\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5807",leadTitle:null,fullTitle:"Recent Improvements of Power Plants Management and Technology",title:"Recent Improvements of Power Plants Management and Technology",subtitle:null,reviewType:"peer-reviewed",abstract:"Since first AC current high-power hydropower plant was put in operation, built by Nikola Tesla and George Westinghouse in 1895 on Niagara Falls, electrification of the world has dramatically changed. The growing power demand and energy consumption in the last decades require fundamental changes in the process, power production, and services. These requirements tend to use both conventional and nonconventional energy generation in order to have power plants economically useful and environmentally friendly to the society. The goal of this textbook is to provide an up-to-date review of this important topic with specific emphasis on the current guidelines for improving overall efficiency, lowering emissions, and using large share of renewable energy.",isbn:"978-953-51-3358-2",printIsbn:"978-953-51-3357-5",pdfIsbn:"978-953-51-4734-3",doi:"10.5772/65534",price:119,priceEur:129,priceUsd:155,slug:"recent-improvements-of-power-plants-management-and-technology",numberOfPages:200,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"5f357d049b0e0c8d41243c794ef8d923",bookSignature:"Aleksandar B. Nikolic and Zarko S. Janda",publishedDate:"July 13th 2017",coverURL:"https://cdn.intechopen.com/books/images_new/5807.jpg",numberOfDownloads:13250,numberOfWosCitations:3,numberOfCrossrefCitations:1,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:9,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:13,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 28th 2016",dateEndSecondStepPublish:"October 19th 2016",dateEndThirdStepPublish:"January 15th 2017",dateEndFourthStepPublish:"April 15th 2017",dateEndFifthStepPublish:"June 14th 2017",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"19724",title:"Dr.",name:"Aleksandar",middleName:"B",surname:"Nikolic",slug:"aleksandar-nikolic",fullName:"Aleksandar Nikolic",profilePictureURL:"https://mts.intechopen.com/storage/users/19724/images/5117_n.jpg",biography:'Born in Belgrade, Serbia in 1966.\nBSc, MSc and PhD in electrical engineering in 1991,1999,2009 at University of Belgrade.\nSince 2005 Principal Technical Associate at Institute \\"Nikola Tesla\\". Project manager of several main projects at Institute.\nSince 2009 Head of Accredited Laboratory for Power Quality Testing at Institute Nikola Tesla.\nSince 2013 President of Scientific Council at Institute Nikola Tesla.\nSince 1998 IEEE Member, since 2006 IEEE Senior Member.\nSince 1995 Member of Serbian Power Electronics Society, since 2001 Member of the Board.\nSince 2001 Member of CIGRE Serbia technical committee B4 (HVDC and Power Electronics), since 2016 President of CIGRE Serbia technical committee B4.',institutionString:null,position:"President of Scientific Council",outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"151700",title:"Dr.",name:"Žarko",middleName:null,surname:"Janda",slug:"zarko-janda",fullName:"Žarko Janda",profilePictureURL:"https://mts.intechopen.com/storage/users/151700/images/5852_n.jpg",biography:"Zarko S. Janda was born in 1960. He received his Dipl. Ing., MSc, and PhD (power electronics) degrees in 1984, 1989, and 2004, respectively, from the School of Electrical Engineering, University of Belgrade, Yugoslavia, all in Electrical Engineering. He has been with the EE Institute “Nikola Tesla,” Belgrade, since 1984. He was an associate fellow at School of Electrical Engineering, University of Belgrade, Serbia, between 1993 and 2004. He was a professor at the High School of Professional Studies in Electrical Engineering and Computer Science, Belgrade, Serbia, between 2003 and 2010. Presently, he is a chairman of Serbian IEEE PES Chapter, chairperson of CIGRE-Serbia committee B4, and member of Board of the Serbian Power Electronics Society.\n\nContact: +381-64-8259-736, janda@ieent.org",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"803",title:"Power Plant Engineering",slug:"power-plant-engineering"}],chapters:[{id:"56217",title:"Introductory Chapter: Review of Current Research Trends in the Field of Power Plants",doi:"10.5772/intechopen.69980",slug:"introductory-chapter-review-of-current-research-trends-in-the-field-of-power-plants",totalDownloads:1173,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Aleksandar B. Nikolic and Zarko S. Janda",downloadPdfUrl:"/chapter/pdf-download/56217",previewPdfUrl:"/chapter/pdf-preview/56217",authors:[{id:"19724",title:"Dr.",name:"Aleksandar",surname:"Nikolic",slug:"aleksandar-nikolic",fullName:"Aleksandar Nikolic"}],corrections:null},{id:"54655",title:"Key Technical Performance Indicators for Power Plants",doi:"10.5772/67858",slug:"key-technical-performance-indicators-for-power-plants",totalDownloads:3326,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"In this chapter, we will underline the importance of the key performance indicators (KPIs) computation for power plants’ management. The main scope of the KPIs is to continuously monitor and improve the business and technological processes. Such indicators show the efficiency of a process or a system in relation with norms, targets or plans. They usually provide investors and stakeholders a better image regarding location, equipment technology, layout and design, solar and wind exposure in case of renewable energy sources and maintenance strategies. We will present the most important KPIs such as energy performance index, compensated performance ratio, power performance index, yield, and performance, and we will compare these KPIs in terms of relevance and propose a set of new KPIs relevant for maintenance activities. We will also present a case study of a business intelligence (BI) dashboard developed for renewable power plant operation in order to analyze the KPIs. The BI solution contains a data level for data management, an analytical model with KPI framework and forecasting methods based on artificial neural networks (ANN) for estimating the generated energy from renewable energy sources and an interactive dashboard for advanced analytics and decision support.",signatures:"Simona Vasilica Oprea and Adela Bâra",downloadPdfUrl:"/chapter/pdf-download/54655",previewPdfUrl:"/chapter/pdf-preview/54655",authors:[{id:"139804",title:"Prof.",name:"Adela",surname:"Bara",slug:"adela-bara",fullName:"Adela Bara"},{id:"188586",title:"Dr.",name:"Simona Vasilica",surname:"Oprea",slug:"simona-vasilica-oprea",fullName:"Simona Vasilica Oprea"}],corrections:null},{id:"55227",title:"Predictive Maintenance Based on Control Charts Applied at Thermoelectric Power Plant",doi:"10.5772/intechopen.68685",slug:"predictive-maintenance-based-on-control-charts-applied-at-thermoelectric-power-plant",totalDownloads:1555,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In this chapter, innovative predictive maintenance technique is described with the aim of highlighting the benefits of predictive maintenance compared to time-based maintenance. The proposed technique is applied to a specific problem that occurs when time-based maintenance is applied on grinding tables of the coal mill, in coal-grinding subsystem at the thermoelectric power plant ‘TEKO’, Kostolac, Serbia. Time-based maintenance provides replacement of grinding tables after certain number of working hours, but depending on the quality of the coal and grinding table itself, this replacement sometimes needs to be made before or after planned replacement. The consequences of such maintenance are great material losses incurred because of frequent shutdowns of the entire coal-grinding subsystem, as well as the possibility that the failure occurs before replacement. Innovative predictive maintenance technique described in the chapter is used for solution of this problem.",signatures:"Emilija Kisić, Željko Đurović and Vera Petrović",downloadPdfUrl:"/chapter/pdf-download/55227",previewPdfUrl:"/chapter/pdf-preview/55227",authors:[{id:"71214",title:"Prof.",name:"Željko",surname:"Đurović",slug:"zeljko-djurovic",fullName:"Željko Đurović"},{id:"198641",title:"Dr.",name:"Emilija",surname:"Kisic",slug:"emilija-kisic",fullName:"Emilija Kisic"},{id:"198751",title:"Dr.",name:"Vera",surname:"Petrovic",slug:"vera-petrovic",fullName:"Vera Petrovic"}],corrections:null},{id:"54995",title:"Model Development for Analysis of Steam Power Plant Reliability",doi:"10.5772/intechopen.68285",slug:"model-development-for-analysis-of-steam-power-plant-reliability",totalDownloads:1402,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The graph theoretical analysis and a graph’s characteristic polynomial are deployed as the basis for a system approach employed to develop a model for estimating the reliability index and evaluating the availability index for a coal‐fired generating power station. In this research, the coal‐fired generating station system is divided into six sub‐systems. Elementary to evaluating the reliability (estimate) of the said system is the consideration of all the sub‐systems and their interrelations. Approximate reliability attributes of the graph are used to model the approximate reliability of the coal‐fired generating station. Sub‐system reliability is represented by the nodes in the graph, and the links represent the reliability of interrelations of these sub‐systems. Computing a graph’s characteristic polynomial using three different methods, namely, the linearly independent cycles, the figure equation and the adjacent matrix, the approximate reliability of the system is determined. Three methods are used, for comparison purposes, as estimating reliability is always an imperfect endeavour. The methodology proposed in this study is illustrated step‐by‐step with the help of examples.",signatures:"Bernard Tonderayi Mangara",downloadPdfUrl:"/chapter/pdf-download/54995",previewPdfUrl:"/chapter/pdf-preview/54995",authors:[{id:"196898",title:"Dr.",name:"Bernard Tonderayi",surname:"Mangara",slug:"bernard-tonderayi-mangara",fullName:"Bernard Tonderayi Mangara"}],corrections:null},{id:"55841",title:"Risk Assessment of NPP Safety in Case of Emergency Situations on Technology",doi:"10.5772/intechopen.68772",slug:"risk-assessment-of-npp-safety-in-case-of-emergency-situations-on-technology",totalDownloads:1342,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"The last accidents of the nuclear power plant (NPP) in Chernobyl and Fukushima give us the new inspiration to verify the safety level of the NPP structures. This paper presents the new requirements to test the safety and reliability of the NPP structures due to the recent accidents in the world. The IAEA in Vienna required in the document ‘Stress tests’ the verification of the safety of the NPP structures under impact of the extreme loads as the earthquakes, the extreme climatic actions and the technology accidents. The new recommendations to load combinations and design criteria were defined. The risk assessment to verify the safety and reliability of the NPP structures based on probabilistic and nonlinear analysis is presented. The uncertainties of material model (behaviour of the reinforcement and liner, concrete cracking and crushing), degradation effects, the loads level (dead and live loads, extreme climatic and accidental temperature and overpressure) as well as other effects following from the inaccuracy of the calculated model and numerical methods were taken into account in the response surface method (RSM) method. The results of the deterministic and probabilistic analysis of the NPP structures are presented.",signatures:"Juraj Králik",downloadPdfUrl:"/chapter/pdf-download/55841",previewPdfUrl:"/chapter/pdf-preview/55841",authors:[{id:"139600",title:"Prof.",name:"Juraj",surname:"Králik",slug:"juraj-kralik",fullName:"Juraj Králik"}],corrections:null},{id:"55229",title:"Analysis of the Spatial Separation Effects of Thorium/Uranium Fuels in Block‐Type HTRs",doi:"10.5772/intechopen.68671",slug:"analysis-of-the-spatial-separation-effects-of-thorium-uranium-fuels-in-block-type-htrs",totalDownloads:1279,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"With the rapid development of nuclear energy, thorium has been gaining attention because of its abundant reserves and excellent physical properties. Compared with light-water reactors, block-type high temperature gas cooled reactors (HTRs) are a better choice for thorium-based fuel for higher burnup and harder neutron spectrum. When using thorium in block-type HTRs, the composition and spatial distribution of thorium/uranium fuels are two determined factors of nuclear performance. Four spatial separation levels of thorium/uranium fuels, no separation level, TRISO level, channel level, and block level, are defined for the block-type thorium-fueled HTRs. A two-step calculation scheme was used to obtain the neutronic performance, including the initial inventory of U-235, effective multiplication factor, and average conversion ratio. Based on these data, the fuel cycle cost of different spatial separation levels can be calculated by the levelized lifetime cost method as a function of thorium content. The fuel cycle cost changes with the same trend as the initial inventory of U-235 in the reactor cores because the latter determines 70% of the total cost. When the thorium content is constant, the initial inventory of U-235 decreases with the increase of the spatial separation level because spatial self-shielding effect is strengthened by the latter.",signatures:"Ming Ding and Jie Huang",downloadPdfUrl:"/chapter/pdf-download/55229",previewPdfUrl:"/chapter/pdf-preview/55229",authors:[{id:"201457",title:"Dr.",name:"Ming",surname:"Ding",slug:"ming-ding",fullName:"Ming Ding"},{id:"201458",title:"Mr.",name:"Jie",surname:"Huang",slug:"jie-huang",fullName:"Jie Huang"}],corrections:null},{id:"55019",title:"Spatial Aspects of Environmental Impact of Power Plants",doi:"10.5772/intechopen.68283",slug:"spatial-aspects-of-environmental-impact-of-power-plants",totalDownloads:1315,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Strategic Environmental Assessment (SEA) is one of the key instruments for implementing sustainable development strategies in planning in general, namely for analysing and assessing the spatial development concepts, in this case in the field of energy and planning of power plants. The SEA in energy sector planning has become a tool for considering the benefits and consequences of the proposed changes in space, also taking into account the capacity of space to sustain the implementation of the planned activities. This chapter examines the multi-criteria evaluation (MCE) method for carrying out an SEA for the power plants in Energy Sector Development Strategy of the Republic of Serbia (case study). The MCE method has found its use in the analysis and assessment of the energy sector spatial impacts on the environment and elements of sustainable development and, in this context, also considering the importance of impacts, spatial dispersion of impacts, their probability and frequency of occurrence, along with the elaboration of the obtained results in a specific, simple and unambiguous way. The chapter focuses on the consideration of aspects of environmental impact of all kinds of power plants, without taking into account the details regarding other aspects of energy sector development that are dealt with in the case study.",signatures:"Boško Josimović and Saša Milijić",downloadPdfUrl:"/chapter/pdf-download/55019",previewPdfUrl:"/chapter/pdf-preview/55019",authors:[{id:"125578",title:"Dr.",name:"Bosko",surname:"Josimovic",slug:"bosko-josimovic",fullName:"Bosko Josimovic"},{id:"200736",title:"Dr.",name:"Sasa",surname:"Milijic",slug:"sasa-milijic",fullName:"Sasa Milijic"}],corrections:null},{id:"54413",title:"Scalable, Self‐Contained Sodium Metal Production Plant for a Hydrogen Fuel Clean Energy Cycle",doi:"10.5772/67597",slug:"scalable-self-contained-sodium-metal-production-plant-for-a-hydrogen-fuel-clean-energy-cycle",totalDownloads:1860,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"In this chapter, we present a detailed design study of a novel, scalable, self‐contained solar powered electrolytic sodium (Na) metal production plant meant to enable a hydrogen (H2) fuel, sustainable, closed clean energy cycle. The hydrogen fuel is generated on demand inside a motor vehicle using an efficient hydrogen generation apparatus that safely implements a controlled chemical reaction between either ordinary salinated (sea) or desalinated (fresh) water and sodium metal. The sodium hydroxide (NaOH) byproduct of the hydrogen generating chemical reaction is stored temporarily within the hydrogen generation apparatus and is recovered during motor vehicle refueling to be reprocessed in the self‐contained sodium (Na) metal production plant. The electric power for NaOH electrolysis is produced using photovoltaic (PV) device panels spatially arrayed and electrically interconnected on a tower structure that maximizes the use of scarce land area. Our analysis shows that the scalable, self‐contained sodium (Na) metal production plant using solar power is technically and economically viable for meeting the hydrogen fuel clean energy needs of all the motor vehicles in the U.S.A. by constructing approximately 450,000 scalable, self‐contained sodium (Na) metal production plant units in the southwestern desert region that includes West Texas, New Mexico, Arizona and Southern California.",signatures:"Alvin G. Stern",downloadPdfUrl:"/chapter/pdf-download/54413",previewPdfUrl:"/chapter/pdf-preview/54413",authors:[{id:"199190",title:"Dr.",name:"Alvin",surname:"Stern",slug:"alvin-stern",fullName:"Alvin Stern"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6332",title:"Thermal Power Plants",subtitle:"New Trends and Recent Developments",isOpenForSubmission:!1,hash:"616ffd286d75ca988abf59b408880a98",slug:"thermal-power-plants-new-trends-and-recent-developments",bookSignature:"Pawe? 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",isbn:"978-1-80356-990-1",printIsbn:"978-1-80356-989-5",pdfIsbn:"978-1-80356-991-8",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"f8092a491f68ca0b63cc6d40936a010a",bookSignature:"Dr. Arli Aditya Parikesit",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11690.jpg",keywords:"Molecular Docking, Molecular Dynamics, Biomolecular Modeling, Homology Modeling, In Vitro Drug Testing, In Vivo Drug Testing, Structural Biology, Nano Delivery, Prodrug, Smart Drug, Liposome, Wet Lab",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 12th 2022",dateEndSecondStepPublish:"June 22nd 2022",dateEndThirdStepPublish:"August 21st 2022",dateEndFourthStepPublish:"November 9th 2022",dateEndFifthStepPublish:"January 8th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"14 days",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"A researcher in transcriptomics, immunoinformatics, and structural bioinformatics, ISBB and APBIONET member, currently involved in COVID-19 Drug and Vaccine design. 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In order to pursue a degree in Bioinformatics, he accepted an offer from DAAD (German Academic Exchange Service) to conduct doctorate research at the Bioinformatics Group, Faculty of Informatics and Mathematics, University of Leipzig, Germany. His doctoral research is focused on the utilization of modern protein domain annotation techniques to the three domains of life. In addition, Dr. Arli is also an expert on immunoinformatics, bioinformatics algorithm, structural bioinformatics, in silico drug design, and in silico transcriptomics. 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This is because the main causes of failures change with time. The early failures (stage I) are mostly caused by errors in design, manufacture, assembly, or building process or due to hidden defects, and the instant of their occurrence cannot be predicted. The failures in stage II (useful life) arise from external reasons (random overloading, collision with another object, climatic events, and errors of personnel) and also cannot be predicted. Only if the pertinent failure rate is known one can predict approximately how often failures can be expected and take suitable measures to mitigate their effects.
The failures in stage III (aging and wear-out) arise due to the internal “weakness” of the object and appear after some time of operation even under appropriate conditions of use. Many objects fail due to wear, fatigue, creep, corrosion, or other processes of gradual deterioration. Fortunately, in such cases a possibility exists to predict (with higher or lower accuracy) the time when the object is about to fail, provided that the relationship between the load intensity and the rate of deterioration is known. Two principal ways exist:
If the basic mechanism of degradation is known, one can express the deterioration rate as a function of the characteristic load and then derive a formula for the calculation of the time to failure. For the known load, the time to failure can thus be predicted in advance (e.g. during the design stage). Vice versa, it is possible to find such dimensions of loaded parts, which will guarantee an acceptably low rate of deterioration and thus the demanded life.
Due to deterioration, the load response of many objects also gradually changes. If a quantity characterizing the degradation is known (e.g. the magnitude of vibrations), it is possible to monitor its time development in the real object. These data can be extrapolated, and the time can be predicted at which the characteristic quantity reaches the critical value.
Both approaches may be combined. During design, the time to failure can be predicted, and during operation, this prediction is updated with respect to the actual time history of the operation and response. The object is never allowed in operation until the instant of expected failure. At a reasonable time before it, a check of its condition is made and a suitable time for repair or next inspection is proposed.
Both cases will be discussed here in detail.
A typical example is the fatigue of metallic parts under cyclic or periodic loading. If the characteristic stress is higher than the so-called fatigue limit, a small crack arises in the component after some time of operation and grows slowly, and when it reaches the critical size, the component breaks. The number of cycles to failure
Equation (1) can be rearranged to obtain the stress amplitude or range corresponding to the demanded life:
This formula can be used in the dimensioning of a component for a certain prescribed life.
Equation (1) does not assume any previous damage to the component. Sometimes, however, one or more cracks or similar defects are present in the body from the beginning. The behavior of bodies with cracks is studied by fracture mechanics [1 - 4]. Crack growth is influenced not only by the stress, but also by the crack size (Fig. 2). Both quantities form together a very important parameter, called
Body with a crack. Characteristic modes of crack opening.
In components exposed to periodic loading, the crack can grow very slowly even if the stress intensity factor is lower than the critical value. The period of subcritical crack growth can last from minutes to years and can be predicted via the relationship between the crack velocity and the stress intensity factor. The crack velocity
d
Fast fracture occurs if the stress intensity factor attains critical value
Crack growth velocity
In some materials, fatigue occurs even under constant load. Examples are glass and some ceramics as well as some metals in a corrosive environment. In this case, called static fatigue, it is possible to express the time to failure
The relationship for the time to failure is similar to Equation (1) or (6) with the stress amplitude
the time to failure in rotating parts can be expressed by means of a number of revolutions. Equation (8) is the simplest formula; the relationship in some cases is more complex. For details, the reader is referred to a special literature, for example [1 - 4].
The consequences of random variability of load and uncertainties in the determination of parameters in fatigue equation will be dealt with in Chapter 19.
Until now, we have assumed a constant load amplitude. Often, it varies. Figure 4 depicts a regular operation regime of a machine, with four characteristic stages. Examples of irregular or random regime are bogie of a car or components of an engine. In all these cases, the concept of
Variable loading (a schematic for damage accumulation).
The basic idea of the
For example, if a component could sustain 1000 loading cycles until failure, then one loading cycle has exhausted 1/1000 of its fatigue life. Failure occurs if
If the loading pattern is more complex, consisting of various loading blocks, each with different amplitude and different number of loading cycles (Fig. 4), the total damage is obtained as the sum of damages caused during the individual blocks,
Again, failure occurs if
Special procedures have been developed for cases where the load changes irregularly, in a random way, such as constructions of airplanes or cars. For more, see [1 - 3].
The gradual deterioration of many objects can be characterized by various quantities, such as amplitude of vibrations, noise level, deformation under load, or loss of material by wear or corrosion. The pertinent quantity (
Time course of gradual deterioration (e.g. wear) – a schematic.
When dealing with the constants of a fatigue curve, taken from the material data sheets, or with the constants of a curve showing the development of a certain parameter with time, one must not forget that they are only approximate, obtained by testing several samples only. One should always be aware of the scatter of individual values. Actually, each curve corresponds to a particular specimen despite the same test conditions. The testing of many samples would thus give a group or distribution of
Scatter of fatigue values and curves.
When taking the constants for calculations from a material database or literature, one should therefore know how they were obtained and to what conditions they correspond. Scatter also influences the values of other material parameters, such as strength, fracture toughness
The uncertainty due to the scatter of experimental data must always be considered in the predictions of the time to failure or the alert time. The higher uncertainty, the longer time before reaching the critical state should an inspection be made. We return to this topic in Chapter 19.
A component is loaded by the sinusoidal mechanical stress of the amplitude
Task. Determine the number of cycles to failure
Solution.
Determine the allowable stress amplitude for the component from Example 1.6/1 so that the component can sustain
Solution. The rearrangement of the
Note. In reality, some factor of safety would be used, either for increasing the number of cycles to failure or for reducing the allowable stress. The stress can be reduced by more ample dimensioning.
The technical condition of a machine can be characterized by the amplitude
Task. Fit the measured data: (a) by a straight line, and (b) by exponential function and predict:
the amplitude on 14th day, and
when the amplitude will reach the critical value
Solution. The measured data were plotted using Excel. Then, the command Add Trendline was used (Fig. 7). Linear approximation (a) was:
The approximations have given the following amplitudes of vibrations on 14th day:
Vibration amplitude as a function of time (an example). Fitting by various regression functions and predictions.
One can see the big differences between the predictions done using different approximations. Caution is necessary especially for longer intervals of predictions and also with respect to the consequences of a wrong prediction.
Nature has provided innumerable examples of very efficient solutions to complex problems with seemingly simple rules. With these as inspiration, many engineering problems are tackled using bioinspired techniques. A few of bioinspired techniques are evolutionary and genetic algorithms, stigmergy, hidden Markov models, belief networks, neural networks, etc. These are applicable in a wide variety of domains from robotics [1], communication systems, routing [2], building construction [3], scheduling, optimization, machine intelligence, etc. The brain is a very efficient computing element capable of performing complex tasks. This is possible due to massively parallel computation being performed by the vast number of cells called neurons in the brain while consuming very little energy. This has inspired a domain of algorithms and techniques called artificial intelligence (AI) where machines are programmed to learn and then solve complex tasks. The recent advances in high performance computing and theoretical advances into statistical learning methodologies have enabled a widespread use of AI techniques for tasks such as pattern recognition, natural language understanding, speech recognition, computer vision, odor recognition, machine translation, medical diagnosis, gaming, autonomous driving, path planning, autonomous robots, financial market modeling and the list goes on. Solving these kinds of problems with efficiency is not possible with the traditional computing paradigms. These algorithms are mimicking biology or are inspired from biology to tackle the above problems. For example, it is not humanly possible to have traditional software program coded to classify an image of a simple object such as a cup with reasonable accuracy, considering the innumerable variations available in terms of shape, size, color, etc. However, this is a trivial task for a human being as our brains learn to identify the salient features of an object. The inner working of the brains, especially the way it processes information is the inspiration behind a class of AI techniques called neural networks.
\nAI requires a large amount of compute power while churning through massive amounts of data. Today’s real-world tasks require different sets of AI models with different modalities to interact with each other, hence needing a large pipeline with complex data dependencies. Training is time-consuming, while needing efficient multi-accelerator parallelization. Even with such advances we are nowhere close to the compute power or the efficiency of a human brain. Human brain is still a mystery and is a very actively researched topic. Several neuron models are proposed to mimic various aspects of how the brain works with the limited understand we have up till now.
\nSpiking neural networks (SNNs) are networks made up of interconnected computing elements called neurons. SNNs try to mimic biology to incorporate the efficiencies found in nature. These neurons use spikes to communicate with each other. SNNs are third generation of neural networks [4] and are gaining popularity due to its potential for very low energy dissipation due to their event-driven and asynchronous operation. SNNs are also interesting because of their ability learn in a distributed way using a technique called Spike Timing Dependent Plasticity (STDP) learning [5]. STDP relies on sparsely encoded spiking information among local neurons. SNNs are capable of learning rich spatio-temporal information [6]. In principle, SNNs can be fault tolerant due to its ability to re-learn and adapt the connections with other neurons, akin to how the brains learn. Also SNNs can natively interface with specialized hardware sensors which mimic biological vision (Dynamic Vision Sensor) and hearing (Dynamic Audio Sensor) [7] as they directly transduce sensory information to spikes.
\nIn the rest of the chapter, a brief introduction on neuron biology and artificial neuron models is presented, followed by discussion on information representation as spikes, different learning methodologies, tools, and platforms available for simulating and implementing SNNs and finally few case studies as examples of SNN usage.
\nIn this section, a brief overview of the biological neuron processes is provided to understand the inference and learning dynamics of SNNs. A few popular neuron models are discussed at a high level to make the reader aware of the diversity of such research and its use in SNNs.
\nComplex living organisms have specialized cells called neurons, which are the fundamental unit of central nervous system. Neurons can transmit and receive signals in the form of electrical impulses. In a human brain, there are an estimated 200 billion neurons. Also, there are several different types of neurons in the body. In general, a neuron consists of a cell body or soma consisting of cell machinery, nucleus, dendrites, and an axon as shown in \nFigure 1\n.
\nNeurons (by unknown author, licensed under CC BY-SA
The dendrites receive information from other neurons, and this causes a voltage buildup on the cell body. When this membrane potential reaches a certain threshold, an electrical impulse is generated, and the axon transmits this spike away from the cell body to other neurons. After a spike is generated, the neuron returns to a lower potential called resting potential. Also, immediately after a spike is generated, the neuron cannot generate another spike for a short duration called the refractory period. The axon terminates at axon terminals which interface with dendrites of other neurons; this is called as a synapse. A synapse is connection between a pre synaptic neuron (which generates electrical impulse) and a postsynaptic neuron (receives the spike information) as shown in \nFigure 1\n. The synapse is not a direct connection, instead it consists of a gap called synaptic cleft as shown in \nFigure 2\n. Discussion about astrocyte cells is presented later in Section 4.5.
\nNeuronal synapse along with astrocyte cells (author created).
When an electrical impulse reaches the synapse, the presynaptic neuron releases certain chemicals called neurotransmitters into the synaptic cleft. The postsynaptic neuron picks up these neurotransmitters eventually causing the postsynaptic neurons membrane potential to either increase or decrease. The brain learns by strengthening or weakening the existing synaptic connections or by making new synaptic connections or dissolving those which are no longer needed. In this way, the synapses make the brain plastic and provide the ability to learn. Also, the strength of the synapse also matters for learning as it can modulate the amount of neurotransmitters released in the synaptic cleft resulting in a stronger or weaker synapse and depending on the type of neurotransmitters released, the synapse can be excitatory or inhibitory. An excitatory synapse is one which would increase the membrane potential of the post synaptic neuron; conversely, an inhibitory synapse would decrease the membrane potential. Based on these fundamental concepts, several researchers have proposed various neuron models over the decades. We do not yet fully understand the inner workings of brains and is still an active field of research. New neuron models are being proposed frequently as our understanding of biology increases. A few neuron models are listed below, followed by an overview of select models.
\nSome of the models proposed try to mimic biology for the purpose of understanding and modeling neuro-physiological processes and some models more oriented toward computing purposes. A few of neuron models to consider are McCulloch and Pitts [8], Hodgkin-Huxley [9], Perceptron [10], Izhikevich [11] Integrate and fire [12], Leaky integrate-and-fire [13], Quadratic integrate-and-fire [14], Exponential integrate-and-fire [15], Generalized integrate-and-fire [16], Time-varying integrate-and-fire model [17], Integrate-and-fire or burst [18], Resonate-and-fire [19], and Bayesian neuron model [20].
\nHodgkin and Huxley [9] studied the giant axon of the squid and found currents induced by different types of ions namely sodium ions, potassium ions, and leakage current due to calcium ions. The cell consists of voltage-dependent ion channels which regulate the concentration of these ions across the cell membrane. For the sake of simplicity, at a high level, the total membrane current is the sum of current induced by membrane capacitance and the ion channel currents as shown in Eq. (1), where \n
They also describe gating variables to control the ion channels and the resting potential of the cell. When the membrane potential increases significantly above the resting potential, the gating variable activates and then deactivates the channels resulting in a spike. This is a very simplified model and has several limitations [21].
\nIzhikevich neuron model [11] is more biologically plausible as shown in equations below.
\nWhere \n
Izhikevich neuron model [
Over time, if a biological neuron does not spike, then any potential builtup would dissipate. This phenomenon is modeled by several variations of Leaky Integrate and Fire (LIF) models. LIF neuron model is very popular due to its ease of implementation as a software model and for developing dedicated hardware models. Digital hardware implementation is more popular than the analog variants, again due to its simplicity of design, fabrication, and scalability.
\nA typical generic LIF model adapted for discrete implementation [22] is represented as:
\nSynaptic integration
\nLeak integration
\nThreshold, fire and reset
\nWhere \n
Bayesian neuron (BN) model is proposed in [20]. BN model is a stochastic neuron model. When the membrane potential reaches the threshold a BN model fires a spike stochastically. It generates a spike based on a Poisson process where neuron \n
Where the weight of the synapse between
To generate a Poisson process with time-varying rate \n
\n\n
SNNs understand the language of spikes, and it is necessary to decide what is the best possible way to represent real-world data to achieve best possible training of the network and efficient inference. Different coding techniques model different aspects of input spectrum. Some of the spike coding techniques are described below to get an intuition of signal representation using spikes.
\nWith rate coded spike trains, the information is encoded in the number of spikes over a specified temporal window. The firing rate \n
Evidence of rate coding is experimentally shown in sensory and motor systems [24]. The number of spikes emitted by the receptor neuron increases with the force applied to the muscle.
\nIf the rate \n
Therefore, the instantaneous firing rate is
\nThe expected number of spikes for the temporal window \n
To summarize, the experimental procedure of counting spikes over a time \n
The Peri-stimulus-time histogram and the average time-dependent firing rate [
A spike train \n
The instantaneous firing rate is the expectation over trials.
\nAn empirical estimate of the instantaneous firing rate can be deduced as shown in Eq. (18). It implies that the PSTH as described above represents the instantaneous firing rate.
\nThe average firing rate can be computed for a single neuron, or for a population of neurons representing a class over a single run or over several trials. Rate coding over a time window is suitable for representing the strength of stimulation. On the other hand, population-based rate coding could convey the same information by employing several neurons in a shorter temporal window. The latter trades quick response over a number of neurons. There is evidence of Purkinje neurons demonstrating information coding which is not just firing rate but also the timing and duration of nonfiring, quiescent periods [25, 26].
\nIf the time of spike occurrence in a temporal window carries information, then such coding is referred to as temporal coding. In such coding schemes the quiescent periods and the spiking time both carry information. There are several evidences in biology demonstrating this behavior [27, 28]. A typical temporal code is shown in \nFigure 5A\n, where the time interval of spike to start of stimulus caries information. These are sometimes referred to as pulse codes. Another variation is Rank Order Coding, which uses the relative timing of spikes across a population of cells. Rank order codes look at time to spike across the neuron population and a rank order can be implied from the firing order among the neurons in the population as described in \nFigure 5B\n.
\nDifferent strategies for information coding with spikes (refer to [
There is evidence suggesting that simple temporal averaging of firing rate is too simplistic to model neuronal circuits in the brain [30]. To address some of the shortcomings, several derivations of coding schemes based on different combinations of above concepts are widely used. Few of the common schemes and some task specific coding schemes are Rate code, Time to spike code, Time-to-first-spike: Latency code [31], Reverse time to spike code, Weighted spike code [32], Burst code [33], Population code, Population rate, Rank order code [34], Phase-of-firing code [35, 36], Place code [37], etc. \nFigure 5\n summarizes a few coding strategies. These coding schemes require appropriate algorithms for converting real-world data to spikes and vice versa. A few common conversion techniques are discussed in the next section.
\nSNNs understand the language of spikes; therefore, we must transform the real-world data to appropriate spike representation and subsequently transform the output spikes to real-world formats for human consumption. There are several encoding and decoding algorithms available to achieve this goal. Several heuristics are also employed. Some of the coding techniques mentioned above infer a specific coding/decoding scheme. Based on the nature of application (such as images, audio, video, financial data, user activity data), one must choose which is the best approach.
\nImage pixel values are binned and proportional firing rates are assigned to different neurons in the receptive fields for each pixel neuron, hence generating random process with rate coding [38]. Since spikes have no polarity positive and negative spike, subchannels can be used to represent richer encoding of data. In threshold-based schemes, a spike is generated when the input signal intensity crosses a threshold. Real numbers are compared against different thresholds, and positive and negative spikes are produced accordingly which are rate coded [39]. BSA algorithm for encoding and decoding [40] is used for modeling brain-machine interfaces and neurological processes in the brain. The work presented by the authors of [41] provides details on step-forward (SF), and moving-window (MW) encoding schemes. In SF scheme, a baseline \n
Hebb postulated that synaptic efficacy increases from a presynaptic neuron if it repeatedly assists the post synaptic neuron [42]. This forms the fundamentals of STDP rule for learning. STDP mimics biology where a synapse is strengthened when a presynaptic spike occurs before a post synaptic spike in close intervals, this is called Long-Term Potentiation (LTP). On the other hand, the synapse is weakened if the post synaptic neuron fires before the presynaptic neuron in close intervals. This is called as Long-Term Depression (LTD). In biology neurons are highly selective due to lateral inhibition. This allows for them to learn discriminatory and unique features in an unsupervised manner leading to an emergent Winner Take All (WTA) behavior. Apart from this the biological system demonstrates homeostasis to maintain overall stability. These are key principles in SNN modeling. There are several ways to achieve WTA and homeostasis behavior, some directly modify the neuron state, others use neural circuits. One such example with a scalable neural circuit [43] is shown in \nFigure 6\n. A WTA network consists of inhibitor neurons suppressing the activation of other lateral symbol neurons as shown in \nFigure 6(a)\n. To assist in homeostasis a normalization of the excitations of one neural circuit compared to others can be achieved using a Normalized Winner Take All (NWTA) network as shown in \nFigure 6(b). Where an upper limit (UL) neuron uniformly inhibits all symbol neurons if they are firing beyond a desirable high threshold. On the contrary if the symbol neurons are firing below a desired low threshold, then the lower limit (LL) neuron triggers an excitor (Ex) neuron to uniformly boost the firing rate of all symbol neurons. In this manner all independent neural circuits within an SNN fire in the dynamic range of excitations of the overall network. Both hard and soft WTA behavior can be achieved based on the amount of inhibition generated. In Hard WTA only one symbol neuron is active whereas in soft WTA more than one symbol neuron is active providing richer context.
\n(a) Winner take all network (b) normalized winner take all network [
SNNs can learn in both unsupervised and supervised modes. WTA concepts are essential part of unsupervised learning as the neuron with highest excitation inhibits the lateral neurons the strongest hence enabling it to preferentially pick up unique features. Unsupervised learning is possible by employing a teacher signal which excites the specific neurons to fire thereby allowing it to learn the features represented by the input signal. STDP based learning has its advantages of being able to model spatio-tempotal dynamics. Where the spatial component refers to localized activity/learning and temporal component refers to additional information representation by the spike intervals along the time axis. With the constant advances in SNN research, native STDP based rules are catching up to the more popular backpropagation-based learning methods used in Artificial Neural Networks (ANN). STDP lends itself for efficient localized and distributed learning, which is a huge advantage over other learning methods. Also SNNs can be adapted to model memories in the form of Long Short-Term Memory networks [39] which shows that recurrent learning behavior is also possible. The following sub-sections discus few learning rules used in training SNNs along with a brief introduced to backpropagation-based learning.
\nA classic STDP rule [44] is shown in \nFigure 7\n. The STDP curve tries to approximate experimentally observed behavior.
\nClassic STDP curve [
Here \n
Where \n
There are two broad categorizations of STDP rules, additive and multiplicative STDP [38]. Multiplicative rule tends to be more stable than additive rule. In additive rules the weight changes are independent of current weight and requires additional constraints to keep the values in operating bounds. These weight changes however produce bimodal distribution resulting in strong competition. In multiplicative rule presented in [38], the weight change is inversely proportional to the current weight making it inherently stable and resulting in a unimodal distribution. This distribution lacks synaptic competition which is desirable for learning discriminative features. For such rules, competition must be introduced in a different method. The stable multiplicative rule is further explored below and simplified for efficient implementation. Here the STDP rule is modeled such that weight change of a synapse has an exponential dependence on its current weight as shown in \nFigure 8\n (a). Update for the weight \n
(a) Current weight vs weight change for learning rates (b) STDP windows (c) Comparison of Exp, 2P and Q2PS STDP rules [
If
\nthen,
\nIf
\nthen,
\nWhere \n
The Exp STDP rule requires an exponential and a multiplication operation for both LTP and LTD for each synapse. From the perspective of efficient digital hardware implementation these are expensive operations in terms of circuit area and computation time. Quantized 2-power shift rule (Q2PS), which approximates the Exp rule in Eq. (20) and Eq. (21) by removing both multiplication and exponential. The approximation is summarized in Eq. (22) and Eq. (23).
\nIf
\nIf
\nwhere \n
where \n
With the tremendous advances in the field of ANNs, a growing body of research is available on various statistical learning algorithms. ANNs are inspired by biology but they do not mimic it. ANNs are made up of artificial neuron models specifically tuned for compute purposes and model a biological neuron at a very abstract level. An artificial neuron computes weighted sum of input signals and then an activation function computes the neuron output. In these networks’ neurons transmit signals as real numbers. ANNs compute inference by transmitting the neuron signals in the forward direction. The learning happens usually via a method called Backpropagation. This algorithm computes the gradients based on the error signal produced by a cost function and propagates it back for each layer of neurons in the neural network. The weight updates are usually made using gradient descent algorithms. There are many flavors of gradient descent algorithms available in the literature. For back propagation to work the activation function must be differentiable. Unlike SNNs, where a spike is not differentiable. In general, ANNs have proven to be very effective in tackling a wide variety of problems. Using these algorithms as inspiration several modified STDP rules have been researched, one among them is discussed below. This overview is a very high-level introduction to some of the terminology required to understand the following section. The reader is encouraged to explore further on this topic.
\nThe Backpropagation-STDP (BP STDP) [45] algorithm uses the number of spikes in a spike trains as an approximation for the real value of an artificial neurons excitation. They also divide the time interval into sub-intervals such that each sub-interval contains zero or one spike.
\nIn supervised training, the weight adjustment is governed by the STDP model shown in Eq. (25) and Eq. (26), in conjunction with a teacher signal. The teacher signal when applied to target neurons undergo weight change based on STDP and non-target neurons undergo weight changes based on anti-STDP. Anti-STDP is the opposite of STDP where LTP and LTD equations are swapped. Target neurons are identified by spike trains with maximum spike frequency (\n
A target neuron would generate a spike \n
Stigmergy is a methodology where several independent agents produce an emergent behavior through indirect interaction among themselves. This is facilitated with the help of asynchronous communication through traces left in the environment by individual agents. Stigmergy has been observed in nature and widely researched upon especially in insect colonies, these principles have been applied towards solving various engineering problems. Recent advances in neuroscience have shown evidence of another type of cells called astrocytes working in tandem with neurons to regulate the behavior of the central nervous system [46]. Astrocytes are star shaped cells with several branches called as processes. The end of these branches called as end feet interface with a synapse by wrapping around it creating a region around the synaptic cleft called as microdomain as shown in \nFigure 2\n. Astrocytes also interface the neurons apart from the synapse providing a closed loop feedback mechanism. They also interface with other astrocytes like a synapse, instead this is called as a gap junction. Gap junction facilitates communication between astrocyte cells only through chemical means. Astrocytes are functionally very diverse and play a very important role, only a high-level concept with limited detail is introduced for understanding of relevant discussion. With the help of calcium ions as a signaling mechanism along with the help of neurotransmitters the astrocytes help regulate the efficiency of synaptic transmission. These cells play a critical role in maintaining homeostasis, modulating LTP, LTD and structural plasticity in the brain.
\nSpiking activity results in release of neurotransmitters and change in concentration among different ions in the microdomain and extra cellular space. These changes are monitored as traces for indirect communication by astrocytes. Astrocytes themselves behaving like an environment with calcium ion concentration gradients within the cell acting as a medium for other neuron agents to indirectly infer these changes. This interaction creates a feedback mechanism in an asynchronous and distributed manner [47]. \nFigure 9\n shows the emergent stigmergy pattern in the brain. Short term activity and long-term activity gets communicated over a distance to other synapses over a spatial domain. Greater the distance, lower would be the influence. The details about the stigmergy based brain plasticity is presented in [47], interested readers are encouraged to explore further. This is a relatively new discovery and extensive research is underway to understand the role of astrocytes in overall brain mechanics.
\nStigmergic interactions between astrocytes and neurons (modified from [
There are several spiking neural network simulation tools available which support biologically realistic neuron models for large scale networks. Some of the popular ones are:
\nBrian [48], is a free, open source simulator for spiking neural networks. This simulator is capable of running on several different platforms and is implemented in python making it extendable and easy to use.
\nNEST [49] is another simulator focusing on the dynamics, size and structure of neural systems both large and small. This tool is not intended for modeling the intricate biological details of a neuron.
\nNEURON [50] is simulation environment best suited for modeling individual neurons and their networks. This is popular among neuroscientists for its ability to handle complex models in a computationally efficient manner. Unlike above simulator, NEURON can handle morphological details of a neuron and is used to validate theoretical models with experimental data.
\nThe above tools are commonly used in modeling biologically realistic neuron modes. They have their own unique interfaces and low-level semantics. An effort is made to smooth things out with a tool independent API package developed on Python programming language called PyNN [51]. The PyNN framework provides API support to model SNNs at a high level of abstraction of all aspects of neuron modeling and SNN representation, including populations of neurons, connections, layers etc. Though this provides high level abstraction, it also provides the ability to program at a low level such as adjusting individual parameters at the neuron and synapse level. To make things easy PyNN provides a set of library implementation for neurons, synapses, STDP models etc. They also provide easy interfaces to model various connectivity patterns among neurons like; all-to-all, small-world, random distance-dependent etc. These APIs are simulator independent making the code portable across different supported simulation tools and neuromorphic hardware platforms. It is relatively straightforward to add support to any custom simulation tool. PyNN officially supports BRIAN, NEST and NEURON SNN simulation tools. It is also supported on SpiNNaker [52] and BrainScaleS-2 [53] neuromorphic hardware systems. There are several more simulation tools which work with PyNN.
\nCypress [54] is a C++ based SNN Simulation tool. This provides a C++ wrapper around PyNN APIs. Hence, extending the multi-platform reach of Cypress using C++ interface. It is also capable of executing networks remotely on neuromorphic compute platforms.
\nThe BrainScaleS-2 [53] is a mixed-signal accelerated neuromorphic system with analog neural core, digital connectivity along with embedded SIMD microprocessor. It is efficient for emulations of neurons, synapses, plasticity models etc. This hardware based system is capable of evaluating models up to ten thousand times faster than real time.
\nThe SpiNNaker [52] is another neuromorphic system custom built with digital multicore ARM processors. The SpiNNaker system (NM-MC-1) consists of custom chips each with eighteen cores sharing a local 128 MB RAM. The overall system scales to more than a million cores.
\nApart from the above tools and platforms the are many custom SNN tools available to model SNNs easily for machine learning purposes. ANNarchy (Artificial Neural Networks architect) [55] is a custom simulator for evaluating SNNs. This is implemented in C++ language, along with acceleration support provided using OpenMP/CUDA. The network definitions are provided using python interface.
\nNeuCube [6] is a development environment for creation of Brain-Like Artificial Intelligence. The computational architecture is suited for modeling SNN applications across several domain areas. This tool supports the latest neural network models for AI purpose. It supports PyNN interface, hence extending its versatility. This tool can run on CPU, GPU and SpiNNaker platforms, also a cloud version of the tool is available.
\nTrueNorth [56] is another neuromorphic platform capable of evaluating SNNs at faster than real time and at very low power. They demonstrate running state of the art neural networks on the hardware platform scaling up to 64 million neurons and 16 billion synapses while the system consumes only 70 W of power out of which only 15 W is consumed by the neuromorphic hardware components. The hardware supports inference only, with learning performed off chip.
\nLoihi [57] is the latest offering in the neuromorphic SNN hardware. This hardware approach gets rid of crossbar architecture, which is prevalent in most previous neuromorphic implementations, lending itself to greater amount of flexibility. Loihi is also capable of on-chip learning which is a huge advantage in terms of online learning of synapses.
\nOther simulators capable of modeling software based models and models for custom neuromorphic hardware are presented in [20, 58, 59, 60]. This is still an ongoing field of research and there are several more accelerator-based simulators available hence the reader is encouraged to explore further. Neuromorphic hardware using more exotic hardware devices like memristors and phase change memories are also an active area of research, they are yet to make it to mainstream consumption hence they are only mentioned here.
\nIn this section few case studies are presented to bolster the concepts discussed in this chapter. The topics covered here include STDP learning dynamics, probabilistic graphical models as SNNs, SNN with BP-STDP based learning and SNNs on Neuromorphic Hardware.
\nA SNN is trained [38] to classify handwritten digits from the MNIST dataset using the STDP based learning rules Exp, Q2PS and 2P presented in Section 4.2. The authors build a three-layer SNN as shown in \nFigure 10\n. The MNIST images are of 28x28 pixel dimensions, hence the input layer contains 784 neurons, one per image pixel. The second/hidden layer contains neurons for learning the features of the input images. The number of neurons in this layer is varied over different trials to evaluate the effectiveness of the learning rule. Finally, the third layer consists of 10 neurons for classifying the input with one neuron per class. The input layer encodes the pixel intensities with varying firing rate in the range of 0 Hz – 300 Hz. Each input neuron is fully connected to the hidden layer neurons similarly each hidden layer neuron is fully connected to the output/classification layer neurons. In this network all synapses are plastic with soft WTA connectivity implemented between input layer and hidden layer neurons to facilitate different neurons to pick up shared features. On the other hand, a hard WTA connectivity exists between hidden layer and the classification layer.
\nMNIST SNN architecture showing connectivity, input, learnt features, labels and t-SNE visualizations, along with accuracy results [
A qualitative analysis of the learning rule is depicted by the t-distributed stochastic neighbor embedding (t-SNE) [61] visualizations in \nFigure 10\n. The t-SNE algorithm maps high dimensional data points lying on different but related low-dimensional manifolds to lower dimensions by capturing local structure present in high dimensional data. The input layer firing rate visualizations show the clustering of digit classes in 2 dimensions based on raw pixel data which has 784 dimensions. Similarly, the second visualization is made using the firing rate based on the learnt features of hidden layer as input to the t-SNE algorithm with 100 dimensions. It can be clearly seen that the STDP rule produces tight clustering of input space which is projected on to the feature space. The classification layer further groups these features to its respective classes. Networks with different number of hidden layer neurons are experimented with and the results are shown in the bottom right side of \nFigure 10\n. The robustness of the learning method is also demonstrated with experiments yielding similar accuracies with additive Gaussian white noise along with the use of NWTA network.
\nAn inference network based on a probabilistic graphical model for sentence construction is created using Bayesian neurons. It consists of lexicons representing words and phrases. Here each lexicon is a WTA sub network.
\nThe network consists of two functional sections: word sub network and phrase sub network. Each symbol neuron in word sub network represents a possible word occurrence and each symbol neuron in phrase sub network represents a possible pair of words co-occurring. The synapses between the symbol neurons represent the log conditional probabilities of words and phrases co-occurring. This network is initialized to have same intrinsic potential across all symbol neurons resulting in same initial firing rate. Based on the synaptic weights the strongly connected neurons resonate and enhance each other while laterally inhibiting other symbol neurons within the lexicon WTA network. These winning neurons proportionally excite other symbol neurons across different lexicons. In this manner the network settles on a steady state firing rate which represents a contextually correct behavior. From each lexicon of the word sub network a symbol neuron is picked with highest firing rate representing a grammatically correct semantically meaningful sentence. The WTA connections in this network perform soft WTA action there by the facilitating the retention of contextual information. \nFigure 11\n (a) shows the network topology. For the experiments, random documents images are picked, and fuzzy character recognition is performed. Due to the fuzzy nature, each character position will result in several possible matches hence, multiple possible matches for each word position is possible as described in [62]. An example of lexicon set is [{we, wo, fe, fo, ne, no, ns, us} {must, musk, oust, onst, ahab, bust, chat} {now, noa, non, new, how, hew, hen, heu} {find, rind, tina} {the, fac, fro, kho} {other, ether}]. The SNN after evaluating the lexicons settles on a grammatically correct sentence as [we must now find the other] as seen in \nFigure 11\n (b).
\n(a) Sentence confabulation network, (b) confabulation results spike plot [
Using the learning rule presented in Section 4.4, the authors of [45] train SNNs to evaluate BP-STDP rule on the XOR problem, the iris dataset and the MNIST dataset. They show that the network can model the linearly inseparable XOR problem using an SNN with 2 input, 20 hidden and 2 output neurons. For the iris dataset they create a SNN with 4 input, 30 hidden and 3 output neurons. With this network they were able to achieve 96% accuracy which is comparable to ANN trained with traditional backpropagation with an accuracy of 96.7%. The SNN for MNIST dataset consists of 784 input neurons, 100 through 1500 hidden neurons and 10 output neurons. With this network they were able to achieve 97.2% classification accuracy.
\nDeep networks achieve higher accuracy in recognition tasks and in some cases outperform humans. Eedn framework is proposed in [63], which enables SNNs to be trained using backpropagation with batch normalization [64] and implement them on TrueNorth neuromorphic hardware. The Eedn trained networks are capable of achieving state-of-the-art accuracy across eight standard datasets of vision and speech. In this implementation the inference on hardware can be run at up to 2600 frames/s which is faster than real time while consuming very low power of at most 275 mW across their experiments. The network uses low precision ternary weights +1, 0 and − 1 for its synapses. A binary activation function with an approximate derivative is modeled to enable backpropagation. A hysteresis parameter is introduced in the weight update rule to avoid rapid oscillations of weights during learning. The input images are transduced by applying 12 different convolutional filter operators with binary outputs to get 12 channel input to the network as shown in \nFigure 12\n.
\nExample image from CIFAR10 (column 1) and the corresponding output of 12 typical transduction filters (columns 2–13) [
Experiments were performed on eight datasets using five different network sizes spanning across several TrueNorth chips. The results of the experiments are summarized in \nFigure 13\n.
\nAccuracy of different sized networks on eight datasets. For comparison, accuracy of state-of-the-art unconstrained approaches are shown as bold horizontal lines [
This chapter discussed several concepts and techniques, all of which are bio inspired. The case studies presented provide a strong basis to grasp the immense potential these algorithms provide in tackling the very complex problems of today, which were unimaginable without the advances in this field. This chapter specifically provided a beginner’s guide to the field of spiking neural networks. It presented a brief overview of neuron biology and notes on popular artificial neuron models. Information representation as spikes and how to transduce real world data to spikes and vice-versa was discussed which is similar to how brain represents information. Several tools for spiking neural network modeling and evaluation were provided for wholistic understanding and for experimental evaluation of one’s network models. A few case study examples are presented to understand the presented concepts and the scope of information presented in this chapter. This is an ongoing research and a very hot topic with substantially new concepts and discoveries being published every week. The motivation being the ability for machines to autonomously and efficiently perform tasks which were previously delegated to humans only along every aspect of our lives. This is a paradigm shift and research will continue to not only develop machine intelligence but also to understand the inner workings of our brains, our thoughts and advance the field of neuroscience.
\nThis chapter represents fundamental knowledge for understanding spiking neural networks. Some of the text and images are adopted from the available research literature. Rest of the work represents authors original contributions along with the co-authors of the following research contributions [20, 38, 39, 43, 60, 62]. I am thankful for the support of Dr. Qinru Qiu from Syracuse University and her research group members specifically Amar Shrestha in contributing during the original research.
\nartificial intelligence
\nartificial neural networks
\nBayesian neuron
\nbackpropagation-STDP
\nexcitor neuron
\nlower limit neuron
\nlong-term depression
\nlong-term potentiation
\nmoving-window
\nnormalized winner take all
\nperi-stimulus-time histogram
\nstep-forward
\nspiking neural network
\nspike timing dependent plasticity
\nt-distributed stochastic neighbor embedding
\nupper limit neuron
\nwinner take all
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\\n\\nAll scientific works are Peer Reviewed prior to publishing. Read more
\\n\\nOA Publishing Fees
\\n\\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\\n\\nDigital Archiving Policy
\\n\\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\\n\\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\\n\\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\\n\\nOpen Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\\n\\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
\\n\\n\\n"}]'},components:[{type:"htmlEditorComponent",content:'
The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\n\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\n\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\n\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\n\nOAI-PMH
\n\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\n\nLicense
\n\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\n\nPeer Review Policies
\n\nAll scientific works are Peer Reviewed prior to publishing. Read more
\n\nOA Publishing Fees
\n\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\n\nDigital Archiving Policy
\n\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\n\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\n\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\n\nOpen Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\n\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. 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After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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Fifty-two articles were reviewed; however, 14 of them were not been included in the study. As a result, 38 articles were examined. Level of education, field of education, and material types of AR used in education and reported educational advantages of AR have been investigated. All articles are categorized according to target groups, which are early childhood education, primary education, secondary education, high school education, graduate education, and others. AR technology has been mostly carried out in primary and graduate education. “Science education” is the most explored field of education. Mobile applications and marker-based materials on paper have been mostly preferred. 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Research continuously innovates to develop efficient and cheap methods to sustain clean water for developing countries. Developing nations are a broad term that includes countries that are less industrialised and have lower per capita income levels than developed countries. This chapter will discuss clean water for drinking water purposes. Pollution concerns of water in developing countries will be categorised in terms of physical, chemical and biological pollutants such as turbidity, organic matter and bacteria. Natural and anthropogenic pollution concerns linking with seasonal factors will be outlined. The multi-barrier approach to drinking water treatment will be discussed. Abstraction points used will be researched. Water treatment systems, medium- to small-scale approaches, will be discussed. The processes involved in removing the contaminants including physical processes such as sedimentation, filtration such as slow-sand filtration, coagulation and flocculation, and disinfectant processes such as chlorination will be reviewed. Other important methods including solar disinfection, hybrid filtration methods and arsenic removal technologies using innovative solid phase materials will be included in this chapter. Rainwater harvesting technologies are reviewed. Safe storage options for treated water are outlined. Challenges of water treatment in rural and urban areas will be outlined.",book:{id:"6682",slug:"the-relevance-of-hygiene-to-health-in-developing-countries",title:"The Relevance of Hygiene to Health in Developing Countries",fullTitle:"The Relevance of Hygiene to Health in Developing Countries"},signatures:"Josephine Treacy",authors:[{id:"238173",title:"Dr.",name:"Josephine",middleName:null,surname:"Treacy",slug:"josephine-treacy",fullName:"Josephine Treacy"}]}],mostDownloadedChaptersLast30Days:[{id:"58890",title:"Philosophy and Paradigm of Scientific Research",slug:"philosophy-and-paradigm-of-scientific-research",totalDownloads:13759,totalCrossrefCites:9,totalDimensionsCites:17,abstract:"Before carrying out the empirical analysis of the role of management culture in corporate social responsibility, identification of the philosophical approach and the paradigm on which the research carried out is based is necessary. Therefore, this chapter deals with the philosophical systems and paradigms of scientific research, the epistemology, evaluating understanding and application of various theories and practices used in the scientific research. The key components of the scientific research paradigm are highlighted. Theories on the basis of which this research was focused on identification of the level of development of the management culture in order to implement corporate social responsibility are identified, and the stages of its implementation are described.",book:{id:"5791",slug:"management-culture-and-corporate-social-responsibility",title:"Management Culture and Corporate Social Responsibility",fullTitle:"Management Culture and Corporate Social Responsibility"},signatures:"Pranas Žukauskas, Jolita Vveinhardt and Regina Andriukaitienė",authors:[{id:"179629",title:"Prof.",name:"Jolita",middleName:null,surname:"Vveinhardt",slug:"jolita-vveinhardt",fullName:"Jolita Vveinhardt"}]},{id:"74550",title:"School Conflicts: Causes and Management Strategies in Classroom Relationships",slug:"school-conflicts-causes-and-management-strategies-in-classroom-relationships",totalDownloads:2204,totalCrossrefCites:1,totalDimensionsCites:10,abstract:"Conflicts cannot cease to exist, as they are intrinsic to human beings, forming an integral part of their moral and emotional growth. Likewise, they exist in all schools. The school is inserted in a space where the conflict manifests itself daily and assumes relevance, being the result of the multiple interpersonal relationships that occur in the school context. Thus, conflict is part of school life, which implies that teachers must have the skills to manage conflict constructively. Recognizing the diversity of school conflicts, this chapter aimed to present its causes, highlighting the main ones in the classroom, in the teacher-student relationship. It is important to conflict face and resolve it with skills to manage it properly and constructively, establishing cooperative relationships, and producing integrative solutions. Harmony and appreciation should coexist in a classroom environment and conflict should not interfere, negatively, in the teaching and learning process. This bibliography review underscore the need for during the teachers’ initial training the conflict management skills development.",book:{id:"7827",slug:null,title:"Interpersonal Relationships",fullTitle:"Interpersonal Relationships"},signatures:"Sabina Valente, Abílio Afonso Lourenço and Zsolt Németh",authors:null},{id:"52475",title:"Teenage Pregnancies: A Worldwide Social and Medical Problem",slug:"teenage-pregnancies-a-worldwide-social-and-medical-problem",totalDownloads:8225,totalCrossrefCites:6,totalDimensionsCites:8,abstract:"Teenage pregnancies and teenage motherhood are a cause for concern worldwide. From a historical point of view, teenage pregnancies are nothing new. For much of human history, it was absolutely common that girls married during their late adolescence and experienced first birth during their second decade of life. This kind of reproductive behavior was socially desired and considered as normal. Nowadays, however, the prevention of teenage pregnancies and teenage motherhood is a priority for public health in nearly all developed and increasingly in developing countries. For a long time, teenage pregnancies were associated with severe medical problems; however, most of data supporting this viewpoint have been collected some decades ago and reflect mainly the situation of per se socially disadvantaged teenage mothers. According to more recent studies, teenage pregnancies are not per se risky ones. A clear risk group are extremely young teenage mothers (younger than 15 years) who are confronted with various medical risks, such as preeclampsia, preterm labor, and small for gestational age newborns but also marked social disadvantage, such as poverty, unemployment, low educational level, and single parenting. In the present study, the prevalence and outcome of teenage pregnancies in Austria are focused on.",book:{id:"5392",slug:"an-analysis-of-contemporary-social-welfare-issues",title:"An Analysis of Contemporary Social Welfare Issues",fullTitle:"An Analysis of Contemporary Social Welfare Issues"},signatures:"Sylvia Kirchengast",authors:[{id:"188289",title:"Prof.",name:"Sylvia",middleName:null,surname:"Kirchengast",slug:"sylvia-kirchengast",fullName:"Sylvia Kirchengast"}]},{id:"58060",title:"Pedagogy of the Twenty-First Century: Innovative Teaching Methods",slug:"pedagogy-of-the-twenty-first-century-innovative-teaching-methods",totalDownloads:8743,totalCrossrefCites:15,totalDimensionsCites:21,abstract:"In the twenty-first century, significant changes are occurring related to new scientific discoveries, informatization, globalization, the development of astronautics, robotics, and artificial intelligence. This century is called the age of digital technologies and knowledge. How is the school changing in the new century? How does learning theory change? Currently, you can hear a lot of criticism that the classroom has not changed significantly compared to the last century or even like two centuries ago. Do the teachers succeed in modern changes? The purpose of the chapter is to summarize the current changes in didactics for the use of innovative teaching methods and study the understanding of changes by teachers. In this chapter, we consider four areas: the expansion of the subject of pedagogy, environmental approach to teaching, the digital generation and the changes taking place, and innovation in teaching. The theory of education, figuratively speaking, has two levels. At the macro-level, in the “education-society” relationship, decentralization and diversification, internationalization of education, and the introduction of digital technologies occur. At the micro-level in the “teacher-learner” relationship, there is an active mix of traditional and innovative methods, combination of an activity approach with an energy-informational environment approach, cognition with constructivism and connectivism.",book:{id:"5980",slug:"new-pedagogical-challenges-in-the-21st-century-contributions-of-research-in-education",title:"New Pedagogical Challenges in the 21st Century",fullTitle:"New Pedagogical Challenges in the 21st Century - Contributions of Research in Education"},signatures:"Aigerim Mynbayeva, Zukhra Sadvakassova and Bakhytkul\nAkshalova",authors:[{id:"201997",title:"Dr.",name:"Aigerim",middleName:null,surname:"Mynbayeva",slug:"aigerim-mynbayeva",fullName:"Aigerim Mynbayeva"},{id:"209208",title:"Dr.",name:"Zukhra",middleName:null,surname:"Sadvakassova",slug:"zukhra-sadvakassova",fullName:"Zukhra Sadvakassova"},{id:"209210",title:"Dr.",name:"Bakhytkul",middleName:null,surname:"Akshalova",slug:"bakhytkul-akshalova",fullName:"Bakhytkul Akshalova"}]},{id:"58894",title:"Research Ethics",slug:"research-ethics",totalDownloads:3341,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Research ethics is closely related to the ethical principles of social responsibility. This research covers a wide context of working with people, so the researchers raised a task not only to gain confidence in the respondents’ eyes, to receive reliable data, but also to ensure the transparency of the science. This chapter discusses the theoretical and practical topics of research, after evaluation of which ethical principles of organization and conducting the research are presented. There is a detailed description of how and what ethical principles were followed on the different stages of the research.",book:{id:"5791",slug:"management-culture-and-corporate-social-responsibility",title:"Management Culture and Corporate Social Responsibility",fullTitle:"Management Culture and Corporate Social Responsibility"},signatures:"Pranas Žukauskas, Jolita Vveinhardt and Regina Andriukaitienė",authors:[{id:"179629",title:"Prof.",name:"Jolita",middleName:null,surname:"Vveinhardt",slug:"jolita-vveinhardt",fullName:"Jolita Vveinhardt"}]}],onlineFirstChaptersFilter:{topicId:"23",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82382",title:"A Cultural Approach in the Synchronous Class in English Teaching and Learning",slug:"a-cultural-approach-in-the-synchronous-class-in-english-teaching-and-learning",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.105553",abstract:"If culture is defined as a way of training to obtain knowledge through educational channels, the concept is associated with educability. Therefore, teaching cognitive, attitudinal, and procedural knowledge directly indicates teaching and learning culture to acquire norms and patterns of sociocultural behavior. The purpose of this study was: to debate about the way interaction among students and teachers in synchronous classes based on life’s materials, topics, and methods, and critical or reflective thinking can be adapted by the teacher to the students’ closest environment to communicate in English as an international language. If a language is taught, spoken, and learned in the country, culture surrounding the context is taught. If this language is not spoken in the place, the knowledge system also transmits norms and values, different from those of the language. So, the students get, culturally and socially, modes of action, principles, and knowledge through international language learning. Thus, teaching and learning English as an international language means the way possible interaction has opportunities for every student’s growth and the way their personality formation gets integral results. English taught and learned as an international language denotes reaching the students’ world and needs to communicate in English as a meaningful international language.",book:{id:"10662",title:"Pedagogy - Challenges, Recent Advances, New Perspectives, and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10662.jpg"},signatures:"Ned Vito Quevedo Arnaiz, Nemis García Arias and Fredy Pablo Cañizares Galarza"},{id:"82470",title:"The Effect of COVID-19 on the Quality of Life of Care Workers: Challenges for Social Services Leaders",slug:"the-effect-of-covid-19-on-the-quality-of-life-of-care-workers-challenges-for-social-services-leaders",totalDownloads:4,totalDimensionsCites:0,doi:"10.5772/intechopen.105603",abstract:"Stressful situations are likely to impact health and social care workers’ quality of life negatively. Indeed, mental, physical, and emotional health problems have been reported in relation to the effects of the COVID-19 pandemic on the quality of life of health care workers. Instead of health care workers’ reality, and despite the care sector’s relevance, studies of the effects of COVID-19 on the quality of life of care workers have not been sufficiently explored. Recognizing the effect of COVID on the quality of life of care workers will collaborate with leaders of organizations, social work practitioners, and academics in the design of policies that promote better working conditions. Therefore, during 2021, a study was carried out in Chile where 150 social services and care workers were surveyed in Chile using a version of COV19-QoL in Spanish. The impact of COVID on quality of life is described, and the challenges that this reality implies to social service leaders are presented.",book:{id:"11095",title:"Social Work - Perspectives on Leadership and Organisation",coverURL:"https://cdn.intechopen.com/books/images_new/11095.jpg"},signatures:"Magdalena Calderón-Orellana, Alejandra Inostroza and Paula Miranda Sánchez"},{id:"82448",title:"Virus World Vulnerability: A Critical Reading of Gender and Performance in Bo Burnham’s “Inside” (2021)",slug:"virus-world-vulnerability-a-critical-reading-of-gender-and-performance-in-bo-burnham-s-inside-2021",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.105182",abstract:"Through an engagement with the seminal work of Raewyn Connell on masculinities and hegemonic masculinity, this chapter argues for the hegemonic norm as producing behaviour among men that can be traced in multiple male subjectivities. The argument is that men respond to the prevailing masculine norm by enacting self-protective disavowal—a complex psychological process that involves the reordering of reality in the interests of the maintenance of power, and one that is seen in cases of both legitimate and imagined threats to the self and the body. Self-protective disavowal is at the core of the Same Shit phenomenon—the idea that while the experience of masculinity varies across culture and position in the gender order, self-protective disavowal is a constant that leads to predicable patterns among men. The discussion then explores deliberate vulnerability as a kind of anti-protective disavowal in Bo Burnham’s INSIDE, a complex, undefinable ‘special’ released on Netflix in 2021. The chapter considers Burnham’s work as a departure from self-protective disavowal and Same Shit masculinity through deliberate vulnerability and critically evaluates the value of this alternative, especially given the nihilism that reigns over the work and calls into question the validity of uncritically romanticization of alternatives.",book:{id:"10540",title:"Masculinity Studies - An Interdisciplinary Approach",coverURL:"https://cdn.intechopen.com/books/images_new/10540.jpg"},signatures:"Chris McWade"},{id:"82454",title:"Prospects and Pitfalls Experienced by Social Workers Working in a Confounding Environment in a South African Setting",slug:"prospects-and-pitfalls-experienced-by-social-workers-working-in-a-confounding-environment-in-a-south",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.105604",abstract:"While social workers are professionally and aptly placed to facilitate a turn-around environment rife with a conglomeration of challenges such as poverty, ignorance, and diseases, the chapter discusses the developmental prospects and pitfalls that confound their practice in South Africa. Opportunely, social work interventions continue to gain developmental mileage through increased training of social workers, their increased deployment in various versatile domains of social and economic development and increased widening of the scope of social work research, especially current research in fields such as HIV/AIDS and coronavirus. On the other side of the coin, the chapter discusses social work pitfalls attributed to professional curricular gaps as social work continue to follow a western-centric curriculum; the presence of various metaphysical beliefs and myths that weaken or derail social work interventions and a weaker research environment to offer a plausible and timely solution to the prevalent problems. The chapter concludes by calling for a paradigm shift in the social work curriculum as well as its indigenization to productively respond to the South African socio-cultural and geographical milieu.",book:{id:"11095",title:"Social Work - Perspectives on Leadership and Organisation",coverURL:"https://cdn.intechopen.com/books/images_new/11095.jpg"},signatures:"Simon Murote Kang’ethe"},{id:"82394",title:"Learning by Doing Active Social Learning",slug:"learning-by-doing-active-social-learning",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.105523",abstract:"Project-based learning and future-based pedagogy are important and effective tools for teaching and learning in the twenty-first century. They are especially suited to instilling social activism among students, which is extremely valuable in today’s multicultural society. This study examined the impact of such learning among Arab and Jewish students and teachers in Israel. Following a collaborative program on social activism, in which students from different sectors worked together via digital platforms and face-to-face encounters, the impact of the program and its pedagogical tools were examined. The program, called Living in a Multicultural Society, reflects the mosaic of different people and communities, living side by side yet separated by religion, culture, and language. Through this program, students who may not have otherwise met worked together to learn, research, and create. This study was conducted using the mixed-method approach, whereby the qualitative data were gathered via interviews, and the quantitative data were collected through questionnaires. The findings show that this project-based learning program led to significant encounters, understandings, and co-operations between different sectors, and to meaningful end-products relating to social activism. This study enhances the concept that significant pedagogical processes increase students’ motivation, in-depth learning, and outcomes.",book:{id:"11481",title:"Active Learning - Research and Practice",coverURL:"https://cdn.intechopen.com/books/images_new/11481.jpg"},signatures:"Anat Raviv"},{id:"81785",title:"Social Distancing Disbanding Learner Groupings: A Case on Language Development",slug:"social-distancing-disbanding-learner-groupings-a-case-on-language-development",totalDownloads:11,totalDimensionsCites:0,doi:"10.5772/intechopen.104893",abstract:"Information sharing is a fundamental aspect in learning an unfamiliar, yet, an additional language, with specific regards to reading comprehension. Language teachers are faced with a task to monitor development, performance, and effectiveness in learner reading proficiencies. This chapter aims to measure if disbanding learner groupings as per the social distancing protocols brought about by COVID-19 restrictions has any impact on language enhancement. Henceforth, there are limited suggestions by literature in relation to disbanding learner groupings, yet improved reading proficiency is one of the crucial language aspects to be mastered for one to be a successful scholar. Nonetheless, this chapter aims to provide teaching strategies applied by English language teachers to necessitate transmitted learning in accordance with information sharing as learners are dependent on one another for language enhancement, thus leading to academic achievement.",book:{id:"10912",title:"Psychosocial, Educational, and Economic Impacts of COVID-19",coverURL:"https://cdn.intechopen.com/books/images_new/10912.jpg"},signatures:"Bulelwa Makena and Thandiswa Mpiti"}],onlineFirstChaptersTotal:148},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:320,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:16,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"13",title:"Veterinary Medicine and Science",doi:"10.5772/intechopen.73681",issn:"2632-0517",scope:"Paralleling similar advances in the medical field, astounding advances occurred in Veterinary Medicine and Science in recent decades. These advances have helped foster better support for animal health, more humane animal production, and a better understanding of the physiology of endangered species to improve the assisted reproductive technologies or the pathogenesis of certain diseases, where animals can be used as models for human diseases (like cancer, degenerative diseases or fertility), and even as a guarantee of public health. Bridging Human, Animal, and Environmental health, the holistic and integrative “One Health” concept intimately associates the developments within those fields, projecting its advancements into practice. This book series aims to tackle various animal-related medicine and sciences fields, providing thematic volumes consisting of high-quality significant research directed to researchers and postgraduates. It aims to give us a glimpse into the new accomplishments in the Veterinary Medicine and Science field. By addressing hot topics in veterinary sciences, we aim to gather authoritative texts within each issue of this series, providing in-depth overviews and analysis for graduates, academics, and practitioners and foreseeing a deeper understanding of the subject. Forthcoming texts, written and edited by experienced researchers from both industry and academia, will also discuss scientific challenges faced today in Veterinary Medicine and Science. In brief, we hope that books in this series will provide accessible references for those interested or working in this field and encourage learning in a range of different topics.",coverUrl:"https://cdn.intechopen.com/series/covers/13.jpg",latestPublicationDate:"June 29th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:11,editor:{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"19",title:"Animal Science",coverUrl:"https://cdn.intechopen.com/series_topics/covers/19.jpg",isOpenForSubmission:!0,editor:{id:"259298",title:"Dr.",name:"Edward",middleName:null,surname:"Narayan",slug:"edward-narayan",fullName:"Edward Narayan",profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",biography:"Dr. Edward Narayan graduated with Ph.D. degree in Biology from the University of the South Pacific and pioneered non-invasive reproductive and stress endocrinology tools for amphibians - the novel development and validation of non-invasive enzyme immunoassays for the evaluation of reproductive hormonal cycle and stress hormone responses to environmental stressors. \nDr. Narayan leads the Stress Lab (Comparative Physiology and Endocrinology) at the University of Queensland. A dynamic career research platform which is based on the thematic areas of comparative vertebrate physiology, stress endocrinology, reproductive endocrinology, animal health and welfare, and conservation biology. \nEdward has supervised 40 research students and published over 60 peer reviewed research.",institutionString:null,institution:{name:"University of Queensland",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},{id:"20",title:"Animal Nutrition",coverUrl:"https://cdn.intechopen.com/series_topics/covers/20.jpg",isOpenForSubmission:!0,editor:{id:"175967",title:"Dr.",name:"Manuel",middleName:null,surname:"Gonzalez Ronquillo",slug:"manuel-gonzalez-ronquillo",fullName:"Manuel Gonzalez Ronquillo",profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",biography:"Dr. Manuel González Ronquillo obtained his doctorate degree from the University of Zaragoza, Spain, in 2001. He is a research professor at the Faculty of Veterinary Medicine and Animal Husbandry, Autonomous University of the State of Mexico. He is also a level-2 researcher. He received a Fulbright-Garcia Robles fellowship for a postdoctoral stay at the US Dairy Forage Research Center, Madison, Wisconsin, USA in 2008–2009. He received grants from Alianza del Pacifico for a stay at the University of Magallanes, Chile, in 2014, and from Consejo Nacional de Ciencia y Tecnología (CONACyT) to work in the Food and Agriculture Organization’s Animal Production and Health Division (AGA), Rome, Italy, in 2014–2015. He has collaborated with researchers from different countries and published ninety-eight journal articles. He teaches various degree courses in zootechnics, sheep production, and agricultural sciences and natural resources.\n\nDr. Ronquillo’s research focuses on the evaluation of sustainable animal diets (StAnD), using native resources of the region, decreasing carbon footprint, and applying meta-analysis and mathematical models for a better understanding of animal production.",institutionString:null,institution:{name:"Universidad Autónoma del Estado de México",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"28",title:"Animal Reproductive Biology and Technology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/28.jpg",isOpenForSubmission:!0,editor:{id:"177225",title:"Prof.",name:"Rosa Maria Lino Neto",middleName:null,surname:"Pereira",slug:"rosa-maria-lino-neto-pereira",fullName:"Rosa Maria Lino Neto Pereira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9wkQAC/Profile_Picture_1624519982291",biography:"Rosa Maria Lino Neto Pereira (DVM, MsC, PhD and) is currently a researcher at the Genetic Resources and Biotechnology Unit of the National Institute of Agrarian and Veterinarian Research (INIAV, Portugal). 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He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"243698",title:"Dr.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. 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\r\n\tSustainable development focuses on linking economic development with environmental protection and social development to ensure future prosperity for people and the planet. To tackle global challenges of development and environment, the United Nations General Assembly in 2015 adopted the 17 Sustainable Development Goals. SDGs emphasize that environmental sustainability should be strongly linked to socio-economic development, which should be decoupled from escalating resource use and environmental degradation for the purpose of reducing environmental stress, enhancing human welfare, and improving regional equity. Moreover, sustainable development seeks a balance between human development and decrease in ecological/environmental marginal benefits. Under the increasing stress of climate change, many environmental problems have emerged causing severe impacts at both global and local scales, driving ecosystem service reduction and biodiversity loss. Humanity’s relationship with resource exploitation and environment protection is a major global concern, as new threats to human and environmental security emerge in the Anthropocene. Currently, the world is facing significant challenges in environmental sustainability to protect global environments and to restore degraded ecosystems, while maintaining human development with regional equality. Thus, environmental sustainability with healthy natural ecosystems is critical to maintaining human prosperity in our warming planet.
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Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment"},{id:"5",title:"Parasitic Infectious Diseases",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. 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Dr. Şentürk currently works as an professor of Biochemistry in the Department of Basic Pharmacy Sciences, Faculty of Pharmacy, Ağri Ibrahim Cecen University, Turkey. \nDr. Şentürk published over 120 scientific papers, reviews, and book chapters and presented several conferences to scientists. \nHis research interests span enzyme inhibitor or activator, protein expression, purification and characterization, drug design and synthesis, toxicology, and pharmacology. \nHis research work has focused on neurodegenerative diseases and cancer treatment. Dr. Şentürk serves as the editorial board member of several international journals.",institutionString:"Ağrı İbrahim Çeçen University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Ağrı İbrahim Çeçen University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"July 5th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:320,numberOfPublishedBooks:32,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",fullName:"Abdulsamed Kükürt",profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",institutionString:null,institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}},{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/50095",hash:"",query:{},params:{id:"50095"},fullPath:"/chapters/50095",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()