Constant values respect the rim angle.
\\n\\n
Dr. Pletser’s experience includes 30 years of working with the European Space Agency as a Senior Physicist/Engineer and coordinating their parabolic flight campaigns, and he is the Guinness World Record holder for the most number of aircraft flown (12) in parabolas, personally logging more than 7,300 parabolas.
\\n\\nSeeing the 5,000th book published makes us at the same time proud, happy, humble, and grateful. This is a great opportunity to stop and celebrate what we have done so far, but is also an opportunity to engage even more, grow, and succeed. It wouldn't be possible to get here without the synergy of team members’ hard work and authors and editors who devote time and their expertise into Open Access book publishing with us.
\\n\\nOver these years, we have gone from pioneering the scientific Open Access book publishing field to being the world’s largest Open Access book publisher. Nonetheless, our vision has remained the same: to meet the challenges of making relevant knowledge available to the worldwide community under the Open Access model.
\\n\\nWe are excited about the present, and we look forward to sharing many more successes in the future.
\\n\\nThank you all for being part of the journey. 5,000 times thank you!
\\n\\nNow with 5,000 titles available Open Access, which one will you read next?
\\n\\nRead, share and download for free: https://www.intechopen.com/books
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'
Preparation of Space Experiments edited by international leading expert Dr. Vladimir Pletser, Director of Space Training Operations at Blue Abyss is the 5,000th Open Access book published by IntechOpen and our milestone publication!
\n\n"This book presents some of the current trends in space microgravity research. The eleven chapters introduce various facets of space research in physical sciences, human physiology and technology developed using the microgravity environment not only to improve our fundamental understanding in these domains but also to adapt this new knowledge for application on earth." says the editor. Listen what else Dr. Pletser has to say...
\n\n\n\nDr. Pletser’s experience includes 30 years of working with the European Space Agency as a Senior Physicist/Engineer and coordinating their parabolic flight campaigns, and he is the Guinness World Record holder for the most number of aircraft flown (12) in parabolas, personally logging more than 7,300 parabolas.
\n\nSeeing the 5,000th book published makes us at the same time proud, happy, humble, and grateful. This is a great opportunity to stop and celebrate what we have done so far, but is also an opportunity to engage even more, grow, and succeed. It wouldn't be possible to get here without the synergy of team members’ hard work and authors and editors who devote time and their expertise into Open Access book publishing with us.
\n\nOver these years, we have gone from pioneering the scientific Open Access book publishing field to being the world’s largest Open Access book publisher. Nonetheless, our vision has remained the same: to meet the challenges of making relevant knowledge available to the worldwide community under the Open Access model.
\n\nWe are excited about the present, and we look forward to sharing many more successes in the future.
\n\nThank you all for being part of the journey. 5,000 times thank you!
\n\nNow with 5,000 titles available Open Access, which one will you read next?
\n\nRead, share and download for free: https://www.intechopen.com/books
\n\n\n\n
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"10875",leadTitle:null,fullTitle:"Infertility and Assisted Reproduction",title:"Infertility and Assisted Reproduction",subtitle:null,reviewType:"peer-reviewed",abstract:"Infertility affects approximately 15% of couples of reproductive age. High live birth rates rely on many advanced technologies in infertility treatment, including more accurate clinical diagnosis and patient management as well as state-of-the-art in vitro fertilization (IVF) technologies. This book discusses infertility and infertility treatments such as embryo implantation, non-invasive preimplantation genetic diagnosis (PGT), oocyte cryopreservation, cryopreservation of small numbers of sperm, and embryo culture technologies. It delivers new information and data valuable to clinicians, embryologists, and others in infertility treatment.",isbn:"978-1-83962-825-2",printIsbn:"978-1-83962-824-5",pdfIsbn:"978-1-83962-829-0",doi:"10.5772/intechopen.95184",price:119,priceEur:129,priceUsd:155,slug:"infertility-and-assisted-reproduction",numberOfPages:244,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"0e5dec5733cec3edc1891afcc7436eed",bookSignature:"Wei-Hua Wang",publishedDate:"November 17th 2021",coverURL:"https://cdn.intechopen.com/books/images_new/10875.jpg",numberOfDownloads:2398,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:1,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:1,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 12th 2021",dateEndSecondStepPublish:"March 12th 2021",dateEndThirdStepPublish:"May 11th 2021",dateEndFourthStepPublish:"July 30th 2021",dateEndFifthStepPublish:"September 28th 2021",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"336024",title:"Dr.",name:"Wei-Hua",middleName:null,surname:"Wang",slug:"wei-hua-wang",fullName:"Wei-Hua Wang",profilePictureURL:"https://mts.intechopen.com/storage/users/336024/images/system/336024.jpg",biography:"Wei-Hua Wang is laboratory director at Aspire-Houston Fertility Institute, Prelude Fertility/Inception, Texas. He has twenty-five years of experience in in vitro fertilization (IVF) services. He has established one of the largest frozen donor egg banks in the United States. He was also an adjunct professor at the Chinese Academy of Sciences, Lanzhou University, and Guangzhou Medical University. His research has been recognized internationally and has received numerous awards including a General Program Prize (meiotic spindle imaging in living human oocytes) from the American Society for Reproductive Medicine in 1999. He has published more than 100 research papers in peer-reviewed journals and books, and these papers have been cited more than 7000 times. Dr. Wang also serves as an active reviewer for about twenty international journals.",institutionString:"Prelude Fertility",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Houston Fertility Institute",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1069",title:"Reproductive Endocrinology and Infertility",slug:"obstetrics-and-gynecology-reproductive-endocrinology-and-infertility"}],chapters:[{id:"76970",title:"Reasons and Mechanisms of Recurrent Failed Implantation in IVF",doi:"10.5772/intechopen.98301",slug:"reasons-and-mechanisms-of-recurrent-failed-implantation-in-ivf",totalDownloads:208,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF) are serious problems in IVF and ICSI cycles. Different factors are showed to be responsible for these clinical challenges – such as paternal, maternal, embryonic, immunological, infectious, hormonal, and others. In this chapter we have tried to review the available data on reasons for the RIF, and systematize them into: 1) uterine factors; 2) embryo factors; 3) immunological factors; 4) other factors. Interplay between all these factors play a role in RIF, and further investigations are needed to elucidate their significance and interactions – in order to elaborate more definite suggestions or guidelines for the clinicians dealing with artificial reproductive techniques and facing RPL and RIF.",signatures:"Violeta Fodina, Alesja Dudorova and Juris Erenpreiss",downloadPdfUrl:"/chapter/pdf-download/76970",previewPdfUrl:"/chapter/pdf-preview/76970",authors:[{id:"350570",title:"Ph.D.",name:"Juris",surname:"Erenpreiss",slug:"juris-erenpreiss",fullName:"Juris Erenpreiss"},{id:"417438",title:"Dr.",name:"Violeta",surname:"Fodina",slug:"violeta-fodina",fullName:"Violeta Fodina"},{id:"417439",title:"Dr.",name:"Alesja",surname:"Dudorova",slug:"alesja-dudorova",fullName:"Alesja Dudorova"}],corrections:null},{id:"77153",title:"Recurrent Implantation Failure: The Role of Anatomical Causes",doi:"10.5772/intechopen.98505",slug:"recurrent-implantation-failure-the-role-of-anatomical-causes",totalDownloads:260,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Recurrent implantation failure (RIF) is one of the great challenges of current reproductive medicine. The term refers to the failure of repeated transfers of embryos of good morphological quality. Embryo implantation is a crucial moment in in vitro fertilization (IVF) treatments. A successful pregnancy depends on a synchronized interaction between a good quality embryo and a receptive endometrium. Its failure may be a consequence of embryo quality, anatomical or immunological factors. The anatomic causes constitute an important factor for RIF, although they are usually manageable. Fibroids, polyps and adhesions that develop after a surgical procedure or infection can hamper the embryo - endometrium attachment process. In addition, Mullerian abnormalities and hydrosalpinx can cause a negative impact on implantation rates and should also be taken into account in patients with RIF. In this chapter, we will address the main anatomical causes that may impact the implantation rates of patients undergoing IVF, as well as recommendations on management and its treatment.",signatures:"Mariana Fonseca Roller Barcelos, Aluisio M. da Rocha Filho, Amanda Evelyn C. Goulart, Anna Luiza M. Souza, Daniely T. Costa, Gabriela Galdino de F. Barros, Isadora Manzi N. Theodoro, Jean Pierre B. Brasileiro, Murilo Cezar S. Oliveira, Natalia I. Zavattiero Tierno, Tatianna Quintas F. Ribeiro, Valeria L. Mathias Castro and Vinicius M. Lopes",downloadPdfUrl:"/chapter/pdf-download/77153",previewPdfUrl:"/chapter/pdf-preview/77153",authors:[{id:"310745",title:"Mr.",name:"Murilo C.",surname:"Souza-Oliveira",slug:"murilo-c.-souza-oliveira",fullName:"Murilo C. Souza-Oliveira"},{id:"310747",title:"Ms.",name:"Amanda Evelyn C.",surname:"Goulart",slug:"amanda-evelyn-c.-goulart",fullName:"Amanda Evelyn C. Goulart"},{id:"310748",title:"Ms.",name:"Natalia I. Zavattiero",surname:"Tierno",slug:"natalia-i.-zavattiero-tierno",fullName:"Natalia I. Zavattiero Tierno"},{id:"310749",title:"MSc.",name:"Anna Luiza Moraes",surname:"Souza",slug:"anna-luiza-moraes-souza",fullName:"Anna Luiza Moraes Souza"},{id:"310750",title:"Mr.",name:"Jean Pierre B.",surname:"Brasileiro",slug:"jean-pierre-b.-brasileiro",fullName:"Jean Pierre B. Brasileiro"},{id:"310760",title:"Ms.",name:"Tatianna Q. F.",surname:"Ribeiro",slug:"tatianna-q.-f.-ribeiro",fullName:"Tatianna Q. F. Ribeiro"},{id:"350714",title:"M.D.",name:"Mariana",surname:"Barcelos",slug:"mariana-barcelos",fullName:"Mariana Barcelos"},{id:"353175",title:"Dr.",name:"Vinicius M.",surname:"Lopes",slug:"vinicius-m.-lopes",fullName:"Vinicius M. Lopes"},{id:"353179",title:"Mr.",name:"Aluisio Mendes R.",surname:"Filho",slug:"aluisio-mendes-r.-filho",fullName:"Aluisio Mendes R. Filho"},{id:"353181",title:"Ms.",name:"Isadora Manzi Novais",surname:"Theodoro",slug:"isadora-manzi-novais-theodoro",fullName:"Isadora Manzi Novais Theodoro"},{id:"353237",title:"Ms.",name:"Gabriela Galdino De F.",surname:"Barros",slug:"gabriela-galdino-de-f.-barros",fullName:"Gabriela Galdino De F. Barros"},{id:"353447",title:"Ms.",name:"Daniely Toledo",surname:"Costa",slug:"daniely-toledo-costa",fullName:"Daniely Toledo Costa"},{id:"353458",title:"Ms.",name:"Valeria Leal",surname:"Mathias",slug:"valeria-leal-mathias",fullName:"Valeria Leal Mathias"}],corrections:null},{id:"77438",title:"Fibroids and Infertility",doi:"10.5772/intechopen.98402",slug:"fibroids-and-infertility",totalDownloads:180,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Uterine fibroids (also known as leiomyomas or myomas) are the most common pelvic tumors, affecting more than 70% of women over 70 years of age and although most are asymptomatic, some women may experience symptoms, depending on their location and size, which can alter your quality of life, such as abnormal uterine bleeding, anemia, pelvic pain and pressure, dyspareunia, increased urinary frequency and constipation. Its relationship with infertility has been controversial and, although insignificant for subserous fibroids, it appears that submucosal and intramural fibroids that distort the endometrial cavity can affect embryo implantation and are associated with an increased risk of early pregnancy loss. Its treatment will depend on the patient’s symptoms, size, location, whether it is one or multiple, and whether or not she suffers from infertility. It is clear that submucosal fibroids have a negative impact on fertility and with respect to intramural fibroids it is known that fibroids larger than 4 cm alter the probability of pregnancy, however there are studies that show that even smaller or multiple fibroids could affect pregnancy rates. There are multiple options for the treatment of fibroids; however, patients who are candidates for expectant, medical or surgical management should be individualized, and especially if they are going to be taken to surgery, an excellent mapping of fibroids prior to surgical intervention is recommended. Minimally invasive surgery continues to be the approach of choice, it should be left for the open approach in cases in which Laparoscopy is contraindicated or the patient with multiple myomatosis.",signatures:"Juan Luis Giraldo Moreno and Susana Salazar López",downloadPdfUrl:"/chapter/pdf-download/77438",previewPdfUrl:"/chapter/pdf-preview/77438",authors:[{id:"414557",title:"Dr.",name:"Susana",surname:"Salazar López",slug:"susana-salazar-lopez",fullName:"Susana Salazar López"},{id:"414562",title:"Dr.",name:"Juan Luis",surname:"Giraldo",slug:"juan-luis-giraldo",fullName:"Juan Luis Giraldo"}],corrections:null},{id:"77309",title:"Endometrial Receptivity in Patients with Polycystic Ovary Syndrome",doi:"10.5772/intechopen.98624",slug:"endometrial-receptivity-in-patients-with-polycystic-ovary-syndrome",totalDownloads:223,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Polycystic ovary syndrome (PCOS) is a frequent disorder affecting women of reproductive age characterized by infertility. Affected endometrial receptivity seems to contribute to decreased fertility of these patients as suggested by several studies. Understanding the mechanism behind this reduced endometrial receptivity could contribute to discovery of new therapeutic targets for infertility of PCOS. The aim of the paper is to review the current data regarding endometrial receptivity in PCOS patients, the potential mechanisms involved with particular focus on recent findings as the impact of gut microbiota on endometrium, the relationship between vitamin D and endometrial receptivity and the different impact of letrozole and clomiphene citrate on endometrial receptivity in infertile PCOS women.",signatures:"Alice Albu and Dragoș Albu",downloadPdfUrl:"/chapter/pdf-download/77309",previewPdfUrl:"/chapter/pdf-preview/77309",authors:[{id:"200829",title:"Dr.",name:"Alice",surname:"Albu",slug:"alice-albu",fullName:"Alice Albu"},{id:"207984",title:"Dr.",name:"Dragoș",surname:"Albu",slug:"dragos-albu",fullName:"Dragoș Albu"}],corrections:null},{id:"78541",title:"Non-Invasive Chromosome Screening for Embryo Preimplantation Using Cell-Free DNA",doi:"10.5772/intechopen.98416",slug:"non-invasive-chromosome-screening-for-embryo-preimplantation-using-cell-free-dna",totalDownloads:118,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Preimplantation genetic testing (PGT) is widely adopted to select embryos with normal ploidy but requires invasive embryo biopsy procedures. Therefore, non-invasive PGT (niPGT) detection of cell-free DNA (cfDNA) in blastocyst culture medium has gradually become a hot area in the field of assisted reproduction. This chapter will systematically summarize how researchers use embryonic cfDNA to conduct niPGT detection worldwide. It will also thoroughly review the factors that affect the accuracy of the test and its underlying issues, as well as prospective applications. We hope to provide a useful reference for the standardized operation of non-invasive PGT that can be widely applied in clinical practice.",signatures:"Jin Huang, Yaxin Yao, Yan Zhou, Jialin Jia, Jing Wang, Jun Ren, Ping Liu and Sijia Lu",downloadPdfUrl:"/chapter/pdf-download/78541",previewPdfUrl:"/chapter/pdf-preview/78541",authors:[{id:"352804",title:"Ph.D.",name:"yaxin",surname:"Yao",slug:"yaxin-yao",fullName:"yaxin Yao"},{id:"418238",title:"Dr.",name:"Yan",surname:"Zhou",slug:"yan-zhou",fullName:"Yan Zhou"},{id:"418242",title:"Dr.",name:"Jun",surname:"Ren",slug:"jun-ren",fullName:"Jun Ren"},{id:"418382",title:"Dr.",name:"Sijia",surname:"Lu",slug:"sijia-lu",fullName:"Sijia Lu"},{id:"418383",title:"Ms.",name:"Jing",surname:"Wang",slug:"jing-wang",fullName:"Jing Wang"},{id:"418388",title:"Dr.",name:"Jin",surname:"Huang",slug:"jin-huang",fullName:"Jin Huang"},{id:"418391",title:"Prof.",name:"Ping",surname:"Liu",slug:"ping-liu",fullName:"Ping Liu"}],corrections:null},{id:"77127",title:"You Have a New Super Power: Ethics of Oocyte Cryopreservation",doi:"10.5772/intechopen.98392",slug:"you-have-a-new-super-power-ethics-of-oocyte-cryopreservation",totalDownloads:132,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter will be an ethical analysis on challenging situations surrounding oocyte cryopreservation treatment in young healthy women. There has been always a complicated interaction between technology and changing societal values. This ethical discussion is not on whether or not oocyte cryopreservation in itself is ethically justifiable. Through a comprehensive literature review, this chapter discusses some ethical aspects that have emerged since oocyte cryopreservation was applied for the first time. Through a practical approach, this chapter address ethical uncertainties presenting case studies, ethical questions and terms, existing arguments in favor and against oocyte cryopreservation; and examine the individual patient’s beliefs, perception and opinions.",signatures:"Leila Mohammadi, Silvia Martinez and Daniel Aranda",downloadPdfUrl:"/chapter/pdf-download/77127",previewPdfUrl:"/chapter/pdf-preview/77127",authors:[{id:"350094",title:"Ph.D.",name:"Leila",surname:"Mohammadi",slug:"leila-mohammadi",fullName:"Leila Mohammadi"},{id:"419999",title:"Dr.",name:"Silvia",surname:"Martinez",slug:"silvia-martinez",fullName:"Silvia Martinez"}],corrections:null},{id:"77336",title:"Efficiency of Autologous Egg Cryopreservation: Eight Years’ Experiences and Clinical Outcomes",doi:"10.5772/intechopen.98675",slug:"efficiency-of-autologous-egg-cryopreservation-eight-years-experiences-and-clinical-outcomes",totalDownloads:136,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Oocyte cryopreservation is one of the state-of-art technologies in human reproductive medicine, which brings opportunities for women to preserve their fertility. In the present study, we analyzed the efficiency and outcomes of 8 years’ autologous egg cryopreservation: Frozen oocytes were warmed from 120 cycles and oocyte survival, fertilization, blastocyst development, clinical pregnancy, embryo implantation, live birth rates and birth weights were collected based on the patients’ ages of <35, 35–37 and > 37 years old. The details of oocyte cryopreservation and the efficiency were further analyzed based on different patient categories. During the study period, 849 oocytes from 120 cycles were warmed. Oocyte survival, fertilization, and blastocyst development were not affected by women’s ages at the time of cryopreservation. However, number of patients without blastocyst formation was significantly (P < 0.05) higher in patients >37 years old (31.2%) than that in patients <35 years old (13.1%). Higher live birth rates were observed in patients <35 (51.1%) and 35–37 (46.7%) years old than in patients >37 years old (28.6%) after fresh embryo transfer. Some patients did not have blastocysts mainly due to low fertilization by poor sperm or small number of oocytes warmed. These results indicate that the efficiency of oocyte cryopreservation, evaluated by live birth and embryo implantation rates is affected by women’s age, number of oocytes warmed and sperm quality.",signatures:"Cassie T. Wang, Xiangli Niu, Qiuyan Ruan and Wei-Hua Wang",downloadPdfUrl:"/chapter/pdf-download/77336",previewPdfUrl:"/chapter/pdf-preview/77336",authors:[{id:"336024",title:"Dr.",name:"Wei-Hua",surname:"Wang",slug:"wei-hua-wang",fullName:"Wei-Hua Wang"},{id:"422270",title:"Dr.",name:"Cassie T.",surname:"Wang",slug:"cassie-t.-wang",fullName:"Cassie T. Wang"},{id:"422271",title:"Dr.",name:"Xiangli",surname:"Niu",slug:"xiangli-niu",fullName:"Xiangli Niu"},{id:"422272",title:"Dr.",name:"Qiuyan",surname:"Ruan",slug:"qiuyan-ruan",fullName:"Qiuyan Ruan"}],corrections:null},{id:"78354",title:"Understanding Male Infertility for Promising ART",doi:"10.5772/intechopen.98504",slug:"understanding-male-infertility-for-promising-art",totalDownloads:189,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Infertility is a serious problem of not being able to conceive despite regular intercourse for more than a year. Natural conception is seen to be achieved in 80%–85% of couples. About 15% of couples suffer infertility with male factor contributing to almost 50% of cases. Paradoxically, on traditional assessment, the underlying etiology of male contribution towards infertility remains unrecognized in 30% of the patients and thereby grouped as idiopathic. Diagnostics of male infertility cannot therefore be limited to usual semen analysis only. The spectrum of the recent research encourages the experts in the field to approach the Clinical, Molecular and cytogenetic shades associated with the problem besides secondary factors like life style and environment. Clinical assessment sums the medical history and physical examination of the affected individual. Molecular and cytogenetic analysis help gain new insights in understanding the problem and thereby an advantage for a successful assisted reproductive treatment (ART). Given the cost and burden ART puts in and prior to application of any invasive techniques, understanding precisely the etiology associated with male infertility is essential for the fertility specialist to circumvent inefficient or any unproductive steps in the fertilization process besides helping in counseling patients on their chance of success with the use of reproductive technology.",signatures:"Mahrukh Hameed Zargar, Faisel Ahmad, Mohammad Lateef and Tahir Mohiuddin Malla",downloadPdfUrl:"/chapter/pdf-download/78354",previewPdfUrl:"/chapter/pdf-preview/78354",authors:[{id:"353303",title:"Mr.",name:"Faisel",surname:"Ahmad",slug:"faisel-ahmad",fullName:"Faisel Ahmad"},{id:"354227",title:"Dr.",name:"Mahruk",surname:"Zargar",slug:"mahruk-zargar",fullName:"Mahruk Zargar"},{id:"354229",title:"Dr.",name:"Mohammad Lateef",surname:"Khaliq",slug:"mohammad-lateef-khaliq",fullName:"Mohammad Lateef Khaliq"},{id:"354230",title:"Dr.",name:"Tahir Mohuidin",surname:"Malla",slug:"tahir-mohuidin-malla",fullName:"Tahir Mohuidin Malla"}],corrections:null},{id:"78364",title:"Effect of Heavy Metals on Tyrosine Kinases Signaling during Sperm Capacitation",doi:"10.5772/intechopen.99261",slug:"effect-of-heavy-metals-on-tyrosine-kinases-signaling-during-sperm-capacitation",totalDownloads:146,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Sperm capacitation is the key event prior to fertilization. Success rate of currently used assisted reproductive technology like in-vitro fertilization is 50% dependent on sperm maturation or capacitation. In-vivo capacitation occur almost in female reproductive tract in response to various signaling or enzymatic molecules. Interestingly, both early and late events of capacitation are centrally regulated by protein kinase A (PKA). Influx of Ca2+ and HCO3-transmembrane drive leads to change in pH and intracellular cAMP which ultimately activate PKA regulated capacitation. PKA phosphorylates several target proteins that are presumed to initiate different signaling pathways. Some divalent heavy metals like lead, mercury, arsenic and cadmium mimic Ca++ entry and its functions and ultimately affect capacitation by inhibiting or inducing tyrosine phosphorylation. In this chapter we review the mechanism of heavy metals by which they affect the tyrosine phosphorylation during sperm capacitation.",signatures:"Bhawna Kushwaha, Rohit Beniwal, Aradhana Mohanty, Ajay Kumar Singh, Raj Kumar Yadav and Satish Kumar Garg",downloadPdfUrl:"/chapter/pdf-download/78364",previewPdfUrl:"/chapter/pdf-preview/78364",authors:[{id:"341307",title:"Dr.",name:"Bhawna",surname:"Kushawaha",slug:"bhawna-kushawaha",fullName:"Bhawna Kushawaha"},{id:"427602",title:"Dr.",name:"Rohit",surname:"Beniwal",slug:"rohit-beniwal",fullName:"Rohit Beniwal"},{id:"427603",title:"Dr.",name:"Lava Kumar",surname:"Surarapu",slug:"lava-kumar-surarapu",fullName:"Lava Kumar Surarapu"},{id:"427604",title:"Dr.",name:"Aradhana",surname:"Mohanty",slug:"aradhana-mohanty",fullName:"Aradhana Mohanty"},{id:"427605",title:"Dr.",name:"Ajay Kumar",surname:"Singh",slug:"ajay-kumar-singh",fullName:"Ajay Kumar Singh"},{id:"427606",title:"Dr.",name:"Satish Kumar",surname:"Garg",slug:"satish-kumar-garg",fullName:"Satish Kumar Garg"}],corrections:null},{id:"77009",title:"Rare Sperm Freezing",doi:"10.5772/intechopen.98388",slug:"rare-sperm-freezing",totalDownloads:188,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Gamete cryobanking has been widely incorporated in present assisted reproductive technology (ART). Preserving male gametes for future fertility is considered to be an easy and accessible way to insure one’s reproduction. Despite the fact that the method could not secure success, sperm freezing could be the only chance to father biological offspring. In cases when severe male factor (SMF) infertility is diagnosed (retrograde ejaculation, virtual azoospermia, obstructive azoospermia, cryptozoospermia) and providing fresh semen samples for assisted reproduction may alter chances to achieve pregnancy, rare sperm cryopreservation could contribute for conceiving. Isolation, selection and cryopreservation of single sperm cells from semen samples is a challenging procedure. Different approaches and devices could be used in order to extract utmost spermatozoa. Aiming to highest cryosurvival rates sperm freezing protocols should be carefully considered. For some men, rare sperm cryopreservation might be the only alternative for parenting biological offspring. Thus, the latter technique should be widely discussed, developed and practiced in assisted reproduction.",signatures:"Desislava Dyulgerova-Nikolova and Tanya Milachich",downloadPdfUrl:"/chapter/pdf-download/77009",previewPdfUrl:"/chapter/pdf-preview/77009",authors:[{id:"286468",title:"Ph.D.",name:"Tanya",surname:"Milachich",slug:"tanya-milachich",fullName:"Tanya Milachich"},{id:"286483",title:"Mrs.",name:"Desislava",surname:"Dyulgerova-Nikolova",slug:"desislava-dyulgerova-nikolova",fullName:"Desislava Dyulgerova-Nikolova"}],corrections:null},{id:"77268",title:"A Method for Small Number of Human Sperm Cryopreservation",doi:"10.5772/intechopen.98674",slug:"a-method-for-small-number-of-human-sperm-cryopreservation",totalDownloads:170,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Recently, some sperm vitrification devices were developed to simplify the procedures to freeze small number of human sperm. In the present study, we used these devices to further examine some factors that affect sperm motility after fast freezing. Experiments were designed to examine the effects of 1) direct immersion of the devices to liquid nitrogen and indirect immersion of the devices to liquid nitrogen in which the devices were sealed in cryogenic storage vials; 2) different freezing volumes (1–5 μl); 3) different equilibration times (1–5 min); and 4) different ratio of freezing solution (0,1-5,1) on post thawing sperm motility. It was found that fast sperm freezing in the sealed vials had high post thawing sperm motility (91.3–93.7% of recovered sperm motility rates) while direct immersion of the devices to liquid nitrogen had 0% post thawing sperm motility. No differences in the recovered sperm motility rates were observed between different freezing solution volumes (87.4–90.5%), different equilibration times (89.5–94.0%), and different freezing solution ratios (90.8–94.6%). However, only 6.8% of recovered sperm motility rate was obtained if sperm were frozen in the medium without sperm freezing solution. These results indicate that human sperm can be rapidly frozen after the devices are sealed in the vials with different equilibration time in the medium containing sperm freezing solution. High post thawing sperm motility can be recovered with this method so that ~90% of sperm are usable after freezing.",signatures:"Xiangli Niu, Hua Huang, Yi Mo, Yan Sun and Wei-Hua Wang",downloadPdfUrl:"/chapter/pdf-download/77268",previewPdfUrl:"/chapter/pdf-preview/77268",authors:[{id:"336024",title:"Dr.",name:"Wei-Hua",surname:"Wang",slug:"wei-hua-wang",fullName:"Wei-Hua Wang"},{id:"343676",title:"Dr.",name:"Xiangli",surname:"Niu",slug:"xiangli-niu",fullName:"Xiangli Niu"},{id:"343678",title:"Dr.",name:"Yan",surname:"Sun",slug:"yan-sun",fullName:"Yan Sun"},{id:"413978",title:"Mr.",name:"Yi",surname:"Mo",slug:"yi-mo",fullName:"Yi Mo"},{id:"413980",title:"Mr.",name:"Hua",surname:"Huang",slug:"hua-huang",fullName:"Hua Huang"}],corrections:null},{id:"77030",title:"The Role of Kisspeptin in the Ovarian Cycle, Pregnancy, and Fertility",doi:"10.5772/intechopen.98446",slug:"the-role-of-kisspeptin-in-the-ovarian-cycle-pregnancy-and-fertility",totalDownloads:192,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Kisspeptins are a group of neuropeptides with regulatory functions related to puberty, fertility, and reproduction. They are primarily produced by hypothalamic nuclei and are thought to regulate the activity of neurons that produce gonadotropin-releasing hormone. They are also expressed by placental syncytiotrophoblasts in developing pregnancies and are likely involved in the processes of trophoblast invasion and placentation. Similarly to beta-hCG, kisspeptins are found in maternal plasma during the first trimester of pregnancy and increase proportionately with gestational age. Because of their role in implantation, there is currently interest in the use of kisspeptins as minimally invasive biomarkers. It is suspected that maternal kisspeptin levels have diagnostic potential in identifying viable early pregnancies.",signatures:"Erin Ahart, Elaine Phillips, Michael Wolfe and Courtney Marsh",downloadPdfUrl:"/chapter/pdf-download/77030",previewPdfUrl:"/chapter/pdf-preview/77030",authors:[{id:"255491",title:"Dr.",name:"Courtney",surname:"Marsh",slug:"courtney-marsh",fullName:"Courtney Marsh"},{id:"350310",title:"Dr.",name:"Erin",surname:"Ahart",slug:"erin-ahart",fullName:"Erin Ahart"},{id:"352233",title:"Dr.",name:"Michael",surname:"Wolfe",slug:"michael-wolfe",fullName:"Michael Wolfe"},{id:"352234",title:"Ms.",name:"Elaine",surname:"Phillips",slug:"elaine-phillips",fullName:"Elaine Phillips"}],corrections:null},{id:"76694",title:"Effects of Different Types of Incubators on Embryo Development and Clinical Outcomes",doi:"10.5772/intechopen.97833",slug:"effects-of-different-types-of-incubators-on-embryo-development-and-clinical-outcomes",totalDownloads:256,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Main differences of incubators are humidity, temperature and gas control ways, which play important roles in regulating the steady state of culture media. In this study, we compared the effects of different types of incubators (air jacket incubators and water jacket incubators) on embryo development and clinical outcomes in human assisted reproduction. We found that temperature recovery time in air jacket incubators was significantly shorter than that in water jacket incubators. Although the O2 recovering time was also significantly shorter in air jacket incubators as compared with the water jacket incubator, no significant differences were observed in CO2 recovering time between two groups, which was also verified by pH recovering time of culture media. Besides, the temperature of culture medium in the dish covered with oil recovered more quickly in the air jacket incubators. However, there were no significant differences observed in the fertilization rate, Day 3 high-quality embryo rate, blastocyst rate, good blastocyst rate and clinical outcomes between two groups. These results indicate that the microenvironment, especially the temperature, in air jacket incubator recover faster than that in water jacket incubators, however, there were no significant differences in embryo development and clinical outcomes between two types of incubators.",signatures:"Ji Liu, Yan-Hua Zhou, Xiao-Xiao Wang, Ling-Xi Tong, Yan-Hong Li, Ling Liu, Zhi-Yan Xu and Hong-Hui Wang",downloadPdfUrl:"/chapter/pdf-download/76694",previewPdfUrl:"/chapter/pdf-preview/76694",authors:[{id:"352635",title:"Prof.",name:"Ji",surname:"Liu",slug:"ji-liu",fullName:"Ji Liu"},{id:"352642",title:"Dr.",name:"Hong-Hui",surname:"Wang",slug:"hong-hui-wang",fullName:"Hong-Hui Wang"},{id:"352644",title:"Mrs.",name:"Yan-Hua",surname:"Zhou",slug:"yan-hua-zhou",fullName:"Yan-Hua Zhou"},{id:"352645",title:"Mrs.",name:"Xiao-Xiao",surname:"Wang",slug:"xiao-xiao-wang",fullName:"Xiao-Xiao Wang"},{id:"352646",title:"Mr.",name:"Ling-Xi",surname:"Tong",slug:"ling-xi-tong",fullName:"Ling-Xi Tong"},{id:"352648",title:"Mr.",name:"Yan-Hong",surname:"Li",slug:"yan-hong-li",fullName:"Yan-Hong Li"},{id:"352649",title:"Dr.",name:"Ling",surname:"Liu",slug:"ling-liu",fullName:"Ling Liu"},{id:"352650",title:"Dr.",name:"Zhi-Yan",surname:"Xu",slug:"zhi-yan-xu",fullName:"Zhi-Yan Xu"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"2575",title:"Prolactin",subtitle:null,isOpenForSubmission:!1,hash:"338ea99a4e29b28d7463a976a301711b",slug:"prolactin",bookSignature:"György M. 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Vaz-Leal, María I. Ramos-Fuentes, Laura Rodríguez-\nSantos and M. Cristina Álvarez-Mateos",dateSubmitted:"June 28th 2016",dateReviewed:"August 12th 2016",datePrePublished:null,datePublished:"February 1st 2017",book:{id:"5372",title:"Eating Disorders",subtitle:"A Paradigm of the Biopsychosocial Model of Illness",fullTitle:"Eating Disorders - A Paradigm of the Biopsychosocial Model of Illness",slug:"eating-disorders-a-paradigm-of-the-biopsychosocial-model-of-illness",publishedDate:"February 1st 2017",bookSignature:"Ignacio Jauregui-Lobera",coverURL:"https://cdn.intechopen.com/books/images_new/5372.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"323887",title:"Prof.",name:"Ignacio",middleName:null,surname:"Jáuregui-Lobera",slug:"ignacio-jauregui-lobera",fullName:"Ignacio Jáuregui-Lobera"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"188555",title:"Prof.",name:"Francisco J.",middleName:null,surname:"Vaz-Leal",fullName:"Francisco J. Vaz-Leal",slug:"francisco-j.-vaz-leal",email:"fjvazleal@gmail.com",position:null,institution:null},{id:"188719",title:"Dr.",name:"María Cristina",middleName:null,surname:"Álvarez Mateos",fullName:"María Cristina Álvarez Mateos",slug:"maria-cristina-alvarez-mateos",email:"cristinaalvarezmateos@gmail.com",position:null,institution:null},{id:"195142",title:"Dr.",name:"Laura",middleName:null,surname:"Rodríguez Santos",fullName:"Laura Rodríguez Santos",slug:"laura-rodriguez-santos",email:"laura@unex.es",position:null,institution:null},{id:"195143",title:"Dr.",name:"María I",middleName:null,surname:"Ramos Fuentes",fullName:"María I Ramos Fuentes",slug:"maria-i-ramos-fuentes",email:"miramos@unex.es",position:null,institution:null}]}},chapter:{id:"52200",slug:"eating-disorders-as-new-forms-of-addiction",signatures:"Francisco J. Vaz-Leal, María I. Ramos-Fuentes, Laura Rodríguez-\nSantos and M. Cristina Álvarez-Mateos",dateSubmitted:"June 28th 2016",dateReviewed:"August 12th 2016",datePrePublished:null,datePublished:"February 1st 2017",book:{id:"5372",title:"Eating Disorders",subtitle:"A Paradigm of the Biopsychosocial Model of Illness",fullTitle:"Eating Disorders - A Paradigm of the Biopsychosocial Model of Illness",slug:"eating-disorders-a-paradigm-of-the-biopsychosocial-model-of-illness",publishedDate:"February 1st 2017",bookSignature:"Ignacio Jauregui-Lobera",coverURL:"https://cdn.intechopen.com/books/images_new/5372.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"323887",title:"Prof.",name:"Ignacio",middleName:null,surname:"Jáuregui-Lobera",slug:"ignacio-jauregui-lobera",fullName:"Ignacio Jáuregui-Lobera"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"188555",title:"Prof.",name:"Francisco J.",middleName:null,surname:"Vaz-Leal",fullName:"Francisco J. Vaz-Leal",slug:"francisco-j.-vaz-leal",email:"fjvazleal@gmail.com",position:null,institution:null},{id:"188719",title:"Dr.",name:"María Cristina",middleName:null,surname:"Álvarez Mateos",fullName:"María Cristina Álvarez Mateos",slug:"maria-cristina-alvarez-mateos",email:"cristinaalvarezmateos@gmail.com",position:null,institution:null},{id:"195142",title:"Dr.",name:"Laura",middleName:null,surname:"Rodríguez Santos",fullName:"Laura Rodríguez Santos",slug:"laura-rodriguez-santos",email:"laura@unex.es",position:null,institution:null},{id:"195143",title:"Dr.",name:"María I",middleName:null,surname:"Ramos Fuentes",fullName:"María I Ramos Fuentes",slug:"maria-i-ramos-fuentes",email:"miramos@unex.es",position:null,institution:null}]},book:{id:"5372",title:"Eating Disorders",subtitle:"A Paradigm of the Biopsychosocial Model of Illness",fullTitle:"Eating Disorders - A Paradigm of the Biopsychosocial Model of Illness",slug:"eating-disorders-a-paradigm-of-the-biopsychosocial-model-of-illness",publishedDate:"February 1st 2017",bookSignature:"Ignacio Jauregui-Lobera",coverURL:"https://cdn.intechopen.com/books/images_new/5372.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"323887",title:"Prof.",name:"Ignacio",middleName:null,surname:"Jáuregui-Lobera",slug:"ignacio-jauregui-lobera",fullName:"Ignacio Jáuregui-Lobera"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"6986",leadTitle:null,title:"Telomerase and non-Telomerase Mechanisms of Telomere Maintenance",subtitle:null,reviewType:"peer-reviewed",abstract:"This book, Telomerase and non-Telomerase Mechanisms of Telomere Maintenance, is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of biochemistry, genetics, and molecular biology. The book comprises single chapters authored by various researchers and edited by an expert active in the molecular biology research area. All chapters are individually complete but united under a common research topic. This publication aims to provide a thorough overview of the latest research efforts by international authors on biochemistry, genetics,and molecular biology, and open new possible research paths for further novel developments.\n\nA note from the publisher:\n\nIt is with great sadness and regret that we inform the contributing authors and readers of this book that the Editor, Dr Tammy A. Morrish, passed away during the publishing process of the book and before having a chance to see its publication. The book Telomerase and non-Telomerase Mechanisms of Telomere Maintenance was her first edited volume with us. Fruitful collaboration continued until her final days. We would like to acknowledge Dr Morrish's contribution to scientific publishing, which she made during years of dedicated work, and express our gratitude for her pleasant cooperation with us.",isbn:"978-1-78984-575-4",printIsbn:"978-1-78984-574-7",pdfIsbn:"978-1-83880-281-3",doi:"10.5772/intechopen.73734",price:119,priceEur:129,priceUsd:155,slug:"telomerase-and-non-telomerase-mechanisms-of-telomere-maintenance",numberOfPages:130,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"79b7d4e97e1e0722f4ce1309a2088be3",bookSignature:"Tammy A. Morrish",publishedDate:"April 1st 2020",coverURL:"https://cdn.intechopen.com/books/images_new/6986.jpg",keywords:null,numberOfDownloads:4439,numberOfWosCitations:0,numberOfCrossrefCitations:1,numberOfDimensionsCitations:3,numberOfTotalCitations:4,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 31st 2018",dateEndSecondStepPublish:"December 19th 2018",dateEndThirdStepPublish:"February 17th 2019",dateEndFourthStepPublish:"May 8th 2019",dateEndFifthStepPublish:"July 7th 2019",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"4 years",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:"Edited by",kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"275021",title:"Dr.",name:"Tammy A.",middleName:null,surname:"Morrish",slug:"tammy-a.-morrish",fullName:"Tammy A. Morrish",profilePictureURL:"https://mts.intechopen.com/storage/users/275021/images/system/275021.jpeg",biography:"Tammy A. Morrish’s scientific interests were focused on understanding mechanisms of non-LTR retrotransposition during DNA repair and telomere maintenance in tumors and primary cells. From 2012-2015, she was an Assistant Professor at the Department of Biochemistry and Cancer Biology at the University of Toledo. Her postdoctoral training was at Johns Hopkins University in the Department of Molecular Biology and Genetics where she received the Howard Temin Pathway to Independence Award from the NIH/NCI. Dr Morrish was also an American Society of Hematology Fellow Scholar and received funding from the Leukemia and Lymphoma Society. She received her Ph.D. from the University of Michigan in the Department of Human Genetics and was awarded a Rackham Predoctoral Fellowship and an Overall Excellence in Research and Service Award. She also had a B.A. in biochemistry from the University of Texas.\n\nA note from publisher:\n\nIt is with great sadness and regret that we inform the contributing authors and readers of this book that the Editor, Dr Tammy A. Morrish, passed away during the publishing process of the book and before having a chance to see its publication. The book Telomerase and non-Telomerase Mechanisms of Telomere Maintenance was her first edited volume with us. Fruitful collaboration continued until her final days. We would like to acknowledge Dr Morrish\\'s contribution to scientific publishing, which she made during years of dedicated work, and express our gratitude for her pleasant cooperation with us.",institutionString:"Independent Scientist",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"1",institution:null}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"47",title:"Cell Biology",slug:"biochemistry-genetics-and-molecular-biology-cell-biology"}],chapters:[{id:"70617",title:"Telomerase Structure and Function, Activity and Its Regulation with Emerging Methods of Measurement in Eukaryotes",slug:"telomerase-structure-and-function-activity-and-its-regulation-with-emerging-methods-of-measurement-i",totalDownloads:902,totalCrossrefCites:0,authors:[{id:"289144",title:"Prof.",name:"Prem Singh",surname:"Yadav",slug:"prem-singh-yadav",fullName:"Prem Singh Yadav"},{id:"296640",title:"Dr.",name:"Abubakar Muhammad",surname:"Wakil",slug:"abubakar-muhammad-wakil",fullName:"Abubakar Muhammad Wakil"}]},{id:"67277",title:"Telomerase in Space and Time: Regulation of Yeast Telomerase Function at Telomeres and DNA Breaks",slug:"telomerase-in-space-and-time-regulation-of-yeast-telomerase-function-at-telomeres-and-dna-breaks",totalDownloads:957,totalCrossrefCites:1,authors:[{id:"289209",title:"Ph.D.",name:"Raymund J.",surname:"Wellinger",slug:"raymund-j.-wellinger",fullName:"Raymund J. Wellinger"},{id:"289211",title:"BSc.",name:"Alexandra",surname:"Krallis",slug:"alexandra-krallis",fullName:"Alexandra Krallis"},{id:"294988",title:"Dr.",name:"Yulia",surname:"Vasianovich",slug:"yulia-vasianovich",fullName:"Yulia Vasianovich"}]},{id:"66947",title:"Telomere Formation Systems in Budding and Fission Yeasts",slug:"telomere-formation-systems-in-budding-and-fission-yeasts",totalDownloads:949,totalCrossrefCites:0,authors:[{id:"119877",title:"Dr.",name:"Kurt",surname:"Runge",slug:"kurt-runge",fullName:"Kurt Runge"},{id:"292616",title:"Ph.D.",name:"Julien",surname:"Audry",slug:"julien-audry",fullName:"Julien Audry"}]},{id:"68983",title:"Syndromes Associated with Telomere Shortening",slug:"syndromes-associated-with-telomere-shortening",totalDownloads:948,totalCrossrefCites:0,authors:[{id:"289022",title:"Mr.",name:"Snehasish",surname:"Nag",slug:"snehasish-nag",fullName:"Snehasish Nag"}]},{id:"67048",title:"Telomeres and Telomerase Activity in the Human Placenta",slug:"telomeres-and-telomerase-activity-in-the-human-placenta",totalDownloads:684,totalCrossrefCites:0,authors:[{id:"90383",title:"Prof.",name:"Marie",surname:"Jirkovská",slug:"marie-jirkovska",fullName:"Marie Jirkovská"},{id:"289686",title:"Prof.",name:"Marie",surname:"Korabečná",slug:"marie-korabecna",fullName:"Marie Korabečná"},{id:"295751",title:"MSc.",name:"Soňa",surname:"Laššáková",slug:"sona-lassakova",fullName:"Soňa Laššáková"}]}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"220812",firstName:"Lada",lastName:"Bozic",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/220812/images/6021_n.jpg",email:"lada@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. 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About 80% of the energy consumed worldwide come from conventional energy sources, where more than 50% is used by the industry being a large part of this demand for the generation of heat industrial process [1, 2]. However, the use of fossil fuels to satisfy this demand has led to severe environmental impacts, which together with the decline of this resource has led to global energy policies focus on replacing fossil fuels with sustainable energy sources. The use of solar thermal systems could help to reduce CO2 emissions and other pollutants in the atmosphere.
\nSolar energy is one of the renewable energies that attract more attention due to its abundance, cleanliness, and the fact that it does not generate any pollution [3]. On the other hand, in the industries exist several processes that require thermal energy with temperature range between 60 and 250 °C for heat process generation; industries such as dairies, plastics, canned food, textile, paper, etc. employ this kind of energy to process such as drying, sterilizing, cleaning, evaporation, steam and conditioning warehouses space for both heating and cooling [4]. This energy could be easily supplied by solar collectors using photothermal conversion. The thermal storage process is used to supply the required power loading when there is no sunlight. Amongst the middle-temperature solar collectors are the parabolic trough, Fresnel, compound parabolic collectors (CPCs) and evacuated tubes. In this work, we consider parabolic trough solar concentrators (PTCs) that could yield the heat within the temperature between 90 and 400 °C. Parabolic trough solar concentrators (PTCs) are one of the most mature technologies developed in this area [5]. Nevertheless, the use of this technology entails certain difficulties because of a large number of operational and environmental parameters. This becomes an extremely complicated study on these systems, creating complex nonlinear equations for compression, which results in the employment of sophisticated control systems to operate and optimize the PTC performance, in order to maximize its cost-benefit during the operation. The modeling and simulation of these systems should take into account the collector, the thermal load, and the losses to the environment and the power auxiliary supply.
\nIn the last decades, in the area of renewable energy, the employ of computational intelligence methods such as artificial neural networks (ANN) has been rising to perform modeling and optimization process [6] because all the information based on renewable energy systems is very volatile and it has too much noise and also the behavior does not present a linear trend. In recent years, one of the most promising approaches for modeling and control of the highly nonlinear processes is the use of recurrent neural network. For most applications on time series forecasting, recurrent neural network (RNN) using the back-propagation learning algorithm has presented good results. However, this learning law is based on the gradient descent method and its convergence speed could not meet the requirements when fast responses are needed. Another well-known training algorithm is the Levenberg-Marquardt whose main disadvantage is that it does not guarantee finding the global minimum and its learning speed could be slow since it depends on the initialization values. To overcome the learning speed and uncertainties issues, recently, the extended Kalman Filter (EKF)-based algorithms have been implemented to train neural networks. With the EKF-based algorithm, the learning convergence is improved [6]. Using the EKF training on recurrent neural networks drives to improve results mostly in control, identification and predictions applications where the critical variables are subject to uncertainties and unmodeled dynamics. However, the EKF training requires the heuristic selection of some design parameters, which is not always an easy task.
\nThis chapter is focused on presenting the methodology used to conduct the process of modeling the thermal efficiency of an array of PTCs, in order to bring the system to optimal operating conditions through a desired efficiency by using ANN. The chapter is divided into five sections: Section 2 describes the experimental system composed by parabolic trough solar concentrations; Section 3 details the artificial neural network as modeling tool; Section 5 presents the development of the inverse modeling for optimization; and Section 6 describes the conclusions.
\nThe experimental system corresponds to a low enthalpy steam generation plant built according to the ASHRAE 93-1986 (RA 91) standard [7]; it is composed by:
\nthree PTCs (with 90° rim angle) with a length of 2.44 m and an aperture of 1.06 m;
two storage thermic tanks of 120 L capacity which cover two functions: the first is to preheat the water for the characterization of PTC employing electrical resistances inside the tanks (the first with 3 kW and second with 6 kW) and the second is to store the energy produced by PTCs;
a hydraulic circuit and two centrifugal water pumps of ½ HP is employed to recirculate the preheated water to PTCs and then return it to the tanks;
a set of sensors consisting in a Hedland HB2800 flow meters, pressure and temperature meters at the storage thermic tanks outlet, such as pressure and temperature meters at the outlet of PTCs.
For the measurement of environmental conditions, a pyranometer, an anemometer and temperature sensors were employed. Figure 1 shows the diagram of the experimental system.
\nOperation diagram of parabolic solar concentration experimental system.
A parabolic trough solar concentrator consists of a shaped channel sheet with parabolic cross-section whose surface must have a high reflectance value (
Parabolic trough solar concentrator.
Rim angle ( | \n|||
---|---|---|---|
40° | \n2 | \n1.5795 | \n1.4927 | \n
50° | \n2 | \n1.7404 | \n1.5199 | \n
60° | \n18 | \n14.420 | \n5.6055 | \n
70° | \n2 | \n2.3000 | \n1.5974 | \n
80° | \n2 | \n2.7846 | \n1.6485 | \n
90° | \n2 | \n2.8284 | \n2.4142 | \n
Constant values respect the rim angle.
One of the most practical ways to calculate the dimensions of a PTC by considering the curve length
where the coefficients
Another important parameter related to the rim angle (
where
The optical efficiency (
where
There are two types of errors associated with the parabolic surface: random and no random. The first type of errors is apparent changes in the sun width, scattering effects caused by random slope errors and associated with the reflective surface; these can be represented by normal probability distributions. The second class of errors depends on the manufacturing and operation of the collector. These errors are due to the reflector profile imperfections, misalignment and receiver location errors [11]. Random errors are modeled statistically to calculate the standard deviation of the distribution of the total energy reflected at normal incidence [12]:
\nwhere
The experimental evaluation for thermal performing of PTC is realized according to the ASHRAE 93-1986 (RA 91) standard [7]. This standard provides a widely known method to obtain the thermal efficiency of solar energy collector that uses single phase fluids, in order to be compared with the similar solar collectors [13]. Therefore according to the standard, the thermal instantaneous efficiency (
where
On the other hand, the PTC thermal efficiency (
where (Δ
Artificial neural networks (ANN) are adaptive systems developed in the form of computational algorithms or electrics circuits, which are inspired in the biological neuron system operation. An ANN is composed of a large number of interconnected units called neurons that have a certain natural tendency for learning information from the outside world [14]. These structures are used to estimate or approximate functions that may depend on a lot of variables, which are generally unknown reason for why the ANN have been used in many practical applications such as pattern recognition, estimation of series time and modeling of nonlinear processes [15].
\nA model of ANN can be seen as a black box to which is entered a database composed of a series of input variables; each of these input variables is assigned an appropriate weighting factor called weight (
Artificial neuron with
Recurrent neural network.
Among the many existing ANN models the most widely used is known as multi-layer perceptron (MLP) [17], which is used to solve multivariable problems by nonlinear equations using a process called training. The training process is performed through specific learning algorithms, where the most widely used is known as back-propagation through time [18]. The architecture of an MLP is usually divided into three parts known as: input layer, hidden layer and output layer. During the training process, the MLP learns from past errors to get a model that describes as closely as possible to the nonlinear phenomenon. To carry out this, during the training phase they adapt the weight and bias parameters until the approximation error is minimized [19].
\n\nA recurrent neural network responds temporally to an external input signal where the feedback allows the RNN to have a representation in state space; this versatility makes them convenient for diverse applications for modeling, optimization and control. The order in an RNN refers to the form in which the neuron activation potential is defined [20]. When the local activation potential is combined with products of signals coming from of the feedback or when products are made between the later and the external input signals to the network, a neural network of order emerges, where the order represents the number of signals that are multiplied. In this work, in order to carry out modeling of the process, a high order recurrent neural network is designed. The structure is composed by an input vector, one hidden layer and an output layer composed of just one neuron with a linear activation function. In Figure 4, the designed recurrent neural network architecture is depicted.
\n\nAccording to Figure 4,
For the set of weights, we construct a weight vector that will be estimated by means of the Kalman Filtering. The Kalman Filtering (KF) algorithm was first designed as a method to estimate the state of a system under noise on the process and on the measurement. Consider a linear, discrete-time dynamical system described by\n
Eq. (7) is known as the process equation;
where
The
where NW is the total number of neural network weights and o is the total number of outputs.
\nOptimization by neural network methodology.
In order to solve the optimization problem proposed, a computational intelligence methodology is developed. The proposed approach is divided into two parts: first is the generation of a mathematical model by RNN and the second part is responsible for performing inverse neural network for the optimization process. Figure 5 displays the methodology divided into three steps: (i) the first step consist in generate a database with the most important parameters that could affect the desired output, which is schematized in Figure 6, which in our case is the thermal efficiency, (ii) in the second step an RNN model is trained to obtain the best approximation error that relates the inputs with desirable outputs; (iii) in the last step one of the RNN inputs is selected to function as a control variable to perform the optimization process by an inverse neural network architecture.
\nNeural network architecture for the mathematic model of thermal efficiency.
Parameters | \nMin | \nMax | \nUnits | \n
---|---|---|---|
Input | \n|||
Operational variables | \n|||
Inlet flow temperature (Tin) | \n27.75 | \n86.30 | \n[°C] | \n
Outlet flow temperature (Tout) | \n34.70 | \n100.2 | \n[°C] | \n
Flow working fluid (Fw) | \n0.94 | \n6.11 | \n[L/min] | \n
Environmental variables | \n|||
Ambient temperature (Tamb) | \n24.26 | \n33.99 | \n[°C] | \n
Direct solar radiation (Gb) | \n830.0 | \n1014 | \n[W/m2] | \n
Wind velocity (Vw) | \n0.95 | \n3.98 | \n[m/s2] | \n
Output | \n\n | \n | \n |
Thermal efficiency (Eff) | \n0.16 | \n0.63 | \n[–] | \n
Parameters employed at the ANN prediction model.
Experimental database provided by Jaramillo et al. [13], consists of different
The development of predictive mathematical model of the experimental database was divided into two processes; the main process (in these case 80%) was destined to RNN learning and testing process and the other part (20%) was employed for the validation of the results, in order to obtain a good representation of the data distribution.
\nAt the training process, a normalized database was entered into a MLP architecture, where the number of neurons at the input and output layers was given by the number of input and output variables in the process, respectively. The Kalman Filter training algorithm in Eq. (9) was employed to obtain the optimum weights and bias for the RNN model as the one displayed in Figure 4.
\n\nThermal efficiency validation. (a) Experimental thermal efficiency not included at training and (b) simulate thermal efficiency from RNN model.
To validate the MLP model, a comparison was carried out employing the data not included in the training process. The output values comparison (thermal efficiency) was made in function of two variables, the heat loss parameter (Δ
Once generated the desired mathematical model and proven effective, an optimization process is applied. To perform the optimization analysis, an input variable must be selected as control input. The selected variable in the present application was the water flow since it can be manipulated and quickly impact the system behavior. For the optimization process, the output generated by the ANN model (thermal efficiency) acts as input to a process modeled from experimental values, generating as output a control variable that minimizes the difference for the desired thermal efficiency. Figure 8 displays the inverse ANN architecture.
\nInverse artificial neural network.
The aim of this chapter was to design an artificial neural network algorithm to predict the thermal performance of a parabolic trough concentrator, in order to develop a new approach for the estimation of the optimal operation condition of PTCs for a desired efficiency. A recurrent neural network was applied to model the nonlinear characteristics of the process with an excellent approximation of the thermal efficiency.
\nWorldwide, cardiovascular diseases (CVDs) are leading morbidity and mortality burdens. It has been estimated that 17.9 million people die from CVDs each year, representing 32% of all global deaths. The World Health Organization (WHO) defines CVDs as a group of disorders that include coronary artery disease (CAD), cerebrovascular disease, peripheral arterial disease, rheumatic heart disease, congenital heart disease, deep vein thrombosis, and pulmonary embolisms [1]. The world’s biggest killer of all is ischemic heart disease, or CAD, responsible for 16% of the world’s total deaths [2]. According to a statistical report published in 2020, the global prevalence of CAD was estimated at 1655 per 100,000 people and is predicted to exceed 1845 by 2030 [3]. In the United States, CAD accounts annually for approximately 610,000 deaths and costs more than 200 billion dollars for healthcare [4].
As most CAD patients are elderly and have multiple comorbidities, they need to use medication combinations over long periods, either for treatment or prophylaxis [5, 6]. One of the major strategies used for preventing CAD is antiplatelet therapy, and the most widely used antiplatelet agent tested is aspirin [6]. However, the therapeutic window of CAD drugs is very small, and inappropriate use can lead to many consequences that affect patients’ health. For instance, aspirin plays a role in reducing the risk of cardiovascular events, but it also increases the risk of bleeding, the most common risk being gastrointestinal bleeding [7, 8]. Therefore, despite the benefit of the drug, it also causes problems that adversely affect health. Old age, polypharmacy, and comorbidities are significant risk factors for developing drug-related problems (DRPs) [9, 10].
A drug-related problem (DRP) has been defined as “an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes” [11]. DRPs can have many negative consequences for patients and society, such as decreased quality of life for patients, increased hospitalization rates, prolonged hospital stays, increased overall healthcare costs, and even increased risk of morbidity and mortality [12, 13, 14]. For example, warfarin and oral antiplatelet agents have been reported to be implicated in nearly 50% of emergency hospital admissions of elderly Americans [15].
A further serious consequence of DRPs is the economic burden. DRPs accounted for a waste of $528.4 billion, equivalent to 16% of total US healthcare expenditures [16]. In studies of CVDs, the prevalence of patients with at least one DRP varied from nearly 30% to more than 90% [17, 18, 19]. A systematic review of DRPs concluded that the drugs most commonly involved were cardiovascular drugs [12]. In CAD patients, the drugs most implicated in DRPs were beta-blockers (BBs) (34.4%), followed by angiotensin-converting enzyme inhibitors (ACEI) (24.8%), statins (16.5%), and antithrombotics (13.1%) [20]. Different drugs are often associated with several different common DRPs. To illustrate, BBs were frequently involved in ineffective drug therapy, too low dosage, and the need for additional drug therapy, while ACEIs were commonly associated with too low dosage [20]. Studies in Ethiopia, Vietnam, and Spain have estimated that the mean numbers of DRPs for each patient with CAD were about 0.75, 0.92, and 1.51, respectively [17, 18, 21]. The prevalence of CAD patients with at least one DRP was 61.1% [21]. These statistics are relatively high and represent an alarming frequency of DRPs in patients with CAD. DRPs must therefore be noticed and recognized by healthcare professionals.
This chapter separates DRPs in CAD patients into 5 common subtypes: drug selection, dose selection, adverse drug-drug interactions (DDI), patient adherence, and cost issues. We also discuss determinants that increase the ratio of DRPs, and list interventions to limit their prevalence. Our goal is to provide health care providers with an overview of the extent of DRPs and their common types; these must be considered to ensure the safety and effectiveness of drug therapy.
Inappropriate drug selection is a common type of DRP in patients with CAD; it mainly includes ineffective drug therapy, a need for additional drug therapy, and prescription of drugs with contraindications. In an Ethiopian study, O.A. Abdela et al. found that, globally, the most common category of DRPs was inappropriate drug selection for CVDs (36.1%), and in particular for CAD (46.6%) [17]. Studies in Spain and Vietnam showed the prevalence of inappropriate drug selection of 19.4% and 3.5% for CAD patients [18, 21]. Inappropriate drug selection can have several causes. A study in Indonesia found that clinicians’ critical factor influencing statin prescribing was their lack of awareness of specific details in current guideline recommendations. Although clinicians generally know the guidelines, they remain uncertain about how to determine the level of total cholesterol in combination with other cardiovascular risk factors like diabetes and hypertension [22].
Ineffective drug therapy occurs when the drug product used is not effective for the treatment of the medical condition [23]. A need for additional drug therapy exists when the medical condition requires additional drugs to achieve synergistic or additive effects [23]. A study by A.W. Tsige et al. in Ethiopia showed that among DRPs, the prevalence of need for additional drug therapy was 30.53%, and ineffective drug therapy was 26.9% [24]. In the Netherlands, J. Tra et al. conducted a study of prescriptions for patients discharged after CADs. They found that the angiotensin-converting enzyme inhibitor, one of the most important drugs in the prescribing guideline, was often missing (21.2%) [25]. In patients who have had acute coronary syndromes, it is vital to follow prescribing guidelines for secondary prevention to avoid further serious cardiovascular events. For example, according to a study on the prescription of secondary preventative cardiovascular therapies for non-ST elevation myocardial infarction (NSTEMI), adenosine-diphosphate receptor antagonist prescribing rates had significantly increased (76%) [26]. On the other hand, a study evaluating patient adherence to prescription guidelines after acute coronary syndrome indicated that adherence to lipid-lowering therapy was the lowest. The percentage of adherence to the criterion: ‘Patient regardless of lipid level is prescribed a high-intensity statin either atorvastatin 40–80 mg or rosuvastatin 20–40 mg’, was only 16.7% in the post-ST elevation myocardial infarction group, and 33.3% in the post-non-ST elevation acute coronary syndrome group [27]. A Canadian study found that only 61% of patients with stable coronary artery disease received optimal drug therapy involving concurrent use of β-blockers, ACE inhibitor/angiotensin receptor blockers, and statins [28]. Failure to prescribe drugs that should be indicated for treatment or prevention reduces the effectiveness of treatment. For example, after myocardial infarction, patients who have conditions like heart failure, pulmonary disease, and older age are often prescribed beta-blockade therapy, which is ineffective. However, patients without these conditions benefit from such therapy [29]. Ineffective drug therapy and a need for additional drugs can lead to increased medical costs, potential drug interactions, and decreased patient adherence [30].
Medicines that cause harm to the patient or negative interaction with a combination drug are called contraindicated medicines [31]. In a multicenter study in France, research on physicians’ acceptance of pharmacists’ daily routine interventions revealed that contraindication was the most identified DRP (21.3%) [32]. However, studies on CAD patients in Vietnam and Ethiopia showed that the prevalence of contraindicated medicines leading to DRPs was only approximately 0% and 2%, respectively [17, 21]. Therefore, in the latter two countries, among CAD patients, this issue is less common than in other DRPs.
Increasing the role of clinical pharmacists and the application of prescription management software in the prescribing process to check contraindication and interaction could be effective interventions to minimize such problems. For patients to be treated with appropriate drugs, clinicians should follow treatment guidelines and update their recommendations. In addition, the patient’s response to treatment should be monitored by clinical examination and tests, and if necessary, a change of drug to suit the patient’s condition.
Inappropriate dose selection includes both too high and too low [23]. A study in Spain by P. Gastelurrutia et al. found that inappropriate dose selection was one of the most frequently identified DRPs, with a prevalence of 22% [33], and a study in Turkey by Urbina, Olatz et al. found inappropriate dose selection in CAD patients to have a prevalence of 41% [18]. In a Vietnamese study by T.T.A. Truong et al., this prevalence was 22.2% [21]. Inappropriate dose selection can take place for several reasons. For example, ignoring comorbidities that affect the pharmacodynamics of a drug, such as hepatic or renal failure, can lead to inappropriate dose selection. Patients with renal and hepatic dysfunction require lower doses; otherwise, failure of excretion or breakdown of the drug can cause toxicity [34]. Furthermore, differing characteristics of patients, such as weight and body mass index, can make a prescribed dose too low or high for the patient’s needs.
Sometimes high dosage prescription was considered when the duration of drug therapy was regarded as too long, possibly leading to unwanted side-effects for the patient [23]. In Spain and Vietnam, patients with CAD had a prevalence of high dose prescriptions of 8.6% and 0.1%, respectively [18, 21]. A study by Simon B. Dimmitt et al. had found that statin doses around an estimated effective dose of 50 (ED50) could reduce myocardial infarction (25%) and mortality (10%). However, the high dosage can also increase adverse events: myopathy was shown to increase 29-fold, and liver dysfunction as much as 9-fold [35]. A national study in America reported that overdoses led to nearly two-thirds of emergency hospitalizations [15]. Because the therapeutic window of CVD drugs in general, and CAD drugs in particular, is very small, an overdose is very severe and can lead to death. For example, an indirect sympathomimetic overdose can result in tachycardia, hypertension, stroke, and acute myocardial infarction [36]. Furthermore, in patients with renal dysfunction or renal failure, drugs that are eliminated by the kidney should be dosed proportionally according to creatinine clearance [37].
In contrast, a too low dosage means that the dose is not sufficient to produce the desired response [23]. In Spain and Vietnam, DRPs of patients with CAD occurring due to low dosage prescriptions were 7.9% and 22.1%, respectively [18, 21]. Taking too low a dose fails to achieve the desired therapeutic goal, increasing the possibility of cardiovascular events [23]. A systematic overview of randomized trial studies in patients with risk of cardiovascular disease found that a dose of aspirin between 75 and 150 mg daily gives adequate prophylaxis; doses lower than 75 mg daily are less effective [38]. A study was conducted in patients with acute coronary syndrome after stent implantation to compare the efficacy of different doses of rosuvastatin [39]. This study concluded that high doses of rosuvastatin could postpone ventricular remodeling, decrease the prevalence of adverse events, and significantly improve long-term prognosis.
To limit problems related to dose selection, doctors need to pay attention to each patient’s condition, comorbidities, and characteristics affecting drug pharmacokinetics and monitor and adjust drug dose depending on the tolerance of the individual patient. In addition, the clinical pharmacist can help to calculate the appropriate drug dose for each patient. Furthermore, the application software should be developed to assist in dose calculation for special populations like elderly patients or liver and/or kidney disease patients.
Adverse drug-drug interactions (DDIs) occur when drug interaction leads to undesirable reactions that are not dose-related [23]. In patients with heart failure in Ethiopia, DDIs were the most common cause of DRPs, with a prevalence of 27.3% in 2020 and 33.4% in 2021 [24, 40]. However, a study in Taiwan found DDIs to be the second most common DRP (29.6%) [41]. In patients with CAD in Ethiopia and Vietnam, DDIs had prevalences of 21.2% and 19.3%, respectively [21, 40]. Often, patients with CAD have to take multiple medications for a long time [5], and other drugs must frequently be used to treat co-morbidities. However, the greater the number of drugs, the greater the risk of drug-drug interactions [5].
The most common DDI found in patients with heart failure was the combined use of spironolactone and digoxin, possibly resulting in increased digoxin toxicity [40]. A systematic review of secondary prevention of adverse ischemic events found that a regimen including aspirin plus clopidogrel led to a significantly higher rate of hemorrhagic events than other regimens (aspirin alone, plus ticlopidine or cilostazol, etc.) [6]. Another common drug-drug interaction between clopidogrel and proton pump inhibitors (PPIs) in patients with CAD. Clopidogrel is a P2Y12 receptor inhibitor and one of the two components of dual antiplatelet therapy [42]. PPIs are recommended for patients on dual antiplatelet therapy with a history or high risk of gastrointestinal bleeding [43]. Adverse drug interactions reduce the effectiveness of treatment. For example, some PPIs, such as omeprazole and esomeprazole, reduce the antiplatelet effect of clopidogrel by inhibiting the CYP2C19-mediated conversion of clopidogrel to the active metabolite in the liver [44]. In addition, concomitant clopidogrel-PPI therapy appears to increase the risk of major adverse cardiovascular events [45]. Meanwhile, PPIs such as lansoprazole and dexlansoprazole have been found to have less effect, and pantoprazole and rabeprazole do not affect the metabolism of clopidogrel [46, 47]. Therefore, one of the four PPIs: pantoprazole, rabeprazole, lansoprazole, or dexlansoprazole, should be chosen, and omeprazole and esomeprazole should be avoided in patients requiring a combination of clopidogrel and PPI.
To limit adverse drug-drug interactions, clinicians can use drug interaction testing tools with the assistance of a clinical pharmacist. If a severe drug-drug interaction occurs, an alternative drug should be considered. Furthermore, an online drug interaction checker (Drug.com, Medscape, etc.) should be used for checking before prescribing to patients.
Poor patient adherence is another common DRP in coronary artery disease. Nonadherence involves the failure of a patient to take medications appropriately due to personal factors [23]. Several studies have indicated that roughly 20% and more than 50% of CAD patients are non-adherent to prescribed medications [48, 49, 50]. Many factors can affect patient adherence to treatment: lack of motivation, failure to understand instructions, forgetfulness, the complexity of the regimen, polypharmacy, multiple daily doses, adverse side effects, high cost, failure to initiate treatment before discharge, and the physician’s lack of knowledge of clinical indicators for the use of medications [51, 52]. In addition, older people have many unique difficulties that contribute to poor adherence [52], one of the main factors being forgetfulness [53]. Some studies indicate that long-term therapy involving CAD prophylaxis may decrease adherence. A Swedish study reported that the adherence rate in CAD patients after discharge rapidly decreased within 2 years. Statin, aspirin, and clopidogrel adherence rates decreased from 91.7% to 56.1%, 93.2% to 61.5%, and 81.9% to 39.4% respectively, 2 years after discharge [54].
Patient adherence greatly contributes to the success of treatment and secondary prevention strategies in CAD patients. Good adherence to evidence-based medication regimens, including β-blockers, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, antiplatelet drugs, and statins, has been shown to be associated with decreased risk of all-cause mortality (risk ratio 0.56; 95% confidence interval: 0.45–0.69), cardiovascular mortality (risk ratio 0.66; 95% confidence interval: 0.51–0.87), and cardiovascular hospitalization/myocardial infarction (risk ratio 0.61; 95% confidence interval: 0.45–0.82) [55]. In contrast, poor adherence can lead to major cardiovascular events, including death [56]. In Turkey, during one-year follow-up treatment, patients with acute coronary syndrome were found to have low adherence to statin therapy (17.8%) [57]. According to a study by C.A. Jackevicius et al. in the Canadian population, patients who did not use all of their discharge medications after acute coronary syndrome had an increased risk of death at 1 year [56]. The death rates among high-adherence and low-adherence were respectively 2310/14,345 (16%), and 261/1071 (24%) (adjusted hazard ratio, 1.25; 95% confidence interval, 1.09–1.42;
Drug counseling upon discharge and post-discharge follow-up may increase adherence [56]. When patients know their medical condition and the benefits of prescription medications, they are more motivated to take them exactly as recommended [59]. Moreover, appropriate prescribing upon discharge should be encouraged to improve patient adherence [52]. Prescribing fixed-dose combination pills instead of using multiple single drugs also helps to enhance adherence [60, 61]. A systematic review in low- and middle-income countries demonstrated considerable variation in nonadherence to antihypertensive medication [62]. Due to the overload of healthcare systems, especially in these low- and middle-income countries and during the COVID-19 pandemic, clinicians have too little time to educate patients [63]. A systematic review of 67 countries found that about half of the world’s population spends 5 min or less with their primary care physicians [64]. Therefore, more attention should be paid to the role of the clinical pharmacist. Clinical pharmacists can help patients understand the benefits of each medication they take, the timing and frequency of administration, and signs of side effects; they can also encourage and monitor patient adherence. A systematic review of medication adherence interventions showed significant reductions in mortality risk among heart failure patients (relative risk, 0.89; 95% CI, 0.81, 0.99). A bulk of these interventions utilized medication education (s = 50) and disease education (s = 48) [65].
Medical costs for CAD have increased dramatically in recent years and are expected to rise even more [66]. The result is an increased economic burden for patients themselves and countries. For example, hospital admission for acute myocardial infarction requiring percutaneous coronary intervention costs an average of $20,000 [67]. In the USA, it has been calculated that in 2016 DRPs wasted $528.4 billion, equivalent to 16% of the total US healthcare expenditure for that year [16]. Furthermore, the cost of informal healthcare for CAD alone was estimated at $1 billion and projected to increase to $1.9 billion by 2035 [68]. According to M. Guerro-Prado et al., cost issues accounted for up to 6.5% of all DRPs. Unnecessary and unnecessarily expensive treatments were the main reasons for such problems [69]. Furthermore, cost issues are also related to physicians’ prescriptions. A Chinese national study among 3362 primary healthcare sites showed that expensive medications were more likely to be prescribed than less costly alternatives, thus contributing to high medication costs [70]. Increased medication costs may likely reduce patient adherence and negatively affect their healthcare [51, 71]. Patients’ discontinuation of medication therapies affects their treatment outcomes and increases the occurrence of adverse cardiovascular events [56]. To treat these events, the costs of treatment become even greater.
WHO has listed some interventions that may reduce costs. Such interventions include providing information; government communication is vital to raise public awareness of the importance of reducing cardiovascular risk factors. Further efforts to reduce medical costs include early disease detection, optimal treatment according to recommendations, and close patient management to limit complications, hospitalization, and death. Also recommended for patients with coronary artery disease are lifestyle changes that enhance the effectiveness of treatment, thereby reducing the number of drugs needed [72]. To further avoid adding to treatment costs, clinicians should avoid prescribing unnecessary extra drugs [70]. Finally, it is necessary to encourage individuals to participate in health insurance to reduce the financial burden of illness [72].
DRPs are a global problem, causing adverse consequences in cardiology in particular and medicine in general. Drug selection, dose selection, adverse drug-drug interactions, and patient adherence are the most common categories involved in DRPs. Inability to control DRPs can diminish healthcare outcomes and increase the prevalence of adverse cardiovascular events, and DRPs can also inhibit economic growth due to medication costs. To minimize the negative impacts of DRPs we propose several key solutions: (1) appropriate prescribing according to guidelines, (2) enhancing the role of clinical pharmacists in the identification and intervention of DRPs, and (3) developing tools to check for drug interactions and contraindications. More effective definition and recognition of DRPs and application of relevant interventions can help to limit these global problems.
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Due to rapid depletion of agricultural areas and soil quality by means of ever-increasing population and an excessive addition of chemical fertilizers, a rehabilitated attention is a need of the hour to maintain sustainable approaches in agricultural crop production. Biochar is the solid, carbon-rich material obtained by pyrolysis using different biomasses. It has been widely documented in previous studies that, the crop growth and yield can be increased by using biochar. This chapter exclusively summarizes the properties of biochar, its interaction with soil microflora, and its role in plant growth promotion when added to the soil.",book:{id:"7305",slug:"biochar-an-imperative-amendment-for-soil-and-the-environment",title:"Biochar",fullTitle:"Biochar - An Imperative Amendment for Soil and the Environment"},signatures:"Jyoti Rawat, Jyoti Saxena and Pankaj Sanwal",authors:null},{id:"46355",doi:"10.5772/57469",title:"Phytoremediation of Soils Contaminated with Metals and Metalloids at Mining Areas: Potential of Native Flora",slug:"phytoremediation-of-soils-contaminated-with-metals-and-metalloids-at-mining-areas-potential-of-nativ",totalDownloads:8550,totalCrossrefCites:14,totalDimensionsCites:86,abstract:null,book:{id:"3854",slug:"environmental-risk-assessment-of-soil-contamination",title:"Environmental Risk Assessment of Soil Contamination",fullTitle:"Environmental Risk Assessment of Soil Contamination"},signatures:"Paulo J.C. Favas, João Pratas, Mayank Varun, Rohan D’Souza and\nManoj S. Paul",authors:[{id:"169746",title:"Dr.",name:"Paulo",middleName:null,surname:"Favas",slug:"paulo-favas",fullName:"Paulo Favas"},{id:"169747",title:"Dr.",name:"Manoj",middleName:"Stephen",surname:"Paul",slug:"manoj-paul",fullName:"Manoj Paul"},{id:"169952",title:"Dr.",name:"Joao",middleName:null,surname:"Pratas",slug:"joao-pratas",fullName:"Joao Pratas"},{id:"169953",title:"Dr.",name:"Mayank",middleName:null,surname:"Varun",slug:"mayank-varun",fullName:"Mayank Varun"},{id:"169954",title:"Dr.",name:"Rohan",middleName:null,surname:"D'Souza",slug:"rohan-d'souza",fullName:"Rohan D'Souza"}]},{id:"61845",doi:"10.5772/intechopen.77987",title:"Montmorillonite: An Introduction to Properties and Utilization",slug:"montmorillonite-an-introduction-to-properties-and-utilization",totalDownloads:5469,totalCrossrefCites:43,totalDimensionsCites:76,abstract:"Clay mineral is an important material available in nature. With an increasing understanding of clay structure, montmorillonite is realized viable for an enhanced performance in a variety of materials and products in the areas of catalysis, food additive, antibacterial function, polymer, sorbent, etc. Significant development in the use and application of montmorillonite is seen in recent time. This chapter provides an overview of montmorillonite, structure, and properties and particularly discusses its recent utilization in important materials. Montmorillonite is introduced in terms of its natural sources, chemical structure, physical and chemical properties, and functional utilization. The important physical and chemical properties are summarized as particle and layered structure, molecular structure and cation exchange effect, barrier property, and water sorption. This is followed by the important functional utilizations of montmorillonite based on the effects of its chemical structure. The important functional utilization of montmorillonite includes food additive for health and stamina, for antibacterial activity against tooth and gum decay, as sorbent for nonionic, anionic, and cationic dyes, and the use as catalyst in organic synthesis. The environment concerns, to date, do not indicate the adversity for particles used as additive. Studies will be useful which are clearly based on any montmorillonite structure to describe environmental effects.",book:{id:"6561",slug:"current-topics-in-the-utilization-of-clay-in-industrial-and-medical-applications",title:"Current Topics in the Utilization of Clay in Industrial and Medical Applications",fullTitle:"Current Topics in the Utilization of Clay in Industrial and Medical Applications"},signatures:"Faheem Uddin",authors:[{id:"228107",title:"Prof.",name:"Faheem",middleName:null,surname:"Uddin",slug:"faheem-uddin",fullName:"Faheem Uddin"}]}],mostDownloadedChaptersLast30Days:[{id:"46032",title:"Soil Contamination, Risk Assessment and Remediation",slug:"soil-contamination-risk-assessment-and-remediation",totalDownloads:13896,totalCrossrefCites:22,totalDimensionsCites:60,abstract:null,book:{id:"3854",slug:"environmental-risk-assessment-of-soil-contamination",title:"Environmental Risk Assessment of Soil Contamination",fullTitle:"Environmental Risk Assessment of Soil Contamination"},signatures:"Muhammad Aqeel Ashraf, Mohd. Jamil Maah and Ismail Yusoff",authors:[{id:"25185",title:"Dr.",name:"Muhammad Aqeel",middleName:null,surname:"Ashraf",slug:"muhammad-aqeel-ashraf",fullName:"Muhammad Aqeel Ashraf"},{id:"101988",title:"Dr.",name:"Ismail",middleName:null,surname:"Yusoff",slug:"ismail-yusoff",fullName:"Ismail Yusoff"},{id:"169931",title:"Prof.",name:"Mohd Jamil",middleName:null,surname:"Maah",slug:"mohd-jamil-maah",fullName:"Mohd Jamil Maah"},{id:"169932",title:"Dr.",name:"Ng Tham",middleName:null,surname:"Fatt",slug:"ng-tham-fatt",fullName:"Ng Tham Fatt"}]},{id:"71931",title:"Open Pit Mining",slug:"open-pit-mining",totalDownloads:1625,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Open pit mining method is one of the surface mining methods that has a traditional cone-shaped excavation and is usually employed to exploit a near-surface, nonselective and low-grade zones deposits. It often results in high productivity and requires large capital investments, low operating costs, and good safety conditions. The main topics that will be discussed in this chapter will include an introduction into the general features of open pit mining, ore body characteristics and configurations, stripping ratios and stripping overburden methods, mine elements and parameters, open pit operation cycle, pit slope angle, stability of mine slopes, types of highwall failures, mine closure and reclamation, and different variants of surface mining methods including opencast mining, mountainous mining, and artisan mining.",book:{id:"8620",slug:"mining-techniques-past-present-and-future",title:"Mining Techniques",fullTitle:"Mining Techniques - Past, Present and Future"},signatures:"Awwad H. Altiti, Rami O. Alrawashdeh and Hani M. Alnawafleh",authors:[{id:"313182",title:"Prof.",name:"Rami",middleName:null,surname:"Alrawashdeh",slug:"rami-alrawashdeh",fullName:"Rami Alrawashdeh"},{id:"313522",title:"Dr.",name:"Awwad",middleName:null,surname:"Altiti",slug:"awwad-altiti",fullName:"Awwad Altiti"},{id:"313523",title:"Prof.",name:"Hani",middleName:null,surname:"Alnawafleh",slug:"hani-alnawafleh",fullName:"Hani Alnawafleh"}]},{id:"64027",title:"Stages of a Integrated Geothermal Project",slug:"stages-of-a-integrated-geothermal-project",totalDownloads:4341,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"A geothermal project constitutes two big stages: the exploration and the exploitation. Each one has a single task whose results allow defining the feasibility of a geothermal project, until achieving the construction and operation stage of the power generation plant. The first stage contains the area recognition, its limitation to the target, and elimination of external factors until defining a geothermal zone with characteristics to be commercially exploited. The main studies and analysis that can be applied during the exploration stage are listed, and the major indicator to continue with the project or suspend is the prefeasibility report. The major risks in the exploration stage are due to studies that are carried out on the surface; at this stage, the costs can be considered low. The main results of the exploration are the selection of sites to drill three or four initial wells. Each well provides a direct overview of the reservoir: depth, production thicknesses, thermodynamic parameters, and production characteristics. The drilling of three to four exploratory wells is recommended, as far as there is certainty of the feasibility of the project, and the development of the field begins with drilling of sufficient wells to feed the plant. In this stage, the cost increases, but the risks decrease.",book:{id:"7504",slug:"renewable-geothermal-energy-explorations",title:"Renewable Geothermal Energy Explorations",fullTitle:"Renewable Geothermal Energy Explorations"},signatures:"Alfonso Aragón-Aguilar, Georgina Izquierdo-Montalvo,\nDaniel Octavio Aragón-Gaspar and Denise N. Barreto-Rivera",authors:[{id:"258358",title:"Dr.",name:"Alfonso",middleName:null,surname:"Aragón-Aguilar",slug:"alfonso-aragon-aguilar",fullName:"Alfonso Aragón-Aguilar"}]},{id:"65070",title:"Biochar: A Sustainable Approach for Improving Plant Growth and Soil Properties",slug:"biochar-a-sustainable-approach-for-improving-plant-growth-and-soil-properties",totalDownloads:6893,totalCrossrefCites:55,totalDimensionsCites:92,abstract:"Soil is the most important source and an abode for many nutrients and microflora. Due to rapid depletion of agricultural areas and soil quality by means of ever-increasing population and an excessive addition of chemical fertilizers, a rehabilitated attention is a need of the hour to maintain sustainable approaches in agricultural crop production. Biochar is the solid, carbon-rich material obtained by pyrolysis using different biomasses. It has been widely documented in previous studies that, the crop growth and yield can be increased by using biochar. This chapter exclusively summarizes the properties of biochar, its interaction with soil microflora, and its role in plant growth promotion when added to the soil.",book:{id:"7305",slug:"biochar-an-imperative-amendment-for-soil-and-the-environment",title:"Biochar",fullTitle:"Biochar - An Imperative Amendment for Soil and the Environment"},signatures:"Jyoti Rawat, Jyoti Saxena and Pankaj Sanwal",authors:null},{id:"39170",title:"Study of Impacts of Global Warming on Climate Change: Rise in Sea Level and Disaster Frequency",slug:"study-of-impacts-of-global-warming-on-climate-change-rise-in-sea-level-and-disaster-frequency",totalDownloads:6659,totalCrossrefCites:14,totalDimensionsCites:32,abstract:null,book:{id:"2206",slug:"global-warming-impacts-and-future-perspective",title:"Global Warming",fullTitle:"Global Warming - Impacts and Future Perspective"},signatures:"Bharat Raj Singh and Onkar Singh",authors:[{id:"26093",title:"Dr.",name:"Bharat Raj",middleName:null,surname:"Singh",slug:"bharat-raj-singh",fullName:"Bharat Raj Singh"},{id:"118426",title:"Prof.",name:"Onkar",middleName:null,surname:"Singh",slug:"onkar-singh",fullName:"Onkar Singh"}]}],onlineFirstChaptersFilter:{topicId:"10",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82311",title:"Remediation of Soil Impacted by Heavy Metal Using Farm Yard Manure, Vermicompost, Biochar and Poultry Manure",slug:"remediation-of-soil-impacted-by-heavy-metal-using-farm-yard-manure-vermicompost-biochar-and-poultry-",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.105536",abstract:"Soil contamination by organic and inorganic compounds is a universal concern nowadays. One such contamination is heavy metal exposure to the soil from different sources. The discharge of effluents from various factories in Punjab like tanning industries, leather industries, and electroplating industries generate a large volume of industrial effluents. These industrial units discharge their effluents directly or through the sewer into a water tributary (Buddha Nallah) and this water is being used for irrigating the crops. The heavy metals enter into the food chain thus contaminating all resources i.e. air, soil, food, and water. Preventive and remedial measures should be taken to reduce the effects of heavy metals from soil and plants. Organic soil amendments like FYM, Vermicomposting, Biochar, and poultry manure have been used to deactivate heavy metals by changing their forms from highly bioavailable forms to the much less bioavailable forms associated with organic matter (OM), metal oxides, or carbonates. These amendments have significant immobilizing effects on heavy metals because of the presence of humic acids which bind with a wide variety of metal(loid)s including Cd, Cr, Cu, and Pb.",book:{id:"10952",title:"Soil Science - Emerging Technologies, Global Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10952.jpg"},signatures:"Neeraj Rani and Mohkam-Singh"},{id:"82451",title:"An Emerging Global Understanding of Arsenic in Rice (Oryza sativa) and Agronomic Practices Supportive of Reducing Arsenic Accumulation",slug:"an-emerging-global-understanding-of-arsenic-in-rice-oryza-sativa-and-agronomic-practices-supportive-",totalDownloads:0,totalDimensionsCites:0,doi:"10.5772/intechopen.105500",abstract:"Arsenic uptake in rice (Oryza sativa) is recognized as a global health emergency, requiring the development of agronomic protocols to reduce human exposure to rice having elevated arsenic concentrations. Recent rice-arsenic investigations have centered around numerous agronomic approaches, including: (i) rice breeding and cultivar selection, (ii) altering irrigation water applications to reduce arsenic soil availability, (iii) application of soil amendments which either support arsenic adsorption on iron-plaque or provide antagonistic competition for root uptake, and (iv) phytoremediation. Given that rice cultivars vary in their arsenic accumulation capacity, this manuscript review concentrates on the influences of water management, soil amendments, and phytoremediation approaches on arsenic accumulation. Water management, whether alternating wetting and drying or furrow irrigation, provides the greatest potential to alleviate arsenic uptake in rice. Phytoremediation has great promise in the extraction of soil arsenic; however, the likelihood of multiple years of cultivating hyperaccumulating plants and their proper disposal is a serious limitation. Soil amendments have been soil applied to alter the soil chemistry to sequester arsenic or provide competitive antagonism towards arsenic root uptake; however, existing research efforts must be further field-evaluated and documented as producer-friendly protocols. The usage of soil amendments will require the development of agribusiness supply chains and educated extension personnel before farm-gate acceptance.",book:{id:"10952",title:"Soil Science - Emerging Technologies, Global Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10952.jpg"},signatures:"Michael Aide and Indi Braden"},{id:"82332",title:"Introductory Chapter: Access to Space, Access to the Moon: Two Sides of the Same Coin?",slug:"introductory-chapter-access-to-space-access-to-the-moon-two-sides-of-the-same-coin",totalDownloads:9,totalDimensionsCites:0,doi:"10.5772/intechopen.105175",abstract:null,book:{id:"10955",title:"Lunar Science - Habitat and Humans",coverURL:"https://cdn.intechopen.com/books/images_new/10955.jpg"},signatures:"Yann-Henri Chemin"},{id:"82329",title:"Bifacial Photovoltaic Technology: Recent Advancements, Simulation and Performance Measurement",slug:"bifacial-photovoltaic-technology-recent-advancements-simulation-and-performance-measurement",totalDownloads:10,totalDimensionsCites:0,doi:"10.5772/intechopen.105152",abstract:"In this chapter, we introduce the physic principle and applications of bifacial PV technology. We present different bifacial PV cell and module technologies as well as investigate the advantages of using bifacial PV technology in the field. We describe the measurement and modeling of Albedo, which is one of the important factors for the energy yield of bifacial PV technology. For an accurate assessment of the performance ratio of bifacial PV strings, it is necessary to measure the albedo irradiance using an albedometer or the front- and rear-side plane of array (POA) irradiance. We also discuss the advanced techniques for the characterization of bifacial PV modules. By means of simulation, we give insight into what boundary conditions result in new bifacial technology gains and the influence of the mounting position of irradiance sensors. We executed several simulations by varying the sensor positions on the rear side of the PV modules, different places, different albedo numbers, mounting heights, different geographical locations with various tilts, seasons, and weather types. To validate the simulation results, we performed various experiments in the field under different conditions. The results prove that the bifacial gain is highly dependent on the mounting heights of PV modules, tilt angles, weather conditions, latitude, and location.",book:{id:"9862",title:"Solar Radiation - Measurements, Modeling and Forecasting for Photovoltaic Solar Energy Applications",coverURL:"https://cdn.intechopen.com/books/images_new/9862.jpg"},signatures:"Mohammadreza Aghaei, Marc Korevaar, Pavel Babal and Hesan Ziar"},{id:"79973",title:"Impacts of Drought on Homestead Plant Diversity in Barind Tract of Bangladesh",slug:"impacts-of-drought-on-homestead-plant-diversity-in-barind-tract-of-bangladesh",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.101885",abstract:"Homestead is a great place for household food access, diet, and nutrition. Drought affects homestead plant diversity and reduces production, availability, and diversity that lead toward less supply and consumption. Drought detains moisture and degrades the soil that supports plant growth. Homestead provides regular bread and income in the rural areas with an effective means for both economic and environmental well-being. People are getting a good amount of subsidiary income without any extra care and effort. In managing homestead land and drought, the household needs necessary technical and managerial training. In reducing drought effects to the homestead, action research needs to be carried out on available knowledge, effective practices, water management, and the adoption of local varieties and knowledge to develop effective homestead integration. Government initiatives, community engagement and not harming the environment, and efficient uses of water could be great solutions for the adverse effects of drought on the homestead plant diversity.",book:{id:"11131",title:"Drought - Impacts and Management",coverURL:"https://cdn.intechopen.com/books/images_new/11131.jpg"},signatures:"Md. Shafiqul Islam"},{id:"81757",title:"Petroleum Geochemistry",slug:"petroleum-geochemistry",totalDownloads:18,totalDimensionsCites:0,doi:"10.5772/intechopen.104709",abstract:"Petroleum geochemistry has entered its second period of growth. The first period, largely associated with conventional oil and gas, occurred in the 70s and 80s when the classic works on source rock characterization, biomarkers, depositional systems, and petroleum generation, including kinetics and basin modeling were the focus. The second period began slightly after the turn of the century as a consequence of the “unconventional resource” revolution and the interest in distressed resources developed, the focus turned to non-hydrocarbon contaminants, new interest in hydrocarbon expulsion and retention, identification of tight rock pay zones, and the development of organic porosity. This chapter will discuss source rock characterization and formation, petroleum generation, expulsion, and retention, correlation among hydrocarbon accumulations and to their source rock(s), and organic porosity.",book:{id:"11139",title:"Geochemistry and Mineral Resources",coverURL:"https://cdn.intechopen.com/books/images_new/11139.jpg"},signatures:"Mei Mei and Barry Katz"}],onlineFirstChaptersTotal:150},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:148,paginationItems:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/165328/images/system/165328.jpg",biography:"Vahid Asadpour, MS, Ph.D., is currently with the Department of Research and Evaluation, Kaiser Permanente Southern California. He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:null},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:"Manufacturing and Technology Integrated Campus – SENAI CIMATEC",institution:null},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"357085",title:"Mr.",name:"P. 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