FL rulebase for linear varying sliding surface.
\r\n\t
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In VS, image plane is used to define these
Studies on IBVS mostly focus on different feature extraction methods [4], different camera geometries and types [5], hybrid VS methods [6] or other problems of VS like singularity avoidance or field of view (FOV) keeping [7] but the controller design doesn\'t draw too much attention because the linear velocity controller design approach of VS is assumed as the sufficient controller as the errors are decreasing exponentially. Besides this common sense, other performance parameters like convergence time, velocity limits, and error magnitudes are actually real‐time metrics. For robot applications in a production line, these parameters become dominant to speed up process to increase accuracy and repeatability. Some other control approaches like visual predictive control [8] fusing predictive control with VS are promising but the controller should be applicable in real‐time.
\nTo design a new IBVS controller, the velocity controller design approach of IBVS should be examined. As explained in details in the following section, the linear controller of IBVS is using sliding surface design of sliding mode control (SMC). In SMC, two design steps are defined. The first one is designing a sliding surface that represent desired stable states of the system, and the second one is designing a control law that guarantee states reaching to the sliding surface and sliding on this surface [9]. A sliding slope is defined in SMC and this slope is named as gain in IBVS. The rule of thumb of an appropriate slope in SMC is choosing a slope small enough in order not to exceed control limits and conversely, choosing a slope big enough to reach the sliding slope faster and slide on this surface faster. This is interpreted by IBVS as choosing gain small enough in order not to exceed velocity limits and choosing gain big enough to converge faster.
\nFrom initial conditions to convergence, there are two modes of state trajectories in SMC. In reaching mode, the states are not on the sliding surface and they try to reach this surface. In sliding mode, they are on the sliding surface and they try to converge to zero. IBVS and SMC uses fixed gain‐sliding slope but alternatively, in the literature, there are many different sliding surface designs which are important from the practical point of view and for high performance. Two main approaches are mentioned in the literature of sliding surface design: linear and nonlinear [10]. Although there are numerous designs for linear surfaces, it is very hard to obtain a nonlinear surface using linear surfaces for high performance, and it is hard to define the parameters of these designs. There are not too many options and the parameters are easily defined for nonlinear designs, but the magnitude of control signals should be observed to avoid saturation [10, 11]. The titles of the most common linear designs are linear constant surface [9], integral sliding surface [12], linear varying (rotating and shifting) sliding surface [13], and linear time‐varying sliding surface [14] designs. Nonlinear designs are more popular and titled as constant nonlinear sliding surface [15], higher order sliding surface [16], fractional sliding surface [17], terminal sliding surface [18], nonlinear sliding surface with nonlinear functions [19], and nonlinear moving sliding and terminal sliding surface designs [14]. Furthermore, intelligent methods like fuzzy logic (FL) and genetic algorithms (GA) are also deployed for parameter assignment of linear and nonlinear surface designs [20]. Detailed reviews on sliding surface designs can be found in [11, 14, 20].
\nMost studies on VS focus on image processing‐feature extraction part of vision, but control part is still open to old and new approaches. In this study, five different sliding surface designs with analytical and intelligent methods are modified and applied to an IBVS system to expand these designs to visually guided robot manipulators. The design methods are selected according to their relevance and applicability to these manipulator systems. In the first design, linear varying sliding surface with FL is assumed. Error and error derivative are used as inputs of FL and to define linguistic rules of FL, the effects of gain on IBVS and experience on IBVS are used. In the second design, integral sliding mode is assumed and the sliding parameter of integral term is tuned using FL. In the third design, time‐optimal varying sliding surface design with constant acceleration is assumed. A time interval is defined for this design and linear sliding mode is modified according to this time interval. In the fourth design, a nonlinear tangent hyperbolic function with a width parameter function is used to define a sliding surface. In the fifth design, nonlinear time‐varying sliding surface is assumed. The surface is obtained by the product of initial error‐error derivatives and an exponential time‐varying term. To show the performance of these designs, an error cost function is defined as in [19]. An IBVS system with six‐DOF manipulator is simulated and the designs are tested on this system. A comparison of these design methods according to convergence time, error cost function, defined parameters, and motion characteristics is given.
\nThe paper is organized as follows. In the following section, IBVS and used sliding surface designs with modifications and adaptations to IBVS are explained briefly. In Section 3, simulation results for classical IBVS and IBVS with five sliding surface designs are shown. In the last section, an overall comparison of these designs is given and conclusions of the study and future goals are discussed.
\nIn this section, a review on IBVS and sliding surface designs used in the study is given. The main objective of IBVS, as all VS approaches, is to minimize errors derived from
where
In the classical IBVS, a point
This velocity is used to obtain transformation between the velocity of the coordinates of perspective projection point (
where
By using (1) and (3), relation between error and velocity is obtained as
IBVS tries to decrease the error exponentially by using the differential equation
From another aspect, this differential equation is the main equation used by classical SMC to define a sliding surface. Classical SMC defines a surface in terms of error and error derivatives according to the system degree and tries to hold the system states in this surface by equalizing this surface to zero. This definition strongly connects SMC and IBVS. IBVS proposes a kinematic velocity controller and the velocity signals are the control signals. Again, by using (4) and (5), velocity signals is defined as
where,
Varying sliding slope is a common approach in sliding surface designs to achieve desired performance without exceeding velocity limits. The only design parameter in (5) and (6) is the sliding slope, and an on‐line parameter tuning algorithm can be proposed by using varying sliding slope approach. Instead of an analytical approach which proposes different parameters to tune a parameter, and which has to be tuned carefully to allow soft parameter variation, FL can be a good candidate not only to avoid tuning twice but also to include linguistic definitions and user experience in the design [21]. IBVS velocity controller in (6) can be modified as in (7) and the block diagram of IBVS with linear varying sliding surface design using fuzzy logic is shown in Figure 1.
IBVS with linear varying sliding surface design using fuzzy logic.
In Figure 1, it must be noted that limiters should be placed before FL block to restrict
The classical linear sliding surface design in (5) is a PD‐type sliding surface and an integral term can be added to this design to increase tracking performance [12, 22]. This term can be active for all error trajectories or only when the errors are in predefined bounds. Integral sliding surface is given below:
Finding appropriate gain values
IBVS with integral surface design using fuzzy logic.
As mentioned in [14], trade‐off between short sliding slope reaching phase and slower responses in sliding surfaces can be bested by time‐varying sliding slopes. A time‐varying sliding slope term, which is defined as a function of time is added to classical sliding surface design and this term is only active until a predefined time instant. In his study, Bartoszewicz designed two different time‐varying sliding surfaces, constant‐acceleration, and constant‐velocity, according to time dependence [14]. Constant‐acceleration time‐varying sliding surface offers a faster convergence speed to classical sliding surface and this design is chosen in this study. Constant‐acceleration time‐varying sliding surface design is given in (11) and definitions for the design parameters are given in (12), respectively
where
The velocity controller and the block diagram of IBVS with time‐varying sliding surface design is shown in (13) and Figure 3 with sample/hold (S/H) units, respectively
IBVS with time‐varying sliding surface design with constant acceleration.
Sliding surfaces in the first three designs are linear, which means that error and error derivative will pursue a constant sliding slope. In fact, linear varying or time‐varying sliding surfaces reveals piecewise linear surfaces. Instead of using these linear methods, a nonlinear function can be assigned as a sliding surface function [15]. Tangent hyperbolic function can be a good candidate as a nonlinear function [11] and it is preferred in this study. The definition of nonlinear sliding surface design with tangent hyperbolic function is given in (14)
where
IBVS with nonlinear sliding surface design using tangent hyperbolic function.
As an alternative to nonlinear constant functions, nonlinear time‐varying surfaces can be designed to shorten reaching phase. Exponential time‐varying functions [14, 19, 24, 25] are proposed in the literature as nonlinear time‐varying sliding surface functions. In this study, exponential nonlinear time‐varying sliding surface design in (19) is chosen and it is given in (16)
where
IBVS with nonlinear time‐varying sliding surface design.
In this study, an IBVS system with intelligent sliding surfaces is simulated using MATLAB
Some assumptions in the study should be given before simulation results:
\nThe camera parameters are defined as follows: the resolution of the camera is 1024×1024, the principal point is (512, 512), and the focal length is 8 mm. The feature points in Cartesian coordinates are defined as
The estimated depth value for
The block diagram of the simulated IBVS systems with sliding surface design.
The
The desired pose of Puma 560 with
The main performance criterions for an IBVS system are convergence time
where
To make a comparison between each design, a classical IBVS system with fixed sliding slope is assumed as in (5) and (6). The fixed value for
The
The feature motions in image plane are shown in Figure 10.a with initial feature points in red circles and target feature points in blue circles. The velocity signals of the end effector are shown in Figure 10.b, and the error signals are shown in Figure 10.c, respectively.
\nThe results for Case 1. (a) Feature motions in image plane (b) Velocities of the end effector (c) Feature errors (d) Error vs. error derivative trajectory.
As shown in Figure 10.a‐b, the paths of the feature points are linear and the errors are exponentially decreasing as expected from classical IBVS [1]. As the convergence time, the time instant when all absolute errors decreases under 1 pixel is assumed and it is 12.89 s as shown in Figure 10.c. The error cost for Case 1 is 2482. As an example of fixed sliding slope, error and error derivative trajectory
The choice of an appropriate
IBVS derives different error signals for each feature. FL needs error and error derivative for an appropriate
The
The type of FL unit is Mamdani and the membership functions of the error, the error derivative norm inputs and output
FL membership functions for
FL surface for
The results for Case 2. (a) Feature motions (b) Velocities of the end effector (c) Feature errors (d)
Low | \nMedium | \nHigh | \n|
---|---|---|---|
High | \nHigh | \nHigh | \n|
High | \nMedium | \nLow | \n|
Low | \nLow | \nLow | \n
FL rulebase for linear varying sliding surface.
The feature motions in image plane are shown in Figure 14.a, the velocity signals of the end effector are shown in Figure 14.b, and the error signals are shown in Figure 14.c, respectively.
\nThe varying sliding slope
The velocity profiles dwell in velocity limits and increases after 3.98 s as shown in Figure 14.b. The errors decreases rapidly after varying sliding slope as shown in Figure 14.c and error and error derivative try to follow varying sliding slope after 3.98 s. The convergence time is 7.35 s and the error cost is 2591 for Case 2. In Figure 14.a, it can be seen that the feature motions are linear, which means that this sliding approach doesn\'t affect motion characteristics of IBVS.
\nIBVS with integral sliding surface in (10) is assumed as Case 3 and
The
FL unit uses error as input, two membership functions are defined for this input and the FL surface curve is shown in Figure 16. Here, it must be noted that limits of this curve, thus
FL surface curve for
The feature motions in image plane are shown in Figure 17.a, and the velocity signals of the end effector are shown in Figure 17.b, respectively. The error signals and the error integral term signals after
The results for Case 3. (a) Feature motions (b) Velocities of the end effector (c) Feature errors (d) Error integral term.
In his study, Bartoszewicz proposed a time‐optimal sliding mode approach for robust control of second‐order uncertain systems [14]. Time‐optimality needs time‐varying sliding slopes to adapt the system to initial conditions. These initial conditions for an IBVS system are dominant if they are far from zero.
The
The feature motions in image plane are shown in Figure 19.a, the velocity signals of the end effector are shown in Figure 19.b, the error signals are shown in Figure 19.c, and time dependent terms in (13) are shown in 19.d, respectively.
\nThe results for Case 4. (a) Feature motions (b) Velocities of the end effector (c) Feature errors (d) Time dependent terms in (13).
The feature motion trajectories in the previous cases are quite similar but in this case, the motions are curvilinear as shown in Figure 19.a. This is the consequence of time dependent terms shown in Figure 19.d. They are the sum of the terms in (13) and they drag the motions throughout target features until the end of time dependence.
Tangent hyperbolic function is chosen as nonlinear sliding surface function and the magnitude and slope of this function is also dependent on error and constant
Here, wp can be defined as a function of time as in (11) but it is chosen as a function of error in this study. Inside the
The
The feature motions in image plane are shown in Figure 21.a, the velocity signals of the end effector are shown in Figure 21.b, and the error signals are shown in Figure 21.c, respectively. To show the nonlinear sliding surface, error and error derivative trajectories for the first feature in
The results for Case 5. (a) Feature motions (b) Velocities of the end effector (c) Feature errors (d) Error vs. error derivative trajectory.
Unlike the first four cases, the initial velocity values are quite small as shown in Figure 21.b and that can be a big positive in the realization of an IBVS system as mentioned in [29]. The feature motions are slightly curvilinear as shown in Figure 21.a. The convergence time is 10.85 s and the error cost is 4094 for Case 5. Error vs. error derivative trajectory follows tangent hyperbolic function as shown in Figure 21.d.
\nExponential nonlinear time‐varying sliding surface in (17) also utilizes initial error and error derivative values.
The feature motions in image plane are shown in Figure 23.a, the velocity signals of the end effector are shown in Figure 23.b, and the error signals are shown in Figure 23.c, respectively.
\nThe
The results for Case 6. (a) Feature motions (b) Velocities of the end effector (c) Feature errors (d) Nonlinear term of each velocity.
Nonlinear term of each velocity in (17) with 5 s transient is shown in Figure 23.d. After this transient, the system behaves like classical IBVS system. The motions are curvilinear as shown in Figure 23.a. The convergence time is 12.12 s and the error cost is 2795 for Case 6.
\nAs a new field of control systems, most studies on VS focus on image processing or pattern recognition parts of the applications. The controller part has still gaps. On the other hand, SMC is a convenient control method for linear and nonlinear systems, and it is based on the design of sliding surfaces. In this study, five different sliding surface designs including analytical and intelligent methods are modified and applied to an IBVS manipulator system to adapt the designs and to compare the performance of these designs. The design methods are selected according to their relevance and applicability to this type of visually guided manipulator systems.
\nSliding surface design is the first step of SMC and the designer has to consider robustness and transient behaviour of the system. When these designs are considered for an IBVS system, the designer has to deal not only with these issues but also the velocity limits, the convergence time, and motion characteristics. Furthermore, the designer must have experience on sliding surface design to tune the design parameters appropriately. In this study, these hotspots are considered. In the simulations, a random noise is added to each feature point to show the robustness of the designs. According to IBVS metrics mentioned above, a comparison of design methods used in the study is given in Table 2.
\nDesign | \nConvergence time (s) | \nError cost | \nParameters | \nMotion characteristic | \n
---|---|---|---|---|
Classical IBVS with fixed sliding slope | \n12.89 | \n2842 | \n||
IBVS with linear varying sliding surface using fuzzy logic | \n2591 | \n|||
IBVS with integral sliding surface using fuzzy logic | \n9.41 | \n|||
IBVS with time‐varying sliding surface design and constant acceleration | \n11.82 | \n2891 | \nCurvilinear | \n|
IBVS with nonlinear sliding surface design using tangent hyperbolic function | \n10.85 | \n4094 | \n(function), | \nCurvilinear | \n
IBVS with nonlinear time‐varying sliding surface | \n12.12 | \n2795 | \nCurvilinear | \n
Comparison of sliding surface designs in the study.
All designs in the study considered angular and linear velocity limits which are the most restrictive quantity of a manipulator system, and these limits also form a homogenous basis for comparison. In Table 2, it can be seen that IBVS with linear varying sliding surface using fuzzy logic is the fastest design according to convergence time. It can be concluded that changing sliding slope using FL with error and error derivative inputs results fast response with low velocity profiles. Nonetheless, the only parameter which has to be tuned in this design is not a parameter but an FL unit. As an intelligent method, FL utilizes user or designer experience and the designer has to be careful when using FL in order not to miss a rule. Compared to classical IBVS with fixed sliding slope, all design methods in the study decreases convergence time.
\nIBVS with integral sliding surface using fuzzy logic has the lowest error cost, but it must be noted that the integral term should be used wisely against wind‐up conditions.
\nThree designs have linear motion characteristics and as mentioned in [1], it is important for keeping FOV. When the other designs with curvilinear characteristics are needed for a VS realization, additional methods should be used to avoid this drawback.
\nParameter tuning of each design is another issue binding the theory with user experience. FL units in these designs directly need user experience. In the future studies, intelligent hybrid units which doesn\'t need user experience like ANFIS will be used.
\nIn the future studies, the main goal will be the realization of these designs in real IBVS manipulator system. Furthermore, not only kinematics of the manipulator, but also the dynamics and inner loop control of the manipulator will be added to the realization.
\nResearch was initiated in the early 1990s which led in 2000 to the publication of the technology behind what came to be known as Golden Rice [1, 2]. From the outset, the intention was to create a source of vitamin A in the endosperm of rice, as an additional intervention for vitamin A deficiency. Philanthropy and the public sector funded the research [1]. In 2001, the inventors, Professor Ingo Potrykus and Dr. (now Professor) Peter Beyer, assigned their patents to Syngenta for commercial exploitation as part of a transaction which obliged the company to assist the inventors’ humanitarian and altruistic objectives [1, 3, 4]. At the same time, the nutritional technology was donated by its inventors for use in developing countries [3, 4]. The inventors licenced a network of Asian government-owned rice research institutes to deliver their objectives. Product development was initiated through the International Rice Research Institute (IRRI) and the network. The whole network, including IRRI, worked to a common set of goals defined in licences each institution signed with the inventors. The terms included that there would be no charge for the nutritional technology and it would only be introduced to publicly owned rice varieties. Improvements were made to the technology by Syngenta scientists [5]. In 2005 and 2006, pursuant to Syngenta’s legal obligations entered into with the inventors in 2001, Syngenta provided selected transformation events of the improvements to the Golden Rice Humanitarian Board. The Humanitarian Board, via Syngenta and IRRI, made these new versions available to the Golden Rice licensee network [4, 6]. In 2004 Syngenta ceased its commercial interest in Golden Rice [7]. From 2004 development was again only funded by philanthropy and the public sector; the national budgets of Bangladesh, China, India, Indonesia, Philippines and Vietnam; as well as the US National Institutes of Health together with the Rockefeller and Bill & Melinda Gates Foundations and USAID. Golden Rice is a not-for-profit project: no individual, nor organisation involved with its development, has any financial interest in the outcome.
To date the Golden Rice project has principally engaged plant scientists. Activist opposition to Golden Rice has been led principally by non-scientists, who have been very successful in developing a narrative about Golden Rice and gmo crops which serves the activist’s purpose1 but is fundamentally inaccurate [8]. Further background to the development of Golden Rice, including the political dimensions, is detailed elsewhere [6, 9, 10].
A few years ago, at Tufts University, USA, I gave a presentation about Golden Rice. The symposium was organised by the Friedman School of Nutrition Science and Policy whose strategic aims today include ‘Reduce nutrition-related health inequities’ and ‘Promote food systems that increase agricultural sustainability while improving human health’ [11]. I was dismayed to learn that the anti-gmo and anti-Golden Rice activists’ narrative was widely accepted by the participants—all of whom were studying or working in nutrition and well aware of nutritional inequities in public health.
Without adoption, that is, regular growth and consumption of Golden Rice by populations in countries where rice is the staple and VAD is problematic, Golden Rice cannot deliver any public health and welfare benefits. Adoption requires cooperative working by different specialists, including medical, nutritional and public health specialists [12]. This chapter is designed to answer anticipated questions from such specialists, to facilitate adoption of Golden Rice as an additional intervention for vitamin A deficiency.
Rice is the most important staple crop [6]: more than half of the global population eats it every day. In some countries, 70–80% of an individual’s calorie intake is from consumption of rice [13, 14].
For storage without becoming rancid, the husk and the aleurone layer of rice have to be removed. What remains after polishing-white rice, the endosperm-contains small amounts of fat and is an excellent source of carbohydrate for energy but contains no micronutrients. Yet humans require both macronutrients (carbohydrates, proteins, fats) and micronutrients (minerals and vitamins) for a healthy life. Like all plants, rice obtains its minerals from the soil. Vitamins are synthesised by plants and/or animals, including humans.
Human health is best served by a ‘balanced diet’ that is varied, containing both macronutrients and micronutrients, including animal products and, as sources of provitamin A, coloured fruits and vegetables. Micronutrient sources are insufficiently represented in the diets of many people in countries where rice is the staple. The reasons often include poverty: such dietary components are expensive compared to the cost of rice [15]. In countries where rice is the staple, the average consumption is 75.20 kg/capita/year. Of those countries where micronutrient deficiencies are common, consumption increases to 150 kg/capita/year [16]. In such populations micronutrient deficiencies, like poverty itself, often occur as part of an intergenerational cycle [17].
For the past 15 years, 800 million people—more than 10% of the global population—are hungry every day. These chronically hungry individuals lack sufficient calories in their daily diet [18, 19, 20]; indeed over the past 3 years, the trend is upward [20]. Even more alarming is that 2 billion people—almost 25% of global population—are micronutrient deficient; they suffer from ‘hidden hunger’, with important associated morbidity and mortality [17] and related economic impact [6, 17]. Figure 1 shows that over the 20-year period 1990–2010, the rate of reduction of chronic hunger (that is, macronutrient—carbohydrate, proteins and fats—dietary insufficiency) has been faster than the rate of reduction for hidden hunger (that is, dietary insufficiency of minerals and vitamins) [21] Dr. Matin Qaim, member of the Golden Rice Humanitarian Board and one of the authors of the paper from which Figure 1 is extracted, has commented: ‘In the future the hidden hunger [e.g. micronutrient deficiency] burden will be larger, [than chronic hunger – principally carbohydrate deficiency] unless targeted efforts to reduce micronutrient malnutrition are implemented at larger scale’ (pers comm: Dr. M Qaim).
Disability-adjusted life years (DALYs) lost due to chronic hunger and hidden hunger between 1990 and 2010. Please refer to text for further explanation (
Interventions for micronutrient deficiencies include
With the creation of Golden Rice in 1999 [2]—the first purposefully created biofortified crop—a new term was required: ‘biofortification’. The word was first used in 2002 [23] and first defined in 2004 [24]: “biofortification” is a word coined to refer to increasing the bioavailable micronutrient content of food crops through genetic selection via plant breeding.’ In 2003 ‘Harvest Plus’ a not-for-profit public-sector programme started to biofortify staple crops by conventional plant breeding, to benefit the poor, and progress with biofortification through conventional plant breeding was rewarded by the World Food Prize in 2016 [25].
The intention of biofortification is to deliver public health benefits to populations which are micronutrient deficient, through consumption of the staple crop including the extra nutrition within the edible part of the crop. In this way minimal cultural change is required to food—production, processing or consumption—systems. For the most marginal members of the population, this biofortification approach overcomes the inherent access, cost and non-sustainability difficulties of supplementation and fortification. In 2017 the World Bank recommended that biofortified staple crops should be the norm rather than the exception: ‘conventionally’ bred biofortified crops and also genetically engineered crops—gmo crops—were both recommended with Golden Rice specifically mentioned [26].
For Golden Rice to deliver benefits, it has to be grown and consumed within target countries where VAD remains problematic despite significant progress with other interventions, notably vitamin A capsules, which have undoubtedly saved millions of lives and will save more, since they were introduced (accompanied by controversy) in the 1990s [15, 22]. And success or failure with Golden Rice will directly affect future adoption also of high zinc, high iron and high folate rice and their impact on public health for hundreds of millions of people. All these traits, introduced to the endosperm of rice, necessitated using gmo techniques [16, 27], and all cost no more than white rice to the grower or consumer. Eventually, as the end point of product development, it is planned to include all these nutritional traits together in multi-micronutrient-Golden Rice.
Adoption of Golden Rice requires public health professionals as well as agricultural and other professionals, to work together in each country [12]. Any scepticism created by the past 18 years of negative activist influence will prevent success, if not positively addressed by all involved. For billions of people, the stakes could not be higher.
For more than a quarter of a century, vitamin A deficiency (VAD) has been recognised by the United Nations as a significant public health problem. Key milestones included the:
VAD control is the most cost-effective child health/survival strategy governments can pursue.
All sectors of society should support the virtual elimination of VAD.
Strategies should include promoting breast-feeding, dietary diversification, vitamin A supplementation and food fortification.
Locally available food-based strategies are the first priority. Vitamin A capsule supplementation is only an interim measure [29].
Nevertheless, vitamin A deficiency (VAD) remains a major public health problem, in more than half of all countries, especially in Africa and south-east Asia (Figure 2), hitting hardest young children and pregnant women [31] especially in countries where rice is the staple food. Food sources that are most valuable in terms of micronutrients—for vitamin A, animal products including milk, eggs, butter, liver and fish—are usually more expensive and ‘beyond the reach of poor families’ [15]. Food security staple crops such as rice are cheaper and therefore make up most of the diet.
Public health importance for vitamin A deficiency, by country. Source [
The problem of VAD is exacerbated by the limited bioavailability of vitamin A from fruit and vegetables [33]. It has been estimated that young children between ages 1 and 3 years would need to eat eight servings of dark green leafy vegetables per day in order to meet the recommended dietary allowance (‘RDA’) for vitamin A. These facts have resulted in the conclusion of ‘the virtual impossibility for most poor, young children to meet their vitamin A requirements through vegetable and fruit intake alone’ [15].
VAD is the principal cause of irreversible blindness in children [34]. Another morbidity of VAD is related to impairment of the immune system [15]: most children and mothers who die as a result of VAD do not become blind first but die of common childhood diseases. VAD is a
Global mortality (millions) | 2010a | 2014a | 2016/2017 |
---|---|---|---|
Vitamin A deficiency | 1.9–2.8 | 1.4–2.1 | 1.3–1.9 (2016)b |
HIV/AIDS | 1.8 | 1.2 | 0.94 (2017)c |
Tuberculosis (TB) | 1.4 | 1.1 | 1.6 (2017)d |
Malaria | 0.7 | 0.6 | 0.45 (2016)e |
Annual mortality from different public health diseases (VAD deaths exclude significant maternal mortality).
Source: [6]
Source: 23–34%—see text—of 5.6 months <5 years children in 2016 [37]
Source: http://www.unaids.org/en/resources/fact-sheet [Accessed: January 10, 2019]
Source: https://www.who.int/news-room/fact-sheets/detail/tuberculosis [Accessed: January 10, 2019]
Source: https://reliefweb.int/report/world/world-malaria-report-2017 [Accessed: January 10, 2019]
In 2016, 26 years after the first UN commitment to
There is not one type of Golden Rice. The ‘genetic modification’ part of the process used to create Golden Rice occurred only once, in about 2004 [5]. The preferred ‘transformation event GR2E’ was selected in late 2013 [6, 9] and subsequently introduced by ‘conventional plant breeding’ into more than a dozen cultivars of the
The agronomy of Golden Rice—how it grows, its resistance to pests and diseases, its water requirements and days to maturity and plant and grain morphologies—and yield are the same as the variety into which the nutritional trait has been introduced. An avoidable human error was made in an earlier selection of ‘a lead transformation event: GR2R’, which led to plants in open fields falling over when subject to wind and rain, and a small yield loss of about 2% was the result [9, 38]. GR2R was dropped from development in late 2013. The current lead transformation event, GR2E, was selected in the same year. GR2E has been, and will be, registered for use and has no problems associated with it [6].
In his wonderful book
Nevertheless, for Golden Rice ‘from a public health standpoint, for food fortification to be effective’, all the characteristics listed by Dr. Semba are satisfied, except when it comes to ‘undetectable by persons consuming it’. The Golden Rice colour is caused by the β-carotene content, a source of vitamin A for humans, which in Golden Rice is about 80–90% of all carotenoids [5]. It is the same β-carotene which colours mangos, papaya, squash and carrots, all of which consumers readily accept, and there is no taste associated with the β-carotene content. In Golden Rice, the intensity of the colour is proportional to the β-carotene content. The colour is obvious and cannot be ignored (Figure 3).
Polished white and Golden Rice and (a different cultivar, after 2 months of postharvest storage) after cooking.
In 2009 MBA students at the Asian Institute of Management conducted qualitative attitudinal surveys of small farmers and consumers in four different representative island locations in the Philippines. Neither the colour nor the way it was created was considered a block to trying Golden Rice, so long as it was expected to assist their family’s health and was affordable. The solid colour of Golden Rice was recognisably distinct from the rather blotchy yellow colour of poorly stored white rice, which is sometimes offered cheaply by governments to assist poor people.
From several perspectives the colour of Golden Rice is positive. Consumers have a choice about whether to select it for cooking and whether to consume it or not. Such consumer choice is denied and therefore only made by governments or plant breeders, when the biofortified trait is ‘undetectable by persons consuming it’ [15], as in the case of invisible biofortificants such as iron or zinc introduced into biofortified grain crops or used in fortification of processed food. The colour of Golden Rice makes the consumers’ choice clear, even in populations with a variety of languages and dialects or where individuals are illiterate: each grain of Golden Rice is individually labelled, by its colour. No labelling is required on any packaging, and preference can be beneficially affected by communication of its lack of any adverse associations, and anticipated health benefits, from consumption.
Eighty percent—about 380 million tonnes—of global rice production is produced on small farms for family consumption, usually unprocessed except for polishing [38]. It is probably not stored for long, as rice is produced, usually, in two or three growth cycles annually, and storage facilities are limited. Data have shown that degradation of the β-carotene is minimal 2 months after harvest and samples of Golden Rice stored in ambient temperatures for 4.5 years remain noticeably yellow, indicating continued presence of β-carotene [39].
In early 2001, a year after the seminal paper describing the ‘proof of concept’ technology [2], Greenpeace made a press release: ‘Genetically modified “Golden Rice” containing provitamin A will not solve the problem of malnutrition in developing countries,… Greenpeace calculations show… , that an adult would have to eat at least 3.7 kilos of dry weight rice, i.e. around 9 kilos of cooked rice, to satisfy their daily need of vitamin A from “Golden Rice” …’ [40].
It is unclear how Greenpeace came to their conclusion. At the time, it was known that the bioavailability of carotenoids is influenced by nine different factors [41]. But no one knew how efficiently the β-carotene in Golden Rice was converted to circulating vitamin A, retinol, by human adults or children. And nutritionists agreed that animal models would not be helpful because animals metabolise carotenoids differently than humans. Research was needed to determine how efficiently the β-carotene in Golden Rice is converted to circulating retinol, in children in developing countries where rice is the staple, the population segment which suffers most from VAD.
A February 2002 grant application to the US governments National Institutes of Health (NIH) for a project, which is entitled ‘Retinol Equivalents of Plant Carotenoids in Chinese Children’, states ‘This project is to determine the vitamin A value (equivalence) of dietary provitamin A carotenes from spinach, Golden Rice, and pure β-carotene (β-c) in oil. These experiments will be conducted in children (ages 6–8) with/without adequate vitamin A nutrition’.
On February 10, 2004, Tufts University Institutional Review Board (IRB) approved the research Protocol for ‘Retinol Equivalents of Plant carotenoids in Chinese Children’ and noted that ‘The Zhejiang Academy of Medical Sciences [China] approval is on file’.
On March 11, 2008, the Tufts IRB reviewed and on May 10, 2008, approved the study ‘Vitamin A Value of Plant Carotenoids (Spinach and Golden Rice in Children)’ based on the Protocol ‘Retinol equivalents of plant carotenoids in Chinese children’. Both Protocols referenced ‘NIH grant proposal 1R01 DK060021’.
On March 30, 2008, with respect to ‘Retinol Equivalents of Plant carotenoids in Chinese Children’ and ‘NIH Grant 1R01 DK060021-01’: The Ethical Review Committee of Zhejiang Academy of Medical Sciences confirmed that they had ‘reviewed the proposed use of human subject identified on June 27, 2003’ and certified that ‘the approval notice is still valid’.
Although the Chinese children research was planned in 2003, various practical setbacks in the production2 of the deuterium-labelled Golden Rice [9] meant that the field work in China was not completed until mid-June 2008 and, due to the complexity of analysis combined with limited analytical resources, publication not until 2012.
In the meantime, similar research was approved and conducted with adult volunteers in the USA. Data confirmed that 3.8 molecules of β-carotene derived by consumption of a single meal of Golden Rice converted to one molecule of circulating retinol [42]; this 3.8:1 bioconversion compared very favourably with conversion ratios established using other plant sources [33]. When the Chinese children research were published online on August 8, 2012, the authors reported a bioconversion ratio of 2.3:1.0, later adjusted to 2.1:1.0, and neither ratio significantly different, statistically, from the 2.0:1.0 of β-carotene in oil, another treatment in the same research. A third treatment, spinach, showed a 7.5:1.0 conversion. In each case the sophisticated research design measured the efficiency of conversion of β-carotene to circulating retinol following a single meal containing the β-carotene source. The publication noted that ‘In summary, the high bioconversion efficiency of Golden Rice β-carotene to vitamin A shows that this rice can be used as a source of vitamin A. Golden Rice may be as useful as a source of preformed vitamin A from vitamin A capsules, eggs or milk to overcome VAD in rice-consuming populations’ [4, 6].
These results were clearly very different from Greenpeace’s 2001 prediction. Instead of welcoming the excellent news of a potentially useful additional VAD intervention, Greenpeace, on August 29, 2012, issued a further press release in China from their Netherlands HQ: ‘Greenpeace alarmed at US-backed GE food trial on Chinese children’…‘It is incredibly disturbing to think that an American research body used Chinese children as guinea pigs for genetically engineered food,… The relevance of this study is questionable,…Nor does high conversion rate solve all the technical, environmental and ethical issues around Golden Rice’ [6, 10]. Greenpeace claimed that the Chinese authorities agreed to halt the research before it started3 but were unable to substantiate their claim to an independent journalist. The press release created hysteria in China and, 4 years after the field research had been completed, caused the parents of the subject children consternation.
Tufts University IRB carried out an investigation and concluded that there were ‘no concerns related to the integrity of the study data, the accuracy of the research results or the safety of the research subjects. In fact, the study indicated that a single serving of the test product, Golden Rice, could provide greater than 50 percent of the recommended daily intake of vitamin A in these children, which could significantly improve health outcomes if adopted as a dietary regimen’. Tufts also noted that ‘the research itself was found not to have been conducted in full compliance with IRB policy or federal regulations’ [43].
Eventually following this Greenpeace Press release, Tang et al. (2012) was retracted by the American Society of Clinical Nutrition in 2015 for procedural reasons. The full details of this and other impediments to Golden Rice’s development are given elsewhere [6, 9, 10, 43].
Separately, the Chair of the Tufts IRB, a computer scientist, in complaint to the publisher of one critical review of the case [10], wrote: ‘There was no research ethics committee or IRB review and approval in effect for the study when it was conducted in 2008’. This gross error of fact, with reference to the NIH grant and related IRB authorisations quoted above, itself calls into question the professionalism or objectivity of the 2012 Tufts IRB review which led to the retraction. (The research sophistication and quality of the retracted paper can be reviewed online [44]).
Henry Miller, a physician, molecular biologist and the founding director of the US Food and Drug Administration (FDA), commented in 2015 on the retracted paper: ‘A 2012 article in the nutrition literature might have been the most momentous contribution to public health worldwide since Dr. Jonas Salk’s announcement of the polio vaccine. The operative phrase is might have been, because intimidation, politics and the dishonest, anti-science efforts of NGOs to impugn the research have delayed the translation of its findings to life-saving interventions for millions of children. Why do anti-genetic engineering activists want to save the whales but let children go blind and die?’ [45].
The data generated by the above-mentioned research allow determination of the proportion of the estimated average requirement (EAR) the β-carotene content of Golden Rice can provide to children and adults (Table 2). If Golden Rice was the sole source of β-carotene in the diet, 50% of the EAR is sufficient to combat VAD [46]. Many nutritionists consider that supply of 30–40% of the EAR will be sufficient to combat VAD because the biofortified staple crop is seldom the only source of β-carotene. (The recommended daily allowance—RDA—which implies maintenance of 3-months liver stores of vitamin A, is not required to combat VAD.) The calculations (Table 2) use the β-carotene levels observed in different Golden Rice cultivars (e.g. RC82, BR29, IR36, IR64) of Golden Rice GR2E 2 months after harvest, when degradation has stabilised. A 6% loss of β-carotene in cooking Golden Rice, or 25% loss of β-carotene when a Golden Rice meal is parboiled first, and then reheated, has not been taken into account.
Amount of β-carotene in Golden Rice μg/g | Rice consumption per day (g of dry rice before cooking) | Percentage of EAR provided | |
---|---|---|---|
4.0 | 40 | 36% | |
4.0 | 100 | 91% | |
6.0 | 40 | 54% | |
6.0 | 100 | 136% | |
11.2 | 40 | 102% | |
11.2 | 100 | 254% | |
4.0 | 40 | 20% | |
4.0 | 100 | 50% | |
6.0 | 40 | 30% | |
6.0 | 100 | 75% | |
11.2 | 40 | 56% | |
11.2 | 100 | 140% |
The potential for Golden Rice to deliver the estimate average requirement of β-carotene, as a source of vitamin A, to 1–3-year-old children and adults.
For 1- to 3-year-old child, 100% of EAR is 210 μg RAE/day. An EAR that does not ensure adequate stores but is enough for normal dark adaptation is set at 112 μg ~50% EAR [46]
Golden Rice differs from white rice only in that it contains β-carotene, that is, provitamin A, which the human body converts to vitamin A. Golden Rice contains no vitamin A itself. So the question about safety relates principally to β-carotene, which is anyway ubiquitous in a balanced human diet and the environment.
At the levels found in food, β-carotene is a safe source of vitamin A, and classed as ‘generally recognised as safe’ (GRAS), by the United States Food and Drug Administration (US FDA) [47, 48]. At these physiological doses, consumption of β-carotene over several years has no adverse health effects [49, 50, 51, 52]. The human body only converts to vitamin A, in the form of circulating retinol, the amount of β-carotene necessary, with the rest being excreted or stored unchanged in body tissues (e.g. fat, liver, etc.). It is impossible to induce vitamin A toxicity by consuming β-carotene (pers. comm. Dr. R Russell).
In all β-carotene-containing crops, immediately after harvest the level of β-carotene reduces. For Golden Rice carotenoid degradation mechanisms have been thoroughly investigated4 and the products of degradation quantitated. Additionally, 102 plant food items from Philippine markets, together with orange- or yellow-coloured soft drinks, as well as non-gmo field grown, in all cases, orange maize cobs and yellow cassava storage roots from Zambia, and orange-fleshed sweet potato tubers from Uganda, were analysed for the cleavage products of β-carotene, apocarotenoids [53]. The potential risks arising from ‘aberrant plant carotenoid synthesis’ [54] in genetically modified plants, including Golden Rice, or from non-gmo crops biofortified with pro-vitamin A, have been thoroughly investigated, the authors reporting that ‘Our analysis and quantification of β-carotene derived cleavage products across biofortified and non-biofortified crop plant tissues combined with the calculation of potential exposure document no reason for concern’ [53].
For the formal regulatory approvals for the use of a gmo crop in food, as animal feed or in food or feed processing, on a country by country basis, detailed data sets have to be submitted. For permission to grow a gmo crop in a country, additional data have to be generated5 and submitted showing environmental safety.6 The ‘food, feed and processing’ data package developed for Golden Rice GR2E is extensive (42 megabytes of data). It is available without cost to all Golden Rice licensee countries consistent with long-standing Golden Rice Humanitarian Board policy. Here are the key summaries of the regulatory data submission made in the Philippines:
Although it is hard to imagine that such golden grains of polished Golden Rice could be included in commercial shipments of white rice by accident, in the modern world, any such inclusion could be damaging to international trade. To prevent even such an unlikely situation, the Golden Rice regulatory data have been submitted to regulatory authorities in countries which import rice, where VAD is not a public health issue. As a result of these data submissions, Golden Rice GR2E has been confirmed as safe for use as food, in feed, and for processing by the government’s regulatory authorities in Australia, Canada, New Zealand and USA. The regulatory deliberations and decisions are publicly available: Australia and New Zealand,8 Canada9 and the USA.10
Because in these industrialised countries rice forms only a tiny proportion of standard diets which already contain ample sources of vitamin A, the amounts of β-carotene in Golden Rice would have no significant additional nutritional benefit there. Comments to this effect by the US regulatory authorities were implied by anti-gmo crop opponents to be applicable also in developing countries where the dietary situation is completely different. Such implication has been rebutted by the US FDA [55]. The regulators in these industrialised countries concurred with Tufts University’s statement issued after their investigation of the ‘Chinese children’ research: ‘… Golden Rice, …could significantly improve health outcomes if adopted as a dietary regimen’ [43].
Further regulatory submissions have been made, and registrations are expected, in countries where VAD is a public health problem [56]. In the Philippines the process is not yet complete; nevertheless various government departments have already expressed their support.11
Gmo crops have been vilified by activist groups since the 1990s. ‘Frankenstein foods’ were used in a letter in the
Notwithstanding this opposition, all independent scientific institutions globally have determined, for many years, that there is no inherent danger to crop plants, or the human use of crops plants, or the environment from transferring genes from one organism to another, to create gmo crops, also known as genetically engineered (GE) crops, including transfer of genes between species which cannot sexually reproduce to transfer the genes ‘naturally’ [6, 58, 59].
Norero [60] provides a list of more than 240 independent science institutions from all over the globe which have commented on the safety of the techniques of genetic modification. A particularly clear reference comes from the heart of the geography politically most opposed to gmo technology, the European Commission of the European Union:
‘The main conclusion to be drawn from the efforts of more than 130 research projects, covering a period of more than 25 years of research and involving more than 500 independent research groups, is that biotechnology, and in particular GMOs, are not per se more risky than, for example, conventional plant breeding technologies’ [61].
At the time of writing, 141 Nobel Laureates, of about 290 living, have signed an open letter dated June 29, 2016, addressed to the leaders of Greenpeace, the United Nations and governments around the world calling for the campaign against Golden Rice specifically, and crops and foods improved through biotechnology in general, to cease ‘Opposition based on emotion and dogma contradicted by data must be stopped’ [8]. The letter also has the support of more than 13,000 other scientists and citizens.
Golden Rice seed and regulatory data packages are available—without cost—to public-sector rice-breeding institutions in less developed countries where rice is the staple and vitamin A deficiency endemic. Supply is subject only to national and international regulations and simple and free agreements [4]. The licences ensure that the inventor’s, Professors Potrykus and Beyer, objectives for their donated technology cannot be frustrated: only publicly owned rice varieties can be used, and the nutritional trait cannot be ‘stacked’ with any other gmo trait, unless the latter is also under the control of the public sector. There will be no charge to growers or consumers for the nutritional trait: Golden Rice will cost the same as white rice. Golden Rice homozygous seed, which breeds true generation to generation, will be provided by public-sector rice breeders. All small-holder family farmers—responsible for 80% of global rice production [38]—will eventually have access to it, with (except for commercial export—not a resource-poor farmer activity) no limitations on planting or replanting, harvest or sale of seed or grain.
Addressing micronutrient malnutrition, including VAD, is consistently ranked by the Copenhagen Consensus process, as the first, or at least within the top 5, most cost-effective investments with the potential to address the world’s 30 most intractable problems [62, 63, 64]. Investing in alleviating malnutrition would repay $45 for each dollar invested compared with $36 from fighting malaria and $10 from combatting HIV [65].
Compared with the World Bank standard, or the full cost of provision of vitamin A capsules, a common dietary supplement intervention for VAD since the early 1990s [15, 22], the cost of Golden Rice to save each disability-adjusted life year (DALY) is expected to be very low, perhaps US$0.5 [9, 66, 67].
Economists have calculated that conservative adoption of Golden Rice would benefit the gross domestic product (GDP) of Asian countries by US$6.4 billion (value in US$ of 2005) annually through increased productivity enabled by reduced vitamin A deficiency-induced sickness, and improved eyesight, and ~US$17.4 billion (value in US$ of 2005) if Golden Rice adoption encouraged adoption of other nutritional traits in rice [68]. Recently, HarvestPlus has exceeded target levels of iron and zinc in rice, which they were unable to achieve by conventional breeding, using gmo techniques [16]. Genetic modification has also been used to introduce folate into rice endosperm [27, 69]. The delay to the introduction of Golden Rice in India has been calculated to have cost Indian GDP US$199 million per annum for the decade from 2002 [70, 71], in total about US$1.7 billion (value in US$ of 2014).
Adoption of biofortified crops, including Golden Rice, will facilitate attainment of six of the most important Sustainable Development Goals 2015–2030 (Table 4). The standard costs used by the economists referenced in Tables 3 and 4 [62, 63, 64, 66, 67] refer to the costs of supplementation with vitamin A capsules. As when using Golden Rice, the vitamin A source has zero cost to the grower or consumer; the cost benefit of Golden Rice will be very significantly better than using vitamin A capsules.
Costs (US$ of 2006) | Highest efficiency | Lowest efficiency | ||
---|---|---|---|---|
World Bank cost-effective standarda | $200 | $200 | ||
Providing vitamin A capsulesa | $134 | $599 | ||
Vitamin A fortification of fooda | $84 | $98 | ||
Golden Rice, India @ 12:1a | $3.10 | $19.4 | ||
Golden Rice, Bangladesh 6:1b & 12:1c | $4.0b | $54.0c | ||
Golden Rice, abovea,b,c adjusted 2.1:1d | $0.5 | $1.4 | $3.4 | $9.5 |
Relative costs of saving one disability-adjusted life year using different sources of vitamin A and, for Golden Rice, different bioconversion ratios of β-carotene to circulating vitamin A.
The earlier studies occurred before these bioconversion ratios had been elucidated
Goal # | Goal | Potential impact of biofortification |
---|---|---|
1 | No poverty | Micronutrients in staple crops reduce effects |
2 | Zero hunger | Whole populations will be micronutrient sufficient |
3 | Good health | Provitamin A, Fe, Zn, Folate: less morbidity and mortality |
4 | Quality education | Pupils learn when adequately fed: Fe important |
5 | Gender equality | Biofortified staples available to whole population |
7 | Decent work and economic growth | Increased productivity from biofortified rice alone will add US$17.4 (in US$ of 2005) to Asian GDP |
Biofortification and some Sustainable Development Goals 2015–2030.
Vitamin A deficiency remains a huge public health problem despite existing interventions. Biofortification of staple foods is a new policy priority internationally. Golden Rice is safe. There is excellent human evidence that it will work. It is expected to be extremely cost-effective.
For successful adoption of Golden Rice as an additional intervention for vitamin A deficiency, the support of public health professionals is critical.
Dr. Robert Russell chaired the ‘panel on micronutrients’ the output of which, published in 2001 [72], created the US Governments’ dietary reference intakes for 14 micronutrients, including vitamin A. Also, in 2001, he joined the Golden Rice Humanitarian Board. I am grateful for his nutritional advice and instruction over the intervening years and for checking my calculations in connection with Table 2 and the surrounding text. I have known Dr. Guangwen Tang almost as long and thank her for providing, years ago, copies of the original documents which allowed me to construct with confidence the chronology of the IRB permissions 2003 and 2008 in the USA and China, all referring to the same NIH grant. Since 2015, the project has benefited from another specialist professional, Dr. Donald MacKenzie, who, aside from managing the GR2E regulatory data package generation, compilation and submissions, has also provided the web-links, which I have listed as footnotes in the ‘Safety’ section of this chapter. Thank you, Don, for your critically important work.
The author declares no conflict of interest.
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The data provided by the medical laboratories have a direct impact on patient safety and a fault in any of processes such as strategic, operational and support, could affect it. To provide appreciate and reliable data to the physicians, it is important to emphasize the need to design risk management plan in the laboratory. Failure Mode and Effect Analysis (FMEA) is an efficient technique for error detection and reduction. Technical Committee of the International Organization for Standardization (ISO) licensed a technical specification for medical laboratories suggesting FMEA as a method for prospective risk analysis of high-risk processes. FMEA model helps to identify quality failures, their effects and risks with their reduction/elimination, which depends on severity, probability and detection. Applying FMEA in clinical approaches can lead to a significant reduction of the risk priority number (RPN).",book:{id:"9808",slug:"contemporary-topics-in-patient-safety-volume-1",title:"Contemporary Topics in Patient Safety",fullTitle:"Contemporary Topics in Patient Safety - Volume 1"},signatures:"Hoda Sabati, Amin Mohsenzadeh and Nooshin Khelghati",authors:[{id:"340486",title:"M.Sc.",name:"Hoda",middleName:null,surname:"Sabati",slug:"hoda-sabati",fullName:"Hoda Sabati"},{id:"348872",title:"M.Sc.",name:"Amin",middleName:null,surname:"Mohsenzadeh",slug:"amin-mohsenzadeh",fullName:"Amin Mohsenzadeh"},{id:"348874",title:"MSc.",name:"Nooshin",middleName:null,surname:"Khelghati",slug:"nooshin-khelghati",fullName:"Nooshin Khelghati"}]},{id:"28882",title:"Infectious Disease and Personal Protection Techniques for Infection Control in Dentistry",slug:"infectious-disease-and-personal-protection-techniques-for-infection-control-in-dentistry",totalDownloads:4832,totalCrossrefCites:0,totalDimensionsCites:1,abstract:null,book:{id:"1820",slug:"infection-control-updates",title:"Infection Control",fullTitle:"Infection Control - Updates"},signatures:"Bahadır Kan and Mehmet Ali Altay",authors:[{id:"99656",title:"Dr.",name:"Bahadir",middleName:null,surname:"Kan",slug:"bahadir-kan",fullName:"Bahadir Kan"},{id:"131781",title:"Dr.",name:"Mehmet Ali",middleName:null,surname:"Altay",slug:"mehmet-ali-altay",fullName:"Mehmet Ali Altay"}]},{id:"76011",title:"The Role of the Radiation Safety Officer in Patient Safety",slug:"the-role-of-the-radiation-safety-officer-in-patient-safety",totalDownloads:451,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The role of the Radiation Safety Officer (RSO) is to prevent unnecessary exposure to ionizing radiation and maintain necessary exposures as low as reasonably achievable (ALARA). The RSO is delegated broad authority throughout the organization by senior management. This authority includes permission to stop unsafe practices and identifying radiation protection problems, initiating, recommending, or providing corrective actions and verifying implementation of these actions. For the most part, these efforts are focused on maintaining radiation doses to employees and the public ALARA. Regulations do not address a role for the RSO in reducing radiation exposure to patients, except when unnecessary exposure is suspected due to equipment malfunction or human error. There is increasing concern about the risks of cancer and other effects from the use of medical imaging procedures. This chapter will discuss the tools and resources available to the RSO to educate members of the medical community and senior management on the need to manage radiation doses to patients so that the physician is able to obtain information necessary to properly diagnose and treat patients while avoiding unnecessary exposure.",book:{id:"9808",slug:"contemporary-topics-in-patient-safety-volume-1",title:"Contemporary Topics in Patient Safety",fullTitle:"Contemporary Topics in Patient Safety - Volume 1"},signatures:"Thomas L. Morgan and Sandy Konerth",authors:[{id:"343320",title:"Dr.",name:"Thomas L.",middleName:"Logan",surname:"Morgan",slug:"thomas-l.-morgan",fullName:"Thomas L. 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Vice-versa, the HF with preserved ejection fraction (diastolic HF or HFpEF phenotype) is a much more complex syndrome, in which co-morbidities (such as COPD, depression, anemia, and diabetes, CAD) play a significant role in the decompensation episodes.",book:{id:"4650",slug:"primary-care-in-practice-integration-is-needed",title:"Primary Care in Practice",fullTitle:"Primary Care in Practice - Integration is Needed"},signatures:"Monica Lorenzini, Caterina Ricci, Silvia Riccomi, Federica Abate,\nBarbara Casalgrandi, Benedetta Quattrini, Gianbattista Spagnoli,\nLetizia Reggianini and Oreste Capelli",authors:[{id:"110047",title:"Dr.",name:"Oreste",middleName:null,surname:"Capelli",slug:"oreste-capelli",fullName:"Oreste Capelli"},{id:"111587",title:"Dr.",name:"Silvia",middleName:null,surname:"Riccomi",slug:"silvia-riccomi",fullName:"Silvia Riccomi"},{id:"174922",title:"Dr.",name:"Monica",middleName:null,surname:"Lorenzini",slug:"monica-lorenzini",fullName:"Monica Lorenzini"},{id:"176492",title:"Dr.",name:"Caterina",middleName:null,surname:"Ricci",slug:"caterina-ricci",fullName:"Caterina Ricci"},{id:"176493",title:"Dr.",name:"Letizia",middleName:null,surname:"Reggianini",slug:"letizia-reggianini",fullName:"Letizia Reggianini"},{id:"186451",title:"BSc.",name:"Federica",middleName:null,surname:"Abate",slug:"federica-abate",fullName:"Federica Abate"},{id:"186452",title:"BSc.",name:"Barbara",middleName:null,surname:"Casalgrandi",slug:"barbara-casalgrandi",fullName:"Barbara Casalgrandi"},{id:"190027",title:"Dr.",name:"Gianbattista",middleName:null,surname:"Spagnoli",slug:"gianbattista-spagnoli",fullName:"Gianbattista Spagnoli"},{id:"190029",title:"MSc.",name:"Benedetta",middleName:null,surname:"Quattrini",slug:"benedetta-quattrini",fullName:"Benedetta Quattrini"}]},{id:"60411",title:"Defining Adverse Events and Determinants of Medical Errors in Healthcare",slug:"defining-adverse-events-and-determinants-of-medical-errors-in-healthcare",totalDownloads:1552,totalCrossrefCites:3,totalDimensionsCites:4,abstract:"The concept of error typically regards an action, not its outcome, and its meaning becomes clear when separated into categories (medical error, nurse perceptions of (medication) error, diagnostic error). One wrong action may or may not lead to an adverse event either because the abovementioned action did not cause any serious damage to patients’ health condition or because it was promptly detected and corrected. The concept of error, on the contrary, which is used alternatively in the study, refers to the adverse outcome of an action. The responsibility for the emergence of errors in healthcare systems is shared among the nature of the healthcare system that is governed by organizational and functional complexity, the multifaceted and uncertain nature of medical science, and the imperfections of human nature. Medical errors should be examined as errors of the healthcare system, in order to identify their root causes and develop preventive measures. The main aims of this chapter are the following: (1) to understand medical errors and adverse events and define the terms that describe them; and (2) the most excellent way to comprehend how medical errors and adverse events occur and how to prevent them. Moreover it makes clear their classification and their determinants.",book:{id:"6672",slug:"vignettes-in-patient-safety-volume-3",title:"Vignettes in Patient Safety",fullTitle:"Vignettes in Patient Safety - Volume 3"},signatures:"Vasiliki Kapaki and Kyriakos Souliotis",authors:[{id:"201567",title:"Associate Prof.",name:"Kyriakos",middleName:null,surname:"Souliotis",slug:"kyriakos-souliotis",fullName:"Kyriakos Souliotis"},{id:"201568",title:"Dr.",name:"Vasiliki",middleName:null,surname:"Kapaki",slug:"vasiliki-kapaki",fullName:"Vasiliki Kapaki"}]}],onlineFirstChaptersFilter:{topicId:"1135",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],testimonialsList:[]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"May 18th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{},overviewPageOFChapters:[],overviewPagePublishedBooks:[],openForSubmissionBooks:{},onlineFirstChapters:{},subseriesFiltersForOFChapters:[],publishedBooks:{},subseriesFiltersForPublishedBooks:[],publicationYearFilters:[],authors:{paginationCount:148,paginationItems:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/165328/images/system/165328.jpg",biography:"Vahid Asadpour, MS, Ph.D., is currently with the Department of Research and Evaluation, Kaiser Permanente Southern California. He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:null},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"357085",title:"Mr.",name:"P. Mohan",middleName:null,surname:"Anand",slug:"p.-mohan-anand",fullName:"P. Mohan Anand",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356696",title:"Ph.D. Student",name:"P.V.",middleName:null,surname:"Sai Charan",slug:"p.v.-sai-charan",fullName:"P.V. Sai Charan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"357086",title:"Prof.",name:"Sandeep K.",middleName:null,surname:"Shukla",slug:"sandeep-k.-shukla",fullName:"Sandeep K. Shukla",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356823",title:"MSc.",name:"Seonghee",middleName:null,surname:"Min",slug:"seonghee-min",fullName:"Seonghee Min",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Daegu University",country:{name:"Korea, South"}}},{id:"353307",title:"Prof.",name:"Yoosoo",middleName:null,surname:"Oh",slug:"yoosoo-oh",fullName:"Yoosoo Oh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:"Yoosoo Oh received his Bachelor's degree in the Department of Electronics and Engineering from Kyungpook National University in 2002. He obtained his Master’s degree in the Department of Information and Communications from Gwangju Institute of Science and Technology (GIST) in 2003. In 2010, he received his Ph.D. degree in the School of Information and Mechatronics from GIST. In the meantime, he was an executed team leader at Culture Technology Institute, GIST, 2010-2012. In 2011, he worked at Lancaster University, the UK as a visiting scholar. In September 2012, he joined Daegu University, where he is currently an associate professor in the School of ICT Conver, Daegu University. Also, he served as the Board of Directors of KSIIS since 2019, and HCI Korea since 2016. From 2017~2019, he worked as a center director of the Mixed Reality Convergence Research Center at Daegu University. From 2015-2017, He worked as a director in the Enterprise Supporting Office of LINC Project Group, Daegu University. His research interests include Activity Fusion & Reasoning, Machine Learning, Context-aware Middleware, Human-Computer Interaction, etc.",institutionString:null,institution:{name:"Daegu Gyeongbuk Institute of Science and Technology",country:{name:"Korea, South"}}},{id:"262719",title:"Dr.",name:"Esma",middleName:null,surname:"Ergüner Özkoç",slug:"esma-erguner-ozkoc",fullName:"Esma Ergüner Özkoç",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Başkent University",country:{name:"Turkey"}}},{id:"346530",title:"Dr.",name:"Ibrahim",middleName:null,surname:"Kaya",slug:"ibrahim-kaya",fullName:"Ibrahim Kaya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"419199",title:"Dr.",name:"Qun",middleName:null,surname:"Yang",slug:"qun-yang",fullName:"Qun Yang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Auckland",country:{name:"New Zealand"}}},{id:"351158",title:"Prof.",name:"David W.",middleName:null,surname:"Anderson",slug:"david-w.-anderson",fullName:"David W. Anderson",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Calgary",country:{name:"Canada"}}}]}},subseries:{item:{id:"6",type:"subseries",title:"Viral Infectious Diseases",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11402,editor:{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. 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