Face recognition methods overview.
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
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The book provides a comprehensive revision of bioactive peptides obtained from both animal and plant food sources. Aspects related to their bioactivity, mechanism of action, and bioavailability are extensively described along the different chapters. Also, the chapters describe the impact of bioactive peptides on the physiological absorption, regulation and disease prevention. The book also covers the recent technological advances for the production of food peptides. Bioactive Food Peptides in Health and Disease provides updated and interesting information, being a good reference book for nutritional and food scientists, biochemists, industry producers, and consumers.',isbn:null,printIsbn:"978-953-51-0964-8",pdfIsbn:"978-953-51-5351-1",doi:"10.5772/3318",price:119,priceEur:129,priceUsd:155,slug:"bioactive-food-peptides-in-health-and-disease",numberOfPages:278,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"76703fb65cb9e3a20374f3fd1ebc63a8",bookSignature:"Blanca Hernandez-Ledesma and Chia-Chien Hsieh",publishedDate:"January 30th 2013",coverURL:"https://cdn.intechopen.com/books/images_new/2994.jpg",numberOfDownloads:41213,numberOfWosCitations:196,numberOfCrossrefCitations:49,numberOfCrossrefCitationsByBook:11,numberOfDimensionsCitations:207,numberOfDimensionsCitationsByBook:14,hasAltmetrics:1,numberOfTotalCitations:452,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"January 6th 2012",dateEndSecondStepPublish:"March 9th 2012",dateEndThirdStepPublish:"May 31st 2012",dateEndFourthStepPublish:"July 31st 2012",dateEndFifthStepPublish:"December 11th 2012",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"36572",title:"Dr.",name:"Blanca",middleName:null,surname:"Hernández-Ledesma",slug:"blanca-hernandez-ledesma",fullName:"Blanca Hernández-Ledesma",profilePictureURL:"https://mts.intechopen.com/storage/users/36572/images/5506_n.jpg",biography:"Dr. Blanca Hernandez-Ledesma is currently working as a Postdoctoral researcher under the Ramón & Cajal Programme at the Institute of Food Science Research (CSIC-UAM) in Spain. She was working (1998 to 2002) at the Institute of Industrial Fermentations (CSIC), earning her Ph.D. in Pharmacy by the Complutense University of Madrid, Spain in 2002. She continue working as postdoctoral fellow at the CSIC until 2007 when she moved to USA for a postdoctoral work at the University of California, Berkeley. In 2010, she went back to Spain to work as postdoctoral researcher under different contracts. 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On the one hand, recognising face is natural process, because people usually do it effortlessly without much conscious. On the other hand, application of this process in area of computer vision remains a difficult problem. Being part of a biometric technology, automated face recognition has a plenty of desirable properties. They are based on the important advantage—non‐invasiveness. The various biometric methods can be distinguished into physiological (fingerprint, DNA, face) and behavioural (keystroke, voice print) categories. The physiological approaches are more stable and non‐alterable, except by severe injury. Behavioural patterns are more sensitive to human overall condition, such as stress, illness or fatigue.
\nThe brief analysis of the face detection techniques using effective statistical learning methods seems to be crucial as practical and robust solutions.
\nFigure 1 points out the basic elements of the typical face recognition system.
\nCrucial elements of the typical face recognition system.
Face detection performance is a key issue, so techniques for dealing with non‐frontal face detection are discussed. Subspace modelling and learning‐based dimension reduction methods are fundamental to many current face recognition techniques. Discovering such subspaces so as to extract effective features and construct robust classifiers stands another challenge in this area. Face recognition has merits of both high accuracy and low intrusive, so it has drawn the attention of the researches in various fields from psychology, image processing to computer vision.
\nThe first stage is face detection in the acquired image that is regardless of scale and location. It often uses an advanced filtering procedure to distinguish locations that represent faces and filters them with accurate classifiers. It is notable that all translations, scaling and rotational variations have to be dealt in the face detection phase. For example, regarding to [1,2], facial expressions and hairstyle changes or smiling and frowning face still stands important variations during pattern recognition stage.
\nIn the next step, anthropometric data set‐based system predicts the approximate location of the principal features such as eyes, nose and mouth. Of course, whole procedure is repeated to predict the subfeatures, relative to principal features, and verified with collocation statistic to reject any mislocated features.
\nDedicated anchor points are generated as the result of geometric combinations in the face image and then it starts the actual process of recognition. It is carried out by finding local representation of the facial appearance at each of the anchor points. The representation scheme depends on approach. In order to deal with such complication and find out the true invariant for recognition, researchers have developed various recognition algorithms.
\nThere are several boundaries for current face recognition technology (FERET). In [3,4] was provided early benchmark of face recognition technologies. While under ideal conditions, performance is excellent, under conditions of changing illumination, expression, resolution, distance or aging, performance decreases significantly. It is the fact that face recognition systems are still not very robust regarding to deviations from ideal face image. Another problem is an effective way of storing and access granting to facial code (or facial template) stored as a set of features and extracted from image or video.
\nConsidering roughly presented elements above of the complex process of face recognition, a number of limitations and imperfections can be seen. They require clarification or replacing by new algorithms, methods or even technologies.
\nIn this chapter, we have discussed face recognition processing, including major components such as face detection, tracking, alignment and feature extraction, and it points out the technical challenges of building a face recognition system. We focus on the importance of the most successful solutions available so far.
\nThe final part of the chapter describes chosen face recognition methods and applications and their potential use in areas not related to face recognition.
\nThe need for this study is justified by an invitation to participate in the further development of a very interesting technology, which is face recognition.
\nDespite the fact, there is continual performance improvement regarding several face recognition technology areas, and it is worth to note that current applications also impose new requirements for its further development.
\nThere has been a rapid development of the reliable face recognition algorithms in the last decade. The traditional face recognition algorithms can be categorised into two categories: holistic features and local feature approaches. The holistic group can be additionally divided into linear and nonlinear projection methods.
\nMany applications have shown good results of the linear projection appearance‐based methods such as principal component analysis (PCA) [5], independent component analysis (ICA) [6], linear discriminate analysis (LDA) [7,8], 2DPCA [9] and linear regression classifier (LRC) [10].
\nHowever, due to large variations in illumination conditions, facial expression and other factors, these methods may fail to adequately represent the faces. The main reason is that the face patterns lie on a complex nonlinear and non‐convex manifold in the high‐dimensional space.
\nIn order to deal with such cases, nonlinear extensions have been proposed like kernel PCA (KPCA), kernel LDA (KLDA) [11] or locally linear embedding (LLE) [12]. The most nonlinear methods using the kernel techniques, where the general idea consists of mapping the input face images into a higher‐dimensional space in which the manifold of the faces is linear and simplified. So the traditional linear methods can be applied.
\nAlthough PCA, LDA and LRC are considered as linear subspace learning algorithms, it is notable that PCA and LDA methods focus on the global structure of the Euclidean space, whereas LRC approach focuses on local structure of the manifold.
\nThese methods project face onto a linear subspace spanned by the eigenface images. The distance from face space is the orthogonal distance to the plane, whereas the distance in face space is the distance along the plane from the mean image. These both distances can be turned into Mahalanobis distances and given probabilistic interpretations [13].
\nFollowing these, there have been developed: KPCA [14], kernel ICA [15] and generalised linear discriminant analysis [16].
\nDespite strong theoretical foundation of kernel‐based methods, the practical application of these methods in face recognition problems, however, does not produce a significant improvement compared with linear methods.
\nAnother family of nonlinear projection methods has been introduced. They inherited the simplicity from the linear methods and the ability to deal with complex data from the nonlinear ones. Among these methods, it is worth to underline: LLE [17] and locality preserving projection (LPP) [18]. They produce a projection scheme for training data only, but their capability to project new data items is questionable.
\nIn the second category, local appearance features have certain advantages over holistic features. These methods are more stable to local changes such as expression, occlusion and misalignment. The common representative method names local binary patterns (LBPs) [19,20]. The neighbouring changes around the central pixel in a simple but effective way are described by LBP. It is invariant monotonic intensity transformation and supports small illumination variations. Many LBP variants are proposed to improve the original LBP such as histogram of Gabor phase patterns [21] and local Gabor binary pattern histogram sequence [22,23]. Generally, the LBP is utilised to model the neighbouring relationship jointly in spatial, frequency and orientation domains [22].
\nIt allows to explore efficiently discriminant and robust information in the pattern. Further development of the mentioned subspace approaches represents discriminant common vectors (DCVs) approach [24].
\nThe DCV method collects the similarities among the elements in the same class and drops their dissimilarities. Thus, each class can be represented by a common vector computed from the within scatter matrix.
\nIn case of testing an unknown face, the corresponding feature vector is computed and associated to the class with the nearest common vector. Sometimes, kernel discriminative common vectors [25] or improved discriminative common vectors and support vector machine (SVM) [26] are introduced for the face recognition task.
\nSimilarly to the LLE method, neighbourhood preserving projection (NPP) and orthogonal NPP (ONPP) are introduced in [27,28]. These approaches preserve the local structure between samples. To reflect the intrinsic geometry of the local neighbourhoods, they use data‐driven weights by solving a least‐squares problem. ONPP forces the mapping to be orthogonal and then solves an ordinary eigenvalue problem. NPP requires solving a generalised eigenvalue problem, regarding to imposing a condition of orthogonality on the projected data.
\nBlock diagram of the traditional face recognition approaches is presented in Figure 2.
\nTraditional face recognition algorithms.
However, it is still unclear how to select the neighbourhood size and how to assign optimal values for other hyper‐parameters; for them, sparsity preserving projections [29,30] and LPPs [31] are also applied for face recognition.
\nIn [32], a multi‐linear extension of the LDA method called discriminant analysis with tensor representation is proposed. It is different from preserving projection methods and implements discriminant analysis directly on the natural tensorial data to preserve the neighbourhood structure of tensor feature space. Another method of supervised and unsupervised multi‐linear NPP (MNPP) for face recognition is presented in [33]. A survey of multi‐linear methods can be found in [11]. They operate directly on tensorial data rather than vectors or matrices and solve problems of tensorial representation for multidimensional feature extraction and recognition. Multiple interrelated subspaces are obtained in the MNPP method by unfolding the tensor over different tensorial directions. The order of the tensor space determines the number of subspaces derived by MNPP [34,35].
\nIn [11,36,37], artificial neural networks are used to solve nonlinear problem. To recognise human faces, a non‐convergent chaotic neural network is suggested in [38].
\nA radial basis function neural network integrated with a non‐negative matrix factorisation to recognise faces is presented in [39]. Moreover, for face and speech verifications, [40] utilise a momentum back propagation neural network. Non‐negative sparse coding method to learning facial features using different distance metrics and normalised cross‐correlation for face recognition is applied in [41].
\nA posterior union decision‐based artificial neural network approach is proposed in [33,34]. It has elements of both neural networks and statistical approaches and replenishes methods for recognising face images with partial distortion and occlusion.
\nUnfortunately, this approach, like other statistical‐based methods, is inaccurate to model classes given only a single or a small number of training samples [42,43].
\nGabor wavelets have been widely used for face representation by face recognition researchers [44,45,46], and Gabor features are recognised as better representation for face recognition in terms of (rank‐1) recognition rate [47]. Moreover, it is demonstrated to be discriminative and robust to illumination and expression variations [48]. When only one sample image per enrolled subject is available, [49] propose adaptively weighted sub‐Gabor array for face representation and recognition.
\nMoreover, two kinds of strategies to capture Gabor texture information: Gabor magnitude‐based texture representation (GMTR) and Gabor phase‐based texture representation (GPTR), are proposed in [50].
\nGamma density to model the Gabor magnitude distribution characterises GMTR approach. The GPTR is characterised by the generalised Gaussian density for modelling the Gabor phase distribution. It allows the estimated model parameters to be served as texture representation of the face.
\nThe Gabor wavelet applied at fixed positions, in correspondence of the nodes of a square‐meshed grid superimposed to the face image, is presented in [51]. Each subpattern of the partitioned face image is defined as the extracted Gabor features that belong to the same row of the square‐meshed grid which are then projected to lower dimension space by Karhunen–Loeve transform. The obtained features of each subpattern, which are weighted using genetic algorithm (GA), are used to train a Parzen Window Classifier. Finally, matching process is done by combining the classifiers using a weighted sum rule.
\nThe learning approach based on Gabor features and kernel supervised Laplacian faces for face recognition under the classifier fusion framework is introduced in [52]. The Gabor features obtained from each channel as a new sample of the same class are used to adopt the classifier fusion strategy. Such approach is useful for improving the performance of the recognition results.
\nHistogram of Gabor phase feature is proposed in [53]. In [54,55,56,57,58], the patch‐based histograms of local patterns are concatenated together to form the representation of the face image via learned local Gabor patterns. The feature representation problem by providing a learning method instead of simple concatenation or histogram feature is presented in [59]. In [60], the Gabor features were adopted for the sparse representation (SR)‐based classification and a Gabor occlusion dictionary was learned under the well‐known SR framework.
\nThe main drawback of Gabor‐based methods is that the dimensionality of the Gabor feature space is significantly high since the face images are convolved with a bank of Gabor filters.
\nTo overcome this problem, Adaboost algorithm [61] and entropy and genetic algorithms (GA) [62] are used to select the most discriminative Gabor features.
\nHowever, selecting the most useful method from so many Gabor features is very time‐consuming [61]. Furthermore, extracting the Gabor features is computationally intensive, so the features are currently useless for real‐time applications [63]. A simplified version of Gabor wavelets is introduced in [64]. Unfortunately, the simplified Gabor features are more sensitive to lighting variations in reference to the original Gabor features.
\nLocal feature‐based face image description provides a global description. So local features of the image are evaluated in the neighbouring pixels and then aggregated to form the final global description [65,66]. This is unlike global methods in which the entire image is utilised to produce each feature, where the first steps start with the description of the face realised at a pixel level by making use of the local neighbourhood of each pixel. Then, the image is divided into a number of subregions, and from each subregion, a local description is formed as a histogram of the pixel level descriptions calculated in the previous step. Next, the information of the regions is combined into the final descriptor by concatenating the partial histograms [67,68].
\nTo determine image descriptors that are able to improve classification performance of multi‐option recognition as well as pair matching of face images seems to be a complex problem [65,69,70].
\nLearning the most discriminant local features that can minimise the difference of the features between images of a same individual and maximise that between images from other people depending on the nature of these descriptors, which compute an image representation from local patch statistics stands the main idea of the approach.
\nThe face verification accuracy ranked on the LFW benchmark after face verification using multiple local descriptors designed to capture statistics of local patch similarities is proposed in [34]. Enhancing the face recognition performance by introducing the discriminative learning into three steps of LBP‐like feature extraction is presented in [71].
\nThe discriminant image filters, the optimal soft sampling matrix and the dominant patterns are all learned from images. The general advantage of these methods is compact, highly discriminative and easy to extract learning‐based descriptor. These methods are discriminative and robust to illumination and expression changes.
\nAs 3D capturing process is becoming cheaper and faster [72], it is commonly thought that the use of 3D sensing has the potential for greater recognition accuracy than 2D. The advantage behind using 3D data is that depth information does not depend on pose and illumination, and therefore, the representation of the object does not change with these parameters, making the whole system more robust. 3D‐based techniques can achieve better robustness to pose variation problem than 2D‐based ones. A comprehensive survey of the 3D face recognition approaches is presented in [73].
\nA method for face recognition across variations in pose, which combines deformable 3D models with a computer graphics simulation of projection and illumination, can be found in [74]. In this method, faces are represented by model parameters for 3D shape and texture. Their 3D morphable models are combined with spherical harmonics illumination representation [75] to recognise faces under arbitrary unknown lighting.
\nUsing facial symmetry to handle pose variation in 3D face recognition is presented in [76], where an automatic landmark detector is used. It helps to estimate pose and detects occluded areas for each facial scan. Subsequently, an annotated face model is registered and fitted to the scan. During fitting, facial symmetry is used to overcome the challenges of missing data [77].
\nThere is a generic 3D elastic model for pose invariant face recognition proposed in [29]. It is constructed for each subject in the database using only a single 2D image by applying the 3D generic elastic model (3DGEM) approach. Each 3D model is subsequently rendered at different poses within a limited search space about the estimated pose, and the resulting images are matched against the test query. Finally, the distances between the synthesised images and test query are computed by using a simple normalised correlation matcher to show the effectiveness of the pose synthesis method to real‐world data.
\nIn [78], a geometric framework for analysing 3D faces, with the specific goals of comparing, matching and averaging their shapes, is proposed to represent facial surfaces by radial curves emanating from the nose tips.
\n3D face recognition approach based on local geometrical signatures called facial angular radial signature (ARS) that can approximate the semi‐rigid region of the 3D face is proposed in [79]. The authors employed KPCA to map the raw ARS facial features to mid‐level features to improve the discriminating power. Finally, the resulting mid‐level features are combined into one single feature vector and fed into the SVM to perform face recognition [80, 81, 82, 83, 84, 85, 86].
\nThe drawback of using 3D data in face recognition is that these face recognition approaches need all the elements of the system to be well calibrated and synchronised to acquire accurate 3D data (texture and depth maps). The existing 3D face recognition approaches rely on a surface registration or on complex feature (surface descriptor) extraction and matching techniques. They are, therefore, computationally expensive and not suitable for practical applications. Moreover, they require the cooperation of the subject making them not useful for uncontrolled or semi‐controlled scenarios where the only input of the algorithms will be a 2D intensity image acquired from a single camera.
\nThe analysis of video streams of face images has received increasing attention in biometrics [87]. An immediate advantage in using video information is the possibility of employing redundancy present in the video sequence to improve still image systems. Although significant amount of research has been done in matching still face images, the use of videos for face recognition is relatively less explored [88]. The first stage of video‐based face recognition (VFR) is to perform re‐identification, where a collection of videos is cross‐matched to locate all occurrences of the person of interest [89].
\nGenerally, VFR approaches can be classified into two categories based on how they leverage the multitude of information available in a video sequence: (i) sequence based and (ii) set based, where at a high level, what most distinguishes these two approaches is whether or not they utilise temporal information [90, 91].
\nThe formulation of a probabilistic appearance‐based face recognition approach is extended in [92]. Originally, it was defined to do recognition from a single still image as previously explained, to work with multiple images and video sequences. In [93], there is the constrained subspace spanned from face images of a clip into a convex hull and then calculate the nearest distance of two convex hulls as the between‐set similarity. Thus, each test and training example is a set of images of a subject\'s face, not just a single image, so recognition decisions need to be based on comparisons of image sets.
\nIn [94], VFR task is converted into the problem of measuring the similarity of two image sets, where the examples from a video clip construct one image set. The authors consider face images from each clip as an ensemble and formulate VFR into the joint sparse representation (JSR) problem. In JSR, to adaptively learn the sparse representation of a probe clip, they simultaneously consider the class‐level and atom‐level sparsity, where the former structures the enrolled clips using the structured sparse regulariser and the latter seeks for a few related examples using the sparse regulariser.
\nIn order to identify the most important advantages and imperfections, discussed above methods are summarised in Table 1.
\nNo. | \nMethod | \nAdvantages | \nDisadvantages |
---|---|---|---|
1. | \nClassical face recognition algorithms | \nFocuses on local structure of the manifold. These methods project face onto linear subspace spanned by the eigenface images. The distance from face space is orthogonal to the plane of mean image, so may be easily turned to Mahalanobis distances with probabilistic interpretation | \nThese methods may fail to adequately represent faces when large variations in illumination facial expressions and other factors occur. Regarding to [34], applying kernel‐based nonlinear methods do not produce a significant improvement comparing to linear methods. LLE, LLP and LBP brought simple and effective way to describe neighbouring changes in face description. Subspace approaches were applied in DCV‐ and SVM‐based methods. Preserving the local structure between samples is the domain of NPP and ONPP methods. The problem is that it is still unclear how to select the neighbourhood size or assign optimal values for them | \n
2. | \nArtificial neural networks | \nRadial basis function artificial neural network is naturally integrated with non‐negative matrix factorisation. Also other approaches for process simplification regarding to ANNs native linearisation feature and computation speed up. Ideal solution, especially for recognising face images with partial distortion and occlusion | \nThe main disadvantage of this approach is requirement of greater number of training samples (instead one or limited number). It is inaccurate in the same way like other statistically based methods | \n
3. | \nGabor wavelets | \nThe Gabor wavelets exhibit desirable characteristics of capturing salient visual properties like spatial localisation orientation selectivity and spatial frequency. Different biometrics applications favour this approach | \nThe drawback of the Gabor‐based methods is significantly high dimensionality of the Gabor feature space since face image is convolved with a bank of Gabor filters. Approach is computationally intensive and impractical for real‐time applications. Additionally, simplified Gabor features are sensitive to lightning variations | \n
4. | \nFace descriptor‐based methods | \nThe main idea behind developing image descriptors is to learn the most discriminant local features that minimise difference between images of the same individual and maximise that between images from the other people. These methods are discriminative and robust to illumination and expression changes. They offer compact, easy to extract and highly discriminative descriptor | \nApproach is computationally intensive during descriptor extraction stage, but encouraging simplicity and performance in reference to online applications | \n
5. | \n3D‐based face recognition | \nExtend traditional 2D capturing process and has greater potential for accuracy. The depth information does not depend on the pose and illumination making solution more robust | \nRequire all the elements of the 3D face recognition system to be well calibrated and synchronised to existing 3D data. Computationally expensive and not suitable for practical applications | \n
6. | \nVideo‐based recognition | \nThe main advantage of the approach is possibility of employing redundancy present in video to improve still image systems | \nRelatively poorly investigated. Multiply problems with measuring similarity of two (or more) images | \n
Face recognition methods overview.
Methods indicated in the Table 1 illustrate the evolution of face recognition technology. The huge potential of face descriptor‐based methods ought to be emphasised, regarding to the fact the local descriptor idea has been recently recognised as the most crucial design framework for face identification and verification tasks [34].
\nMany published works mention numerous applications in which face recognition technology is already utilised including entry to secured high‐risk spaces such as border crossings as well as access to restricted resources [95, 96, 97]. On the other hand, there are other application areas in which face recognition has not yet been used. The potential application areas of face recognition technology can be outlined as follows [34]:\n
Automated surveillance, where the objective is to recognise and track people [98].
Monitoring closed circuit television (CCTV), the facial recognition capability can be embedded into existing CCTV networks, to look for lost children or other missing persons or tracking known or suspected criminals.
Image database investigations, searching image databases of licensed drivers, benefit recipients and finding people in large news photograph and video collections [99, 100], as well as searching in the Facebook social networking web site [101].
Multimedia environments with adaptive human computer interfaces (part of ubiquitous or context aware systems, behaviour monitoring at childcare or centres for old people, recognising customers and assessing their needs) [102].
Airplane‐boarding gate, the face recognition may be used in places of random checks merely to screen passengers for further investigation. Similarly, in casinos, where strategic design of betting floors that incorporates cameras at face height with good lighting could be used not only to scan faces for identification purposes, but possibly to afford the capture of images to build a comprehensive gallery for future watch‐list, identification and authentication tasks [103].
Sketch‐based face reconstruction, where law enforcement agencies in the world rely on practical methods to help crime witnesses reconstruct likenesses of faces [104]. These methods range from sketch artistry to proprietary computerised composite systems [105, 106, 107].
Forensic applications, where a forensic artist is often used to work with the eyewitness in order to draw a sketch that depicts the facial appearance of the culprit according to his/her verbal description. This forensic sketch is used later for matching large facial image databases to identify the criminals [108, 109]. Yet, there is no existing face recognition system that can be used for identification or verification in crime investigation such as comparison of images taken by CCTV with available database of mugshots. Thus, utilising face recognition technology in the forensic applications is a must as discussed in [110, 111].
Face spoofing and anti‐spoofing, where a photograph or video of an authorised person\'s face could be used to gain access to facilities or services. Hence, the spoofing attack consists in the use of forged biometric traits to gain illegitimate access to secured resources protected by a biometric authentication system [112, 113]. It is a direct attack to the sensory input of a biometric system, and the attacker does not need previous knowledge about the recognition algorithm. Research on face spoof detection has recently attracted an increasing attention [114], introducing few number of face spoof detection techniques [115, 116, 117]. Thus, developing a mature anti‐spoofing algorithm is still in its infancy and further research is needed for face spoofing applications [118, 119].
There have been envisaged many applications for face recognition, but most of commercial ones exploit only superficially the great potential of this technology. Most of the applications are notable limited in their ability to handle pose, lighting changes or aging.
\nIn reference to
The most of physical access control systems uses face recognition combination with other biometrics, for example speaker identification and lip motion [120].
\nOne of the most interest in face recognition in application domain is associated with surveillance. Regarding to the generous type of information it contains, video is the medium of choice for surveillance. For applications that require identification, face recognition is the best biometric for video data. The biggest advantage of this approach is passive participation of subject (human). The whole process of recognition and identification can be carried out without the person\'s knowledge.
\nAlthough the development of face recognition surveillance systems has already begun, the technology seems to not accurate enough. It also brings additional problems concerning highly extensive perception in the data gathering and computing side of such complex solutions.
\nAnother future domain, where face recognition is expected to become important, is area of pervasive or ubiquitous computing. Computing devices equipped with sensors become more widespread in reference to together networking. Such approach will allow envisage a future where the most of everyday objects are going to have some computational power, allowing to precisely adapt their behaviour to various factors including time, user, user control or host.
\nThis vision assumes easy information exchange, also including images between devices of different types.
\nCurrently, the most of devices have simple user interface, controlled only by active commands on the part of the user. Some of the devices are able to sense environment and acquire information about the physical word and the people within their region of interest. One of the crucial part of smart devices of human awareness is knowing the identity of the users close to a device, even currently implemented in several smartphones with different results. It is important when contributed with other biometrics regarding to passive nature of face recognition.
\nFace recognition is still a challenging problem in the field of computer vision. It has received a great deal of attention over the past years because of its several applications in various domains. Although there is strong research effort in this area, face recognition systems are far from ideal to perform adequately in all situations form real world. Paper presented a brief survey of issues methods and applications in area of face recognition. There is much work to be done in order to realise methods that reflect how humans recognise faces and optimally make use of the temporal evolution of the appearance of the face for recognition.
\nThe respiratory system is anatomically divided into the following two parts: upper respiratory tract (organs outside the chest: nose, pharynx, and larynx) and lower respiratory tract (organs inside the chest: trachea, bronchi, bronchioles, alveolar ducts, and alveoli). This system that performs three basic functions, i.e., air transmission, air filtration, and gas exchange (respiration), is functionally divided into two zones. These are the conductive zones (from the nose to the bronchioles) that act as a pathway for the delivery of inhaled gases, and the respiratory zone (from the alveolar canal to the alveoli) where gas exchange occurs. The branching pattern of the conducting passages is known as the tracheobronchial tree as it resembles the branching of a tree [1].
The lungs, the main organ of the respiratory system, are divided into two sections depending on the functions of their structural parts. These are the tubes that conduct air (bronchi and bronchioles) and respiratory tissue (alveolar ducts, alveolar sacs, and alveoli). Ventilated by a secondary (lobar) bronchus, each lobe of the lung is divided into smaller pyramidal-shaped segments known as the bronchopulmonary segments and is ventilated by a tertiary (segmental) bronchus [2].
The bronchi of the lower respiratory tract are vital in terms of respiratory aspects because they are responsible for the transmission and filtration of air as well as for key immunological functions.
The bronchial wall is microscopically composed of the following five sections: mucosa, muscle, submucosa, cartilage, and peribronchial connective tissue (adventitia) (Figure 1) [3].
Light microscopic view of the bronchial wall, rat lung (H-E). Black star: bronchial lumen, black arrow: respiratory epithelium layer, white arrow: lamina propria layer, red arrow: smooth muscle layer, yellow arrow: submucosa layer, white star: distinctive lung tissue (LT) showing the many empty spaces of pulmonary alveoli.
The epithelial and lamina propria layers constitute the bronchial mucosa layer, which has the characteristics of the respiratory mucosa. The initial part of the bronchi exhibits a similar structure to that of the trachea, which is a pathway responsible for the transmission of air taken from the external environment into the lungs. The structure of the bronchial wall changes histologically at the point where it enters the lungs and transforms into intrapulmonary bronchi. In the beginning, the bronchial mucosa comprises a layer of respiratory epithelium with the same cellular composition as the trachea. The height of the cells of this ciliated layer, also known as the pseudostratified columnar epithelium, decreases in proportion to the diameter of the bronchus. The prominent cell types in the epithelium are ciliated cells, goblet cells, basal cells, brush cells, and neuroendocrine cells. The epithelial layer is separated from other mucosal layers by a basement membrane [4].
The basement membrane is prominent in the primary bronchi; however, it rapidly decreases in thickness and disappears as a separate structure in the secondary bronchi. The lamina propria layer is similar to the trachea, but it decreases in proportion to the diameter of the bronchi. The lamina propria layer, which appears as a typical loose connective tissue with abundant elastic and collagen threads, is rich in cellular structures. In addition to the cell types such as plasma cells, mast cells, eosinophils, and fibroblasts, it comprises a large number of lymphocyte cells. The lymphocytes in this layer gather in the form of infiltrates at some places and lymph follicles at some [3].
The muscularis layer, which comprises multiple rows of circular smooth muscle cells, is a continuous layer of smooth muscles in the large bronchi. However, in the small bronchi, it is weakly and loosely organized because it may appear discontinuous due to its spiral route. This layer is responsible for determining the appropriate airway diameter for airflow regulation. In the large bronchi, the loose connective tissue submucosa layer is evident, whereas in the small bronchi, it is only observed as a narrow patch. In addition to the venous plexus and lymph follicles, bronchial glands known as GI. bronchioles are quite common in this layer. These glands, similar to salivary gland tissue, comprise a mixture of serous and mucinous cells and decrease in quantity as the diameter of the bronchi decreases (Figure 2) [3, 5].
A higher power light microscopic view of the bronchial wall, rat lung (H-E). Black arrow: respiratory epithelium layer, white arrow: lamina propria layer, red arrow: smooth muscle layer.
The cartilage layer is observed as a whole in the trachea, whereas it is irregularly present at the beginning of the bronchi in the form of hyaline cartilage. As the diameter of the bronchus decreases, the fragmented cartilage layer becomes smaller and appears as elastic cartilage. On the other hand, the peribronchial connective tissue (adventitia) layer is dense that limits the bronchi from the alveoli and is rich in nerve and elastic fibers in addition to large blood and lymph vessels [3].
The lower respiratory tract is constantly exposed to a wide variety of airborne foreign bodies because it is in direct communication with the external environment for gas exchange [6]. Both the trachea and bronchi function as filters against this exposure due to some of their structural features. The bronchial epithelium has a similar histological structure to the trachea and can capture foreign bodies through the smear of the mucus film secreted by the goblet cells to the kinocilium at the apical ends of the prismatic cells present in its structure. These bodies are captured and removed from the lungs by the movement of the kinocilium toward the larynx [7]. Mechanical filtering of inhaled air is thus ensured due to this primary defense mechanism.
The lower respiratory tract is constantly exposed to allergens, antigens, bacteria, and viruses during gas exchange. This is a very sensitive area for various types of pathogen invasions, such as influenza virus, measles virus, and
The tracheobronchial tree, which is considered as an immunological organ, [13] is important for the defense mechanism of microorganisms reaching the lungs through inhaled air as well as for hypersensitive reactions that occur through respiration. The lymphoid tissue of the tracheobronchial system contains specialized diffuse, clustered, and solitary lymphatic nodules known as bronchus-associated lymphoid tissue [14, 15]. This secondary lymphoid tissue is a representative of the mucosal immune system in the bronchial wall, which is common in different parts of the body. It forms the immunoglobulins as a result of the immune defense reaction, thus forming a special protective mechanism of the lower respiratory system.
The immune system can recognize a wide range of unknown antigens and elicit an appropriate respond due to the lymphocytes that have a wide variety of antigen receptors [16]. This system has evolved into a system of secondary lymphoid organs such as the spleen, lymph nodes, Peyer’s patches, and other MALT, in line with the defense targets [17]. Highly organized secondary lymphoid organs contain architectural domains that facilitate sequential cellular interactions between antigen-presenting cells and lymphocytes and efficiently promote the activation, selection, and differentiation of B and T cells [16]. Therefore, the immunological response becomes more effective.
MALT can function independently of the systemic immune system and therefore encompasses the mucosal immune system, which is a crucial part of immunopathology [18]. It plays an important role in immunological defense by eliciting immune responses against specific antigens encountered along the surfaces of all mucosal tissues [19]. Although MALT is anatomically divided into regions, these regions are functionally interconnected under the name of the common mucosal immune system. In this way, events such as antigen presentation and B-cell activation in a mucosal region can trigger the secretion of immunoglobulin A (IgA) in the mucosal regions of different organs [18, 20]. Due to MALT, which mainly functions to produce and secrete IgA along the mucosal surfaces in antigen-specific, T helper 2-dependent reactions, T helper 1 and cytotoxic T-cell-mediated reactions can occur. This may then result in immunotolerance [20, 21].
The best-known representatives of MALT, which contains approximately half of the lymphocytes of the immune system, [22] are gut-associated lymphoid tissue (GALT), nasal-associated lymphoid tissue (NALT), and BALT. However, structures such as conjunctival-associated lymphoid tissue (CALT), larynx-associated lymphoid tissue, and duct-associated lymphoid tissue (DALT) are other MALT representatives [20, 21].
MALT is divided into the two following functional parts: inducer sites and effector sites. Inducer sites include secondary lymphoid tissues, where the clonal expansion of B cells and IgA class transition occur in response to antigen-specific T-cell activation [19]. GALT, BALT, NALT, and CALT in mice, dogs [23], and baboons [24] and DALT in cynomolgus macaques [25] constitute these inducing sites. These sites are known as secondary immune tissues where antigen sampling occurs, and immune responses are initiated. Although there are many differences between inducing sites in various organs, they all contain the same functional segments as follows: lymphoid follicles, interfollicular zones, subepithelial dome zones, and follicle-associated epithelium or lymphoepithelium containing microfold (M) cells [19].
Effector sites distributed as diffuse lymphoid tissue throughout the lamina propria layer on all mucosal surfaces [26] are known as the transport sites of IgA along the mucosal epithelium. After activation and IgA class transition, T- and B cells migrate from inducing sites to these sites [19]. CD4+ and CD8+ T cells, IgA-, IgG- and IgM-plasma cells, B cells, antigen-presenting dendritic cells, and macrophages [19] constitute the cellular content of these effector regions where secreted IgA (S-IgA) is secreted along the mucosal epithelium [27]. Mast cells and eosinophils can occasionally be seen in the interfollicular area. Thus, all the cell types required to initiate an immune response are present here.
BALT, an important part of MALT, is classically used to refer to intrapulmonary lymphoid tissue in connection with the pulmonary vessels and adventitia of the bronchi [11, 28]. Macklin [29] named this lymphoid tissue in 1955 as ‘sumps’ or ‘pulmonary tonsils’ in which dust and organisms are retained. Subsequently, Bienenstock et al. [28, 30] identified these formations as subepithelial follicular lymphoid aggregates, primarily composed of lymphocytes, organized in the bronchial mucosa in contact with the surface epithelium, and coined the term BALT to describe them.
Although BALT, a secondary lymphoid tissue that plays an important role in the maintenance and regulation of lung mucosal immune homeostasis [8], was initially claimed to resemble Peyer’s patches in the small intestine [11]; it was later revealed that it was quite different from these formations [31]. Compared to GALT where in the founder Peyer’s patches are located, it is accepted that BALT is not regularly present during fetal life due to embryonic preprogramming; however, it occurs with antigenic stimulation during the postnatal period [32, 33]. In other words, it is claimed that there is a relatively special lymphoid tissue in the development of BALT. However, studies have shown that BALT exhibits great differences between species [34, 35].
BALT, which was first identified in the bronchial wall of rabbits by Bienenstock et al. [28], is frequently detected in these animals and has the highest number of regions [28, 34]. In terms of the presence and distribution of BALT, rats and guinea pigs [34] follow rabbits, whereas germ-free pigs [28, 34], cats, dogs, and Syrian hamsters [34, 36] do not have this lymphoid tissue. BALT is frequently present in poultry, particularly hens [37]. In mice and humans, the situation with BALT is a little more contradictory [19]. Some scientists suggest that BALT is present in germ-free mice when antigenic stimulation is absent [12], whereas others report that it is not [38, 39]. Besides the differing viewpoints on the presence of BALT in mice, it is assumed that it is only observed infrequently after the neonatal period.
Further, it is claimed that BALT is not present in structurally healthy humans [31] because the features similar to BALT in mice are also found in humans [8]. BALT, in particular, is detectable if it is induced in adults; however, it is only observed in 40% healthy children and adolescents. Factors inducing the presence and distribution of BALT in these adults include infection, pathogen exposure, chronic pulmonary inflammation or autoimmune disease, etc. [32, 33, 40]. Moreover, it is suggested that the formation, size, and amount of BALT depend on the type and duration of exposure [41]. Therefore, it is concluded that BALT varies in different species as well as indifferent physiological states of the same species [8].
Most of the secondary lymphoid organs found in mice and humans develop embryonically in the absence of microbial stimulation or environmental antigens [42]. Furthermore, the structure and function of several secondary lymphoid organs, particularly those on the mucosal surfaces, are dramatically altered upon exposure to foreign antigens and commensal organisms [43]. Peyer’s patches of MALT demonstrate a striking increase in size and complexity following the colonization of commensals [44, 45]. Similarly, in rodents, NALT is not completely developed until the postnatal period; however, microbial exposure accelerates this process [46]. On the other hand, the appendix tissue of rabbits has the characteristics of the primary and secondary lymphoid tissues in terms of being functionally dependent on microbial colonization [47]. However, some lymphoid tissues, known as tertiary lymphoid tissues, develop only after environmental exposure to microbes, pathogens, or inflammatory stimulations. Interestingly, although the lungs of mice and humans normally lack organized lymphoid tissue, tertiary lymphoid structures are frequently observed in lung tissue [38, 48].
BALT is recognized as an inducible tertiary or ectopic lymphoid tissue, unlike the related secondary lymphoid organs. BALT develops during the postnatal period and at anatomically non-lymphoid sites. In terms of disease states characterized by chronic inflammation, infection, or autoimmunity, BALT formation can be induced, and these areas are then known as iBALT [32, 38]. iBALT is a classic example of tertiary lymphoid tissue because it does not develop on a preprogrammed basis; its creation, size, and number in the lungs depend on the type and duration of antigenic exposure [31, 49]. iBALT regions are best characterized in the lungs of rodents and humans. They are observed in the lungs of mammals and birds as well as in possibly all air-breathing vertebrates [41]. The emerging arguments confirm the role of infectious agents, such as isolated lymphoid follicles in the gut, indicating that iBALT may develop in response to microbial exposure [32]. In contrast, BALT is said to have been discovered in germ-free rats [28] and mice [50] as well.
Unlike the classical BALT structure, iBALT does not always have an overlying lymphoepithelium, is not associated with a continuous airway, and can be located adjacent to small pulmonary arteries in the lung parenchyma [32]. However, as both BALT and iBALT have the same function, both tissue types are called BALT [48].
Microscopically, BALT is defined as a densely packed cluster of lymphocytes with follicular structures enveloped in a network of reticular stromal cells beneath a specialized airway epithelium devoid of cilium. These structures are claimed to be located along the main bronchial airways embedded in the airway wall with extensive lymphocytic infiltration of the epithelial layer forming a classical dome epithelium (Figures 3 and 4) [11].
Light microscopic view of the BALT structure, rat lung (H-E). Red star: BALT formation.
A higher power light microscopic view of the BALT structure, rat lung (H-E). Red star: BALT formation.
Further, it is stated that BALT is present in bronchial tree bifurcations to capture respiratory antigens. In species, BALT develops in response to various stimulations rather than being constitutively present in the lung, whereas iBALT does not always have such a defined structure or precise localization in the lung [51].
As a part of the integrated mucosal system including GALT, NALT, and other secondary lymphoid tissue representatives, BALT is known to contain cell types that are responsible for eliciting an appropriate immune response. BALT is mainly defined as an organized structure comprising T- and B-cell domains, dendritic cells (DCs), stromal cells, and high endothelial venules (HEVs) in the T-cell region [38, 52, 53, 54, 55]. Furthermore, it is stated that most of its cellular component consists of B cells expressing IgMlo IgDhi; however, depending on the nature of the microbe and/or antigen to which the cells respond, IgG-, IgA-, and even IgE-positive plasma cells may also be present [50, 56, 57, 58].
Moreover, in BALT, the most prominent structure is follicular-like lymphocyte accumulation, which is the common microscopic appearance of secondary lymphoid tissues, forming a classical germinal center (active site) [59, 60]. In this structure, surrounded by more mature, small lymphocytes, most of the germinal center comprises antigen-presenting macrophages [58, 61]. Lymphocytes leave the blood and migrate to BALT in the walls of HEVs, which are present at the periphery of the tissue. As there are no afferent lymphatics, these HEVs are thought to be the only entry site where lymphocytes migrate to BALT [59, 60]. In addition, the expression of chemokines in HEVs ensures accurate targeting of lymphocytes to lymphoid tissues [62].
However, in the direction of the bronchial epithelium, a dome-like protrusion similar to Peyer’s patches toward the bronchial lumen is sometimes clearly observed [31]. The B-cell follicle, which is the most noticeable characteristic in classic BALT tissues with dome epithelium, is positioned below the epithelium [11]. CD4+ T cells are abundant in B-cell follicles, especially in reactive follicles with germinal centers [63], and CD8+ T cells are uncommon. Moreover, BALT is covered by a lymphoepithelium, which contains M cells that are similar to the M cells present in the dome epithelium of Peyer’s patches in some species [31]. M cells are thought to transport antigens from the mucosal lumen to DCs that are in close contact with the dome epithelium [48]. Rabbits, the first and important representative of BALT, have fewer ciliated cells, few goblet cells, and many lymphocytes between epithelial and M cells. Although this basic structure appears to be valid for all species, there are some differences in details [31].
Another cell type that makes up the cellular component of BALT is follicular DCs (FDCs). These cells depend on the lymphotoxin signaling pathway to differentiate into conventional lymphoid tissues and BALT [38]. Located at the center of B-cell follicles, these cells present antigen to B cells [64] and provide costimulatory signals that increase B-cell activation and proliferation in germinal centers [65, 66]. FDCs in mice are characterized by their ability to bind to antibodies against CD21/CD35 [38], FDCM1, or FDCM2 [57] and to sequester their immune complexes [67]. In addition, FDCs are responsible for the organization of the follicle and expression of CXCL13, which is responsible for the recruitment of B cells and some T cells in the B-cell area [68]. DCs located at the highest concentration in the T-cell areas of BALT are reportedly capable of preserving the BALT architecture as well as their antigen-presenting ability [48].
BALT is induced to produce IgA+ cells that secrete polymeric IgA, mainly due to its role in immunity. When polymeric IgA is transported into the lumen, it induces the formation of S-IgA, which has considerable immunological importance [8]. Thus, when BALT is identified as part of the integrated mucosal immune system, the term should be restricted to structures tightly associated with an epithelium infiltrated by lymphocytes. In the integrated mucosal immune system, specific antigen uptake and antigen presentation by M cells occur and immune reactions are initiated, including IgA responses [31].
Immunohistological studies in humans show a preferential central localization of B cells mixed with some CD4+ lymphocytes and macrophages. CD4+ lymphocytes are also present in the area around the HEV, at the edge resembling a crown, and in the epithelium. In addition to the few proliferative cells positive for Ki67 observed in the follicles, many cells positive for the human leukocyte antigen-DR isotype, which is associated with various autoimmune conditions, disease susceptibility, and disease resistance, are evenly distributed in the follicle [69]. This basic structural distribution of lymphoid and non-lymphoid cells has also been noted in BALT in pathological conditions such as rheumatoid arthritis [70], hypersensitivity pneumonia [71], or diffuse panbronchiolitis [72]. Therefore, it is reasonable to conclude that BALT plays an important role in many respiratory system-related pathologies.
BALT plays an important role in pulmonary immunity such as regulating microbial homeostasis [73], inducing immune tolerance [74], inhibiting inflammation [75], and supporting immune clearance [76]. Therefore, BALT frequently encounters many pathologies associated with infectious disease agents, allergens, environmental antigens, air-borne particles, autoimmune disease agents, and factors causing malignancy. As these pathological conditions have a broad spectrum, it is not possible to discuss all the roles of BALT; therefore, only a few have been addressed.
The respiratory tract is a typical entry site for viruses. This makes it difficult for the immune system to effectively eliminate viruses and virus-infected cells without causing much damage and inflammation, which jeopardizes the lung’s structural and functional integrity. The balance between eliciting an immune response to effectively eliminate viruses and virus-infected cells and to cause less damage and inflammation is maintained by a complex network of innate and adaptive immune mechanisms as well as immunomodulatory and anti-inflammatory mechanisms. Accordingly, BALT could be one of the mechanisms that facilitates viral clearance by eliciting immune responses and decreasing inflammatory responses [48]. BALT reportedly initiates pulmonary immune responses that are faster and more protective than those initiated at systemic sites. It has been proposed that once generated, BALT could play a key role in combating successive rounds of the same infection as well as assisting in establishing local immunity against unrelated viruses or pathogens [51]. For example, it has been suggested that
Endotoxin, known as lipopolysaccharide (LPS), is a component of the gram-negative bacteria [84, 85] that is commonly present in the environment [86, 87]. The development or exacerbation of asthma [86, 87], bronchitis, and chronic obstructive pulmonary disease [88, 89] is linked to considerable LPS exposure. LPS, a classical T-cell-independent B-cell antigen, and mitogen are thought to bind to TLR4 signaling pathway [84, 85], triggering B-cell activation, proliferation, and differentiation into antibody-secreting cells [90]. TLR4 signaling activates macrophages and DCs, epithelial cells, and even fibroblasts, causing them to produce inflammatory cytokines and chemokines [91, 92]. Experimentally, pulmonary exposure of rats to endotoxin has been found to cause increases in pre-existing BALT and pulmonary plasma cells, ultimately leading to the formation of germinal centers [93]. Sustained dosing of LPS prior to pulmonary inflammation in BALT-deficient mice appeared to result in BALT development in the major airways with an accumulation of B cells, T cells, and macrophages in the lungs, and even in BALT-deficient areas [94]. Thus, environmental exposures to LPS, often with additional antigenic or inflammatory components, cause BALT reactivity and pulmonary physiology alterations [95].
Considering the importance of pulmonary inflammation in asthma, a correlation between BALT development and asthma is likely. However, some believe that the presence of BALT is not always associated with asthma [96], but that the reactivity of BALT in patients with asthma is elevated [97]. Further, there is evidence that specific allergens, such as
Hypersensitivity pneumonia is defined as an inflammatory disease of the alveoli induced by hypersensitivity to inhaled organic antigens [99]. In contrast to asthma, which affects the airways, this condition affects the alveoli [48]. An occupational exposure often is the cause of hypersensitivity pneumonia; it can occur particularly when farmers are exposed to mold and fungi in barns [100]. Considering that hypersensitivity pneumonia results from chronic pulmonary exposure to the antigen, the emergence of well-developed BALT areas with vast germinal centers and FDC networks is not surprising for researchers [61].
The lungs are exposed to a wide range of particles, many of which are naturally inflammatory because they cannot be metabolized and persist in phagocytes or because their components bind to specific receptors that trigger an inflammatory response. Silicosis, for example, is a chronic diffuse parenchymal lung disease caused by prolonged exposure to inhaled crystalline silica particles. Pulmonary silica exposure reportedly results in nodules of mononuclear cell infiltration at the location of silica deposition, leading to pulmonary fibrosis [101]. It has been proposed that pulmonary exposure of rats to silica causes silica-loaded alveolar macrophages to migrate across the epithelium and accumulate in BALT [102]. This is analogous to the kinetic observation of virus-activated DCs in the airways migrating from the epithelium to BALT [40].
Rheumatoid arthritis (RA) and Sjögren’s syndrome (SS) are autoimmune disorders characterized by the formation of ectopic lymphoid follicles in target tissues. Ectopic lymphoid follicles in the joints are common in patients with RA [103]; whereas ectopic follicles in the salivary and lacrimal glands are common in those with SS [104]. These follicles are hypothesized to contain separate B- and T-cell domains, germinal centers, FDCs, and HEVs, and they contribute toautoimmunity by generating high-affinity autoreactive B cells and sparing autoreactive effector T cells. BALT areas are observed in lung biopsies from a subset of patients with RA and SS who develop lung disease. It has been suggested to range from very small isolated lymphoid follicles to large, highly organized clusters of B-cell follicles [61].
BALT formation is frequently linked to lung inflammation and exposure to a variety of inflammatory stimuli. Therefore, it is not surprising that experimental exposure to an inflammatory agent via the pulmonary route results in BALT hyperplasia in rats. However, it is possible that an inflammatory agent, which has been linked to tumorigenesis, could also cause pulmonary adenocarcinoma [105]. Therefore, inflammatory responses in the lung can promote BALT and neoplasia at the same time. Indeed, considering the links between chronic inflammation and cancer development [106], it seems probable that BALT formation precedes tumorigenesis in such cases [48].
Local immune responses to pulmonary pathogens and antigens are clearly associated with BALT formation; thus, it is predicted that BALT development adjacent to pulmonary malignancies would also be beneficial for antitumor immune responses. A study demonstrated tertiary lymphoid tissue neogenesis induced by lymphotoxin: antitumor antibody fusion protein with the accumulations of CD4+ and CD8+ T cells, B cells, and PNAd-expressing HEVs [107]. Thus, it was hypothesized that the immune response necessary for tumor eradication was produced locally in tertiary lymphoid tissues [108]. Therefore, it is concluded that local BALT induction surrounding pulmonary metastases may be beneficial in inducing antitumor immunity and tumor regression [48].
In addition, it is suggested that the development of a lymphoid environment surrounding tumors may trigger antitumor immunity or immunological tolerance due to some unknown factors. Further, some studies indicate that lymphoid-like stromal elements surrounding tumors can impair antitumor immunity and lead to tolerance [109]. Despite the discrepancies and gaps in the literature, the ability of BALT to be spontaneously developed as a clear response to the development of pulmonary tumors or metastasis of other tumors to the lung as well as to boost immunity against lung tumors is an intriguing and research-worthy topic.
BALT covers a large area in the lungs, from small irregular lymphocytes and DC clusters to B-cell follicles, germinal centers, FDCs, HEV lymphatics, well-developed dome epithelium, and highly organized lymphoid tissues. It has the potential to help researchers better understand the mechanisms underlying chronic lung diseases, particularly in mammals. The potential contributions of BALT at this point are the collection of antigens from the pulmonary airways, priming B- and T-cell responses, and aiding in the clearance of pulmonary diseases. BALT becomes a functional tissue due to the induction of T cells and the production of deep lymphoid tissue, which functions in priming immune responses in the lung, including IgA-secreting plasma cells. The development of effective vaccines, particularly in the prevention of viral infections, will be aided by lymphoid tissue production.
This chapter was edited for English language by Crimson Interactive Inc. (Enago).
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Badria",profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",institutionString:"Mansoura University",institution:{name:"Mansoura University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9659",title:"Fibroblasts",subtitle:"Advances in Inflammation, Autoimmunity and Cancer",coverURL:"https://cdn.intechopen.com/books/images_new/9659.jpg",slug:"fibroblasts-advances-in-inflammation-autoimmunity-and-cancer",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Mojca Frank Bertoncelj and Katja Lakota",hash:"926fa6446f6befbd363fc74971a56de2",volumeInSeries:25,fullTitle:"Fibroblasts - Advances in Inflammation, Autoimmunity and Cancer",editors:[{id:"328755",title:"Ph.D.",name:"Mojca",middleName:null,surname:"Frank Bertoncelj",slug:"mojca-frank-bertoncelj",fullName:"Mojca Frank Bertoncelj",profilePictureURL:"https://mts.intechopen.com/storage/users/328755/images/system/328755.jpg",institutionString:"BioMed X Institute",institution:{name:"University Hospital of Zurich",institutionURL:null,country:{name:"Switzerland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8977",title:"Protein Kinases",subtitle:"Promising Targets for Anticancer Drug Research",coverURL:"https://cdn.intechopen.com/books/images_new/8977.jpg",slug:"protein-kinases-promising-targets-for-anticancer-drug-research",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"Rajesh Kumar Singh",hash:"6d200cc031706a565b554fdb1c478901",volumeInSeries:24,fullTitle:"Protein Kinases - Promising Targets for Anticancer Drug Research",editors:[{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8018",title:"Extracellular Matrix",subtitle:"Developments and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/8018.jpg",slug:"extracellular-matrix-developments-and-therapeutics",publishedDate:"October 27th 2021",editedByType:"Edited by",bookSignature:"Rama Sashank Madhurapantula, Joseph Orgel P.R.O. and Zvi Loewy",hash:"c85e82851e80b40282ff9be99ddf2046",volumeInSeries:23,fullTitle:"Extracellular Matrix - Developments and Therapeutics",editors:[{id:"212416",title:"Dr.",name:"Rama Sashank",middleName:null,surname:"Madhurapantula",slug:"rama-sashank-madhurapantula",fullName:"Rama Sashank Madhurapantula",profilePictureURL:"https://mts.intechopen.com/storage/users/212416/images/system/212416.jpg",institutionString:"Illinois Institute of Technology",institution:{name:"Illinois Institute of Technology",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9759",title:"Vitamin E in Health and Disease",subtitle:"Interactions, Diseases and Health Aspects",coverURL:"https://cdn.intechopen.com/books/images_new/9759.jpg",slug:"vitamin-e-in-health-and-disease-interactions-diseases-and-health-aspects",publishedDate:"October 6th 2021",editedByType:"Edited by",bookSignature:"Pınar Erkekoglu and Júlia Scherer Santos",hash:"6c3ddcc13626110de289b57f2516ac8f",volumeInSeries:22,fullTitle:"Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects",editors:[{id:"109978",title:"Prof.",name:"Pınar",middleName:null,surname:"Erkekoğlu",slug:"pinar-erkekoglu",fullName:"Pınar Erkekoğlu",profilePictureURL:"https://mts.intechopen.com/storage/users/109978/images/system/109978.jpg",institutionString:"Hacettepe University",institution:{name:"Hacettepe University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Proteomics",value:18,count:4},{group:"subseries",caption:"Metabolism",value:17,count:6},{group:"subseries",caption:"Cell and Molecular Biology",value:14,count:9},{group:"subseries",caption:"Chemical Biology",value:15,count:13}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:8},{group:"publicationYear",caption:"2021",value:2021,count:7},{group:"publicationYear",caption:"2020",value:2020,count:12},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:2}],authors:{paginationCount:250,paginationItems:[{id:"274452",title:"Dr.",name:"Yousif",middleName:"Mohamed",surname:"Abdallah",slug:"yousif-abdallah",fullName:"Yousif Abdallah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274452/images/8324_n.jpg",biography:"I certainly enjoyed my experience in Radiotherapy and Nuclear Medicine, particularly it has been in different institutions and hospitals with different Medical Cultures and allocated resources. Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"243698",title:"Dr.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:null,institution:null},{id:"7227",title:"Dr.",name:"Hiroaki",middleName:null,surname:"Matsui",slug:"hiroaki-matsui",fullName:"Hiroaki Matsui",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Tokyo",country:{name:"Japan"}}},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"92",type:"subseries",title:"Health and Wellbeing",keywords:"Ecology, Ecological, Nature, Health, Wellbeing, Health production",scope:"
\r\n\tSustainable approaches to health and wellbeing in our COVID 19 recovery needs to focus on ecological approaches that prioritize our relationships with each other, and include engagement with nature, the arts and our heritage. This will ensure that we discover ways to live in our world that allows us and other beings to flourish. We can no longer rely on medicalized approaches to health that wait for people to become ill before attempting to treat them. We need to live in harmony with nature and rediscover the beauty and balance in our everyday lives and surroundings, which contribute to our well-being and that of all other creatures on the planet. This topic will provide insights and knowledge into how to achieve this change in health care that is based on ecologically sustainable practices.
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