\r\n\tThis book will provide information about fouling mitigation in general and the ecofriendly methods of fouling mitigation. Chapters from this book will inform the readers about fouling models and predictive maintenance of the equipment prone to fouling. Adaptive means for prolonged continuous operation will also be addressed. This book will guide the readers in selection of fouling mitigation approaches for different applications. A brief discussion on economic impact of fouling in different industries will also be part of this book.
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The web addresses correspond to December 2015.
Useful books on reliability, probability, risk, maintenance, and related subjects are listed in the References in this book. Many others can be found in various libraries. Some books are freely accessible via
The web pages presented below offer information on the reliability-related journals, contents of individual volumes and abstracts, as well as other useful information. For the unsubscribed readers, often it is possible to buy the pertinent article and sometimes even to get free access to the full text via web.
A scientific journal devoted to the development and application of methods for the enhancement of the safety and reliability of complex technological systems. It is published by Elsevier in association with the European Safety and Reliability Association and the Safety Engineering and Risk Analysis Division.
A journal published four times a year by ReliaSoft Corporation brings articles related to the reliability engineering theories and principles along with useful information on ReliaSoft’s upcoming training seminars and product updates.
An Internet journal bringing news from reliability and solutions of various practical problems (see also the title “Weibull” below).
A scientific journal devoted to the problems of quality and reliability. Published by John Wiley & Sons, Ltd.
A scientific journal devoted to the principles and practices of reliability, maintainability, and product liability pertaining to electrical and electronic equipment.
A scientific journal devoted to the reliability of electronic elements.
A scientific journal devoted to the reliability of electronic components. Published by Elsevier.
A scientific journal devoted to the problems of testing and reliability of software. Published by John Wiley & Sons, Ltd.
An electronic journal devoted to maintenance.
A journal for professionals on reliability and maintenance.
The newsletter for warranty management professionals.
The Internet is a very important source. This paragraph presents the links to several servers devoted to reliability and related topics. However, the named sources correspond to the date when this book was published, and changes cannot be excluded (as usual with Internet).
This web contains lot of useful information, including links to the specialized papers on reliability (freely accessible), calendar of events, info on books to buy, or discussion forum.
This corporation offers various software and courses oriented to the automotive industry but not only to this. It also operates the portal
Consultancy firm offering various courses from reliability area and many interesting texts (including some standards of Military Handbook) and software products, some of them for free. It also offers books for sale.
The Center provides expert services, information support and education for people engaged in reliability and also a forum for the exchange of information from reliability, information on literature, software tools, standards, publications, and older issues of the journal published by SRC. It operates a Toolbox with answers to many practical problems.
The reliability engineering web site devoted to theory, data analysis, and modelling. It includes sections on life testing, system reliability and maintainability, reliability growth analysis, FMEA and FMECA, reliability-centered maintenance (RCM), and design of experiments (DOE). It also contains the info on books and free access to the magazine
A firm offering (among other products) courses, consulting services, special books on reliability, and downloadable informative texts and data related to various reliability problems.
Web pages related to maintenance and maintainability.
A source for reliability and maintenance management and professionals for the exchange of experience. It informs on conferences and courses and contains freely accessible articles dealing with solution of many practical problems related to operation and maintenance.
A portal for industrial maintenance, informing about issues on maintenance and reliability, including books. It contains many articles devoted to practical problems. Some links, unfortunately, are no more active, as this service was understood as a competition to Google.
Web portals enabling search for information on any topic, including reliability, probability, mathematics, maintenance, and many others.
Very important for the assessment of reliability and availability of various appliances and systems are the data on reliability of mass-produced components. Some values of failure rate can be found, for example, in the databases
More comprehensive versions of these databases can be purchased, for example via Quanterion Solutions, Inc., or other providers. Some data on the reliability of electric components can be found in the Military Handbook Reliability Prediction of Electronic Equipment (MIL HDBK 217), 1991 issue; see
Note: Some of the data available in the above databases are not “up-to-date” but still contain useful information.
A nonprofit professional organization aimed at the advancement of safety and reliability technology in all areas. It informs on various activities and conferences, publishes ESRA Newsletters, and organizes the annual European Safety and Reliability Conference ESREL.
This Association provides a forum for the exchange of information, data, and current research in Safety and Reliability.
The main purpose of IAPSAM is to sponsor and oversee the organization of the International Conferences on Probabilistic Safety Assessment and Management (PSAM).
A division of the important professional organization IEEE publishes Transactions on Reliability and other journals; organizes international symposia on reliability, availability, quality, and system safety; and informs on various events, standards, and literature.
A section for reliability within the American Society for Quality. It informs on various activities, conferences, literature, journals, newsletters, and courses.
A division of the American Society for Mechanical Engineers (ASME), which stimulates an interest in risk analysis and safety information applied to mechanical engineering.
A division of SAE providing an industry/government forum to review RMS technology and its interfaces with logistics support, engineering design and development, maintainability, reliability, and diagnostics, especially for automotive and aerospace industries.
International professional organisation. Among other activities, it publishes a quarterly journal
A U.S./international nonprofit professional society aiming at the advancement of reliability and physical asset management industry. It is valuable for practitioners looking to expand their knowledge and skills in maintenance and reliability and build business connections with other professionals.
A professional society. The web site contains info on activities, articles, and references.
In addition to those mentioned above, national organizations for reliability and quality exist in various countries and can be found via the Internet. An example follows.
CSQ is an association bringing together individuals and organizations engaged in quality management, reliability, risk and security, environmental management, automotive industry, technical standardization, and others. The special sections organize courses and seminars and publish the corresponding materials (mostly in Czech language).
Technology is advancing in the directions in which it eases life. In the transport industry, it helps to get from point A to point B faster. In the education industry, it helps to obtain knowledge in a more effective way. In the health industry, it helps to operate or diagnose easier. Those are very few examples of how technology is simplifying life. The process of technology advancing is defined in a few steps. The first one is the curiosity about how things work. The second is the willingness to learn. The third is understanding and the fourth is experimenting. The creation of 3D computer graphics had a similar process. Firstly, there was a curiosity about how people see and percept the world. Secondly, it was a willingness to learn how the visual information from the outside world is getting into person. From that point, people realized that eyes were the ones to blame. Willingness to learn continued in this area and later on there was an understanding. The understanding of how the eyes work helped to create the first photographic camera. Lastly, there was experimenting in this field which led to the first photographs. As it is the nature of humans, we wanted to achieve more. We wanted to make those photographs to be animated and displayed somewhere. The development of this technology has gained rapid momentum. Soon, people were able to watch a short movie on canvas. With an introduction of the first computer, those two areas soonly merged. Before that, there was a need to represent data calculated on computer. Soon, it was represented on a simple display. As computers advanced and were more complex, there was a need to represent calculated data more effectively. Computer monitors were introduced and computer graphic was born. Before it reached the possibility of 3D displaying, 2D scenes were presented. The most popular one was television. This is the greatest example so-called eye (visual) and computer content. As people realized how effective and entertaining computers can be, they started to wonder if we can simulate our world. Information from the computer area, eyes (visual) information and mathematics combined, and 3D computer graphics was born.
3D graphics opened a new world of experimenting in the area. As we live in a three-dimensional world, it gives us another level of possibilities of how to simulate and improve the virtual world-virtual reality. Representation of virtual reality via 3D technologies gives more authenticity and credibility. Virtual reality (VR) and related technologies are penetrating almost every aspect of our lives [1]. Nowadays, it is one of the most developing technologies that could significantly increase the level of interactivity [2]. This is greatly used in every industry. It has a great impact on health industry as it is possible to create projects like wheelchair simulators for people who are temporarily or permanently immobilized. Those people are provided with a number of courses to gain wheelchair skills but it is often financially unavailable. Virtual reality was proven as an effective tool for disabled people [3].
This chapter is dedicated to the description of 3D computer graphics used for the needs of virtual reality. The wheelchair simulator is used as an example of the implementation environment. Wheelchair simulator was built using web technologies via A-frame framework [4]. It is a simulation of a collaborative environment in VR (developed in authors’ home laboratory LIRKIS at Department of Computers and Informatics, Technical University of Košice) where an immobilized patient should learn using an electric wheelchair. Guest can join the same 3D virtual environment and watch patient deal with the obstacles. Whole simulator contains multiple scenes with different obstacles. The pilot project was also implemented in a unique 3D virtual LIRKIS CAVE environment (Figure 1).
Patient on wheelchair in 3D virtual LIRKIS CAVE environment.
There are many works related to 3D computer graphics in virtual reality. Some of the works focus on different virtualization algorithms, others try a new methodology of improving realistic look while maintaining the smoothness of application. Related work below simply focuses on new methodologies or approaches to 3D computer graphics or comparing them.
Chen in [5] describes the rapid creation of photorealistic virtual reality content with consumer depth cameras. Work focuses on the demonstration of a complete end-to-end pipeline for the capture, processing, and rendering of view-dependent 3D models in virtual reality from a single consumer-grade RGB-D camera. The result of this pipeline is a 3D mesh with view-dependent textures suitable for real-time rendering in virtual reality. Progressive feedback point cloud rendering for virtual reality display is the aim of [6]. Work presents a novel approach to a progressive feedback-driven rendering algorithm. This algorithm uses reprojections of past views to accelerate the reconstruction of the current view. The presented method is tested against previous methods, showing improvements in both rendering quality and interactivity. In the [7] is indicated virtual content creation using dynamic omnidirectional texture synthesis. This work proposes optimization that synthesizes a high resolution view-dependent texture map for any virtual camera location. Synthetic textures are generated by uniformly sampling a spherical virtual camera set surrounding the virtual object, thereby enabling efficient real-time rendering for all potential viewing directions.
The paper [8] describes three views of virtual reality: non-immersive virtual reality, and it discusses the advantages and applications of non-immersive VR systems. Immersive and non-immersive VR systems are compared and hybrid possibilities are reviewed.
Kautz et al. [9] present new algorithms and techniques for the acquisition and real-time interaction with complex textured 3D objects and shows how these results can be seamlessly integrated with previous work into a single framework for the acquisition, processing, and interactive display of high-quality 3D models. In addition to pure geometry, such algorithms also have to take into account the texture of an object and its reflectance behavior. The research [10] presents a novel 3D user interface for the immersive design review. This research focuses on the development of a novel immersive user interface, a smart 3D disk with a set of widgets. During the immersive sessions, the user can activate functionalities using cost-effective pointing devices and the conceived 3dUIs projected into the more complex CAD functionalities such as surfaces shape modification.
3D computer graphics are graphics that use a three-dimensional representation of geometric data that are stored in a computer for the purpose of performing calculations and rendering 2D images. Those geometric data are not graphics until they are presented on a screen. Geometric data can be perceived as objects or models. To build up a 3D world in virtual reality, it is needed to include graphic elements such as:
A combination of all mentioned graphic elements can result in scene as shown in Figure 2 left. Another 3D scene can be seen in drone simulation environment represented in Figure 2 right.
Example representation of the wheelchair simulator scene and the drone simulation scene.
Rendering can be perceived as the final process of creating the final 2D image from the prepared scene. These images are played at some speed rate. It is called frames per second (FPS). This variable indicates how many final 2D images are rendered in 1 second on the screen. The higher the value, the smoother is playback image. FPS can be used as final control of how great was handled graphics optimalization with a given graphics processing unit (GPU). It is important to handle draw calls effectively as it results in smoother applications. Rendering can be divided into real-time rendering and non-real-time rendering.
Speed of rendering depends not only on effective optimalization of application but also on hardware specification of device like GPU, CPU, and memory, for example. This is a reason why the same application can be smooth in desktop computers but not in VR standalone headsets. Therefore, there is a need for 3D graphics knowledge and hardware specification knowledge to optimize application if it is built for multiple platforms.
General optimalization in 3D applications consists of multiple steps. But firstly, it is important to realize what is the desired result. To call application optimalized, it is desired to achieve a count of draw calls as small as possible, limit the unnecessary calculations or optimize complexity. This can be achieved through several steps, for example:
Lights in 3D virtual environments are necessary for objects to be visible. The same logic applies in real world. Without light, it is not possible to see your surroundings. There are several types of lights, but most common are
Four out of five scenes with ambient lighting.
One of the scenes is designed to be at night. Scene is called crosswalk-night. As is mentioned above, ambient light is everywhere and it illuminates every object evenly from every side. Figure 4 shows the scene.
Representation of crosswalk-night scene.
It is possible to observe that besides ambient light, fog is implemented as well. Fog allows to shade the objects at a certain distance in a predetermined color. It is implemented on camera of the user and not as a light object. Therefore, fog is not perceived as a lighting setting but as a shading setting. In this case, distance of shading is few meters from the user, and color of shading is black. This way it is possible to simulate first-person view at night, samely as in real life. From Figure 4, it is also possible to see the red traffic light, which signals that patient cannot cross the crosswalk as cars are moving. The red color on a box may seem a lot lighter than surroundings. It is because of emissive intensity of material on a traffic light was set on a higher value to make it seems lit. This way, it is not necessary to add the point light in the environment and it will lighten the computational core. Details are explained in Section 3.3. But it is necessary to keep in mind, if priority is to develop application with high rate of frames per second, it can affect the realistic look of the scene. Especially, for virtual headsets as their computational cores are not so advanced yet. Figure 5 shows the traffic light with an implementation of point light in red color and with shadows settings.
Traffic light with point light in red color and shadow settings.
Thanks to specific light definition, it is possible to observe illuminated and unlit parts of an object. Light has an exact border where the illumination of object ends. Therefore, it is needed to shade the transition between illuminated and unlit parts to make it appear more natural. Shader will make a transition by adjusting the color of the nearest pixels between these two sections. Figure 6 shows the illuminated part, shaded part, and unlit part of the cone illuminated by point light only.
Shader represented on a cone with a point light.
All mentioned light types can be used at a same time and multiple times in a scene. Figure 7 shows implementation of spot light, which is red, point light which is blue, and directional light which is white.
Combination of spot light, point light, and directional light in a scene.
All lights presented in Figure 7 are casting shadows. All objects are casting and receiving shadows as well. This is an example of how light can simulate the real-world behavior of lighting. Even though it looks natural and realistic, it is needed to keep in mind that there is a lot of calculation done in the background. It is possible to observe that blue light is illuminating the shadowed part on a terrain from the red light as well as the not shadowed part. Directional light illuminates area of red light and blue light at once but also creates shadows on a left from the cones. All lights are penetrating areas of other light, therefore, renderer needs to consider priority of which light it will display. It is possible to bake these lights at the same time, but calculation complexity will greatly improve. Vectors from lights are crossing paths, which mean they are affecting each other. Therefore, they need to be recalculated to give a result similar, if not same, to a real world. Simply said, the more lights are used in a scene and the more they are penetrating into areas of other lights, the higher complexity lighting setting will have. If renderer needs to take shadows into account, it needs to calculate position, rotation, and size of an object for every light separately as well. And lastly, renderer needs to compare position of the object which is receiving the shadows to an object which is casting the shadow. When creating a 3D scene, it is advised to consider lighting logistics depending on the strength of the computational core as it can cause computational load which can result in small FPS.
Wheelchair simulators were using few point lights for better authenticity. But after profiling of performance was done, FPS was lower than 60 in virtual headsets. The main goal of simulator was to teach disabled person using the wheelchair and overcame obstacles. To teach that, realistic graphics were on a lower priority than smoothness of application. Due to this fact, all unnecessary lights were removed from the scene and ambient light was implemented. Ambient light is considered as the light with the lowest cost for the computational core. Therefore, shadows were not implemented at all, as ambient light cannot cast them. If shadows cannot be cast, there is no need for a shader. Result is a simple lighting setting but a lot of computational space is saved.
The whole process of object processing and virtualization is called the virtualization sequence. A simplified 3D virtualization sequence scheme is shown in Figure 8. Of course, each of these steps contains a number of other sub-steps naturally. Many sub-sequences of this sequence including 3D objects modeling and editing are already standardly used in practice, and they have steady conventions and standards. The virtualization sequence is important in defining and creating VR-based systems. In principle, it determines all the virtual world objects, their way of use, and of course, the semantics (meaning) of individual objects [11].
A simplified 3D virtualization sequence scheme.
As mentioned in the chapter, 3D computer modeling is the creation or modification of a 3D graphical virtual model using a specific software tool—3D modeling application (e.g. Blender, Autodesk 3D Studio Max, Maya, Sketchup, etc.). The modeling process of preparing/editing graphical data is similar to sculpture creation. 3D objects modeling is not an exception in this case and it is based on a four-step principle: model/object preparation, polygonal modeling, texture preparation, and texture application and filtering. The properties of these steps depend on the model/object type. The created model/object can be used for visualization, simulation, or for 3D printing.
Each model consists of
Points, edges, and faces represented on cone model.
Wheelchair model has assigned base color texture. A number of polygons are in a count necessary to shape the model into a wheelchair look. Although it does not look realistic, it brings a possibility to render such model faster. Therefore, its optimal design solution for VR headsets. All models in wheelchair simulators are designed with low polygons principle. Due to this fact, scenes have united design with fast rendering. As helmets are used commercially, it is generally known that realistic look does not affect the possibility of user being drawn into the environment. The user is drawn into the environment, especially, by united design of models and their texture, interactivity with environment and sound effects. If these elements are designed creatively and are not exaggerated, user can enjoy the virtual world samely as environment with realistic look.
Target devices for wheelchair simulators are virtual headsets, therefore, it is needed to keep objects geometry as simple as possible. The higher is complexity of an object, the more it is compelling for the renderer to process. Every polygon in the object will burden renderer to calculate it and display it on the final screen. Due to this fact, many applications for virtual reality use low polygon technique of modeling. Figure 10 shows geometry of some objects used in the simulator.
Geometry representation of wheelchair, avatar, headset, and car models.
As Figure 10 proves, models are build up the way just to represent its necessary shapes, to figure out meaning of the object. Disadvantage of low polygon objects is that neglected folds result in a non-realistic look. But it still keeps the shape to figure out the context. One of the advantages is, that this type of modeling practice does not require creating lots of details—LOD for every object. LOD is also an unnecessary feature in wheelchair simulators as scenes are not that wide for LOD to be applied. It is possible to decimate some polygons on a wheelchair or the car model, for example, those parts of model that are not so visible by a user. But a number of polygons will not change dramatically if it is desired to keep the look so it is an unnecessary step. Such a step would be worth considering if these objects were placed into environment multiple times. Then the polygon reduced will be the number of reduced polygons times the number of duplicated models.
Wheelchair simulator does not use special texturing features, such as normal mapping or Dot 3 bump mapping. It uses only simple base color textures and image textures. If the quality of the image texture is restricted to smaller size and resolution, rendering will be optimalized to desired preferences. Wheelchair simulator is using resolution and size up to 5 megabytes. But the average sizes of image textures are 300–500 kb. Following Figure 11 represents an example of image texture of car with a size of 387 kb and virtual headset object with assigned based colors. Image texture of a car also shows the mapping of the taxi car object. Mapping is represented with points primitives of an object. Their position defines the position of the texture on the object.
Texture representation on taxi car and VR headset models.
Resolution of a texture is important to be optimalized. If the texture has for example resolution of 4000 × 4000 pixels, but texture coloring and details can fit into resolution 500 × 500 pixels without any pixel compressing, it is highly recommended to change the resolution of the texture. Every time, when an object is in a field of view, piece of texture is rendered in dependence on the face shape and size of an object. Therefore, if the simple cube with 6 walls-6 faces have assigned full-size texture with resolution 4000 × 4000 pixels on each face, and top side, right side, and left side of a cube are in a field of view, the texture will be rendered 3 times with defined resolution.
Camera and screen settings can facilitate render calculation as well. To do so, it is needed to reconsider, for example, if it is more effective to use
Besides saving computational cost, camera has some features to manipulate the graphics and visualization in scenes as well. One of the features was presented in Section 3. And in Figure 3. As it was mentioned before, scene called crosswalk-night is situated at night. In real world, when a person is not in a completely dark environment, he/she can see objects within few meters radius. Visibility, colors, and sharpness of the objects depend on the intensity of light. To simulate such environment, scene contains ambient light of certain intensity—but lower than the ambient light in other scenes. This will secure objects to be visible. To implement logic of seeing things in some radius around a user, a feature called fog need to be applied. Fog has a parameter, which defines what color fog will be. To simulate the night, color needs to be black. Other colors, such as red for example, will be seen in a distance as ambient light is applied all around the scene. Result is shown in Figure 12.
Night implementation in wheelchair simulator.
Figure 12 shows, as user goes further from the crosswalk, other objects will gradually shade as they are not in a radius of fog-free area. It can be observed, that taxi car on an upper part of the figure is visible, but as user went further back, taxi car is not visible anymore.
Others performance improvement techniques such as single pass, multi-pass, occlusion culling are predefined in used framework—A-frame.
When creating a 3D application, it is good to know whether the size of the scene will be wide or small in advance. Wider scenes are used mostly when creating an outdoor environment. In this case, wheelchair simulator is using small scenes. Simulator has a scene where a disabled person needs to go around cones or cross the crosswalk. This activity is placed outside, but scenes were designed with a wall limitation on terrain edges. It is easier to solve graphic limitations with a smaller scene as it does not contain many objects. Polygons’ number is lower which result in faster rendering. Following Figure 13 presents the scenes from the distance together with the top view.
Scenes representation in wheelchair simulator.
One of the wheelchair simulator’s goals was to teach a disabled person to go through elevated terrain. Such obstacles are mostly situated inside buildings in real life. Mostly staircases, which have barrier-free platform placed on them, have the steepest ascent. Therefore, scene with slopes was created. Whole scene consists of one big room with two slopes on the edges of the room and patient can go through them. Scene is categorized as a small scene because its visible width is a few meters. Figure 14 shows scene details as well as its top view with explanation.
Scene with slopes.
People living near roads will encounter crosswalks almost on daily basis. It is an unwritten rule, that crosswalk needs to be crossed as quickly as possible. Disabled person has a speed limitation. Due to this fact happens, some of them do not have confidence doing activities where they or other objects should move fast. Scene with crosswalk was designed for a person to gain confidence in a wheelchair. Scene was designed even in night mode as visibility of objects, such as cars, is limited. It is considered a small scene, even though it is situated outside because terrain is a size of a few meters. Figure 15 shows scene details as well as its top view with explanation.
Scene crosswalk-day and crosswalk-night.
Scenario of crossing is simple. Cars are moving at a certain speed when traffic light is red. The traffic light will, after a few seconds, lights up in orange, signaling that a person can prepare for crossing. Then it lights up green signaling that person can cross the road. Cars will stop in front of the crosswalk. They do not have a collider to make sure, that if the patient is still on the road, and traffic light will light up red, cars will not move him/her out of the map. This can cause discomfort and dizziness.
A person in a wheelchair must learn to control it in a first place. To learn the lever manipulation, how it affects the wheelchair and how to rotate the wheelchair, the scene with cones was created. Obstacle course scene has two routes, where a disabled person can practice its wheelchair skills. That way he/she will gain agility to continue with more difficult obstacles. Cones are static and have colliders so the person in wheelchair does not move them if he/she will bump into them. Same as other scenes, obstacle course is considered as a small scene. Following Figure 16 shows scene details as well as its top view with explanation.
Obstacle course scene.
The elevator scene was designed to teach the person in a wheelchair to go through a narrow hallway or learn how to fit in an elevator. Scene is situated in a building with a staircase. It is impossible to go through the staircase as it has a collider. Therefore, proposed scenario is that person in a wheelchair wants to go upstairs. Figure 17 shows scene details as well as its top view with explanation.
Elevator scene.
3D computer graphics gave the possibility to create a 3D world with scenarios, where immobilized persons can learn to handle the most common obstacles. System is supported for virtual headsets, therefore, immobilized persons can experience more authentic environment. Chapter represents 3D computer graphics used in an environment together with an explanation of why they were implemented that way. Virtual reality is a technology that supports such environments. As VR technology is relatively young and it is still evolving, it was needed to implement such 3D graphics, which will not compromise the smoothness of the simulator. Therefore, simulator is implemented with prioritization of smoothness over a realistic look. Chapter also focuses on such 3D graphics combinations to give the user the best experience.
This work has been supported by the Operational Programme Integrated Infrastructure in a frame of the project: Intelligent systems for UAV real-time operation and data processing, code ITMS2014+: 313011 V422 and co-financed by the European Regional Development Fund and also it has been supported by the KEGA grant No. 048TUKE-4/2022: “Collaborative virtual reality technologies in the educational process”.
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So, air and water can potentially become polluted everywhere. Little is known about changes in pollution rates. The increase in water-related diseases provides a real assessment of the degree of pollution in the environment. This chapter summarizes water quality parameters from an ecological perspective not only for humans but also for other living things. According to its quality, water can be classified into four types. Those four water quality types are discussed through an extensive review of their important common attributes including physical, chemical, and biological parameters. 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Accordingly, 80 medicinal plant species were reviewed; leaves and roots are the main parts of the plants used for preparation of traditional medicines. The local practitioners provided various traditional medications to their patients’ diseases such as stomachaches, asthma, dysentery, malaria, evil eyes, cancer, skin diseases, and headaches. The uses of medicinal plants for human and animal treatments are practiced from time immemorial. Stream/riverbanks, cultivated lands, disturbed sites, bushlands, forested areas and their margins, woodlands, grasslands, and home gardens are major habitats of medicinal plants. Generally, medicinal plants used for traditional medicine play a significant role in the healthcare of the majority of the people in Ethiopia. The major threats to medicinal plants are habitat destruction, urbanization, agricultural expansion, investment, road construction, and deforestation. Because of these, medicinal plants are being declined and lost with their habitats. Community- and research-based conservation mechanisms could be an appropriate approach for mitigating the problems pertinent to the loss of medicinal plants and their habitats and for documenting medicinal plants. Chromatography; electrophoretic, macroscopic, and microscopic techniques; and pharmaceutical practice are mainly used for quality control of herbal medicines.",book:{id:"8502",slug:"plant-science-structure-anatomy-and-physiology-in-plants-cultured-in-vivo-and-in-vitro",title:"Plant Science",fullTitle:"Plant Science - Structure, Anatomy and Physiology in Plants Cultured in Vivo and in Vitro"},signatures:"Admasu Moges and Yohannes Moges",authors:[{id:"249746",title:"Ph.D.",name:"Admasu",middleName:null,surname:"Moges",slug:"admasu-moges",fullName:"Admasu Moges"},{id:"297761",title:"MSc.",name:"Yohannes",middleName:null,surname:"Moges",slug:"yohannes-moges",fullName:"Yohannes Moges"}]},{id:"29764",title:"Underlying Causes of Paresthesia",slug:"underlying-causes-of-paresthesia",totalDownloads:192987,totalCrossrefCites:3,totalDimensionsCites:7,abstract:null,book:{id:"1069",slug:"paresthesia",title:"Paresthesia",fullTitle:"Paresthesia"},signatures:"Mahdi Sharif-Alhoseini, Vafa Rahimi-Movaghar and Alexander R. Vaccaro",authors:[{id:"91165",title:"Prof.",name:"Vafa",middleName:null,surname:"Rahimi-Movaghar",slug:"vafa-rahimi-movaghar",fullName:"Vafa Rahimi-Movaghar"}]}],onlineFirstChaptersFilter:{topicId:"2",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82195",title:"Endoplasmic Reticulum: A Hub in Lipid Homeostasis",slug:"endoplasmic-reticulum-a-hub-in-lipid-homeostasis",totalDownloads:0,totalDimensionsCites:null,doi:"10.5772/intechopen.105450",abstract:"Endoplasmic Reticulum (ER) is the largest and one of the most complex cellular structures, indicating its widespread importance and variety of functions, including synthesis of membrane and secreted proteins, protein folding, calcium storage, and membrane lipid biogenesis. Moreover, the ER is implicated in cholesterol, plasmalogen, phospholipid, and sphingomyelin biosynthesis. Furthermore, the ER is in contact with most cellular organelles, such as mitochondria, peroxisomes, Golgi apparatus, lipid droplets, plasma membrane, etc. Peroxisomes are synthesized from a specific ER section, and they are related to very-long-chain fatty acid metabolism. Similarly, lipid droplets are vital structures in lipid homeostasis that are formed from the ER membrane. Additionally, there is a specific region between the ER-mitochondria interface called Mitochondria-Associated Membranes (MAMs). This small cytosolic gap plays a key role in several crucial mechanisms from autophagosome synthesis to phospholipid transfer. Due to the importance of the ER in a variety of biological processes, alterations in its functionality have relevant implications for multiple diseases. Nowadays, a plethora of pathologies like non-alcoholic steatohepatitis (NASH), cancer, and neurological alterations have been associated with ER malfunctions.",book:{id:"11674",title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg"},signatures:"Raúl Ventura and María Isabel Hernández-Alvarez"},{id:"82438",title:"Mosquito Excito-Repellency: Effects on Behavior and the Development of Insecticide Resistance",slug:"mosquito-excito-repellency-effects-on-behavior-and-the-development-of-insecticide-resistance",totalDownloads:0,totalDimensionsCites:0,doi:"10.5772/intechopen.105755",abstract:"Mosquito’s resistance to avoiding insecticide-treated surfaces (“excito-repellency”) has two effects: irritation from direct contact with a treated area and repellency as an avoidance response to contact with treated surfaces. Nowadays, this behavior appears to reduce the success of mosquito control programs, particularly those based on insecticide-driven strategies. Different systems have been designed to assess the excito-repellency, evaluating numerous insecticides’ irritants, deterrents, and toxic properties at different concentrations. The information provides valuable insights regarding the patterns of mosquito behavior based on their physiological conditions, such as the age of the mosquitoes and the duration of the tests. However, the physiological processes resulting from chemical stimulus contact “chemoreception”) are still poorly explored and understood. This review provides an overview of insecticide effects on mosquito behavior and describes the mechanisms involved in chemical stimuli uptake, translation, and recognition.",book:{id:"11379",title:"Mosquito Research - Recent Advances in Pathogen Interactions, Immunity, and Vector Control Strategies",coverURL:"https://cdn.intechopen.com/books/images_new/11379.jpg"},signatures:"Yamili J. Contreras-Perera, Abdiel Martin-Park, Henry Puerta-Guardo, Azael Che-Mendoza, Silvia Pérez-Carrillo, Irám P. Rodrígez-Sánchez, Pablo Manrique-Saide and Adriana E. Flores"},{id:"82307",title:"The Impact of Heavy Metals on the Chicken Gut Microbiota and their Health and Diseases",slug:"the-impact-of-heavy-metals-on-the-chicken-gut-microbiota-and-their-health-and-diseases",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.105581",abstract:"It is important to consider the health and well-being of birds in various production methods. The microbial makeup and function of a bird’s gastrointestinal (GIT) system may vary based on the bird’s food, breed, age, and other environmental conditions. Gut flora play a critical role in maintaining intestinal homeostasis. Environmental exposure to contaminants such as heavy metals (HMs) has been linked to a wide range of disorders, including the development of dysbiosis in the gut, according to many studies. Changes in the gut microbiota caused by HMs are a major factor in the onset and progression of these illnesses. The microbiota in the gut is thought to be the first line of defense against HMs. Thus, HMs exposure modifies the gut microbiota composition and metabolic profile, affecting HMs uptake and metabolism by altering pH, oxidative balance, and concentrations of detoxifying enzymes or proteins involved in HM metabolism. This chapter will focus on the exposure of chicken to HMs from their feed or water and how these HMs affect the immune system resulting in various diseases.",book:{id:"11345",title:"Broiler Industry",coverURL:"https://cdn.intechopen.com/books/images_new/11345.jpg"},signatures:"Selina Acheampong"},{id:"82436",title:"Heavy Metal Residues in Milk and Milk Products and Their Detection Method",slug:"heavy-metal-residues-in-milk-and-milk-products-and-their-detection-method",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.105004",abstract:"Milk and milk products are an essential part of the human daily diet, and their consumption is steadily increasing. Milk is regarded as a complete food because it contains all of the macronutrients including protein, carbohydrates, fat and vitamins. Milk also has a high concentration of mineral elements (metals) such as sodium, potassium, iron, calcium, magnesium, selenium, copper and zinc. They are critical for proper body growth and maintenance but excess in these metals, particularly, heavy metals cause disturbances and pathological conditions. People nowadays are concerned about food safety issues involving microbial, chemical and physical hazards. Heavy metal residues such as cadmium (Cd), lead (Pb), arsenic (As) and mercury (Hg) pose a chemical hazard. These are the main contaminants. Heavy metals are any metallic chemical elements with a relatively high density (5 g/cc) whose levels must be monitored. Atomic absorption spectroscopy can be used to estimate the heavy metal contamination in milk and milk products.",book:{id:"11741",title:"Trends and Innovations in Food Science",coverURL:"https://cdn.intechopen.com/books/images_new/11741.jpg"},signatures:"Ankur Aggarwal, Tarun Verma and Sumangal Ghosh"},{id:"82362",title:"Studies on the Short-Term Effects of the Cease of Pesticides Use on Vineyard Microbiome",slug:"studies-on-the-short-term-effects-of-the-cease-of-pesticides-use-on-vineyard-microbiome",totalDownloads:0,totalDimensionsCites:0,doi:"10.5772/intechopen.105706",abstract:"In this chapter, an overview of the impact of phytosanitary treatments on the vineyard microbiome is provided, together with the results of the research we conducted. The studied plant material consisted of grapevine from the cultivars Sauvignon blanc and Cabernet Sauvignon, cultivated within the plantation of the Research Station for Viticulture and Enology from Murfatlar, Romania. For each cultivar, a treated plot and an untreated plot were established. For each of those, the phyllosphere microbiota was quantified using the epifluorescence microscopy method, followed by automated image analysis using CellC software. At the same time, the soil fungal diversity was evaluated in three stages during the year 2021, using microscopic morphological criteria. The results give useful information regarding the phytosanitary state of the studied plant, as well as the short-term effects produced by the ceasing of pesticide application on the grapevine microbiota.",book:{id:"11663",title:"Vegetation Dynamics, Changing Ecosystems and Human Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11663.jpg"},signatures:"Simona Ghiță, Mihaela Hnatiuc, Aurora Ranca, Victoria Artem and Mădălina-Andreea Ciocan"},{id:"82423",title:"Removal of Divalent Nickel from Aqueous Solution Using Blue Green Marine Algae: Adsorption Modelling and Applicability of Various Isotherm Models",slug:"removal-of-divalent-nickel-from-aqueous-solution-using-blue-green-marine-algae-adsorption-modelling-",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.103940",abstract:"The adsorption of Ni(II) onto blue green marine algae (BGMA) in batch conditions is being investigated. The highest adsorption capacity of BGMA was found to be 42.056 mg/g under ideal testing conditions, where the initial Ni(II) metal ion concentration was adjusted from 25 ppm to 250 ppm. The optimal pH, biomass loading, and agitation rate for maximum Cu(II) ion removal have been determined to be 6, 2 g and 120 rpm, respectively. For the equilibrium condition, 24 hours of contact time is allowed. At room temperature, all of the experiments are conducted. The isotherm has a L shape, based on the equilibrium experimental data. It indicates that there is no considerable competition for active sites between the solvent and Ni(II). There is no strong competition between the solvent and Ni(II) for the active sites of BGMA, indicating that there is no strong competition between the two. It also suggests that the BGMA’s Ni sorption ability is restricted (II). The experimental data is validated using multiple isotherm models, and the mechanism of adsorption is then discovered, as well as the process design parameters. The Fritz-Schlunder-V isotherm model is particularly relevant in defining the mechanism of Ni(II) adsorption under the conditions used in this study, according to modelling studies. This model’s qmax of 41.89 mg/g shows that it matches experimental data more closely.",book:{id:"11366",title:"Microalgae",coverURL:"https://cdn.intechopen.com/books/images_new/11366.jpg"},signatures:"Ramsenthil Ramadoss, Durai Gunasekaran and Dhanasekaran Subramanian"}],onlineFirstChaptersTotal:544},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"333824",title:"Dr.",name:"Ahmad Farouk",middleName:null,surname:"Musa",slug:"ahmad-farouk-musa",fullName:"Ahmad Farouk Musa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333824/images/22684_n.jpg",biography:"Dato’ Dr Ahmad Farouk Musa\nMD, MMED (Surgery) (Mal), Fellowship in Cardiothoracic Surgery (Monash Health, Aust), Graduate Certificate in Higher Education (Aust), Academy of Medicine (Mal)\n\n\n\nDato’ Dr Ahmad Farouk Musa obtained his Doctor of Medicine from USM in 1992. He then obtained his Master of Medicine in Surgery from the same university in the year 2000 before subspecialising in Cardiothoracic Surgery at Institut Jantung Negara (IJN), Kuala Lumpur from 2002 until 2005. He then completed his Fellowship in Cardiothoracic Surgery at Monash Health, Melbourne, Australia in 2008. He has served in the Malaysian army as a Medical Officer with the rank of Captain upon completing his Internship before joining USM as a trainee lecturer. He is now serving as an academic and researcher at Monash University Malaysia. He is a life-member of the Malaysian Association of Thoracic & Cardiovascular Surgery (MATCVS) and a committee member of the MATCVS Database. He is also a life-member of the College of Surgeons, Academy of Medicine of Malaysia; a life-member of Malaysian Medical Association (MMA), and a life-member of Islamic Medical Association of Malaysia (IMAM). Recently he was appointed as an Interim Chairperson of Examination & Assessment Subcommittee of the UiTM-IJN Cardiothoracic Surgery Postgraduate Program. As an academic, he has published numerous research papers and book chapters. He has also been appointed to review many scientific manuscripts by established journals such as the British Medical Journal (BMJ). He has presented his research works at numerous local and international conferences such as the European Association for Cardiothoracic Surgery (EACTS) and the European Society of Cardiovascular Surgery (ESCVS), to name a few. He has also won many awards for his research presentations at meetings and conferences like the prestigious International Invention, Innovation & Technology Exhibition (ITEX); Design, Research and Innovation Exhibition, the National Conference on Medical Sciences and the Annual Scientific Meetings of the Malaysian Association for Thoracic and Cardiovascular Surgery. He was awarded the Darjah Setia Pangkuan Negeri (DSPN) by the Governor of Penang in July, 2015.",institutionString:null,institution:{name:"Monash University Malaysia",country:{name:"Malaysia"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}}]}},subseries:{item:{id:"7",type:"subseries",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. 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He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/50080",hash:"",query:{},params:{id:"50080"},fullPath:"/chapters/50080",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()