Computational results of sediment yield for the location “Momina Koula”
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"1501",leadTitle:null,fullTitle:"Smart Nanoparticles Technology",title:"Smart Nanoparticles Technology",subtitle:null,reviewType:"peer-reviewed",abstract:"In the last few years, Nanoparticles and their applications dramatically diverted science in the direction of brand new philosophy. The properties of many conventional materials changed when formed from nanoparticles. Nanoparticles have a greater surface area per weight than larger particles which causes them to be more reactive and effective than other molecules. In this book, we (InTech publisher, editor and authors) have invested a lot of effort to include 25 most advanced technology chapters. The book is organised into three well-heeled parts. \nWe would like to invite all Nanotechnology scientists to read and share the knowledge and contents of this book.",isbn:null,printIsbn:"978-953-51-0500-8",pdfIsbn:"978-953-51-5606-2",doi:"10.5772/1969",price:159,priceEur:175,priceUsd:205,slug:"smart-nanoparticles-technology",numberOfPages:590,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"9360fdc75621662ac2971d7472f1f164",bookSignature:"Abbass Hashim",publishedDate:"April 18th 2012",coverURL:"https://cdn.intechopen.com/books/images_new/1501.jpg",numberOfDownloads:96254,numberOfWosCitations:118,numberOfCrossrefCitations:59,numberOfCrossrefCitationsByBook:6,numberOfDimensionsCitations:151,numberOfDimensionsCitationsByBook:9,hasAltmetrics:1,numberOfTotalCitations:328,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 13th 2011",dateEndSecondStepPublish:"May 11th 2011",dateEndThirdStepPublish:"September 15th 2011",dateEndFourthStepPublish:"October 15th 2011",dateEndFifthStepPublish:"February 14th 2012",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"6700",title:"Dr.",name:"Abbass A.",middleName:null,surname:"Hashim",slug:"abbass-a.-hashim",fullName:"Abbass A. 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Especially in deltaic regions, the construction of dams in the river basin acts as an artificial barrier to the sediment supply to the river mouths and therefore the rates of shoreline retreat and sea level rise may exceed the corresponding rates of vertical shoreline accretion, resulting in the increase and in many cases the predomination of deltaic and coastal erosion. Over the last decades, many investigations have been directly or indirectly focused on the assessment of reservoir sedimentation and its effect on sediment yield reduction and coastal erosion, in the wider coastal regions of various rivers worldwide, using different investigation methodologies and techniques (e.g., [1]-[8]).
Nestos constitutes an important transboundary river, characterized by its great biodiversity. It flows through two European countries, Bulgaria and Greece, discharging into the Aegean Sea. It originates from Mount Rila (2716 m) in South Bulgaria, where Nestos River is known as Mesta. Its total length reaches 234 km and the river basin covers an area of 5749 km2, 130 km (<56%) and 2280 km2 (<40%) of which lies in Greek territory [9].
In the Greek part of the river, two hydroelectric dams, the Thisavros Dam and the Platanovrysi Dam, have already been constructed and started operating in 1997 and 1999, respectively. This implies a reduction of sediment yield at the outlet of the Nestos River basin and a corresponding disturbance of the sediment balance in the basin in general, which can result in coastal erosion. However, the reduction of the sediment yield at the outlet of the considered river due to the construction of these two reservoirs as well as the increase in the coastal erosion of the deltaic and the adjacent coastal regions have never been evaluated and correlated previously.
According to the authors’ best knowledge, the work that is presented in the first part of this chapter constitutes one of the first assessments of reservoir sedimentation effect on the coastal erosion for the case of the Nestos River delta and the adjacent shorelines, utilizing mathematical modeling, remote sensing techniques, and field surveying [10]. The main objectives are to evaluate the overall reduction of the sediment yield at the outlet of the river due to the construction of the two dams and to examine the resulting erosion/accretion response of the deltaic as well as the adjacent shorelines. For this purpose, the sediment yield at the outlet of the Nestos River basin before and after the construction of the two dams is calculated, through the application of a mathematical simulation model (RUNERSET – RUNoff ERosion SEdiment Transport). The model is initially tested against appropriate field measurements that are available in the literature. Moreover, a shoreline change monitoring methodology for the coastal region of the Nestos River delta and the adjacent shorelines is proposed, tested, and applied for the digital and detailed extraction of the shoreline position with respect to time, aiming to determine the erosion/accretion shoreline balance for two time periods that correspond to the periods before and after the construction of the dams. Finally, the mathematically calculated reduction of the sediment yield at the outlet of the river is correlated with the results from the application of the shoreline change monitoring methodology and some valuable conclusions and recommendations are drawn. The considered mathematical simulation model (RUNERSET) calculates the mean annual value of sediment yield, due to rainfall and runoff. The proposed model consists of three submodels: a rainfall-runoff submodel, a soil erosion submodel and a sediment transport submodel for streams. The coastal erosion/accretion monitoring data that were used in order to determine the shoreline evolution consist of remote sensing data from high-resolution satellite images (year 2002, considered period of construction/operation of the dams) and aerial photographs (year 1945, period before the construction/operation of the dams/reservoirs) as well as from high-resolution DGPS (Differential Global Positioning System) field measurements (year 2007, period after the construction/operation of the dams/reservoirs). It is calculated that the construction and operation of the considered dams have caused a dramatic decrease (about 83%) in the sediments supplied directly to the basin outlet and indirectly to the neighboring coast, and that this fact has almost inversed the erosion/accretion balance in the deltaic as well as the adjacent shorelines. Before the construction of the reservoirs, in the entire pilot study region, accretion predominated erosion by 25.36%, while just within 5 years of the construction/operation of the reservoirs, erosion predominates accretion by 21.26% [10]. Moreover, in the same part of this chapter, aiming to quantitatively investigate the dynamic evolution of erosion in the considered coastal region, a more recent shoreline (2013) was also extracted. For this purpose, additional DGPS field measurements were performed, following the same methodology and time period (spring) with the corresponding field measurements of the year 2007. Recording this more recent state of the coastline (2013) and comparing with the previous shorelines up to the perceived period of the construction and operation of the dams (2002) showed that erosion, in relation to the deposition/accretion that has been observed in the period 2002-2007, shows an increasing trend.
It has been estimated that every year almost 2% of the effective volume of reservoirs worldwide is lost due to sedimentation. This is an unavoidable fact, which however can be reduced, quantified, and incorporated into the design and operation of a reservoir [11]. The sediment management methods in reservoirs can be classified into three main categories: a) methods that minimize the inflow of sediment into the reservoirs, b) methods that minimize the accumulation of sediment in the upstream part of the reservoir and c) methods that maximize the overall sediment discharge that passes downstream of the reservoirs. The application of this last class of methods could serve as a possible treatment for the reduction of shoreline erosion, which has been mainly caused by the construction of the above-mentioned dams in the case of Nestos River. Two of the most widely applied methods of sediment removal from reservoirs are the processes of mechanical removal or dredging [11] and flushing [12]. In the work that is presented in the second part of this chapter, the dredging as well as the flushing of sediment from the reservoir of Platanovrysi, and its disposal in the subbasin downstream of the Platanovrysi Dam up to the Nestos River delta, are investigated as potential treatment methods of reducing coastal erosion ([13], [14]). For this purpose, the considered mathematical model (RUNERSET) was accordingly modified in order to incorporate these effects, and various scenarios of sediment management in the Platanovrysi Reservoir were simulated, while an assessment of the most effective and consistent month of the year for sediment flushing or dredging, as well as of the maximum transport quantity of the removed material was conducted. Finally, a comparison of the two methods takes place, concerning the maximum sediment quantities that reach the basin outlet, at the optimal for each method month of the year.
The overall findings and conclusions, arising from the work presented and discussed in this chapter, contribute to the need to thoroughly understand the direct effect of dam construction on coastal erosion. More specifically, the presented work constitutes one of the first attempts to quantify the disruption of the sediment balance in the delta of Nestos River due to the construction and operation of the Thisavros and Platanovrysi Reservoirs, considering simultaneously the impact of this disturbance on the erosion/accretion balance both at the river delta and the adjacent shorelines. Moreover, for the first time, an effort is made for the evaluation of the optimum periods and sediment management methods, aiming to increase the annual sediment that reaches the outlet of the Nestos River basin, and consequently to reduce erosion in the delta of the river and the adjacent shorelines. Finally, it is evident that the overall research methodology applied may constitute a quite useful tool for the further investigation of the effect of dam construction on the coastal erosion for other pilot application areas, throughout the world.
As mentioned previously in the introduction section of this chapter, the considered mathematical simulation model (RUNERSET) calculates the mean annual value of sediment yield, due to rainfall and runoff, and it consists of three submodels: a rainfall-runoff submodel, a soil erosion submodel, and a sediment transport submodel for streams.
By means of the rainfall-runoff submodel, the runoff depth for a certain rainfall depth is computed. It is a simplified water balance model [15], in which the variation of soil moisture due to rainfall, evapotranspiration, deep percolation, and runoff is considered. The basic balancing equation is:
where
The direct runoff depth
where
In the present study, two different methods were used for the estimation of the potential evapotranspiration
The following meteorological data are required for the application of the radiation method: mean daily temperature (oC), sunlight hours per day (hr/day), mean daily relative humidity (%), and mean daily wind velocity (m/s). These data were available in the Greek part of Nestos River basin. For the application of the Thornthwaite method, only mean daily temperature data (oC) are required, which were available in the Bulgarian part of the Nestos River basin.
According to the equations given above, apart from the meteorological data, the input data for the rainfall-runoff submodel are: monthly rainfall depth, altitude, latitude, soil cover – land use, and hydrologic soil group.
The soil erosion submodel is based on the assumption that the impact of droplets on the soil surface and the surface runoff are proportional to the momentum flux contained in the droplets and the runoff, respectively [19].
The momentum flux exerted by the falling droplets,
where
The original relationship of Schmidt for the momentum flux exerted by the droplets is valid for bare soils. Therefore, an additional factor is necessary to express the decrease of the momentum flux because of the vegetation. It is believed that the dimensionless crop and management factor
The momentum flux exerted by the runoff,
where
The available sediment discharge per unit width,
where
and
The critical momentum flux
where
The critical runoff rate
Equation (6) suggests the concept of critical situation characterizing the initiation of sediment motion on the soil surface.
The sediment supply
where
The additional input data for the soil erosion submodel, with reference to the rainfall-runoff submodel, are: mean slope angle of soil surface, subbasin area, soil cover factor, length of the main stream of the subbasins, roughness coefficient of soil surface, critical erosion velocity, water, and sediment density.
The sediment yield at the outlet of the main stream of the subbasin considered can be computed by the concept of sediment transport capacity by the stream flow. The following relationships are used to compute sediment transport capacity by the stream flow [20]:
where
Equation (9) was determined from the concept of unit stream power (rate of potential energy expenditure per unit weight of water,
The sediment yield
It is implied from the above relationships that only the main stream of each subbasin is considered, because numerous unavailable data for the geometry and hydraulics of the entire stream system would otherwise be required. Therefore, the additional input data for the stream sediment transport submodel, with reference to the foregoing submodels, concern the main stream of the subbasins: base flow, bottom slope, bottom width, bed roughness, diameter of suspended particles, grain diameter of bed material, and kinematic viscosity of water.
Finally, a sediment routing plan is necessary in order to specify the sediment motion from subbasin to subbasin.
For more precise calculations, the Nestos River basin was divided into 60 subbasins. In more detail, the basin of the Thisavros Reservoir (Bulgarian and Greek parts) was divided into 31 subbasins, the basin of the Platanovrysi Reservoir (Greece) into nine subbasins and the basin downstream of the Platanovrysi Reservoir into 20 subbasins. The outlet of the last basin is known as Toxotes outlet.
Subbasins/main streams map and soil cover map of the Nestos River basin
Available meteorological data (monthly rainfall data and mean monthly temperature data) from 22 meteorological stations in Greece and Bulgaria were used as input data for the simulation model. Various digital thematic maps were constructed from georeferenced background maps, for the accurate computation of the required input parameters. Indicatively, the subbasins and main streams map as well as the soil cover map are depicted in Figure 1.
However, other kind of thematic maps were also constructed and used such as a Thiessen polygons map and a geological map. The calculations were performed on a monthly time basis for each subbasin.
In order to validate the mathematical model predictions, sediment measurements (suspended load) for 53 years (1937-1989) that were available for the location “Momina Koula” [21] in the Bulgarian part of Nestos River (Figure 1), were utilized. According to the measurements, the mean annual suspended sediment yield for the considered time period is 202 t/km2 [21]. Bed load measurements were not available and therefore, the following assumption [10] was made: the ratio of bed load to suspended load at the outlet of a basin on an annual basis amounts approximately to 0.25. According to this assumption, the measured mean annual sediment yield at “Momina Koula” is 252.5 t/km2.
The mathematical model described in the previous section was applied to the basin corresponding to this location for the same time period [10]. The basin area is 1511 km2, which is about 30% of the entire basin area of the Nestos River. The results of the model application for the different years are given in Table 1.
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t \n\t\t\t\t \n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t \n\t\t\t\t \n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t \n\t\t\t\t \n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t \n\t\t\t\t \n\t\t\t\t | \n\t\t
1937 | \n\t\t\t366 000 | \n\t\t\t1950 | \n\t\t\t278 500 | \n\t\t\t1964 | \n\t\t\t91 000 | \n\t\t\t1977 | \n\t\t\t85 500 | \n\t\t
1938 | \n\t\t\t300 500 | \n\t\t\t1951 | \n\t\t\t428 500 | \n\t\t\t1965 | \n\t\t\t276 500 | \n\t\t\t1978 | \n\t\t\t280 500 | \n\t\t
1939 | \n\t\t\t271 500 | \n\t\t\t1952 | \n\t\t\t374 000 | \n\t\t\t1966 | \n\t\t\t475 500 | \n\t\t\t1979 | \n\t\t\t315 000 | \n\t\t
1940 | \n\t\t\t447 500 | \n\t\t\t1953 | \n\t\t\t359 000 | \n\t\t\t1967 | \n\t\t\t107 500 | \n\t\t\t1980 | \n\t\t\t314 000 | \n\t\t
1941 | \n\t\t\t144 500 | \n\t\t\t1954 | \n\t\t\t786 000 | \n\t\t\t1968 | \n\t\t\t252 500 | \n\t\t\t1981 | \n\t\t\t200 500 | \n\t\t
1942 | \n\t\t\t313 500 | \n\t\t\t1955 | \n\t\t\t381 000 | \n\t\t\t1969 | \n\t\t\t634 500 | \n\t\t\t1982 | \n\t\t\t209 500 | \n\t\t
1943 | \n\t\t\t36 000 | \n\t\t\t1956 | \n\t\t\t458 000 | \n\t\t\t1970 | \n\t\t\t152 500 | \n\t\t\t1983 | \n\t\t\t68 500 | \n\t\t
1944 | \n\t\t\t327 000 | \n\t\t\t1958 | \n\t\t\t413 000 | \n\t\t\t1971 | \n\t\t\t511 500 | \n\t\t\t1984 | \n\t\t\t185 000 | \n\t\t
1945 | \n\t\t\t485 000 | \n\t\t\t1959 | \n\t\t\t274 000 | \n\t\t\t1972 | \n\t\t\t179 000 | \n\t\t\t1985 | \n\t\t\t239 000 | \n\t\t
1946 | \n\t\t\t338 000 | \n\t\t\t1960 | \n\t\t\t555 500 | \n\t\t\t1973 | \n\t\t\t318 000 | \n\t\t\t1986 | \n\t\t\t511 000 | \n\t\t
1947 | \n\t\t\t517 500 | \n\t\t\t1961 | \n\t\t\t160 500 | \n\t\t\t1974 | \n\t\t\t225 000 | \n\t\t\t1987 | \n\t\t\t288 500 | \n\t\t
1948 | \n\t\t\t72 000 | \n\t\t\t1962 | \n\t\t\t798 500 | \n\t\t\t1975 | \n\t\t\t55 500 | \n\t\t\t1988 | \n\t\t\t253 000 | \n\t\t
1949 | \n\t\t\t230 500 | \n\t\t\t1963 | \n\t\t\t705 500 | \n\t\t\t1976 | \n\t\t\t319 500 | \n\t\t\t1989 | \n\t\t\t7 500 | \n\t\t
Computational results of sediment yield for the location “Momina Koula”
The mean annual value of sediment yield at the basin outlet, according to Table 1, is 315 000 t or 207.9 t/km2. This means that the mathematical model underestimates the measured mean annual sediment yield by about 18%. However, taking into account the overall assumptions of the mathematical model as well as the complexity of the simulated process, these arithmetic predictions can be considered to be acceptable.
The relatively low deviation between computation and measurement results for the mean annual sediment yield at the location “Momina Koula” was an encouraging indication for the further application of the simulation model to other parts of the Nestos River basin. The following calculations were therefore performed for a time period of 11 years (1980-1990), which corresponds to the period before the construction and operation of the considered reservoirs:
Calculation of mean annual sediment amount inflowing into the Thisavros Reservoir from the Bulgarian part (3052 km2) and from the Greek part (804 km2) of the Nestos River basin ([10]; [22])
Calculation of mean annual sediment amount inflowing into the Platanovrysi Reservoir from the corresponding basin (405 km2, Greece) [23]
In a previous study [24], the mean annual value of sediment yield at the outlet of the Nestos River basin (Toxotes) was calculated. Due to the construction and operation of the considered reservoirs, the sediment yield originates mainly from the part of the Nestos River basin which lies downstream of the Platanovrysi Reservoir (840 km2, Greece).
The calculated values of the annual sediment yield for different years at certain locations of the Nestos River basin (Thisavros Reservoir, Platanovrysi Reservoir, and Toxotes) are summarized in Table 2.
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t \n\t\t\t\t \n\t\t\t\t \n\t\t\t\t \n\t\t\t\t | \n\t\t\t\n\t\t\t\t \n\t\t\t\t \n\t\t\t\t \n\t\t\t\t \n\t\t\t\t | \n\t\t\t\n\t\t\t\t \n\t\t\t\t \n\t\t\t\t \n\t\t\t\t | \n\t\t\t\n\t\t\t\t \n\t\t\t\t \n\t\t\t\t | \n\t\t\t\n\t\t\t\t \n\t\t\t\t \n\t\t\t\t \n\t\t\t\t | \n\t\t\t\n\t\t\t\t \n\t\t\t\t \n\t\t\t\t \n\t\t\t\t | \n\t\t
1980 | \n\t\t\t1 084 000 | \n\t\t\t184 000 | \n\t\t\t154 500 | \n\t\t\t366 000 | \n\t\t\t278 000 | \n\t\t\t2 066 500 | \n\t\t
1981 | \n\t\t\t968 000 | \n\t\t\t128 000 | \n\t\t\t128 500 | \n\t\t\t344 000 | \n\t\t\t588 000 | \n\t\t\t2 156 500 | \n\t\t
1982 | \n\t\t\t850 000 | \n\t\t\t312 500 | \n\t\t\t112 500 | \n\t\t\t409 000 | \n\t\t\t426 000 | \n\t\t\t2 110 000 | \n\t\t
1983 | \n\t\t\t309 500 | \n\t\t\t114 000 | \n\t\t\t32 500 | \n\t\t\t99 500 | \n\t\t\t73 000 | \n\t\t\t628 500 | \n\t\t
1984 | \n\t\t\t678 500 | \n\t\t\t360 500 | \n\t\t\t107 500 | \n\t\t\t277 000 | \n\t\t\t494 000 | \n\t\t\t1 917 500 | \n\t\t
1985 | \n\t\t\t991 000 | \n\t\t\t94 500 | \n\t\t\t127 500 | \n\t\t\t54 500 | \n\t\t\t131 000 | \n\t\t\t1 398 500 | \n\t\t
1986 | \n\t\t\t1 495 500 | \n\t\t\t613 000 | \n\t\t\t162 000 | \n\t\t\t303 500 | \n\t\t\t198 000 | \n\t\t\t2 772 500 | \n\t\t
1987 | \n\t\t\t1 021 000 | \n\t\t\t875 500 | \n\t\t\t131 500 | \n\t\t\t761 500 | \n\t\t\t673 000 | \n\t\t\t3 462 500 | \n\t\t
1988 | \n\t\t\t884 000 | \n\t\t\t357 500 | \n\t\t\t130 000 | \n\t\t\t241 000 | \n\t\t\t383 000 | \n\t\t\t1 995 500 | \n\t\t
1989 | \n\t\t\t73 500 | \n\t\t\t121 000 | \n\t\t\txx | \n\t\t\t192 500 | \n\t\t\t207 000 | \n\t\t\t594 000 | \n\t\t
1990 | \n\t\t\t545 500 | \n\t\t\t552 500 | \n\t\t\t46 500 | \n\t\t\t289 500 | \n\t\t\t64 000 | \n\t\t\t1 498 000 | \n\t\t
Mean value | \n\t\t\t809 000 | \n\t\t\t337 500 | \n\t\t\t113 000 | \n\t\t\t314 500 | \n\t\t\t331 000 | \n\t\t\t1 873 000 | \n\t\t
Computational results of sediment yield at various locations of the Nestos River basin
For these calculations, the major assumption is that all sediments inflowing into the reservoirs are deposited in the reservoirs, which represents the most unfavorable case regarding coastal erosion. According to Table 2, the mean annual value of sediment yield at the outlet of the Nestos River basin before the construction of the dams (mean annual value of sediment yield at the outlet of the entire Nestos River basin) is about 1.9x106 t, while after the construction of the dams (mean annual value of sediment yield at the outlet of basin downstream of the Platanovrysi Reservoir) this amounts to 0.33x106 t. Therefore, it is evident that the construction and operation of the considered reservoirs has caused a dramatic decrease, of about 83%, in the sediments supplied directly to the basin outlet and indirectly to the neighboring coast. Since Nestos River constitutes one of the main sediment supply sources for the west and east parts of the coastal region in the vicinity of its delta, it is expected that the calculated reduction in the sediment yield that reaches the Nestos River mouth will influence the seashore sediment balance, and it may result in a considerable increase in the erosion rates of the Nestos River mouth and the adjacent shorelines.
The adopted shoreline change monitoring methodology for the Nestos River delta and the adjacent shorelines was the use of available high-resolution satellite images from the QuickBird (QB) satellite archive and aerial photographs from the Hellenic Military Geographical Service (HMGS), in conjunction with high-resolution GPS field measurements of the region [10]. In more detail:
Use of ortho-rectified/georeferenced satellite images that were available in the QB archive for the extraction of the shoreline in the year 2002. The spatial resolution of these satellite images is 0.6 m per pixel. The proposed year was selected, as it was more close to the years 1997 and 1999 of the construction and operation of the considered reservoirs.
Use of high-resolution DGPS field measurements for the extraction of the shoreline in the year 2007, in order to obtain the shoreline state approximately a decade after the operation of the considered reservoirs. The accuracy of these field measurements can reach the order of few centimeters.
Comparison of the extracted shorelines between these 2 years in order to access a short-term shoreline evolution of the region that can be considered to be the period after the construction of the dams.
Ortho-rectification/georeferencing of available, old aerial photographs of the region from the year 1945 from the HMGS and extraction of an old shoreline, approximately 50 years before the construction and operation of the reservoirs.
Comparison of the extracted shorelines between the years 1945 and 2002 in order to access a long-term shoreline evolution of the region that can be considered to be the period before the construction of the dams.
In order to test the accuracy of the adopted shoreline change monitoring methodology, this was first applied to a small part of the total pilot study region (Figure 2). The proposed test part is composed by the mainland shoreline at the west of Nestos River delta extending from the Akroneri Cape until the Keramoti Bay.
Pilot study region for shoreline change monitoring and selected region for testing the accuracy and effectiveness of the adopted shoreline change monitoring methodology
The main steps of the utilized methodology are outlined in the following subsections.
In order to use a common working subbase, an ortho-rectified background of the wider geographical region was created using various available topographic maps from the HMGS. The merging and ortho-rectification of the proposed maps was conducted in ArcMap software from the ArcGIS 9 package, using as Ground Control Points (GCPs) a wide number of known, benchmark trigonometric points of the region that were available by the HMGS.
The ortho-rectification of the available old aerial photographs of the region and the digital extraction of the corresponding shoreline was conducted with the ArcMap software of the ArcGIS 9 package. The basic stages of the proposed procedure are summarized below:
The aerial photographs were scanned and digitally imported into the ArcMap database in order to be ortho-rectified in the EGSA 87 coordinate system, using as GCPs points that were both visible in the aerial photographs as well as in the ortho-rectified map background. A total number of 6-8 GCPs were used for each aerial photograph.
A surface analysis was then performed in the aerial photographs and automatic contours were generated.
The contour that corresponded to the dividing line between land and sea pixels was manually selected by visual inspection and digitally extracted as the shoreline position in the year 1945.
Figure 3 (a) illustrates the digitally extracted shoreline for the testing region (year 1945) superimposed on the corresponding aerial photograph where the adequate accuracy and the validity of the extraction method described above can be clearly seen.
The digital shoreline extraction from the ortho-rectified, high-resolution, satellite images of the region was also conducted using the ArcMap software of the ArcGIS 9 package. The basic stages are summarized below:
Ortho-rectified, QB satellite images of the pilot study region were selected and ordered from the archive database of GEOMED LTD, one of the authorized resellers of these images, in Greece.
The proposed 4-band satellite images were then imported into the ArcMap database in the EGSA 87 coordinate system and adjusted to the infrared channel.
The well-known “Natural Breaks (Jenks)” pixel classification method was then applied on the images, from the “spatial analyst” tool of the ArcMap software, in order to separate sea and land pixels.
Then a contour line was automatically inserted at the interface of the classified sea and land pixels and digitally extracted as the shoreline.
Figure 3 (b) illustrates the digitally extracted shoreline for the testing region (year 2002) superimposed on the corresponding satellite image, where the adequate accuracy and the validity of the extraction method described above can be clearly seen.
(a) Digitally extracted shoreline from the aerial photograph that corresponds to the test region (year 1945), superimposed on the aerial photograph. (b) Digitally extracted shoreline from the high-resolution satellite images that correspond to the test region (year 2002), superimposed on the satellite image
The DGPS field measurements were conducted using a high-resolution DGPS system that consists of two GPS receivers. A static receiver that was installed at various, known, benchmark trigonometric points of the region that were preinstalled by the HMGS and a rover (mobile) receiver which was used for the surveying of the shoreline in the field. The recorded data points from the rover receiver along the shoreline were then postprocessed and extracted in AutoCAD files in the EGSA 87 coordinate system and finally imported superimposed at the ArcMap database. The accuracy of the DGPS measurements according to the specifications of the proposed equipment was of the order of few centimetres. However, this was double-checked and verified using GCPs with known coordinates.
In the present subsection, quantitative and qualitative results from the application of the proposed methodology to the entire pilot study region are presented and discussed in detail. Figure 4 illustrates indicatively some stages of the application for the entire pilot study area.
(a) Digitally extracted shoreline from aerial photographs (year 1945) for the entire pilot study region, superimposed on the aerial photographs. (b) Digitally extracted shoreline from satellite images (year 2002) for the entire pilot study region, superimposed on the satellite images. (c) Digitally extracted shoreline from DGPS measurements (year 2007) for the entire pilot study region, superimposed on the common working background
In order to investigate the erosion/accretion balance between the years 1945 and 2002 (time period before the construction of the dams) and the years 2002 to 2007 (time period after the construction of the dams), polygons that represent eroded and accreted areas were extracted from the ArcMap database. These are illustrated in Figure 5 for the two different time periods, respectively. The boundaries of these polygons are defined by the nonintersecting parts of the two digitally extracted shorelines in each of the examined time periods.
Eroded/accreted areas for the time periods 1945-2002 and 2002-2007
The resulting erosion/accretion balance expressed in m2 as well as in percentages relative to the total area, is summarized in Table 3.
\n\t\t\t\t | \n\t\t|
Erosion area (m2) | \n\t\t\tAccretion area (m2) | \n\t\t
1335027.90 | \n\t\t\t2242207.82 | \n\t\t
Erosion percentage (%) | \n\t\t\tAccretion percentage (%) | \n\t\t
37.32 | \n\t\t\t62.68 | \n\t\t
\n\t\t\t\t | \n\t\t|
Erosion area (m2) | \n\t\t\tAccretion area (m2) | \n\t\t
374892.96 | \n\t\t\t243453.14 | \n\t\t
Erosion percentage (%) | \n\t\t\tAccretion percentage (%) | \n\t\t
60.63 | \n\t\t\t39.37 | \n\t\t
Areas of erosion and accretion in the pilot study region, for the time periods 1945-2002 and 2002-2007
As it can be observed, from the year 1945 up to the year 2002 and for the considered shoreline (total length of 25 km), the erosion was about 1335028 m2 (23421 m2 per year) and the accretion 2242208 m2 (39337 m2 per year), i.e., the overall balance of the eroded/accreted areas from 1945 to 2002, indicates that accretion is the dominant mechanism covering a total area almost 1.7 times bigger than the corresponding area of the eroded parts. In other words, accretion dominates erosion by 25.36%. On the other hand, examining the same shoreline region from 2002 to 2007, the erosion was about 374893 m2 (74979 m2 per year) and the accretion 243453 m2 (48691 m2 per year), i.e., the erosion mechanism dominates accretion by approximately 21.26%. Therefore, it can be concluded that the dramatic decrease in the sediments supplied directly to the Nestos River basin outlet and indirectly to the neighboring coast, due to the construction and operation of the considered reservoirs, has almost inversed the previous state regarding the erosion/accretion balance in the considered region, just within 5 years of the construction of the dams. This finding evaluates the direct effect of the construction of the Thisavros and Platanovrysi Dams, to the erosion increase in the coastal region of the Nestos River delta and the adjacent shorelines.
As mentioned previously, for the purposes of the present investigation it was deemed appropriate to also extract a more recent shoreline (year 2013), in order to perform a comparison with the shorelines of the years 2002 and 2007, aiming at the quantitative investigation of the dynamic evolution of the examined coastal region, from the shoreline erosion point of view [14].
For this purpose, additional DGPS field measurements were conducted, following the same methodology and time period (spring) with the corresponding field measurements that were conducted in the year 2007. This more recent shoreline (2013) consists of three subregions: the Akroneri Cape region, the Keramoti Bay region and the region in the vicinity of the Nestos River delta.
The erosion/accretion balance between the shorelines of 2002-2007, 2007-2013, and 2002-2013 is illustrated in detail for these three subregions (Akroneri Cape in Figure 6, Keramoti Bay in Figure 7, and Nestos River delta in Figure 8).
As it can be macroscopically observed from Figure 6, in Akroneri Cape region, the eroded areas (red color) dominate the accreted areas (green color) in each one of the examined time periods. Examining both the subsequent periods 2002-2007 and 2007-2013 as well as in total the period from 2002 (considered period for reservoir construction and operation) to 2013 (most recent situation), in comparison with the initially examined period (2002-2007), it is characteristic that as years are passing, areas that in the first period were under relatively severe accretion are suffering in the subsequent periods from quite noticeable erosion.
Erosion (red color) /Accretion (green color) balance at Akroneri Cape region
Erosion (red color) /accretion (green color) balance at Keramoti Bay region
Almost the same trend is also observed in the region of Keramoti Bay, as it can be concluded by comparing the same time periods as previously (Figure 7). In more detail, while in the initial time period quite big areas of erosion as well as accretion can be traced, in the subsequent time period the areas that were initially under severe accretion, are now subjected to light accretion or even under considerable erosion. Accordingly, the areas that were initially subjected to considerable erosion, present now a more intense shoreline retreat.
Erosion/accretion balance in the region of the Nestos River delta
Regarding the region in the vicinity of the Nestos River delta, despite the fact that the shoreline presents a more intense and dynamic evolution, also in this case the initially presented (2002-2007) erosion/accretion balance in the subsequent time period (2007-2013) has been disturbed, indicating an increasing trend in the areas that are subjected to erosion with respect to the areas that are subjected to accretion.
All the above macroscopic observations are quantitatively summarized in Figure 9, where the percentages of erosion and accretion for the two subsequent time periods as well as for the entire examination period are depicted for each one of the examined regions.
Erosion (red color) /accretion (green color) percentages for the considered time periods, at Akroneri Cape region (a), at Keramoti Bay region (b) and the Nestos River delta region (c)
As it can be observed in all three considered regions, the erosion percentage in the time period 2007-2013 shows a significant increase in comparison with the previous time period (2002-2007). At Akroneri Cape region, an increase in the areas subjected to erosion by just 4% is observed. On the other hand, in the regions of Keramoti Bay and Nestos River delta, the corresponding increase reaches 23% and 24%, respectively, within just 6 years. It is also characteristic that in the case of the Nestos River delta, while in the time period 2002-2007 an erosion/accretion balance is observed, in the subsequent time period erosion predominates accretion by a considerable percentage. All the above quantitative observations can lead to the conclusion that the predomination of erosion with respect to accretion, after the construction and operation of the two reservoirs (year 2002), shows a continuously increasing trend.
In this third part of the present chapter, the effect of sediment removal by dredging and flushing from the Platanovrysi Reservoir downstream is investigated, in order to evaluate the increase in the sediment budget that reaches the outlet basin, as this increase can contribute to the reduction of shoreline erosion. For this purpose, the previously validated and applied mathematical model (RUNERSET - RUNoff ERosion SEdiment Transport) is modified accordingly in order to take into account sediment dredging and flushing applications. The proposed modifications involve the addition of different amounts of eroded material (sediment) in the subbasin that lies directly downstream of the Platanovrysi Reservoir for dredging processes as well as the inclusion of a flushing discharge. In more detail, a parametric investigation is conducted using a wide series of simulated scenarios, aiming to identify the optimum periods that dredging and flushing can be applied in order to maximize the increase of the sediment that is transported and reach the basin outlet [13].
In order to investigate the possible contribution of the mechanical removal (dredging) of sediment from the Platanovrysi Reservoir, and its deposition in the subbasin downstream of the Platanovrysi Dam, the mathematical model RUNERSET [10] was accordingly modified. In more detail, the proposed modification involves the addition of different, eroded sediment amounts in Subbasin 7 (Figure 1) for specific months of each year, for the time period 1980-1990.
A total number of 888 simulations were conducted for the years 1980-1990 assuming the following scenarios: application of dredging in each month of each year and for various amounts of sediment removal. Initially, diagrams of the total annual amount of sediment that reaches the basin outlet, versus the amount of sediment that was removed by dredging from the Platanovrysi Reservoir, were constructed. Figure 10 illustrates indicatively these diagrams for two of the considered years.
Indicative results from simulated dredging scenarios for the years 1981 (a) and 1986 (b)
From these diagrams it is obvious that for dredging scenarios in specific months of the year, the total annual sediment amount that reaches the basin outlet is higher than the corresponding amount in the rest of the months. Therefore, the months of the year can be clearly classified as “effective” and “ineffective” for a dredging application. In more detail, from the overall analysis of the simulation results, it can be concluded that January, February, March, April, November, and December can be, in general, characterized as “effective” months, while for the time period from May to October (ineffective months), a potential dredging application would not alter significantly the annual sediment amount that reaches the outlet of the river. The month classification in “effective” and “ineffective” is summarized schematically in Figure 11 (a), where the additional annual amount of dredged sediment that reaches Toxotes outlet of the river (Figure 1), is plotted against the amount of sediment that was removed in the specific month of the year in each case, for the overall simulated scenarios.
(a) Effective and ineffective months for dredging application, (b) Result of dredging application during the effective months of the year (the data points represent the overall simulated scenarios)
It has also to be mentioned that for amounts of sediment removal up to 35000 tn and for dredging scenarios in the effective months of the year, the ratio of the additional sediment amount that reaches Toxotes outlet, to the removed sediment amount, is equal to unity. This indicates that, generally, up to a limiting value of 35000 tn of dredged sediment from the Platanovrysi Reservoir, in an effective month, all of this removed amount of sediment will reach Toxotes outlet. Moreover, from a certain amount of removed sediment and above, there is not any change in the amount of sediment that reaches the basin outlet. This indicates that there is a maximum transport quantity of dredged material that the Nestos River can transport up to the basin outlet. This limiting amount varies accordingly for each month. Therefore, it is vital to define the month of the year in which this sediment transport quantity is maximized. Figure 11 (b) indicates that the maximum value of sediment surplus that reaches the basin outlet, takes place if dredging is applied in November.
However, for November there are also a lot of simulations that resulted in a zero sediment surplus at the basin outlet (in some of the overall simulated years). This means that while the Nestos River can transport the maximum amount of sediment that reaches the basin outlet, if the dredging application is performed during November for a certain year, it is also possible in a different year that no sediment at all reaches the outlet. Therefore, an additional classification of the “effective” months to “consistent” and “inconsistent” must be conducted. According to the diagram of Figure 11 (b), the months January and April can be characterized as “consistent,” while February, March, November, and December can be characterized as “inconsistent.”
In order now to investigate the most “effective” and “consistent” month of the year for applying sediment dredging, between January and April, a direct comparison of these two months was conducted. For this purpose, the overall results from all the simulated years (1980-1990) and for all the amounts of dredged sediment were collected, for January and April. The quantitative analysis of the proposed simulation results indicated that the overall sediment dredging performance of these two months could be classified into three distinct parts. The first part refers to dredging scenarios with sediment removal up to 34400 tn, in which the performance of each month with respect to the amount of sediment surplus that reaches the basin outlet is the same, having a value of 100%. The second and third parts consist of dredging scenarios with sediment removal from 34400 tn up to 36150 tn and greater than 36150 tn, respectively. In these last two parts of the collected data, the performance of each month is different, having values also lower than 100%. Taking into account the fact that the Nestos River cannot in general transport to the basin outlet dredged sediment amounts greater than 35000 tn, the third part of the resulting data was neglected from the comparison process. For the proposed comparison, the mean value of the dredged sediment amount that did not reach the basin outlet was taken as the effectiveness criterion, while the corresponding standard deviation was used as the criterion for consistency. The overall analysis from the comparison between January and April is summarized in Table 4. It is obvious that April can be assumed as the most suitable month of the year for a dredging application to the Platanovrysi Reservoir. It is also worth mentioning that the sediment amount of 35000 tn, that is, the maximum amount of dredged sediment that can reach the outlet of the Nestos River, is equal to 2.46% of the mean annual sediment yield of the river at its outlet, before the construction of the considered dams, and the 10.95% of the mean annual yield of the river after the construction and operation of the reservoirs. Finally, this sediment amount also constitutes the 11.53% of the mean annual sediment yield that reaches the Platanovrysi Reservoir.
\n\t\t\t | \n\t\t\t\t \n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t|||
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t||
34400 | \n\t\t\t27806 | \n\t\t\t6594 | \n\t\t\t34400 | \n\t\t\t0 | \n\t\t|
34625 | \n\t\t\t34626 | \n\t\t\t-1 | \n\t\t\t34625 | \n\t\t\t0 | \n\t\t|
34744 | \n\t\t\t27806 | \n\t\t\t6938 | \n\t\t\t34744 | \n\t\t\t0 | \n\t\t|
34825 | \n\t\t\t34825 | \n\t\t\t0 | \n\t\t\t34102 | \n\t\t\t723 | \n\t\t|
34903 | \n\t\t\t34902 | \n\t\t\t1 | \n\t\t\t34101 | \n\t\t\t802 | \n\t\t|
36150 | \n\t\t\t35238 | \n\t\t\t912 | \n\t\t\t36150 | \n\t\t\t0 | \n\t\t|
Mean value | \n\t\t\t34941.17 | \n\t\t\t32533.83 | \n\t\t\t\n\t\t\t | 34687 | \n\t\t\t\n\t\t |
Mean attribution [%] | \n\t\t\t– | \n\t\t\t93.11 | \n\t\t\t\n\t\t\t | 99.27 | \n\t\t\t\n\t\t |
\n\t\t\t | \n\t\t\t | Mean value | \n\t\t\t2407.33 | \n\t\t\tMean value | \n\t\t\t254.17 | \n\t\t
\n\t\t\t | \n\t\t\t | Standard deviation | \n\t\t\t3396.38 | \n\t\t\tStandard deviation | \n\t\t\t394.55 | \n\t\t
Comparison of effectiveness and consistency between January and March for dredging application
In order to investigate the possibility of minimizing shoreline erosion due to the construction of the proposed dams, with the application of flushing, the mathematical model RUNERSET was accordingly modified, in order to take into account the corresponding flushing discharge. Also in these series of simulations, the model was applied for the years 1980–1990. For the calculation of the flushing discharge, Equation (12) was used assuming that the sediment flushing discharge is known [11]:
where Qs is the removed sediment discharge from the reservoir during a flushing event (tn/s); S is the bottom slope along the flushing channel, assuming that the flow is uniform and therefore the slope of the energy line and the flow line coincide; and Qf: is the flushing discharge (m3/s).
In order to determine the optimum month of the year for the application of flushing in the Platanovrysi Reservoir, a series of simulations were performed with a sediment flushing discharge of 0.0135 tn/s (that corresponds to the value of 35000 tn) and for flushing events occurring in different months. The results are summarized in Table 5.
\n\t\t\t | \n\t\t\t\t | \n\t\t||||||||||
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t|
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t
\n\t\t\t\t | \n\t\t\t95.71 | \n\t\t\t73.78 | \n\t\t\t90.94 | \n\t\t\t93.72 | \n\t\t\t0.00 | \n\t\t\t99.99 | \n\t\t\t0.00 | \n\t\t\t0.00 | \n\t\t\t84.48 | \n\t\t\t90.86 | \n\t\t\t90.97 | \n\t\t
\n\t\t\t\t | \n\t\t\t99.99 | \n\t\t\t35,20 | \n\t\t\t100.00 | \n\t\t\t100.00 | \n\t\t\t0.00 | \n\t\t\t24.55 | \n\t\t\t83.59 | \n\t\t\t99.99 | \n\t\t\t0.00 | \n\t\t\t100.00 | \n\t\t\t100.00 | \n\t\t
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t
\n\t\t\t\t | \n\t\t\t34.26 | \n\t\t\t21.77 | \n\t\t\t24.06 | \n\t\t\t22,88 | \n\t\t\t21.46 | \n\t\t\t21.98 | \n\t\t\t21.58 | \n\t\t\t22.54 | \n\t\t\t27.61 | \n\t\t\t21.70 | \n\t\t\t21.55 | \n\t\t
\n\t\t\t\t | \n\t\t\t20.83 | \n\t\t\t20.91 | \n\t\t\t20.92 | \n\t\t\t0.00 | \n\t\t\t20.89 | \n\t\t\t20.83 | \n\t\t\t23.58 | \n\t\t\t23.68 | \n\t\t\t0.00 | \n\t\t\t20.84 | \n\t\t\t20.86 | \n\t\t
\n\t\t\t\t | \n\t\t\t21.40 | \n\t\t\t21.48 | \n\t\t\t21,78 | \n\t\t\t7.45 | \n\t\t\t21.46 | \n\t\t\t21.69 | \n\t\t\t22.43 | \n\t\t\t21.68 | \n\t\t\t21.61 | \n\t\t\t21.70 | \n\t\t\t21.55 | \n\t\t
\n\t\t\t\t | \n\t\t\t21.40 | \n\t\t\t21.48 | \n\t\t\t21.49 | \n\t\t\t21.56 | \n\t\t\t21.46 | \n\t\t\t21.69 | \n\t\t\t21.58 | \n\t\t\t21.68 | \n\t\t\t21.61 | \n\t\t\t21.70 | \n\t\t\t21.55 | \n\t\t
\n\t\t\t\t | \n\t\t\t20.83 | \n\t\t\t20.91 | \n\t\t\t20.92 | \n\t\t\t20.85 | \n\t\t\t20.89 | \n\t\t\t20.83 | \n\t\t\t20.72 | \n\t\t\t20.82 | \n\t\t\t20.75 | \n\t\t\t20.84 | \n\t\t\t20.86 | \n\t\t
\n\t\t\t\t | \n\t\t\t21.40 | \n\t\t\t21.48 | \n\t\t\t21.49 | \n\t\t\t21.56 | \n\t\t\t21.46 | \n\t\t\t21.69 | \n\t\t\t21.58 | \n\t\t\t21.68 | \n\t\t\t20.75 | \n\t\t\t0.00 | \n\t\t\t21.55 | \n\t\t
\n\t\t\t\t | \n\t\t\t92.56 | \n\t\t\t0.00 | \n\t\t\t68.36 | \n\t\t\t99.15 | \n\t\t\t97.48 | \n\t\t\t99.99 | \n\t\t\t97.59 | \n\t\t\t13.68 | \n\t\t\t99.91 | \n\t\t\t0.00 | \n\t\t\t97.45 | \n\t\t
\n\t\t\t\t | \n\t\t\t0.00 | \n\t\t\t0.00 | \n\t\t\t0.00 | \n\t\t\t81.18 | \n\t\t\t100.00 | \n\t\t\t99,99 | \n\t\t\t99.88 | \n\t\t\t0.00 | \n\t\t\t0.00 | \n\t\t\t94.00 | \n\t\t\t14.58 | \n\t\t
Results from simulations of flushing scenarios for different months of the year
It is obvious that the optimum month for the application of a flushing event, in order to maximize the overall flushed sediment amount that reaches the basin outlet, and therefore decreases the indirect shoreline erosion, is January and not April (as in the corresponding investigation for the application of dredging). However, April is found to be the second most effective month. In the literature it is stated that in order to maximize the amount of sediment that is removed from a reservoir and therefore restore its storing capacity, a flushing event will be more effective if it occurs at the beginning of the ice melting period [11]. Therefore, from this point of view, April could be characterized as the optimum month of the year for the application of a flushing event.
In order to calculate the river’s maximum transport quantity of flushed sediment at the outlet of its basin, additional scenarios of continuous through each year flushing events were simulated. For this purpose, the mathematical model RUNERSET was further modified in order to take into account sediment flushing discharge equal to 0.1 tn/s, a value much greater than the previously identified critical value of 0.0135 tn/s. From the analysis of the results it is found that the Nestos River could transport to the basin outlet approximately 200000 tn of additional sediment, if the flushing of sediment was applied continuously during the whole year. It is worth mentioning that this amount constitutes the 62% of the mean annual sediment yield today.
Taking into account that the application of flushing could be more effective, at least from the point of view of limiting shoreline erosion, during certain months of the year (time period from November to April), additional continuous flushing scenarios were simulated for the period of the six more effective months of the year for each of the considered years (1980-1990). The overall results are summarized in Figure 12.
Results from simulated flushing scenarios
Examining Figure 12, it can be concluded that in the case that the continuous flushing event happens during the six of the most effective months of the year, the amount of sediment that reaches the basin outlet of the Nestos River reaches the 76.5% of the corresponding amount in the case of continuous flushing throughout the whole year. Moreover, in the case that the sediment flushing event is applied only during January the amount of sediment that reaches the outlet constitutes the 17.35% of the maximum possible amount (continuous flushing throughout the year). This amount is also equal to the 73.5% of the amount that would reach Toxotes outlet, in the case of a continuous flushing event during the noneffective months of the year (period from May to October).
In order to select the optimum of the two examined methods, a comparison was conducted by collecting the maximum amount of sediment that reaches the basin outlet of the Nestos River, that are attributed, if each method is applied in its optimum identified month of the year; April for the application of mechanical sediment removal, and January for the application of sediment flushing.
In order to calculate these quantities, a sediment discharge (dredging/flushing) greater than the previously used values of 35000 tn for the case of dredging and 0.0135 tn/s for the case of flushing was assumed. In more detail, the mathematical model was further modified in order to take into account a sediment discharge of Qs=289200 tn and qsf=0,1 tn/s, since it was proven that for values generally above 35000 tn (approximately 0.0135 tn/s for the case of a flushing event with a duration of 30 days), the results of the simulations did not change. The results of the proposed comparison are summarized diagrammatically in Figure 13.
Comparison between dredging and flushing
It can be seen that flushing seems to perform slightly better than dredging but in a degree that cannot be chosen as the optimum method. Therefore, in order to choose the optimal method for the aim of the present investigation, other criteria such as technical difficulties in their application as well as cost of application should be taken into consideration.
Coastal erosion that is generated by the reduction of the annual sediment yield at river outlets due to the construction of dams constitutes one of the main environmental problems in many parts of the world. Nestos is one of the most important transboundary rivers, characterized by its great biodiversity. The Nestos River flows through two European countries, Bulgaria and Greece, and discharges its water into the Aegean Sea. In the Greek part of the river, two dams, the Thisavros Dam and the Platanovrysi Dam, have already been constructed and started operating in 1997 and 1999, respectively. The construction of the dams implies a reduction of sediment yield at the outlet of the Nestos River basin and the alteration of the sediment balance of the basin in general, which results in coastal erosion.
The present chapter deals with the assessment of reservoir sedimentation effect on the coastal erosion for the case of the Nestos River delta and the adjacent shorelines, through mathematical modeling, remote sensing techniques, and field surveying. The mathematical model is applied for the estimation of the sediment yield reduction at the outlet of the river due to the subsequent sediment accumulation within the reservoirs, while a shoreline change monitoring methodology is applied for the estimation of the alteration of the erosion/accretion balance in the wider coastal region of the Nestos River delta, examining the proposed balance in two different time periods, before and after the construction of the dams.
The mathematical model results indicate that the construction of the considered dams has caused a dramatic decrease (about 83%) in the sediments supplied directly to the basin outlet (delta) and indirectly to the neighboring coast. Comparing the overall balance of the eroded and accreted areas in the region, before and after the construction and operation of the reservoirs, it can be concluded that the decrease in the sediments supplied directly to the Nestos River basin outlet and indirectly to the neighboring coast, has almost inversed the previous situation (where accretion predomin;ated erosion by 25.36%), just within 5 years of the construction of the reservoirs, with erosion now predominating accretion by 21.26%. The extraction of a more recent shoreline and the corresponding comparison with the previously identified shoreline states clearly indicates a continuously increasing trend in the predomination of erosion in relation to accretion.
Based on the above, it emerges that the construction and operation of the Thisavros and Platanovrysi Reservoirs have significantly increased coastal erosion in the Nestos River delta and the adjacent shorelines. This fact, together with the anticipated rise of sea level, may pose a great problem to the coastal area resources, threatening the local communities and ecosystems of the considered region. Therefore, it is necessary to further investigate the sediment budget within the estuarine and the adjacent coastal systems and to further monitor erosion/accretion trends of the region for the coming decades.
In the present chapter also, a previously validated and applied mathematical model is modified accordingly in order to take into account the application of sediment dredging and flushing in a reservoir of river hydrological basin. The modified model is applied for the case of the Nestos River (Greece) in order to identify the optimum sediment removal scenario in a certain reservoir (Platanovrysi Reservoir) upstream of the considered river outlet (Toxotes outlet), in order to maximize the amount of sediment that reaches the delta of the river. In more detail, a wide series of parametric simulation scenarios is performed, aiming to identify the optimum periods that the dredging and flushing can be applied. From the overall analysis of the simulation results, a definite classification of the months into “effective” and “ineffective” as well as into “consistent” and “inconsistent” with respect to the total amount of removed sediment that reaches the basin outlet is made. It is also found that the considered river has a maximum transport capacity of the removed material, regardless of the further increase of the dredged and/or flushed sediment capacity from the identified limiting value. A comparison between the two considered methods identified flushing to be slightly more effective than dredging.
Finally, the overall results of the present investigation indicate that the proposed modified mathematical model can serve as a quite effective and useful tool that can be applied for similar investigations at various river basins worldwide and it could also be incorporated into the early design stages of new reservoirs that are going to be constructed, estimating the amount of sediment discharge that needs to pass through the reservoir in the downstream part of the river basin in order to minimize the unavoidable deltaic and adjacent shoreline erosion.
The authors would like to acknowledge the financial support from the Research Project, INTEREG IIIC BEACHMED-e, “Strategic management of beach protection for sustainable development of Mediterranean coastal zones.”
Dementia is a major cause of morbidity and mortality in the developed world. Dementia, in all of its forms, is a progressive condition, with an incidence of less than 5% through age 79, but reaching 40% for those over age 90 [1]. Given the aging demographics of the developed world, the economic impact of this condition could soon dominant healthcare costs in many countries.
There is currently no cure for dementia, and numerous pharmaceutical firms have abandoned the search for a cure. In particular, interventions based on the beta-amyloid hypothesis which has guided dementia drug therapy development for the last three decades has come under increasing scrutiny as drugs which effectively reduce beta-amyloid accumulation appear to exacerbate, rather than ameliorate, the symptoms associated with dementia [2]. It is therefore incumbent that we take a fresh approach to understanding dementia, in particular, we suggest it is important to develop a more thorough understanding of the numerous physiologic interactions associated with progression of cognitive impairment with age. Such understanding will set the stage for innovative interventions, specifically, interventions focused on prevention, rather than treatment. This coupled systems, or complex systems, approach, is less intuitive than the more traditional scientific approach of establishing proximate cause. Indeed, in complex systems, cause may not be identifiable, rather, outcomes arise as emergent behaviors of interdependent coupled components of the system. Despite these challenges, it is becoming widely recognized that a complex systems mindset will be necessary for effectively addressing not only dementia, but also the wide range of functional disorders which modern medicine currently faces [3].
Perhaps the physiologic interactions of greatest current interest, with respect to dementia, are those between the cardiovascular and cerebral systems. Over the past three decades, numerous prospective and retrospective studies have identified strong associations between low cardiac output, low blood pressure, low cerebral perfusion, and the development of dementia. The majority of these studies have focused on older adults, but a review of cognitive and cardiovascular changes taking place from early adulthood provides important insights into why dementia may not have to be the scourge of old age which many people fear.
Here, we describe the development of cognitive decline starting in early adulthood and relate this decline to parallel changes in the cardiovascular and the musculo-skeletal systems, specifically, second heart function. The parallels in secular decline in these systems lead us to propose that inactivity based changes in skeletal muscle fiber structure plays a critical role in the age related decline in cardiac output, and correspondingly decreased cerebral blood flow. We propose that this decreased cerebral blood flow, beginning in middle age, is a dominant factor in cognitive decline, cognitive impairment, and eventually dementia, in those where cerebral perfusion is not corrected. We introduce preliminary evidence showing that enhancement of cardiac output through second heart (soleus muscle) stimulation is able to improve cognitive performance in those with both mild and advanced cognitive impairment.
Dementia is a syndrome characterized by memory loss, decline in executive function, behavioral changes, and ability to perform activities of daily living. The impact of dementia on the healthcare system is by far the highest of any health condition [4]. In the U.S., for example, cumulative five year care costs exceed $300,000 or roughly twice the cost of care for heart disease or cancer. With almost 6 million Americans currently affected, annual costs to Medicare/Medicaid exceed $300 billion, and with the aging of the population, these costs are expected to exceed $500 billion by 2040, unless an effective intervention is developed.
While prevalence within the elderly population is based on diagnosed cases, it has become clear that dementia is a slowly progressive condition initiated at a far earlier stage of life. For example, in our laboratory, we have utilized computer aided assessments (Cognivue, Inc., Victor, NY) to quantify cognitive function, including memory, motor skills, and executive function. We have observed (Figure 1) that by age 65, cognitive performance for more than 50% of individuals falls below established threshold for mild cognitive impairment. Moreover, by age 80, roughly one-half of the individuals we have screened in our laboratory score below the threshold for moderate to severe cognitive impairment.
Age related decline in cognitive performance (memory, motor, and executive function) in a convenience sample of middle aged and older subjects. By age 65, more than half of tested subject perform at a level characterized as mild cognitive impairment or worse. For those in their mid 80s or older, more than half perform at a moderate to severe cognitive impairment level.
Remarkably, we observe few individuals over the age of 55 who are able to score above 90 on the Cognivue scale (scores above 95 are readily attained by young adults). Linear regression leads to the suggestion that cognitive decline is initiated while individuals are still in their 30s. This perspective is confirmed by the work of Hughes et al. who have investigated cognitive performance among middle-aged and older individuals through the use of telephone-based assessments [5]. In assessing over 2500 individuals using a range of validated assessments, small declines in cognitive performance were observed as people progressed from their 30s into the 40s, however, only one assessment (backwards counting) showed a significant decline in performance over this decade. Starting in the 40s, dramatic declines became evident relative to that of individuals in their 30s (Figure 2).
Decline in cognitive function in middle aged adults. In phone evaluations of over 2500 middle aged and older adults, significant decline in backward counting capability becomes evident between 30 and 40 years of age. Beyond age 40, the majority of cognitive skills are found to decline, and beyond age 50, all cognitive skills evaluated decline with increasing age. After Hughes, et al., [
The characteristics of cognitive performance decline appear to be dependent on cognitive task. Short-term memory skills, such as repeating a digit sequence backward, declined slowly with age, along with immediate recall tasks. However, executive function tasks were found to already show substantial decline in early middle age.
The question naturally arises as to whether these observed “declines” in cognitive performance in middle-age individuals are, in fact, detrimental, or instead simply reflect more effective use of “brain power” which comes with experience. That is, individuals consistently show improved performance in day to day functions in this age range despite the decline observed in cognitive testing [6]. A generally accepted explanation for this apparent paradox is that, for young people, most daily experiences are novel, and so they retain a high ability to deal with novel exposures. Alternatively, by middle age, most people have obtained a knowledge base of serviceable answers to the most commonly encountered mental challenges, which they can recover with minimal cognitive effort. Because cognitive testing, by design, relies on the presentation of novel challenges, this gives young individuals a natural advantage independent of actual levels of cognitive capability. Certainly, many individuals retain “normal” levels of cognitive performance as measured by cognitive testing well into their 80s, as seen in Figure 1, perhaps indicating that these individuals have retained the ability to deal with fresh challenges through regular exposure to novel experiences.
Nonetheless, the consensus in the healthcare community is that while dementia is not a normal outcome of aging, some cognitive decline is to be expected with aging. Age related changes in cardiovascular system performance provides a physiologic basis for this consensus. Specifically, cardiac output has long been observed to decline with age. However, early demonstrations of this declining pattern have relied on invasive measurement techniques which were capable of creating a stress response which may have influenced these older measurements. To address this issue, Middlemiss, et al. [7] have recently utilized non-invasive cardiac output assessment techniques to evaluate changes in cardiac output across the adult age span (Figure 3).
Cardiac output (CO) as a function of age as measured utilizing non-invasive assessments. Cardiac output declines by approximately 50% in both men and women from the 3rd decade to 9th decade of life. CO decline occur at a relatively constant rate over this age range.
These non-invasive measures confirm that cardiac output in the supine position declines substantially with age, specifically by almost 50% over the adult life span in both men and women. Moreover, these investigation shows that cardiac output declines by a further 25% during transition from the supine to the seated position, and falls by 50% when transitioning from supine to a standing position. The implication is that cardiac output in older adults who are standing quietly can be expected to be reduced, on average, by 75% in comparison to that of an average 20 year old.
Cardiac output is a key determinant of arterial blood pressure. In combination with peripheral vascular resistance, cardiac output establishes mean blood pressure. As sufficient blood pressure must be sustained throughout the cardiac cycle in order to ensure adequate blood flow to the brain, which is located at the top of the body when in upright posture, blood pressure becomes a critical factor in regulating cognitive performance. In principle, the declining cardiac output associated with aging should not necessarily lead to declining blood pressure, as vasoconstriction can raise peripheral vascular resistance in order to maintain blood pressure levels. In fact, given the dramatic decline in cardiac output when upright, in the majority of older individuals the ability to vaso-constrict is insufficient to maintain normal blood pressure.
In our lab, we focus on assessing resting diastolic blood pressure (DBP), as the lowest pressure during the diastolic phase of the heart contraction cycle represents the point at which cerebral blood flow is at a minimum. We obtain resting DBP with the subjects in a quiet, seated position for at least 10 minutes, and record the third of three brachial pressure measurements. We observe (Figure 4) that by age 55, average resting DBP is below 80 mmHg. By the 9th decade of life, average diastolic pressures are below 70 mmHg. Overall, we observe that among this convenience sample that approximately 20% are unable to maintain a resting diastolic pressure above 65 mmHg, a level at which symptoms of orthostatic hypotension (OH) become evident. For subjects over the age of 75, 30% are unable to maintain this threshold DBP level.
Resting diastolic blood pressure (DBP) vs. age. A robust negative correlation (p < 0.0005) is observed between DBP and age with average DBP falling below 80 mmHg by age 55 in a convenience sample of men and women. By age 85, average DBP falls below 70 mmHg, and within the subject population, approximately 20% were unable to sustain a DBP above 65 mmHg after sitting for 10 minutes.
OH has been shown to occur in less than 3% of young adults, but up to 35% in individuals over the age of 75 [8]. Torabi, et al. [9] investigated the cardiovascular characteristics of individuals with both classical and delayed OH. In a study of over 2000 patients, over the age of 15, with unexplained syncope, 27% were found to be unable to maintain normal blood pressure levels during upright tilt testing. In this population, systolic blood pressure fell, on average to 95 mmHg, while diastolic blood pressure fell, on average, to 60 mmHg.
These observations indicate that asymptomatic postural hypotension is remarkably common in the adult population. That is, vaso-constrictive ability is insufficient in at least 20% of the adult population to maintain normal blood pressure during quiet sitting. Moreover, among the older population, symptomatic postural hypotension is evident in over one-third of individuals, who are unable to maintain blood pressure levels in the presence of declining cardiac output. The critical question is whether the health implications associated with chronic hypotension extend beyond the inconveniences of dizziness and occasional syncope. Extensive work on the association of hypotension with cognitive impairment suggests that hypotension, and correspondingly, cerebral hypo-perfusion, may be one of the most consistent risk factors associated with dementia.
Numerous lines of evidence lend strong support for the hypothesis that sustained cerebral hypo-perfusion as a result of chronically low blood pressure has significant negative effects on cognitive performance, and as well, leads to the development of dementia.
Recent computer aided cognitive assessments of men and women over the age of 50, for example, demonstrate a strong correlation between resting diastolic pressure and cognitive performance (Figure 5). Multivariate regression analysis on these data show that, after adjusting for subject age, resting diastolic pressure is a significant (p < 0.02) predictor of cognitive performance with close to a 1% decline in performance for each 1 mmHg drop in DBP. Notably, only for average diastolic blood pressures above 80, is normal cognitive performance (assessment score > 75) observed. Similarly, the regression analysis indicates that for diastolic pressures below 50 mmHg, average cognitive performance falls into the moderate cognitive impairment range.
Cognitive performance vs. resting diastolic blood pressure (DBP). After adjusting for age effects on cognition, declining DBP is strongly associated with declining cognition levels in a convenience sample of men and women. The average individual with a resting DBP below 80 mmHg falls into the category of mild cognitive impairment as assessed using the computer aided Cognivue assessment. DPB below approximately 50 mmHg is associated with transition into the range of moderate to severe cognitive impairment.
These results are consistent with those first reported in the Baltimore Longitudinal Aging Study [10] where it was found that cognitive performance in an older (70 ± 8 years) population was significantly degraded at diastolic blood pressures below 80 mmHg. Confirmation is also obtained by comparison of age dependent cardiovascular and cognitive performance measures (Figure 6). Combining the results of Middlemiss et al. [7] with the results of Hughes et al. [5] demonstrates a robust (p = 0.002) association between cognitive performance and cardiac output. This analysis demonstrates that for a 30% decline in cardiac output, a 40% decline in cardiac performance can be expected in the 40–90 year old population.
Integrated analysis of age related cognitive performance data per Hughes et al. [
Over the past two decades, numerous studies have provided substantial evidence that decreased cardiac output and chronically low blood pressure are associated with declines in cognitive performance, and also significantly increases the risk of developing dementia. Among the earliest of these studies was the Kugsholmen project undertaken in Sweden [11]. This study showed that, in an elderly population, those with a systolic blood pressure below 140 mmHg, or a diastolic blood pressure below 75 mmHg, had a 3x greater likelihood of being diagnosed with dementia. At that point in time it was unclear whether the lower blood pressures were a consequence of dementia, or played a causal role.
The East Boston study [12] addressed, in part, this question, by showing that there was an inverse correlation between risk of Alzheimer’s diagnosis and blood pressures taken four years before diagnosis. Verghese, et al. [13] subsequently directly addressed this question in the Bronx Aging Study. They observed in this community based, longitudinal study that sustained low diastolic blood pressure (<70 mmHg) was associated with a 2x increased risk of developing Alzheimer’s disease over a 20 year period. More recently, in a cross-sectional study of more than 24,000 adults who did not have a dementia diagnosis, subjects were followed for up to 27 years [14]. Applying multiple linear regression to adjust for age, gender, education, and body mass index, significant negative correlations were observed between risk of developing Alzheimers, as well as all-cause dementia, across the full range of systolic and diastolic blood pressures.
Complementing these investigation, the established link between diabetes and risk of dementia [15], combined with the well-known influences of diabetes on vascular dysfunction, is currently leading to a broader acceptance that hypo-metabolism, and correspondingly, hypo-perfusion, plays a more significant role in the development of dementia than previously considered [16].
The numerous demonstrated associations between declines in cardiac output, blood pressure, cognitive performance, and risk of developing dementia, provides a physiologic explanation for the age related cognitive decline, but provides limited insight into how this decline could be prevented or reversed. Our research has led us to propose that the critical factor linking these related outcomes is the inability to maintain adequate venous return during orthostasis.
Venous return refers to the flow of blood from the periphery of the body back to the right atrium. While venous return and cardiac output levels can transiently deviate, under normal physiologic conditions cardiac output is strictly a function of venous return. In the supine position, venous resistance contributes only about 15% to total vascular resistance, however, in upright posture, the venous system plays a much larger role in influencing venous return.
The largest influence of the venous system is through its role as a capacitance vessel. Veins are highly distensible, having thinner walls, with larger diameters, and a compliance of about 30 times that of arteries. They can, therefore, expand rapidly to accommodate large volumes of blood. Correspondingly, a transition from supine to upright posture typically leads to a rapid 500 ml redistribution of blood to the peripheral venous system, a fluid shift which continues to increase over time. The ratio of venous to arterial capacitance under orthostasis has been estimated to grow to as large as 18:1 [17].
In addition, the influence of gravity on the hydrostatic column of blood in the venous system is such that venous blood pressure in the feet can exceed 90 mmHg. As a result of these high lower limb pressures, fluid extravasation from the vascular system increases. Increased extravasation can lead to an additional loss of up to 750 ml over 30–40 minutes following the transition to upright posture. Not only does this cause a further decrease in circulatory system blood volume, but also increased interstitial fluid pressure which results in compression of the peripheral vasculature, and increased in vascular resistance.
The net effect of reduced circulatory volume and increased vascular resistance during upright posture is significantly decreased cardiac output. While vaso-constriction serves to partially support blood pressure during orthostasis, this additional increase in vascular resistance also serves to further reduce blood flow. In our lab, we have observed average sustained decreases in cardiac index, resulting from a transition to quiet sitting, of over 35% relative to that supported when individuals were supine (Figure 7).
Cardiac index as a function of time following transition from supine to upright sitting. A decline in CI of 36% from a supine CI of 3.4 L/min/m2 is observed among healthy adult women with an average age of 62. This occurs despite an increase in metabolic rate associated with an upright posture, and arises due to gravity induced blood pooling in the lower exptremities.
Return of pooled blood and interstitial fluid which occurs during orthostasis is critically dependent on skeletal muscle pumping. While locomotion can play a role in this process, most adults are sedentary for 9–10 hours per day [18]. Under sedentary conditions, skeletal muscle pumping activity is dominated by soleus muscle action. The essential role played by the soleus in ensuring venous and lymphatic return during orthostasis has led to these muscles commonly being referred to as the calf muscle pumps, or the “second hearts.”
The soleus muscles are highly specialized muscles which contain up to 18 thin walled sinuses, each of which are able to hold large volumes of blood. Further, as deep postural muscles composed primarily of slow-twitch fibers, the soleus muscles can sustain contractions over extended time periods. A typical soleus contraction cycle lasts up to one minute, followed a relaxation phase of 60–90 seconds during which the sinuses are able to refill. In addition, because the soleus muscles originate on the posterior tibia and fibula, the muscle can pump effectively when a person is seated. These muscles can generate venous driving forces exceeding 200 mmHg, more than sufficient to drive blood and interstitial fluid back to the heart during upright posture.
Like all muscle tissues, the soleus muscle demonstrate changes in both structure and physiology with increasing age. The most commonly observed change in voluntary muscle with advancing age is reduction in muscle mass, with Type II muscle fibers decreasing in both numbers and in volume with age [19]. However the soleus muscle is a deep postural muscle and principally composed of Type I fibers, and Type I fibers do not change substantially in size or number with advancing age. Rather, Type I fibers are far more affected by usage patterns.
Specifically, lack of use of the soleus muscle results in fibers converting towards Type II behavior. Microvascular supply to the fibers is lost and correspondingly, the innate fatigue resistance expected in deep postural muscle tissue. This transition can occur rapidly, independent of age. NASA studies characterizing muscle fiber type changes in astronauts found more than a 20% loss in force generating capacity in both Type I and Type IIa fibers taken from the soleus after a remarkably short (17 day) space flight [20].
The postural role of the soleus muscle is plantar flexion. In fact, when an individual is in a bent knee position, the soleus is the only active plantar flexion muscle. The postural activities which require the most significant plantar flexion force in the bent knee position are squatting activities. Squatting is the natural human rest position, and our ancestors squatted regularly throughout the day - while cooking, eating, socializing, and of course, when defecating. Children also commonly squat during the day, but in the modern world, sitting has become the dominant resting position. While a small level of soleus activity occurs during sitting, squatting results in 4–5 times as much soleus muscle activity as sitting [21]. Therefore, while our ancestors were typically sedentary for 9 or more hours each day, similar to modern individuals, their natural resting posture required up to 5x more soleus muscle activity, thereby persevering the fatigue resistant qualities of the slow twitch muscle fibers in this muscle.
The critical observation is that the commonly observed declines in the venous return of adults is not a function of age, per se, but rather is the result of the transition to sitting as a dominant resting posture, in particular as people get older. The transition to sitting as the dominant upright resting posture for adults has resulted in two significant impacts on venous return. First, the soleus muscles are activated for only a small fraction of the time when people are sedentary, and correspondingly, muscle pump activity is limited. Second, soleus inactivity results in an adaptation of the soleus muscle fibers such that the muscle, even when activated, is unable to develop the sustained forces necessary to ensure adequate venous return.
Because the soleus fiber adaptations which occur in most people arise primarily from disuse and not due to aging, reconversion of the soleus muscle fibers back to Type I fibers should be possible through alteration of muscle activation patterns. The soleus muscles are activated, when in upright posture, when the center of gravity of the body moves too far forward; soleus contraction returns the body to a balanced position. This shift in the center of gravity is sensed by pressure on the frontal plantar surface, specifically by Meissner’s Corpuscles, which activate short, and long, loop reflex arcs which trigger soleus contraction.
Retraining of the soleus muscle fibers therefore should simply require a sustained stimulation of the postural reflex arc in a pattern which mimics normal resting posture (i.e. squatting) activation. This can be achieved using micromechanical stimulation of the Meissner’s Corpuscles periodically for sustained periods of time (one minute bouts) for extended time periods, over the course of the day (i.e. a significant fraction of sedentary time).
In our lab, we have undertaken such studies utilizing the soleus muscle stimulator (HeartPartner) developed by Sonostics, Inc. (Endicott, NY). We utilize electrical impedance plethysmography (Cheetah Medical; Wilmington, DE) to track cardiac output following a transition from the quiet standing position to quiet sitting. This represents a change in metabolic activity from about 1.74 METS to about 1.46 METS [22] or roughly a 17% decline in metabolic demands and therefore cardiac output (CO). Typically, the decline observed in adults in far greater. Figure 8 provides an example of the observed cardiac performance in response to this shift in posture in an older adult. From an initial cardiac index (CI=CO/Body Surface Area) of 2.8 L/min/m2, cardiac output drops by almost 40% during 60 minutes of quiet sitting.
Cardiovascular system response to soleus muscle stimulation in a 60 year old woman. A change in posture from standing to sitting results in this individual results in a 40% decline in cardiac index (CO/BSA) whereas 20% or less would be expected. While quiet sitting is incapable of stimulate the soleus muscles sufficiently to maintain the venous return necessary to sustain a normal level of cardiac output, external stimulation of the soleus muscles is seen to be capable of returning cardiac output to normal levels within 30 minutes. Initial abrupt rise in CI reflects return of blood pooled into lower limb veins, while the slower rise in CI reflects interstitial fluid return through the lymphatics.
These results demonstrate that, when seated, the soleus muscles are commonly not being stimulated sufficiently to sustain the venous return necessary to maintain normal cardiac output (CO). However, the soleus muscles still respond, at least over a relatively short duration (30 minutes), to external stimulation. The initial (within minutes) response to soleus stimulation is a rapid rise in cardiac output due to the return of blood pooled into the lower leg veins. Over tens of minutes, interstitial fluid return through the lower limb lymphatics serves to further increase cardiovascular volume resulting in a return to a cardiac output level expected for a sitting adult.
Importantly, just as the soleus muscle rapidly adapts to disuse, these muscles appear to be capable of rapidly “readapting” or more specifically, undergoing muscle fiber reconversion. Figure 9 (left panel) illustrates the cardiovascular response to the orthostatic stress of quiet sitting in a young (35 year old) woman with severe second heart insufficiency. Upon transitioning from a standing to a sitting position, venous return is inadequate to maintain resting diastolic pressure above a hypotensive level. Specifically, following a transition from standing to quiet sitting, her diastolic pressure is seen to decline from about 80 mmHg, to less than 55 mmHg. Though sitting provides insufficient stimulation to the soleus muscles to maintain venous return, her soleus muscles remain capable of responding to external stimulation. Sustained soleus stimulation over 30 minutes returns her diastolic pressure back close to the normal range (~75 mmHg).
Soleus muscle retraining following three months of daily, external stimulation. Left panel - In a young adult (35 y.o.) woman, sitting provides insufficient soleus muscle stimulation to sustain the venous return necessary to prevent diastolic blood pressure from falling into a severe hypotensive range. However, external stimulation of the soleus muscles is able to return diastolic pressure back to the normal range. Right panel – Following three months of daily use of soleus muscle stimulation the soleus muscles are capable of preventing severe hypotension even over a sitting duration of 90 minutes, but still unable to sustain a normal diastolic pressure.
Three months of daily soleus muscle stimulation, for at least one hour per day, resulted in a substantially improved cardiovascular response to the orthostatic stress of quiet sitting in this subject (Figure 9 right panel). While sitting still resulted in a drop in diastolic blood pressure, the decline it seen to occur at a much slower rate, and to a lesser extent (falling to about 65 mmHg over 90 minutes). These results are consistent with fiber reconversion occurring within the soleus muscles. The differential response is consistent with an increase in the ability of the soleus muscle fibers regaining their fatigue resistance, and correspondingly, their ability to produce the sustained contractions required to ensure adequate venous return to the heart while seated.
The ability of soleus muscle stimulation to normalize cardiac output and blood pressure, raises the obvious question of the extent to which such improvements in cardiovascular function can influence cognitive function. Two small pilot studies we have undertaken lead us to believe there is substantial potential for this simple, non-invasive, intervention to slow, and even reverse, the cognitive decline associated with chronic exposure to low cardiac output and the corresponding low cerebral perfusion.
In a three month study on individuals (average age of 82 years) residing in an assisted living center [23], cognitive performance was tracked weekly using the Incongruent Stroop Executive Function Test [24]. Five control subjects with normal blood pressure (resting diastolic blood pressure above 70 mmHg) and five intervention subjects with below normal resting diastolic pressure were recruited into the study. Intervention subjects self-treated to one hour per day of soleus muscle stimulation using a HeartPartner soleus muscle passive exercise device (Sonostics, Inc.). While at the start of the study, the intervention group required almost twice as long to complete the executive function test. Over the three month duration of the study, blood pressures and test times for the control group remained steady. However, the intervention group experienced improvements in both their resting diastolic pressures and their ability to complete the Stroop executive function test, such that at the end of study, test execution times matched that of the control group (Figure 10).
Long term effects of daily soleus muscle stimulation on cognitive performance in an elderly (average age of 82) population residing in an assisted living center. Cognitive assessment relied on the incongruent Stroop executive function test. Control (normotensive) group test completion times did not vary significantly over three months. The intervention group (DBP < 70 mmHg at start of the study) received one hour per day of soleus muscle stimulation. While test completion times for the intervention group were initially almost twice that of the control group, over three months of daily soleus stimulation test times recovered to a level similar to that of the control group.
Because there is the potential for learning curve effects to play a role in traditional executive function tests such as the Incongruent Stroop when they are given repeatedly to the same study subjects over short separation times, we have also observed the influence of soleus muscle stimulation on cognitive function as assessed by a computer aided assessment which has been shown to have high repeatability and low learning curve effects, and which involves motor, memory, and executive function skills (Cognivue, Inc.). Six subjects, over the age of 65 years, who tested in the moderate to severe cognitive impairment range using the Cognivue assessment, were recruited. Each subject was provided with a soleus muscle stimulation device and encouraged to use the device for at least 2–3 hours per day. Subjects were tracked approximately every month, for six months, or until they cognitive performance returned to the normal range (Cognition score > 75).
All six subjects experienced a return to normal function during the course of the study, though the rate of return was dependent on age of the subjects (Figure 11). Subjects in their 60s demonstrated cognitive improvement rates of over 10%/week, while those in their 80s demonstrated improvement rates in the range of only 1–2% per week. Nonetheless, extrapolating over time, even these low rateswould mean that an older individual starting out with severe cognitive impairment (Cognition score < 50) would still be able to return to normal cognitive function within a one year period of time.
Cognitive recovery rates as a function of age. Subjects with cognitive performance in the moderate to severe cognitive performance range undertook soleus muscle stimulation for 2–3 hours per day until cognitive performance reached a normal level (cognition score > 75). Individuals in their 60s experienced cognitive performance improvement at a relatively remarkable rate of 10% per week. Individuals in their 8th or 9th decades experience cognitive improvement, but at much lower rates (1–2%/week). A 2%/week cognitive improvement rate indicates that approximately 6 months of intervention would be required to move an individual from the moderate cognitive impairment level to the normal cognitive function level.
The impact of dementia on both the healthcare system and society is already large and has the potential to become overwhelming in the near future. Alzheimer’s Disease is the most prevalent form of dementia and the strong association between beta-amyloid accumulation in the brain and Alzheimer’s provided some hope that if beta-amyloid production could be slowed, or its removal accelerated, dementia could be cured. To date, this strategy has failed to develop, and it is unclear if this strategy will be successful anytime in the near future.
As a result, the current consensus is that we need to identify a means of preventing the development of the cognitive aging which commonly progresses to dementia. Because this will require that any intervention will need to be implemented before there are indications of significant cognitive decline, successful interventions will have to be simple, inexpensive, non-invasive, and well accepted by older adults. Compliance is always challenging for healthcare interventions when the health condition is symptomless, and so it is always beneficial if the intervention produces benefits beyond the primary goal.
What has become clear over the past three decades is that reduced cardiac output, leading to reduced cerebral perfusion, is a robust predictor of cognitive aging and all cause dementia. Though cardiac output commonly declines with age, declining cardiac cardiovascular performance is not, per se, an age dependent outcome, but rather is a function of venous return. Venous return, correspondingly, is primarily dependent on the ability to maintain sufficient soleus muscle pump function whenever a person is in upright posture. The key, therefore, to maintaining cardiac output over a lifetime, is to maintain soleus function over an individual’s lifetime.
Soleus muscles lose their ability to maintain adequate venous return, in large part, due to modern society’s transition to chair sitting as the normal upright resting mode. Fortunately, like all muscles, the soleus muscles can be retrained and preliminary studies utilizing non-invasive soleus muscle stimulation technology has demonstrated that the improved cardiac output and normalization of blood pressure which results from soleus retraining leads to a reversal of cognitive decline even for those in their 9th decade of life. These preliminary results indicate that simple, well accepted, intervention techniques for the prevention, and even reversal, of cognitive aging, are a viable option for eliminating the devastating economic and social consequences of dementia.
The author would like to acknowledge the considerable assistance of Mr. Kyle Washington, and Ms. Linda Robertson, in the collection of data presented in this manuscript.
Dr. McLeod holds an equity position in Sonostics, Inc.
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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. His research interests include optimization, computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, and intelligent systems. Prof. Sarfraz has been a keynote/invited speaker at various platforms around the globe. He has advised/supervised more than 110 students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He has authored and/or edited around seventy books. Prof. Sarfraz is a member of various professional societies. He is a chair and member of international advisory committees and organizing committees of numerous international conferences. He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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This includes, but is not limited to: single-neuron modeling, sensory processing, motor control, memory, and synaptic plasticity, attention, identification, categorization, discrimination, learning, development, axonal patterning, guidance, neural architecture, behaviors, and dynamics of networks, cognition and the neuroscientific basis of consciousness. Particularly interesting are models of various types of more compound functions and abilities, various and more general fundamental principles (e.g., regarding architecture, organization, learning, development, etc.) found at various spatial and temporal levels.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",keywords:"Single-Neuron Modeling, Sensory Processing, Motor Control, Memory and Synaptic Pasticity, Attention, Identification, Categorization, Discrimination, Learning, Development, Axonal Patterning and Guidance, Neural Architecture, Behaviours and Dynamics of Networks, Cognition and the Neuroscientific Basis of Consciousness"},{id:"24",title:"Computer Vision",scope:"The scope of this topic is to disseminate the recent advances in the rapidly growing field of computer vision from both the theoretical and practical points of view. Novel computational algorithms for image analysis, scene understanding, biometrics, deep learning and their software or hardware implementations for natural and medical images, robotics, VR/AR, applications are some research directions relevant to this topic.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",keywords:"Image Analysis, Scene Understanding, Biometrics, Deep Learning, Software Implementation, Hardware Implementation, Natural Images, Medical Images, Robotics, VR/AR"},{id:"25",title:"Evolutionary Computation",scope:"Evolutionary computing is a paradigm that has grown dramatically in recent years. This group of bio-inspired metaheuristics solves multiple optimization problems by applying the metaphor of natural selection. It so far has solved problems such as resource allocation, routing, schedule planning, and engineering design. Moreover, in the field of machine learning, evolutionary computation has carved out a significant niche both in the generation of learning models and in the automatic design and optimization of hyperparameters in deep learning models. This collection aims to include quality volumes on various topics related to evolutionary algorithms and, alternatively, other metaheuristics of interest inspired by nature. For example, some of the issues of interest could be the following: Advances in evolutionary computation (Genetic algorithms, Genetic programming, Bio-inspired metaheuristics, Hybrid metaheuristics, Parallel ECs); Applications of evolutionary algorithms (Machine learning and Data Mining with EAs, Search-Based Software Engineering, Scheduling, and Planning Applications, Smart Transport Applications, Applications to Games, Image Analysis, Signal Processing and Pattern Recognition, Applications to Sustainability).",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",keywords:"Genetic Algorithms, Genetic Programming, Evolutionary Programming, Evolution Strategies, Hybrid Algorithms, Bioinspired Metaheuristics, Ant Colony Optimization, Evolutionary Learning, Hyperparameter Optimization"},{id:"26",title:"Machine Learning and Data Mining",scope:"The scope of machine learning and data mining is immense and is growing every day. It has become a massive part of our daily lives, making predictions based on experience, making this a fascinating area that solves problems that otherwise would not be possible or easy to solve. This topic aims to encompass algorithms that learn from experience (supervised and unsupervised), improve their performance over time and enable machines to make data-driven decisions. It is not limited to any particular applications, but contributions are encouraged from all disciplines.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",keywords:"Intelligent Systems, Machine Learning, Data Science, Data Mining, Artificial Intelligence"},{id:"27",title:"Multi-Agent Systems",scope:"Multi-agent systems are recognised as a state of the art field in Artificial Intelligence studies, which is popular due to the usefulness in facilitation capabilities to handle real-world problem-solving in a distributed fashion. The area covers many techniques that offer solutions to emerging problems in robotics and enterprise-level software systems. Collaborative intelligence is highly and effectively achieved with multi-agent systems. Areas of application include swarms of robots, flocks of UAVs, collaborative software management. Given the level of technological enhancements, the popularity of machine learning in use has opened a new chapter in multi-agent studies alongside the practical challenges and long-lasting collaboration issues in the field. It has increased the urgency and the need for further studies in this field. We welcome chapters presenting research on the many applications of multi-agent studies including, but not limited to, the following key areas: machine learning for multi-agent systems; modeling swarms robots and flocks of UAVs with multi-agent systems; decision science and multi-agent systems; software engineering for and with multi-agent systems; tools and technologies of multi-agent systems.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",keywords:"Collaborative Intelligence, Learning, Distributed Control System, Swarm Robotics, Decision Science, Software Engineering"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"25",title:"Environmental Sciences",doi:"10.5772/intechopen.100362",issn:"2754-6713",scope:"\r\n\tScientists have long researched to understand the environment and man’s place in it. The search for this knowledge grows in importance as rapid increases in population and economic development intensify humans’ stresses on ecosystems. Fortunately, rapid increases in multiple scientific areas are advancing our understanding of environmental sciences. Breakthroughs in computing, molecular biology, ecology, and sustainability science are enhancing our ability to utilize environmental sciences to address real-world problems.
\r\n\tThe four topics of this book series - Pollution; Environmental Resilience and Management; Ecosystems and Biodiversity; and Water Science - will address important areas of advancement in the environmental sciences. They will represent an excellent initial grouping of published works on these critical topics.
\r\n\tPollution is caused by a wide variety of human activities and occurs in diverse forms, for example biological, chemical, et cetera. In recent years, significant efforts have been made to ensure that the environment is clean, that rigorous rules are implemented, and old laws are updated to reduce the risks towards humans and ecosystems. However, rapid industrialization and the need for more cultivable sources or habitable lands, for an increasing population, as well as fewer alternatives for waste disposal, make the pollution control tasks more challenging. Therefore, this topic will focus on assessing and managing environmental pollution. It will cover various subjects, including risk assessment due to the pollution of ecosystems, transport and fate of pollutants, restoration or remediation of polluted matrices, and efforts towards sustainable solutions to minimize environmental pollution.
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",annualVolume:11967,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/39.jpg",editor:{id:"137040",title:"Prof.",name:"Jose",middleName:null,surname:"Navarro-Pedreño",fullName:"Jose Navarro-Pedreño",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRAXrQAO/Profile_Picture_2022-03-09T15:50:19.jpg",institutionString:"Miguel Hernández University of Elche, Spain",institution:null},editorTwo:null,editorThree:null,editorialBoard:[{id:"177015",title:"Prof.",name:"Elke Jurandy",middleName:null,surname:"Bran Nogueira Cardoso",fullName:"Elke Jurandy Bran Nogueira Cardoso",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRGxzQAG/Profile_Picture_2022-03-25T08:32:33.jpg",institutionString:"Universidade de São Paulo, Brazil",institution:null},{id:"211260",title:"Dr.",name:"Sandra",middleName:null,surname:"Ricart",fullName:"Sandra Ricart",profilePictureURL:"https://mts.intechopen.com/storage/users/211260/images/system/211260.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}}]},{id:"40",title:"Ecosystems and Biodiversity",keywords:"Ecosystems, Biodiversity, Fauna, Taxonomy, Invasive species, Destruction of habitats, Overexploitation of natural resources, Pollution, Global warming, Conservation of natural spaces, Bioremediation",scope:"