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",isbn:"978-1-83768-165-5",printIsbn:"978-1-83768-164-8",pdfIsbn:"978-1-83768-166-2",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"681a60ff84a29b9f72de9b662bab9c38",bookSignature:"Prof. Shailendra K. Saxena",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/12104.jpg",keywords:"Viral Outbreak, Viral Epidemic, Viral Pandemic, Disease Outbreak Detection, COVID-19, Nipah, Ebola, MERS, Pathogenesis, Host-Pathogen Interaction, Immunity, Antiviral",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 25th 2022",dateEndSecondStepPublish:"June 22nd 2022",dateEndThirdStepPublish:"August 21st 2022",dateEndFourthStepPublish:"November 9th 2022",dateEndFifthStepPublish:"January 8th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"25 days",secondStepPassed:!1,areRegistrationsClosed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"Prof. Dr. Shailendra K. has received many awards and honors in India and abroad, including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various prestigious international societies/academies, including the Royal College of Pathologists, United Kingdom; Royal Society of MedProf. He is the vice dean and Professor at King George\\'s Medical University, Lucknow.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"13",totalChapterViews:"0",totalEditedBooks:"8",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"441704",firstName:"Ana",lastName:"Javor",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/441704/images/20009_n.jpg",email:"ana.j@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. 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This new concept of smarter grids, known as smart grids, is incorporating automation technologies and communication in real time to the grid, with more intelligent devices, distributed generators’ connection and instant forward actions to electrical problems. These changes in the distribution system enable greater diversity in services related to energy, such as demand management, the use of distributed generation from renewable sources, connection of electric vehicles, and voltage maintenance after self‐healing, among others.
\nIn this sense, this chapter presents a new methodology and a software tool for real‐time reconfiguration of distribution network considering distributed generation units the renewable sources. The work of [1, 2] indicates that this system has a good performance, applying smart grids concepts, from the information and functionality of remote‐controlled equipment installed in the distribution test systems.
\nThis chapter is divided into five sections. The second section presents the main concepts that guide the smart grids. Following is shown the distributed generation technologies to the application exposed in this work. The fourth section presents the reconfiguration methodology developed in real time. Then, the results and discussions are exposed considering a large real distribution system. Finally, the main conclusions are presented in the last section.
\nThe smart grids represent a new paradigm in the way power systems are designed and operated. They are characterized by the integration of well‐established technologies and concepts that together seek to respond to the increased demand and requirements regarding quality and sustainability in the energy sector [3]. The resources available from technological advances in telecommunication and automation have brought benefits to the grid, especially: fast processing and information exchange between network devices, allowing real‐time monitoring and control; cost and time reduction with maintenance teams; the possibility of creating more robust and reliable systems and less susceptible to human limitations; and the integration of network structures, such as distributed generation, stability control, and demand control.
\nHowever, the benefits of the technology are often economically viable only if the automated system is part of a larger whole, provided with a degree of intelligence. This applies, for example, for the automatic network restoration, in which the automatic operation of remotely controlled switches must be integrated with the detection and isolation of the fault systems, ensuring the restoration of the largest possible number of consumers. In this case, the system\'s intelligence can be represented by the response of computer programs that employ optimization techniques and support decision‐making.
\nA general illustration of some features and elements of the smart grids is highlighted in Figure 1. From the bottom to the top, the figure shows the main interfaces between the power utility services and equipment, and the consumer and/or micro generator. The middle layer of the figure gives some examples of structures that can be related either to power utilities or to consumers. A brief discussion on the main concepts shown in the Figure 1 is presented in this section.
\nA general view of a smart grid.
The demand response refers to the ability of management and control of power system loads. The primary goal of DR was to reduce peak consumption by turning off loads in higher power consumption schedules. Alternatively, consumption can be shifted to off‐peak periods or even can be increased at certain periods, to maintain the stability of generation or to make the most of the available resources, such as energy from distributed generation [4].
\nThe implementation of DR is done through electronic devices that communicate with the power utility and receive commands to turn off the loads connected to them, according to the request of the utility or to the energy rate variation. Previously, a priority study of the loads must be done to avoid interruptions that may harm important services to the consumer.
\nThe demand response is one of the challenges of the energy market facing the smart grids. It can promote greater pressure to reduce prices and increase concern about the use of energy by consumers. From the utility\'s viewpoint, it may result in a change in load curves and reduction of the peak consumption, which implies lower need for investment in energy reserves. On the other hand, the biggest challenges are the consumers’ behavior change, the need for compatible technology—such as advanced metering structures—and the efficiency of government agencies in regulating and supervising the process.
\nAdvanced metering infrastructure comprises all the elements needed for the measurement and communication between consumers and suppliers. The communication in this case is bidirectional and allows, for example, that a power utility sends to the consumer the real‐time energy pricing. Integration with demand response devices allows load management according to the change in the price or according to the need of the power utility.
\nThe advanced metering infrastructure consists of electronic meters, communication networks, and a data management system (MDMS, meter data management system), which is responsible for storing and managing the large amount of data from the power meters and establish interface between the data collected and other features of the network, such as the billing system and maintenance teams, for example.
\nThe advantages of AMIs include the possibility of monitoring the energy billing in real time by the consumer, fast detection of measurement failures and non‐technical losses, and the creation of consumer profiles for demand response programs and fast response to energy restoration systems. AMIs also allow the creation of more accurate consumer databases for profiles and demand estimation studies and provide real‐time measurements that help in decision‐making regarding the system operation. The technological challenges of AMIs include the need for standardization of communication and interfaces between devices, and security issues to ensure that only authorized devices could access the network information [5].
\nThe smart meter may be considered as an evolution of the automatic electronic power meter. The main feature of smart meters is the two‐way communication, which makes it possible to receive real‐time power utility commands.
\nThe standard of communication varies depending on the smart meter application project. In some countries, for example, power meters communicate through wire with a data concentrator and the data concentrator communicates with a central by a wireless network. Many smart meters, however, have wireless communication capability directly to the operation center.
\nCommunication can be considered the biggest challenge of deploying smart meters. A wide variety of protocols and possible ways of communication is used, and there is no universal standardization of power meters. Possible arrangements of networks include the use of cellular networks, satellite communications, radio frequency, Wi‐Fi, power line communication, directly to a central or a data concentrator, or in cascade mode communicating through a mesh network. The main protocols used are defined by ANSI C12.18 standard in the United States, and IEC 61107/62056 in Europe. Regardless of the type of communication, the discussion about the project to be adopted involves cost, safety, and health.
\nSome common features in smart meters include possibility of remote connection and shutdown of the energy point, grid failure warning, fraud warning, real‐time monitoring of energy bill, and demand control. In some projects, smart meters also have the ability to communicate with user internal devices. For example, in a residence, the smart meter can receive or send information to and from appliances, air‐conditioning units. This concept is based on the home area network and enables the timely management of user loads.
\nThe smart grids led to concerns about changes in consumer load profiles, and the prospect of increased plug‐in hybrid electric vehicles (PHEV) connected to the power system is one of the most discussed points [6]. Electric vehicles are characterized by substituting fully or partially (in case of hybrid vehicles) the traditional internal combustion motor by electric motors for vehicle propulsion. Electric motors are typically powered by batteries; and if the batteries are recharged through the electric distribution network, the vehicles are called plug‐in.
\nThe impact of PHEVs in power systems is significant, and several studies highlight the need for planning of battery recharges, to avoid concentration of PHEVs overloading the system, and solutions based on the use of the vehicle to inject energy into the network during peak periods (vehicle‐to‐grid).
\nThe smart grids shall be prepared to absorb this new type of demand. Some aggravating quality factors in power systems can be cited: power imbalances (in case of single‐phase chargers), harmonics, and increased voltage drops and losses, particularly in feeders with large extensions. Furthermore, the capacity of distributions transformers may be easily extrapolated if a large amount of PHEVs is loaded simultaneously.
\nDistributed generation (DG) normally employs renewable energy sources, mainly wind and photovoltaic, due to difficulties of building small conventional power plants, such as hydro and thermal coal, close to consumption centers.
\nIn residences, photovoltaic energy has the advantages of cost and modularity to install in roofs—in the power range up to 10 kW. Figure 2 shows a typical arrangement of a photovoltaic microgeneration connected to the grid, which includes a set of batteries for energy storage, power electronics circuits (charge control and inverters), and a bidirectional power meter.
\nSmall‐scale generation connected to the grid.
To take advantage of DG, smart grids have to include advanced mechanisms of generation estimation, short‐ and long‐term ability to quickly regulate power and energy storage, and management of distributed resources in conjunction with the demand response [7]. The main technical issues involved are related to power quality, stability, and protection, due to the intermittent characteristic of the primary sources.
\nA high level of automation and information technology (IT) is expected in a smart grid. The network infrastructure must support data management of electronic meters (MDMS), monitoring and control of network status (overload, reactive power control, etc.), load and distributed generation management, charging of PHEVs, among other features. Information systems should communicate with each other at different levels of implementation, such as power regulation strategies, billing, maintenance management, consumer and network databases, geographic information systems (GIS), among others. Interoperability between standards and communication protocols plays a critical role in the advancement of smart grids. An important reference guide is published by the National Institute of Standards and Technology (NIST) [8].
\nAt the operation center, the supervisory systems (SCADA) perform the interface between the technical team (operator, planner, supervisor, etc.) and the network devices. At the distribution network, some automation features may include automatic adjustment of protection devices, automatic regulation of voltage levels, control of capacitor banks and transformers’ taps, control of distributed generation, self‐reconfiguration, in addition to the automatic management of loads and consumption measurements. Furthermore, the automation requires the employment of remote‐controlled equipment (switches, reclosers, circuit breakers, etc.), and digital controllers and intelligent electronic devices (IEDs).
\nWith the advancement of the smart grids, the profile of the load curves of distribution feeders will be subject to a different dynamic behavior. Some features, such as increased use of distributed generation, demand response, and charging of electric vehicles, will require a fast network response for new generation and load scenarios. The automatic reconfiguration in real time will help to improve the network performance and to promote more efficient use of the smart grids resources.
\nThe concept of distributed generation refers to the use of small generators directly connected to the distribution network or the local network of consumers. Among the current generation sources stand out wind power, photovoltaic, hydroelectric, and diesel. Thermal power plants and biomass have also been employed in DG, but on a smaller scale.
\nThe wind power harnessing is obtained from the kinetic energy conversion of the air masses through translational movement in rotational kinetic energy, using a wind turbine or wind generator for electricity generation. Figure 3 illustrates the typical components of a wind turbine: rotor, nacelle, generator, sensors, among others.
\nThe rotor is responsible for transforming the kinetic energy of wind in mechanical energy of rotation. The turbine blades are fixed in the rotor, which in turn is connected to a hub interconnected to the generator through a gearbox. The mechanisms to allow operation of the generator are located in the nacelle, for example, the turning control, the brake system, the wind sensors, among others.
\nOnly part of the extracted wind power can be used to generate electricity. The amount of energy that can be converted into electricity is obtained by the power coefficient of the wind turbine
where
Schematic of a wind turbine generating power.
Photovoltaic generation uses semiconductor elements capable to generate electricity from the direct conversion of solar energy in electrical energy through solar cells (photovoltaic). Although it can be straightforward, this conversion process depends on the characteristics of each semiconductor and quality of the materials employed in manufacturing technology.
\nOne of the key aspects for the photovoltaic systems implementation is the knowledge of local solar radiation characteristics. These data may be obtained through the meteorological data base information. Solar radiation and temperature are the major variables that affect the generated power of the photovoltaic cells. To illustrate these effects, characteristic curves were obtained with the PV module parameters (245 W KD245GH) of the Kyocera manufacturer [11]. Figure 4a shows the
(a) Current and (b) voltage characteristics for the KD245GH module.
The photovoltaic systems’ behavior is usually characterized by measuring the voltage and current curves (
However, STC conditions rarely occur in real operating conditions. Consequently, the estimation of the PV modules behavior requires extrapolation from the standpoint of real operating conditions.
\nCurrently, there is no standard methodology for assessing the electricity production of PV modules. There are typically two methods of assessing the amount of maximum power that modules produce numerical methods and algebraic methods [12, 13]. The numerical procedures are used to calculate the instantaneous power peak of the curve
The method of Osterwald is one of the algebraic methods most commonly used because of the simplicity. It allows calculating the output power of a photovoltaic system for any amount of irradiation and cell temperature. Equation (2) shows the method of Osterwald [14]:\n
where
The energy generation through the hydraulic potential for exploitation in a river can be characterized in different ways: When there is a concentrated unevenness in a waterfall, featuring a natural advantage, through a barrage with small unevenness, or through diversion of river from its natural course. The water is conducted through canals, tunnels, or penstocks and transformed into kinetic energy by spinning of turbine blades; this motion produces electrical power from the drive shaft of a generator.
\nSmall hydro power (SHP) currently accounts for a fast and efficient way to promote the expansion of supply of electricity. This type of project enables better compliance with the consumers’ requirement of small urban centers and rural areas, complementing the power supply performed by the conventional system.
\nRegarding operating philosophies, SHPs have great flexibility, having two main forms of reservoirs regularization: the river or storage, with daily regulation reservoir, and the dispatched power depends on the physical characteristics and techniques and also the central philosophy of the undertaking that holds.
\nThe estimated output power for a hydraulic turbine can be obtained in relation to the height of the available downfall and of the flow of the hydraulic turbine, considered constant. Generally, the turbines models of Pelton, Francis, Kaplan, and Bulb are used for small hydro projects. The choice considering one or other model is defined according to the height of fall characteristics, water flow, and rotation of the turbine generator set.
\nIn general terms, the power of a turbine can be expressed as the sum of the three forms of energy of Bernoulli\'s theorem [9], as represented in Eq. (3).\n
where
The output power of the turbine shaft in a hydroelectric system can be obtained through Eq. (4) [15].\n
where
The reconfiguration of the distribution network is considered an optimization problem in that search, among the various solutions (topologies) possible, the solution that leads to better performance, considering the ultimate goal of reconfiguration and observing the network constraints. One factor that increases the complexity of the problem is the high number of switching devices in a real network, which results in a lot of different possible configurations to be analyzed.
\nIn general, it may be impractical to test all possible combinations and perform, for each of the calculations needed—such as power flow and reliability indicators—in order to identify the setting that results in the best performance. To solve the problem, optimization methods that reduce the search space of the optimal solution are used.
\nAnother problem is that the optimal solution found meets a given situation of power generation and consumption, which typically varies over a period. The load variation during the day, for example, can modify the parameters for which the topology is optimized, resulting in a new optimum configuration. At this point, the solution for the reconfiguration of the network must come from at least two premises:
The network must be flexible to allow the reconfiguration, whenever observed the need; and
It is necessary to establish a cost–benefit relationship to determine the necessity and the effectiveness of the reconfiguration;
The diagram in Figure 5 shows the architecture employed in this work to meet these premises. The SCADA program is the main interface between the real‐time reconfiguration program developed and the equipment in distribution network.
\nThe first premise is to facilitate the implementation of the reconfiguration, so there is an effective gain with the network topology change. The use of remote‐controlled equipment such as switches and reclosers is a solution that meets this premise on two aspects: The reconfiguration can be automated without the need to displacement teams to operate the equipment, and immediate, or can be performed at the time wherein determining its need.
\nArchitecture of the developed system.
The second premise aims to limit the wear of the switching equipment. One solution is to establish relevant levels change in the network (e.g., demand) and parameters utilized as the aim of reconfiguration (e.g., energy losses), and conditioning reset only to cases in which the alteration levels exceed the reference values.
\nIn order to obtain a good discretization of the demand curve and generation curve to avoid frequent reconfigurations in the network, it is employed a set of six demand rates. The rates are constructed from the average of historical data (typical daily demand curve). The representative demand for one entire period is the maximum value observed in it and the case of generation curve it is used the average output power.
\nFigure 6 exemplifies the discretization of typical curves; Figure 6a shows the demand curves of an industrial feeder; and Figure 6b shows a wind turbine generation curve.
\nDiscretization of typical curves of (a) an industrial feeder, (b) a wind turbine.
The first stage of the optimization process is to define the objective function (FO) and constraints of the problem. The OF includes the minimization of network indicators:
Expected loss of energy in the primary network (
Expected index of interruption frequency in the system (
Expected value of energy not supplied (
These three indicators can identify each of the alternatives, and reconfiguration is shown in Eq. (5).\n
Subject to:\n
where
Several optimization methods are proposed to solve the reconfiguration problem of distribution networks. The search techniques can be classified into different categories: heuristics, meta‐heuristics, expert systems, and mathematical programming [16]. Following is detailed one of heuristic search techniques, and considerations are then presented to illustrate a reconfiguration of application example using this technique in a real network model. The heuristic search technique, also known as branch exchange, is based on a local search, where the algorithm looks for a new solution from neighboring configurations in each iteration.
\nIn power systems, the method is premised on the radial configuration of the network. This method consists in carrying out successive changes in network configuration (e.g., opening a switch and closing another), so that each search tree node represents a possible solution of the problem. If the objective function indicators decrease, there is a new solution, and the algorithm continues the search process until no further improvement occurs. The technique can best be understood in two stages:
Step A: Analysis of interconnections between feeders in situations where there are not distributed generators connected to the distribution network [17] and
Step B: Analysis of interconnections in situations where there are distributed generators connected to the distribution network [1, 2].
Figure 7 illustrates the flow chart includes the Stage A and Stage B of heuristic search technique for reconfiguration of distribution networks.
\nFlowchart from step A and step B of heuristic search technique for reconfiguration of distribution networks.
The reconfiguration of the distribution network can involve optimization criteria that result in conflicting solutions. For example, considering the minimization of losses and increased reliability, a network topology can represent the optimal solution that meets the first criterion is, however, not represent the optimum solution to the second criterion.
\nA usual method of multicriteria analysis‐based decision‐making is the analytic hierarchy process (AHP) proposed by Saaty [18]. In AHP, the degree of preference of one over another objective is quantified through a table of the method suggested by the author, and the relationship between alternatives is represented by a matrix. A detailed description of AHP calculation methodology used in this work is presented in [17], which obtained as results for the indicators of the OF: w1 (
The proposed methodology was verified through several tests on the concession area of a power utility of Brazil. The real distribution network model presented in Figure 8 is used as a case study, and this network has the following:\n
Two substations with voltage 69/13.8 kV;
Five feeders: FD‐101; FD‐102; and FD 103 connected from the Substation A; and FD‐104 and FD‐105 connected from the Substation B;
15 tie‐switches remote‐controlled (TS) in normally open state, named and numbered as TS‐1 to TS‐15;
143 remote‐controlled switches (S) in normally closed state The manual switches which are not part of the tests are omitted in the representation of the network.
Solar photovoltaic plant of 500 kW, located between the S11 and S12 switches;
Wind power plant of 1600 kW, located between the TS‐10 and S39 switches;
Hydroelectric power plant (SHP) of 1000 kW, located between the TS‐15 and S61 switches.
The original configuration of this system is shown in Figure 8, where it is important to highlight the interconnection switches and the distributed generation plants.
\nThe analysis is done considering the expected maximum values of demand feeders and the average availability of active power generation by source of DG during the period corresponding to each of the six levels, as shown in Figure 9. For the developed methodology exemplification, only the results of level 5 are detailed (18h00–20h59).
\nNetwork distribution with DG.
Demand evaluation and generation.
The reconfiguration algorithm is applied considering the individual analysis of each switch interconnection shown in Figure 8. The individual analysis of the tie‐switches leads to the results shown in Figure 10. Only the cases where the objective functions analyzed presented positive evolution are shown.
\nThe results of objective function in Eq. (5) are sorted from lowest to highest value to give the best switching sequence. These results of the objective function represent the individual changes made in the network and its effects, as can be seen in Figure 10a for energy losses, Figure 10b for ESAIFI and Figure 10c for EENS.
\nThese sorted results represent one switching sequence that should be performed by reapplying the branch exchange according to the defined order. The best configuration achieved with one tie‐switch is preserved as the initial configuration to the following tie‐switch to be tested. The final result of the network optimization to the analyzed rate demand is shown in Figure 11.
\nResults for the individual analysis of tie-switches. (a) Energy losses. (b) ESAIFI. (c) EENS.
Final results of reconfiguration analysis.
The final result of the optimization of the network to the rate demand analyzed is shown in Figure 12 which shows the loads distribution between the analyzed feeders; Figure 12a shows the original configuration; and Figure 12b shows the network configuration after changes. All procedures of the main software were successfully performed to give the best network topology that improves the FO indicators.
\nLoad distribution between the distribution network feeders: (a) original configuration and (b) after changes reconfiguration.
In this chapter, a novel methodology for real‐time reconfiguration of power distribution networks considering distributed generation units was presented. The main advantages of the proposed system are automatic change of the network topology based on load rate analysis, modelling, and DG profile from distinct generation sources; multicriteria decision‐making is given by the AHP method to choose the switching sequence and, finally, the computational analysis, the supervisory control, and the data acquisition of remote‐controlled switches are integrated to perform the real‐time reconfiguration. The switching is performed automatically, in the sequence determined by the software. Additionally, case studies are performed with real data from a power utility in Brazil, with the use of different operational scenarios that guarantee a real evaluation of the developed software performance. The results included in this chapter shown the feasibility of the proposed methodology, which assure the use of this system to other real networks with DG.
\nThe authors would like to thank the technical and financial support of AES Sul Distribuidora Gaúcha de Energia SA by project “Solução Inovadora para Gerenciamento Ativo de Sistemas de Distribuição” (P&D/ANEEL), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
\nMass spectrometry is an analytical technique whose purpose is discovering new molecules, determining quantities of known components and determining structural and chemical properties of a molecule.
The detection capability in mass spectrometry is very small, of about 10−12 grams and its application field is multifaceted, being used in industries such as: chemical, pharmaceutical, biotechnology, food, among others. It is frequently used in environmental and medical sciences, and in molecular biology.
Some of its most common uses are related to:
Performing doping tests in athletes [1].
Locating petroleum reservoirs through the use of precursors in the rocks [2].
Controlling fermentation of products in biotechnology processes [3].
Determining genetic damages [4].
Determining the presence of contaminants in food [5].
Identifying the structure of biomolecules, such as nucleic acids [4].
Analyzing the biodegradation of medications [6].
Establishing the age of geochemical and archeological samples [7].
The origin of mass spectrometry goes back to the experiments by J. J. Thompson, which evidenced, on one side, the presence of electrons, and on the other side, the presence of positive radiation, when energy falls into a vacuum tube to which a difference in electric potential was applied [8]. Thompson remarked the importance that this new technique might have in the field of chemical analysis and described it in his book “Rays of Positive Electricity and Their Application to Chemical Analysis” [9]; however, despite this interesting possibility of use, mass spectrometry was relegated to the field of experiments in physics. It was not until the 1940s, that the first analytical mass spectrometers started to be developed.
At present, Mass Spectrometry and Nuclear Magnetic Resonance, are the most complete and widespread techniques in educational and research labs around the world, regarding the study and discovery of organic molecules. In the field of natural products many of the studies about secondary metabolites have been validated in a mass spectrometer, since it is a very complete technique for the identification and control of this type of substances.
A mass spectrometer is an instrument with the capability of measuring the mass of a molecule after it has been ionized. Due to the extremely small mass of a molecule expressed in grams or kilograms, it is more convenient to measure its molecular mass, expressed as mols; for example, the mass of a hydrogen atom is 1.66 x 10−24 grams, but its mol is approximately 1 gram, or if it is desired in Daltons, considering that this unit is equivalent to 1/12 of the mass of an isotope carbon-12.
The spectrometry does not directly measure the mass of an isotope, but rather its mass-to-charge ratio of the ions that are formed (m/z), where z is the charge, most of the ions formed in the mass spectrometry have a value of charge of z = 1.
The mass spectrometers are constituted by various components, namely: 1) system for introducing the sample, 2) ionization source, 3) mass analyzer, 4) detection system and 5) data analysis system. Components 2, 3 and 4 should be necessarily subject to a vacuum system; a summarized scheme of the instrument may be seen in Figure 1.
Scheme of a mass spectrometer.
The parts that diversify and create the different instrumentation variants are the ionization source and the mass analyzer.
A classic system requires the formation of ions in gaseous phase; however, the latest instrumentation advances have generated methodologies that enable introducing molecules in liquid phase or even in solid phase. The process for generating the mass spectrum is:
Production of ions and fragmentation
Separation of the ions according to their mass-to-charge ratio
Detection
The ion production, also known as ionization, occurs in different manners. The classic one is by means of the interaction of an electric current (electronic ionization) with a substance in vapor phase. The energy is considered as high and has been standardized at 70 eV, which is greater than the energy of the bonds of any molecule.
Another method is chemical ionization (Cl) where the rupture is produced due to the incidence of a gaseous substance with an extra proton, for example CH5+, on substances in vapor phase. Chemical ionization is less energetic than electronic ionization and produces less fragmentation.
Other types of ionization of recent development are:
(Fast Atom Bombardment, FAB): impact of atoms at high velocity on a sample dissolved in a liquid matrix.
(Secondary Ion Mass Spectrometry, SIMS): impact of ions at high velocity on a thin film of sample deposited on a metal substrate, or dissolved in a liquid matrix (Liquid SIMS).
(Plasma Desorption, PD): impact of fragments of nuclear fission, for example, of the 252Cf on a solid sample deposited on a metal foil.
(Matrix Assisted Laser Desorption Ionization, MALDI): impact of high energy photons on a sample enclosed in an organic solid matrix.
(Field Desorption, FD): imposition of a strong electric field on a sample deposited on a special metal probe.
(Electrospray Ionization, ESI): formation of charged liquid particles which are emitted by desorption or desolvation.
The purpose of the mass analyzers is to separate the ions according to their mass-to-charge ratio. The mass analyzers have different features, namely:
Magnetic sector mass spectrometry. They deviate the trajectory of the ions in circular trajectories that depend on the momentum/charge ratio.
Quadrupole. Consists of 4 poles or bars arranged parallelly, the separation of the ions is the result of the application of a combination of continuous (DC) and alternating at a radiofrequency (RF) electric fields.
Ion trap. The ion trap operates similarly to the quadrupole, with the difference that it may hold and store the ions inside the trap.
Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR). The ions are trapped electrostatically in a cubic cell inside a constant magnetic field.
Time off flight (TOF). They separate ions according to the time employed to travel a particular distance; an ion of smaller mass will have a larger velocity, based on equation Ec = mv2/2 that relates kinetic energy with mass and velocity.
Figure 2 shows the ionization sources, as well as the diverse analyzers which will finally determine the types of instruments that are found in the market.
Ionization sources and analyzers in mass spectrometry.
In most mass spectrometry analyzers, with the exception of the FT-ICR, ions are detected after the separation, transforming the collision energy of the ions on the detector, in order to produce in it further emission of electron and photon ions that are opportunely measured in charge or light detectors.
A mass spectrometer of recent development is the orbitrap, which is a modification of the ionic trap; in this the ions are injected tangentially in an electric field, and they remain turning around a central electrode, highlighting a high mass resolution of them [10].
A mass spectrum consists of a diagram of ionic abundance as a function of its mass-to-charge ratio. The mass spectra are reported as simple histograms, such as the one seen in Figure 3.
Mass spectrum of the methanol.
In this example all the ions are positively charged; it is observed the molecular ion at a value m/z of 32, a majority ion at m/z 31 due to the loss of the H from the OH group, and an ion at m/z 15 which is due to the loss of the hydroxyl (OH).
Depending on the ionization source and the energy employed, spectra will be available with more or less positive fragments aside from the information about the molecular weight of the molecule.
High purity solid samples may be directly placed in a probe inside the instrument, in which it occurs the evaporation of the sample that has been introduced in the vacuum system. Gaseous or liquid samples require special systems for feeding the regulated flow.
When the sample to be analyzed is a complex mixture of compounds, chromatography equipment may be coupled to the mass spectrometer, such as gas chromatography (GC) or high-performance liquid chromatography (HPLC). The GC/MS systems were developed in the 60s, because the samples that enter to chromatographic column are already in gaseous phase and this facilitates its introduction in the mass spectrometer; an instrument of this type is observed in Figure 4. The coupling with liquid chromatography did not occur until the 80s, due to difficulty of producing an operational vacuum system.
Gas chromatography equipment coupled to mass spectrometer. Life Sciences Laboratory, Salesian Polytechnic University.
At present, the development of GC/MS and LC/MS systems provide a great variety of instruments that facilitate the separation and analysis work, both for quantifying as well as for discovering new structures, with the field of natural products being one of the most benefited from these latest advances.
The coupling of two MS–MS mass analysis states is useful for analyzing compounds in complex mixtures and for determining the structure of unknown molecules. The MS–MS evaluation offers the possibility of analyzing the ions formed in a further fragmentation of those ions formed in the first test.
If the first ionization technique offers the possibility of having various fragments in a highly purified sample, the second ionization offers the possibility of acquiring valuable structural information, and through it achieve a high possibility of determining the structure of a new molecule.
The high development achieved in the last hundred years by mass spectrometry with a great variability of techniques and instruments, makes possible that basically all molecules that are part of natural products may be analyzed, both qualitatively and quantitatively [11, 12], Figure 5 shows various spectra of natural substances obtained by electronic ionization. The extracts coming from biological matrices with natural products are generally a mixture of various compounds, and thus it is very common the use of GC or LC coupled systems [13, 14].
Spectra of natural molecules obtained by electronic ionization.
New techniques such as Electrospray Ionization, have increased the number of possible biomolecules to be analyzed, including those of high molecular weights [15]. Similarly, the use of powerful mass analyzers makes it possible to analyze molecular ions or fractionated ions with an extremely efficient resolution [16].
Essential oils are metabolites of volatile nature; therefore, studies of chemical composition are relatively simple, generally achieving percentages above 90% when investigating the molecules that compose these natural products [17, 18].
The combination of evaluations of mass spectra and retention indices provide information that may be verified in specific databases for this type of compounds [19]. Further studies of GC/MS in molecules separated in TLC, may reveal specific biological properties such as antibacterial or antioxidant [20].
Various plant species contain saturated and unsaturated fatty acids, studies are generally carried out by GC/MS, although the compounds of high molecular weight are non-volatile, this is solved employing chemical derivatization methodologies, forming methyl or ethyl esters [21, 22]. Numerous species of nutritional and pharmaceutical interest such as
The aromas and flavors in fruits and vegetables are fundamental for distinguishing their taste features, given their volatility the GC/MS equipment is the ideal for understanding the chemistry of this group of substances. Many of these molecules are very volatile and therefore are not removable in vapor stream, for introducing them in the chromatographic system they are previously extracted with non-polar solvents [26] or may be directly injected with head space introduction systems [27, 28].
Few phenolic compounds may be directly analyzed in an GC/MS system, generally those structures of low molecular weight [29].
Most of the phenolic and polyphenolic compounds are non-volatile and have two analytic paths for their structures to be determined, the first is through chemical derivatization, using the mechanism of sylitation, which make them volatile [30, 31].
The second is through instruments that couple HPLC to mass spectrometry, which has made that a large part of the tests are carried out directly, after their separation in one column. The advantage of the electrospray ionization technique is the possibility of ionizing molecules that lack of volatility [32, 33].
The use of mass analyzers of resolution greater than the quadrupole, such as the TOF or the orbitrap, has resulted in values of m/z that reach more precise levels, which has resulted in greater confidence in the identification of a substance [34, 35, 36].
The alkaloids are active ingredients whose structural feature is to have nitrogen in their structure, many of these molecules have a significant biological activity. Some alkaloids may be directly analyzed in GC/MS equipment, such as nicotine and other present in tobacco [37], caffeine and xanthine alkaloids [38, 39], and others whose volatility enables its separation in gas chromatography such as tropane alkaloids [40].
The most frequently used method in the test of these metabolites is the LC/MS in its diverse variants, such as the LC/MS [41], LC/MS–MS [42], some with a greater mass resolution such as the HPLC-TOF-MS [43]. The use of powerful mass analyzers such as Orbitrap, may lead to the discovery of new structures of this nature [44].
The cannabinols constitute a family of natural products of about 70 compounds, of which the most important are the THC and the CBD [45]. The discovery of the endocannabinoid 1 and endocannabinoid 2 systems, 4 decades ago, awakened the medicinal interest of these substances [46]. These compounds have a high solubility in non-polar solvents and are volatile at the injection temperatures in a gas chromatography equipment, consequently a qualification and quantification of them occur in a very good manner in GC/MS systems [47, 48]. The LC/MS is also useful in the analysis of these substances [49, 50].
Practically all the natural products may be analyzed by means of mass spectrometry, its high sensitivity and detailed structural information, make it an essential tool in research and product development labs.
Equipment with analyzers that have high resolutions can provide us with extremely exact values of molecular ions, and thus being able to differentiate the nature of the molecules.
At present there is a great variety of equipment coupled to LC or GC separation systems, which is ideal for the natural extracts that are generally a mixture of substances of diverse nature. Similarly, the combination of ionization and analyzer techniques, has been able to provide an instrumental variability that currently convert it in a technique highly appreciated for the discovery of new natural structures.
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There are various sources of these antioxidants like endogenous antioxidant present in the body and exogenous food source. In recent decades, alternate of synthetic food antioxidants by natural ones has fostered interest on vegetable sources and the screening of inexpensive raw materials particularly from the agriculture for identifying new antioxidants. Polyphenols are the significant plant compounds with antioxidant activity, though not the only ones. Some but not only restricted to biological properties such as anticarcinogenicity, antimutagenicity, antiallergenicity, and antiaging activity have been reported for natural and synthetic antioxidants. 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Almost all the parts of this plant, that are, fruit, leaves, flower bud, trunk, and pseudo-stem, can be utilized. This chapter deals with the fiber extracted from the pseudo-stem of the banana plant. It discusses the production of banana pseudo-stem fiber, which includes plantation and harvesting; extraction of banana pseudo-stem fiber; retting; and degumming of the fiber. It also deals with the characteristics of the banana pseudo-stem fiber, such as morphological, physical and mechanical, durability, degradability, thermal, chemical, and antibacterial properties. Several potential applications of this fiber are also mentioned, such as the use of this fiber to fabricate rope, place mats, paper cardboard, string thread, tea bags, high-quality textile materials, absorbent, polymer/fiber composites, etc.",book:{id:"7544",slug:"banana-nutrition-function-and-processing-kinetics",title:"Banana Nutrition",fullTitle:"Banana Nutrition - Function and Processing Kinetics"},signatures:"Asmanto Subagyo and Achmad Chafidz",authors:[{id:"257742",title:"M.Sc.",name:"Achmad",middleName:null,surname:"Chafidz",slug:"achmad-chafidz",fullName:"Achmad Chafidz"},{id:"268400",title:"Mr.",name:"Asmanto",middleName:null,surname:"Subagyo",slug:"asmanto-subagyo",fullName:"Asmanto Subagyo"}]},{id:"61245",title:"Nutritional Composition of Meat",slug:"nutritional-composition-of-meat",totalDownloads:4420,totalCrossrefCites:29,totalDimensionsCites:53,abstract:"Meat ranks among one of the most significant, nutritious and favored food item available to masses, which aids in fulfilling most of their body requirements. 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This chapter will mainly focus on the variant aspects of nutritional constituents of meat including proteins and essential amino acids, fats and fatty acid profile, carbohydrates, vitamins and minerals along with their health benefits to human health.",book:{id:"6669",slug:"meat-science-and-nutrition",title:"Meat Science and Nutrition",fullTitle:"Meat Science and Nutrition"},signatures:"Rabia Shabir Ahmad, Ali Imran and Muhammad Bilal Hussain",authors:[{id:"235082",title:"Dr.",name:"Ali",middleName:null,surname:"Imran",slug:"ali-imran",fullName:"Ali Imran"},{id:"239057",title:"Dr.",name:"Rabia Shabir",middleName:null,surname:"Ahmad",slug:"rabia-shabir-ahmad",fullName:"Rabia Shabir Ahmad"},{id:"243634",title:"Mr.",name:"Muhammad Bilal",middleName:null,surname:"Hussain",slug:"muhammad-bilal-hussain",fullName:"Muhammad Bilal Hussain"}]},{id:"67214",title:"Microbial Contamination in Milk Quality and Health Risk of the Consumers of Raw Milk and Dairy Products",slug:"microbial-contamination-in-milk-quality-and-health-risk-of-the-consumers-of-raw-milk-and-dairy-produ",totalDownloads:3540,totalCrossrefCites:11,totalDimensionsCites:22,abstract:"The dairy products industry is going toward safe milk and its products in the food market. Milk quality and food safety concern in the consumers’ health and nutrition in public health surveillance prevent food-borne diseases, food poisoning, and zoonosis risk by raw milk and fresh dairy products. The aim of this work is focused on milk microbial contamination and its impacts on milk production and dairy industry with their implications in milk product quality, food-borne diseases from raw milk, and unpasteurized milk by food-borne pathogen microbial contamination and milk and dairy product spoilage. The microbial milk contamination source comes from herd hygiene and health status, mastitis prevalence, production environment, and milking parlor and milk conserving practices in dairy farm. Moreover, these facts are implicated in milk quality and milk spoilage and unsafe dairy products. The milk production system and the dairy plant operations keep track in pasteurized milk and fresh dairy products reviewing the traceability in field situational diagnosis report.",book:{id:"7943",slug:"nutrition-in-health-and-disease-our-challenges-now-and-forthcoming-time",title:"Nutrition in Health and Disease",fullTitle:"Nutrition in Health and Disease - Our Challenges Now and Forthcoming Time"},signatures:"Valente Velázquez-Ordoñez, Benjamín Valladares-Carranza, Esvieta Tenorio-Borroto, Martín Talavera-Rojas, Jorge Antonio Varela-Guerrero, Jorge Acosta-Dibarrat, Florencia Puigvert, Lucia Grille, Álvaro González Revello and Lucia Pareja",authors:[{id:"15423",title:"Qco.",name:"Lucia",middleName:null,surname:"Pareja",slug:"lucia-pareja",fullName:"Lucia Pareja"},{id:"199849",title:"Dr.",name:"Velazquez",middleName:"Ordoñez",surname:"Valente",slug:"velazquez-valente",fullName:"Velazquez Valente"},{id:"280178",title:"Dr.",name:"Esvieta",middleName:null,surname:"Tenorio-Borroto",slug:"esvieta-tenorio-borroto",fullName:"Esvieta Tenorio-Borroto"},{id:"280179",title:"Dr.",name:"Benjamín",middleName:null,surname:"Valladares-Carranza",slug:"benjamin-valladares-carranza",fullName:"Benjamín Valladares-Carranza"},{id:"280184",title:"Dr.",name:"Jorge",middleName:null,surname:"Acosta-Dibarrat",slug:"jorge-acosta-dibarrat",fullName:"Jorge Acosta-Dibarrat"},{id:"285302",title:"Dr.",name:"Martín",middleName:null,surname:"Talavera Rojas",slug:"martin-talavera-rojas",fullName:"Martín Talavera Rojas"},{id:"285303",title:"Dr.",name:"Lucia",middleName:null,surname:"Grille",slug:"lucia-grille",fullName:"Lucia Grille"},{id:"291633",title:"Dr.",name:"Alvaro",middleName:null,surname:"González Revello",slug:"alvaro-gonzalez-revello",fullName:"Alvaro González Revello"},{id:"301478",title:"Ph.D. Student",name:"Jorge Antonio",middleName:null,surname:"Varela-Guerrero",slug:"jorge-antonio-varela-guerrero",fullName:"Jorge Antonio Varela-Guerrero"},{id:"301479",title:"Ph.D. Student",name:"Florencia",middleName:null,surname:"Puigvert",slug:"florencia-puigvert",fullName:"Florencia Puigvert"}]},{id:"60461",title:"Biological Activities of the Doum Palm (Hyphaene thebaica L.) Extract and Its Bioactive Components",slug:"biological-activities-of-the-doum-palm-hyphaene-thebaica-l-extract-and-its-bioactive-components",totalDownloads:4192,totalCrossrefCites:7,totalDimensionsCites:13,abstract:"The doum palm (Hyphaene thebaica) is a type palm tree which has a wood texture and has edible oval fruits and the origin native to upper Egypt. The trunk of this small palm is dichotomous. It is one of the most important useful plants in the world. All parts of doum palm have a useful role such as fiber and leaflets which used to weave baskets and doum nuts which have antioxidants and secondary metabolites such as tannins, phenols, saponin, steroids, glycosides, flavonoid, terpenes and terpinoids. Also, roots, stems and leaves are used in medicine, ropes and baskets. Studies on anti-inflammatory, antioxidant, antimicrobial, anticancer and pharmacological potential of Hyphaene thebaica extracts and its major phytoconstituents like the phenolic, essential oil and flavonoid compounds are extensively discussed in this review.",book:{id:"6678",slug:"antioxidants-in-foods-and-its-applications",title:"Antioxidants in Foods and Its Applications",fullTitle:"Antioxidants in Foods and Its Applications"},signatures:"Hossam S. El-Beltagi, Heba I. Mohamed, Hany N. Yousef and Eman\nM. Fawzi",authors:[{id:"138817",title:"Dr.",name:"Heba",middleName:null,surname:"Mohamed",slug:"heba-mohamed",fullName:"Heba Mohamed"},{id:"240003",title:"Prof.",name:"Hossam",middleName:"Saad",surname:"El-Beltagi",slug:"hossam-el-beltagi",fullName:"Hossam El-Beltagi"},{id:"251695",title:"Prof.",name:"Eman",middleName:null,surname:"Fawzi",slug:"eman-fawzi",fullName:"Eman Fawzi"},{id:"251950",title:"Dr.",name:"Hany",middleName:null,surname:"Yousef",slug:"hany-yousef",fullName:"Hany Yousef"}]},{id:"71665",title:"Global Prevalence of Malnutrition: Evidence from Literature",slug:"global-prevalence-of-malnutrition-evidence-from-literature",totalDownloads:1991,totalCrossrefCites:4,totalDimensionsCites:12,abstract:"Malnutrition is a widespread problem, affecting the global population at some life stage. This public health epidemic targets everyone, but the most vulnerable groups are poverty-stricken people, young children, adolescents, older people, those who are with illness and have a compromised immune system, as well as lactating and pregnant women. Malnutrition includes both undernutrition (wasting, stunting, underweight, and mineral- and vitamin-related malnutrition) and overnutrition (overweight, obesity, and diet-related noncommunicable diseases). In combating malnutrition, healthcare costs increase, productivity is reduced, and economic growth is staggered, thus perpetuating the cycle of ill health and poverty. The best-targeted age for addressing malnutrition is the first 1000 days of life as this window period is ideal for intervention implementation and tracking for the improvement of child growth and development. There is an unprecedented opportunity to address the various forms of malnutrition, especially the 2016–2025 Decade of Action on Nutrition set by the United Nation. This aims to achieve the relevant targets of the Sustainable Development Goals that aim to end hunger and improve nutrition, as well as promote well-being and ensure healthy lives.",book:{id:"8030",slug:"malnutrition",title:"Malnutrition",fullTitle:"Malnutrition"},signatures:"Natisha Dukhi",authors:[{id:"311182",title:"Dr.",name:"Natisha",middleName:null,surname:"Dukhi",slug:"natisha-dukhi",fullName:"Natisha Dukhi"}]}],onlineFirstChaptersFilter:{topicId:"323",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81528",title:"Effects of High Ambient Temperature on Milk Protein Synthesis in Dairy Cows and Goats: Insights from the Molecular Mechanism Studies",slug:"effects-of-high-ambient-temperature-on-milk-protein-synthesis-in-dairy-cows-and-goats-insights-from-",totalDownloads:14,totalDimensionsCites:0,doi:"10.5772/intechopen.104563",abstract:"Milk protein is well accepted for nutritional value compared with other sources of protein. Detailed understanding of the natural factors that can determine milk protein subcomponent (i.e., casein) not only fulfill the knowledge of protein synthesis but also provide the potential idea to improve milk quality. The variation in milk protein content from dairy cows and goats fed in tropical areas may determine the added value of milk from this region. Under prolonged high ambient temperature (HTa), dairy cows and goats are at the stage of heat stress. This physiological condition produces a negative effect on dairy cows and goats, i.e., food intake and milk yield. However, the higher milk protein content during summer is demonstrated in dairy goats in our condition. Likewise, an increase in heat shock protein 70 (Hsp70) gene expression from mammary epithelium cells isolated from either in vivo (summer and winter periods) and in vitro conditions suggests the direct effect of HTa on mammary gland and perhaps on milk protein synthesis. The intracellular effect of Hsp70 on milk protein synthesis has been proposed in regard to the endoplasmic reticulum and Golgi apparatus protein transportation and with the subcomponent of casein micelle. The present information reveals the molecular mechanism of HTa on milk protein synthesis.",book:{id:"11360",title:"Milk Protein - New Research Approaches",coverURL:"https://cdn.intechopen.com/books/images_new/11360.jpg"},signatures:"Sumpun Thammacharoen, Nungnuch Saipin, Thiet Nguyen and Narongsak Chaiyabutr"},{id:"81333",title:"Pseudocereals: A Novel Path towards Healthy Eating",slug:"pseudocereals-a-novel-path-towards-healthy-eating",totalDownloads:22,totalDimensionsCites:0,doi:"10.5772/intechopen.103708",abstract:"Nowadays, interest in research about pseudocereals has increased worldwide. Pseudocereals can be defined as seeds or fruits of non-grass species that can be consumed similarly to cereals. The most extensively used pseudocereals include quinoa, chia, buckwheat, amaranth, and so on. All of them, have good nutritional and bioactive compounds such as essential amino acids, essential fatty acids, phenolic acids, flavonoids, minerals, and vitamins. Food and Agriculture Organization (FAO) has also reported that there is a buddle of plants that are under-utilized that significantly contribute to improving nutrition and health as well as enhancing food basket and livelihoods of the individual; contributing to future food security and sustainability. Earlier studies also reported that pseudocereals protein-derived peptides have anti-cancerous, anti-inflammatory, anti-hypertensive, hypocholesterolemic, and antioxidant properties. The presence of these interesting properties in pseudocereals enhances the interest to carry out extensive research regarding their health benefits and the way to incorporate them into the diet. In this chapter, we portray different types of pseudocereals with their nutritional benefits for living a healthy and active life.",book:{id:"11354",title:"Pseudocereals",coverURL:"https://cdn.intechopen.com/books/images_new/11354.jpg"},signatures:"Upasana and Latika Yadav"},{id:"80610",title:"Compare the Effects of Ultrasound versus Taping in Lactating Mothers with Breast Engorgement",slug:"compare-the-effects-of-ultrasound-versus-taping-in-lactating-mothers-with-breast-engorgement",totalDownloads:16,totalDimensionsCites:0,doi:"10.5772/intechopen.102359",abstract:"Human milk has hundreds of milk proteins, which provides many benefits on breastfeeding. Breastfeeding is a mother’s gift to herself, her baby, and the earth, there is no substitute for mother’s milk. Milk protein is most important for baby’s growth, development and protects the baby from different illness. Colostrum is produced during early days immediately after child birth, which contains important nutrients and antibodies. Breast engorgement is a problem that is commonly encountered in breastfeeding mothers, which is to be addressed and treated to provide good milk proteins to baby, by relieving discomforts of lactating mothers. A randomized controlled trial was conducted with 30 subjects based on inclusion and exclusion criteria where the subjects are divided into two groups, which contain 15 lactating mothers in each group. The control group that is group-A was treated with ultrasound, and the experimental group that is group-B was treated with ultrasound and Taping Technique. The result of the study showed that there was a significant difference between the pre- and posttest intervention, and we conclude that the ultrasound therapy and Kinesio taping was effective in treating lactating mothers with breast engorgement.",book:{id:"11360",title:"Milk Protein - New Research Approaches",coverURL:"https://cdn.intechopen.com/books/images_new/11360.jpg"},signatures:"Dasarapu Indrani, Jagatheesan Alagesan, Prathap Suganthirababu, M.V. Sowmya and Dubba NagaRaju"},{id:"80780",title:"Omics, the New Technological Approaches to the Milk Protein Researches",slug:"omics-the-new-technological-approaches-to-the-milk-protein-researches",totalDownloads:29,totalDimensionsCites:0,doi:"10.5772/intechopen.102490",abstract:"With the development of technological approaches, the perturbations of biological information in gene, mRNA, proteins, and metabolites have been gathered to broaden the cognition of synthesis processes during lactation. While omics, the series of application including genomics, transcriptomics, proteomics, and metabolomics, are mostly preferred and conducted in the investigation of lactation especially the milk protein. These new technological approaches provide a complete view of the molecular regulation pathways and make it possible to systematically investigate the lactation. The aim of this chapter is to comprehensively review the advances in knowledge regarding the great progress in milk protein synthesis as well as lactation physiology and pathology mainly in dairy cows obtained from omics technologies, meanwhile the milk proteins as well as their attributes are illustrated.",book:{id:"11360",title:"Milk Protein - New Research Approaches",coverURL:"https://cdn.intechopen.com/books/images_new/11360.jpg"},signatures:"Zitai Guo, Lu Ma and Dengpan Bu"},{id:"80943",title:"Colostrum and Milk in Sow",slug:"colostrum-and-milk-in-sow",totalDownloads:34,totalDimensionsCites:0,doi:"10.5772/intechopen.102890",abstract:"Both colostrum and milk quality and quantity can influence piglet survival and growth, especially in a highly prolific sow. The Danish Landrace × Yorkshire crossbred was selected for high prolificacy and challenged to provide enough colostrum and milk of high quality to all piglets. This chapter reviewed the mechanism of colostrum and milk production, basic information of colostrum, and milk quality (immunoglobulin, fat, protein, lactose, etc.) and quantity. The importance of colostrum and milk in modern sows on piglet performance and survival was addressed. Since the sow immunoglobulin cannot pass epitheliochorial placenta in the sow to the piglet’s bloodstream. Therefore, colostrum is a crucial role in piglet survival and growth. However, the amount of colostrum and milk production in hyperprolific sow still improve from high litter size. The knowledge about the factors influencing colostrum and milk quality and quantity, such as parity number, piglet, the environment in hyperprolific sows, may support veterinarians and farmers in the commercial swine farms for increasing pig production. Moreover, the technique to improve colostrum and milk quality and quantity were explained, such as feed supplementation in gestating and lactating sows.",book:{id:"11360",title:"Milk Protein - New Research Approaches",coverURL:"https://cdn.intechopen.com/books/images_new/11360.jpg"},signatures:"Morakot Nuntapaitoon"},{id:"79873",title:"Review on Pseudo-Cereals of India",slug:"review-on-pseudo-cereals-of-india",totalDownloads:30,totalDimensionsCites:0,doi:"10.5772/intechopen.101834",abstract:"Pseudo-cereals are non-grass, wild plants whose seeds are used in the same manner as cereals, but are underutilized due to the dominance of conventional cereal crops. Pseudo-cereals have varied adaptability. They are climatically more resilient and nutritionally richer than major cereal crops. They are enriched with essential amino acids and their protein content is either similar or greater than that of cereals. They contain adequate amounts of dietary fibers that help improve lipid metabolism. They also contain saponins, polyphenols, betalains, flavonoids, antioxidants, vitamins, and other important phytochemical compounds that help detoxify ROS and cope up with the diseases. Interest in the research of pseudo-cereals is growing among the research community due to its extraordinary nutritional and phytochemical profile and its potential in the development of gluten-free products. It can serve as an alternative food source against staple cereal crops under harsh environmental conditions and if cultivated sustainably, can resolve hunger issues in many countries. Pseudo-cereals form an integral part of the biodiversity due to its widespread usage by the tribals. Wild plants of many angiosperm families are used by tribal communities, but in this review, we will only focus on members of Amaranthceae and Chenopodiaceae families.",book:{id:"11354",title:"Pseudocereals",coverURL:"https://cdn.intechopen.com/books/images_new/11354.jpg"},signatures:"Padamnabhi Nagar, Riya Engineer and Krishna Rajput"}],onlineFirstChaptersTotal:15},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:99,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:290,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:12,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"May 18th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",isOpenForSubmission:!0,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. His research interests include optimization, computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, and intelligent systems. Prof. Sarfraz has been a keynote/invited speaker at various platforms around the globe. He has advised/supervised more than 110 students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He has authored and/or edited around seventy books. Prof. Sarfraz is a member of various professional societies. He is a chair and member of international advisory committees and organizing committees of numerous international conferences. He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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Among them are those associated with pollution, resource extraction and overexploitation, loss of biodiversity, soil degradation, disorderly land occupation and planning, and many others. These anthropic effects could potentially be caused by any inadequate management of the environment. However, ecosystems have a resilience that makes them react to disturbances which mitigate the negative effects. It is critical to understand how ecosystems, natural and anthropized, including urban environments, respond to actions that have a negative influence and how they are managed. It is also important to establish when the limits marked by the resilience and the breaking point are achieved and when no return is possible. 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This includes, but is not limited to: single-neuron modeling, sensory processing, motor control, memory, and synaptic plasticity, attention, identification, categorization, discrimination, learning, development, axonal patterning, guidance, neural architecture, behaviors, and dynamics of networks, cognition and the neuroscientific basis of consciousness. Particularly interesting are models of various types of more compound functions and abilities, various and more general fundamental principles (e.g., regarding architecture, organization, learning, development, etc.) found at various spatial and temporal levels.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",keywords:"Single-Neuron Modeling, Sensory Processing, Motor Control, Memory and Synaptic Pasticity, Attention, Identification, Categorization, Discrimination, Learning, Development, Axonal Patterning and Guidance, Neural Architecture, Behaviours and Dynamics of Networks, Cognition and the Neuroscientific Basis of Consciousness"},{id:"24",title:"Computer Vision",scope:"The scope of this topic is to disseminate the recent advances in the rapidly growing field of computer vision from both the theoretical and practical points of view. 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Moreover, in the field of machine learning, evolutionary computation has carved out a significant niche both in the generation of learning models and in the automatic design and optimization of hyperparameters in deep learning models. This collection aims to include quality volumes on various topics related to evolutionary algorithms and, alternatively, other metaheuristics of interest inspired by nature. For example, some of the issues of interest could be the following: Advances in evolutionary computation (Genetic algorithms, Genetic programming, Bio-inspired metaheuristics, Hybrid metaheuristics, Parallel ECs); Applications of evolutionary algorithms (Machine learning and Data Mining with EAs, Search-Based Software Engineering, Scheduling, and Planning Applications, Smart Transport Applications, Applications to Games, Image Analysis, Signal Processing and Pattern Recognition, Applications to Sustainability).",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",keywords:"Genetic Algorithms, Genetic Programming, Evolutionary Programming, Evolution Strategies, Hybrid Algorithms, Bioinspired Metaheuristics, Ant Colony Optimization, Evolutionary Learning, Hyperparameter Optimization"},{id:"26",title:"Machine Learning and Data Mining",scope:"The scope of machine learning and data mining is immense and is growing every day. It has become a massive part of our daily lives, making predictions based on experience, making this a fascinating area that solves problems that otherwise would not be possible or easy to solve. This topic aims to encompass algorithms that learn from experience (supervised and unsupervised), improve their performance over time and enable machines to make data-driven decisions. It is not limited to any particular applications, but contributions are encouraged from all disciplines.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",keywords:"Intelligent Systems, Machine Learning, Data Science, Data Mining, Artificial Intelligence"},{id:"27",title:"Multi-Agent Systems",scope:"Multi-agent systems are recognised as a state of the art field in Artificial Intelligence studies, which is popular due to the usefulness in facilitation capabilities to handle real-world problem-solving in a distributed fashion. The area covers many techniques that offer solutions to emerging problems in robotics and enterprise-level software systems. Collaborative intelligence is highly and effectively achieved with multi-agent systems. Areas of application include swarms of robots, flocks of UAVs, collaborative software management. Given the level of technological enhancements, the popularity of machine learning in use has opened a new chapter in multi-agent studies alongside the practical challenges and long-lasting collaboration issues in the field. It has increased the urgency and the need for further studies in this field. We welcome chapters presenting research on the many applications of multi-agent studies including, but not limited to, the following key areas: machine learning for multi-agent systems; modeling swarms robots and flocks of UAVs with multi-agent systems; decision science and multi-agent systems; software engineering for and with multi-agent systems; tools and technologies of multi-agent systems.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",keywords:"Collaborative Intelligence, Learning, Distributed Control System, Swarm Robotics, Decision Science, Software Engineering"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"25",title:"Environmental Sciences",doi:"10.5772/intechopen.100362",issn:"2754-6713",scope:"\r\n\tScientists have long researched to understand the environment and man’s place in it. The search for this knowledge grows in importance as rapid increases in population and economic development intensify humans’ stresses on ecosystems. Fortunately, rapid increases in multiple scientific areas are advancing our understanding of environmental sciences. Breakthroughs in computing, molecular biology, ecology, and sustainability science are enhancing our ability to utilize environmental sciences to address real-world problems.
\r\n\tThe four topics of this book series - Pollution; Environmental Resilience and Management; Ecosystems and Biodiversity; and Water Science - will address important areas of advancement in the environmental sciences. They will represent an excellent initial grouping of published works on these critical topics.
\r\n\tPollution is caused by a wide variety of human activities and occurs in diverse forms, for example biological, chemical, et cetera. In recent years, significant efforts have been made to ensure that the environment is clean, that rigorous rules are implemented, and old laws are updated to reduce the risks towards humans and ecosystems. However, rapid industrialization and the need for more cultivable sources or habitable lands, for an increasing population, as well as fewer alternatives for waste disposal, make the pollution control tasks more challenging. Therefore, this topic will focus on assessing and managing environmental pollution. It will cover various subjects, including risk assessment due to the pollution of ecosystems, transport and fate of pollutants, restoration or remediation of polluted matrices, and efforts towards sustainable solutions to minimize environmental pollution.
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",annualVolume:11967,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/39.jpg",editor:{id:"137040",title:"Prof.",name:"Jose",middleName:null,surname:"Navarro-Pedreño",fullName:"Jose Navarro-Pedreño",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRAXrQAO/Profile_Picture_2022-03-09T15:50:19.jpg",institutionString:"Miguel Hernández University of Elche, Spain",institution:null},editorTwo:null,editorThree:null,editorialBoard:[{id:"177015",title:"Prof.",name:"Elke Jurandy",middleName:null,surname:"Bran Nogueira Cardoso",fullName:"Elke Jurandy Bran Nogueira Cardoso",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRGxzQAG/Profile_Picture_2022-03-25T08:32:33.jpg",institutionString:"Universidade de São Paulo, Brazil",institution:null},{id:"211260",title:"Dr.",name:"Sandra",middleName:null,surname:"Ricart",fullName:"Sandra Ricart",profilePictureURL:"https://mts.intechopen.com/storage/users/211260/images/system/211260.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}}]},{id:"40",title:"Ecosystems and Biodiversity",keywords:"Ecosystems, Biodiversity, Fauna, Taxonomy, Invasive species, Destruction of habitats, Overexploitation of natural resources, Pollution, Global warming, Conservation of natural spaces, Bioremediation",scope:"