Simulation condition of wind speed distribution around buildings
\r\n\t
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He has more than sixty-five research papers published in international journals and conferences and has conducted and been involved in more than ten national and international research projects. He performed seismic evaluation or design of seismic retrofit systems for more than 150 RC buildings and provided consultancy for structural engineering studies. 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In all over the world, there is continuous encouragement to increase the penetration of environment friendly energy sources for fulfilling growing energy demand and also to minimize the use of hydro-carbon based power plants. Renewable energy sources such as wind, photovoltaic (PV), solar thermal, geothermal, bio-energy are drawing attention from the world as alternative environment friendly energy sources. The energy density of these renewable energy sources is low. Most of them are dependent on nature and are found intermittent. It is very important to develop proper strategies to integrate these renewable energy sources into the power system network for fulfilling the energy demand. As cities around the world are experiencing exponential growth and there is urgent need to ensure that cities should expand sustainably, operate efficiently, and maintain a high quality life of residents. One of a city’s most important critical infrastructures of a city is reliable power supply network. The smart city is an effective way to integrate renewable energy sources into the existing energy system network. In Japan, some demonstration projects of smart city are under contemplation [1]. In China, Tianjin City is being rebuilt as an ecological city by project in collaboration with a Singapore company [2]. Such type of trend will continue and in near future many cities will be rebuilt as smart city.
In a smart city planning, it is very important to consider the future growth of building integrated environment friendly energy systems. Energy output from intermittent renewable energy sources in the built environment depends on the availability of natural resources (e.g. wind speed, solar radiation, etc.) in the urban area. In the built environment, it will be challenging to integrate intelligently renewable energy sources and distributed generators as the existing building infrastructure are not designed to integrate them into the power system infrastructure. In future smart city planning, it is very important to consider proper intelligent integration of renewable energy sources into the built environment. A smart city development and deployment of building integrated renewable energy system has to harmonize with expansion of the combined heat and power system infrastructure, the information and communication infrastructure, the transport infrastructure, and with integration of new secure monitoring and control applications [3].
This chapter intends to propose a smart city for utilizing renewable energy sources as much as possible. For example, the city consists of many buildings and the buildings are thought to be an obstacle to natural wind flow. If the wind movements through building layouts are controlled, then there is possibility that the wind can be utilized for power generation through wind turbine. In addition, solar power can be utilized by installing solar panels on the roof and/or side wall of the buildings. The proper building design can help to utilize the available solar radiation for generating power and heat through solar energy systems. For designing a building in smart city, building dimensions and layouts are very important for effective utilization of wind speed and solar radiation. It has been observed that, there is very limited research and project works, which are investigating these issues. This chapter is providing study on large scale power generation by wind turbine and PV systems integrated with building and in the city. In this study, the horizontal axis wind turbine is considered for integrating with city infrastructure and the output of commercial horizontal axis wind turbine is much larger compared to that of the commercial vertical axis wind turbine. Additionally, the building integrated with PV systems is considered. The proposed schematic of smart buildings integrated with wind turbine and PV system is given in Figure 1.
Image of smart buildings integrated with wind turbine and PV system proposed by this study
In a smart city, it is very important to analyze the wind speed and their directions flow. The analysis of wind flows around the buildings is done through numerical simulations and most of them are using turbulent model such as standard
Building layouts for wind speed profile and wind power generation
In this study, building layouts are considered for producing higher wind turbine power output in built environment [25, 26]. The configuration of building layouts like nozzle, as shown in Figure 2, is proposed and investigated to obtain the tapered wind flow through the buildings. Two buildings are configured as a nozzle (Figure 1) and the building size is taken 10 m width, 40 m length, and 40 m height. The representative length of this model
In this section, a commercial CFD software CFD-ACE+(WAVE FRONT) is adopted for numerical simulation of wind speed distribution in the built environment. This CFD software has many simulation code/tools for solving the multi-dimensional fluid dynamics. The validation of the simulation procedure of this CFD software has been well established [28-33]. The standard
where
The momentum equation is given by [34, 35]:
where
In the CFD software, the standard
where
Simulation condition of wind speed distribution around buildings
Table 1 lists the simulation parameters of wind speed distribution around buildings. The simulation model is already shown in Figure 2. Numerical simulation has been carried out under steady state by standard
where
In this study, the wind speed data for Tsu city in Japan are used from the Japan Meteorological Agency [37] for five years (from 2007 to 2011). The buildings locations are considered as a nozzle, therefore the wind inflow direction is important for obtaining the wind blowing through the buildings. The layouts of the buildings are decided based on the wind speed direction. The wind speed directions and building layouts are given in Figure 3. If the main wind direction is North (N), the wind from North-West (NW), North-North-West (NNW), North-North-East (NNE) and North-East (NE) including North can be utilized for blowing the wind among the buildings through proposed nozzle. Assuming the symmetry to the main wind direction, the wind speed distributions around the buildings for the in-flow angles
where
The top layer of the model has been considered free (without any disturbance). The slip on side wall of building is set by the following equation:
where
Wind speed directions and layouts of buildings
It is assumed that buildings are multi storied apartments. According to the statistical data collected by ministry of internal affairs and communications in Japan [38], the average floor area of dwelling in Japan is about 100 m2 per household. The height of one floor is assumed as 4 m. Assuming that four households stay per floor, the floor space is 400 m2. In this study, for simulating a nozzle by buildings orientation, the width and depth of building are set at 10 m and 40 m, respectively. The height of building should be set over the height of wind turbine if we request an accelerated wind by blowing through buildings. In this study, the real commercial wind turbine is considered for estimating the power generated by wind speed distribution. AEOLOS wind turbine of 50 kW class [36] is used. Table 2 provides the specification of the wind turbine. The hub height and rotor radius of this turbine are 30 m and 9 m, respectively, resulting that the height of building of 40 m is almost same as axis height of wind turbine.
Specifications of wind turbine
The wind in back area of the building is considered to be available for power generation from wind turbine, as the wind would be accelerated by blowing through nozzle created by buildings layouts/orientations. Three points at the back of buildings, which are apart from the buildings by 20, 30, 40 m (
where
where
Here, the wind speed and wind energy to
The power curve of AEOLOS wind turbine of 50 kW class is shown in Figure 4. The authors derive the empirical equation from the data of power curve, which is provided by AEOLOS. Figure 4 indicates the relationship between wind and power, resulting that the power generated by this wind turbine can be estimated by using the power curve. The power curve which is adopted in this study is as follows:
where
Power curve of wind turbine
The power generated by PV system is calculated by using the following equation [39]:
where
where
where
where
The contours of wind speed distribution in
To investigate the location point of wind turbine, the contours of wind speed
Contour of wind speed
Contour of wind speed
The wind speed distribution in the swept rotor area of wind turbine is important for estimating the wind turbine power output. The frequency distribution of
Frequency distribution of wind speed
This study carries out the 3D simulation and investigates the wind speed distribution toward
Frequency distribution of wind speed
In order to decide the location of the wind turbine in proposed building layouts, the wind directions are considered (Figures 2 and 3) in the actual area of Tsu city. Annual wind direction distribution in Tsu city is given in Figure 9 and it is based on the wind speed data provided by the Japan Meteorological Agency [37]. The hourly measurement data from 2007 to 2011 are used for estimation of annual wind direction distribution.
Annual wind direction distribution in Tsu city
It is observed from Figure 9 that the main wind direction throughout the year is North-West (NW). In this study, it is assumed that the open tip of building model is located as facing with the main wind direction (refer to Figure 3). West-North-West (WNW), North-North-West (NNW) and North (N) in addition to North-West (NW) are the wind directions, which can blow the wind among the buildings through nozzle. In this study, it is assumed that the wind blowing from the directions except for the above described five wind directions cannot be utilized for power generation of wind turbine. The different inflow angle conditions are considered in the simulation for finding the direction of wind in the proposed building layouts. As an example of the simulation results, the contours of wind speed
Contour of wind speed
The hourly data on wind speed and direction are used as inputs in the simulation for finding the wind turbine power output at a location of wind turbine in the proposed building layouts. The daily power energy outputs of wind turbine, which is installed at the location of the proposed building layout, for months January, April, July, and October are given in Figures 11, 12, 13, and 14, respectively. These four months are considered as representative of four seasons.
Variation of wind energy output in January in case of installing proposed building layouts in Tsu city (
Variation of wind energy output in April in case of installing proposed building layouts in Tsu city (
Variation of wind energy output in July in case of installing proposed building layouts in Tsu city (
Variation of wind energy output in October in case of installing proposed building layouts in Tsu city (
From these figures, it is observed that higher power energy of wind turbine can be obtained in the daytime irrespective of month/season. In addition, the higher amount of total wind energy through a day is obtained in January, while the lower amount of total wind energy through a day is obtained in July (in comparison with these four representative months). The main wind direction in July is East-South-East (ESE) and it is shown in Figure 15, while the main wind direction throughout the year is North-West (NW). In this study, it is assumed that the winds blowing from the restricted wind directions can be utilized for power generation from wind turbine. The restricted wind directions mean five directions whose center is the main wind direction, and the other four directions are located symmetry to the main wind direction. The amount of wind energy production is estimated to be zero for the wind blowing from the other directions. The monthly main wind direction is East-South-East (ESE) in July as shown in Figure 15, which is different from the annual main wind direction. The frequency of wind blowing from the restricted five directions is small in July, resulting that the wind energy production is lower compared to the other months. Therefore, while selecting the building orientations, it is very important to consider the wind speed directions in order to maximize annual wind energy production.
Frequency distribution of wind direction in July in Tsu city
To maximize the power output of PV system, it is important to set the tilt angle of solar panel normal to the solar orbit. Hence, this study investigates the optimum tilt angle for installing PV system on roof of the proposed building model in Tsu city. By examining the data of solar radiation intensity in Tsu city for five year from 1999 to 2009 [44], the best tilt angle is 35 degree (Figure 16). Therefore, this study estimates the power output of PV system installed on roof of a building whose tilt angle is 35 degree. In addition, this study assumes that the PV arrays face to the south.
Effect of tilt angle of PV array assumed to be installed in Tus city on amount of annual solar radiation intensity
The daily power outputs from PV system, for months January, April, July, and October, are given in Figures 17, 18, 19, and 20, respectively. The hourly meteorological measurement data of solar radiation intensity from 1990 to 2009 [44] and that of temperature and wind velocity from 2010 to 2011 [37] which are averaged among all days in each month are used for estimation of daily power outputs of PV system.
Figures 17, 18, 19, and 20 provide the output of PV system with respect to the time. Though the solar radiation intensity in July is high, the power generation from PV system is reduced due to high temperature (as explained by Eq. (19)). Because the solar radiation is relatively high and temperature is not high in April compared to the other months/seasons, therefore the PV system has good performance in month April.
Variation of PV energy output in January in case of installing in Tsu city
Variation of PV energy output in April in case of installing in Tsu city
Variation of PV energy output in July in case of installing in Tsu city
Variation of PV energy output in October in case of installing in Tsu city
This study investigates the power generation performance of a wind turbine and PV system integrated with two buildings and the power supply characteristics from this combined power generation system with electric demand are presented. In the building model of this study, one wind turbine and two PV arrays of 67.7 kWp per two buildings are assumed to be installed. As described above, by using the meteorological data [37, 44], the daily power outputs of wind turbine and PV system for each month throughout a year and annual power outputs from them are estimated. As a result, the annual electrical energy production of combined power generation system is 153 MWh. A typical monthly electric consumption for a household in Japan (for year 2012) is 276 kWh [45], resulting that the annual electric consumption for the proposed building model, which has 80 households per two buildings, is 265 MWh. Therefore, this combined power generation system can cover the 57.7% of the annual electric consumption of households assumed to be living in the building model. In the future study, the change of self-sufficient ratio with time will be investigated by collecting the statistical data of electric consumption.
To compare the power supply characteristics of this combined power generation system with the electric demand characteristics by the other consumer, the energy data base of Mie university [46] which is located in Tsu city is adopted. The data of daily electric consumption in weekday from 2010 to 2011 is used from this data base. Then, the daily data of a representative one day in each month is estimated by averaging all daily data through week days in each month. In this estimation, the electric consumption of Mie university per floor space is calculated from the data base and applied to the floor space of the building model, resulting that the amount of daily electric consumption for this building model is derived.
Figures 21, 22, 23, and 24 show the daily power outputs of wind turbine, PV system, and combined them for months January, April, July, and October. Additionally, the daily self-sufficient ratio of combined power generation system, which is a ratio of electrical energy generation to electric consumption, is also shown. From these figures, it is clear that the electrical energy of combined power generation system as well as that of wind turbine or PV system in daytime is larger than nighttime. As the electric consumption of university in daytime is also larger than nighttime, the characteristics of power supply by combined power generation system matches the characteristics of electric consumption of university. The self-sufficient ratio of combined power generation system in daytime is approximately 20 – 60 %, while that in nighttime is below 20 %. The average self-sufficient ratios of combined power generation system in all the day for January, April, July, and October are 23.3 %, 30.0 %, 15.7 %, and 19.9 %, respectively. The highest self-sufficient ratio of combined power generation system is obtained in April. Because April is the moderate season in Japan, the electric consumption is relatively small compared to summer and winter. In addition, the amount of power energy of PV system in April is higher compared to the other months/seasons as described above. Consequently, the self-sufficient ratio of combined power generation system in April is the best. On the other hand, the self-sufficient ratio of combined power generation system in July is lower compared to the other months/seasons. In July, the electric consumption is high due to hot season in Japan. In addition, the power energy of combined power generation system is low because the meteorological condition is not good for wind turbine and PV system as described above. Therefore, the self-sufficient ratio of combined power generation system in July shows the small value relatively.
Variation of energy output of each power generation system and self-sufficient ratio of power generation to electric consumption in January
Variation of energy output of each power generation system and self-sufficient ratio of power generation to electric consumption in April
Variation of energy output of each power generation system and self-sufficient ratio of power generation to electric consumption in July
Variation of energy output of each power generation system and self-sufficient ratio of power generation to electric consumption in October
The proposed model of combined built environment renewable energy supply system is effective for reducing the usage of the power generated by thermal power plant, i.e., it is effectively reducing the significant amount of CO2 emission. To improve the performance of the proposed building model, the following investigations are suggested:
The effect of building size and layout on the wind speed distribution around buildings and power generation performance of built environment wind turbine should be investigated. For example, though the angle between two buildings of 90 degree is proved to be effective for accelerating the wind, the other angles have a possibility to produce higher power from wind turbine. As an example, the wider angle such as 135 degree can suck the wind inside the nozzle shaped building model. If the speed of accelerated wind obtained by the building model whose angle between two building is 135 degree is comparable to that by the building model whose angle between two building is 90 degree, the power generated by wind turbine is larger due to increase in the number of wind direction whose wind can be utilized for power generation. However, it is believed that there is the optimum building size and layout to obtain higher wind acceleration effectively because it is difficult to make a contracted flow by too wider angle between two buildings.
To select the area where the wind direction is not changed throughout the year is necessary to obtain the high accelerated wind by the proposed building model. The wind blowing from the main wind direction is the most desirable to realize the high performance of the proposed building model. Therefore, the research on the optimum area for installing the building model is important. Otherwise, the building layout should be changed by increasing the number of buildings. If the four buildings are located like a cross with keeping the space at the center for installing a wind turbine, the wind from every wind direction might be tapered.
Though the tilt angle of PV array is optimized by examining the data of solar radiation, the installation direction of PV array is fixed opening towards south. If the system tracking solar orbit is considered in the proposed building model, the power output of PV system increases. In addition, the effect of installing PV modules on side wall of buildings is effective for increasing the power generated from PV system.
Feasibility study on the proposed building model by assuming the installation of it in more different actual areas should be carried out. By investigating the versatility of the proposed building model under the various meteorological conditions, the assumption and building size and layout which are set in the model would be improved to match the actual meteorological condition.
As an application model to meet the electric demand more, the building model including secondary battery and fuel cell systems as well as wind turbine and PV system can be imaginable. If there is a miss match between the power supply of combined renewable power generation system such as wind turbine and PV and electric consumption, the secondary battery or fuel cell system can provide the power to cover the miss match. In order to produce the hydrogen for fuel cell, the solar thermal chemical conversion from ammonia to hydrogen is also promising. The renewable energy can be stored as an electro-chemical energy and it can be used as energy source when it is needed. Solar thermal chemical conversion can also help in overcoming the miss match between the power supply of combined renewable power generation systems and electric demand.
In this chapter, building topologies/orientations/layouts in a smart city are investigated for finding out the wind speed distribution profiles in the built environment. The analysis of wind speed distribution and directions are very important for not only to find the mechanical wind stress but also to find the energy content in the wind and a location for wind turbine in built environment. This analysis is also useful for designing the building layouts in such a way to make the nozzle of the wind by using wind directions and then finding out the proper location of the wind turbine in smart city. In this work, building layouts like nozzle is proposed and investigated to obtain the contracted flow by blowing wind through the buildings. The output power of wind turbine is estimated by using the power curve of real wind turbine and the wind speed distribution around buildings by using the wind speed data for Tsu city (Japan). This chapter also investigates the power generation performance of PV system installed on a roof of the building by using the actual meteorological data of Tsu city. The power generation characteristics of the combined system including wind turbine and PV assumed to be operated under the actual meteorological conditions, is evaluated and compared with the electric consumption profile of the consumer assumed to utilize/occupy the building. The main conclusions obtained from these investigations are as follows:
In case of
Because
In case of installing the building model in Tsu city, the higher wind energy output is obtained in the daytime irrespective of the month/season. The higher wind energy output throughout the day is available in January, while the lower wind energy output is available in July.
In case of installing the building model in Tsu city, the highest total amount of power energy generated by PV system in throughout the day is obtained in month April as the solar radiation is relatively high and temperature is not high compared with the other months/seasons.
The combined power generation system proposed by this study can cover the 57.7% of the annual electric consumption of households assumed to be living in the building model.
Comparing the power generation characteristics of the combined power generation system with the electric consumption characteristics of university, it is known that the self-sufficient ratio of combined power generation system in daytime is approximately 20 – 60 %, while that in nighttime is below 20 %. The highest self-sufficient ratio of combined power generation system is available in April, while the lowest self-sufficient ratio is available in July.
In order to realize the energy supply system with CO2 free by improving the power generation performance of the proposed building model and energy supply adaptability to energy demand, the further investigation such as the optimization of building configuration/layouts and modeling of new combined system including power generation, energy preservation, and energy conversion is needed in near future.
The biliary ileum is defined as a mechanical intestinal obstruction due to the impact of one or more gallstones in the gastrointestinal tract and is a rare complication of cholelithiasis. The term “ileum” is an improper term, since obstruction is a true mechanical phenomenon [1, 2], while gastrointestinal obstruction from gallstones would be an appropriate term. Biliary ileum is not very common and diagnosis and treatment can be problematic.
\nBiliary ileus causes 1–4% of all cases of obstruction of the small intestine. This is 25% in patients over 65 years of age and is responsible for about three of the 10 million admissions to hospital and 15 for about 1 million surgical procedures (0.0015%). It is more common in women than in men with a 5:1 female-to-male ratio.
\nThe biliary ileum is often preceded by an initial episode of acute cholecystitis. Inflammation in the gallbladder and surrounding structures leads to the formation of adhesion. Inflammation and the pressure effect of gallstones causes erosion through the gallbladder wall, leading to the formation of fistulas between the gallbladder and the adiacent portion of the gastrointestinal tract, with further passage of gallstones [3, 4]. Less commonly, a gallstone can enter the duodenum through the common bile duct and through a dilated papilla of Vater [5]. The most frequent fistula occurs between the gallbladder and the duodenum due to their proximity [6, 7, 8, 9]. The stomach, small intestine, and transverse portion of the colon may also be involved (Table 1) [1, 2, 3, 4, 10, 11].
\nColecystoduodenal | \n32.5 to 96.5 | \n
Colecystogastric | \n0 to 13.3 | \n
Colecystoduodenal | \n0 to 2,5 | \n
Colecystoileal | \n0 to 2,5 | \n
Colecystocolic | \n0 to 10.9 | \n
Frequency of bilio-enteric fistulas in patients with ileus from gallstones.
Once inside the duodenal, intestinal, or gastric lumen, gallstones usually proceed distally and can pass spontaneously through the rectum, or they can cause obstruction. Less commonly if the bile stone is in the stomach, proximal migration can occur and the bile stone can be vomited [4]. The size of the gallstones, the site of fistula formation, and the intestinal lumen will determine whether or not intestinal obstruction will occur. Most gallstones less than 2–2.5 cm can pass spontaneously through a normal gastrointestinal tract and will be excreted in the stool without problems [1, 2, 3, 4]. Clavien et al. [12] reported that an obstructive gallstone size ranges from 2 to 5 cm. Nakao et al. [6] found that gallstones had sizes ranging from 2 to 10 cm, with an average of 4.3 cm. The obstruction site can be found in any portion of the gastrointestinal tract. If gallstones enter the duodenum, the most common intestinal obstruction will be the terminal ileum and ileocecal valve due to their relatively narrow lumen and potentially less active peristalsis. Less frequently, gallstones obstruct the proximal ileum or jejunum, especially if the gallstones are large enough. Less common positions include the stomach and duodenum (Bouveret syndrome) and colon (Table 2) [1, 3, 4, 8, 9, 13].
\nDuodenum | \n0-10.5 | \n
Stomach | \n0-20 | \n
Proximal ileus | \n0-50 | \n
Distal ileus | \n0-89.5 | \n
Colon | \n0-8.1 | \n
Undetermined | \n0-25 | \n
Place range (%).
The presence of diverticula, neoplasms, or intestinal stenoses secondary to Crohn’s disease, reduce the size of the lumen and can cause an occlusion of gallstones on the narrowing site [1, 2, 3, 14]. Biliary ileum has been reported at anastomosis sites after partial gastrectomy and Billroth II reconstruction and after biliointestinal bypass in two cases [15, 16]. Ischemia can develop at the occlusion site of gallstones due to the pressure generated against the intestinal wall and proximal distension. Necrosis and perforation may occur followed by peritonitis [3]. The presentation of the biliary ileum may be preceded by a history of previous biliary symptoms, with rates ranging between 27 and 80% of patients [7, 12, 13, 17, 18, 19]. Acute cholecystitis can be present in 10–30% of patients at the time of intestinal obstruction. Jaundice was found in only 15% of patients or less. Bile symptoms can be absent in up to a third of cases [1, 2, 3, 8, 9, 12, 20, 21].
\nThe biliary ileum can manifest itself as an acute, intermittent, or chronic episode of gastrointestinal obstruction. Nausea, vomiting, cramping abdominal pain, and variable distension are commonly present [1, 3, 8, 12, 13, 20, 22, 23, 24, 25, 26, 27, 28, 29]. The intermittent nature of pain and vomiting of the proximal gastrointestinal material, which later becomes dark and fecaloid, is due to partial or total occlusion of gallstones [5, 18]. The character of vomiting depends on the location of the obstruction. When gallstones are in the stomach or upper small intestine, vomiting is mainly gastric in content (becoming fecaloid when the ileum is obstructed). In particular, Bouveret’s syndrome presents signs and symptoms of gastric outlet obstruction. Nausea and vomiting were reported in 86% of cases, while abdominal pain or discomfort was reported in 71%. If the bile stone does not completely obstruct the lumen, the presentation will be partially obstructed. Recent weight loss, anorexia, early satiety, and constipation can be reported by the patient. Bouveret syndrome has also been reported to be preceded by bleeding of the upper gastrointestinal tract secondary to duodenal erosion caused by gallstones, with hematemesis and melena, respectively, in 15 and 7% [8, 9, 30, 31]. The physical examination can be nonspecific. Patients are often seriously ill, with signs of dehydration, abdominal distension, and decrease in intestinal peristalsis and obstructive jaundice. Fever, toxicity, and physical signs of peritonitis can be noted if perforation of the intestinal wall occurs. The examination can be completely normal if no obstacles are currently present [1, 2, 3, 4, 30].
\nThe symptoms and signs of the biliary ileum are mostly nonspecific [7, 26, 29]. The intermittence of symptoms could also interfere with a correct diagnosis, if the clinical manifestations at the moment correspond to a partial obstruction or a distal migration of the gallstones. Patients usually present 4–8 days after the onset of symptoms, and diagnosis is usually made 3–8 days after the onset of symptoms [1, 2, 29, 32, 33, 34, 35, 36, 37, 38]. A high index of suspicion will be useful, particularly in an elderly patient with intestinal obstruction and previous gallstone disease; Bouveret syndrome can be suspected in a patient with gastric outlet obstruction.
\nSimple abdominal radiographs are of fundamental importance for establishing the diagnosis. In 1941, Rigler et al. [39] described four radiographic signs in the biliary ileum: (1) partial or complete intestinal obstruction; (2) pneumobilia or contrast material in the biliary tree; (3) an aberrant limestone; and (4) changing the position of such gallstones on serial film. The presence of two of the first three signs was considered pathognomonic and was found in 20–50% of cases [1, 2, 20, 37, 38, 40, 41, 42, 43, 44]. Although pathognomonic, Rigler’s triad ratios range from 0 to 87% [19]. Careful inspection for pneumobilia should be performed, as it is present in most patients with biliary ileus but is sometimes identified only in retrospective observation [20, 37, 38, 41, 42, 43]. Pneumobilia can occur following previous biliary surgery or endoscopic interventions. Therefore, clinical evaluation must be taken into account when evaluating this radiological sign [1, 2, 37, 38, 40, 41, 42, 43, 44]. In 1978, Balthazar et al. [45] described a fifth sign, which consists of two hydro-plane levels in the upper right quadrant of the abdominal radiography. The medial air fluid level corresponds to the duodenum and the lateral level to the gallbladder. These authors found that this sign was present in 24% of patients at the time of hospitalization. In Bouveret’s syndrome, a dilated stomach is expected to be seen on a simple abdominal radiograph due to gastric obstruction [37, 42, 43, 46, 47, 48, 49]. Cappell et al. [31], in a review of 64 cases of Bouveret syndrome, found pneumobilia (39%), calcified upper right quadrant mass or gallstones (38%), and gastric distension (23%) as relatively common findings and dilated loops of the intestine (14%).
\nWhen the diagnosis is still doubtful, an abdominal ultrasound (US) will be indicated for gallbladder stones, fistula, and gallstones visualization. It can also confirm the presence of choledocholithiasis [1, 2, 50]. The use of ultrasound in combination with abdominal radiography has been recommended to increase the sensitivity of the diagnosis. Ultrasound is more sensitive to the detection of pneumobilia and ectopic gallstones. The combination of abdominal and US radiography increased the sensitivity of the diagnosis of the biliary ileum to 74% [51]. The most frequent findings in Bouveret syndrome are gallstones in the gallbladder (53%), pneumobilia or gallbladder fistula (45%), gallstones in the duodenum (25%), dilated or distended stomach (15%), and a contracted gallbladder (13%) [31, 41, 43, 52, 53].
\nComputed tomography (CT) is considered superior to abdominal radiography or US in the diagnosis of biliary ileum cases, with a sensitivity of up to 93% [47, 51, 54, 55, 56, 57]. The detection frequency of Rigler’s triad is higher during the CT exam. In a retrospective study by Lassandro et al. [55, 56, 57, 58], the Rigler triad was observed in 77.8% of cases by CT, compared to 14.8% with radiographs and 11.1% with the US. Intestinal loop dilation was observed in 92.6% of cases, pneumobilia in 88.9%, ectopic gallstones in 81.5%, hydroaero levels in 37%, and bilio-digestive fistula in 14.8%. Yu et al. [54, 59] conducted a prospective study in which 165 patients with acute small bowel obstruction were evaluated for biliary ileus, with retrospective identification of three diagnostic criteria: (1) small bowel obstruction; (2) ectopic gallstones, both calcified and removed; and (3) abnormal gallbladder with complete air collection, presence of hydro-aircraft levels, or fluid accumulation with irregular wall. The overall sensitivity, specificity, and precision were 93, 100, and 99%, respectively. Rigler’s triad was detected only in 36% of cases. These tomographic diagnostic criteria require further prospective validation. Current CT scanners can describe the position of the fistula, gallstones, and gastrointestinal obstruction with greater precision helping in therapeutic decisions [37, 56, 57, 58].
\nIn an 81-case review of Bouveret syndrome [37, 43, 59, 60, 61, 62] in which esophagogastroduodenoscopy (EGD) was performed, gastroduodenal obstruction was revealed in all, but visualization of gallstones was only possible in 56 (69%). Among these 56 cases, such gallstones were observed in the duodenal bulb in 51.8%, in the postbulbar duodenum in 28.6%, in the pylorus or in the prepilorum in 17.9%, and in one case the position was not reported. Gallstones were not recognized in 31% of cases because they were deeply embedded in the mucosa. When gallstones are not displayed, the diagnosis should be strongly suspected when the observed mass is hard, convex, smooth, non-friable and non-fleshy, which are all characteristics of a biliary calculus and can improve the sensitivity of the EGD. For such cases, US and CT are the preferred noninvasive diagnostic tests to confirm endoscopic diagnosis, delineate gastroduodenal anatomy, and demonstrate a cholecystoduodenal fistula [27, 31, 52, 53, 63, 64, 65].
\nThe main therapeutic goal is the relief of intestinal obstruction by extraction of gallstones. Hydroelectrolytic imbalances and metabolic disorders due to intestinal obstruction and preexisting comorbidities are common and require management before surgery [1, 2, 14, 29, 31, 52, 53, 66, 67, 68].
\nThere is no unanimous consensus on the surgical procedure. Current surgical procedures are: (1) simple enterolithotomy; (2) enterolithotomy, cholecystectomy and closure of the fistula (one-stage procedure); and (3) enterolithotomy with cholecystectomy performed subsequently (two-stage procedure). Intestinal resection is necessary in some cases after performing the enterolithotomy.
\nEnterolithotomy was the most commonly performed surgical procedure. Through an exploratory laparotomy, the gastrointestinal obstruction site is located. A longitudinal incision is made on the antimesenteric edge proximal to the site of obstruction of the gallstones [12, 24, 66]. Whenever possible, through light manipulation, the bile stone is brought proximally to a non-edematous segment of the intestine. Most of the time, this is not possible due to the degree of impact of gallstones. Enterotomy is performed over the gallstones and extracted. Careful closure of the enterotomy is necessary to avoid narrowing of the intestinal lumen and cross-closure is recommended. Intestinal resection is sometimes required, particularly in the presence of ischemia, perforation, or underlying stenosis [12, 66]. Manual propulsion of gallstones through the ileocecal valve should be reserved for highly selected situations due to the danger of mucosal injury and intestinal perforation [12, 20, 24, 27, 28, 66]. Likewise, attempts to crush gallstones in situ can damage the intestinal wall and should be avoided [20, 27, 66, 69]. Multiple gallstones can generally be extracted through a single incision freeing the intestines and moving smaller gallstones to larger ones. In case of sigmoid obstruction, resection that removes gallstones and underlying stenosis has been recommended [12].
\nThe main long-standing controversy in biliary ileum management is whether surgery should be performed simultaneously with relief of bowel obstruction (one-stage procedure) or later (two-stage procedure).
\nIn 1922, Pybus successfully extracted a limestone blocking the ileum, closed the duodenal fistula, and drained the gallbladder after removing two additional gallstones from it. In 1929, Holz extracted a limestone at the sigmoid level, and after removing a second limestone in the duodenum, he closed the gallbladder fistula and removed the gallbladder. The author recommended this procedure for patients in satisfactory general conditions. In 1957, Welch successfully performed a one-stage surgery in a patient who was well prepared after recurrent intestinal gallstone obstruction. The authors suggested the feasibility of the operation under optimal conditions. In 1965, Berliner et al. [70] reported three similarly managed and mentioned cases that when the patient is adequately hydrated with restored serum electrolytes, it does not represent an operational risk and a one-stage surgical procedure should be considered. The authors recommend considering the one-step procedure in selected cases. The incidence of recurrence commonly cited is 2–5%, but a recurrence of up to 8% has also been reported after only enterolithotomy; half of these new onset events occurred within 30 days [71]. It should be considered that relapse rates of 17–33% have also been reported [12, 72, 73].
\nThe possibility of recurrent cholecystitis and acute cholangitis [12, 70] in patients with unrepaired gallbladder fistulas or retained gallbladder has been highlighted. Acute cholangitis has been reported in 11% of patients with cholecystoduodenal fistula and in 60% with gallbladder colic fistula [12, 52, 53, 67, 68]. With a one-stage procedure, further events related to gallstones are avoided [18].
\nA potential long-term complication of biliary enteric fistula could be gallbladder cancer. Bossart et al. [74] found an incidence of 15% of gallbladder carcinoma in 57 patients undergoing surgery for these fistulas, compared with 0.8% among all patients with cholecystectomy.
\nOn the other hand, simple enterolithotomy has long been associated with lower mortality [13]. It should be taken into account that the severity of each case affects the outcome of a particular surgical procedure and that mortality is not an absolute consequence of the surgical procedure itself. In the Clavien et al.’s [12] report, when patients were comparable in terms of age, concomitant disease, and APACHE II score, operational mortality and morbidity rates were not significantly different.
\nIn 2003, Doko et al. [75] reported a series of 30 patients with morbidity of 27.3% in patients undergoing enterolithotomy alone and 61.1% for a one-stage procedure. Mortality was 9% after enterolithotomy and 10.5% after a one-stage procedure. The American Society of Anesthesiologists (ASA) scores were similar between the two groups, but operating times were significantly longer for the one-step procedure. Urgent fistula repair was significantly associated with postoperative complications. The authors concluded that enterolithotomy is the procedure of choice, with a one-stage procedure reserved for patients with acute cholecystitis, gallbladder gangrene, or residual gallstones [12].
\nIn 2008, Riaz et al. [76] reported their retrospective experience with 10 patients diagnosed with bileous ileus. The choice of surgical procedure was largely determined by the patient’s clinical condition. Five patients underwent enterolithotomy only (group 1), while the remaining five patients underwent cholecystectomy and fistula repair (group 2). In group 1, all patients were hypertensive and diabetic. All patients were hemodynamically unstable, with metabolic acidosis and prerenal azotemia. The ASA score was III or higher in all patients. In group 2, only two patients were hypertensive and all were hemodynamically stable at presentation with an ASA score of II. There was no operational mortality in both groups.
\nMany patients with biliary ileus are elderly, with comorbidities, in poor general conditions and have a delayed diagnosis, which leads to dehydration, shock, sepsis, or peritonitis. Relief of gastrointestinal obstruction with simple enterolithotomy is the safest procedure for these patients [19, 21].
\nAt laparotomy, examination and careful palpation of the entire intestine, gallbladder, and extrahepatic bile duct is recommended in order to rule out gallstones, bile loss, abscesses, or necrosis [1, 2, 9, 14, 18, 77]. Cholecystectomy and fistula repair reduce the need for reoperation and the incidence of complications related to the persistence of the fistula, including recurrent ileus, cholecystitis, or cholangitis, but are justified only in selected patients who are adequately stabilized in good general condition, with good reserve cardiorespiratory and metabolic, and are able to withstand a more prolonged operation, unless it has been clearly demonstrated that gallstones do not remain in the gallbladder [10, 12, 21, 67, 78, 79].
\nAccording to several authors, enterolytictomy alone is the best option for most patients with biliary ileus. The one-step procedure should only be offered to highly selected patients with absolute indications for biliary surgery at the time of presentation and who have been adequately reanimated [6, 7, 13, 21, 29, 31, 52, 53, 67].
\nThe demonstration of gallstones, the appearance of symptoms, or a persistent cholecystointeric fistula indicates the need for cholecystectomy, closure of the fistula, and exploration of the common duct [18]. It has been pointed out that delayed cholecystectomy as a second procedure is clearly justified only in cases of persistence of symptoms [13, 21]. Cholecystectomy and fistula closure are recommended 4–6 weeks later [7, 13, 29, 80]. A 2.94% mortality rate has been reported in this group of patients [25].
\nThe most common postoperative complication was wound infection. In 1961, Raiford [5] observed an overall wound infection rate of 75%. Localized peritonitis, respiratory complications, phlebitis, and recurrent obstruction due to residual gallstones and cholangitis have also been observed. Wound infection continues to be the most common complication, with rates of 27 and 42.5%, as reported by Clavien et al. [12] and Rodríguez Hermosa et al. [19], respectively. Several authors have reported no significant differences in postoperative complications between patients treated with enterolithotomy or enterolithotomy, cholecystectomy, and closure of fistulas [12, 21, 67, 80]. The least common complications were wound dehiscence, cardiopulmonary and vascular complications, sepsis, intestinal and biliary fistulas, and urinary tract infections [12, 21, 80].
\nBiliary ileum is predominantly a geriatric disease and as many as 80–90% of patients have concomitant medical diseases. Hypertension, diabetes, congestive heart failure, chronic lung disease, and anemia are the most common comorbidities [25]. These associated conditions must be taken into consideration, as they can influence the results of the treatment [1].
\nMortality rates were reported up to 44% in the late 1800s, while in the first half of the twentieth century, these rates remained between 40 and 50% [14, 22]. In the 1990s, significant reductions in mortality were observed at 15–18%, at current rates of less than 7% [13, 25]. In particular, simple enterolithotomy has long been associated with a mortality of 11.7% compared to 16.9% for the one-stage procedure (enterolithotomy plus cholecystectomy and fistula closure) [13]. As described by Kirchmayr et al. [79], four main reasons could be responsible for the high number of lethal courses. First of all, the biliary ileum is a disease of the elderly. Second, concomitant diseases such as cardiorespiratory diseases and/or diabetes mellitus are frequent. Third, due to uncommon symptoms, the diagnosis is difficult and an average delay of 4 days from the start of symptoms to hospitalization is reported. Fourth, postoperative recovery is also hampered; age-related complications such as pneumonia or heart failure are more frequent than complications associated with surgery.
\nThe authors noted that fistula closure, performed during the initial procedure, was independently associated with a higher mortality rate than enterolithotomy alone. When intestinal resection was indicated, it was also associated with a higher mortality rate than with enterolithotomy alone. However, if you consider the fact that intestinal resection is not exactly an option but a requirement due to the conditions of the intestinal segment, the mortality for those patients who underwent enterolithotomy alone or intestinal resection is actually 6.53%.
\nBiliary ileum or gastrointestinal obstruction from gallstones accounts for less than 1% of cases of gastrointestinal obstruction, with a higher frequency among the elderly. Computed tomography has proven to be the most accurate diagnostic modality, but validation of diagnostic criteria is required. Surgical relief of the obstruction is the cornerstone of the treatment. Given the high incidence of comorbidity in these patients, a good judgment is needed in the choice of the surgical procedure. Enterolithotomy remains the mainstay of surgical treatment. A one-stage cholecystectomy and fistula repair are justified only in selected patients in good general condition and adequately stabilized preoperatively. Two-stage surgery is an option for patients with persistent symptoms after an enterolithotomy. Extensive prospective studies of laparoscopic and endoscopic guided procedures are planned.
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. 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His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. 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Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. 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In this chapter, the principle, sampling algorithms, scoring functions and diverse available software’s for molecular docking have been summarized. We demonstrate the interplay of docking, classical techniques of structure-based design and X-ray crystallography in the process of drug discovery. In addition, we dwell upon some of the limitations faced in docking studies. Finally, several success stories of molecular docking approaches in drug discovery have been highlighted, concluding with remarks on molecular docking for the future.",book:{id:"7867",slug:"drug-discovery-and-development-new-advances",title:"Drug Discovery and Development",fullTitle:"Drug Discovery and Development - New Advances"},signatures:"Aaftaab Sethi, Khusbhoo Joshi, K. Sasikala and Mallika Alvala",authors:[{id:"252956",title:"Dr.",name:"Mallika",middleName:null,surname:"Alvala",slug:"mallika-alvala",fullName:"Mallika Alvala"},{id:"287101",title:"Mr.",name:"Aaftaab",middleName:null,surname:"Sethi",slug:"aaftaab-sethi",fullName:"Aaftaab Sethi"},{id:"295049",title:"Ms.",name:"Khusbhoo",middleName:null,surname:"Joshi",slug:"khusbhoo-joshi",fullName:"Khusbhoo Joshi"},{id:"295050",title:"Ms.",name:"Sasikala",middleName:null,surname:"K",slug:"sasikala-k",fullName:"Sasikala K"}]},{id:"29240",doi:"10.5772/31087",title:"Oral Absorption, Intestinal Metabolism and Human Oral Bioavailability",slug:"oral-absorption-intestinal-metabolism-and-human-oral-bioavailability-",totalDownloads:27161,totalCrossrefCites:28,totalDimensionsCites:58,abstract:null,book:{id:"672",slug:"topics-on-drug-metabolism",title:"Topics on Drug Metabolism",fullTitle:"Topics on Drug Metabolism"},signatures:"Ayman El-Kattan and Manthena Varma",authors:[{id:"85539",title:"Dr.",name:"Ayman",middleName:null,surname:"El-Kattan",slug:"ayman-el-kattan",fullName:"Ayman El-Kattan"},{id:"88221",title:"Dr.",name:"Manthena",middleName:null,surname:"Varma",slug:"manthena-varma",fullName:"Manthena Varma"}]},{id:"40262",doi:"10.5772/51384",title:"Nanotechnology in Drug Delivery",slug:"nanotechnology-in-drug-delivery",totalDownloads:15405,totalCrossrefCites:11,totalDimensionsCites:53,abstract:null,book:{id:"2509",slug:"recent-advances-in-novel-drug-carrier-systems",title:"Recent Advances in Novel Drug Carrier Systems",fullTitle:"Recent Advances in Novel Drug Carrier Systems"},signatures:"Martins Ochubiojo Emeje, Ifeoma Chinwude Obidike, Ekaete Ibanga Akpabio and Sabinus Ifianyi Ofoefule",authors:[{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje"}]},{id:"65128",doi:"10.5772/intechopen.82860",title:"Natural Products in Drug Discovery",slug:"natural-products-in-drug-discovery",totalDownloads:6623,totalCrossrefCites:19,totalDimensionsCites:48,abstract:"Drug discovery using natural products is a challenging task for designing new leads. It describe the bioactive compounds derived from natural resources, its phytochemical analysis, characterization and pharmacological investigation. It focuses on the success of these resources in the process of finding and discovering new and effective drug compounds that can be useful for human resources. From many years, natural products have been acting as a source of therapeutic agents and have shown beneficial uses. Only natural product drug discovery plays an important role to develop the scientific evidence of these natural resources. Research in drug discovery needs to develop robust and viable lead molecules, which step forward from a screening hit to a drug candidate through structural elucidation and structure identification through GC–MS, NMR, IR, HPLC, and HPTLC. The development of new technologies has revolutionized the screening of natural products in discovering new drugs. Utilizing these technologies gives us an opportunity to perform research in screening new molecules using a software and database to establish natural products as a major source for drug discovery. It finally leads to lead structure discovery. Powerful new technologies are revolutionizing natural herbal drug discovery.",book:{id:"8290",slug:"pharmacognosy-medicinal-plants",title:"Pharmacognosy",fullTitle:"Pharmacognosy - Medicinal Plants"},signatures:"Akshada Amit Koparde, Rajendra Chandrashekar Doijad and Chandrakant Shripal Magdum",authors:[{id:"268668",title:"Dr.",name:"Akshada",middleName:"Amit",surname:"Koparde",slug:"akshada-koparde",fullName:"Akshada Koparde"}]}],mostDownloadedChaptersLast30Days:[{id:"49459",title:"Pharmacokinetics of Drugs Following IV Bolus, IV Infusion, and Oral Administration",slug:"pharmacokinetics-of-drugs-following-iv-bolus-iv-infusion-and-oral-administration",totalDownloads:15480,totalCrossrefCites:16,totalDimensionsCites:24,abstract:null,book:{id:"4491",slug:"basic-pharmacokinetic-concepts-and-some-clinical-applications",title:"Basic Pharmacokinetic Concepts and Some Clinical Applications",fullTitle:"Basic Pharmacokinetic Concepts and Some Clinical Applications"},signatures:"Tarek A. Ahmed",authors:[{id:"175649",title:"Dr.",name:"Tarek A",middleName:null,surname:"Ahmed",slug:"tarek-a-ahmed",fullName:"Tarek A Ahmed"}]},{id:"29240",title:"Oral Absorption, Intestinal Metabolism and Human Oral Bioavailability",slug:"oral-absorption-intestinal-metabolism-and-human-oral-bioavailability-",totalDownloads:27175,totalCrossrefCites:28,totalDimensionsCites:58,abstract:null,book:{id:"672",slug:"topics-on-drug-metabolism",title:"Topics on Drug Metabolism",fullTitle:"Topics on Drug Metabolism"},signatures:"Ayman El-Kattan and Manthena Varma",authors:[{id:"85539",title:"Dr.",name:"Ayman",middleName:null,surname:"El-Kattan",slug:"ayman-el-kattan",fullName:"Ayman El-Kattan"},{id:"88221",title:"Dr.",name:"Manthena",middleName:null,surname:"Varma",slug:"manthena-varma",fullName:"Manthena Varma"}]},{id:"66742",title:"Introductory Chapter: Alkaloids - Their Importance in Nature and for Human Life",slug:"introductory-chapter-alkaloids-their-importance-in-nature-and-for-human-life",totalDownloads:4131,totalCrossrefCites:16,totalDimensionsCites:32,abstract:null,book:{id:"6828",slug:"alkaloids-their-importance-in-nature-and-human-life",title:"Alkaloids",fullTitle:"Alkaloids - Their Importance in Nature and Human Life"},signatures:"Joanna Kurek",authors:[{id:"214632",title:"Dr.",name:"Joanna",middleName:null,surname:"Kurek",slug:"joanna-kurek",fullName:"Joanna Kurek"}]},{id:"65128",title:"Natural Products in Drug Discovery",slug:"natural-products-in-drug-discovery",totalDownloads:6637,totalCrossrefCites:19,totalDimensionsCites:48,abstract:"Drug discovery using natural products is a challenging task for designing new leads. It describe the bioactive compounds derived from natural resources, its phytochemical analysis, characterization and pharmacological investigation. It focuses on the success of these resources in the process of finding and discovering new and effective drug compounds that can be useful for human resources. From many years, natural products have been acting as a source of therapeutic agents and have shown beneficial uses. Only natural product drug discovery plays an important role to develop the scientific evidence of these natural resources. Research in drug discovery needs to develop robust and viable lead molecules, which step forward from a screening hit to a drug candidate through structural elucidation and structure identification through GC–MS, NMR, IR, HPLC, and HPTLC. The development of new technologies has revolutionized the screening of natural products in discovering new drugs. Utilizing these technologies gives us an opportunity to perform research in screening new molecules using a software and database to establish natural products as a major source for drug discovery. It finally leads to lead structure discovery. Powerful new technologies are revolutionizing natural herbal drug discovery.",book:{id:"8290",slug:"pharmacognosy-medicinal-plants",title:"Pharmacognosy",fullTitle:"Pharmacognosy - Medicinal Plants"},signatures:"Akshada Amit Koparde, Rajendra Chandrashekar Doijad and Chandrakant Shripal Magdum",authors:[{id:"268668",title:"Dr.",name:"Akshada",middleName:"Amit",surname:"Koparde",slug:"akshada-koparde",fullName:"Akshada Koparde"}]},{id:"48805",title:"Biopharmaceutics and Pharmacokinetics",slug:"biopharmaceutics-and-pharmacokinetics",totalDownloads:26159,totalCrossrefCites:2,totalDimensionsCites:7,abstract:null,book:{id:"4491",slug:"basic-pharmacokinetic-concepts-and-some-clinical-applications",title:"Basic Pharmacokinetic Concepts and Some Clinical Applications",fullTitle:"Basic Pharmacokinetic Concepts and Some Clinical Applications"},signatures:"S. Lakshmana Prabu, T.N.K. Suriyaprakash, K. Ruckmani and R.\nThirumurugan",authors:[{id:"91590",title:"Dr.",name:"Sakthivel",middleName:null,surname:"Lakshmana Prabu",slug:"sakthivel-lakshmana-prabu",fullName:"Sakthivel Lakshmana Prabu"},{id:"128690",title:"Dr.",name:"Suriyaprakash",middleName:null,surname:"Tnk",slug:"suriyaprakash-tnk",fullName:"Suriyaprakash Tnk"}]}],onlineFirstChaptersFilter:{topicId:"219",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81857",title:"Use of Oral Ketamine in Palliative Care",slug:"use-of-oral-ketamine-in-palliative-care",totalDownloads:31,totalDimensionsCites:0,doi:"10.5772/intechopen.104875",abstract:"Ketamine, an N-methyl-D-Aspartate receptor antagonist, has been used for more than 50 years. From its initial potential as an anesthetic drug, its use has increased in the fields of pain medicine, psychiatry, and palliative care. It is available in different formulations, of which oral use is promising due to its active metabolite, norketamine which reaches 2–3 times higher levels when administered orally in comparison with parenteral use. Oral use is also more feasible and easier to use in settings, where medical staff is not that present, such as home care or hospices. Oral solution of ketamine has not yet been officially licensed for use although there have been several reports which recommend its use in neuropathic pain, severe depression, airway obstruction, and anxiety. Palliative care is defined as total care for patients whose diseases do not respond to curative treatment. It encompasses good control of physical symptoms, and psychological, social and spiritual problems. Patients often experience pain, despite high doses of opioids, depression and anxiety, and dyspnea. Oral ketamine does not have the side effects of opioids therefore it represents a good alternative. It may also reduce the need for high opioid doses and be more suitable for patients who wish to avoid the necessary sedation.",book:{id:"11036",title:"Ketamine Revisited - New Insights into NMDA Inhibitors",coverURL:"https://cdn.intechopen.com/books/images_new/11036.jpg"},signatures:"Mateja Lopuh"},{id:"81722",title:"Ketamine for Chronic Pain",slug:"ketamine-for-chronic-pain",totalDownloads:20,totalDimensionsCites:0,doi:"10.5772/intechopen.104874",abstract:"The treatment of chronic pain is a chronic problem for many specialities. It is generally based on an approach with antidepressants, anti-epileptics and opioids as drugs of first choice. It has been worked by many different protocols. Ketamine, which is known as a good anaesthetic, has been used for chronic pain. When the pain has a neuropathic component, ketamine is a promising treatment for pain management. Ketamine: by inhibiting the N-methyl-D-aspartate receptor and having some other effects like enhancement of descending inhibition and anti-inflammatory effects at central sites, takes part in chronic pain management. Besides having analgesic effects, there are some concerns about the side effects of ketamine. Some psychedelic symptoms as hallucinations, memory defects, panic attacks, nausea and vomiting, somnolence, cardiovascular stimulation and sometimes hepatoxicity may be seen in patients. Ketamine is generally well-tolerated in clinical settings. Close monitoring of patients receiving ketamine should be mandatory in order to be aware of central nervous system, haemodynamic, renal and hepatic symptoms as well as abuse.",book:{id:"11036",title:"Ketamine Revisited - New Insights into NMDA Inhibitors",coverURL:"https://cdn.intechopen.com/books/images_new/11036.jpg"},signatures:"Cigdem Yildirim Guclu"},{id:"81646",title:"Cortical Plasticity under Ketamine: From Synapse to Map",slug:"cortical-plasticity-under-ketamine-from-synapse-to-map",totalDownloads:19,totalDimensionsCites:0,doi:"10.5772/intechopen.104787",abstract:"Sensory systems need to process signals in a highly dynamic way to efficiently respond to variations in the animal’s environment. For instance, several studies showed that the visual system is subject to neuroplasticity since the neurons’ firing changes according to stimulus properties. This dynamic information processing might be supported by a network reorganization. Since antidepressants influence neurotransmission, they can be used to explore synaptic plasticity sustaining cortical map reorganization. To this goal, we investigated in the primary visual cortex (V1 of mouse and cat), the impact of ketamine on neuroplasticity through changes in neuronal orientation selectivity and the functional connectivity between V1 cells, using cross correlation analyses. We found that ketamine affects cortical orientation selectivity and alters the functional connectivity within an assembly. These data clearly highlight the role of the antidepressant drugs in inducing or modeling short-term plasticity in V1 which suggests that cortical processing is optimized and adapted to the properties of the stimulus.",book:{id:"11036",title:"Ketamine Revisited - New Insights into NMDA Inhibitors",coverURL:"https://cdn.intechopen.com/books/images_new/11036.jpg"},signatures:"Ouelhazi Afef, Rudy Lussiez and Molotchnikoff Stephane"},{id:"81561",title:"Ketamine and Low-Resource Countries",slug:"ketamine-and-low-resource-countries",totalDownloads:51,totalDimensionsCites:0,doi:"10.5772/intechopen.104651",abstract:"Safe anaesthesia and surgery are piloted to reduce the morbidity and mortality associated with anaesthesia and surgery, and improve surgical outcomes. This goal is far-fetched in developing countries as a result of limited manpower, poor operation theatre infrastructure, unavailability of equipment, life-saving drugs, and anaesthetic agents. Postoperative pain is also widely undertreated in this environment, mostly due to financial constraints patients and their relatives face and the unavailability of analgesics. Sometimes the physicians face problems associated with their resource-limited working environment, such as unreliable electricity, unavailability of compressed oxygen and other gases, sophisticated machines, and modern drugs. Thus, easy adaptability and proper utilisation of available resources have been described as a resounding quality required of anaesthetists working in developing countries, to thrive and provide anaesthetic services. Ketamine is readily available in resource-limited environments, and adaptability to the use of this drug has made it possible for the anaesthetist to provide anaesthesia, pain care services, sedation, and save lives.",book:{id:"11036",title:"Ketamine Revisited - New Insights into NMDA Inhibitors",coverURL:"https://cdn.intechopen.com/books/images_new/11036.jpg"},signatures:"Chimaobi Tim Nnaji"},{id:"81236",title:"The Role of Ketamine in Trauma",slug:"the-role-of-ketamine-in-trauma",totalDownloads:52,totalDimensionsCites:0,doi:"10.5772/intechopen.103655",abstract:"Early and effective pain control in trauma patients improves outcomes and limits disability, but analgesia is often missed in the unstable patient, or hemodynamically depressing medications are avoided for fear of losing stability. This chapter outlines the role of ketamine in managing traumatic emergencies in both out-of-hospital and hospital environment, and beyond. Low-dose ketamine also called a sub-dissociative dose is safe, efficient and effective analgesic that can be considered for trauma patients, pediatric or adults, as an alternative to opioids or in combination with opioids for on additive or synergistic effect, with minimal impact on hemodynamic stability. Ketamine at higher doses is also an excellent drug for induction of anesthesia in rapid sequence induction (RSI), post-intubation sedation maintenance or procedural sedation in the trauma patient. Also, can be used for acute agitation and excited delirium. In this chapter, we are describing this drug focusing on a deeper understanding of the safety and efficacy of this agent and, if supported, to encourage physicians to consider ketamine for pain control in trauma and beyond. Also, we are presenting the current literature surrounding ketamine’s evidences in the trauma condition to establish its utility and profile of safety for these patients.",book:{id:"11036",title:"Ketamine Revisited - New Insights into NMDA Inhibitors",coverURL:"https://cdn.intechopen.com/books/images_new/11036.jpg"},signatures:"Mihai Octavian Botea and Erika Bimbo-Szuhai"},{id:"81029",title:"Uses of Ketamine in the Paediatric Population",slug:"uses-of-ketamine-in-the-paediatric-population",totalDownloads:43,totalDimensionsCites:0,doi:"10.5772/intechopen.103658",abstract:"General anesthesia in pediatric patients can vary from light sedation to complete anesthesia with unconsciousness, amnesia and muscle relaxation. A wide variety of procedures are done under general anesthesia in children ranging from surgeries done for correction of congenital defects, cardiac surgeries, scoliosis surgery, hernia surgery etc. to procedures done outside the operating room (OR) for diagnostic and therapeutic purposes. Non-Operating room Anesthesia (NORA) may include painless procedures like CT scan, MRI, radiotherapy for cancer treatment etc. or painful procedures like biopsy, lumbar puncture, securing IV access, insertion of central line etc. done in ICU which requires a cooperative child. Ketamine has an important role in the pediatric population, both as an induction agent and as a sedative-analgesic drug especially in countries where newer drugs are not readily available. Ketamine helps to alleviate separation anxiety. Even procedures done under regional techniques in some older children require use of sedation. Ketamine can be administered through various routes-IV, IM, intranasal etc. It can be used along with other groups of drugs like Benzodiazepines, Barbiturates, Alpha 2 agonists, Propofol etc. Thus Ketamine is a versatile drug with various indications for use in the pediatric population which will be discussed in the current chapter.",book:{id:"11036",title:"Ketamine Revisited - New Insights into NMDA Inhibitors",coverURL:"https://cdn.intechopen.com/books/images_new/11036.jpg"},signatures:"Bhagyalakshmi Ramesh"}],onlineFirstChaptersTotal:17},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188",scope:"This series will provide a comprehensive overview of recent research trends in various Infectious Diseases (as per the most recent Baltimore classification). Topics will include general overviews of infections, immunopathology, diagnosis, treatment, epidemiology, etiology, and current clinical recommendations for managing infectious diseases. Ongoing issues, recent advances, and future diagnostic approaches and therapeutic strategies will also be discussed. This book series will focus on various aspects and properties of infectious diseases whose deep understanding is essential for safeguarding the human race from losing resources and economies due to pathogens.",coverUrl:"https://cdn.intechopen.com/series/covers/6.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:13,editor:{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. 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He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. 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She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. 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She is also the Global Harmonization Initiative (GHI)",institutionString:"Australian College of Business & Technology",institution:{name:"Kobe College",institutionURL:null,country:{name:"Japan"}}}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. 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Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:245,paginationItems:[{id:"196707",title:"Prof.",name:"Mustafa Numan",middleName:null,surname:"Bucak",slug:"mustafa-numan-bucak",fullName:"Mustafa Numan Bucak",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/196707/images/system/196707.png",biography:"Mustafa Numan Bucak received a bachelor’s degree from the Veterinary Faculty, Ankara University, Turkey, where he also obtained a Ph.D. in Sperm Cryobiology. He is an academic staff member of the Department of Reproduction and Artificial Insemination, Selçuk University, Turkey. He manages several studies on sperms and embryos and is an editorial board member for several international journals. His studies include sperm cryobiology, in vitro fertilization, and embryo production in animals.",institutionString:"Selçuk University, Faculty of Veterinary Medicine",institution:null},{id:"90846",title:"Prof.",name:"Yusuf",middleName:null,surname:"Bozkurt",slug:"yusuf-bozkurt",fullName:"Yusuf Bozkurt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/90846/images/system/90846.jpg",biography:"Yusuf Bozkurt has a BSc, MSc, and Ph.D. from Ankara University, Turkey. He is currently a Professor of Biotechnology of Reproduction in the field of Aquaculture, İskenderun Technical University, Turkey. His research interests include reproductive biology and biotechnology with an emphasis on cryo-conservation. He is on the editorial board of several international peer-reviewed journals and has published many papers. Additionally, he has participated in many international and national congresses, seminars, and workshops with oral and poster presentations. He is an active member of many local and international organizations.",institutionString:"İskenderun Technical University",institution:{name:"İskenderun Technical University",country:{name:"Turkey"}}},{id:"61139",title:"Dr.",name:"Sergey",middleName:null,surname:"Tkachev",slug:"sergey-tkachev",fullName:"Sergey Tkachev",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61139/images/system/61139.png",biography:"Dr. Sergey Tkachev is a senior research scientist at the Institute of Fundamental Medicine and Biology, Kazan Federal University, Russia, and at the Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia. He received his Ph.D. in Molecular Biology with his thesis “Genetic variability of the tick-borne encephalitis virus in natural foci of Novosibirsk city and its suburbs.” His primary field is molecular virology with research emphasis on vector-borne viruses, especially tick-borne encephalitis virus, Kemerovo virus and Omsk hemorrhagic fever virus, rabies virus, molecular genetics, biology, and epidemiology of virus pathogens.",institutionString:"Russian Academy of Sciences",institution:{name:"Russian Academy of Sciences",country:{name:"Russia"}}},{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/310962/images/system/310962.jpg",biography:"Amlan K. Patra, FRSB, obtained a Ph.D. in Animal Nutrition from Indian Veterinary Research Institute, India, in 2002. He is currently an associate professor at West Bengal University of Animal and Fishery Sciences. He has more than twenty years of research and teaching experience. He held previous positions at the American Institute for Goat Research, The Ohio State University, Columbus, USA, and Free University of Berlin, Germany. His research focuses on animal nutrition, particularly ruminants and poultry nutrition, gastrointestinal electrophysiology, meta-analysis and modeling in nutrition, and livestock–environment interaction. He has authored around 175 articles in journals, book chapters, and proceedings. Dr. Patra serves on the editorial boards of several reputed journals.",institutionString:null,institution:{name:"West Bengal University of Animal and Fishery Sciences",country:{name:"India"}}},{id:"53998",title:"Prof.",name:"László",middleName:null,surname:"Babinszky",slug:"laszlo-babinszky",fullName:"László Babinszky",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/53998/images/system/53998.png",biography:"László Babinszky is Professor Emeritus, Department of Animal Nutrition Physiology, University of Debrecen, Hungary. He has also worked in the Department of Animal Nutrition, University of Wageningen, Netherlands; the Institute for Livestock Feeding and Nutrition (IVVO), Lelystad, Netherlands; the Agricultural University of Vienna (BOKU); the Institute for Animal Breeding and Nutrition, Austria; and the Oscar Kellner Research Institute for Animal Nutrition, Rostock, Germany. In 1992, Dr. Babinszky obtained a Ph.D. in Animal Nutrition from the University of Wageningen. His main research areas are swine and poultry nutrition. He has authored more than 300 publications (papers, book chapters) and edited four books and fourteen international conference proceedings.",institutionString:"University of Debrecen",institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"201830",title:"Dr.",name:"Fernando",middleName:"Sanchez",surname:"Davila",slug:"fernando-davila",fullName:"Fernando Davila",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201830/images/5017_n.jpg",biography:"I am a professor at UANL since 1988. My research lines are the development of reproductive techniques in small ruminants. We also conducted research on sexual and social behavior in males.\nI am Mexican and study my professional career as an engineer in agriculture and animal science at UANL. Then take a masters degree in science in Germany (Animal breeding). Take a doctorate in animal science at the UANL.",institutionString:null,institution:{name:"Universidad Autónoma de Nuevo León",country:{name:"Mexico"}}},{id:"309250",title:"Dr.",name:"Miguel",middleName:null,surname:"Quaresma",slug:"miguel-quaresma",fullName:"Miguel Quaresma",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309250/images/9059_n.jpg",biography:"Miguel Nuno Pinheiro Quaresma was born on May 26, 1974 in Dili, Timor Island. He is married with two children: a boy and a girl, and he is a resident in Vila Real, Portugal. He graduated in Veterinary Medicine in August 1998 and obtained his Ph.D. degree in Veterinary Sciences -Clinical Area in February 2015, both from the University of Trás-os-Montes e Alto Douro. He is currently enrolled in the Alternative Residency of the European College of Animal Reproduction. He works as a Senior Clinician at the Veterinary Teaching Hospital of UTAD (HVUTAD) with a role in clinical activity in the area of livestock and equine species as well as to support teaching and research in related areas. He teaches as an Invited Professor in Reproduction Medicine I and II of the Master\\'s in Veterinary Medicine degree at UTAD. Currently, he holds the position of Chairman of the Portuguese Buiatrics Association. He is a member of the Consultive Group on Production Animals of the OMV. He has 19 publications in indexed international journals (ISIS), as well as over 60 publications and oral presentations in both Portuguese and international journals and congresses.",institutionString:"University of Trás-os-Montes and Alto Douro",institution:{name:"University of Trás-os-Montes and Alto Douro",country:{name:"Portugal"}}},{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",country:{name:"Portugal"}}},{id:"283019",title:"Dr.",name:"Oudessa",middleName:null,surname:"Kerro Dego",slug:"oudessa-kerro-dego",fullName:"Oudessa Kerro Dego",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/283019/images/system/283019.png",biography:"Dr. Kerro Dego is a veterinary microbiologist with training in veterinary medicine, microbiology, and anatomic pathology. Dr. Kerro Dego is an assistant professor of dairy health in the department of animal science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. He received his D.V.M. (1997), M.S. (2002), and Ph.D. (2008) degrees in Veterinary Medicine, Animal Pathology and Veterinary Microbiology from College of Veterinary Medicine, Addis Ababa University, Ethiopia; College of Veterinary Medicine, Utrecht University, the Netherlands and Western College of Veterinary Medicine, University of Saskatchewan, Canada respectively. He did his Postdoctoral training in microbial pathogenesis (2009 - 2015) in the Department of Animal Science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. Dr. Kerro Dego’s research focuses on the prevention and control of infectious diseases of farm animals, particularly mastitis, improving dairy food safety, and mitigation of antimicrobial resistance. Dr. Kerro Dego has extensive experience in studying the pathogenesis of bacterial infections, identification of virulence factors, and vaccine development and efficacy testing against major bacterial mastitis pathogens. Dr. Kerro Dego conducted numerous controlled experimental and field vaccine efficacy studies, vaccination, and evaluation of immunological responses in several species of animals, including rodents (mice) and large animals (bovine and ovine).",institutionString:"University of Tennessee at Knoxville",institution:{name:"University of Tennessee at Knoxville",country:{name:"United States of America"}}},{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón Poggi",slug:"juan-carlos-gardon-poggi",fullName:"Juan Carlos Gardón Poggi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",biography:"Juan Carlos Gardón Poggi received University degree from the Faculty of Agrarian Science in Argentina, in 1983. Also he received Masters Degree and PhD from Córdoba University, Spain. He is currently a Professor at the Catholic University of Valencia San Vicente Mártir, at the Department of Medicine and Animal Surgery. He teaches diverse courses in the field of Animal Reproduction and he is the Director of the Veterinary Farm. He also participates in academic postgraduate activities at the Veterinary Faculty of Murcia University, Spain. His research areas include animal physiology, physiology and biotechnology of reproduction either in males or females, the study of gametes under in vitro conditions and the use of ultrasound as a complement to physiological studies and development of applied biotechnologies. Routinely, he supervises students preparing their doctoral, master thesis or final degree projects.",institutionString:null,institution:{name:"Valencia Catholic University Saint Vincent Martyr",country:{name:"Spain"}}},{id:"309529",title:"Dr.",name:"Albert",middleName:null,surname:"Rizvanov",slug:"albert-rizvanov",fullName:"Albert Rizvanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309529/images/9189_n.jpg",biography:'Albert A. Rizvanov is a Professor and Director of the Center for Precision and Regenerative Medicine at the Institute of Fundamental Medicine and Biology, Kazan Federal University (KFU), Russia. He is the Head of the Center of Excellence “Regenerative Medicine” and Vice-Director of Strategic Academic Unit \\"Translational 7P Medicine\\". Albert completed his Ph.D. at the University of Nevada, Reno, USA and Dr.Sci. at KFU. He is a corresponding member of the Tatarstan Academy of Sciences, Russian Federation. Albert is an author of more than 300 peer-reviewed journal articles and 22 patents. He has supervised 11 Ph.D. and 2 Dr.Sci. dissertations. Albert is the Head of the Dissertation Committee on Biochemistry, Microbiology, and Genetics at KFU.\nORCID https://orcid.org/0000-0002-9427-5739\nWebsite https://kpfu.ru/Albert.Rizvanov?p_lang=2',institutionString:"Kazan Federal University",institution:{name:"Kazan Federal University",country:{name:"Russia"}}},{id:"210551",title:"Dr.",name:"Arbab",middleName:null,surname:"Sikandar",slug:"arbab-sikandar",fullName:"Arbab Sikandar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210551/images/system/210551.jpg",biography:"Dr. Arbab Sikandar, PhD, M. Phil, DVM was born on April 05, 1981. He is currently working at the College of Veterinary & Animal Sciences as an Assistant Professor. He previously worked as a lecturer at the same University. \nHe is a Member/Secretory of Ethics committee (No. CVAS-9377 dated 18-04-18), Member of the QEC committee CVAS, Jhang (Regr/Gen/69/873, dated 26-10-2017), Member, Board of studies of Department of Basic Sciences (No. CVAS. 2851 Dated. 12-04-13, and No. CVAS, 9024 dated 20/11/17), Member of Academic Committee, CVAS, Jhang (No. CVAS/2004, Dated, 25-08-12), Member of the technical committee (No. CVAS/ 4085, dated 20,03, 2010 till 2016).\n\nDr. Arbab Sikandar contributed in five days hands-on-training on Histopathology at the Department of Pathology, UVAS from 12-16 June 2017. He received a Certificate of appreciation for contributions for Popularization of Science and Technology in the Society on 17-11-15. He was the resource person in the lecture series- ‘scientific writing’ at the Department of Anatomy and Histology, UVAS, Lahore on 29th October 2015. He won a full fellowship as a principal candidate for the year 2015 in the field of Agriculture, EICA, Egypt with ref. to the Notification No. 12(11) ACS/Egypt/2014 from 10 July 2015 to 25th September 2015.; he received a grant of Rs. 55000/- as research incentives from Director, Advanced Studies and Research, UVAS, Lahore upon publications of research papers in IF Journals (DR/215, dated 19-5-2014.. He obtained his PhD by winning a HEC Pakistan indigenous Scholarship, ‘Ph.D. fellowship for 5000 scholars – Phase II’ (2av1-147), 17-6/HEC/HRD/IS-II/12, November 15, 2012. \n\nDr. Sikandar is a member of numerous societies: Registered Veterinary Medical Practitioner (life member) and Registered Veterinary Medical Faculty of Pakistan Veterinary Medical Council. The Registration code of PVMC is RVMP/4298 and RVMF/ 0102.; Life member of the University of Veterinary and Animal Sciences, Lahore, Alumni Association with S# 664, dated: 6-4-12. ; Member 'Vets Care Organization Pakistan” with Reference No. VCO-605-149, dated 05-04-06. :Member 'Vet Crescent” (Society of Animal Health and Production), UVAS, Lahore.",institutionString:"University of Veterinary & Animal Science",institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}},{id:"311663",title:"Dr.",name:"Prasanna",middleName:null,surname:"Pal",slug:"prasanna-pal",fullName:"Prasanna Pal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311663/images/13261_n.jpg",biography:null,institutionString:null,institution:{name:"National Dairy Research Institute",country:{name:"India"}}},{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",country:{name:"United Kingdom"}}},{id:"283315",title:"Prof.",name:"Samir",middleName:null,surname:"El-Gendy",slug:"samir-el-gendy",fullName:"Samir El-Gendy",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRduYQAS/Profile_Picture_1606215849748",biography:"Samir El-Gendy is a Professor of anatomy and embryology at the faculty of veterinary medicine, Alexandria University, Egypt. Samir obtained his PhD in veterinary science in 2007 from the faculty of veterinary medicine, Alexandria University and has been a professor since 2017. Samir is an author on 24 articles at Scopus and 12 articles within local journals and 2 books/book chapters. His research focuses on applied anatomy, imaging techniques and computed tomography. Samir worked as a member of different local projects on E-learning and he is a board member of the African Association of Veterinary Anatomists and of anatomy societies and as an associated author at local and international journals. Orcid: https://orcid.org/0000-0002-6180-389X",institutionString:null,institution:{name:"Alexandria University",country:{name:"Egypt"}}},{id:"246149",title:"Dr.",name:"Valentina",middleName:null,surname:"Kubale",slug:"valentina-kubale",fullName:"Valentina Kubale",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246149/images/system/246149.jpg",biography:"Valentina Kubale is Associate Professor of Veterinary Medicine at the Veterinary Faculty, University of Ljubljana, Slovenia. Since graduating from the Veterinary faculty she obtained her PhD in 2007, performed collaboration with the Department of Pharmacology, University of Copenhagen, Denmark. She continued as a post-doctoral fellow at the University of Copenhagen with a Lundbeck foundation fellowship. She is the editor of three books and author/coauthor of 23 articles in peer-reviewed scientific journals, 16 book chapters, and 68 communications at scientific congresses. Since 2008 she has been the Editor Assistant for the Slovenian Veterinary Research journal. She is a member of Slovenian Biochemical Society, The Endocrine Society, European Association of Veterinary Anatomists and Society for Laboratory Animals, where she is board member.",institutionString:"University of Ljubljana",institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"258334",title:"Dr.",name:"Carlos Eduardo",middleName:null,surname:"Fonseca-Alves",slug:"carlos-eduardo-fonseca-alves",fullName:"Carlos Eduardo Fonseca-Alves",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/258334/images/system/258334.jpg",biography:"Dr. Fonseca-Alves earned his DVM from Federal University of Goias – UFG in 2008. He completed an internship in small animal internal medicine at UPIS university in 2011, earned his MSc in 2013 and PhD in 2015 both in Veterinary Medicine at Sao Paulo State University – UNESP. Dr. Fonseca-Alves currently serves as an Assistant Professor at Paulista University – UNIP teaching small animal internal medicine.",institutionString:null,institution:{name:"Universidade Paulista",country:{name:"Brazil"}}},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",biography:"María de la Luz García Pardo is an agricultural engineer from Universitat Politècnica de València, Spain. She has a Ph.D. in Animal Genetics. Currently, she is a lecturer at the Agrofood Technology Department of Miguel Hernández University, Spain. Her research is focused on genetics and reproduction in rabbits. The major goal of her research is the genetics of litter size through novel methods such as selection by the environmental sensibility of litter size, with forays into the field of animal welfare by analysing the impact on the susceptibility to diseases and stress of the does. Details of her publications can be found at https://orcid.org/0000-0001-9504-8290.",institutionString:null,institution:{name:"Miguel Hernandez University",country:{name:"Spain"}}},{id:"350704",title:"M.Sc.",name:"Camila",middleName:"Silva Costa",surname:"Ferreira",slug:"camila-ferreira",fullName:"Camila Ferreira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/350704/images/17280_n.jpg",biography:"Graduated in Veterinary Medicine at the Fluminense Federal University, specialist in Equine Reproduction at the Brazilian Veterinary Institute (IBVET) and Master in Clinical Veterinary Medicine and Animal Reproduction at the Fluminense Federal University. She has experience in analyzing zootechnical indices in dairy cattle and organizing events related to Veterinary Medicine through extension grants. I have experience in the field of diagnostic imaging and animal reproduction in veterinary medicine through monitoring and scientific initiation scholarships. I worked at the Equus Central Reproduction Equine located in Santo Antônio de Jesus – BA in the 2016/2017 breeding season. I am currently a doctoral student with a scholarship from CAPES of the Postgraduate Program in Veterinary Medicine (Pathology and Clinical Sciences) at the Federal Rural University of Rio de Janeiro (UFRRJ) with a research project with an emphasis on equine endometritis.",institutionString:null,institution:null},{id:"41319",title:"Prof.",name:"Lung-Kwang",middleName:null,surname:"Pan",slug:"lung-kwang-pan",fullName:"Lung-Kwang Pan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41319/images/84_n.jpg",biography:null,institutionString:null,institution:null},{id:"125292",title:"Dr.",name:"Katy",middleName:null,surname:"Satué Ambrojo",slug:"katy-satue-ambrojo",fullName:"Katy Satué Ambrojo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/125292/images/system/125292.jpeg",biography:"Katy Satué Ambrojo received her Veterinary Medicine degree, Master degree in Equine Technology and doctorate in Veterinary Medicine from the Faculty of Veterinary, CEU-Cardenal Herrera University in Valencia, Spain.Dr. Satué is accredited as a Private University Doctor Professor, Doctor Assistant, and Contracted Doctor by AVAP (Agència Valenciana d'Avaluació i Prospectiva) and currently, as a full professor by ANECA (since January 2022). To date, Katy has taught 22 years in the Department of Animal Medicine and Surgery at the CEU-Cardenal Herrera University in undergraduate courses in Veterinary Medicine (General Pathology, integrated into the Applied Basis of Veterinary Medicine module of the 2nd year, Clinical Equine I of 3rd year, and Equine Clinic II of 4th year). Dr. Satué research activity is in the field of Endocrinology, Hematology, Biochemistry, and Immunology in the Spanish Purebred mare. She has directed 5 Doctoral Theses and 5 Diplomas of Advanced Studies, and participated in 11 research projects as a collaborating researcher. She has written 2 books and 14 book chapters in international publishers related to the area, and 68 scientific publications in international journals. Dr. Satué has attended 63 congresses, participating with 132 communications in international congresses and 19 in national congresses related to the area. Dr. Satué is a scientific reviewer for various prestigious international journals such as Animals, American Journal of Obstetrics and Gynecology, Veterinary Clinical Pathology, Journal of Equine Veterinary Science, Reproduction in Domestic Animals, Research Veterinary Science, Brazilian Journal of Medical and Biological Research, Livestock Production Science and Theriogenology, among others. Since 2014 she has been responsible for the Clinical Analysis Laboratory of the CEU-Cardenal Herrera University Veterinary Clinical Hospital.",institutionString:null,institution:null},{id:"201721",title:"Dr.",name:"Beatrice",middleName:null,surname:"Funiciello",slug:"beatrice-funiciello",fullName:"Beatrice Funiciello",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201721/images/11089_n.jpg",biography:"Graduated from the University of Milan in 2011, my post-graduate education included CertAVP modules mainly on equines (dermatology and internal medicine) and a few on small animal (dermatology and anaesthesia) at the University of Liverpool. After a general CertAVP (2015) I gained the designated Certificate in Veterinary Dermatology (2017) after taking the synoptic examination and then applied for the RCVS ADvanced Practitioner status. After that, I completed the Postgraduate Diploma in Veterinary Professional Studies at the University of Liverpool (2018). My main area of work is cross-species veterinary dermatology.",institutionString:null,institution:null},{id:"291226",title:"Dr.",name:"Monica",middleName:null,surname:"Cassel",slug:"monica-cassel",fullName:"Monica Cassel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/291226/images/8232_n.jpg",biography:'Degree in Biological Sciences at the Federal University of Mato Grosso with scholarship for Scientific Initiation by FAPEMAT (2008/1) and CNPq (2008/2-2009/2): Project \\"Histological evidence of reproductive activity in lizards of the Manso region, Chapada dos Guimarães, Mato Grosso, Brazil\\". Master\\\'s degree in Ecology and Biodiversity Conservation at Federal University of Mato Grosso with a scholarship by CAPES/REUNI program: Project \\"Reproductive biology of Melanorivulus punctatus\\". PhD\\\'s degree in Science (Cell and Tissue Biology Area) \n at University of Sao Paulo with scholarship granted by FAPESP; Project \\"Development of morphofunctional changes in ovary of Astyanax altiparanae Garutti & Britski, 2000 (Teleostei, Characidae)\\". She has experience in Reproduction of vertebrates and Morphology, with emphasis in Cellular Biology and Histology. She is currently a teacher in the medium / technical level courses at IFMT-Alta Floresta, as well as in the Bachelor\\\'s degree in Animal Science and in the Bachelor\\\'s degree in Business.',institutionString:null,institution:null},{id:"442807",title:"Dr.",name:"Busani",middleName:null,surname:"Moyo",slug:"busani-moyo",fullName:"Busani Moyo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Gwanda State University",country:{name:"Zimbabwe"}}},{id:"439435",title:"Dr.",name:"Feda S.",middleName:null,surname:"Aljaser",slug:"feda-s.-aljaser",fullName:"Feda S. Aljaser",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"423023",title:"Dr.",name:"Yosra",middleName:null,surname:"Soltan",slug:"yosra-soltan",fullName:"Yosra Soltan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Alexandria University",country:{name:"Egypt"}}},{id:"349788",title:"Dr.",name:"Florencia Nery",middleName:null,surname:"Sompie",slug:"florencia-nery-sompie",fullName:"Florencia Nery Sompie",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sam Ratulangi University",country:{name:"Indonesia"}}},{id:"428600",title:"MSc.",name:"Adriana",middleName:null,surname:"García-Alarcón",slug:"adriana-garcia-alarcon",fullName:"Adriana García-Alarcón",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"428599",title:"MSc.",name:"Gabino",middleName:null,surname:"De La Rosa-Cruz",slug:"gabino-de-la-rosa-cruz",fullName:"Gabino De La Rosa-Cruz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"428601",title:"MSc.",name:"Juan Carlos",middleName:null,surname:"Campuzano-Caballero",slug:"juan-carlos-campuzano-caballero",fullName:"Juan Carlos Campuzano-Caballero",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}}]}},subseries:{item:{id:"95",type:"subseries",title:"Urban Planning and Environmental Management",keywords:"Circular Economy, Contingency Planning and Response to Disasters, Ecosystem Services, Integrated Urban Water Management, Nature-based Solutions, Sustainable Urban Development, Urban Green Spaces",scope:"