HPM60 temperature and relative humidity sensor specification.
\r\n\tThe purpose of this book is to provide the readers with an understanding of the characteristics of the crisis itself, recognize the wide range and multi-layer of the crisis from a real situation, give ideas on how to minimize the damage, and find ways to increase resilience in the future. To adapt to the rapidly and diversely changing world, the necessary experience and appropriate management for all kinds of crisis issues will be discussed as well. At the same time, it is intended to suggest elements such as verified scientific and empirical knowledge and applicable technologies; more effective risk management operation; modeling of the risks, manuals, management plans, and strategies.
\r\n\t
Analysing the statistics of earthquakes can contribute to a better understanding of such processes, for example, the Omori law for the decay of aftershock activity [1] and the law of Gutenberg-Richter as measure for the relationship between the frequency and magnitude of earthquakes [2]. These approaches and others allow for assessing the spatial distribution of stress on a seismic fault or estimating seismic risk following earthquakes of great magnitude [3]. It is important to study the three quantities that characterize a seismic process, i.e., magnitude, space and time, as opposed to only studying magnitudes. The interevent intervals, i.e., intervals between consecutive earthquakes in a region, have been extensively studied using a range of different approaches [4, 5]. Furthermore, statistics pertaining to the distances between consecutive events (or jumps) is equally important for the analysis of risks, but has been much less studied [6].
Recent studies have shown that many complex natural systems are characterized by correlations [7]; however, the identification and quantification of the presence of these long range correlations using spectral analysis is inadequate, because the data are non-stationary. However, the detrended fluctuation method DFA enables the detection of correlations in non-stationary time series, thereby avoiding spurious detections [8, 9]. Telesca et al. [10] described the scale behaviour of seismic sequences in Southern California from 1981 to 1998 (Figure 1), represented as a two-dimensional sequence of jumps and interevent intervals. They used the catalogue of Richards-Dinger and Shearer (RDS) [11], which in the years mentioned above lists 284925 events. The catalogue is complete from a magnitude of
The results of the work by Telesca et al. are in some ways surprising, because in general, such correlations were not expected; eventually, it was revealed that the recurrence time series (or interevent intervals) and the series of jumps (distances between epicentres) show long-term correlations. The objectives of the current paper are to reproduce and supplement the results of Telesca et al. with an extended catalogue of seismicity occurring in California, then to compare this results with a time series of synthetic earthquakes obtained using a model, and finally, to look for patterns in the method in order to calculate the fractal dimensions of Higuchi, which can be used as seismic precursors.
The zone considered in the study by Telesca et al. and in the present work.
First, it the results of Telesca et al. were checked and validated. It was then checked whether these results would still be valid if an expanded catalogue of the Southern California seismicity was used, but updating the data to 2014. The types of correlations that the time series of earthquakes had in terms of magnitude was then investigated, which Telesca et al. did not complete.
There are many registered events, but only events with a magnitude greater or equal to 1.5 were considered, because the catalogue was complete for these magnitudes.
The DFA method proposed in 1993 by Peng et al. [7, 9] begins with a series of length
This is done on various timescales (box sizes) to check if there is power law behaviour between
A catalogue of seismicity was used as a time series; when the DFA method is applied to a time series, it is possible that crossovers can be obtained, i.e., the graph has two or more linear regions, each one with a different slope; therefore, two or more DFA exponents are needed to describe the dynamics of correlations. In the present case, Telesca et al. found crossovers in the graphics of the DFA method, but they only considered the last part of the graphics, i.e., only the large-sized boxes. In order for the results to be consistent, in this part, the adjustment was also effected in the final part of the graph to obtain the correlation exponent, as shown in Figure 4.
The time series with magnitudes greater than or equal to a threshold clearly shows fewer events.
An important aspect is the elimination of the trend; this is usually done by adjusting the graph of
The procedure to build the series was as follows: first, the (RDS) catalogue was obtained [11].This catalogue is freely available; however, for some reason, the website from which it is discharged and six months of data were missing. It was therefore necessary to complete the catalogue. This work was also conducted by Telesca et al. [9], but they do not mention it in their article; instead, they simply state that the catalogue is complete for magnitudes of 1.5 and higher. However, without the missing data of those six months this statement is not true; therefore, the data were completed using the catalogue and its associated data from the Southern California Seismic Network (SCSN). Missing data were obtained to complete the RDS catalogue and data were also obtained to expand the base up to the present. The extended catalogue was also completed for seismic events greater than or equal to a magnitude of 1.5, as was the previous catalogue. It is useful to work with a catalogue that is complete from a magnitude perspective, so that small the statistical results will be more significant, given that there are many events in the catalogue. For the same period, Mexican catalogues contain little statistics from a magnitude of 4.0; as a result, statistical analyses concerning this data must be conducted in a different way.
Graphic of the DFA method for a seismic series. In this part of the work, the least square adjustment was carried out on the latest data from the graph. As this figure shows, this was done with the purpose of avoiding a crossover effect, in which case it would have been necessary to use two correlation exponents, one before the crossover and one after it. This approach was used because one of the objectives of the present research was to compare the results with those reported by Telesca et al. [
Once the catalogue was extended, a time series of magnitudes, recurrence times and distance between the epicentres for different thresholds were constructed. The thresholds that were used were almost the same as those of Telesca et al., i.e., from 1.5 to 4.0 at intervals of 0.1 and the maximum magnitude of threshold was increased because there were more events.
The subseries had less data as the threshold increased and the magnitude series was easier-to-build. Once the magnitude time series for each threshold had been built, as the occurrence times of each earthquake became known, the differences between them were considered the elapsed times between each event. As the threshold was increased, the recurrence times became larger, because it required an extended period of time to produce an earthquake of the same magnitude or greater. To obtain the series of distances between epicentres, the following procedure was used: the angular distance between two events was calculated using the following formula [14],
where (
The first aspect that should be highlighted is that the results of Telesca et al. were reproduced for the data of the RDS catalogue, i.e., for a recurrence times series and a series of distances between epicentres. The correlations are 1/f for small thresholds and these become lower as the threshold is increased. Results for the expanded catalogue can be summarized in Figures 5, 6 and 7. The first shows the correlation in terms of the threshold for recurrence times. As can be seen, such a series shows long term correlations or 1/f noise for small thresholds, which will reduce as the threshold is increased. For larger thresholds, it is much closer to white noise (absence of correlations) than to 1/f noise. Figure 6 shows the magnitude series; however, for small thresholds of 1/f noise, this was not maintained, as is the case with the recurrence time series. Though the DFA exponents quickly began to decrease, they nonetheless had the same correlation values for high thresholds as the recurrence time series.
Graphic of the correlation exponents as the threshold is increased for the series of recurrence times. Almost up to a threshold of magnitude 3.0 the 1/f behaviour type remains constant and then begins to decrease close to being white noise. The DFA exponent had no units.
Graph of the correlation exponents obtained with the DFA method for the series of magnitudes; however, the dynamic was different for these series than for times of recurrence and distances between epicentres; 1/f behaviour was also present for low thresholds and there was white noise for high thresholds; however, 1/f noise was not maintained to the threshold of 3.0, but decreased immediately, showing almost linear behaviour.
Finally, Figure 7 shows the results for the series of distances between epicentres. The dynamics of correlations are practically the same as that for the recurrence time series, i.e., noise 1/f for small thresholds, which is kept up to almost a threshold of 3.0 and then begins to decrease until it approaches white noise.
Graphic of the correlation exponents as the threshold is increased for the series of distance between epicentres. Almost up to a threshold of magnitude 3.0 it remains as 1/f behaviour, then begins to decrease until it approaches white noise. The dynamic is practically the same as for recurrence times.
Since the graphs for calculating the correlation exponents present a crossover, in this part of the work, an integral analysis of such graphs was carried out, which included the calculation of correlation exponents before and after the crossover, as well as the analysis of the behaviour of the crossing points before and after events of greater magnitude. Crossovers divide the graph into two regions, each of which can be adjusted with a straight line; values of the slope before the crossover (high frequencies) are lower than the values of the slope after the crossover (low frequencies) (see Figure 8).
Figure 9 shows the correlation exponents as the threshold is increased for the recurrence time series, distance between epicentres and magnitudes. As can be seen, following the crossover, as previously mentioned, the correlations of the recurrence time series and the distance between epicentres series showed 1/f behaviour up to a threshold of 3.0, then began to drop to almost white noise. Correlations after the crossover of magnitude series also began as 1/f noise and they decreased more quickly than in the previous cases. The three graphics in the lower part are the DFA exponents before the crossover, first they were very close to white noise and then their values grow to the same values that the graphs after the crossover. The fact that they crossed means that there was no crossover for large thresholds.
The DFA method showing the crossover and the two regions for high and low frequencies.
Correlation exponents before and after the crossover. The upper plots are the recurrence time, distance between epicentres and magnitude series after the crossover. The lower plots are the same but prior to the crossover; at the end, they cross and as such, for large thresholds there were no crossovers.
Figures 10 and 11 amplify the results for the DFA before and after the crossover. Red dots correspond to the times of recurrence series, blue dots correspond to the series of distances between epicentres and the black dots correspond to the series of magnitudes. Before the crossover, the correlations are not important (it is essentially white noise), when the threshold is increased the series are long-term correlated, with the exception of the magnitude series, which DFA exponents are close to white noise. After the crossover, series of magnitudes for low thresholds were 1/f noise and decreased essentially in a linear fashion. The correlations of the series in terms of recurrence and distance between epicentre times also decreased, but not as quickly as the magnitude series.
The position of the crossover is shown in Figure 12; behaviour for the three types of time series were the same and the crossover moved to the left as the threshold increased.
Correlation exponents before the crossover for the time series of recurrence times (red), distance between epicentres (blue) and magnitude (black).
Correlation exponents after the crossover for the time series of recurrence times (red), distance between epicentres (blue) and magnitude (black).
Position of the crossover.
The following section explores the results of Telesca et al. by using a synthetic seismicity model, i.e., the model created by Olami, Feder and Christensen (OFC), which has qualitatively reproduced many of the properties of synthetic seismicity.
In 1997, Bak et al. [15, 16] introduced the new concept of self-organized criticality (SOC). This concept was introduced as a principle for describing the behaviour of complex dynamic systems. Bak et al. affirmed that these open systems, with many elements that have nonlinear interactions, organize themselves into a state that is critical and stationary. Spatial and temporal power laws characterize this critical state. When a system reaches this state, any event can begin a chain reaction or “avalanche” that can produce a catastrophe. The presence of 1/f noise is the temporal “finger print” of the SOC state and the appearance of a fractal structure is the spatial signature. Fractal behaviour is a frequent property of many geological phenomena and structures, and is reflected in empirical power laws [17]. The earth’s crust can be seen as a hierarchical set of shapes and sizes suitable for a fractal description. The so-called Gutenberg-Richter (GR) law for the size distribution of earthquakes is a typical power law of seismology [2]. Bak has asserted [18] that any numerical or theoretical model based on the SOC concept must reproduce the Gutenberg-Richter law as proof of its consistency.
Many authors [19-27] have reported SOC-versions of the Burridge-Knopoff (BK) spring-block model [28] for earthquakes. This model mimics the behaviour of a seismic fault by using a linear spring-block array, the dynamics of which are obtained by solving the system of differential equations that describes it. The subsequent BK-type models were solved using cellular automata. These models have been solved in two- and three dimensions, and have been very successful in the qualitative reproduction of the GR law, as well as several other properties of real seismicity [24- 25, 29-32]. These results have strengthened the notion that earth’s crust is a SOC-system.
The OFC earthquake model is a version of the spring block BK model in two dimensions. This model was the first attempt at obtaining self-organized criticality in a non-conservative model. The model has many blocks located on a rectangular plate (Figure 13). Each block in this array is joined to its four block neighbours by harmonic springs and all of them are lugged by other springs fastened to a superior plate, which is moved at a very low and constant speed. The upper plate is moved and causes the stress (or force) to increase in each block until the force equals a previously established threshold (the stress for the fault breaking), and then the block slips into a residual force state. Each sliding block transfers stress to its neighbours and when these neighbours reach the threshold, they also slip and so on. In this way, a chain reaction or synthetic earthquake can be generated that will not stop until all the stress values in the blocks are less than the threshold.
Spring block model geometry. The relative movement of the two plates increases the stress on the blocks.
As noted, in this model, each block has four nearest neighbours and is connected to them. According to Olami et al. [21-22], once a block relaxes, the force in it is set equal to zero. In the present study, the arrangement was a square of
where
where the force increment in the nearest neighbours is given by,
Olami et al. used open frontier conditions and reports robust SOC behaviour for earthquake sizes probability distribution. They found a power law in qualitative agreement with the GR law and discovered that the earthquake frequency was related to the magnitude
where
For studying the results of the OFC model in relation to the results of Telesca et al., the procedure was as follows: for different values of the conservation level α and the size of the network that represented the failure of 100 x 100, i.e., 10,000 blocks, synthetic seismicity catalogue were obtained, each with 1x106 events. In each of the synthetic earthquakes the number of blocks that were relaxed was counted; this number of blocks can be associated with magnitude value: when only a few blocks relax, the earthquake will have a small magnitude; when many blocks relax, there will be a synthetic earthquake of great magnitude. For example, Figure 14 shows one synthetic earthquake; each of the circles represents one of the relaxed blocks and the magnitude of the synthetic earthquake is the number of all the blocks that were relaxed. The epicentre is denoted by a small x; in this case, it is the block in which the earthquake started. As can be seen, it is very easy to obtain the coordinates of such epicentres.
A synthetic earthquake that occurred in a region of the network representing the seismic fault. In this case, the network size was 100 x 100 and the level of conservation was α = 0.24. The site where the earthquake began, i.e., the epicentre, is indicated by X.
The synthetic seismicity catalogue contains the magnitude, the coordinates of the epicentre and the time of occurrence for each of the synthetic earthquakes. Figure 15 shows a section of one of these catalogues, where magnitude is represented by the number of blocks that were relaxed in each event.
The magnitude M was defined as
A section of one of the synthetic seismicity catalogues. In this case, the synthetic earthquakes were generated in a network of size 100 x 100 with a conservation level of α = 0.2. Magnitude in this case was the number of blocks that were relaxed.
Once a threshold had been selected, the number of earthquakes was reduced; for example, if a threshold value of 100 was chosen, only earthquakes in which 100 or more blocks were relaxed remained. The magnitude series can be easily determined, because it is formed by the magnitude of the earthquakes that remain. Since each earthquake\'s epicentre coordinates are known, the distance between the epicentres can be determined and therefore also the corresponding series of jumps or distances between epicentres. The time between each of the events can also be determined, i.e., the recurrence times. For example, Figure 16 shows the epicentres of earthquakes left behind when a threshold of 243 is applied as log3(243) = 5; this means that these earthquakes have a magnitude greater than or equal to 5.0. As each of the events is perfectly identified, the distance between epicentres and recurrence times are easy to determine. For example, Figure 17 shows a series of recurrence times when the threshold was placed at 3; as can be seen, from the initial 1000 000 synthetic earthquakes only approximately 300 0000 remain. Figure 18 shows a series of jumps where the threshold is set to 729; the results show that just over 4000 events has a magnitude greater than or equal to 6.0.
For each level of conservation that was used (0.2, 0.21, 0.23 and 0.22 0.24) one million events were obtained. Following on, a subseries for each one of the thresholds was obtained for each catalogue. The thresholds that were used were 2.0 to 7.0 at intervals of 0.1; then, the procedure that Telesca et al. applied to the seismicity of the south of California was repeated, i.e., the DFA method was applied to the series of magnitudes, recurrence times and distances between epicentres with the goal of calculating the type of existing correlations. Considering that this model has replicated properties of real seismicity in a qualitative way, it was hypothesized that the results would be very similar to those obtained in real seismicity.
For the sake of brevity, the results are shown only for a value of the conservation level, as the results for other conservation levels were virtually the same. Figure 19 shows the correlations for different thresholds of the three types of series considered. The study of the time series of synthetic earthquakes obtained from the OFC model allowed for reproducing the results observed for real seismicity by Telesca et al. with regards to the series of recurrence times. For low thresholds, there were long-range correlations (1/f) and these correlations decreased for larger thresholds. For the series of magnitudes and for the series of jumps, the results did not coincide; for low thresholds, the series showed an absence of correlations and there were important correlations only for large thresholds. These results are not disappointing, although they are somewhat contradictory, as it was not expected that a model as simple as the OFC would be able to reproduce all the properties of the correlations that were found in the case of real seismicity.
Coordinates of the epicentres remaining when the threshold was 243, i.e., earthquakes that had magnitudes greater than or equal to 5.0. As the model mimics a flat failure, the distance between epicentres was calculated in the same way as the distance between two points in geometry. The coordinates were not real and thus, there were no units.
The remaining earthquakes when the threshold was set equal to 3.0. This meant that all the eliminated earthquakes had magnitudes less than 1.0. In this case, recurrence times are shown, that is, the elapsed time between each of the events. The interevent interval was a number of steps in the program and therefore did not have physical units.
Series of jumps or distance between epicentres when the threshold was 729, i.e., only earthquakes with magnitudes greater than or equal to 6.0 remained. As the grid dimension was 100 x 100, the minimum distance was 1.0, while the maximum distance would have been at about 140.
DFA exponent for the time series of recurrence times (triangles), magnitude (circles) and jumps or distances between the epicentres of consecutive events (points), with a level of conservation of 0.24, n = 100.
Complex systems such as seismic zones generate time series showing the combination of fractal and periodic components. Two decades ago, the so-called Higuchi`s method [12, 13] for calculating the fractal dimension of complex time series has been applied to investigate correlations and non-linear dynamic properties embedded in non-stationary time series. For example, this method has been used for analysing electroseismic time series [33]. Recently, Higuchi’s method has been used to detect periodic components mixed with fractal signals [34-36].
In this part of the work, the seismicity of Southern California is studied using Higuchi\'s fractal dimension method. The idea is to apply the method of windowing to Higuchi’s method to study whether there is a pattern that can be identified as a possible precursor to events of great magnitude. Here, the results of the windowing are presented, which suggest that some months prior to an earthquake, there is little variation in Higuchi’s fractal dimension, while closer to the main event this pattern changes and the fractal dimension decreases.
A time series can be expressed by
From the time series
where
The length of the series
The term
The length of the series
If
Evaluation of the fractal dimension of Brownian noise using Higuchi’s method. In this case, the slope is approximately 1.5 and
In the case of self-affine curves, this fractal dimension relates to the exponent
The catalogue containing data compiled by the Southern California Seismic Network (SCSN) was used for the calculation of the Higuchi’s dimension. The catalogue contains all data since 1981 and up to 2014 (between 32o and 37o north latitude and 114o and 122o west longitude) and events of a magnitude less than 1.5 were not considered in the analysis; however, there were still thousands of events left with which to make calculations. When applying Higuchi’s method, long-range correlations are always found, because the obtained
For each of the three above-mentioned earthquakes, a period of six years was analysed, three years prior to the earthquake and three years following it. If one of the three earthquakes was j-th, the windows were moved forward and backward. Each window had 1000 data. For example, the first window to the right contained data from the
As already noted, Higuchi´s method was not applied directly to the time series. The three events with the highest magnitude in the catalogue were selected; these were events with magnitudes greater than 7.0. The first had a magnitude of 7.2 and occurred on 28 June, 1992; the second had a magnitude of 7.1 and occurred on 16 October, 1999; the third, the epicentre of which was located on the Mexican side, had a magnitude of 7.2 and occurred on 4 April, 2010. These three events were removed from the catalogue and then, subsets of the catalogue with a duration of six years were chosen and Higuchi’ method was applied to them. However, when measuring windows (hence the term \'Higuchi’s windowing\'), it was found that the windows overlapped in order to contain an adequate number of data. Higuchi´s dimension and the y-intercept were calculated prior to and following the earthquake for each window and the graphs obtained are shown below. For each earthquake, three figures are shown: the first indicates the location of the earthquake in the catalogue during periods of six years (except for the last, which had almost five years), the second shows the variation of the fractal dimension in the windows before and after the earthquake and the third shows the y-intercept for each window before and after the earthquake. In general, it was observed that for the three events, there was a variation of the fractal dimension
The earthquake of magnitude 7.3 on 28 June, 1992; the graphic shows six years of events higher or equal to 1.5, three years before and three years after the earthquake.
Higuchi’s windowing, implemented over a period of six years around the event on 28 June 1992. EQ indicates when the aforementioned earthquake occurred. Note that there is significant variation in Higuchi’s fractal dimension and a decrease therein prior to the earthquake.
The
The earthquake of magnitude 7.1 on 16 October, 1999. The graphic shows six years of events higher than or equal to 1.5, three years before and three years after the earthquake.
Higuchi’s windowing method, implemented over a period of six years around the event on 16 October, 1999. Qualitatively, similar behaviour was observed to the 1992 event shown in
The
The earthquake of magnitude 7.2 on 4 April, 2010. The graphic shows almost five years of events higher than or equal to 1.5, three years before and after the earthquake.
Higuchi’s windowing method, implemented over a period of almost five years around the event on 4 April, 2010. Note again the decrease in the fractal dimension prior to the earthquake.
Note how it is once again clear that the earthquake occurred after the rise in the values of the
Analysis of seismic series obtained for Southern California during the period of 1981 to 2014 showed that the results by Telesca et al. could be reproduced in this expanded catalogue, i.e., for the recurrence times series and for the distance between epicentres series. Behaviour with long-range correlations for low thresholds was obtained and was maintained for intermediate thresholds; for high thresholds, behaviour close to white noise was obtained. In contrast, in the series of magnitude, although there was a decrease in correlations, the behaviour type 1/f noise was not maintained; the correlations immediately began to decrease, almost linearly approaching values also obtained for other series and for high thresholds, i.e., closer to white noise. Verifying these results was attempted using synthetic seismicity catalogues obtained from the spring-block model of Olami, Feder and Christensen.
Interesting results were found that showed anomalous behaviour in the fractal dimension, possibly indicating the imminence of an earthquake of great magnitude. These results were found using Higuchi’s windowing method and by calculating the fractal dimension and the value y-intercept in each window. A decreasing pattern was observed in the fractal dimension prior to three earthquakes with magnitudes greater than 7.0. Additionally, an increase in the value of the
The author acknowledges EDI, SIP and COFFA-IPN for partial support.
Over the years, building design, occupants’ behaviour, choice of technology usage, and manufacturing and construction processes have resulted in the increasing energy consumption as well as the release of greenhouse gases (GHG) in the building sector [1]. Globally the building sector consumes over 30% of total final energy, having increased by more than 35% since 1990 and, at the same time, accounting for 30% of CO2 gas emission. The building sector also accounts for half of the world electricity demand, with some region electricity consumption increased by 500% [2]. In the residential sector, energy is consumed for space heating, cooling, domestic activities, and lighting, among others.
\nHowever, the use of improved thermal building envelope, bioclimatic design, and energy-efficient appliance, as well as light fittings, has seen the offset of energy demand from floor and population growth in the building sector [3]. Thus, final energy demand in the building sector only rose by 5% between 2010 and 2017. Within the above specified period, a significant decline in space heating was observed, while improvement in space heating is not visible [4].
\nIn South Africa, the housing shortage in most rural communities resulted in the mass construction of houses (low-cost) in the Reconstruction Development Program (RDP) in 1994. Since the inception of low-cost housing (LCH), more than 4.9 million households have been accommodated with over 2.3 million backlogs [5, 6]. According to Klunne, LCH are designed with no consideration of thermal energy efficiency, as they cannot utilise solar energy for space heating. He further indicated that uncontrollable heat exchange between the inner and outer space of the house due to openings and cracks on the building envelope leaves the inner space extremely cold in winter [7]. In 2005, Overy also found that the quality of LCH is poor with 90% of newly built houses not conforming to the national norms and standards. In his report, he also eluded that corruption and the use of unqualified contractors (builders) are at the forefront of the nature of the houses [8]. However, LCH dwellers tend to bear the burden as they spend a significant amount of their income to achieve thermal comfort indoors [9]. Most households that cannot afford electrical energy resort to the use of firewood, coal, paraffin heaters, or thick clothing as alternative sources of energy for heating. This results in poor indoor air quality, cold-related illness, early child motility, respiratory diseases, etc. [10, 11]. Needless to say, the provision of LCH is a positive approach to rural development in the country, but incorporating passive solar design will improve the welfare of occupants and energy consumed in space heating as well as cooling, creating sustainable rural development.
\nThe ambient weather of a house possesses a significant amount of energy required to naturally heat or cool the inner space at little or no expense. At the same time, the uncomfortable thermal condition indoors is due to the uncontrollable interaction between the indoor and ambient weather factors [12]. Hence, to efficiently utilise the ambient weather energy indoors, a selective thermal exchange between the inner and outer environment is required; this process is known as passive solar or bioclimatic design [13]. A passive solar design uses heat movement such as conduction, convection, and radiation to admit and distribute heat in the inner space of a house.
\nOn a typical sunny day, heat is transmitted through the windows due to radiation and conduction. The transmitted heat is stored and distributed by furniture and indoor air due to conduction and convection, respectively. Minimum infiltration air heat transfer through enhanced airtightness and controlled ventilation components are among the strategies of passive solar design. Conductive heat transfer through the perimeter walls of a passive solar house is also avoided as it is uncontrollable [14]. Regarding cooling, strategic locating and sizing of windows are used to achieve various airflow indoors. Windows at the windward and leeward side of the house create pressure difference indoors, resulting in a cross-ventilation [15, 16]. Also, locating windows or vents at significant height results in another form of airflow known as stack effect. Stack effect occurs due to vertical air temperature variation indoor. Therefore, the rate of airflow increases with an increase in the height between the upper and lower windows or vents [17].
\nIn both aspects of passive solar design mentioned above, the windows play a vital role, considering the building envelope components, whereas the sun and wind constitute the ambient weather influencing factors. The windows in a passive solar house are strategically located and sized to take advantage of the ambient climate condition effectively. A prototype rural LCH energy-efficient house was design and constructed in SolarWatt Park based on the principle of a passive solar house. The aim of this study is to analyse the thermal performance of the house. In the context of this study, the thermal performance of the house is analysed based on the indoor weather condition relative to the outdoor ambient weather and the windows.
\nSolarWatt Park is located at the University of Fort Hare, Alice, in the Eastern Cape, South Africa. Alice is classified in the temperate interior (zone 2) climate of South Africa [18]. Typical annual season of Alice is characterised by a hot summer and mild (no snow) winter, with an average dry bulb temperature of 29 and 15°C, respectively. The east wind is predominant in summer, while the winter is dominated by the west wind. An average wind speed of 2.5 m/s is experienced in Alice throughout the year [19]. A climatic map of South Africa [20], the Google earth map of SolarWatt Park and the passive solar house are presented in Figure 1.
\nClimatic map of South Africa indicating the location of the SolarWatt Park and a photo of the passive solar house.
The site was found suitable for the design and construction of the passive solar house due to its clear north side with no sunrays’ obstacle such as tall trees, mountains and high-rise buildings. Therefore, the house was designed with its major glazing area facing north which is by the energy-efficient building design recommendation in South Africa [18, 20]. A simulated daily sun path of the house with respect to its orientation is shown in Figure 2.
\nA 3D view sun path simulation of the house.
In the northern hemisphere, north-orientated housing design guarantees optimum sunray penetration in the winter season due to the low-angle sun. The penetrated sunrays, therefore, provide heating and daylighting indoors. However, the 44-cm long eaves are used to prevent overheating indoors during the summer season by blocking direct sunrays. To this effect, the two large north-facing windows (see Figure 2) distribute solar radiation to the northern floor area of the house, while the clerestory windows channel solar radiance to the southern floor area. Hence, even solar radiation distribution is achieved indoors.
\nMeanwhile, the clerestory windows enhance indoor passive cooling due to convectional current and various wind effects through effective operations of the windows [16].
\nFurthermore, the house is made up of 10 m × 8 m (80 m2) floor area and consists of a bathroom, an open plan living room/kitchen and two north- and south-facing bedrooms. The floor area was arranged to ensure optimum and uniform distribution of solar radiation. The floor plan of the house indicating the floor arrangement is shown in Figure 3.
\nThe floor layout of the passive solar house indicating the floor arrangement and various zone 1.
The floor plan was virtually partitioned into three thermal zones. Zone 1 marked with blue diagonal cross-hatch lines filled region is the living room/kitchen. The red diagonal up lines filled region used to indicate the north-facing bedroom is zone 2, while the south-facing bedroom is zone 3, represented by the region filled with green vertical lines. The bathroom was not shaded since it is not considered as a thermal zone.
\nIn 2009, the construction of the passive solar house was estimated to be $36, 579.55 with 1.00 USD equivalent to 11.76 ZAR, while its counterpart cost is $8505.62 [21]. In spite of the cost margin, passive solar house presents a decent home compared to conventional low-cost house [9, 16, 22].
\nThe indoor and outdoor thermal condition measurement deals with the air temperature and relative humidity in both environments. Therefore, HMP60 temperature and relative humidity probe were used to measure the indoor as well as the outdoor air temperature and relative humidity of all zones in the house. The HMP60 probe uses a platinum resistance temperature (PRT) detector to measure air temperature, while air relative humidity is measured by capacitive relative humidity sensor [23, 24]. The measurement specifications of HMP60 probe temperature and relative humidity sensor are given in Table 1 [25].
\nParameters | \nMeasurement range | \nAccuracy (±) | \n|
---|---|---|---|
Temperature (°C) | \n−40 to +60 | \n0.6 | \n|
Relative humidity (%) | \nAt 0–40°C | \n0–90 | \n3 | \n
90–100 | \n5 | \n||
At 0–40°C and +40°C to +60°C | \n0–90 | \n5 | \n|
90–100 | \n7 | \n
HPM60 temperature and relative humidity sensor specification.
Three sets of HMP60 probes were used to measure the indoor air temperature and relative humidity. In each zone, one HMP60 probe was suspended at the height of 0.8 m to ensure that the measured air temperature is nearest to the temperature felt by the occupants. At the same time, the probe does not obstruct the activities of the occupants. The locations of the HMP60 probe in the house and a set outdoor weather station are indicated in Figure 4.
\n(a) Floor layout of the house indicating the location of the indoor thermal sensor and (b) setup outdoor weather station.
As shown in Figure 4(b), the outdoor air temperature and relative humidity measuring probe was housed in a 6-plate naturally aspirated radiation shield. The white painted radiation shield enables it to reflect solar radiation. At the same time, the louvre allows natural free flow of air through the shield, thereby keeping the probe as close as possible to the ambient air temperature (eliminating solar effect) and water vapour [26].
\nIn this study, solar radiation measurements cover ambient global horizontal irradiance (GHI) and global irradiance at the four perimeter walls of the house. Due to atmospheric interference, the sum of direct and diffuse solar radiation reaching the earth surface, excluding albedo, is called global radiation, and it can be observed on vertical and horizontal surfaces. Thus measured global radiation on a horizontal plane is called global horizontal irradiance [27, 28].
\nAt the right-hand side of the outdoor weather monitoring setup in Figure 4(b), the horizontally levelled Kipp and Zonen CMP-11 pyranometer was used to monitor the global horizontal irradiance (GHI). The pyranometer uses a 32-junction thermopile to measure solar radiation with a sensitivity of 8 μV m−2 and a spectral range of 285–2800 nm. Its response time is less than 1.7 s (63%) and 5 s (95%) [29]. The outdoor weather setup was elevated by 1 m above the roof, to ensure an unobstructed space for the radiometer. The pyranometer’s dome was also cleaned twice per week to keep the dome clear of dew, dust, frost, birds’ excreta, and any substance that may obstruct transmission of solar radiation.
\nDue to the daily sun movement, the solar irradiance at the elevations of a house varies. This, however, influences the thermal impact of the windows at various elevations. Thus, four Li-Cor 200R pyranometers with one pyranometer at each of the house elevation were used to monitor the global irradiance at the various elevations. Figure 5 shows a Li-Cor 200R pyranometer measuring the global irradiance in one of the house’s elevations.
\nLi-Cor 200R pyranometer for monitoring global vertical irradiance on the east elevation of the passive solar house.
As illustrated in Figure 5, the pyranometers were mounted vertically on the outer surface of each of the perimeter wall. They were mounted at an even height of 1.8 m. By so doing, the solar radiation falling on the walls was measured. Li-Cor pyranometer uses a silicon photovoltaic sensor mounted in a cosine-corrected head to measure solar irradiance. Together, a variable shunt resistor circuit in the cable is used to convert the measured current to a voltage signal [30].
\nThermal monitoring of the house which involves the global horizontal irradiance (GHI), resultant global irradiance at the various elevations, and indoor and ambient air temperature was initiated in September 2016 and continued until September 2017. Uncontrollably, 944 data entries were missed, amounting to 5% of missing data. The missing data occurs in November 2016, December 2016, February 2017, and March 2017. The periods with missing data in the affected months were excluded in the data analysis going forward.
\nThe measured GHI and average irradiance profile are given in Figure 6(a), while Figure 6(b) shows the monthly average GHI and total irradiation over the measurement period.
\n(a) Measured and average global horizontal irradiance and (b) monthly average irradiance and total irradiance chart.
As seen in Figure 6(a), due to the measurement period considered, the winter dip, represented by June, July, and August months, was obtained at the right-hand side of the profile. This, however, did not affect the measured irradiance during the entire period. In agreement with theory [31, 32], the measured GHI as seen in Figure 4(a) ranges from 0 to 996.0 W/m2, where periods with the sun absent produce 0 W/m2 and the maximum irradiance of 996.0 W/m2 was logged in February 2017 at 12 h30. Furthermore, monthly average irradiance and total irradiation were developed to portray a typical sequential distribution of annual GHI at the southern hemisphere as shown in Figure 6(b). Also, the solar irradiance and irradiation distribution were predicted using a Gaussian function. The trend of the chart tends to correspond with the solar radiation distribution in the southern hemisphere [33]. In other words, a relatively lower solar irradiance of an average of 140.5 W/m2 was observed in June, July, and August, whereas the rest of the months had an average of 192.8 W/m2. Due to data loss and sky formation, an irregular distribution of solar irradiance was observed in January, February, November, and December. Hence, the red and blue band areas were used to indicate the period considered as summer and winter seasons, respectively, in the thermal performance evaluation of the house.
\nSolar irradiance across the north, east, south, and west elevations of a house varies due to daily movement of the sun. Consequently, heat transfer through the perimeter walls varies across the elevations [34]. The global irradiance at the various elevations was measured to depict the received solar irradiance and corresponding heat transfer through the windows. Daily summer and winter average global irradiance at the north, east, south, and west elevations, as well as their corresponding irradiation, is given in Figure 7.
\nMeasured solar global irradiance at the elevations of the house and corresponding heat energy on typical summer and typical winter days.
Practically, the sun travels daily from the east to the west through the north elevation in the southern hemisphere and the south elevation in the northern hemisphere [35, 36]. The measured solar irradiance at the building elevations in Figure 7 concords with the above concept. Hence the north elevation receives a significant amount of solar radiation during the day, while the south elevation receives minimum daily solar radiation. Nevertheless, the solar irradiance at the north and south elevations peaked at approximately the same time (mid-day). Also, both irradiance (north and south elevations) followed the same trend as the GHI. The solar irradiance at the east and west elevations was also observed to peak at the early and late hours of the day, respectively.
\nThe sharp dip in the west irradiance distribution was due to deciduous trees planted at the west side of the house. The trees were intended to shade the late afternoon sun and prevent cold winter wind. Further analysis of the solar radiation at the house elevations is given in Table 2.
\nBuilding elevation | \nSummer season | \nWinter season | \n||||||
---|---|---|---|---|---|---|---|---|
Average (W/m2) | \nMaximum (W/m2) | \nPeak time | \nDaily irradiation (kWh/m2) | \nAverage (W/m2) | \nMaximum (W/m2) | \nPeak time | \nDaily irradiation (kWh/m2) | \n|
North | \n215.1 | \n472.4 | \n12 h00 | \n3.23 | \n376.4 | \n741.5 | \n12 h30 | \n4.71 | \n
East | \n188.4 | \n510.7 | \n09 h30 | \n2.83 | \n156.0 | \n490.6 | \n9 h30 | \n1.95 | \n
West | \n123.4 | \n349.6 | \n14 h00 | \n1.85 | \n92.7 | \n311.7 | \n14 h00 | \n1.16 | \n
South | \n76.6 | \n126.7 | \n11 h00 | \n1.15 | \n44.2 | \n78.0 | \n12 h00 | \n0.55 | \n
Typical summer day solar global radiation at the house elevations.
As observed in Figure 7 as well as Table 1, the daily average winter irradiance at the north elevation was higher than the average GHI by 106.27 W/m2. It was also observed to be higher than the north elevation average irradiance by 161.27 W/m2 in the summer season. The relatively high north irradiance during the winter season which is due to the low-angle winter sun is the fundamental principle of passive solar design for heating concerning the ambient weather conditions. The north elevation outperformed the others regarding daily average and maximum irradiance as well as the daily irradiation, comparing other elevations in Table 1. The solar irradiation in Figure 7(a) and (b) serves as the instantaneous (30 min interval) heat energy received from the sun at the respective elevation, whereas, Table 1 gives the daily cumulative heat energy. Per day, the north elevation had the maximum heat energy during the winter season.
\nHeat transfer through the windows of a house is the sum of conductive and radiative heat transfer. During the day (present of the sun), both means of heat transfer coincide. While at night, conductive heat transfer is dominant. Due to the indoor and ambient air temperature difference, conductive heat transfer transpires through the windows. Conductive heat transfer through the windows is given as [37]
\nwhere \n
\n\n
Sol-air temperature at various elevations of a passive solar house on average summer and winter days.
In computing the sol-air temperature, longwave radiation factor \n
Typical summer and winter daily heat transfer through the windows of a passive solar house.
The sun is solely responsible for radiative heat transfer. Hence, radiative heat transfer only occurs during the period the sun is present, and it is referred to as solar heat gain. Equation (1) must be positive to achieve solar heat gain. However, the instantaneous radiative or solar heat gain through a window can be evaluated by
\nwhere \n
Therefore Eq. (3) can be rewritten as
\nHence, the instantaneous heat transfer through the house windows at the various elevations was computed by combining Eqs. (1) and (5) together with Figures 7 and 8. The resultant summer and winter daily heat transfer through the house windows is given in Figure 9(a) and (b), respectively.
\nThe following assumptions were made to obtain the profile given in Figure 10. The SHGC and U-value of a timber frame window are 0.77 and 5.6 W/m2 K, respectively [18]. In all windows excluding the clerestory windows, semiopen weave and medium colour single drapes were used. Hence, the SC of the windows was 0.51. On the other hand, no drapes were used in the clerestory windows; thus the SC was 0.95 [39]. The area of the frame and thermal lag factor of the windows were ignored. In terms of operation, all windows were closed at all times.
\nSeasonal daily windows’ cumulative heat energy.
In both figures, the north-facing windows had the maximum heat gain. This includes the clerestory and north perimeter windows. Heat gain through the clerestory windows was found to be maximum with 759 W at 14 h00 and 1356.50 W at 12 h30, in summer and winter, respectively. The daily average heat gain through the same windows was 507.72 W in summer and 896.51 W in winter. The north perimeter windows’ heat transfer follows the same trend but 79 and 41% lesser in summer and winter, respectively.
\nThe least heat gain was obtained at the south perimeter windows. Their daily average heat gain was 76.29 W in summer and 50.85 W in winter. Heat transfer through the south windows was 85% lesser than that of the clerestory windows in summer and 94% lower in the winter season. The clerestory windows also had the maximum heat loss. The daily average heat loss difference between the clerestory windows and the other perimeter windows was 15.62 and 14.42 W in summer and winter, respectively. Furthermore, the daily cumulative heat energy through the windows in summer and winter is given in Figure 10.
\nThe clerestory windows generate 3.10 kWh/m2/window in summer and 4.73 kWh/m2/window in winter. This results in 9.30 and 18.60 kWh/m2 daily cumulative heat energy generated in the living room and south-facing bedroom in summer, as well as 14.19 kWh/m2 in the living room and 28.38 kWh/m2 in the south-facing bedroom in winter. Once again, the south perimeter windows were the most underperforming. The daily cumulative heat energy gain through the south windows was 82 and 94% lesser than that of the clerestory windows in summer and winter, respectively. An average daily cumulative heat energy loss of 0.48 kWh/m2/window was obtained in all windows in summer. Also in winter, 0.52 kWh/m2/window was obtained. Besides, the east perimeter windows had the maximum heat energy loss with 0.45 kWh/m2/window in summer and 0.51 kWh/m2/window in winter.
\nThe clerestory windows show significant heat contribution to the inner space of the house. From the findings, it indicates that the clerestory windows were able to offset the underperforming south perimeter windows. Also, irrespective of size (glass surface area), the clerestory windows outperformed the other windows in both seasons in terms of heat gain. It can be said that the performance of the windows is a factor of the orientation of the house rather than the surface area of the windows (glass). Additionally, the solar heat gain through the windows was examined. The summer and winter daily average solar irradiation on the outer surface of the house windows and the resultant heat energy gain are given in Figures 11 and 12, respectively.
\nTypical summer day solar heat gain of the house north, east, south, west, and clerestory windows.
Typical winter day solar heat gain of the house north, east, south, west, and clerestory windows.
From Figure 11, the south perimeter windows had minimum heat energy transmission. It was found that 48%/window of solar irradiation was transmitted through the south perimeter windows. The clerestory windows, on the other hand, had the maximum heat energy transmission with 96%/window. Similar behaviour was observed in Figure 12. The south perimeter and clerestory windows heat energy transmission with respect to their solar irradiation were 52 and 101%/window, respectively. Detailed findings of the solar irradiation of the house windows and the resultant heat energy transmission are given in Table 3.
\nWindows | \nSummer | \nWinter | \n||
---|---|---|---|---|
Solar irradiation (kWh/m2) | \nTransmitted heat energy (%/window) | \nSolar irradiation (kWh/m2) | \nTransmitted heat energy (%/window) | \n|
North | \n3.23 | \n63 | \n4.71 | \n67 | \n
East | \n2.83 | \n60 | \n1.95 | \n63 | \n
South | \n1.15 | \n48 | \n0.55 | \n52 | \n
West | \n1.85 | \n57 | \n1.16 | \n61 | \n
Clerestory | \n3.23 | \n96 | \n4.71 | \n101 | \n
Seasonal solar heat energy transmitted through the windows.
As stated earlier, the heat energy transmitted through the windows (glass area) is due to simultaneous conductive and radiative heat transfer. Although, the above comparative analysis only took into consideration the radiative heat energy generated on the windows’ outer surface. Also, no shading device (drapes) was used in the clerestory windows. Hence, during the winter season, more than 100% of heat energy was transmitted through the clerestory windows.
\nThe indoor air temperature and relative humidity were the focus of the indoor weather conditions analysis. Thus, both parameters of each zone in the house were measured separately to establish the thermal influence of the various activities and orientation of the rooms (see Figure 4). The seasonal daily indoor air temperature and relative humidity profiles of the different zones in the house are given in Figure 13.
\nAverage summer and winter days’ air temperature and relative humidity distribution in the various zone.
In Figure 13, the vertical bar charts below and above represent the air temperature and relative humidity percentage difference, respectively, of the three zones. A minimal summer day air temperature and relative humidity percentage difference were observed. However, zone 3 had the maximum air temperature and relative humidity percentage difference in both days. On a typical summer day, the air temperature percentage difference was 4% at 12 h00 and a corresponding relative humidity of 3% at 11 h00. The air temperature and relative humidity percentage differences were, respectively, 16% and 12% on a typical winter day. Further findings of Figure 13 are summarised in Table 4.
\nZone | \n1 | \n2 | \n3 | \n|||
---|---|---|---|---|---|---|
Indoor weather parameter | \nTemp. (°C) | \nRH (%) | \nTemp. (°C) | \nRH (%) | \nTemp. (°C) | \nRH (%) | \n
Daily swing | \n5.4 | \n14.4 | \n5.8 | \n16.1 | \n5.7 | \n13.5 | \n
Max. per. diff. (%) (equiv. temp.) | \n4 (0.9°C) | \n2.9 (1.3%) | \n2 (0.5°C) | \n2.7 (1.2%) | \n4 (1.1°C) | \n3.1 (1.3%) | \n
Peak time | \n12 h00 | \n18 h30 | \n16 h00 | \n18 h30 | \n11 h00 | \n11 h00 | \n
Average per. diff. (%) (equiv. temp.) | \n2 (0.4°C) | \n0.9 (0.4%) | \n1 (0.2°C) | \n1.7 (0.8%) | \n1 (0.3°C) | \n1.1 (0.5%) | \n
Typical summer day indoor air temperature and relative humidity variation in the house zones.
In Tables 4 and 5, the daily swing refers to the difference between the daily maximum and minimum air temperature and relative humidity. In Table 4, a fairly constant daily air temperature swing with an average of 5.6°C was observed, although the relative humidity swing in each zone varies. This was expected given that the presence and activities of occupants in a room are an influencing factor of relative humidity.
\nZone | \n1 | \n2 | \n3 | \n|||
---|---|---|---|---|---|---|
Indoor weather parameter | \nTemp. (°C) | \nRH (%) | \nTemp. (°C) | \nRH (%) | \nTemp. (°C) | \nRH (%) | \n
Daily swing | \n6.1 | \n16.3 | \n6.7 | \n20.0 | \n9.6 | \n22.2 | \n
Max. per. diff. (%) (equiv. temp.) | \n11.6 (2.4°C) | \n6.5 (2.2%) | \n4.8 (0.9°C) | \n5.7 (1.9%) | \n16.2 (3.4°C) | \n12.2 (4.1%) | \n
Peak time | \n12 h00 | \n12 h00 | \n11 h00 | \n12 h00 | \n12 h00 | \n12 h00 | \n
Average per. diff. (%) (equiv. temp.) | \n2.2 (0.4°C) | \n3.1 (1.3%) | \n2.3 (0.4°C) | \n2.5 (1.0%) | \n3.9 (0.7°C) | \n3.6 (1.5%) | \n
Typical winter day indoor air temperature and relative humidity variation in the house zones.
Furthermore, varying air temperature and relative humidity were observed in each zone during the typical winter day. This implies that a relatively high diurnal temperature variation was experienced during the winter season. In addition, zone 3 had the maximum daily air temperature swing of 9.6°C. This was as a result of the north-facing clerestory windows. Recall that the house was designed to optimise even air temperature indoors. Hence, the clerestory windows were installed to distribute solar radiation to the south floor area of the house. The blue dash circles in Figure 13 indicate air temperature increase in zone 3 (south-facing room) due to penetrated solar radiation, consequently increasing the day and night air temperature differences in the zone. Zone 3 air temperature tends to increase more in winter due to the low-angled sun experienced during the season, regarding the blue circled area in both figures.
\nHowever, the average indoor air temperature and relative humidity in all zones were obtained and used to illustrate the indoor air temperature and relative humidity distribution within the thermal comfort zone. The average air temperature of all zones was represented by the whole building air temperature, while whole building relative humidity served as the average relative humidity of the three zones. Summer season frequency distribution of the whole building and ambient air temperature, as well as their corresponding relative humidity, are shown in Figure 14.
\nWhole building and ambient air temperature and relative humidity summer season profile.
A total of 12,607 data entries were used to develop the summer whole building and ambient air temperature and relative humidity distribution profile. As seen in Figure 14, the whole building and ambient air temperature distributions were divided into nine classes of 4.9°C width, and the air relative humidity frequency distribution curve is made of 11 classes of 9.99% width. Statistically, the whole building and ambient air temperature were not normally distributed. The whole building temperature skewness was 0.20 with a standard error (S.E) of 0.02, whereas a skewness of 0.41 (S.E 0.02) was obtained for the ambient temperature. Although both whole building and ambient air relative humidity in Figure 14 were also not normally distributed, an opposite skewness was obtained. The whole building and ambient relative humidity had a skewness of −23.32 and − 23.68, respectively, both with a S.E of 0.02.
\nThis implies that the measured air temperature and relative humidity deviate away from their mean towards the positive and negative side, respectively, where the whole building and ambient mean values are indicated by the blue broken (24°C) and solid (19°C) lines in their respective classes. The broken red line (47%) is used to identify the mean value of the whole building relative humidity, while the solid red line signifies the mean ambient relative humidity of 68%.
\nThermally in Figure 14, the solid grey line and band indicate the indoor air temperature (20 and 24°C) and relative humidity (30 and 60%) comfort zones, respectively [40]. In this regard, 49% of the whole building air temperature and approximately 85% of its corresponding relative humidity were found within the thermal comfort, whereas only 21 and 28% of the ambient air temperature and relative humidity, respectively, were in the thermal comfort zone.
\nIn the winter season, a total of 4386 data entries were used to develop the whole building thermal condition, ambient air temperature, and relative humidity distribution profile. Nonetheless, a similar behaviour of the whole building, ambient air temperature, and relative humidity were observed. Figure 15 shows the measured ambient and whole building air temperature as well as the resultant relative humidity during the winter season.
\nWhole building and ambient air temperature and relative humidity winter season profile.
From Figure 15, the whole building temperature and relative humidity skewness were 0.22 and −0.21, respectively, with a S.E of 0.04. Meanwhile, a skewness of 0.22 was observed for the ambient air temperature, while the relative humidity skewness was −0.15, both with a S.E of 0.04. Hence, the whole building, ambient air temperature, and relative humidity curves are asymmetric. In other words, the mean of the whole building air temperature drifts away from the thermal comfort zone, leaving only 23% of the whole building temperature distribution in the thermal comfort zone. However, the percentage of the ambient air temperature in the thermal comfort zone deviates by 10%, whereas approximately 78 and 29% of the whole building and ambient air relative humidity, respectively, were inside the thermal comfort zone.
\nBased on the findings, it could be said that the whole building air temperature to a certain degree is influenced by the ambient air temperature given that both distributions follow the same trend in both seasons. Nevertheless, the same cannot be said for the whole building and ambient air relative humidity. In both seasons, the whole building relative humidity distribution tends to follow the whole building air temperature.
\nTheoretically, relative humidity is a measure in percentage of the amount of water vapour in the air compared to the amount of water vapour the air can hold at a given temperature. Considering that the amount of water vapour the air can hold mainly depends on the air temperature, an increase in air temperature increases the capacity of water vapour the air can hold. At a fixed amount of water vapour, an increase in air temperature results in a decrease of the air relative humidity and vice versa. Therefore, the measured air temperature and relative humidity in Figures 14 and 15 are in line with theory.
\nThe aim of this study is to analyse the thermal performance of a prototype low-cost energy-efficient house in South Africa. A passive solar house in SolarWatt Park, Alice, was used in the study. The indoor and ambient weather conditions of the house were monitored. Indoor and outdoor air temperature, relative humidity, as well as global horizontal irradiance and global irradiance at the various elevations of the house constitute the weather conditions.
\nIt was found that strategic locating of the windows provides significant daylighting and heating for the inner space of the house. Also, the heat contribution of the windows was found to be dependent on the house orientation and shading materials (blind and drape). The performance of the north-facing clerestory and south-facing windows supports this claim. The daily cumulative heat contribution of the clerestory windows with no shading material was higher than that of the south-facing windows by 1.08 kWh/m2/windows in summer and 4.45 kWh/m2/windows in winter. Due to conductive and radiative heat transfer which co-occurs in the windows, the clerestory windows were found to transmit more than 100% of the solar radiative energy generated on the outer surface in winter. The performance of the clerestory windows as shown in the findings made it an essential component of direct solar heat gain strategy in passive solar design.
\nIt was also observed that the generated heat from the windows does not constitute overheating indoor. In summer, 49% of the whole building air temperature and approximately 85% of its corresponding relative humidity were found within the thermal comfort. Only 23% temperature and 78% relative humidity distributions of the whole building were in the thermal comfort zone in the winter season.
\nThis work was based on the research supported in part by the National Research Foundation of South Africa (Grant number 116763). We also acknowledge the Department of Science and Technology and Govan Mbeki Research and Development Centre for supporting this research.
\nThe authors declared no conflicts of interest regarding the authorship of this publication.
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\\n\\nOve Odredbe i uvjeti su sastavljeni u skladu s odredbama prava Ujedinjenog Kraljevstva, a za sve sporove nadležan je sud u Londonu, Ujedinjeno Kraljevstvo.
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\n\nBez prethodne privole i izričite pisane dozvole, ne možete stvarati okvire oko naših stranica ili koristiti druge tehnike koje na bilo koji način mogu promijeniti prezentaciju ili izgled naše stranice.
\n\nIntechOpen može ove Odredbe izmijeniti u bilo koje vrijeme i bez prethodne obavijesti. Koristeći ovu stranicu vi se slažete s trenutnim Odredbama i uvjetima koje su na snazi.
\n\nOve Odredbe i uvjeti su sastavljeni u skladu s odredbama prava Ujedinjenog Kraljevstva, a za sve sporove nadležan je sud u Londonu, Ujedinjeno Kraljevstvo.
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Abu-Eishah"}]},{id:"13747",doi:"10.5772/14702",title:"Application of Room Temperature Ionic Liquids in Electrochemical Sensors and Biosensors",slug:"application-of-room-temperature-ionic-liquids-in-electrochemical-sensors-and-biosensors",totalDownloads:9795,totalCrossrefCites:13,totalDimensionsCites:31,abstract:null,book:{id:"1373",slug:"ionic-liquids-applications-and-perspectives",title:"Ionic Liquids",fullTitle:"Ionic Liquids: Applications and Perspectives"},signatures:"Farnoush Faridbod, Mohammad Reza Ganjali, Parviz Norouzi, Siavash Riahi, and Hamid Rashedi",authors:[{id:"18565",title:"Prof.",name:"Mohammad Reza",middleName:null,surname:"Ganjali",slug:"mohammad-reza-ganjali",fullName:"Mohammad Reza Ganjali"},{id:"20605",title:"Dr.",name:"Parviz",middleName:null,surname:"Norouzi",slug:"parviz-norouzi",fullName:"Parviz Norouzi"},{id:"20606",title:"Dr.",name:"Farnoush",middleName:null,surname:"Faridbod",slug:"farnoush-faridbod",fullName:"Farnoush Faridbod"},{id:"20607",title:"Dr.",name:"Siavash",middleName:null,surname:"Riahi",slug:"siavash-riahi",fullName:"Siavash Riahi"}]}],mostDownloadedChaptersLast30Days:[{id:"20532",title:"1,2,3-Triazolium Salts as a Versatile New Class of Ionic Liquids",slug:"1-2-3-triazolium-salts-as-a-versatile-new-class-of-ionic-liquids",totalDownloads:6032,totalCrossrefCites:6,totalDimensionsCites:12,abstract:null,book:{id:"327",slug:"ionic-liquids-classes-and-properties",title:"Ionic Liquids",fullTitle:"Ionic Liquids - Classes and Properties"},signatures:"Zekarias Yacob and Jürgen Liebscher",authors:[{id:"52686",title:"Prof.",name:"Jürgen",middleName:null,surname:"Liebscher",slug:"jurgen-liebscher",fullName:"Jürgen Liebscher"},{id:"56807",title:"Prof.",name:"Zekarias Yacob",middleName:null,surname:"Fundusa",slug:"zekarias-yacob-fundusa",fullName:"Zekarias Yacob Fundusa"}]},{id:"72530",title:"Application of Vortex Control Principle at Pump Intake",slug:"application-of-vortex-control-principle-at-pump-intake",totalDownloads:1008,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Vortex flow in a pump intake could affect a pump operation significantly if not treated appropriately. Many researches have been conducted to determine the best control method for vortex flow in pump sumps so that the pump lifespan can be maximized. In this study, a vortex control principle designed to minimize the impact of submerged vortex flow in pump sump on major pump components is presented. This principle employs a device called the plate type floor splitter which serves the function of eliminating vortices formed on the sump floor and reduces the intensity of swirling motion in the intake flow. A pump sump model was built to carry out the study by installing a floor splitter plate sample under the pump suction inlet and the corresponding parameters used to quantify the swirl intensity known as the swirl angle was measured. Procedures for the measurement were conducted based on ANSI/HI 9.8-2018 standard. A numerical simulation was performed to study the flow in a full-scale pump sump. The results showed that the installation of floor splitter plate can eliminate vortices efficiently and reduce swirl angle significantly. However, optimization of floor splitter design is needed to achieve a reduction effect that can reduce swirl angles to an acceptable value of lower than 5° according to ANSI/HI 9.8-2018 standard.",book:{id:"10080",slug:"vortex-dynamics-theories-and-applications",title:"Vortex Dynamics Theories and Applications",fullTitle:"Vortex Dynamics Theories and Applications"},signatures:"Zambri Harun, Tajul Ariffin Norizan and Wan Hanna Melini Wan Mohtar",authors:[{id:"243152",title:"Dr.",name:"Zambri",middleName:null,surname:"Harun",slug:"zambri-harun",fullName:"Zambri Harun"},{id:"313310",title:"Mr.",name:"Tajul Ariffin",middleName:null,surname:"Norizan",slug:"tajul-ariffin-norizan",fullName:"Tajul Ariffin Norizan"},{id:"317421",title:"Dr.",name:"Wan Hanna Melini",middleName:null,surname:"Wan Mohtar",slug:"wan-hanna-melini-wan-mohtar",fullName:"Wan Hanna Melini Wan Mohtar"}]},{id:"20216",title:"Ionic Liquids in Separation Techniques",slug:"ionic-liquids-in-separation-techniques",totalDownloads:8523,totalCrossrefCites:4,totalDimensionsCites:7,abstract:null,book:{id:"1300",slug:"applications-of-ionic-liquids-in-science-and-technology",title:"Applications of Ionic Liquids in Science and Technology",fullTitle:"Applications of Ionic Liquids in Science and Technology"},signatures:"Jolanta Flieger and Anna Czajkowska-Żelazko",authors:[{id:"20797",title:"Dr.",name:"Jolanta",middleName:null,surname:"Flieger",slug:"jolanta-flieger",fullName:"Jolanta Flieger"},{id:"136020",title:"Prof.",name:"Czajkowska",middleName:null,surname:"Żelazko",slug:"czajkowska-zelazko",fullName:"Czajkowska Żelazko"}]},{id:"71403",title:"Supercritical-Fluids Thermophysical Properties and Heat Transfer in Power-Engineering Applications",slug:"supercritical-fluids-thermophysical-properties-and-heat-transfer-in-power-engineering-applications",totalDownloads:1135,totalCrossrefCites:3,totalDimensionsCites:2,abstract:"Researches on specifics of thermophysical properties and heat transfer at supercritical pressures (SCPs) started as early as the 1930s with the study on free-convection heat transfer to fluids at a near-critical point. In the 1950s, the concept of using SC “steam” to increase thermal efficiency of coal-fired thermal power plants became an attractive option. Germany, USA, the former USSR, and some other countries extensively studied heat transfer to SC fluids (SCFs) during the 1950s till the 1980s. This research was primarily focused on bare circular tubes cooled with SC water (SCW). However, some studies were performed with modeling fluids such as SC carbon dioxide and refrigerants instead of SCW. Currently, the use of SC “steam” in coal-fired thermal power plants is the largest industrial application of fluids at SCPs. Near the end of the 1950s and at the beginning of the 1960s, several studies were conducted to investigate a possibility of using SCW as a coolant in nuclear reactors with the objective to increase thermal efficiency of nuclear power plants (NPPs) equipped with water-cooled reactors. However, these research activities were abandoned for some time and regained momentum in the 1990s. In support of the development of SCW-cooled nuclear-power reactor (SCWR) concepts, first experiments have been started in annular and various bundle flow geometries. At the same time, more numerical and CFD studies have been performed in support of our limited knowledge on specifics of heat transfer at SCPs in various flow geometries. As the first step in this process, heat transfer to SCW in vertical bare tubes can be investigated as a conservative approach (in general, heat transfer in fuel bundles will be enhanced with various types of appendages, that is, grids, end plates, spacers, bearing pads, fins, ribs, etc.). New experiments in the 1990–2000s were triggered by several reasons: (1) thermophysical properties of SCW and other SCFs have been updated from the 1950s–1970s, for example, a peak in thermal conductivity in the critical/pseudocritical points was “officially” introduced in 1990s; (2) experimental techniques have been improved; (3) in SCWRs, various bundle flow geometries will be used instead of bare-tube geometry; (4) in SC “steam” generators of thermal power plants, larger diameter tubes/pipes (20–40 mm) are used, however in SCWRs hydraulic-equivalent diameters of proposed bundles will be within 5–12 mm; (5) with Research and Development (R&D) of next-generation or Generation-IV nuclear-power-reactor concepts, new areas of application for SCFs have appeared—for example, SCP helium was proposed to be used as a reactor coolant, SCP Brayton and Rankine cycles with SC carbon dioxide as a working fluid are being developed, etc. A comparison of thermophysical properties of SCFs with those of subcritical-pressure fluids showed that SCFs as single-phase fluids have unique properties, which are close to “liquid-like” behavior below critical or pseudocritical points and are quite similar to the behavior of “gas-like” substances above these points. A comparison of selected SCW heat transfer correlations has shown that their results may differ from one to another by more than 200%. Based on these comparisons, it became evident that there is a need for reliable, accurate, and wide-range SCW heat transfer correlation(s) to be developed and verified. Therefore, the objective of this chapter is to summarize in concise form specifics of supercritical-fluids thermophysical properties and heat transfer in power-engineering applications.",book:{id:"9201",slug:"advanced-supercritical-fluids-technologies",title:"Advanced Supercritical Fluids Technologies",fullTitle:"Advanced Supercritical Fluids Technologies"},signatures:"Igor L. 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He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). He was the head of the undergraduate program in Biomedical Engineering of the Federal University of Uberlândia (2015 - June/2019) and the head of the Centre for Innovation and Technology Assessment in Health (NIATS/UFU) since 2010. He is the head of the Postgraduate Program in Biomedical Engineering (UFU, July/2019 - to date). He was the secretary of the Parkinson's Disease Association of Uberlândia (2018-2019). Dr. Andrade's primary area of research is focused towards getting information from the neuromuscular system to understand its strategies of organization, adaptation and controlling in the context of motor neuron diseases. His research interests include Biomedical Signal Processing and Modelling, Assistive Technology, Rehabilitation Engineering, Neuroengineering and Parkinson's Disease.",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",isOpenForSubmission:!0,editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",biography:"Dr. Luis Villarreal is a research professor from the Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Tijuana, Baja California, México. 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For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. 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His fields of interest are anterior segment disease, keratoconus, glaucoma, corneal dystrophies, and cataracts. His research topics include\nintraocular lens power calculation, eye modification induced by refractive surgery, glaucoma progression, and validation of new diagnostic devices in ophthalmology. \nHe has published more than 100 papers in international and Italian scientific journals, more than 60 in journals with impact factors, and chapters in international and Italian books. 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His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. 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He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. from Integral University, Lucknow, India, with his work titled ‘Development and evaluation of silymarin nanoformulation for hepatic carcinoma’. Currently, he is an Assistant Professor of Pharmaceutics, at the Faculty of Pharmacy, Integral University. He has been teaching PharmD, BPharm, and MPharm students and conducting research in the novel drug delivery domain. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than twenty-four original journal articles, two edited books, four book chapters, and several scientific articles to his credit. He is a member of the American Association for Cancer Research, the International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"333824",title:"Dr.",name:"Ahmad Farouk",middleName:null,surname:"Musa",slug:"ahmad-farouk-musa",fullName:"Ahmad Farouk Musa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333824/images/22684_n.jpg",biography:"Dato’ Dr Ahmad Farouk Musa\nMD, MMED (Surgery) (Mal), Fellowship in Cardiothoracic Surgery (Monash Health, Aust), Graduate Certificate in Higher Education (Aust), Academy of Medicine (Mal)\n\n\n\nDato’ Dr Ahmad Farouk Musa obtained his Doctor of Medicine from USM in 1992. He then obtained his Master of Medicine in Surgery from the same university in the year 2000 before subspecialising in Cardiothoracic Surgery at Institut Jantung Negara (IJN), Kuala Lumpur from 2002 until 2005. He then completed his Fellowship in Cardiothoracic Surgery at Monash Health, Melbourne, Australia in 2008. He has served in the Malaysian army as a Medical Officer with the rank of Captain upon completing his Internship before joining USM as a trainee lecturer. He is now serving as an academic and researcher at Monash University Malaysia. He is a life-member of the Malaysian Association of Thoracic & Cardiovascular Surgery (MATCVS) and a committee member of the MATCVS Database. He is also a life-member of the College of Surgeons, Academy of Medicine of Malaysia; a life-member of Malaysian Medical Association (MMA), and a life-member of Islamic Medical Association of Malaysia (IMAM). Recently he was appointed as an Interim Chairperson of Examination & Assessment Subcommittee of the UiTM-IJN Cardiothoracic Surgery Postgraduate Program. As an academic, he has published numerous research papers and book chapters. He has also been appointed to review many scientific manuscripts by established journals such as the British Medical Journal (BMJ). He has presented his research works at numerous local and international conferences such as the European Association for Cardiothoracic Surgery (EACTS) and the European Society of Cardiovascular Surgery (ESCVS), to name a few. He has also won many awards for his research presentations at meetings and conferences like the prestigious International Invention, Innovation & Technology Exhibition (ITEX); Design, Research and Innovation Exhibition, the National Conference on Medical Sciences and the Annual Scientific Meetings of the Malaysian Association for Thoracic and Cardiovascular Surgery. He was awarded the Darjah Setia Pangkuan Negeri (DSPN) by the Governor of Penang in July, 2015.",institutionString:null,institution:{name:"Monash University Malaysia",country:{name:"Malaysia"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}}]}},subseries:{item:{id:"26",type:"subseries",title:"Machine Learning and Data Mining",keywords:"Intelligent Systems, Machine Learning, Data Science, Data Mining, Artificial Intelligence",scope:"The scope of machine learning and data mining is immense and is growing every day. It has become a massive part of our daily lives, making predictions based on experience, making this a fascinating area that solves problems that otherwise would not be possible or easy to solve. This topic aims to encompass algorithms that learn from experience (supervised and unsupervised), improve their performance over time and enable machines to make data-driven decisions. 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Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",fullName:"Abdulsamed Kükürt",profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",institutionString:null,institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}},{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/47973",hash:"",query:{},params:{id:"47973"},fullPath:"/chapters/47973",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()