Speech and language impairments distribution (unpublished data from Suceava—Romania Regional Speech Therapy Centre).
\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5533",leadTitle:null,fullTitle:"The Role of the Clinical Cardiac Electrophysiologist in the Management of Congestive Heart Failure",title:"The Role of the Clinical Cardiac Electrophysiologist in the Management of Congestive Heart Failure",subtitle:null,reviewType:"peer-reviewed",abstract:"The world of clinical cardiac electrophysiology continues to evolve with newer and more advanced technologies to better serve our patients. In this book, titled The Role of the Clinical Cardiac Electrophysiologist in the Management of Congestive Heart Failure, authors from around the world have contributed their thoughts. Various chapters describing the use of biventricular pacing devices (CRT) in the management of patients suffering from systolic heart failure are included, with a chapter dedicated to management of CRT. A chapter describing the role of CRT in patients with Chagas disease is included. Authors describe the newer pharmaceuticals in the management of this disease and the role of catheter ablation in the management of atrial fibrillation and other arrhythmias. These topics are of great interest to clinicians at the various levels of training, and I believe this textbook gives a flavor of the expanding role of the electrophysiologist in the management of an ever-expanding patient population.",isbn:"978-953-51-2948-6",printIsbn:"978-953-51-2947-9",pdfIsbn:"978-953-51-7339-7",doi:"10.5772/63292",price:119,priceEur:129,priceUsd:155,slug:"the-role-of-the-clinical-cardiac-electrophysiologist-in-the-management-of-congestive-heart-failure",numberOfPages:168,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"72992f70d4e3ffcae4aa03439ea54954",bookSignature:"John Kassotis",publishedDate:"February 15th 2017",coverURL:"https://cdn.intechopen.com/books/images_new/5533.jpg",numberOfDownloads:12188,numberOfWosCitations:1,numberOfCrossrefCitations:0,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:1,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:2,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 17th 2016",dateEndSecondStepPublish:"June 7th 2016",dateEndThirdStepPublish:"September 3rd 2016",dateEndFourthStepPublish:"December 2nd 2016",dateEndFifthStepPublish:"January 31st 2017",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"146888",title:"Dr.",name:"John",middleName:null,surname:"Kassotis",slug:"john-kassotis",fullName:"John Kassotis",profilePictureURL:"https://mts.intechopen.com/storage/users/146888/images/system/146888.png",biography:"Dr. John Kassotis received his doctorate in chemical engineering from the Columbia University, School of Engineering and Applied Sciences, in 1985 and earned his MD degree from the Columbia College of Physicians and Surgeons in 1990. After completing his residency, cardiovascular fellowship, and electrophysiology fellowship at the Presbyterian Hospital, Dr. Kassotis began the Arrhythmia Service at New York Methodist Hospital (clinical affiliate of the NY Presbyterian Hospital Network) where he served as the director. In 2005, Dr. Kassotis was appointed the director of the Clinical Cardiac Electrophysiology Section and Fellowship Programs at SUNY Downstate Medical Center. He has authored or coauthored over 70 peer-reviewed articles, book chapters, and patents. He is the recipient of multiple teaching awards and serves as associate editor of the journal Cardiology.",institutionString:"Rutgers University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Rutgers, The State University of New Jersey",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"986",title:"Clinical Cardiac Electrophysiology",slug:"clinical-cardiac-electrophysiology"}],chapters:[{id:"54032",title:"Role of New Therapies in Reducing Mortality and Major Morbidity in Patients with Systolic Heart Failure",doi:"10.5772/66284",slug:"role-of-new-therapies-in-reducing-mortality-and-major-morbidity-in-patients-with-systolic-heart-fail",totalDownloads:1926,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Though heart failure therapies, particularly for systolic heart failure, have developed rapidly and markedly during the past four decades, a need for additional relief persists and is progressively being met. Two new drugs have been approved for marketing in the United States within the past two years, and two other glucose lowering therapies for diabetes appear to have efficacy for heart failure as well. In addition, device therapy for heart failure has progressed markedly during the past 5 years, particularly in refinements of the indications and applications of devices to minimize symptoms and hospitalizations and to maximize survival. This chapter will outline these recent developments.",signatures:"Oleg Yurevich and Jeffrey S. Borer",downloadPdfUrl:"/chapter/pdf-download/54032",previewPdfUrl:"/chapter/pdf-preview/54032",authors:[{id:"195160",title:"Dr.",name:"Jeffrey",surname:"Borer",slug:"jeffrey-borer",fullName:"Jeffrey Borer"},{id:"195161",title:"Dr.",name:"Oleg",surname:"Yurevich",slug:"oleg-yurevich",fullName:"Oleg Yurevich"}],corrections:null},{id:"53990",title:"Sympathetic Blockade for Dysrhythmia Management in Heart Failure: Rationale and Therapeutic Progression to Intervention",doi:"10.5772/66517",slug:"sympathetic-blockade-for-dysrhythmia-management-in-heart-failure-rationale-and-therapeutic-progressi",totalDownloads:1165,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Continuous ganglionic blockade is being used increasingly to help manage ventricular tachydysrhythmias. The purpose of this chapter is to discuss the physiologic and anatomic basis of ventricular tachydysrhythmias in detail that are mediated by the sympathetic nervous system and to discuss appropriate indications for the use of sympathetic ganglion blocks. These blocks can be instituted as both destination and bridging therapeutic options to control these dysrhythmias. These blocks therefore have value in the heart failure patient population since they offer a means of controlling the dysrhythmias that can be devastating to an already compromised myocardium.",signatures:"Daryl I. Smith and Albert O. Duah",downloadPdfUrl:"/chapter/pdf-download/53990",previewPdfUrl:"/chapter/pdf-preview/53990",authors:[{id:"191972",title:"Dr.",name:"Daryl",surname:"Smith",slug:"daryl-smith",fullName:"Daryl Smith"},{id:"195361",title:"Dr.",name:"Albert",surname:"Duah",slug:"albert-duah",fullName:"Albert Duah"}],corrections:null},{id:"53558",title:"The Impact of Cardiac Resynchronization Therapy in the Treatment of Heart Failure",doi:"10.5772/66947",slug:"the-impact-of-cardiac-resynchronization-therapy-in-the-treatment-of-heart-failure",totalDownloads:1291,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The number of patients who suffer from heart failure is rapidly increasing. In about one‐third of heart failure patients, conduction delays cause dyssynchronous left ventricular contractions, which leads to reduction in left ventricular function, adverse cardiac remodelling and finally increased mortality. Cardiac resynchronization involves simultaneous pacing of both ventricles, and improves left ventricular contractile function. Although resynchronization does not restore myocardial function, multiple studies have shown that cardiac resynchronization therapy improves quality of life, exercise capacity, symptoms of heart failure, left ventricular ejection fraction, morbidity and mortality. The use of cardiac resynchronization therapy has increased significantly, since its initial approval in 2001, in patients with advanced heart failure.",signatures:"Takashi Murashita",downloadPdfUrl:"/chapter/pdf-download/53558",previewPdfUrl:"/chapter/pdf-preview/53558",authors:[{id:"192448",title:"Dr.",name:"Takashi",surname:"Murashita",slug:"takashi-murashita",fullName:"Takashi Murashita"}],corrections:null},{id:"53765",title:"Cardiac Resynchronization Therapy in Advanced Heart Failure: Predictors of Response and Optimization of Therapy",doi:"10.5772/67037",slug:"cardiac-resynchronization-therapy-in-advanced-heart-failure-predictors-of-response-and-optimization-",totalDownloads:1398,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Heart failure affects a high percentage of the population, especially older patients. Cardiac resynchronization therapy is indicated in some patients with advanced heart failure. However, 20–40% of patients with implanted resynchronization device have no clinical response. In this chapter, we review factors related with the absence of a clinical response, recent technological advances that can reduce the failure rate, and an algorithm for management of patients without a clinical response.",signatures:"García García Miguel Ángel, Martínez Cornejo Alfonso and Rosero\nArenas María de los Ángeles",downloadPdfUrl:"/chapter/pdf-download/53765",previewPdfUrl:"/chapter/pdf-preview/53765",authors:[{id:"192810",title:"Dr.",name:"Miguel Ángel",surname:"García García",slug:"miguel-angel-garcia-garcia",fullName:"Miguel Ángel García García"}],corrections:null},{id:"53928",title:"Utility of Cardiac Implantable Electronic Devices in Patients with Chagas Disease and Systolic Heart Failure",doi:"10.5772/67079",slug:"utility-of-cardiac-implantable-electronic-devices-in-patients-with-chagas-disease-and-systolic-heart",totalDownloads:1388,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Chagas disease (CD) is the principal cause of congestive heart failure (CHF) in areas where the disease is endemic and migration has increased the likelihood of these diseases being the probable cause of CHF in other countries of the world. Sudden cardiac death (SCD) is the most common cause of death in CD (55–65%). Implantable cardioverter defibrillator (ICD) is useful in the secondary prevention of SCD, but there is less information regarding primary prevention. The evidence supporting the use of cardiac resynchronization therapy (CRT) in CHF of chagasic etiology is poor; however, one should apply current guidelines regarding the insertion of these devices in patients with Chagas disease and CHF.",signatures:"Guillermo Mora",downloadPdfUrl:"/chapter/pdf-download/53928",previewPdfUrl:"/chapter/pdf-preview/53928",authors:[{id:"192796",title:"Prof.",name:"Guillermo",surname:"Mora",slug:"guillermo-mora",fullName:"Guillermo Mora"}],corrections:null},{id:"53821",title:"Transcatheter Ablation of Atrial Fibrillation in Patients with Chronic Heart Failure",doi:"10.5772/67024",slug:"transcatheter-ablation-of-atrial-fibrillation-in-patients-with-chronic-heart-failure",totalDownloads:1531,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Atrial fibrillation (AF) is the most frequent of all cardiac arrhythmias and it is associated with an increased risk of stroke, systemic embolism and heart failure. Patients with AF have a twofold increased risk of death and fivefold increased risk of stroke compared with those without AF. In patients with heart failure (HF), AF ablation improves left ventricular (LV) function over short- and long-term follow-ups, especially compared with medical treatment. Furthermore, AF ablation in HF patients relates to a significant improvement in quality of life, functional class and exercise tolerance, possibly related to the improvement in LV function and hemodynamic status of the patients. Finally, data showed that restoration of sinus rhythm in this setting of patients reduced the incidence of stroke and death. In this review, we reported all the major data regarding atrial fibrillation therapy in patients with heart failure.",signatures:"Antonio Di Monaco, Federico Quadrini, Nicola Vitulano and\nMassimo Grimaldi",downloadPdfUrl:"/chapter/pdf-download/53821",previewPdfUrl:"/chapter/pdf-preview/53821",authors:[{id:"192460",title:"Ph.D.",name:"Massimo",surname:"Grimaldi",slug:"massimo-grimaldi",fullName:"Massimo Grimaldi"},{id:"195372",title:"Dr.",name:"Antonio",surname:"Di Monaco",slug:"antonio-di-monaco",fullName:"Antonio Di Monaco"},{id:"195373",title:"Dr.",name:"Federico",surname:"Quadrini",slug:"federico-quadrini",fullName:"Federico Quadrini"},{id:"195374",title:"Dr.",name:"Nicola",surname:"Vitulano",slug:"nicola-vitulano",fullName:"Nicola Vitulano"}],corrections:null},{id:"53423",title:"Role of the Electrophysiologist in the Treatment of Tachycardia-Induced Cardiomyopathy",doi:"10.5772/66515",slug:"role-of-the-electrophysiologist-in-the-treatment-of-tachycardia-induced-cardiomyopathy",totalDownloads:1539,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Tachycardia-induced cardiomyopathy is a systolic cardiac dysfunction given by prolonged elevated heart rates in patients with incessant or frequent tachyarrhythmias. Arrhythmias associated with tachycardiomyopathy can be either supraventricular (atrial tachycardia, atrial flutter, atrial fibrillation, AVNRT, permanent junctional reciprocating tachycardia, high rates of atrial pacing) or ventricular (frequent premature ventricular complexes, right ventricular outflow tract tachycardia, LVOT, left ventricular fascicular tachycardia, bundle-branch reentry or high rate of ventricular pacing). Electrophysiological study confirms the clinical diagnosis of tachycardia-induced cardiomyopathy, reveals the arrhythmia mechanism and facilitates catheter ablation that results in complete recovery of ventricular function. This chapter has two parts: 1. Theoretical insight into the pathogenesis of tachycardia-induced cardiomyopathy, clinical manifestations and therapy. 2. Practical issues: we describe our EP lab’s experience on electrophysiological study and ablation in patients with tachycardia-induced cardiomyopathy. We will present five cases of ablation: PVCs >30,000/24 h, antidromic tachycardia, 2:1 atrial flutter, persistent atrial fibrillation and RVOT PVCs with nonsustained VT.",signatures:"Cismaru Gabriel, Lucian Muresan, Puiu Mihai, Radu Rosu, Gabriel\nGusetu, Dana Pop and Dumitru Zdrenghea",downloadPdfUrl:"/chapter/pdf-download/53423",previewPdfUrl:"/chapter/pdf-preview/53423",authors:[{id:"191888",title:"Dr.",name:"Gabriel",surname:"Cismaru",slug:"gabriel-cismaru",fullName:"Gabriel Cismaru"},{id:"195419",title:"Dr.",name:"Lucian",surname:"Muresan",slug:"lucian-muresan",fullName:"Lucian Muresan"},{id:"195420",title:"Dr.",name:"Mihai",surname:"Puiu",slug:"mihai-puiu",fullName:"Mihai Puiu"},{id:"195421",title:"Dr.",name:"Radu",surname:"Rosu",slug:"radu-rosu",fullName:"Radu Rosu"},{id:"195422",title:"Dr.",name:"Gabriel",surname:"Gusetu",slug:"gabriel-gusetu",fullName:"Gabriel Gusetu"},{id:"195423",title:"Prof.",name:"Dana",surname:"Pop",slug:"dana-pop",fullName:"Dana Pop"},{id:"195424",title:"Prof.",name:"Dumitru",surname:"Zdrenghea",slug:"dumitru-zdrenghea",fullName:"Dumitru Zdrenghea"}],corrections:null},{id:"52978",title:"Impact of Thyroid Disease on Heart Failure",doi:"10.5772/66283",slug:"impact-of-thyroid-disease-on-heart-failure",totalDownloads:1953,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The modern vision concerning the physiological actions and pathological relevance of endocrine cardiac system is a very complex one. Decreased or increased action of thyroid hormone (hypo‐ or hyperthyroidism) on different cellular and molecular pathways in the heart plays an important role in the development and progression of myocardial remodelling and heart failure. Cardiovascular signs and symptoms that accompany both hyperthyroidism and hypothyroidism are presented, highlighting that correction of thyroid dysfunction most often reverses the abnormal cardiovascular hemodynamics.",signatures:"Adina Elena Stanciu, Adina Zamfir‐Chiru‐Anton, Marcel Marian\nStanciu and Dan Cristian Gheorghe",downloadPdfUrl:"/chapter/pdf-download/52978",previewPdfUrl:"/chapter/pdf-preview/52978",authors:[{id:"193244",title:"Dr.",name:"Adina Elena",surname:"Stanciu",slug:"adina-elena-stanciu",fullName:"Adina Elena Stanciu"},{id:"195352",title:"Dr.",name:"Adina",surname:"Zamfir-Chiru-Anton",slug:"adina-zamfir-chiru-anton",fullName:"Adina Zamfir-Chiru-Anton"},{id:"195355",title:"Prof.",name:"Marcel",surname:"Stanciu",slug:"marcel-stanciu",fullName:"Marcel Stanciu"},{id:"195356",title:"Dr.",name:"Dan-Cristian",surname:"Gheorghe",slug:"dan-cristian-gheorghe",fullName:"Dan-Cristian Gheorghe"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"997",title:"Tachycardia",subtitle:null,isOpenForSubmission:!1,hash:"1a5908b405f4ffb028f51f29863469d0",slug:"tachycardia",bookSignature:"Takumi Yamada",coverURL:"https://cdn.intechopen.com/books/images_new/997.jpg",editedByType:"Edited by",editors:[{id:"68148",title:"Prof.",name:"Takumi",surname:"Yamada",slug:"takumi-yamada",fullName:"Takumi Yamada"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4584",title:"Abnormal Heart Rhythms",subtitle:null,isOpenForSubmission:!1,hash:"81532d7ef92dec2fed90a8c7ea7a051c",slug:"abnormal-heart-rhythms",bookSignature:"Francisco R. Breijo-Marquez",coverURL:"https://cdn.intechopen.com/books/images_new/4584.jpg",editedByType:"Edited by",editors:[{id:"63299",title:"Prof.",name:"Francisco R.",surname:"Breijo-Marquez",slug:"francisco-r.-breijo-marquez",fullName:"Francisco R. Breijo-Marquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3528",title:"Cardiac Surgery",subtitle:"A Commitment to Science, Technology and Creativity",isOpenForSubmission:!1,hash:"95973b4f0e34524407c79ddb123a0d09",slug:"cardiac-surgery-a-commitment-to-science-technology-and-creativity",bookSignature:"Miguel Angel Maluf and Paulo Roberto Barbosa Evora",coverURL:"https://cdn.intechopen.com/books/images_new/3528.jpg",editedByType:"Edited by",editors:[{id:"106872",title:"Prof.",name:"Miguel",surname:"Maluf",slug:"miguel-maluf",fullName:"Miguel Maluf"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3815",title:"Cardiac Arrhythmias",subtitle:"Mechanisms, Pathophysiology, and Treatment",isOpenForSubmission:!1,hash:"fe6dad804d0257a3922593b7861a1b74",slug:"cardiac-arrhythmias-mechanisms-pathophysiology-and-treatment",bookSignature:"Wilbert S. Aronow",coverURL:"https://cdn.intechopen.com/books/images_new/3815.jpg",editedByType:"Edited by",editors:[{id:"164597",title:"Dr.",name:"Wilbert S.",surname:"Aronow",slug:"wilbert-s.-aronow",fullName:"Wilbert S. 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Elwing and Ralph J. 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\r\n\tToday, scientists describe the Universe mainly in terms of two theories: (1) Einstein's general theory of relativity (GTR), which describes the force of gravity and the large-scale structure of the Universe, and (2) quantum mechanics (QM), which describes the physics of the very small. However, as emphasized by Stephen Hawking and others, these two theories are known to be inconsistent with each other, so one needs to accommodate the gravitational force within the domain of QM by developing a quantum theory of gravity that will apply to both the large and small scales of the Universe. In a recent book entitled "The God Equation: The Quest for a Theory of Everything, Michio Kaku discusses the history and the nature of such a theory, which made significant progress during the 20th century through the development of the Standard Model (SM) of particle physics that represented the best understanding of the subatomic world at that time. Unfortunately, the SM makes no mention of the gravitational force. However, by removing several dubious assumptions made during the development of the SM, an alternative model, the Generation Model (GM), was developed from 2002-to 2019. The GM proposes that the gravitational force is not a fundamental force, as believed for centuries, but is a universal attractive, very weak residual interaction of the strong nuclear force, acting between the three massive particles, the proton, the neutron, and the electron, which are the constituents of a body of ordinary matter: this residual force provides a quantum theory of gravity. The main aim of this book is to discuss both the flaws of the SM and the GTR and also the considerable successes of the GM.
",isbn:"978-1-83768-018-4",printIsbn:"978-1-83768-017-7",pdfIsbn:"978-1-83768-019-1",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"085d4f6e00016fdad598675f825d6775",bookSignature:"Prof. Brian Albert Robson",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11861.jpg",keywords:"Standard Model, Twelve Elementary Particles, Higgs Boson Research, Universal Weak Force, CP-Violating Research, Big Bang Theory, Dark Matter, Dark Energy, Modified Gravity, Massless Elementary Particles, Quarks in Hadrons, Mixed Parity States",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 10th 2022",dateEndSecondStepPublish:"July 13th 2022",dateEndThirdStepPublish:"September 11th 2022",dateEndFourthStepPublish:"November 30th 2022",dateEndFifthStepPublish:"January 29th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"10 days",secondStepPassed:!1,areRegistrationsClosed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"A pioneering researcher in theoretical nuclear physics and the scattering of polarized particles, recognized by Marquis Who’s Who Top Scientists for achievements and leadership in education and research. More recently, developed the Generation Model as a successful alternative to the Standard Model of particle physics. This model led to a fully quantum theory of gravity. Dr. Robson is a member of the editorial board for the Scientific World Journal and the Open Nuclear and Particle Physics Journal.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"102886",title:"Prof.",name:"Brian Albert",middleName:null,surname:"Robson",slug:"brian-albert-robson",fullName:"Brian Albert Robson",profilePictureURL:"https://mts.intechopen.com/storage/users/102886/images/system/102886.jpeg",biography:"Professor Brian Albert Robson obtained MSc, PhD and DSc degrees in Physics from the University of Melbourne, Australia. He is a Fellow of both the Australian Institute of Physics and the UK Institute of Physics. Currently he is an Honorary Professor in the Research School of Physics, The Australian National University, Canberra. During his academic career, he served for four years as Officer-in-Charge of the Australian National University’s first computer, for nine years as Head of the Department of Theoretical Physics, and for two years as Associate Director of the Research School of Physics and Engineering. Professor Robson has published more than 150 scientific publications mainly in the areas of nuclear physics, particle physics, gravitation and cosmology.",institutionString:"The Australian National University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Australian National University",institutionURL:null,country:{name:"Australia"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"20",title:"Physics",slug:"physics"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"466998",firstName:"Dragan",lastName:"Miljak",middleName:"Anton",title:"Mr.",imageUrl:"https://mts.intechopen.com/storage/users/466998/images/21564_n.jpg",email:"dragan@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. 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Dyslalia can be simple when it is related with only one sound (eventually in an attenuated form). An extension of pronunciation–articulation disorder related with more sounds and/or groups of syllables is called polymorphic dyslalia [1].
\nThe existence of a dyslalia with defectological significance can be diagnosed after the age of four. Until that, dyslalia is called physiological and it is caused by the insufficient development of the speech‐articulator apparatus and the neurological systems implicated in the speech process. This is the age that allows maximization of the therapeutic effects and offers a good prognosis for improvement/correction. The later the therapy begins, the weaker the effect [2].
\nThere are many causes for dyslalia: the imitation of persons with deficient pronunciation, lack of speech stimulation, adults encouraging the preschool child to stabilize wrongful habits, defects in teeth implantation, different anomalies of the speech‐articulator apparatus, cerebral deficiencies, hearing loss, weak development of phonetic hearing. Also, in severe dyslalias, heredity is considered an important factor in diagnosing and explaining this deficiency.
\nImpairment type | \nNumber of subjects | \nImpairment frequency (%) | \nOverall impairment frequency (%) | \n|
---|---|---|---|---|
434 | \n91.2 | \n14.8 | \n||
– | \n– | \n– | \n||
7 | \n1.5 | \n0.2 | \n||
– | \n– | \n– | \n||
17 | \n3.7 | \n0.6 | \n||
Selective mutism | \n4 | \n0.8 | \n0.1 | \n|
General development delays | \n8 | \n1.6 | \n0.3 | \n|
– | \n– | \n– | \n||
Autism | \n4 | \n0.8 | \n0.1 | \n|
Down syndrome | \n2 | \n0.4 | \n0.1 | \n|
Intellectual deficiencies | \n– | \n– | \n– | \n|
Deafness | \n– | \n– | \n– | \n|
476 | \n100.0 | \n16.2 | \n
Speech and language impairments distribution (unpublished data from Suceava—Romania Regional Speech Therapy Centre).
In dyslalia, the sounds are not equally affected. Thus, the sounds most affected are the ones that appear later in the child\'s speech: vibrant—r (very important in Romanian language), affricates—c, g, t, hissing—s, z. In fact, the sounds mostly affected are the ones that require a greater effort to synchronize the elements of the phono‐articulator apparatus (elements engaged in the emission of sounds: larynx, vocal cords, tongue, lips, teeth, and cheeks). Their pronunciation involves a certain position of all these elements and a certain intensity of the exhausted air jet [1].
\nRegarding the frequency of speech impediments and especially the frequency of dyslalia, the statistics from the Suceava Romanian Regional Speech Therapy Centre (Table 1; Figure 1) reveals the following aspects [2]: (i) Disorders that affect speech are more frequent that the ones affecting the language; (ii) Dyslalia is the most frequent pronunciation disorder, with sounds r and s most affected; (iii) the proportion of children with speech impediments:\n
Decreases constantly until first grade;
Suddenly decreases between first and second grade;
Decreases slower and slower between second and fourth grade.
Evolution of speech impairments frequency across subjects’ age.
The characterization of the dyslalia dynamics is of great interest also, in regard to the age of the subjects as depicted in Figure 1. Before age four no logopedic evaluation was conducted for children since possible speaking problems might be due to insufficient maturation of the phono‐articulatory organs and of the involved cortical areas.
\nAfter this age, children with speech impairments are integrated in the speech therapy programs. The therapy determines the progressive decrease of the proportion of children with speech problems in relation to their age. At the beginning of the school, the frequency of children with speech disorders decreases suddenly, mainly because of the acquisition of writing and reading skills. Moreover, the corrective effort from the teaching community is highly emphasized. After this age, language disorders are present mainly in children with organ related disorders—structural disorders of the central or peripheral organs of speech.
\nThe main steps of speech therapy together with the place of fuzzy expert system in therapeutic process are presented in Figure 2. Each therapy process contains a formative evaluation, which can be followed by the therapy within the family. After 3 months, the speech therapist can finalize the therapy or can reevaluate it [3].
\nThe expert system incorporates information generated from social, cognitive, and affective examination, as well as from the homework reports and results’ trends [4]. This allows the expert system to provide critical answers related to the length and frequency of the therapy session as well as the type of exercise to be used and its content.
\nSpeech therapy process and fuzzy expert system [
The therapy customization assumes a differentiated report related to the therapy stages. Thus, for each subject, there are different weights for each stage within the program structure. The therapy is generally a formative assessment because the speech therapists permanently evaluate the evolution of the patient during the exercises. The therapy is continued in familial environment during home training sessions. Thus, between the weekly sessions, family must provide the child with the adequate environment to consolidate the skills initiated at the specialty clinic.
\nA summative assessment is conducted every 3 months, and the child\'s evolution is analyzed over a longer period of time. This is the time for the reconsideration of the therapy and, eventually, for finalizing the therapeutic process.
\nThe expert system is designed to function as a true assistant of the speech therapist. It provides suggestions based on several recordings from the integrated system. Moreover, depending on the assessments performed by the speech therapist at each session and on the homework solving, the human expert receives suggestions regarding the most appropriate exercises to recommend [5].
\nIt is necessary for the speech therapist to have the possibility to intervene in modifying the knowledge database when the suggestion given by the expert system contradicts the speech therapist decision. The system has to self‐notify the presence of a contradiction and to ask the human expert to remove the conflict. This principle is useful for the therapeutic system (in general) and for the expert system (in particular), especially in the case of the beginner speech therapist (with less practical training experience). Even if the computer decisions cannot be considered absolutely correct, they can contribute to the overall success of the therapy by raising questions which require further clarifications by consulting a human expert.
\nArchitecture of Logomon CBST.
Since 2006 we have developed Logomon, the computer‐based speech therapy system (CBST) for Romanian language. The modules of the integrated system are briefly presented in Figure 3 (modules 1,…,9). All administrative tasks are grouped in the Lab Monitor Application. The expert system takes the information it needs from the database of this module. In the first scenario, the child exercises in SLT\'s Lab using Lab Monitor Application.
\nAnother scenario involves the utilization of a dynamic 3D model, a module that indicates the correct positioning of elements of phono‐articulator apparatus for each phoneme in Romanian language (the model can translate and rotate; the transparency of each individual elements—teeth, tongue, cheeks—can also be modified). Homework is mainly generated by the fuzzy expert system that indicates the number, the duration, and the content of home exercises. These exercises are played on a mobile device (Home Monitor), without SLT intervention [6]. The relations between input and output variables are presented in Figure 4.
\nThe relation between input and output variables.
The expert system is fed with information taken from three sources: socio‐psychological parameters (Lab Monitor Application), tests scores (Lab Exercises), and homework scores (Home Monitor). These numbers are grouped in nine input variables [3].\n
number of affected phonemes (in order to differentiate between simple and polymorphic dyslalia);
average test score (indicates the intensity of impairment);
parents’ attitude regarding speech impairment (the parents’ attitude is a key factor in therapy prognosis);
parents–child relation (offer important clues regarding the importance of home training sessions);
relation between parents (describes the emotional quality of familial environment);
child\'s age (the therapeutical strategy largely vary with subject\'s age);
child\'s attention (this variable was taken into consideration due to increasing frequency of ADHD—attention deficit disorders—among the children);
collateral diseases (AIDS, Down syndrome, intellectual disabilities, nutrition diseases);
psychological trauma (shows the child\'s emotional health).
The expert system outputs five numbers that configure the personalized therapy:\n
number of weekly sessions (how many times in a week the child should encounter SLT?);
number of homeworks (how many homework sessions should be?);
duration of a homework (how long a homework should last?);
collaboration with family (should SLT rely on child\'s family support?);
collaboration with physician (does SLT have to collaborate with a physician?).
One major limitation of such a system is the inability to express and/or mimic emotions such as empathy and to recognize emotional states. To improve this, some studies used the human–computer interaction (HCI) model in which trained individuals reflecting a particular emotional state are used. In our previous work, we explored the possibility of adapting and integrating the classical techniques of emotion recognition in the assisted therapy for children with speech problems [6].
\nThe fuzzy expert system is based on forward chaining of over 200 rules written in fuzzy control language (FCL). The expert system engine is coded in Java language and is integrated in our speech therapy platform. In order to adjust and validate the inferential process, we used our platform for more than 100 children from 2008 to 2015. The extension of our system using an artificial neural network (ANN) is demanding especially because it is relative hard for a SLT to change a fuzzy rule. Thus, in the case of a contradiction between human and artificial expert, an ANN could facilitate the re‐training process [7, 8].
\nBecause of the emergence of interdisciplinary technologies during the past few years, the interaction between doctors and engineers opened unprecedented opportunities, and the medical specialists are employing computerized technologies to assist in diagnosis of, and access to, related medical information.
\nThe rapid progress in computer technology plays a key role in the development of medical diagnostic tools that call for the need of more advanced intelligent and knowledge‐based systems [9]. This is important since medical diagnosis is characterized by a high degree of uncertainty that can be improved through the application of fuzzy techniques that provide powerful decision support, expert systems knowledge, and enhanced reasoning capabilities in the decision‐making process. Also, it provides a powerful framework for the combination of evidence and deduction of consequences based on knowledge stored in the knowledge base [9]. Therefore, fuzzy expert system (FES) can be used in applications for diagnosis, patient monitoring and therapy, image analysis, differential diagnosis, pattern recognition, medical data analysis [10–14].
\nThe areas in which diversified applications are developed using fuzzy logic are fuzzy models for illness, heart and cardiovascular disease diagnosis, neurological diseases, asthma, abdominal pain, tropical diseases, medical analogy of consumption of drugs, diagnosis and treatment of diabetes, syndrome differentiation, diagnosis of lung and liver diseases, monitoring and control in intensive care units and operation rooms, diagnosis of chronic obstructive pulmonary diseases, diagnosis of cortical malformation, etc. The non‐disease areas of applications are in X‐ray mammography, interpretation of mammographic and ultrasound images, electrographic investigation of human body. Other areas for the applications of fuzzy logic are prediction of aneurysm, fracture healing, etc.
\nRecent research studies have contributed to the development of diagnostic techniques, quantification of medical expertise, knowledge technology transfer, identification of usage patterns, and applications of FES in practice by the medical practitioners [15]. According to [15], 21% of studies present the development of methodologies and models and 13% studies contributed to the development of neuro‐fuzzy‐based expert systems [9]. These studies contributed to the development of innovative diagnostic techniques, quantification of medical expertise, and application of fuzzy expert systems and their implementation in practice.
\nFuzzy
The rationale behind the decision‐making process in medical diagnosis is a complex endeavor that involves a certain degree of uncertainty and ambiguity. The computer‐assisted expert system that incorporates the fuzzy model has been used to aid the physician in this process [15]. As such, several computer‐assisted applications for patient\'s diagnosis and treatments as well as web‐based FES have been recently developed and include ways of handling vagueness and complexity (Figure 5). Furthermore, disease‐focused intelligent medical systems are rapidly emerging and are designed to handle more complex variables such as patient monitoring, predictive values, as well as taking into account assessment and performance parameters.
\nThe architecture of a generic medical fuzzy expert system showing the flow of data through the system is depicted in Figure 6 [9]. The knowledge base for developed medical FES contains both static and dynamic information. There are qualitative and quantitative variables, which are analyzed to arrive at a diagnostic conclusion. The fuzzy logic methodology involves fuzzification, inference engine, and defuzzification as the significant steps [9].
\nThe architecture of a generic medical fuzzy expert system.
The FES uses both quantitative and qualitative analyses of medical data and represents a useful tool in achieving a high success rate in medical diagnosis. These computer‐based diagnostic tools together with the knowledge base have proved very useful in early diagnosis of pathologies. On the other hand, the web‐based applications and interfaces allow health practitioners to readily share their knowledge and know‐how expertise [15].
\nAn artificial neural network (ANN) is a computational model that attempts to account for the parallel nature of the human brain [16]. Analyzing approaches in different scientific procedures, the ability to learn, tolerance to data noises and capability to model incomplete data have made them unique, and once the network has been trained, new data in similar domain may be analyzed and predicted [17].
\nIn the medical field, ANN applications that have been developed use the “classification” principle‐based on which patients are assigned to a particular set of classes based on specific biological measures. For example, ANN applications have been used in the diagnosis of diabetes (using blood and urine analyses) [18, 19], tuberculosis [20, 21], leukemia [22], cardiovascular conditions [23] (such as heart murmurs [24]), liver [25], and pulmonary [26] diagnosis, as well as in urological dysfunctions [27], including expert pre‐diagnosis system for automatic evaluation of possible symptoms from the uroflow results [28], and ANN applications have also been used in image analyses [29, 30] and in analysis of complicated effusion samples [31]. Finally, a neural networks‐based automatic medical diagnosis system has been developed for eight different diseases [32], and in detection and diagnosis of micro‐calcifications in digital format mammograms [33].
\nAn ANN is a network of highly interconnecting processing elements (inspired by biological nervous systems—neurons) operating in parallel. The connections between elements largely determine the network function. A subgroup of processing element is a layer in the network. Each neuron in a layer is connected with each neuron in the next layer through a weighted connection [34]. The structure of a neural network is formed by layers. The first layer is the input layer, and the last layer is the output layer, and between them, there may be additional layer(s) of units (hidden layers) [16]. The number of neurons in a layer and the number of layers depend strongly on the complexity of the system studied [34]. Therefore, the optimal network architecture must be determined. The general scheme of a typical three‐layered ANN architecture is illustrated in Figure 7.
\nGeneral structure of a neural network (modify after [
Based on the way they learn, all artificial neural networks are divided into two learning categories: supervised and unsupervised. In unsupervised networks, the training procedure uses inputs only, and there are no known answers and the network must develop its own representation of the input stimuli by calculating the acceptable connection weights. On the other hand, training in the supervised learning involves both input and output patterns so that the neural weights can be changed to generate the desired output [16]. In medical applications, supervised networks may be used as alternatives to conventional response surface methodology (RSM) while the unsupervised ones can serve as alternatives to principal component analysis (PCA) in order to map multidimensional data sets onto two‐dimensional spaces [17].
\nModels from ANNs are multifactorial models which can predict, classify, approximate function, or recognize patterns. Theoretically, ANNs are able to estimate any function and if used properly, it can be used effectively in medicine. Outputs from artificial neural networks models are generated from nonlinear combinations of input variables, and such models can be effectively employed to deal with experimental data routinely observed in medicine and to find rules governing a process from raw input data [17].
\nThe development of intelligent systems in the health field is based on the complementarity between technologies that use the combination between fuzzy logic and neural networks models. This generated the neuro‐fuzzy model that takes advantage of both the capability in modeling uncertain data by the artificial neural networks as well as of handling qualitative knowledge. The neuro‐fuzzy approaches have been used in several studies to build more intelligent decision‐making systems as additional supportive tools for the physicians.
\nFor example, an application of artificial neural networks in typical disease diagnosis using a fuzzy approach was investigated in [35]. The real procedure of medical diagnosis which usually is employed by physicians was analyzed and converted to a machine implementable format. Similarly, in [16], a series of experiments were described and advantages of using a fuzzy approach were discussed.
\nNeuro‐fuzzy (NF) computing becomes a popular framework for solving complex problems based on knowledge expressed in linguistic rules for building a FES, and on data, for learning from a simulation (training) using ANNs. For building a FES, we have to specify the fuzzy sets, fuzzy operators, and the knowledge base. For constructing an ANN for an application, the user needs to specify the architecture and the learning algorithm. Both approaches have their own drawbacks, and they should be combined when building an integrated system [36]. This way we can take advantage of the learning capabilities, which is essential for the fuzzy expert system as well as the linguistic base knowledge that constitutes part of the artificial neural networks.
\nTherefore, FES and ANNs have attracted the attention of many scientists, and also a huge number of successful applications of them are found in the literature, reporting problems solving in various areas of sciences, such as computing, engineering, medicine, nanotechnology, environmental science, and business.
\nThe fuzzy expert systems (FES) and artificial neuronal network (ANN) have common origin and purposes. They may carry out the logical reasoning, simulating artificial intelligence, by combining the quantitative and qualitative information and meta‐knowledge. The advantages and disadvantages of these techniques are complementary. The main disadvantages of FES as regards to the acquisition of knowledge can be easily eliminated using ANN, due to its ability to learn from typical examples. On the other hand, limitations of the ANN related to the man–machine interface and capabilities to explain the reasoning leading to a certain conclusion can be theoretically compensated using the FES [10].
\nThe FES has the following properties: (i) sequential processing; (ii) the acquisition process of knowledge takes place outside the expert system; (iii) the logic is a deducible; (iv) the knowledge is presented in the explicit form; (v) the system is based on the knowledge acquired from human experts; (vi) the rules in the chain of the rules have their origin in the logic of mathematics and fuzzy logic; and (vi) the extraction of the conclusion (implementation of the diagnosis) is done by correlating the exact amount of information and data [10].
\nThe ANN, due to the fact that is designed according to the model of the human brain, has the ability: (i) to learn; (ii) has the advantage of a parallel processing; (iii) the acquisition of knowledge takes place inside the system; (iv) the logic is inductively; (v) the knowledge is the default and gained through examples; (vi), uses parameters and statistical methods for classification and data clustering; and (vii) the extraction of the learned conclusion is made by the approximate correlation of data.
\nA significant difference between the two instruments lies in the basis of reasoning. As such, the FES is based on the algorithms and deductions, while the ANN is based on the inference from simulating the learning mechanisms of specialized neurons. Based on the techniques used for processing information, the ESF uses sequential methods of processing while ANN has parallel processing, that is, each neuron performs functions in parallel with other neurons in the network.
\nIn the case of learning processes and reasoning in the FES, learning is made outside of the system and the knowledge is obtained from outside and then coded in the knowledge base. For ANN, the knowledge accumulates in the form of weights of the connections between the nodes (neurons), the learning process being internal, permanently adjusting the knowledge deployments as new examples. The FES is based on the method of deductive reasoning, unlike the ANN, in which the methods are inductive. The algorithms of inference of the FES are based on the logic of the sequence “forward or backward” method in the knowledge base, and the ANN uses the approximate correlation of the components of the knowledge base in order to return to items previously learned. The ANN may acquire knowledge through direct learning from examples, which constitutes an advantage, on the basis of algorithms of specific learning with the possibility to learn from the incomplete or partially incorrect or contradictory input data, having the capacity to generalize. On the other hand, the FES has the advantage of a friendly user interface with the possibility of incorporating elements of heuristic reasoning.
\nOne of the basic paradigms of artificial intelligence, with applications in the medical field, is to find a tool which will make it possible to the representation of a large number of meta‐knowledge, consistent, and usable for the user. There are two approaches of a computerized system based on knowledge: the first approach is one in which the field of knowledge representation is based on the rules. This involves the necessity that human experts extract rules from its experience and express them in the form of explicit and comprehensible rules. The system has the explanatory and perfect skills and performs well with incomplete information and inaccurate (fuzzy) using the factors of trust, but the construction of such base of knowledge is a difficult task.
\nThe second approach has a connection with the development of the theory of the neuronal networks which is automatically created by a learning algorithm from a variety of inference examples. The knowledge representation is based on the weights of the connections between the neurons. Due to the default representation of knowledge, there is no possibility to identify a problem at the level of the singular neuron. In this case, both working with incomplete information and the provision of evidence of the inference are limited.
\nFrom these considerations, combining fuzzy expert system with the neuronal networks will lay the base for the construction of a practical application for strategic decisions, (especially medical decisions), both tactical and operative, and will integrate the advantages of both types of information systems (neuro‐fuzzy system expert) [10].
\nThe main challenge in the integration of these two approaches is the creation of the knowledge base when they are only available the rules and examples of data. Additional problems may also occur when incomplete and unreliable information is encoded in neuronal networks. Therefore, it is necessary that the “learning” network is able to work with incomplete information during training in place of using of special heuristic inference.
\nThe inputs and outputs values in a neuro‐fuzzy expert system are coded using the analog statuses of neuronal values. An inference is a pair consisting of a vector of the typical inputs and the vector to the corresponding outputs obtained by the expert answers to these questions. Knowledge base of the neuro‐fuzzy expert system is a multilayer neuronal network.
\nTo solve the problems raised by the irrelevant values and unknown inputs and outputs of the expert system, the range neuron should be created. The value of the irrelevant or even unknown input and output of the expert system is coded using the full range of status of neurons.
\nThe expert systems become effective and efficient not only to resolve problems of high complexity but also for the decision‐making problems, which contain a high degree of uncertainty.
\nMore recently, a hybrid system that includes fuzzy logic, neuronal networks, and genetic algorithms has been developed this required inclusion of additional techniques. The fundamental concept of these hybrid systems consists in complementarity and addresses the weaknesses of each other. The fuzzy expert systems are appropriate especially in the case of systems that have a mathematical model that is difficult to comprehend, for example, when the values of the inputs and of the parameters are vague, imprecise, and/or incomplete. It facilitates the decision‐making process in the case of use of the estimated values for the inaccurate information (if the decision is not correct, it may be modified later when more information becomes available). Fuzzy models allow us to represent the descriptive phrases/qualitative, which are subsequently incorporated in the symbolist instructions (fuzzy rules).
\nNeuro‐fuzzy expert system has the following two functions: (i) the generalization of the information derived from the training data processed by the entries with fuzzy learning and incorporation of knowledge in the form of a neuronal fuzzy network; (ii) the extraction of fuzzy rules “IF THEN” using the importance of linguistic relative diversity of each sentence in a prerequisite (“IF” part), using for this purpose a trained neuro‐fuzzy network. The neural network is similar to the standard multilayer network, having in addition, direct connections between the input and output nodes. Activation of nodes is muted, taking the values of +1, 0, or -1.
\nTo work with various fuzzifications in the input and the output layers of the system, it is necessary to interpret the subjective input data. The neuronal network may include groups of fuzzy neurons and groups of non‐fuzzy neurons involving shades and accurate data. The output layer will contain only fuzzy neurons.
\nBy incorporating the factor of certainty (groups of non‐fuzzy neurons) extends the traditional logic in two ways: (i) sets are labeled from the point of view of quality, and the elements in the same set are assigned different degrees of membership; (ii) any action which results from a valid premise will be executed with a weighting in order to reflect the degree of certainty.
\nThe entrances of the system “suffer” three transformations to become exits: (i) fuzzification of the inputs which consists in the calculation of a value to represent the factor of membership in the qualitative groups; (ii) assessing the rules that consists in the elaboration of a set of rules type “IF THEN”; (iii) outputs defuzzification in order to describe the significance of vague actions through the functions of membership and to resolve the conflicts between competing actions which may trigger [10].
\nThe factor of membership is determined by the function of membership, which is defined on the basis of intuition or experience. To implement a fuzzy system, the following data structure is required: (i) the entries in the system; (ii) the functions of the input membership; (iii) the previous values; (iv) a basis for the rules; (v) the weightings of the rules; (vi) the functions of the output membership; and (vii) exits from the system.
\nThe use of fuzzy logic leads to finding answers and allows drawing conclusions on the basis of vague, ambiguous, and inaccurate information. Fuzzy techniques adopt reasoning similar to human, which allows a quick construction of technical, feasible, and robust systems. The application of the fuzzy methods involves less space of memory and a lot of calculation power in comparison with conventional methods. This fact leads to less expensive systems. The fuzzy expert systems should be constructed in such manner that the overall results are able to change in a way that is smooth and continuous, regardless of the type of inputs. Artificial neural networks have the advantage that it can be included in the fuzzy expert systems, becoming parts of it in the framework of a hybrid neuro‐fuzzy expert system. In the majority of the medical applications, the ANN can be used for quick identification of the conditions on the base of FES rules, laying down quickly the rules that should be applied for a given set of conditions.
\nIn conclusion, the specialized literature presents several models of integrating the FES with ANN in the hybrid systems (neuro‐fuzzy expert systems), with medical applications. In the strategy of the human expert (programmer), the ANN is driven to solve a problem, and then, the responses are analyzed in order to extract a set of rules. The integrated systems jointly use the data structures and knowledge. Communication between the two components is carried out with both the symbolic and heuristic information, FES characteristics, and with their ANN structures, that is, using weighted coefficients.
\nTo solve issues related to classification, the objects should be grouped in clusters (in our case patients with speech disorders) based on their characteristics (feature vectors) in predefined classes. Classifiers are then built from examples of correct classification by a supervised learning process as opposed to unsupervised learning, where categories are not predefined.
\nFor the classifier design, based on examples of classification, we grouped data into three main sets:\n
Training data: data used in the training process to determine the classifier parameters (for example, in the case of the artificial neural networks, it is necessary to determine the weights of connections between neurons) (1).
Validation data: data used to analyze the behavior during learning algorithm; the performance on the validation set during the learning process is used to decide whether or not learning should be continued (2);
Test data: used to analyze the performance of a trained classifier (3).
ANN is composed of simple elements operating in parallel. Knowledge of ANN is stored as numerical values that are associated with connections between artificial neurons, named weights. ANN training means changing and/or adjusting the weights values. Most often, ANNs are trained so that for a given input, output returns a value as close to the desired output, a process exemplified in Figures 8 and 9.
\nFor this process, a set of training data (pairs input–output) is required. To solve classification problems, we used the tools package offered by Matlab R2014, specifically the neural network Matlab package (nntool—the tool for classification).
\nWe used a feedforward architecture characterized in [37]:\n
An entry level that has as many units (attributes) as the input data;
One or more hidden levels (the higher the number of hidden units, the greater the complexity of the model extracted from the network; however, this can be a disadvantage leading to decreased network capacity to generalization process);
A level of output with as many units as the number of classes.
There are two main types of artificial neural networks:\n
feedforward—with progressive propagation; the main characteristic of these networks is that a neuron receives signals only from neurons located in previous layer(s).
feedback—with recurrent or regressive propagation; these networks are characterized by the fact that there is a feedback signal from the higher‐order neurons, for those on lower layers or even for themselves.
We used a feedforward network for illustration (see Figure 9).
\nTo design a simple Matlab neural network for classification (“Pattern Recognition”), we used “
a level of hidden units (the number of hidden units can be chosen by the user);
the logistics activation (logsig) for both hidden units and for the output [(output values ranged between (0.1)];
the backpropagation training algorithm based on minimization method of conjugate gradient.
The artificial neural networks have the ability to learn, but the concrete way by which the process is accomplished is dictated by the algorithm used for training. A network is considered trained when application of an input vector leads to a desired output, or very close to it. Training consists of sequential application of various input vectors and adjusting the weights of the network in relation to a predetermined procedure. During this time, weights of the connections gradually converge toward certain values so that each input vector produces the desired output vector. Supervised learning involves the use of an input–output vector pair desired [37].
\nAfter input setting, the output is calculated by comparing the calculated output with the desired output, and then, the difference is used to change the weights in order to minimize the error to an acceptable level. In a backpropagation neural network, learning algorithm has two stages: the training patterns for the input layer and the updated error propagation. The ANN propagates the training pattern layer by layer, until it generates the output pattern. If this is different from the desired target pattern, it will calculate the error and will be backpropagated from the output to the input. The weights are updated simultaneously with error propagation [37].
\nCreate network using Matlab.
Neural network design and training.
The proposed artificial neural network uses supervised learning with two rules (see Figures 10 and 11):\n
extraction of a subset from the training dataset for testing dataset (not used during setting network parameters)
maintaining an acceptable level of error in the training set to avoid over learning (learning insignificant details of examples used for training).
The training process is controlled by means of a technique of cross‐validation, which consists in splitting the initial random set of data in three subsets: for actual training (training); for controlling learning (validation); and for classifier\'s quality assurance (testing).
\nWe used backpropagation as the correction algorithm (regressive propagation of errors) with propagation of the error signal in the opposite direction compared to how the signal travels during the working phase.
\nNetwork training parameters and best validation performance.
Neural network after 1000 iterations.
The training of the neural network lasted 1000 epochs. Matlab interface allows us to display graphs of the statistical parameters, for example, the mean square error, regression (the correlation between desired values and targets, and the values ??obtained; The R correlation close to 1 means a value very close?? to the desired one). Mean values ??for MSE and R are available after training in the main window, under Results section. Identification of classes of subjects from the dataset tested with ANN was achieved with high specificity and accuracy (see Figures 12 and 13).
\nOne of the trivial artificial neural network is SOM—self‐organizing map, which is mainly used for data clustering and feature mapping (see Figures 14 and 15).
\nThe quality of a classifier in terms of correct identification of a class is measured using information from confusion matrix that contains the following:\n
The number of data correctly classified as belonging to the class interests: true positive cases (TP);
The number of data correctly classified as not belonging to the class of interest: true negative cases (TN);
The number of data misclassified as belonging to the class of interest: false positive cases (FP);
The number of data misclassified as not belonging to the class of interest: false negative cases (FN).
Neural network training regression.
Train the network to fit the input and targets.
Neural network training self‐organizing map (SOM) Input Planes, epoch 200.
Neural network training Self‐Organizing Map (SOM) Weight Positions, epoch 200.
Based on these values, we calculated the following measures:\n Sensitivity = TP/(TP + FN) Specificity = TN/(TN + FP) Precision = TP/(TP + FP) Recall = TP/(TP + FN) F = 2 × precision × recall/(precision + recall)
A multilayer perceptron network (MLP) best performance.
The results show that the best performance was obtained using a multilayer perceptron network (MLP). MLP is a feedforward neural network comprising one or more hidden layers. Like any neural network, a network with backpropagation is characterized by the connections between neurons (forming the network architecture), activation of functions used by neurons and learning algorithm that specifies the procedure used to adjust the weights. Usually, a backpropagation neural network is a multilayer network comprising three or four layers fully connected [37].
\nEach neuron computes its output similar to perceptron. Then, input value is sent to the activation function. Unlike perceptron, in a backpropagation neural networks, the neurons have sigmoid‐type activation functions. Derivative function is very easy to calculate and ensure the output range [0, 1]. Each layer of a MLP neural network performs a specific function. The input layer accepts input signals and computational rarely contains neurons that do not process input patterns. Output layer supports output signals (stimuli coming from the hidden layer) and lays it out on the network. Detects hidden layer neurons traits and their weight is hidden patterns of input traits. These characteristics are then used to determine the output layer to the output pattern.
\nThe backpropagation algorithm is a supervised learning algorithm named generalized delta algorithm. This algorithm is based on minimizing the difference between the desired output and actual output by descending gradient method. The gradient tells us how the function varies in different directions. The idea of the algorithm is finding the minimum error function in relation to relative weights of connections. The error is given by the difference between the desired output and the actual output of the network. The most common error function is the mean square error (Figures 16 and 17).
\nRMSE is the mean square error and is used to characterize the scattering of the data in relation to the average. In our case, in all three stages of ANN testing, we obtained RMSE values below 0.5, with 100% identification of classes as shown in Figure 18.
\nPerformance metrics. A multilayer perceptron network (MLP) best classification results (100% for training data vs. 100% for validation data vs. 100% for testing data).
Performance metrics.
In medical applications, it is required to use a neuro‐fuzzy hybrid system that can be fitted with a neural network that presents many advantages such as: flexibility, speed, adaptability. The structure of a hybrid system is represented in Figure 19:
\nHybrid neuro‐fuzzy expert system [
The human expert knowledge is translated as symbolic (1) and is used for ANN initialization (2). The network is trained on a real inputs and outputs system (3). The knowledge obtained using ANN (4) is processed in a fuzzy manner for the determination of fuzzy rule, which are finally communicated to the human expert (5) [37]. These hybrid systems are suitable for the acquisition of knowledge and learning, and they can achieve inclusive process using weighting of the fuzzy neural network connections. Using a simple learning algorithm, such as backpropagation, neuro‐fuzzy hybrid systems can identify fuzzy rules and then learn the associated functions of inferences. In summary, the hybrid system can also learn linguistic rules (fuzzy) as well as optimizing existing rules.
\nDuring generation and validation of expert system rules, we observed a positive correlation between speech disorders and eating disorders (obesity), so that a higher Body Max Index (BMI) exacerbated learning and speech difficulties in children. This is consistent with previous work demonstrating that risk of being obese in young adulthood was increased if the child had learning difficulties, scholastic proficiency below the class average, received special education, or had scholarly difficulties in childhood [38]. Therefore, our future studies will address the causal relationship between overweight, obesity, and various functions related to speech disorders and learning abilities during a longer period of time.
\nEach decision technique has specific advantages and drawbacks when it is used in medical field. Thus, a FES is able to make inferences with approximate data and, more importantly, it can track the decision‐making process (i.e., the chain of activated rules). However, the rules must be written and, eventually, modified by human expert only. On the other hand, the artificial neural networks are the best choice when dealing with a large quantity of data and wish to obtain the related pattern but unable to provide useful information on how a specific conclusion is reached.
\nDue to the complementarity of expert system and artificial neural networks, several attempts to integrate these techniques have emerged. For example, combining qualitative modeling (based on fuzzy if‐then rules) with quantitative modelling (used when all we have is chunks of already classified data) represents a major step forward. The hybrid neuro‐fuzzy expert system is able to both learn by examples and organize knowledge and meta‐knowledge in the form of fuzzy rules. For this type of system, we first fuel neural network with symbolic information and then adapt the raw model using individual examples. At the end of the process, we are able to extract symbolic information from trained neural network.
\nTo the best of our knowledge, there are few, if any, studies based on the utilization of above‐mentioned hybrid techniques in speech and language therapy of children. In this chapter, we have proposed and validated this original approach using Logomon, the first CBST for Romanian language. We have demonstrated that it is possible to use the equivalent relation between a fuzzy expert system and an artificial neural network in order to capitalize on the advantages of both techniques. The results are very encouraging and provide strong impetus to continue these studies by extending rules database and by optimizing integration between the two parts of inferential system.
\nThese authors contributed equally to this book chapter, and the work was supported by the Romanian National Program PN‐II‐ID‐PCE‐2012–4‐0608 no. 48/02.09.2013, “Analysis of novel risk factors influencing control of food intake and regulation of body weight”.
\nCOVID-19 pandemic has changed the world. More than half of the planet’s population, namely, more than five billion people have been isolated during the last year, changing regular life, habits and thoughts. Most international flights, travels, events and gatherings, sports and cultural programs including World Expo, World Sport Cups, and the Olympic Games have been cancelled, political and scientific events moved to the online format. The global economy has collapsed and prognosis for the next year includes the increase in hunger and poverty. International organisations, national and international leaders could not shade their own weaknesses and disorientation. Wrong decisions, non-justified actions and declarations were made… Being medico-legal expert who used to look into facts rather than rumoured and unproven information, the mortality rate is the first thing that is taken into consideration. According to our analysis of mortality rates in different continents and countries that have been made from the beginning of pandemic we have seen that panic in the countries, frightening messages from TV screens, media speculations in newspapers have been developing in a similar scenario to aggravate dangers of the pandemic, which is probably more beneficial for certain political reasons rather than economic, scientific, medical or public. Our definite conclusion is that this pandemic is not only medical and biological problem. From other side, our observations shown it may have great value for the world if to take right lessons from its global effects on our future lives.
Thus, the article provides a qualitative analysis of the factors associated with the pandemic in the field of biotechnology and other spheres of life through their reflection in the media.
Despite its negative impact, the pandemic primarily gave impetus to the development of biotechnology that ensured creation of effective tools to combat the coronavirus. Biotechnology, in addition to traditional fields such as genetics or molecular biology, is also based on information technology. Computer modelling tools provide wide opportunities for modern biotechnologies. Those tools ensure faster study of viruses, identification of their genome and, as a consequence, development of new testing methods and disease prevention. The innovative biotechnology tools accelerated study of sequence of the new coronavirus genome. As a result of their application in just a few weeks after discovery of the disease [1, 2], its virus genome has been analysed.
Prompt decoding and computer modelling of the virus created conditions for development of express coronavirus tests [3]. Moreover, biotechnologies ensured the development of various types of vaccines against the virus [4] based on different methods. In that context, biotech companies have become a kind of founders in the hope of fighting against the pandemic as they are at the forefront of research to develop vaccines and treatments.
It is the development of modern biotechnology that has led to such a rapid development of various vaccines in such a short time. Considering urgency of the situation U.S. Food and Drug Administration (FDA) has authorised several vaccines for emergency use. Thus, based on clinical research results as of March 2, 2021 CDC information confirms [5, 6, 7] the efficacy of the approved vaccines as shown in Figure 1.
Efficacy of the CDC approved vaccines. Data of 2 March 2021.
Although vaccines are the most important tool developed because of the application of biotechnology in the fight against coronavirus, their effectiveness at the initial stage caused a heated discussion in the media. Moreover, their use and side effects have become the subject of massive misinformation and rumours among population. In order to avoid similar phenomena in the future and to help biotechnological companies and states to correctly develop their strategy for working with the media, we consider it necessary to analyse information and most common media cases related to the pandemic in this context.
Today, computer technology has become an integral part or even a fundamental tool for scientific research, especially in high-tech research such as biotechnology. However, development of information technology is inherently associated with the Internet and media in general. Scientists and biotechnology companies analyse media resources in order to study the social aspects of people’s lives and conduct relevant research. Moreover, media resources such as social networks create opportunities not only for the communication of scientists, but also for identifying trends in public discussions and sharing their research or developments. Thus, the Biotech-careers web-resource conducted an analysis in their database and found 109 companies in 364 localities working on COVID-19 as of April 06, 2020 [8]. We presume that those numbers are increasing. During the pandemic, reports on biotechnology found wide media coverage but what did the pandemic represent for society?
The COVID-19 pandemic has become one of the largest threats facing humanity. However, can we say that it was the disease, fight against which was worth such unprecedented measures as complete lockdowns, the cancellation of all public events, depriving people of such a basic right as freedom of movement? What became the hallmark of the disease besides the fact that it was a new strain of the coronavirus infection?
The humanity has already faced epidemics and pandemics earlier. The diseases such as tuberculosis, smallpox, the virus called “Spanish flu” killed thousands of people. In our opinion, in addition to purely medical and epidemiological factors, the key factor that distinguishes COVID-19 is the role of the media. In contrast with the 19th or early 20th centuries when there was no Internet, social media, so many TV and radio companies, today the number of such sources of information is innumerable. The era when people had to wait for a new issue of the newspaper to get information is outdated. Today, thanks to media resources and the Internet, information is updated every second. The presence of social networks contributes to the prompt dissemination of the information. However, it is often distorted or even “overgrown with rumours” on the Internet.
Various viruses coexist with humanity. For example, although the influenza virus is activated every year, lockdowns and other global restrictions are not enforced. Successful fight against seasonal flu is a prime example of biotech progress. Experts have learned how to cope with the influenza virus [9], which infects thousands of people every year. However, modern biotechnologies allow not only to cure people from influenza, but also to prevent its spread.
Because of enforcement of the measures to combat COVID-19, all areas of life were paralysed. Even biotech companies faced difficulties in their research due to lockdowns and morbidity risk among staff.
Closing the borders of states, stopping civil interstate flights and other measures led to many social and economic problems. Thus, the Azerbaijan citizens who used to travel abroad for the medical tourism purposes had to postpone planned procedures because of the closure of borders and the suspension of air traffic for some time. Although restrictions on air traffic had a positive effect on the environment, it is difficult to assess the balance of harm and benefit when comparing the social activities, economy and the environment. Restrictions and associated social, economic problems, depression and increased anxiety in society, the violation of all social contacts, when people were afraid or prohibited from meeting with relatives and friends, were weighed against the risk of spread of the disease. Therefore, it is difficult to assess the benefit of restrictive measures as both economic and medical areas play the key role in life of the world community. However, there were also exceptions. The Republic of Belarus has not implemented the restrictive measures and, nevertheless, the mortality rate in the state was “one of the lowest in the world” [10]. If in Azerbaijan throughout all the investigated period of the last 11 months mortality rate was not above 1,5%, in Belarus this was less than 0,7%. If today in Azerbaijan we have about quarter of million contaminated during last year COVID patients, Belarus had slightly more for a few dozen thousands people, but mortality was twice less. Moreover, this is in a situation, when they did not close schools, universities, stadiums, public transport, nothing. They made a military parade of Victory Day 9 May 2020, presidential elections, had millions on the meetings and demonstrations after but COVID did not appear as frightening as in the rest of the world. Belarus and Azerbaijan both have similar geography and population about 10 million but management of pandemics were very different, and they succeeded even more than Azerbaijan and the rest of the world. In one of our past articles, we mentioned that the main reason was that the genotype of neither Azerbaijani nor Belarus was a target for COVID-19.
Talking about social and other factors, we return to the role of the media. What was their role and remains today? At first glance, the media simply broadcast the latest summaries of information about the disease and its mortality. The provision of statistical information, which often did not represent any value for the average reader, caused panic and fear. Therefore, it often had more negative than positive significance. Obviously, in pursuit of the rating, the media often published data on the most rare consequences and symptoms of the coronavirus infection [11, 12]. Although the experts later explained the reason for the incident, rumours continued to spread, especially on social networks and telephone voice messengers. The example of such misleading information is the change in skin colour from the coronavirus. Publication and replication of such incomplete information to attract visitors is an example of the so-called “hype” [13]. People reading such headings and sometimes without even opening the whole article begin to panic and spread this information.
Information resources on various platforms both at the beginning of the emergence of a new virus and today are full of headlines that “the world will no longer be the same” [14]. Many new terms have appeared during the pandemic. They either did not exist before or were not widely used. Terms such as “fake news”, “lockdown”, “covidiot”, “doom scrolling”, etc. entered our daily life. Another example of such terms is “infodemic” [15]. In our opinion, this word most clearly shows how large-scale the flow of information associated with the new virus has become. This term, highlighted by the WHO, described the unfounded information, which does not reflect the truth. It includes panic news and in some cases concealment of the essence of the information, rumours, and conspiracy theories aimed only at misleading the society. Human beings tend to believe and share alarm warnings. Such information in addition attracts more readers, which is of higher importance for the media resources. That became a key factor of the development of infodemic.
Often, the official media unintentionally sowed panic among the population, reporting on the upcoming lockdown, disinfection, etc. Thus, such panic gripped the society in Baku, as in other cities of the world, during the announcement of the complete lockdown [16]. People rushed to the markets buying almost everything after hearing such news [17]. Although full lockdowns in Baku lasted no more than two days, people bought several times more bread than usual. Society affected by the impact of the panic experienced as a result of the unexpected announcement of the news about the restriction exaggerated by rumours that flooded social networks and voice messengers have only fuelled peoples’ fears. On the contrary, along with panic and socio-economic tensions, so-called memes or funny pictures about the coronavirus [18] were also spreading on the Internet. Of course, this does not mean that we should not take the virus seriously. All medical advice must be followed, but one must not be afraid. In addition, even if in social isolation, we should do it without fear. We should strictly follow personal hygiene and distancing but not fear.
A lot of information, which was often fake, had a detrimental effect on both the psychological health of people and hindered an effective fight against the pandemic. People, left in complete isolation, were forced to search for information on the Internet in order to understand what was happening, how to protect themselves from the virus. Given the high interest in the subject matter, the unscrupulous media, accordingly, published and updated information, which did not always reflect reliable data, at lightning speed. Regular users who did not have in-depth knowledge of the topic and were unable to distinguish scientific data from rumours started to panic at such fake information. People prone to depression, who are in chronic stress, suspecting they have a coronavirus, lost their ability to adequately assess the situation. A large number of news, often-fake ones, about the coronavirus, and their even greater spread on social networks, indicate that the criticality of information perception in times of turmoil decreases sharply. This is what the mass distribution of infodemic is based on.
Cybercriminals on the Internet have also contributed to the increase in the scale of the infodemic. Thus, they created hundreds of so-called bad bots [19]. These programs, imitating the behaviour of a real person, spread deliberately false and misleading information. However, during the pandemic, positive bots created by official structures served to provide help. Thus, a bot launched in Azerbaijan [20] allowed people to check themselves for the signs of the coronavirus infection.
However, is it right to say that the pandemic was accompanied only by false news? It is not only the information itself that is very important, but the context in which it is presented and its emotional colouring. Thus, national media in all countries of the world, as well as global media, began to publish “shocking” data on death toll from the coronavirus. Media headlines were mostly representing data on negative facts about the coronavirus. In this context, wasn’t it a manipulation of readers aimed only at increasing the “clickability” of the title? It is obvious that the worse the news about the disease, the more readers it will attract. Haven’t people before that die of AIDS, cardiovascular diseases and other diseases? How important is the context of presenting information? Infodemic, when information or misinformation spreads virally, like the spread of the viral infection itself, has become the result of the work of the media and social networks. Pure statistics, even if it concerns mortality, can be frightening or neutral depending on different contexts [21]. 3000+ deaths from COVID-19 in Azerbaijan during 12 months repeated everyday from TV channels impact deleteriously to the mental health of the people and make them panic. This is natural for public to be afraid. However, as forensic experts in Azerbaijan we know that the average mortality of the country about 60 thousands deaths in the past year makes three thousands less than even 10% of mortality. Is this a justified reason for things we observed in last year? We do not think so. Majority of people continue to die from traditional diseases and most of dying COVID patients are also dying from own main diseases aggravated by concomitant coronavirus infections, which was always happened in past when influenza made complications for such categories of diabetic, cardiac, oncology, hepatic and renal patients.
Literally recently, from a historical point of view, humanity has been fighting epidemics such as “SARS (2002, 10% of deaths from those infected), avian flu (2003, 50% of deaths from those infected), MERS (2012, 35% of deaths from those infected), Ebola (2014, 40% of deaths from those infected)” [22]. At those times, the media was also filled with information of a frightening nature. However, humanity coped and literally until 2020, people lived a normal life, and only virologists and epidemiologists spoke about viruses in everyday life, to a lesser extent - representatives of other medical specialties.
Aimed at creation of sensation impressions and mass distribution, and in the case of social networks to get more shares, likes, views, journalists and bloggers, ordinary users, knowing nothing about medicine, or knowing at the level of the non-professional, write about the pandemic, the virus and even give treatment advices. How ethical in that context is writing of news by a person who does not have professional education in this area? What shall be the criteria? What medical, epidemiology and other information can and cannot be published by a non-professional? We usually do not look into the education of the author of news but is it important in the era of pandemics? There are no definite answers, since everyone is entitled to the right to have personal point of view. From a legal standpoint, freedom of thought and expression of will is an inalienable human right. However, if a person disseminates knowingly false information, gives advice of medical nature without a licence, then personal opinion becomes an example of violation of the law. If the advice caused harm to health, then this action entails criminal liability. At the same time, we know many examples of medical errors done by professionals [23]. Therefore, it is impossible to mark the availability of medical education as the standard for authors writing or speaking about the pandemic. We can conclude that the coronavirus pandemic has led not only to medical but also to many ethical and legal issues in society as well.
If earlier the society experienced a lack of information, now there is a surplus of it. A person is simply not able to assess the scale of the incoming information. Thus, the query “coronavirus” in the popular search engine Google as of mid-February 2021 gives out about 2.220 million [24] search results. Publication of such a large amount of information is often accompanied by a decrease in its quality. Unfortunately, in this case we have to rely on the search engine and hope that it will show the most truthful, complete and interesting information in response to our request. Most people in a fast-paced world have neither the time nor the energy to browse through a large amount of resources. In the old days, people went to libraries, where there was a large, but limited number of sources. Today, their number on the Internet is simply physically incalculable.
In times when only government agencies were the sources of information, it was possible to trace its author and purpose for which the publication was made. It is clear that at all times the media are always engaged to some degree. It is difficult to say, in our opinion that the media is independent when they have sponsors thanks to which they actually exist. However, there are state and large private media holdings committed to publishing clear information in order to maintain their status as a reliable source. In addition, even in the event of an error, they tend to publish an immediate rebuttal. Nevertheless, even they can hardly be called completely independent. Rating and audience coverage are also important for them.
In the context of the coronavirus, many types of media, both private and public, have sought to convey information as quickly as possible. However, if the “prestigious” resources that treasure their name gave out only official information, then the rest of the media, guided only by attracting the audience, often published an outright fake. Often, the media, referring to famous doctors on their behalf, published information that did not belong to the author at all. What the author indicated either as possible or researched was published as accurate information.
Spreading of false information (or so-called “fake news”) has also become a serious problem. Such news are distinguished by their manipulative nature [25]. Often the authors of publications publish them not by mistake but purposefully. To attract the attention of the population media especially online publications for which traffic is especially important, often referred to the unconfirmed or even false information contributing to its spread. Misleading information can be related to both the disease itself and the methods of its treatment. Thus, information about folk remedies and methods of disease treatment, with the protocols for the use of alternative medicine, which often only worsened the patient’s condition, has filled the Internet.
Lack of medical knowledge and panic among politicians contributed to the dissemination of such information by the media at the initial stage of the emergence of a new virus.
Often, even before the confirmation of the effectiveness of the drug or treatment method and protocol, the media began to spread information about it. Thus, at the initial stage of the pandemic, there were reports of the possible efficacy of certain drugs such as antimalarial one. Media resources began to replicate information about this medicine; even some famous personalities claimed its effectiveness [26], which further increased the public interest. Based on unproven information, some people began to use this drug without a prescription, which led to serious side effects, and in some cases even death [27]. Only after clinical trials, scientists and medical professionals concluded that the drug is not only ineffective but can be even dangerous for use by certain parts of the population [28]. Nevertheless, unfortunately, despite further denial in the media, there was already data on mortality caused by the use of the unverified information. However, at the initial stage, in early 2020, COVID-19 was a new type of disease for the medical and scientific community. This significantly complicated the work of doctors and less of the media. In the beginning, when there were no approved and proven effective treatment protocols, doctors had to verify any information empirically, that is, to use all available treatment options to save lives. However, the media, in pursuit of the rating, immediately publishing these data, albeit even if unintentionally, misled people.
Since the appearance of a new type of virus, many theories about its origin began to appear on the Internet. At an early stage, various rumours that have spread on the Internet, in the absence of scientifically proven facts caused distrust among people [29]. This fact largely contributed to the emergence of conspiracy theories. The so-called conspiracy theories put forward different ideas massively replicated in the media. In addition, even when experts denied the causes stated as the reason for the emergence of the virus in theory or the resources themselves published a refutation, people continued to spread information through social media networks. The most popular was the theory of the spread of the virus by the communication stations, which led to dozens of cases of the destruction of stations by the population [30]. Spreading of such misleading information forced internet resources such as popular social media [31] to mark the information about the coronavirus as unverified and in some cases to even delete or block it.
In response to mass disinformation the WHO as well as UNESCO, European Commission and other organisations have created special web platform such as “mythbusters” to in an understandable form with the help of specialists to debunk each of the myths and provide scientifically based information [32, 33, 34].
We think reality we have now and experience we gained in last year could make us taking very positive lessons as well: decrease of mortality started in the second half of the last year and continued to present levels even in pre-vaccine era, 80% of contaminated population had mild course of disease, more than 90% of population has recovered, young people and children were ill much rare than the older age groups, panic took more people to the death rather the disease itself.
Since the very appearance of vaccines in the media, unverified and often false information about vaccines began to spread. As well as it was with the coronavirus itself. The most widespread conspiracy theory, of course, was the “chipping”. This fake appeared at the beginning of the pandemic and explained its appearance as the desire of certain forces to microchip all of humanity by means of vaccination.
The efficacy and safety of vaccines has been the subject of debates. Although vaccines appeared just a couple of months ago, the media were already filled with information about mortality after their introduction [35]. Unfortunately, mortality from the vaccine as a reaction of the body (anaphylactic shock) is quite possible, even in the case of the administration of long-used, well-studied vaccines.
COVID-19 vaccine has recently appeared. Due to its urgency, it has not passed long-term clinical trials, which usually take 2–3 years. However, preliminary data made it possible to speak about their effectiveness and safety, which gave the WHO reason to approve the first yet vaccine.
The media circulating conspiracy theories and other fakes earlier are now publishing news about the need for vaccination. An interesting fact is that even now the Internet is filled with information about vaccines’ side effects, which alternates with a call for vaccination. The media, with their fast-changing and sometimes diametrically opposed news, is often misleading their viewers and readers. Many people, reading about mortality from coronavirus, want to be vaccinated immediately, while others, reading about its side effects, start to panic.
Publishing only information on side effects and mortality from vaccinations, the media rarely covers how many people were successfully vaccinated. How many and at what level developed antibodies after? That is, one gets the impression that the media are not engaged in providing information, but in only attracting an audience or so-called hype.
It is also necessary to note the inadmissibility of discrimination against people who refuse vaccination. Coercion violates a constitutional human right and right for autonomy and dignity. Moreover, for some people, vaccination is contraindicated due to the medical reasons, such as allergies to its components. However, media are actively broadcasting information about “covid passports”, manipulating peoples’ fears.
Azerbaijan is the first country in the South Caucasus region and is one of the first in the world that ensured vaccines’ delivery and has launched vaccination on 18th of January 2021. Vaccination is implemented free of charge for the citizens and on voluntary basis thus protecting the autonomy of decision-making.
The Cabinet of Ministers approved the “Strategy of vaccination against COVID-19 in the Republic of Azerbaijan for 2021-2022” on 16 January 2021 by the Order No. 48 s. The phased vaccination strategy implemented in the country prioritises the elderly and medical workers.
The vaccines approved so far by the CDC are not yet available in Azerbaijan due to the lack of sufficient amount of them at the manufactures and high demand. However, the country has contributed $21 million [36] to the COVAX [37] initiative and supports all international activities in the fight against the coronavirus [38]. Moreover, as the delivery of vaccines within the COVAX is still expected [39], Azerbaijan has already purchased 4 million vaccines of Coronavac from China [40] to start the vaccination early. The procedure takes time because it includes an examination of those wishing to be vaccinated. For check-up and vaccination purpose, the State Agency for Compulsory Medical Insurance has launched a new electronic service called “COVID-19 vaccine appointment” [41]. Vaccinated citizens will be issued an electronic certificate in case of need a vaccination document when travelling abroad.
Today, in addition to official state and private information companies, social networks have become a great source of information. Conceived to create a means of convenient communication and exchange of information between people, social networks have become independent sources of information. Although most of the official media, government officials and various international and other structures have official pages in the networks, in addition to them, there are millions of other pages. Some pretend to be original, creating fake profiles on behalf of the official or structure. Others share information at the rumour level, creating a false impression of credible awareness.
Smartphone messengers posed a special threat in this sense specifically when messages were sent from person to person, and the author could only be identified by involving law enforcement agencies. Thus, one of the most “egregious” fakes, widespread in Azerbaijan, was a voice message about the alleged disinfection of the entire country from a helicopter [42]. Unfortunately, doctors themselves often participated in the spread of such fakes, as they later explained “under the influence of panic” [43] or, more horribly, for the sake of joke [44].
During the pandemic, Azerbaijan had to introduce fines, administrative or criminal liability for spreading rumours about the coronavirus [45]. Of course, doctors, like the rest of the population were in fear and stress during the peak period of the pandemic in the country and in even more risk of being in constant contact with patients. However, the role of the media, especially unofficial ones that disseminated such information should not be underestimated. In the case of instant messengers, the situation is even more complicated for a number of reasons. First, they guarantee the confidentiality of the information sent through their platform. Secondly, personal correspondence is not an official source of information and only expresses the opinion of the author, to which everyone is entitled by law. Moreover, since the information is private it does not imply distribution. However, unfortunately, the pandemic has shown that information can be disseminated through instant messengers even faster and on a larger scale than through publications on the Internet. For example, some messengers had to mark frequently sent messages as a possible fake or even prohibit their forwarding [46]. However, these restrictions are sometimes ineffective. The user can not only simply forward the message to others, but also write a new one, referring to initial information as “heard” one, “it was said that…”. As a result, the original message is further distorted and overgrown with rumours. There is no responsibility of messengers in this context. It is impossible, since they do not break the law by their work. They only do what they were created for, namely they represent the means of communication.
People who use social media or phone messengers should understand their responsibility by sending comic messages on such a serious topic as the coronavirus. In addition, it is the personal responsibility to trust rumours or not. The only possibility to protect our safety in this regard is to verify all the incoming information with the official sources, such as the state ministries’ websites and think critically about the news we get.
Along with high uncertainty and anxiety, the pandemic has created conditions for development in some areas. As a result of total lockdown the digitalization of society has accelerated. People were forced to spend more time on the Internet. Many workers were transferred to the so-called remote job. Online shopping began to develop in those countries where it was not popular before. Even areas that previously seemed impossible online have begun to adapt to the new environment. Thus, online pharmacies began to appear in Azerbaijan, school and university studies also switched to online training, and special training platforms were launched. Telemedicine has started to be developing.
Online commerce and marketing are the areas that have benefited most from the coronavirus-related restrictions. Clothing manufacturers often used the coronavirus theme. Advertisements for T-shirts with various inscriptions and images on the topic of coronavirus appeared on the Internet. Some companies have supported healthcare [47] by producing medical equipment, which was also a good marketing strategy.
Although internet commerce has grown rapidly due to the pandemic, it is difficult to say that it will permanently eliminate shopping malls, at least not in the next decades. Hiking to the malls often has nothing to do with shopping. People, especially the youth, went to shopping malls, which usually have restaurants, cinemas, and a lot of entertainment such as bowling, to spend their leisure time and meet with friends.
The field of telemedicine is perhaps one of the few that has evolved during the pandemic. Today it is still too early to talk about general surgical interventions that can be performed remotely via the Internet (although such experiments have been implemented already [48]). However, telemedicine in today’s conditions has become a real salvation for both patients and doctors. First, patients could save the time they usually spend travelling to the hospital. Secondly, the doctor and the patient were both protected from possible infection, since often people themselves did not even suspect that they were infected (the so-called “asymptomatic patients”). In addition, in some cases, the patient does not need a real examination, but a consultation, an adjustment of the treatment course. The psychological effect is also important when the patient turns to the doctor “to calm down his fears”. In the case of the field of psychology, telemedicine was easily possible, and it did not lose its meaning either. Since in psychological practice the factor of communication prevails and does not require physical contact such as, for example, in the case of traumatology.
The coronavirus pandemic is a unique phenomenon. Right after the emergence of the virus and information from China, people around the world were locked-up in their homes. Cities and streets became empty. The world community divided into groups of those who feared the new virus and those who did not believe in it. Fear changed the world. Politicians had to enforce restrictive measures to create a sense of security among citizens. Moreover, the population blamed politicians who did not act. However, there was also another part of the population that was left without income because of restrictive measures, whose business went bankrupt. On the contrary, they wanted the restrictions to be lifted as soon as possible. Many people came out to mass demonstrations against the mask regime and other restrictions in such big cities such as London, Berlin, Madrid, Amsterdam [49, 50, 51, 52].
Comparative statistics analysis for 9 months (March 2020 – February 2021) shows more than two fold growth in morbidity and mortality in the world. Coronavirus cases at the end of February 2021 almost doubled compared to May 2020 (about 112 million compared to more than 5 million) [53]. The coronavirus death toll also increased significantly. Thus, for the mentioned period it has increased from 351,886 in May 2020 to more than 2 million 400 thousand deaths to date. However, recovery rate also has increased indicating that more than 87 million or about 80 percent of patients have already recovered [54]. The above data give us reason to believe that most of the people currently undergoing treatment will fully recover. 99,6% of those who are active cases now have a high chance to be recovered. So, our observations of global mortality rate being 6–7% in early months of March – April, went down to 5–5,5% in May – June, then to 4% in August and to 2,2% from the fall of the year till start of the vaccination. This says a lot. So present mortality rate at 2,2% is not a result of vaccination but this is result of natural processes, which can be scientifically explained or not, but this is a fact which all of us should accept.
The disease, which was classified as the pandemic by the WHO, which affected more than 100 million people in one year has been also registered in Azerbaijan. At the beginning of January 2020, when there were no cases of infection among the population, epidemiological and overall situation in Azerbaijan was not so tense. Even before the first officially documented coronavirus case, the authorities have started the development of the antiviral measures. These measures included the adoption of the Action Plan to prevent the spread of the new coronavirus disease in the Azerbaijan Republic, and then the creation of the Task Force under the Cabinet of Ministers (Task Force or Operative Headquarter under Prime-Minister) to combat coronavirus [55]. However, the escalation of the situation in the media made the situation worse. Global and local media resources covered information of a purely medical or biological nature. This information was not familiar for the average reader, but aggravated fear in society.
The first case of the coronavirus infection was registered at the end of February 2020 in Azerbaijan [56]. The shocking news from other countries by that time have already scared people. Subsequently, after the first death case that followed in March [57] social situation deteriorated. The massive information flow, which was accompanied by frightening statistics about the rapid spread of the virus and lack of treatment of the unknown disease filled local media. The further introduction of quarantine measures led not only to the deterioration in the emotional state of people, but also disrupted the work of almost all areas.
Throughout the year, easing and tightening of the quarantine regime have changed alternately several times, that had a negative impact on the psyche of the people and the economy of Azerbaijan. Thus, according to the latest data, the state spent 2 billion manats (local currency, 1 USD = 1,7 AZN manat) to fight the coronavirus in the country in 2020 [58]. The imminent recession in the economy, business activity, tourism and other spheres negatively affected the economic condition of people. As a result, the income of the population has significantly decreased or stopped altogether. Although the state has provided financial support [59] to the citizens and entrepreneurs [60], people accustomed to the certain level of incomes, who took out a flat or a bank loan on a mortgage, found themselves in very difficult circumstances. The most difficult situation was observed in the tourism, restaurant, and entertainment sectors. Under the conditions of quarantine measures, their work was either prohibited or significantly restricted. Consequently, the economic factor has become an additional reason for the deterioration of the psychological health of the population. Moreover, under the conditions of the strict quarantine, restrictions and even ban to leave home were applied in the country [61].
Implemented during the quarantine time limit for leaving home [62] negatively affected people’s everyday life. In fact, people were limited to outdoor walks. The time restrictions on leaving the house forced people to make a choice between visiting, for example, a bank and taking a walk in the park or even doctor visit.
The ban on the work of gyms and admission to parks has become an additional fact of the aggravation of not only the physical but also the psychological health of the people. Accustomed to a sports lifestyle were limited even to visiting parks and the sea. Morning jogging along the embankment was allowed only in compliance with epidemiological measures, such as wearing a medical mask, which questioned the benefits of such a run. In our opinion, in Azerbaijan, where the summer season is very hot wearing a medical mask during that times was more harmful than beneficial especially while morning jogging. Wearing a mask limited calm breathing, caused shortness of breath and additional sweating. In general, from a medical point of view, the value of wearing a mask in the hot summer season, weighed down by the high levels of humidity that is observed in the most parts of the country, from our point of view, are not just controversial, but rather negative. Thus, sweaty masks, in conditions of poor air exchange during summer season, often absent or very weak wind attracts bacteria more than protects health. Such measures had an extremely negative impact on both the physical and emotional state of people. Moreover, unfortunately, masks were not distributed free of charge on a massive scale to the country’s whole population. Therefore, some people ignored the need to change the mask every 2 hours, and there was no point in it due to the high air temperature, which some days was above 40 degrees Celsius, and high humidity.
Even during the hot summer months, within the framework of quarantine measures people were deprived of the opportunity to visit the beaches. Access to the beaches was opened only at the beginning of August when the beach season in Baku was already ending [63]. Moreover, the opening also took place subject to the necessary epidemiological measures [64] such as social distance between beach loungers and limiting the number of people on the beach. To this end, a website was created where people could book their place in advance on the beach and estimate how many people are there.
Places of religious worship were also closed in Azerbaijan during the tough quarantine as well as in many countries. However, people who were already in the stressful state and used to find peace only in such places through prayer were deprived of this opportunity. The pilgrims were deprived of the opportunity to perform the Hajj [65], the devout deprived of carrying out religious rites in relation to those who died from the coronavirus. The closure of churches [66], temples, mosques and other places of worship at certain times has been implemented around the world. Unfortunately, it is difficult to maintain social distance in places of worship. There were also recorded cases of mass infection in such places [67, 68] that ensured the restrictive measures. Nevertheless, such restrictive measures have created an additional burden on the psychological health of people and have disrupted the usual way of life. The mosques remain closed even at present. Moreover, the closure of the religious sites while restaurants are open is also causing debates in the society.
We believe that one of the unjustified measures taken in the fight against coronavirus in Azerbaijan as well as in many other countries was the disinfection of the streets. The chemicals used for the disinfection were further absorbed into the soil, disrupting the ecology and harming biodiversity. Moreover, these substances posed a particular threat on people’s health, especially of those suffering from allergies and lung diseases. Therefore, both from an environmental and a medical point of view, this measure caused more damage than benefit. Large financial resources were allocated for its implementation, which in the conditions of the economic downturn was spending that could be directed to health care needs. An additional, albeit not so important, negative factor of disinfection is the inconvenience of the population. Often people were advised not to leave the house during disinfection.
From the epidemiological point of view, mentioned restrictive measures might be justified if they made sense in terms of reducing the rate of increase in the incidence. However, the statistics, unfortunately, show the opposite. Moreover, the negative influence of the lack of sports activity and walking in the fresh air, the importance of vitamin D produced by the body under the influence of sunlight is widely known. That is, the restriction on walking in the fresh air led to stress and an even greater weakening of natural immunity, which is so important in the fight against the virus.
Restrictive measures in connection with the coronavirus in Azerbaijan have been further tightened as a result of the introduction of martial law at the end of 2020. Coronavirus disease during the war has become an additional burden on the healthcare system. The outbreak of the Patriotic War or the Second Karabakh 44-day war [69] at the end of September created tension in society. News reports from the front line were combined with statistics on the spread of coronavirus infection. Moreover, the restrictive measures have been further tightened in connection with the introduction of martial law in the country. The country’s health care had to solve a difficult task of allocation of resources between the needs of the front and coronavirus hospitals. In this respect, this period was especially difficult for doctors. Consequently, the health care system was overloaded during this period.
The Task Force significantly weakened the quarantine regime, however, has not completely lifted it as of February 2021. Thus, a number of restrictions such as the necessity to wear medical masks, large shopping centres and metro remain closed, public transport does not work on the weekends, will remain valid until April 2021 [70].
The coronavirus emergence also gave impetus to the development of domestic healthcare in Azerbaijan. Thus, foreign experts from China, Russia, Italy and Cuba were repeatedly invited to the country to exchange experience and help to fight coronavirus [71, 72, 73, 74]. For the first time in the country, modular hospitals were opened [75]. Factories for the production of medical masks and even disinfection tunnels [76] for domestic use and export have been launched.
As of February 2021, statistics on coronavirus in Azerbaijan show about 80 percent recovery [77]. At present, some patients are still in hospitals, some are being treated at home, so it is difficult to give a final figure yet. However, based on one-year observation we can assume that the final death rate from the disease in the country will be low and not more than 2 percent.
Not only Azerbaijan experienced coronavirus-related restrictions. Worldwide unprecedented control measures have been taken. Thus, all international sporting, cultural and scientific events have been cancelled. Many events such as international chess tournaments and even political meetings with the participation of state officials were held in the online format.
Restrictive measures of unprecedented scale and often-conflicting media coverage may have resulted from the lack of timely action by the WHO [78], which declared pandemic and gave appropriate medical advice to the member-states quite late. Were these measures justified? Experts have yet to figure it out. At the initial stage, when the world was gripped by panic due to the unknown type of virus, such measures may have been necessary. However, by the middle of 2020, their destructive side in relation to the economy and the psychological health of people became clear. A similar situation and restrictive measures were observed in many countries of the world and for now, people still do not have the opportunity to return to their usual way of life. For now, continuation of quarantines around the world, restrictive measures when the coronavirus infection has already been studied and vaccines have been developed and made available, is questionable and causes controversial ideas among the world community.
Despite all the restrictive measures taken in the world, the pandemic did not stop, and only a year after its emergence the European Commissioner admitted that “the borders do not prevent the coronavirus” [79]. Unfortunately, society has gone through practically a halt in all social life. It has been deprived of the opportunity to visit other states for more than a year. However, today there is no decision to completely lift restrictions by all states. Some countries announce quarantines even in 2021 [80]. The Internet today is filled with “predictions” about how the world has changed, that it will no longer be the same again after COVID-19. Positive ideas are replaced by negative ones and vice versa. All this information affects the psychological state of readers. For some, coronavirus is depressing, for the others it has opened up new opportunities and ideas. “What will the world be like after…?” Journalists and representatives of other spheres argue. A little over a year has passed since the emergence of the new virus. What can we conclude for today? First, the impulse that the virus gave to the development of biotechnologies and medicine. In just a year, several effective vaccines for coronavirus appeared at once in particular thanks to the development of biotechnology. Have we encountered such lightning-fast vaccine development before? Perhaps, the developments scientists have launched today will give positive results for medicine in the future. Despite all the seeming global changes, if we remove the noise created in the media, then nothing has essentially changed. At each stage of human development, one can note the events that “changed” life. Thus, “Spanish flu” has led to the death of millions of people. At that time, it seemed that society would not return to normal life. Nevertheless, humanity coped with the disease and continued its development.
However, we consider the role of the media to be the most important aspect of the pandemic. Media resources are the most important source of information. We have witnessed how misrepresentation of information or its deliberate distortion can harm society, how it affects psychological health. Nor should the role of the state be underestimated in this regard. Politicians, heads of states are interested in the development of society, elimination of threats and maintenance of public health. However, inappropriate or unnecessarily strict measures can sometimes only exacerbate the situation. In this context, a well-coordinated and close cooperation between representatives of the health system, scientists and the media is necessary. State should not allow the spread of fakes, or vice versa, withhold information. The average citizen cannot and does not have to be a scientist to understand a situation. Moreover, the main task of the media is to convey reliable information not through scary headlines, but through proven science-based information. Oftentimes, politicians or lawyers with no medical knowledge make decisions that are medically unfounded. However, there are also opposite situations, when the opinion of a specialist is expressed in the media, but it is so full of terminology that it is not clear to readers or viewers.
From a historical point of view, the significance of the pandemic in our opinion should be assessed as a unique experience, thanks to which people got the opportunity to re-evaluate approaches to the digital transformation of society, rethink its economic, socio-political, ecological fields and outline the main conclusions about the priorities for the further development of humanity.
For Azerbaijan as well as other countries, it is necessary to develop popular science journalism. Such journalism should research on how to balance the information flow during such a hard times as a pandemic. It is necessary to conduct an objective assessment of media work, effectiveness of healthcare management, identify its weak sides and develop new strategies. The organisation of the healthcare system should ensure its preparedness for extreme situations such as pandemic.
We hope people will not face such pandemics in the future but we – the world community must be prepared for that and do not let panic destroy our lives.
"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges".
\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.
",metaTitle:"About Open Access",metaDescription:"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges.\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.",metaKeywords:null,canonicalURL:"about-open-access",contentRaw:'[{"type":"htmlEditorComponent","content":"The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\\n\\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
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The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\n\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\n\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\n\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\n\nOAI-PMH
\n\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\n\nLicense
\n\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\n\nPeer Review Policies
\n\nAll scientific works are Peer Reviewed prior to publishing. Read more
\n\nOA Publishing Fees
\n\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\n\nDigital Archiving Policy
\n\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
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\n\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
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There are various sources of these antioxidants like endogenous antioxidant present in the body and exogenous food source. In recent decades, alternate of synthetic food antioxidants by natural ones has fostered interest on vegetable sources and the screening of inexpensive raw materials particularly from the agriculture for identifying new antioxidants. Polyphenols are the significant plant compounds with antioxidant activity, though not the only ones. Some but not only restricted to biological properties such as anticarcinogenicity, antimutagenicity, antiallergenicity, and antiaging activity have been reported for natural and synthetic antioxidants. Among the sources of natural antioxidants, the most important are those coming from routinely consuming vegetables and fruits; however, antioxidant from other plant and agriculture waste should not be ignored.",book:{id:"6678",slug:"antioxidants-in-foods-and-its-applications",title:"Antioxidants in Foods and Its Applications",fullTitle:"Antioxidants in Foods and Its Applications"},signatures:"Haseeb Anwar, Ghulam Hussain and Imtiaz Mustafa",authors:[{id:"240684",title:"Dr.",name:"Haseeb",middleName:null,surname:"Anwar",slug:"haseeb-anwar",fullName:"Haseeb Anwar"},{id:"244522",title:"Dr.",name:"Ghulam",middleName:null,surname:"Hussain",slug:"ghulam-hussain",fullName:"Ghulam Hussain"},{id:"244523",title:"Ms.",name:"Jaweria",middleName:null,surname:"Nisar",slug:"jaweria-nisar",fullName:"Jaweria Nisar"},{id:"244524",title:"Mr.",name:"Imtiaz",middleName:null,surname:"Mustafa",slug:"imtiaz-mustafa",fullName:"Imtiaz Mustafa"}]},{id:"19751",doi:"10.5772/18808",title:"From Soybean Phytosterols to Steroid Hormones",slug:"from-soybean-phytosterols-to-steroid-hormones",totalDownloads:11618,totalCrossrefCites:19,totalDimensionsCites:38,abstract:null,book:{id:"496",slug:"soybean-and-health",title:"Soybean and Health",fullTitle:"Soybean and Health"},signatures:"Feng-Qing Wang, Kang Yao and Dong-Zhi Wei",authors:[{id:"32646",title:"Dr.",name:"Feng-Qing",middleName:null,surname:"Wang",slug:"feng-qing-wang",fullName:"Feng-Qing Wang"},{id:"32662",title:"MSc.",name:"Kang",middleName:null,surname:"Yao",slug:"kang-yao",fullName:"Kang Yao"},{id:"32663",title:"Prof.",name:"Dong-Zhi",middleName:null,surname:"Wei",slug:"dong-zhi-wei",fullName:"Dong-Zhi Wei"}]}],mostDownloadedChaptersLast30Days:[{id:"64570",title:"Banana Pseudo-Stem Fiber: Preparation, Characteristics, and Applications",slug:"banana-pseudo-stem-fiber-preparation-characteristics-and-applications",totalDownloads:9429,totalCrossrefCites:15,totalDimensionsCites:18,abstract:"Banana is one of the most well-known and useful plants in the world. Almost all the parts of this plant, that are, fruit, leaves, flower bud, trunk, and pseudo-stem, can be utilized. This chapter deals with the fiber extracted from the pseudo-stem of the banana plant. It discusses the production of banana pseudo-stem fiber, which includes plantation and harvesting; extraction of banana pseudo-stem fiber; retting; and degumming of the fiber. It also deals with the characteristics of the banana pseudo-stem fiber, such as morphological, physical and mechanical, durability, degradability, thermal, chemical, and antibacterial properties. Several potential applications of this fiber are also mentioned, such as the use of this fiber to fabricate rope, place mats, paper cardboard, string thread, tea bags, high-quality textile materials, absorbent, polymer/fiber composites, etc.",book:{id:"7544",slug:"banana-nutrition-function-and-processing-kinetics",title:"Banana Nutrition",fullTitle:"Banana Nutrition - Function and Processing Kinetics"},signatures:"Asmanto Subagyo and Achmad Chafidz",authors:[{id:"257742",title:"M.Sc.",name:"Achmad",middleName:null,surname:"Chafidz",slug:"achmad-chafidz",fullName:"Achmad Chafidz"},{id:"268400",title:"Mr.",name:"Asmanto",middleName:null,surname:"Subagyo",slug:"asmanto-subagyo",fullName:"Asmanto Subagyo"}]},{id:"61245",title:"Nutritional Composition of Meat",slug:"nutritional-composition-of-meat",totalDownloads:4483,totalCrossrefCites:32,totalDimensionsCites:58,abstract:"Meat ranks among one of the most significant, nutritious and favored food item available to masses, which aids in fulfilling most of their body requirements. It has played a vital role in human evolution and is an imperative constituent of a well-balanced diet. It is a good source of proteins, zinc, iron, selenium, and phosphorus followed by vitamin A and B-complex vitamins. Average value of meat protein is about 23% that varies from higher to lower value according to the type of meat source. Meat fat and its fatty acid profile is point to worry, with respect to its consumption, but its moderate usage is always advised by doctors and nutritionists, in order to lead a healthy life. Fat content of animal carcasses ranges between 8 and 20%. Quality traits of meat along with its nutritional composition become dependent upon animal breed type, feeding source (grains, pasture and grass), genetics of animal and post mortem techniques. This chapter will mainly focus on the variant aspects of nutritional constituents of meat including proteins and essential amino acids, fats and fatty acid profile, carbohydrates, vitamins and minerals along with their health benefits to human health.",book:{id:"6669",slug:"meat-science-and-nutrition",title:"Meat Science and Nutrition",fullTitle:"Meat Science and Nutrition"},signatures:"Rabia Shabir Ahmad, Ali Imran and Muhammad Bilal Hussain",authors:[{id:"235082",title:"Dr.",name:"Ali",middleName:null,surname:"Imran",slug:"ali-imran",fullName:"Ali Imran"},{id:"239057",title:"Dr.",name:"Rabia Shabir",middleName:null,surname:"Ahmad",slug:"rabia-shabir-ahmad",fullName:"Rabia Shabir Ahmad"},{id:"243634",title:"Mr.",name:"Muhammad Bilal",middleName:null,surname:"Hussain",slug:"muhammad-bilal-hussain",fullName:"Muhammad Bilal Hussain"}]},{id:"67214",title:"Microbial Contamination in Milk Quality and Health Risk of the Consumers of Raw Milk and Dairy Products",slug:"microbial-contamination-in-milk-quality-and-health-risk-of-the-consumers-of-raw-milk-and-dairy-produ",totalDownloads:3581,totalCrossrefCites:11,totalDimensionsCites:22,abstract:"The dairy products industry is going toward safe milk and its products in the food market. Milk quality and food safety concern in the consumers’ health and nutrition in public health surveillance prevent food-borne diseases, food poisoning, and zoonosis risk by raw milk and fresh dairy products. The aim of this work is focused on milk microbial contamination and its impacts on milk production and dairy industry with their implications in milk product quality, food-borne diseases from raw milk, and unpasteurized milk by food-borne pathogen microbial contamination and milk and dairy product spoilage. The microbial milk contamination source comes from herd hygiene and health status, mastitis prevalence, production environment, and milking parlor and milk conserving practices in dairy farm. Moreover, these facts are implicated in milk quality and milk spoilage and unsafe dairy products. The milk production system and the dairy plant operations keep track in pasteurized milk and fresh dairy products reviewing the traceability in field situational diagnosis report.",book:{id:"7943",slug:"nutrition-in-health-and-disease-our-challenges-now-and-forthcoming-time",title:"Nutrition in Health and Disease",fullTitle:"Nutrition in Health and Disease - Our Challenges Now and Forthcoming Time"},signatures:"Valente Velázquez-Ordoñez, Benjamín Valladares-Carranza, Esvieta Tenorio-Borroto, Martín Talavera-Rojas, Jorge Antonio Varela-Guerrero, Jorge Acosta-Dibarrat, Florencia Puigvert, Lucia Grille, Álvaro González Revello and Lucia Pareja",authors:[{id:"15423",title:"Qco.",name:"Lucia",middleName:null,surname:"Pareja",slug:"lucia-pareja",fullName:"Lucia Pareja"},{id:"199849",title:"Dr.",name:"Velazquez",middleName:"Ordoñez",surname:"Valente",slug:"velazquez-valente",fullName:"Velazquez Valente"},{id:"280178",title:"Dr.",name:"Esvieta",middleName:null,surname:"Tenorio-Borroto",slug:"esvieta-tenorio-borroto",fullName:"Esvieta Tenorio-Borroto"},{id:"280179",title:"Dr.",name:"Benjamín",middleName:null,surname:"Valladares-Carranza",slug:"benjamin-valladares-carranza",fullName:"Benjamín Valladares-Carranza"},{id:"280184",title:"Dr.",name:"Jorge",middleName:null,surname:"Acosta-Dibarrat",slug:"jorge-acosta-dibarrat",fullName:"Jorge Acosta-Dibarrat"},{id:"285302",title:"Dr.",name:"Martín",middleName:null,surname:"Talavera Rojas",slug:"martin-talavera-rojas",fullName:"Martín Talavera Rojas"},{id:"285303",title:"Dr.",name:"Lucia",middleName:null,surname:"Grille",slug:"lucia-grille",fullName:"Lucia Grille"},{id:"291633",title:"Dr.",name:"Alvaro",middleName:null,surname:"González Revello",slug:"alvaro-gonzalez-revello",fullName:"Alvaro González Revello"},{id:"301478",title:"Ph.D. Student",name:"Jorge Antonio",middleName:null,surname:"Varela-Guerrero",slug:"jorge-antonio-varela-guerrero",fullName:"Jorge Antonio Varela-Guerrero"},{id:"301479",title:"Ph.D. Student",name:"Florencia",middleName:null,surname:"Puigvert",slug:"florencia-puigvert",fullName:"Florencia Puigvert"}]},{id:"60461",title:"Biological Activities of the Doum Palm (Hyphaene thebaica L.) Extract and Its Bioactive Components",slug:"biological-activities-of-the-doum-palm-hyphaene-thebaica-l-extract-and-its-bioactive-components",totalDownloads:4246,totalCrossrefCites:7,totalDimensionsCites:13,abstract:"The doum palm (Hyphaene thebaica) is a type palm tree which has a wood texture and has edible oval fruits and the origin native to upper Egypt. The trunk of this small palm is dichotomous. It is one of the most important useful plants in the world. All parts of doum palm have a useful role such as fiber and leaflets which used to weave baskets and doum nuts which have antioxidants and secondary metabolites such as tannins, phenols, saponin, steroids, glycosides, flavonoid, terpenes and terpinoids. Also, roots, stems and leaves are used in medicine, ropes and baskets. Studies on anti-inflammatory, antioxidant, antimicrobial, anticancer and pharmacological potential of Hyphaene thebaica extracts and its major phytoconstituents like the phenolic, essential oil and flavonoid compounds are extensively discussed in this review.",book:{id:"6678",slug:"antioxidants-in-foods-and-its-applications",title:"Antioxidants in Foods and Its Applications",fullTitle:"Antioxidants in Foods and Its Applications"},signatures:"Hossam S. El-Beltagi, Heba I. Mohamed, Hany N. Yousef and Eman\nM. Fawzi",authors:[{id:"138817",title:"Dr.",name:"Heba",middleName:null,surname:"Mohamed",slug:"heba-mohamed",fullName:"Heba Mohamed"},{id:"240003",title:"Prof.",name:"Hossam",middleName:"Saad",surname:"El-Beltagi",slug:"hossam-el-beltagi",fullName:"Hossam El-Beltagi"},{id:"251695",title:"Prof.",name:"Eman",middleName:null,surname:"Fawzi",slug:"eman-fawzi",fullName:"Eman Fawzi"},{id:"251950",title:"Dr.",name:"Hany",middleName:null,surname:"Yousef",slug:"hany-yousef",fullName:"Hany Yousef"}]},{id:"71665",title:"Global Prevalence of Malnutrition: Evidence from Literature",slug:"global-prevalence-of-malnutrition-evidence-from-literature",totalDownloads:2054,totalCrossrefCites:7,totalDimensionsCites:13,abstract:"Malnutrition is a widespread problem, affecting the global population at some life stage. This public health epidemic targets everyone, but the most vulnerable groups are poverty-stricken people, young children, adolescents, older people, those who are with illness and have a compromised immune system, as well as lactating and pregnant women. Malnutrition includes both undernutrition (wasting, stunting, underweight, and mineral- and vitamin-related malnutrition) and overnutrition (overweight, obesity, and diet-related noncommunicable diseases). In combating malnutrition, healthcare costs increase, productivity is reduced, and economic growth is staggered, thus perpetuating the cycle of ill health and poverty. The best-targeted age for addressing malnutrition is the first 1000 days of life as this window period is ideal for intervention implementation and tracking for the improvement of child growth and development. There is an unprecedented opportunity to address the various forms of malnutrition, especially the 2016–2025 Decade of Action on Nutrition set by the United Nation. This aims to achieve the relevant targets of the Sustainable Development Goals that aim to end hunger and improve nutrition, as well as promote well-being and ensure healthy lives.",book:{id:"8030",slug:"malnutrition",title:"Malnutrition",fullTitle:"Malnutrition"},signatures:"Natisha Dukhi",authors:[{id:"311182",title:"Dr.",name:"Natisha",middleName:null,surname:"Dukhi",slug:"natisha-dukhi",fullName:"Natisha Dukhi"}]}],onlineFirstChaptersFilter:{topicId:"323",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"June 29th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:32,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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