovascular Surgery (MATCVS) and a committee member of the MATCVS Database. He is also a life-member of the College of Surgeons, Academy of Medicine of Malaysia; a life-member of Malaysian Medical Association (MMA), and a life-member of Islamic Medical Association of Malaysia (IMAM). Recently he was appointed as an Interim Chairperson of Examination & Assessment Subcommittee of the UiTM-IJN Cardiothoracic Surgery Postgraduate Program. As an academic, he has published numerous research papers and book chapters. He has also been appointed to review many scientific manuscripts by established journals such as the British Medical Journal (BMJ). He has presented his research works at numerous local and international conferences such as the European Association for Cardiothoracic Surgery (EACTS) and the European Society of Cardiovascular Surgery (ESCVS), to name a few. He has also won many awards for his research presentations at meetings and conferences like the prestigious International Invention, Innovation & Technology Exhibition (ITEX); Design, Research and Innovation Exhibition, the National Conference on Medical Sciences and the Annual Scientific Meetings of the Malaysian Association for Thoracic and Cardiovascular Surgery. He was awarded the Darjah Setia Pangkuan Negeri (DSPN) by the Governor of Penang in July, 2015.",institutionString:null,institution:{name:"Monash University Malaysia",country:{name:"Malaysia"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. 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