How the ABO blood group system affect susceptibility and resistance to
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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"3361",leadTitle:null,fullTitle:"Regenerative Medicine and Tissue Engineering",title:"Regenerative Medicine and Tissue Engineering",subtitle:null,reviewType:"peer-reviewed",abstract:"Few events in science have captured the same level of sustained interest and imagination of the nonscientific community as Stem Cells, Tissue Engineering, and Regenerative Medicine. The fundamental concept of Tissue Engineering and Regenerative Medicine is appealing to scientists, physicians, and lay people alike: to heal tissue or organ defects that the current medical practice deems difficult or impossible to cure. Tissue engineering combines cells, engineering, and materials methods with suitable biochemical and physiochemical factors to improve or replace biologic functions. Regenerative medicine is a new branch of medicine that attempts to change the course of chronic disease, in many instances regenerating failing organ systems lost due to age, disease, damage, or congenital defects. The area is rapidly becoming one of the most promising treatment options for patients suffering from tissue failure. This book of Regenerative Medicine and Tissue Engineering fairly reflects the state of the art of these two disciplines at this time as well as their therapeutic application. It covers numerous topics, such as stem cells, cell culture, polymer synthesis, novel biomaterials, drug delivery, therapeutics, and the creation of tissues and organs. The goal is to have this book serve as a reference for graduate students, post-docs, teachers, scientists and physicians, and as an explanatory analysis for executives in biotech and pharmaceutical companies.",isbn:null,printIsbn:"978-953-51-1108-5",pdfIsbn:"978-953-51-4248-5",doi:"10.5772/46192",price:169,priceEur:185,priceUsd:219,slug:"regenerative-medicine-and-tissue-engineering",numberOfPages:868,isOpenForSubmission:!1,isInWos:1,isInBkci:!0,hash:"fe914d49a96b3dcd00d27292ae23536e",bookSignature:"Jose A. Andrades",publishedDate:"May 22nd 2013",coverURL:"https://cdn.intechopen.com/books/images_new/3361.jpg",numberOfDownloads:101568,numberOfWosCitations:210,numberOfCrossrefCitations:87,numberOfCrossrefCitationsByBook:10,numberOfDimensionsCitations:230,numberOfDimensionsCitationsByBook:10,hasAltmetrics:0,numberOfTotalCitations:527,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 25th 2012",dateEndSecondStepPublish:"May 16th 2012",dateEndThirdStepPublish:"November 1st 2012",dateEndFourthStepPublish:"November 18th 2012",dateEndFifthStepPublish:"December 18th 2012",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,8,9",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"40914",title:"Prof.",name:"Jose A.",middleName:null,surname:"Andrades",slug:"jose-a.-andrades",fullName:"Jose A. Andrades",profilePictureURL:"https://mts.intechopen.com/storage/users/40914/images/3882_n.jpg",biography:"José A. Andrades completed his doctorate in Cellular Biology by the University of Málaga (Spain). He has been a Post-Doctoral fellow and Visiting Professor at Children’s Hospital Los Angeles, University of Southern California (Los Angeles, CA), as well as at the Skeletal Research Center, Case Western Reserve University (Cleveland, OH). He currently has a faculty position at the Department of Cell Biology, Genetics and Physiology (Laboratory of Bioengineering and Tissue Regeneration) at the University of Málaga. Dr. Andrades leads grants, and is author of scientific publications, focused on the study of the chondro-osteo-tendinogenesis by using mesenchymal stem cells, growth factors with specific molecular domains, and different biomaterials, for skeletal tissue engineering. The group has developed patents on cellular procedures that allow regeneration in bone/articular cartilage lesions of live animals. Currently, Dr. Andrades is coordinator of the Cellular Therapy Program NACRE (New Approaches for Cartilage Regeneration) in the CIBER-BBN. He belongs to the TerCel Network, and to the NanomedSpain, in which consortia develops collaborations with several groups of physicians for the clinical translation of their studies.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Malaga",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"980",title:"Tissue Engineering and Regenerative Medicine",slug:"tissue-engineering-and-regenerative-medicine"}],chapters:[{id:"44123",title:"Placenta-Derived Stem Cells as a Source for Treatment of Lung and Liver Disease in Cystic 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The reliability and safety of engineering objects are mostly formed during the design. Every design process has three stages:
Proposal of conception,
Determination of parameters,
Setting the tolerances.
Here, stages 2 and 3 will be explained in more detail, as they are very important for reliability.
After the concept of the construction (an engine, a bridge, a transmitter, etc.) has been proposed, it is necessary to determine all important parameters. However, input quantities often vary or can attain values different from those assumed in design. Good design ensures that the important output quantities will always lie within the allowable limits. This can be achieved by a suitable choice of nominal values of input quantities and by setting their tolerances.
The nominal values of input quantities form together the
Principle of robust design. Note the influence of the position of the design point on the sensitivity of the output (
After the design point has been found, the sensitivity analysis could be made to show the influence of the variations of input variables on the variability of the output [8]. The results may be used for setting the tolerances of input quantities to keep the output in the allowable range. The sensitivity analysis can be done using analytical expressions or simulation methods. The analytical expression for the output variable
is known exactly only in simple cases (e.g. resonant frequency of an oscillator or deflection of a beam). Often, the
The sensitivity analysis is usually done in two steps. First, the influence of individual variables is investigated. Several groups of computations are carried out, and in each group, only one variable (
or
the latter expression characterizes the changes of
In this case, linear approximation of the response function may be used, which yields simple expressions. The
For linear approximation, the sensitivity coefficients
where
Generally, two kinds of sensitivity analysis can be made: (1) deterministic, which assumes that the deviations of individual quantities from nominal values have constant magnitude, and (2) stochastic, which assumes the random scatter of individual input quantities around their nominal values.
Both approaches will be illustrated on an example [9]. A cantilever flat spring of rectangular cross-section (Fig. 2) should be used in a precise measuring device. It is necessary to get an idea how the deviations of its individual dimensions and material properties from the nominal values will influence its compliance. The spring compliance
Spring for a measuring device (a schematic).
The increments of
where ∂
In our example with the spring, the partial derivative of Equation (6) with respect to the first variable (
and the increment of compliance due to a small increment of the beam length ∆
The formulas for other variables are obtained in a similar way. The resultant expression, involving the changes of all variables, is
and the relative sensitivity of the stiffness is
This formula shows the influence of individual quantities. If the spring will be longer by 1% than the nominal value, the compliance will be higher by 3%; if the elastic modulus
This preliminary analysis reveals which input quantities have very small influence on the variability of the output quantity
The above approach is acceptable if the response function is linear or if the errors due to approximation by linear function are small. If the response function is nonlinear and the investigated ranges of input quantities are not small, the errors will not be negligible (Fig. 3). In such case, it is better to study the influence of deviations of input quantities by modeling the response without simplifications. For example, the influence of
Error caused by linear approximation of response function
The influence of random variability of input quantities can be investigated using the formula for the scatter of a function of several random variables. For small scatter,
where
the scatter is
The individual components,
The expression obtained by dividing Equation (10) or (12) by the total scatter
The square root of scatter (10) is the standard deviation
the + or – sign corresponds to the upper (or lower) confidence limit and
If Formula (12) is applied on the above example with a spring, one obtains the following expression for the standard deviation of the compliance caused, for example, by random variability of the length
cf. Equation (11). Similar expressions can be written for other variables. The random variability of all input quantities causes the following variability of the spring compliance:
The ratio of the standard deviation of a quantity and its mean is the variation coefficient,
so that the combination of Equations (16) and (17) gives the variation coefficient of the compliance,
The above approach, based on the linearization of the response function, is suitable for small values of variance coefficients of input quantities, say
The approximate value of the total scatter is obtained by summing up the partial scatters,
More accurate value is obtained if all input variables,
If the variability or deviation of the output quantity
If the deviation of
For example, the allowable length tolerance of the above spring, ensuring the compliance tolerance ∆
The tolerances of other quantities can be determined in similar way. One must respect that the deviations of some input quantities influence the output in one direction, whereas the deviations of other quantities can have the opposite influence. Generally, the deviations of
The following analysis assumes that the range of probable occurrence of
Often, the influence of one factor prevails (e.g.
If several input variables vary, one must decide, which of them should be reduced. As the standard deviation equals the square root of the scatter, it is obvious that the reduction of scatter of a quantity, contributing to the total scatter by only 5% to 10%, will have negligible effect. Also, the costs of the pertinent improving operation must be considered, as they usually increase with tightening the tolerances.
After having obtained the corrected standard deviation
The above optimization can be performed even if the scatter
Often, the scatter of some input quantities cannot be changed continuously. In such cases, the response must be evaluated for each possible value of every discontinuous quantity.
The determination of suitable tolerances will be illustrated on the following example, adapted from [9].
A cantilever microbeam from Figure 2, with length
Solution. The corresponding reduced variation coefficient is
With the variation coefficient of elastic modulus unchanged,
If the high reliability of a certain object must be ensured, a proof-test is often used: the component is exposed to some overload, specified so that only sufficiently strong components survive it; the weaker ones are destroyed. In the same way, sufficient lifetime can be ensured for components made of brittle materials suffering by static fatigue. The minimum time to failure of a component that has passed a proof-test is [10 - 12]
where
However, KIC, N, and A were determined by measurement and are known only approximately and Y was estimated. Therefore, it is recommended to perform sensitivity analysis and correct the proof stress appropriately. The pertinent theory, based on probabilistic analysis, is explained in [11, 12] or in [10]. For easier application, strength-probability-time diagrams were developed [13 – 15], in which the necessary proof stress can be found for the demanded time to failure and confidence level.
Malaria is one of the prevalent infectious diseases globally. In malaria-endemic areas, a significant proportion of children harbor parasites without presenting signs of clinical malaria and are considered asymptomatic cases [1]. Moreover, in communities where children are repeatedly infected with malaria, one can question why some children die while others do not. Variant-specific immunity may help explain chronic low-grade malaria infection without clinical symptoms [2]. A better knowledge of the polymorphic host genes associated with resistance to clinical malaria and/or with high parasite densities might provide new insights into disease mechanisms, and suggest new approaches for prophylactic or therapeutic interventions [3, 4].
The ABO blood groups consist of A, B, and H carbohydrate antigens which can regulate protein activities during infection and antibodies against these antigens [9, 10, 11]. Several studies did try to establish an association between severe malaria and the ABO-blood group type [11, 12, 13], with some reporting significant associations on infection status and a particular ABO blood group [11, 13].
The relationship between ABO and malaria was first suggested more than 40 years ago [14]. Few studies have corroborated this hypothesis [8, 11, 14, 15], but some studies showed a weak association [2]. In India, for example, a significantly lower frequency of
This study aimed to investigate the association between the ABO blood group and malaria susceptibility among Fulani compared to other sympatric ethnic groups living in Burkina Faso.
We offer four perspectives in support of this investigation:
The prevalence of the ABO blood group, in both children and adults residing in the rural areas of Burkina Faso;
The current distribution of ABO groups and
Clinical outcomes during
For a long time ago, the ABO blood group system has been suggested to be associated with infectious diseases including malaria. ABO blood groups appear to protect against malaria, through loss of function due to a defective allele: the O phenotype of the ABO system seems to confer protection against
Gene (chromosome) | Protein | Mutation | Number of mutations | Variant | Reported Genetic Associations with Malaria | Mechanistic hypotheses proposed protective mechanism | Reference | Distribution | High-low Frequency |
---|---|---|---|---|---|---|---|---|---|
ABO (9q34) O | Glycosyl transferase enzyme | Deletion of nucleotide 261 in exon 6 | major | ABO single nucleotide deletion (rs8176719)-Blood group O | O alleles protect against uncomplicated malaria and severe malaria. | Reduced | Rowe et al. (2007), Rowe et al. (1995), Udomsangpetch et al. (1993), MalariaGEN (2014), Ndila et al. (2018), Tishkoff SA, et al. (2004). Silvia N. Kariuki | South America, Africa, Western Europe | Near 100% in native South Americans to about 0.3% in some Asians |
How the ABO blood group system affect susceptibility and resistance to
The human ABO gene consists of seven exons that are more than 18 kb in length and genomic analysis has found over 70 alleles at this locus, suggesting that it is one of the polymorphic genes in humans [1]. The three main antigenic classes (A, B, and O) are all comprised of numerous alleles in both coding and non-coding sequences [1].
The O alleles share a one-nucleotide deletion in codon 87 of exon 6 resulting in a frameshift mutation and premature termination of the polypeptide [2, 3]. O alleles are the most common of the three allelic classes (about 0.6 worldwide) and have frequencies between 0.3 and 0.7 in most populations. The A alleles generally have frequencies between 0.2 and 0.3, and the B alleles have frequencies between 0.1 and 0.2 [4]. There is substantial evidence supporting the importance of allele O for protecting against malaria, based primarily on the consistency between the worldwide distributions of ABO variants and the historical presence of malaria. Uneke (2007) showed that the O allele, which is more frequent in malaria-endemic regions, is associated with greater resistance to malaria, in contrast to the A and B genotypes, which are less resistant [5]. Fry et al. [6] corroborated this finding through a study in three African populations showing a strong association of O individuals with resistance to severe malaria and a recessive effect in AO and BO individuals. Consequently, AO and BO would have the same susceptibility or sensitivity to malaria as AA and BB individuals; with AB genotype individuals being the most sensitive. The O allele is thought to protect against severe malaria through a mechanism of reduced reinitiation (
However, although the major O alleles share a one-nucleotide deletion, they differ in the number of nucleotide substitutions in both exons and introns. The O human alleles, although different from the O chimpanzee allele [8], are much older [1]. The most common O alleles, O01 and O02, are the result of separate mutations and are 1.15 and 2.5 million years old, respectively. In other words, assuming that the O allele protects from malaria, this protection may be a result of selection originally favoring O alleles for some other reason.
The study was conducted in four shrub-savanna villages located northeast (Barkoumbilen and Barkoundouba) and east (Bassy and Zanga) of Ouagadougou, the capital city of Burkina Faso (see Figure 1).
Study site in Burkina. The study was carried out in four rural villages of shrubby savannah areas of Burkina Faso: northeast (Nioniokodogo and Barkoundouba), and east (Bassy and Zanga) of the capital town Ouagadougou. Compounds of the various ethnic groups are represented as capital letters. Inset/smaller map represents the study site relative to the whole country.
In the northeast zone, the Mossi and Rimaibè communities inhabit the village of Barkoumbilen, while the Fulani and Rimaibè inhabit the village of Barkoundouba. The Fulani and Rimaibe are present in both villages, so the Rimaibe represent an optimal internal control for the study. The two villages are 5 km apart. In the eastern zone, Mossi and Fulani communities independently inhabit two villages, Zanga and Bassy, about 1(one) km apart.
Malaria transmission in the study areas is hyperendemic and seasonal, with a rainy season from June to October. The entomological inoculation rate (EIR) is estimated to be around 200–300 infecting bites per person per year and is comparable between villages [6]. The main malaria vectors are
The population of the study area is predominantly of the Mossi ethnic group, followed by the widespread Fulani, who are generally closely associated with the Rimaibe (a hybrid of the two in terms of customs and even genetics). All three populations live in similar houses. However, the Fulani group, while adopting the habits of the sedentary Mossi populations, has retained their pastoral activities so that their habitat is characterized by the presence of cattle herds.
The total population of the four villages was obtained from a general census and enrolled in a demographic monitoring process. Except for children under 6 months of age, the entire population was eligible for the study and was characterized/designated into two groups: participants aged 0.6 to 17 years and participants aged 18 years and older.
The study was conducted for two consecutive years and consisted of five cross-sectional surveys (see Table 2).
Total subject (n) | Grouped by ethnicity | ||||
---|---|---|---|---|---|
Mossi n (%) | Fulani n (%) | Rimaibe n (%) | |||
559 | 163 | 209 | 176 | ||
380 (68.1) | 120 (73.2) | 147 (69.0) | 113 (62.4) | ||
178 (31.9) | 44 (26.8) | 66 (31.0) | 68 (37.6) | ||
224 (40.9) | 72 (44.2) | 90 (43.1) | 62 (35.2) | ||
324 (59.1) | 91 (55.8) | 119 (56.9) | 114 (64.8) | ||
40.5 (222) | 29.4 (48) | 52.6 (110) | 36.4 (64) | ||
26.6 (146) | 40.5 (66) | 13.4 (28) | 29.5 (52) | ||
25.5 (140) | 25.2 (41) | 28.7 (60) | 22.2 (39) | ||
7.3 (40) | 4.9 (8) | 5.3 (11) | 52.5 (21) | ||
59.2 (326) | 70.6 (115) | 47.4 (99) | 63.6 (112) |
Population demographic.
Four surveys during the high malaria transmission seasons: in the middle of August 2007 and 2008; and in the middle of November/December 2007 and 2008.
One survey in the middle of the low transmission/dry season: March 2008.
Community sensitization meetings were held during which information or explanations about the context of the study, its objectives, its methodological approach, and the associated ethical issues were provided. The signing of written informed consent was a requirement for all study participants, including the guardians of minor children.
Following consent, a clinical team of physicians and nurses examined all participants for clinical signs of malaria, measured weight, and axillary body temperature. Suspected malaria cases (T ≥ 37.5°C) were treated with artemether and lumefantrine.
During the first cross-sectional survey, a two (2) ml venous blood sample was collected from all participants in EDTA tubes.
Thick and thin blood smears were prepared and the hemoglobin level was measured by the HemoCue technique.
For each subject in this study, physical examination and capillary blood samples on slides and filter papers were collected. Slides were used for the diagnosis of malaria infection and the venous sampling was for the blood group characterization.
Blood slides were stained with Giemsa for microscope identification of the
Blood films were air-dried, the thin films fixed with methanol, and the slide stained with Giemsa. The slides were read by highly experienced laboratory technicians according to the site SOPs. Briefly, 100 high power fields were examined, and the number of malaria parasites/each species and stage was recorded. The number of parasites per microliter of blood was calculated assuming 200 white blood cells per high power field and a fixed white blood cell count of 8000/μL. A slide was considered negative if no parasites were found after the 100 HPF examination. Two independent microscopists read each slide and in case of discrepancy between the two readers, in terms of species, presence or absence of malaria parasites, or if the parasite densities differed by more than 30%, the slide was re-examined by a third laboratory technician. The arithmetic mean of the two closest readings was used as the final value of the parasite density. If there was no agreement after the third reading, the arithmetic mean of the three parasite densities was used.
DNA extraction from the buffy coat (about 1.5 ml in volume) was performed using Nucleon BACC2 Kits. Successful DNA extraction was checked on a 1% agarose gel stained with ethidium bromide. A total of 2235 DNA samples (about 50 μl in volume) were collected: 825 from Mossi, 877 from Fulani, and 533 from Rimaibè individuals. Samples were stored in screw cap tubes labeled with the study code. Samples were kept at −20°C in cryo boxes. The DNA samples were shipped to the WTCHG in Oxford, UK, in May 2008. The DNA samples of study participants were genotyped at the WTCHG in Oxford, UK.
Demographic variables collected during the census of the four villages include for each person; age, gender, father and mother ethnicity, village, compound, family members and sequential number within the family, and census code. Assignment of ethnicity has been performed with the assistance of local guides.
The census data file was anonymized (name identification has been removed for privacy protection) according to the study protocol which was approved by the ethical committee of Burkina Faso. Clinical data were matched to the census data with study enrolment codes. Case report forms (CRF) for cross-sectional surveys were verified by the supervisor of the clinical study before data entry. Similarly, parasitological data were verified by the lab supervisor before data entry. Data entry was conducted by a team of computer engineers at Ouagadougou, Burkina Faso, and data files were validated by the database manager.
Data were entered into Microsoft Access. A Chi-square test was used to assess the difference between frequencies/associations between blood groups and
Two-sided
The National Ethics Committee of the Ministry of Health (in Burkina Faso) granted ethical clearance. The study was conducted in compliance with the International Conference on Harmonization, Good Clinical Practices, the Declaration of Helsinki, and applicable Burkina Faso regulatory requirements. Individual written informed consent was obtained from each participant, participant’s parents, or legally acceptable representative.
This study aimed to investigate
A total of 548 subjects (380 children and 178 adults) were included in this study: Mossi, n = 163 (29.7%), Fulani, n = 209 (38.2%), and Rimaibe, n = 176 (32.1%). Table 2 shows baseline demographic characteristics according to ethnicity. We did not find any significant difference among the three ethnic groups. The ABO blood group analysis in all children revealed that O antigen: 40.5% (222/548) was the most predominant, followed by A: 25.5% (140/548), B: 26.6% (146/548), and AB: 7.3% (40/548) antigens. Blood group O was not only the commonest blood type overall, but was higher in the Fulani (n = 110 (52.6%)) than Mossi (n = 48 (29.4%)) and Rimaibe (n = 64 (36.4%)).
The malariometric indices for each cross-sectional survey are summarized in Table 3. The prevalence of
Malaria indices | *survey number | Total | Ethnic Group | P-value | ||||
---|---|---|---|---|---|---|---|---|
Mossi | Fulani | Rimaibe | F vs. M vs. R | F VS M | F vs. R | |||
Prevalence of Pf malaria Infection % (number positive/ total) | 1 | 283 (51.6) | 98 (60.1) | 91 (43.5) | 59 (52.7) | 0.08 | 0.025 | 0.30 |
2 | 236 (43.1) | 90 (55.2) | 54 (25.8) | 54 (48.2) | 0.002 | 0.003 | 0.00 | |
3 | 101 (18.4) | 33 (20.24) | 25 (12.0) | 26 (23.2) | 0.55 | 0.56 | 0.50 | |
4 | 272 (49.6) | 103 (63.2) | 69 (33.0) | 65 (58.0) | 0.0001 | 0.016 | 0.0001 | |
5 | 215 (39.2) | 87 (53.4) | 52 (24.9) | 47 (42.0) | 0.0056 | 0.0012 | 0.25 | |
Geometric mean of parasite density (p/μl) | 1 | 550 [441–687] | 865 [598–1252] | 374 [251–557] | 483 [331–708] | 0.021 | 0.001 | 0.316 |
2 | 313 [250–390] | 330 [228–478] | 297 [192–460] | 305 [211–441] | 0.932 | 0.634 | 0.050 | |
3 | 393 [289–536] | 230 [138–382] | 391 [195–780] | 572 [360–909] | 0.044 | 0.912 | 0.332 | |
4 | 264 [697–1040] | 685 [491–957] | 878 [578–1332] | 1030 [571–1414] | 0.253 | 0.036 | 0.51 | |
5 | 720 [563–920] | 791 [535–1167] | 523 [327–836] | 805 [520–1249] | 0.345 | 0.171 | 0.193 | |
Prevalence of clinical Pf cases % (number positive/total) | 1 | 52 (9.5) | 16 (9.8) | 18 (8.6) | 18 (10.2) | 0.98 | 0.88 | 0.78 |
2 | 13 (2.4) | 8 (4.9) | 4 (1.9) | 1 (0.1) | — | — | — | |
3 | 4 (0.7) | 0 (0.0) | 1 (0.5) | 3 (1.7) | — | — | — | |
4 | 31 (5.7) | 11 (6.7) | 9 (4.3) | 11 (6.3) | — | — | — | |
5 | 24 (4.4) | 13 (8.0) | 5 (2.4) | 6 (3.4) | — | — | — |
Malariometric indices according to the ethnicity group/survey.
Survey number.
1: First survey, the middle of high malaria transmission season (August 2008).
2: Second survey, the end of high malaria transmission season (Nov 2008).
3: Third survey, the middle of the dry low transmission season (March 2008).
4: The fourth survey, the start of the high transmission season (July 2008).
5: Fifth survey, the end of the high transmission season (November/December 2008).
The study showed that during the period of high transmission, there was an association between ethnicity and malaria infection (
Malaria indices | Survey number | Total | Ethnic group | P-value | |||||
---|---|---|---|---|---|---|---|---|---|
Mossi | Fulani | Rimaibe | F vs. M vs. R | F VS M | F vs. R | ||||
Prevalence of Pf malaria Infection % (number) | O | 98 (60.1) | 27 (56.3) | 46 (50.9) | 29 (45.3) | 0.724 | 0.64 | 0.60 | |
Non-O | 65 (39.9) | 71 (61.7) | 45 (45.5) | 59 (52.7) | 0.172 | 0.05 | 0.41 | ||
Non-O | A | 4.7 (5) | 27 (38.0) | 31 (33.7) | 22 (23.4) | 0.55 | 0.70 | 0.44 | |
B | 4.7 (5) | 41 (57.7) | 6 (6.6) | 24 (22.5) | 0.001 | 0.02 | 0.003 | ||
AB | 9.3 (10) | 3 (38.0) | 8 (8.8) | 13 (13.8) | — | — | — | ||
Geometric mean of parasite density (p/μl) [positive/ total] | O | 521 [359–755] | 1020 [486–2146] | 434 [237–767] | 373 [202–689] | 0.07 | 0.07 | 0.71 | |
Non-O | 569 [431–753] | 811 [525–1253] | 323 [188–555] | 563 [343–923] | 0.01 | 0.025 | 0.19 | ||
Non-O | A | 568 [382–845] | 1005 [489–2068] | 316 [167–599] | 595 [295–1205] | 0.04 | 0.012 | 0.173 | |
B | 535 [337–851] | 691 [393–1218] | 136 [23–822] | 494 [194–1260] | 0.16 | 0.04 | 0.19 | ||
AB | 680 [226–1561] | 928 [−] | 664 [128–3437] | 642 [204–2018] | 0.90 | 0.50 | 0.92 | ||
Prevalence of clinical Pf cases % (number positive/total) | O | 20 (9.0) | 4 (8.3) | 9 (8.2) | 7 (10.9) | — | |||
Non-O | 32 (9.8) | 12 (10.4) | 9 (9.1) | 11 (9.8) | — | ||||
Non-O | A | 7 (5.0) | 3 (7.3) | 3 (5.0) | 1 (2.6) | — | |||
B | 19 (13.0) | 8 (50.0) | 5 (27.8) | 4 (22.2) | — | ||||
AB | 6 (15.0) | 1 (12.5) | 1 (9.1) | 46 (19.6) | — | ||||
Prevalence of Pf malaria Infection % (number) | O | 39 (17.6) | 10 (20.8) | 12 (10.9) | 17 (26.6) | 0.38 | 0.86 | 0.36 | |
Non-O | 62 (19.0) | 23 (20.0) | 13 (13.1) | 26 (23.2) | 0.85 | 0.98 | 0.88 | ||
Non-O | A | 27 (19.3) | 11 (26.8) | 8 (13.3) | 8 (20.5) | 0.72 | 0.83 | 1.00 | |
B | 26 (17.8) | 11 (16.7) | 3 (10.7) | 12 (23.1) | — | — | — | ||
AB | 9 (25.5) | 1 (12.5) | 2 (18.2) | 6 (28.6) | — | — | — | ||
Geometric mean of parasite density (p/μl) [positive/ total] | O | 345 [207–575] | 185 [75–454] | 434 [237–767] | 483 [203–1143] | 0.18 | 0.34 | 0.57 | |
Non-O | 393 [288–536] | 253 [130–492] | 443 [149–1317] | 641 [360–1124] | 0.12 | 0.19 | 0.88 | ||
Non-O | A | 275 [152–495] | 172 [62–476] | 477 [96.1–2375] | 284 [144–558] | 0.33 | 0.20 | 0.42 | |
B | 533 [267–1064] | 337 [112–1014] | 185 [2.20–15,628] | 979 [348–2752] | — | — | — | ||
AB | 936 [447–1962] | 876 [−] | 1215 [0.0–1.7e09] | 855 [302–2419] | 0.075 | 0.46 | 0.052 | ||
Prevalence of clinical Pf cases % (number positive / total) | O | 1 (0.5) | 0 (0) | 0 (0) | 1 (1.6) | — | — | — | |
Non-O | 3 (0.9) | 0 (0.0) | 1 (0.0) | 1 (1.8) | — | — | — | ||
Non-O | A | 1 (0.7) | 0 (0.0) | 0 (0.0) | 1 (2.6) | — | — | — | |
B | 1 (0.0) | 0 (0.0) | 0 (0.0) | 1 (0.0) | — | — | — | ||
AB | 2 (5.0) | 0 (0) | 1 (9.1) | 1 (4.8) | — | — | — |
Malariometric indices according to the ethnicity and blood group/season.
F= Fulani; M= Mossi; R= Rimaibe; No-O = A + B + AB.
The subjects with Non-O blood (i.e. A, B, or AB) were less susceptible to malaria infection (
Blood group compared | All | Mossi | Fulani | Rimaibe |
---|---|---|---|---|
O vs. A | 0.028 | 0.17 | 0.12 | 0.49 |
O vs. B | 0.04 | 0.80 | 0.04 | 0.06 |
O vs. AB | 0.0067 | 0.90 | 0.11 | 0.13 |
O vs. (A + B + AB) | 0.011 | 0.56 | 0.59 | 0.49 |
O vs. A | 0.74 | 0.98 | 0.47 | 0.30 |
O vs. B | 0.91 | 0.34 | 0.18 | 0.57 |
O vs. AB | 0.53 | 0.71 | 0.52 | 0.33 |
O vs. (A + B + AB) | 0.000 | 0.58 | 0.52 | 0.29 |
O vs. A | 0.79 | 0.90 | — | 0.80 |
O vs. B | 0.84 | 0.65 | — | 0.87 |
O vs. AB | 0.85 | — | — | 0.73 |
O vs. (A + B + AB) | 0.86 | 0.72 | 0.94 | 0.91 |
O vs. A | 0.55 | 0.88 | 0.59 | 0.41 |
O vs. B | 0.28 | 0.34 | 0.53 | 0.27 |
O vs. AB | 0.08 | — | 0.27 | 0.47 |
O vs. (A + B + AB) | 0.55 | 0.58 | 0.69 | 0.09 |
The p values for the frequency of O and non-O blood group types between the three ethnic groups according to malaria infection and parasite density.
There was an association between the Non-O blood group of all ethnicities and malaria infections during high transmission. However, this association disappeared when the ethnic groups were considered separately (all ethnicities
This study revealed that blood group O represented the most observed phenotype among participants (40.5%), followed by blood group B (26.6%), then blood group A (25.5%), and finally the AB blood group, which is rarer (7.3%). These results are consistent with those of previous studies that reported a high frequency of group O phenotypes in areas endemic to malaria [5, 9, 10, 11, 12, 13].
Other studies have corroborated this evidence by the inverse relationship: they have reported a high prevalence of blood group A and a low prevalence of phenotypes of blood group O in colder regions where malaria is an exotic disease [5, 10, 14].
These results would confirm the hypothesis of a selective evolutionary advantage (survival) of
The results of this study according to ethnicity also showed that Fulani were less infected with malaria despite their way of life and living in the same conditions of hyperendemic transmission. These were comparable to observations in previous studies in Burkina Faso and West Africa [15, 16].
Like the study carried out in Gabon by Monbo et al. [17], this study showed a high prevalence of malaria infection in participants with blood group O compared to participants with blood groups A, B, or AB; and is in contrast to previous studies that suggested individuals of blood groups A, B, and AB is more susceptible to
Lower parasite densities in subjects of blood group O compared to non-O subjects were observed, but the differences were not statistically significant. These observations are in line with the conclusions of previous studies which have shown that patients with blood group O were associated with increased protection against parasitemia [18, 19, 20, 21, 22, 23].
These results would suggest a protective effect of the O antigen against clinical malaria. However, other explanations, such as the anti-rosette formation effect associated with blood group antigens, should also be considered [24].
In any case, this study made it possible to establish the involvement of Fulani groups against malaria infection and parasitemia. It also revealed that for all ethnicities combined, there would be a statistically significant difference in susceptibility to malaria between participants of blood groups O and participants of other blood groups (A, B, and AB).
The absence of any statistically significant difference in susceptibility to malaria in an intra-ethnic blood group analysis could be due to a sample size effect. Hence, the need for in-depth and broader epigenetic studies to accurately capture the effects of ABO blood groups in susceptibility to Pf malaria is highlighted.
The study confirmed that the Fulani group is less susceptible to
Evidence of correlations between ethnicity and blood group at risk of malaria infection would support the idea that the presumed association between blood group and malaria infection depends on the demographic distribution and characteristics of the population studied. As a result, each region of the world has a characteristic ABO phenotypic distribution, making it urgent to fully understand the biology of malaria infection through detailed studies of the interactions between the ABO blood grouping system: A critical condition for saving lives in malaria-endemic regions.
The authors have declared no conflict of interest.
BEC wrote the manuscript and agree to be accountable for all aspects of the work.
AO and SBS read and approved the final manuscript and agree to be accountable for all aspects of the work.
The study received approval from the ethical committees of the Ministry of Health of Burkina Faso.
Groupe de Recherche Action en Santé
Group Sanguin (O, A, B, AB)
Red Blood Cells
World Health Organization
This is a brief overview of the main steps involved in publishing with IntechOpen Compacts, Monographs and Edited Books. Once you submit your proposal you will be appointed a Author Service Manager who will be your single point of contact and lead you through all the described steps below.
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\n\nPlease complete the publishing proposal form. The completed form should serve as an overview of your future Compacts, Monograph or Edited Book. Once submitted, your publishing proposal will be sent for evaluation, and a notice of acceptance or rejection will be sent within 10 to 30 working days from the date of submission.
\n\n2. SUBMIT YOUR MANUSCRIPT
\n\nAfter approval, you will proceed in submitting your full-length manuscript. 50-130 pages for compacts, 130-500 for Monographs & Edited Books.Your full-length manuscript must follow IntechOpen's Author Guidelines and comply with our publishing rules. Once the manuscript is submitted, but before it is forwarded for peer review, it will be screened for plagiarism.
\n\n3. PEER REVIEW RESULTS
\n\nExternal reviewers will evaluate your manuscript and provide you with their feedback. You may be asked to revise your draft, or parts of your draft, provide additional information and make any other necessary changes according to their comments and suggestions.
\n\n4. ACCEPTANCE AND PRICE QUOTE
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\n\nThe Open Access Publishing Fee of your IntechOpen Compacts, Monograph or Edited Book depends on the volume of the publication and includes: project management, editorial and peer review services, technical editing, language copyediting, cover design and book layout, book promotion and ISBN assignment.
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. 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From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. 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Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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The literature source was Web of Science and SSCI, SCI-EXPANDED, A&HCI, CPCI-S, CPCI-SSH, and ESCI indexes. Fifty-two articles were reviewed; however, 14 of them were not been included in the study. As a result, 38 articles were examined. Level of education, field of education, and material types of AR used in education and reported educational advantages of AR have been investigated. All articles are categorized according to target groups, which are early childhood education, primary education, secondary education, high school education, graduate education, and others. AR technology has been mostly carried out in primary and graduate education. “Science education” is the most explored field of education. Mobile applications and marker-based materials on paper have been mostly preferred. The major advantages indicated in the articles are “Learning/Academic Achievement,” “Motivation,” and “Attitude”.",book:{id:"6543",slug:"state-of-the-art-virtual-reality-and-augmented-reality-knowhow",title:"State of the Art Virtual Reality and Augmented Reality Knowhow",fullTitle:"State of the Art Virtual Reality and Augmented Reality Knowhow"},signatures:"Rabia M. Yilmaz",authors:[{id:"225838",title:"Dr.",name:"Rabia",middleName:null,surname:"Yilmaz",slug:"rabia-yilmaz",fullName:"Rabia Yilmaz"}]},{id:"63639",doi:"10.5772/intechopen.81086",title:"Cooperative Learning: The Foundation for Active Learning",slug:"cooperative-learning-the-foundation-for-active-learning",totalDownloads:3491,totalCrossrefCites:18,totalDimensionsCites:25,abstract:"The role of instructors is evolving from the presenter of information to the designer of active learning processes, environments, and experiences that maximize student engagement. The more active a lesson, the more students tend to engage intellectually and emotionally in the learning activities. Cooperative learning is the foundation on which many of the active learning procedures are based. Cooperative learning is the instructional use of small groups so that students work together to maximize their own and each other’s learning. Most of the active learning procedures, such as problem-based learning, team-learning, collaborative learning, and PALS, require that students work cooperatively in small groups to achieve joint learning goals. Cooperative learning is based on two theories: Structure-Process-Outcome theory and Social Interdependence theory. Four types of cooperative learning have been derived: formal cooperative learning, informal cooperative learning, cooperative base groups, and constructive controversy. There is considerable research confirming the effectiveness of cooperative learning. To be cooperative, however, five basic elements must be structured into the situation: positive interdependence, individual accountability, promotive interaction, social skills, and group processing.",book:{id:"6929",slug:"active-learning-beyond-the-future",title:"Active Learning",fullTitle:"Active Learning - Beyond the Future"},signatures:"David W. Johnson and Roger T. 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Currently, you can hear a lot of criticism that the classroom has not changed significantly compared to the last century or even like two centuries ago. Do the teachers succeed in modern changes? The purpose of the chapter is to summarize the current changes in didactics for the use of innovative teaching methods and study the understanding of changes by teachers. In this chapter, we consider four areas: the expansion of the subject of pedagogy, environmental approach to teaching, the digital generation and the changes taking place, and innovation in teaching. The theory of education, figuratively speaking, has two levels. At the macro-level, in the “education-society” relationship, decentralization and diversification, internationalization of education, and the introduction of digital technologies occur. At the micro-level in the “teacher-learner” relationship, there is an active mix of traditional and innovative methods, combination of an activity approach with an energy-informational environment approach, cognition with constructivism and connectivism.",book:{id:"5980",slug:"new-pedagogical-challenges-in-the-21st-century-contributions-of-research-in-education",title:"New Pedagogical Challenges in the 21st Century",fullTitle:"New Pedagogical Challenges in the 21st Century - Contributions of Research in Education"},signatures:"Aigerim Mynbayeva, Zukhra Sadvakassova and Bakhytkul\nAkshalova",authors:[{id:"201997",title:"Dr.",name:"Aigerim",middleName:null,surname:"Mynbayeva",slug:"aigerim-mynbayeva",fullName:"Aigerim Mynbayeva"},{id:"209208",title:"Dr.",name:"Zukhra",middleName:null,surname:"Sadvakassova",slug:"zukhra-sadvakassova",fullName:"Zukhra Sadvakassova"},{id:"209210",title:"Dr.",name:"Bakhytkul",middleName:null,surname:"Akshalova",slug:"bakhytkul-akshalova",fullName:"Bakhytkul Akshalova"}]},{id:"59468",doi:"10.5772/intechopen.74344",title:"Virtual and Augmented Reality: New Frontiers for Clinical Psychology",slug:"virtual-and-augmented-reality-new-frontiers-for-clinical-psychology",totalDownloads:2364,totalCrossrefCites:13,totalDimensionsCites:21,abstract:"In the last decades, the applied approach for the use of virtual reality (VR) and augmented reality (AR) on clinical and health psychology has grown exponentially. These technologies have been used to treat several mental disorders, for example, phobias, stress-related disorders, depression, eating disorders, and chronic pain. The importance of VR/AR for the mental health field comes from three main concepts: (1) VR/AR as an imaginal technology, people can feel “as if they are” in a reality that does not exist in external world; (2) VR/AR as an embodied technology, the experience to feel user’s body inside the virtual environment; and (3) VR/AR as connectivity technology, the “end of geography’. In this chapter, we explore the opportunities provided by VR/AR as technologies to improve people’s quality of life and to discuss new frontiers for their application in mental health and psychological well-being promotion.",book:{id:"6543",slug:"state-of-the-art-virtual-reality-and-augmented-reality-knowhow",title:"State of the Art Virtual Reality and Augmented Reality Knowhow",fullTitle:"State of the Art Virtual Reality and Augmented Reality Knowhow"},signatures:"Sara Ventura, Rosa M. Baños and Cristina Botella",authors:[{id:"106036",title:"Dr.",name:"Rosa Maria",middleName:null,surname:"Baños",slug:"rosa-maria-banos",fullName:"Rosa Maria Baños"},{id:"227763",title:"Ph.D.",name:"Sara",middleName:null,surname:"Ventura",slug:"sara-ventura",fullName:"Sara Ventura"},{id:"229056",title:"Dr.",name:"Cristina",middleName:null,surname:"Botella",slug:"cristina-botella",fullName:"Cristina Botella"}]},{id:"64583",doi:"10.5772/intechopen.81714",title:"Evaluating a Course for Teaching Advanced Programming Concepts with Scratch to Preservice Kindergarten Teachers: A Case Study in Greece",slug:"evaluating-a-course-for-teaching-advanced-programming-concepts-with-scratch-to-preservice-kindergart",totalDownloads:1422,totalCrossrefCites:13,totalDimensionsCites:18,abstract:"Coding is a new literacy for the twenty-first century, and as a literacy, coding enables new ways of thinking and new ways of communicating and expressing ideas, as well as new ways of civic participation. A growing number of countries, in Europe and beyond, have established clear policies and frameworks for introducing computational thinking (CT) and computer programming to young children. In this chapter, we discuss a game-based approach to coding education for preservice kindergarten teachers using Scratch. The aim of using Scratch was to excite students’ interest and familiarize them with the basics of programming in an open-ended, project-based, and personally meaningful environment for a semester course in the Department of Preschool Education in the University of Crete. For 13 weeks, students were introduced to the main Scratch concepts and, afterward, were asked to prepare their projects. For the projects, they were required to design their own interactive stories to teach certain concepts about mathematics or physical science to preschool-age students. The results we obtained were more satisfactory than expected and, in some regards, encouraging if one considers the fact that the research participants had no prior experiences with computational thinking.",book:{id:"6936",slug:"early-childhood-education",title:"Early Childhood Education",fullTitle:"Early Childhood Education"},signatures:"Stamatios Papadakis and Michail Kalogiannakis",authors:null}],mostDownloadedChaptersLast30Days:[{id:"58060",title:"Pedagogy of the Twenty-First Century: Innovative Teaching Methods",slug:"pedagogy-of-the-twenty-first-century-innovative-teaching-methods",totalDownloads:8832,totalCrossrefCites:17,totalDimensionsCites:23,abstract:"In the twenty-first century, significant changes are occurring related to new scientific discoveries, informatization, globalization, the development of astronautics, robotics, and artificial intelligence. This century is called the age of digital technologies and knowledge. How is the school changing in the new century? How does learning theory change? Currently, you can hear a lot of criticism that the classroom has not changed significantly compared to the last century or even like two centuries ago. Do the teachers succeed in modern changes? The purpose of the chapter is to summarize the current changes in didactics for the use of innovative teaching methods and study the understanding of changes by teachers. In this chapter, we consider four areas: the expansion of the subject of pedagogy, environmental approach to teaching, the digital generation and the changes taking place, and innovation in teaching. The theory of education, figuratively speaking, has two levels. At the macro-level, in the “education-society” relationship, decentralization and diversification, internationalization of education, and the introduction of digital technologies occur. 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Teachers can improve their professional abilities through principals’ instructional supervision and their own knowledge-management (KM) behaviors to benefit students. Thus, this chapter analyzes the relationship among principals’ instructional supervision, teachers’ KM, and teachers’ professional development. The author believes that principals’ instructional supervision and effective KM can facilitate the professional development of teachers. 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This chapter explores these needs using a combination of lived experiences and literature review that captured a meta-analysis of research trends on e-learning. While trends in Teacher Education indicate progression towards adoption of technology, there are disparities between the theory and practice. Evidence from recent research and reports; and the recollected experiences confirmed knowledge, competence, skills and pedagogical gaps in the implementation of online learning, that have been exacerbated by COVID-19. The researcher recommends that teacher education should sensitize and train teacher trainees on how to access, analyze and use new knowledge emerging with technology; they also should be coached on how learners learn with technology and on fundamentals of the communication process. Particularly the course on educational technology, should focus on how to create and manage online courses. The 5-stage E-Moderator Model and Universal Design for Learning (UDL) are recommended as effective pedagogical scaffold for online teaching.",book:{id:"10229",slug:"teacher-education-in-the-21st-century-emerging-skills-for-a-changing-world",title:"Teacher Education in the 21st Century",fullTitle:"Teacher Education in the 21st Century - Emerging Skills for a Changing World"},signatures:"Catherine Adhiambo Amimo",authors:[{id:"333482",title:"Dr.",name:"Catherine Adhiambo",middleName:null,surname:"Amimo",slug:"catherine-adhiambo-amimo",fullName:"Catherine Adhiambo Amimo"}]},{id:"75224",title:"Decoding the Digital Gap in Teacher Education: Three Perspectives across the Globe",slug:"decoding-the-digital-gap-in-teacher-education-three-perspectives-across-the-globe",totalDownloads:589,totalCrossrefCites:0,totalDimensionsCites:4,abstract:"Educational use of technology is regularly assessed, and results often show a gap between educational policies and what is actually practiced. This chapter will help clarify how teacher educators experience the changing educational contexts due to the digital revolution, how their meaning-making shifts, and how outside forces influence those processes. The results are based on comparative international studies. Central for this study is practitioners’ professional digital competence, their attitudes towards digital technology and the use of digital technology in education. We found that the influence and contribution of digital practice is carried out quite differently across the globe. Our research questions were: How do practitioners experience teaching in a rapidly changing context? How do attitudes change due to top-down governing of education? and What motivates teacher educators to implement digital technology?",book:{id:"10229",slug:"teacher-education-in-the-21st-century-emerging-skills-for-a-changing-world",title:"Teacher Education in the 21st Century",fullTitle:"Teacher Education in the 21st Century - Emerging Skills for a Changing World"},signatures:"Steinar Thorvaldsen and Siri Sollied Madsen",authors:[{id:"332624",title:"Associate Prof.",name:"Siri Sollied",middleName:null,surname:"Madsen",slug:"siri-sollied-madsen",fullName:"Siri Sollied Madsen"},{id:"332626",title:"Prof.",name:"Steinar",middleName:null,surname:"Thorvaldsen",slug:"steinar-thorvaldsen",fullName:"Steinar Thorvaldsen"}]},{id:"75416",title:"Self-Study Research: Challenges and Opportunities in Teacher Education",slug:"self-study-research-challenges-and-opportunities-in-teacher-education",totalDownloads:777,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"This article aims to describe what self-study research is, why self-study can be a good approach to teacher educators’ professional development and improvements in practice and highlight some challenges and opportunities in this research approach. In addition, the article will shed light on some methodological aspects related to self-study. Self-study refers to teacher educators who in an intentionally and systematically way examine their practice to improve it, based on a deeper understanding of practice, as well as the context practice takes place. In the article, I argue that engaging in self-study is a learning and development process and an approach to developing personal professionalism, collective professionalism and improvements in practice.",book:{id:"10229",slug:"teacher-education-in-the-21st-century-emerging-skills-for-a-changing-world",title:"Teacher Education in the 21st Century",fullTitle:"Teacher Education in the 21st Century - Emerging Skills for a Changing World"},signatures:"Kåre Hauge",authors:[{id:"332053",title:"Associate Prof.",name:"Kåre",middleName:null,surname:"Hauge",slug:"kare-hauge",fullName:"Kåre Hauge"}]}],onlineFirstChaptersFilter:{topicId:"265",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:141,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:124,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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She has been a faculty member at the University of California, Riverside in the School of Education since 2016. Her research focuses on translational studies to explore the reward system in ASD, as well as how anxiety contributes to social challenges in ASD. She also investigates how behavioral interventions affect neural activity, behavior, and school performance in children with ASD. She is also involved in the diagnosis of children with ASD and is a licensed clinical psychologist in California. 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Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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