Non-uniformity of stress-strain state by sections of forged piece
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"2113",leadTitle:null,fullTitle:"Gas Chromatography in Plant Science, Wine Technology, Toxicology and Some Specific Applications",title:"Gas Chromatography in Plant Science, Wine Technology, Toxicology and Some Specific Applications",subtitle:null,reviewType:"peer-reviewed",abstract:"The aim of this book is to describe the fundamental aspects and details of certain gas chromatography applications in Plant Science, Wine technology, Toxicology and the other specific disciplines that are currently being researched. The very best gas chromatography experts have been chosen as authors in each area. The individual chapter has been written to be self-contained so that readers may peruse particular topics but can pursue the other chapters in the each section to gain more insight about different gas chromatography applications in the same research field. 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He started his academic career as a research assistant at Hacettepe University, Chemistry Department under supervision of Prof. Dr. Bekir Salih in 2002. From 2008-2009 he was a research scholar in the mass spectrometry research laboratories at the Chemistry Department of The University of Akron, OH. Since 2011 he has been working at Hacettepe University as a post doctoral researcher. 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Currently, it feeds about 40% of the global population and contributes 20% in terms of total calories and protein intake. According to FAO, with the addition of over 200,000 people a day to the world population, almost a billion people are suffering from hunger and 13% of the total population is currently malnourished. In developing countries, demand for wheat is expected to grow by 2.2% annually. The alarming gap between increasing demand and current production is a big challenge for scientists. To meet the challenge, we have to increase the area under production, increase yield per unit area, or both. Increasing the area seems almost impossible because of constraints like drought, salinity, water logging, and trends in urbanization. Increasing yield, on the other hand, is the potential option which is possible through adopting better management practices and advanced technologies. In this book, various advanced technologies used in wheat research are to be discussed.
\r\n\r\n\tThe book intends to deal with wheat breeding, biotechnology, improvement of wheat for biotic and abiotic stress, OMICS studies, genetic manipulation of wheat, genome editing, genome sequencing, development of better wheat plants for climate change conditions, etc.
",isbn:"978-1-80355-523-2",printIsbn:"978-1-80355-522-5",pdfIsbn:"978-1-80355-524-9",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"609fdc53674076489ba1d9cfba345c1b",bookSignature:"Dr. Mahmood-Ur-Rahman Ansari",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11359.jpg",keywords:"Wheat Production, Wheat Genetics, Wheat Biotechnology, Wheat Improvement, Biotic Stress, Abiotic Stress, Food Security, Genetic Improvement, Fungal Diseases, Insect Resistance, Climate Change, Bioinformatics",numberOfDownloads:415,numberOfWosCitations:0,numberOfCrossrefCitations:1,numberOfDimensionsCitations:2,numberOfTotalCitations:3,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 16th 2021",dateEndSecondStepPublish:"November 25th 2021",dateEndThirdStepPublish:"January 24th 2022",dateEndFourthStepPublish:"April 14th 2022",dateEndFifthStepPublish:"June 13th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"6 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:"Dr. Mahmood-ur-Rahman Ansari is a founding member of the Pakistan Society for Computational Biology (PSCB), and also a member of the International Cotton Genome Initiative (ICGI), Asian Federation of Biotechnology (AFOB), and American Society for Microbiology (ASM).",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"185476",title:"Dr.",name:"Mahmood-ur-Rahman",middleName:null,surname:"Ansari",slug:"mahmood-ur-rahman-ansari",fullName:"Mahmood-ur-Rahman Ansari",profilePictureURL:"https://mts.intechopen.com/storage/users/185476/images/system/185476.jpg",biography:"Mahmood-ur-Rahman Ansari, Ph.D., is an Associate Professor of Molecular Biology at the Department of Bioinformatics and Biotechnology, GC University – Faisalabad, Pakistan. He received his BSc (Hons) in Plant Breeding and Genetics from the University of Agriculture, Faisalabad, Pakistan, in 2003. He obtained an MPhil and Ph.D. in Molecular Biology from the National Centre of Excellence in Molecular Biology, Lahore, Pakistan, in 2006 and 2011, respectively. He has published more than eighty papers in international peer-reviewed journals in the fields of molecular biology, biotechnology, and bioinformatics. He has also published more than fifteen book chapters and edited four books. His research interest is to understand the molecular mechanisms of stress tolerance in plants. He has been involved in the genetic modification of rice and cotton, their greenhouse and field testing, as well as biosafety studies. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"46068",title:"Computer Modelling of Radial-Direct Extrusion of Porous Powder Billets",doi:"10.5772/57142",slug:"computer-modelling-of-radial-direct-extrusion-of-porous-powder-billets",body:'Improving the competitiveness of engineering products related to enhancement of extrusion technologies using computer modelling of the material behaviour that allows production of high-quality products (Aliev et al., 2001; Favrot et al., 1997, Ryabicheva, 2012).
It is well known that a wide range of complex-shaped parts with flanges and spherical cavities are applied in machine-building and operating at variable loadings and high wear conditions. This is why the mentioned parts are produced of compact materials by various types of extrusion. The extrusion techniques are less used for production parts from powder materials due to presence of residual porosity and density variation. The extrusion technologies for parts with spherical cavities producing in the automotive industry have studied insufficiently. Production of parts may be carried out using various deformation schemes by selection the optimal initial shape and porosity of billets, as well as the deformation temperature. The most common process flowsheet for parts from powder materials is the scheme involving pressing of billet (compact), sintering and subsequent final stamping to obtain the necessary accuracy and density (Ryabicheva et al., 2011).
Finite element simulation is the most effective way for determination of optimal process variables of forming operations. However, simulation of extrusion of porous billets from powder materials with taking into account dependences of mechanical properties from porosity, thermal and strain rate deforming conditions does not allow to estimate the convergence of finite element method (Awrejcewicz et al., 2004; Awrejcewicz & Pyryev, 2009). Mathematical formulation of the nonlinear coupled thermal plasticity problem makes necessary implementation of advanced solution methods for systems of linear algebraic equations (Awrejcewicz et al., 2007).
This work aims on improvement a quality of automotive parts based on a theoretical analysis of the stress-strain state, temperature fields and density distribution during radial-direct extrusion of porous powder billets.
In this chapter mathematical modelling has been conducted on the basis of plasticity theory of porous bodies and focused on sequential solving the following problems:
construction a system of differential equations of the nonlinear coupled thermal plasticity problem for three-dimensional model of billet-stamp system on the basis of the laws of plasticity theory of porous bodies with taking into account density distribution and other singularities of deformable porous body (Awrejcewicz et al., 2007; Ryabicheva & Orlova, 2012; Segal et al., 1981);
application of a finite element method for solving of nonlinear coupled thermal plasticity problem (Awrejcewicz et al., 2007, Lienhard IV & Lienhard V, 2003);
proving the stability of the finite element solution for the examined class of problems (Lienhard IV & Lienhard V, 2003; Awrejcewicz et al., 2007; Awrejcewicz & Pyryev, 2009);
formulation of the method and solving of physically nonlinear coupled thermal plasticity problem for a three-dimensional billet-stamp model of radial-direct extrusion of porous powder billets and examine the influence of temperature and deformation fields’ coupling on simulation results (Awrejcewicz et al., 2007; Awrejcewicz& Pyryev, 2009; Ryabicheva, 2012);
verification of the results of finite element simulation by experimental investigation of radial-direct extrusion of porous powder billets (Ryabicheva et al., 2012).
The plastic potential is considered as a function of stress tensor components corresponding to smooth, convex, closed surface into the stress space (Shtern et al., 1982; Ryabicheva & Orlova, 2012). This potential may be presented in the following way (Shtern, 1981; Segal et al., 1981):
where
θ - is the porosity;
m - is the parameter characterizing the degree of imperfection of the contacts in the powder billet and defining different resistance of a porous body during its testing in tension and compression. The rate of volume change resulting from the plastic deformation is presented by the expression (Shtern et al., 1982; Segal et al., 1981):
where σ0 - is the flow stress of hard phase, which is a function of accumulated deformation ω and is determined by a hardening curve of powder material at uniaxial tension.
A flow stress of hard phase may be expressed as the function
where γ - is the shape changing rate.
The value of accumulated deformation ω is renewed by solving of differential equation (Skorokhod, 1973; Shtern et al., 1982; Segal et al., 1994):
where W - is the equivalent strain rate:
The finite element method presented as a series of procedures has used for determination of distributions of stress and strain intensity, as well as density in the volume of porous billet. The first procedure is triangulation of plastically deformed body or transition from a continuum billet to its finite element counterpart. Such simulation requires implementation of extremal requirement for the functional (Shtern et al., 1982, Segal et al., 1981):
where
The first integral in (6) is the total rate of energy dissipation, the second integral - is the power of the external stresses. For a porous body, which deforms plastically, the dissipation function
where
The stress-strain state of porous powder billet and density distribution at radial direct extrusion may be calculated using dependences (1) - (7) and specific mathematical approaches with implementation of a Hilbert space (Awrejcewicz et al., 2007) and advanced solution method for a system of linear algebraic equations obtained by finite element discretization of a volume of porous powder billet (Awrejcewicz et al., 2007, Awrejcewicz & Pyryev, 2009, Ryabicheva et al., 2012).
The technology of radial direct extrusion of forged pieces from water atomized steel powder Ancorsteel® 150 HP with a spherical cavity and small flange with the ratio Dflange /Dout = 1.1 has been considered.
Temperature changes by sections of billet were determined using a heat conduction law. The analysis of interaction of contact surfaces has been conducted during each loading step, so, for elements inside of billet and in contact with tool surfaces heat conduction is determined only. The Fourier heat conduction differential equation was implemented for calculation of temperature field (Lienhard IV & Lienhard V, 2003):
where
kT - is the summary heat conduction coefficient;
C - is the specific heat capacity;
ρ - is the density of material;
T - is the temperature, K;
τ - is the loading time step.
The minimum of heat conduction functional is related to each loading step (Segal et al., 1981; Lienhard IV & Lienhard V, 2003):
The outward heat transfer between medium and surface of the billet is carrying out by convective heat transfer. The boundary conditions of the third kind have implemented on the surface of the billet (Lienhard IV & Lienhard V, 2003; Ryabicheva et al., 2012):
where
The predictor-corrector method and Arbitrary Lagrangian Eulerian (ALE) formulation were implemented for more effective solving of nonlinear coupled thermal plasticity problem and prevention of gradual distortion of mesh due to severe plastic deformations during radial-direct extrusion. The transfinite mapping method is used to create an initial mesh and remeshing (Wisselink, 2000; Stoker, 1999).
Two variants of radial direct extrusion, which are different by a shape of initial billet, have been considered. The first variant of billet is the bushing with a hole and the second is the bushing with a hole and a spherical cavity in the upper butt end. The input data for simulation: the strain rate is 0.5 m/s, deformation temperature interval is 1100 - 900 °C, friction coefficient 0.2, initial porosity of powder billet is 15 %. The dimensions of billet for extrusion by the first variant: the outer diameter Dinit is 27 mm, hole diameter 9 mm, height 31 mm, diameter of forged piece 28 mm, flange diameter 30.8 mm, height 26 mm, hole diameter 8.5 mm, die preheating temperature 200 °C. Material of stamp is die steel 5HNV GOST 5950 - 2000. The finite element model of the billet-stamp system at the beginning and the end of the extrusion is presented in Fig. 1.
Analysis of the stress-strain state and temperature field were performed in sections of billet, as shown in Fig. 2. The effective method to reduce a non-uniformity of the stress-strain state during extrusion is formation of relieving cone-shaped cavity in the initial billet (Fig. 4). According to the recommendations (Ryabicheva et al., 2011), relieving cavity for reducing of significant non-uniformity of stress-strain state in the upper end of the billet has made. The simulation scheme is presented in Fig. 3. It was assumed for simulation that the cavity depth is equal to the radius of the sphere, the cone angle was equal to 15°, 30° and 40°.
The model of the billet-stamp system: (a) - is the starting position, (b) - is the extrusion stage.
The model of initial billet – (a), section of forged piece for analysis of the stress-strain state – (b).
The model of the billet-stamp system for extrusion of billet with a relieving cavity: (a) - is the starting position, (b) - is the extrusion stage.
Drawings of initial porous powder billets are presented in Fig. 4.
Drawings of initial porous powder billets: (a) - is the billet without relieving cavity; (b) - is the billet with relieving cavity.
Finite element simulation of extrusion of forged piece from cylindrical billet with a hole has shown clearly that maximum intensities of stress and deformation observed in the surface layers of the spherical cavity by sections of forged piece OA, OB and OC. These values were decreased gradually while increasing the distance from the surface of the forged piece (Fig. 5). The maximum values of the studied variables and dramatic non-uniformity of stress-strain state have been observed in the section OC, where the highest probability of defects formation established. The intensity of stress reduced to 5.28 times while growing the distance from the surface of the forged piece, the intensity of deformation decreased to 1.6 times. At a distance of 1.8 - 2.0 mm from the surface of the cavity there is a maximum of values due to overcooling of the metal in the area of transition of spherical cavity to the hole.
Distribution of the intensity of stress and intensity of deformation during extrusion of billet with a cylindrical hole in the sections: 1 - OA; 2 - OB; 3 - OC.
Non-uniformity of stress-strain state is a significant cause of non-uniformity of the temperature field (Fig. 6). The temperature rises up to 1200 °C due to the thermal effect of plastic deformation while increasing the distance from the surface of the billet. The overcooled layer is formed at the points of contact with the forging tool due to heat transfer by conduction and convection.
The temperature field of billet at extrusion of cylindrical powder billets with a hole.
Non-uniformity of temperature field and stress-strain state of forged piece creates conditions for the formation of the fold at a distance of 2 - 3 mm from the edge of the hole, which is gradually transformed into the flow-through flaw and then leads to loss of plastic equilibrium and cracking of products. The stages of flow-through flaw defect evolution (Fig. 7, a) to the fold (Fig. 7, b, c) and crack (Fig. 7, d) have been observed. The retraction of the surface layer inside of forged piece around the flaw transforms it to the fold. Later, under pressure from a punch, the cavity of fold collapses, edges sharpening and becoming stress concentrators with following initiation and propagation of crack and formation of failure.
Evolution of flow-through flaw to a fold at extrusion of powder billets with cylindrical hole.
The stress state near the defect is significantly non-uniform (Fig. 8) and in the layers of metal adjacent to the surface of the fold, the stress intensity was about 160 - 240 MPa and the stress intensity corresponds to the lower edge of the spherical cavity surface within 180 - 250 MPa.
Estimation of stress concentration, considering the influence of temperature and strain rate conditions on properties of deformable material has provided using technical stress concentration factor aσ with taking into account the structure and plastic properties of powder material (Skorokhod, 1985; Ryabicheva, 2012):
where
Stress concentration factor on the surface of forged piece aσ = 2.5 - 3.0. After closure of the fold stress concentrator formed at its end, leading to increase in stress concentration factor aσ up to 4.0 - 6.0, resulting formation of cracks into the forged piece. This promotes the evolution of folds in a failure, and also causes deterioration of the spherical surface in the region of its transition into the inner hole. This cracking is accompanied by stress relaxation, which leads to reduction of stress down to 70 MPa after crack propagation.
The stress state during the evolution of fold to crack.
The non-uniformity coefficients of stress σinh and deformations einh were implemented for estimation the non-uniformity of stress-strain state:
where
N - is the number of finite elements inside the model.
In case of uniform deformation the values of σinh and einh are asymptotically approaching zero.
The results of analysis of non-uniformity of stress-strain state by sections of forged piece confirms that the highest non-uniformity of stress-strain state has been observed in section OC, which corresponds to retraction of surface layers of the metal during formation of flow-through flaw (Table 1).
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t
OA | \n\t\t\t0.29 | \n\t\t\t0.31 | \n\t\t
OB | \n\t\t\t0.33 | \n\t\t\t0.36 | \n\t\t
OC | \n\t\t\t0.41 | \n\t\t\t0.56 | \n\t\t
Non-uniformity of stress-strain state by sections of forged piece
Thus, conditions that are leading to formation of defects have established by numerical simulation of extrusion of the porous powder billet with a hole.
The effect of the generatrix inclination angle α, radius of sphere R and size of cone-shaped relieving cavity on the non-uniformity of stress-strain state and temperature field has been investigated. The angle α was equal to 15°, 30°, 40° and sphere\'s radius have changed from 6 to 16 mm.
As a result of implementation the relieving cavity with α = 15°, the non-uniformity of stress-strain state decreased, in compare with extrusion of billet without the cavity, but was not completely eliminated (Fig. 9). The maximum stress intensities in the surface layers of the spherical cavity of forged piece for all three sections have found (Fig. 9, a). The intensity of stress decreases at increasing of the distance from the cavity surface, especially in the most dangerous section OC down to 52 MPa. Intensity of deformation maximized at the distance of 1.9 - 2.4 mm from the surface, indicating the risk of flow-through flaw formation, and then also decreased (Fig. 9, b).
In this case, the intensity of stress and deformation values during extrusion of billet with generatrix inclination angle of relieving cavity 15° are lower than without it.
The distribution of the intensity of stress and intensity of deformation during extrusion of billet with relieving cavity (α = 15°): 1 - is the section OA; 2 - is the section OB; 3 - is the section OC.
Thus, implementation of compacts with the relieving cavity and α =15° was not ensured decreasing of non-uniformity of stress-strain state to an appropriate level. Consequently, in the transition region of spherical cavity in the hole during the final extrusion step a flaw is formed, but was not developed into a fold as the result of decreasing the non-uniformity of stress-strain state.
Increasing the angle α up to 30° reduces non-uniformity of stress-strain state on 30 %. The largest and smallest σi and ei differ by 1.7 times and 2.1 times, respectively (Fig. 10). Parameters of stress-strain state are distributed more uniformly by sections. Consequently, a flow-through flaw was not formed in forged pieces during extrusion.
The results of analysis of non-uniformity of stress-strain state by sections of forged piece during extrusion of billets with relieving cavity at α = 15° and α = 30° are presented in Table 2.
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t||
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t|
OA | \n\t\t\t0.25 | \n\t\t\t0.15 | \n\t\t\t0.13 | \n\t\t\t0.17 | \n\t\t
OB | \n\t\t\t0.28 | \n\t\t\t0.10 | \n\t\t\t0.14 | \n\t\t\t0.12 | \n\t\t
OC | \n\t\t\t0.33 | \n\t\t\t0.13 | \n\t\t\t0.23 | \n\t\t\t0.15 | \n\t\t
Evaluation of non-uniformity of stress-strain state at various values of the inclination angle of relieving cavity generatrix
The non-uniformity of stress-strain state in the sections OB and OC decreases with increasing of inclination angle of the relieving cavity generatrix that improving quality of forged piece, but does not completely eliminates defects. Further reduction of non-uniformity of stress-strain state by increasing the angle α was confirmed by simulation of radial direct extrusion of billets with spherical cavity at inclination angle α = 5 - 45° and radius of sphere R = 6 - 16 mm.
The distribution of the intensity of stress – (a) and deformation – (b) during extrusion of billets with relieving cavity (α = 30°): 1 - is the section OA; 2 - is the section OB; 3 - is the section OC.
Dependences of the intensity of stress by layers of powder material for various radii of spherical cavity R and different values of angle α are presented on Fig. 11 according to the modelling results.
Dependences of maximum intensity of stress from the angle α and radius R: 1 - R = 16 mm; 2 - R = 14 mm; 3 - R = 12 mm; 4 - R = 10 mm; 5 - R = 8 mm; 6 - R = 6 mm.
Analysis of dependences has shown that intensity of stress reaches a minimum at α = 30 - 40°. The angle α is close to 40° at increasing of R, and angle α is close to 30° while decreasing of R. This means that the range of permissible values of angle α is within 30 - 40°.
Thus, to obtain the most uniform stress-strain state during radial-direct extrusion of forged pieces at Dflange/Dout = 1.1, the billet with relieving cavity (Fig. 4, b) and α = 30 - 40° may be recommended.
To verify the validity of this conclusion the distribution of stress-strain state parameters at α = 40° in three sections of forged piece are presented on Fig. 12. Retrieved reduction of non-uniformity of stress-strain state by 6-10% at extrusion, according to (9), has compared with extrusion at α = 30°.
The distribution of the intensity of stress and intensity of deformation at extrusion of billets with relieving cavity (α = 40°): 1 - is the section OA; 2 - is the section OB; 3 - is the section OC.
The maximal values of the intensity of deformations are lower and shifted to deeper layers of forged piece at 2.3 - 4.0 mm. The results of the non-uniformity analysis of stress-strain state by sections of forged piece with relieving cavity angle α = 40° are presented in Table 3. The non-uniformity of stress-strain states is lower for all three sections, in compare with extrusion at α = 30°.
Therefore, extrusion of porous powder billets with relieving cavity having a generatrix inclination angle within 30 - 40° provides a uniform stress-strain state.
Improvement of the uniformity of stress-strain state by using billets with relieving cavity allows obtaining a more uniform temperature field by the section of forged piece (Fig. 13).
Thus, the comparative analysis of the radial-direct extrusion of cylindrical billets with generatrix inclination angle α within 30 - 40° has shown that the presence of relieving cavity increases the uniformity of the temperature field and stress-strain state. This helps to reduce the stress intensity and stress concentration factor kσ at the edges of the cavity by 3 - 4 times.
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t
OA | \n\t\t\t0.08 | \n\t\t\t0.01 | \n\t\t
OB | \n\t\t\t0.06 | \n\t\t\t0.01 | \n\t\t
OC | \n\t\t\t0.08 | \n\t\t\t0.03 | \n\t\t
Evaluation of non-uniformity of stress-strain state at the generatrix inclination angle α = 40°
As a result, the probability of flow-through flaw formation and risk of crack propagation during extrusion have diminished rapidly.
Analysis of the density changing by the volume of forged piece was simulated for extrusion of billet with the initial porosity 15 %, outer diameter Dout = 27 mm and diameter of hole 9 mm. The density variation and equidensity at different conditions of radial direct extrusion of forged piece have been investigated.
The temperature field of the billet at extrusion of billet with relieving cavity at α = 40°.
The most difficult is to ensure equidensity at extrusion of flange of forged piece due to tensile stresses. Therefore, density distribution is presented by section OA (Fig. 14) where the highest probability of defects formation occurs.
The maximum density of 7.77 g/cm3 during extrusion of billets without relieving cavity at ratio Dflange/Dout 1.1 - 1.3 (Fig. 14, a) was reached in the volume of metal adjacent to the surface of forged piece at Dflange/Dout = 1.1 that does not corresponding to the density of compact material. This is due to the increase of tensile stress, leading to a tightening of the surface layer of the metal forging deeper. Moreover, the greater a flange, the more decrease in density of metal adjacent to the surface of sphere and in the flange. A density close to 7.83 g/cm3 has obtained in the billet at α = 15° only at the ratio Dflange/Dout = 1.1 (Fig. 14, b).
In two other cases, it decreases by the volume of flange, but with a smaller gradient. A high density obtained for Dflange/Dout = 1.1 - 1.2 at different initial density while increasing angle α to 30° (Fig. 14, c). However, if Dflange / Dout = 1.3 the density of compact material obtained. The high density has obtained at the cavity angle α = 40° for Dflange/Dout = 1.1 - 1.2 (Fig. 13, d). It is rather difficult to change the volume of forged piece at any density for Dflange/Dout = 1.3. Pores and cracks were appeared on spherical surface of the metal due to increased loosening at radial flow of metal in the gap and on the side of flange.
Density distribution by the section OA of forged piece (a) - with no relieving cavity; (b, c, d) - with the relieving cavity (generatrix inclination angle α is 15, 30, 40°, respectively): 1 - Dflange / Dout = 1.1; 2 - Dflange / Dout =1.2; 3 - Dflange / Dout = 1.3.
Simulation of the density distribution at Dflange/Dout = 1.3 during extrusion of billets with 10 % initial porosity and inclination angle of relieving cavity generatrix 40° shown the density variation within 7.79 - 7.81 g/cm3 that indicates a possibility to obtain the equidence and high-strength details.
One of the most important problems during development of metal forming technologies for powder billets is determination of deforming force that is necessary for reasonable choice of pressing equipment. The analytical expression of extrusion force P in polar coordinates for known average intensity of stress σiave on the contact surface of upper punch and powder billet or function for σi may be written in the following way (Wagoner & Chenot, 2001):
where F - is the area of contact surface of upper punch and powder billet.
The expression (13) for radial-direct extrusion of forged piece with spherical cavity and central hole with accounting the modelling results may be transformed to:
where Dflange - is the outer diameter of flange;
Dhole - is the diameter of hole.
Values of extrusion force calculated by formula (14) at different inclination angles of generatrix of relieving cavity for Dflange/Dout = 1.1 and height of the cavity 6 mm are presented in the Table 4.
The dependence of extrusion force from the relative flange size is presented in the Table 5 (α = 40°, diameter of sphere Dsf = 20 mm).
P, kN | \n||
0 | \n\t133.1 | \n\t92.0 | \n
15 | \n\t118.2 | \n\t81.7 | \n
30 | \n\t103.7 | \n\t71.6 | \n
40 | \n\t84.5 | \n\t58.4 | \n
Extrusion force at different inclination angles of generatrix of relieving cavity for Dflange/Dout = 1.1
Dflange/Dout\n\t\t | \n\t\tP, kN | \n|
1.1 | \n\t84.5 | \n\t58.4 | \n
1.2 | \n\t106.2 | \n\t89.6 | \n
1.3 | \n\t127.4 | \n\t124.5 | \n
The extrusion force at different flange size,
The results of computer modelling and laboratory experiments are well concordant with relative error 7 - 9 %.
In this chapter the results of computer modelling of radial direct extrusion of forged piece with the spherical cavity and small flange from a cylindrical billet with a porosity of 15 % and axial hole have shown a high non-uniformity of the stress-strain state, temperature field and density distribution by sections of forged piece that leads to appearing of defects are reported. It has been shown, among other, how the smallest non-uniformity of the stress-strain state, temperature field and maximum density indicate a possibility to obtain high-quality products.
A high-quality details with a spherical cavity and the ratio Dflange /Dout = 1.2 may be obtained from powder billets with 15 % initial porosity and relieving cavity with generatrix inclination angle 40°. Details with the ratio Dflange / Dout = 1.3 may not be produced from such billets due to the presence of cracks and non-uniformity into the flange. High-quality details with the ratio Dflange/Dout = 1.3 may be made from billets of 10 % initial porosity and relieving cavity with generatrix inclination angle within 30 - 40°.
The highest density of 7.80 - 7.83 g/cm3 and the equidensity of flange observed in forged pieces at the ratio Dflange/Dout = 1.1 - 1.2, obtained from billets with generatrix inclination angle of relieving cavity within 30 - 40° and initial porosity of 15 %. Forged pieces with Dflange/Dout = 1.3 and density 7.79 - 7.81 g/cm3 may be produced from powder billets with generatrix inclination angle of relieving cavity within 30 - 40° and 10 % initial porosity.
The simulation and experimental results are well concordant with relative error 7 - 9 %.
The discipline of “Forest Utilization” in Japan was introduced with reference to the German “Forstbenutzung” at the end of the nineteenth century. The Forstbenutzung covers not only the processes of felling, processing, yarding/skidding, and transporting trees but also wood anatomy, wood physics, wood processing, and wood craft; therefore, it can be said that the Forstbenutzung pursues the rational utilization of forests and trees. In the case of Japan, the research subjects of wood anatomy, wood physics, wood processing, and wood craft went independent as the Wood Science after World War II; thus, the Forest Utilization has progressed to cover the fields of civil engineering, machine engineering, operational efficiency, and ergonomics in forestry. From this point of view, the current Japanese Forest Utilization is similar to the Forest Engineering developed in North America and the Forest Operations developed in Europe.
Research and development (R&D) in the Forest Utilization is very important to make the Japanese forestry economically viable. Now, the stumpage price, i.e., the price of standing trees per m3,
where
where
In this chapter, with the aim of showing the R&D of forest biomass production and its utilization within the framework of the Japanese Forest Utilization, the current situation of forests and forestry as well as woody biomass utilization in Japan is described, and the future outlook for the use of forest biomass in Japan is presented.
The current total forest area in Japan is about 25 million ha. As shown in Table 1, in densely populated countries such as the USA, Canada, and Germany, slightly more than 30% of national land area is covered with forest [1]. Japan has a population size similar to the abovementioned countries; however, forest occupies almost two-thirds of the national land, which is the same level as in sparsely populated Sweden and Finland. This can be attributed to the steepness of so much of the land area in Japan.
Region | Country | Land area [A] | Forest area [B] | B/A | Population |
---|---|---|---|---|---|
(x 1,000 ha) | (x 1,000 ha) | (%) | (x 1,000) | ||
Asia | Japan | 36,450 | 24,958 | 68.5 | 126,573 |
North America | USA | 916,192 | 310,095 | 33.8 | 321,774 |
Canada | 909,351 | 347,069 | 38.2 | 35,940 | |
Central Europe | Germany | 34,861 | 11,419 | 32.8 | 80,689 |
Austria | 8,244 | 3,869 | 46.9 | 8,545 | |
Northern Europe | Sweden | 41,034 | 28,073 | 68.4 | 9,779 |
Finland | 30,390 | 22,218 | 73.1 | 5,503 |
Comparison of land area, forest area, and population.
Figure 1 shows the changes in the breakdown of the Japanese forest area [2]. The total forest area has been constant for more than a half century. Historically, naturally regenerated forests were converted to planted forests. During and after World War II, quite large numbers of trees were felled and harvested, so afforestation was actively promoted from the 1950s to the 1970s in order to compensate. Ten million hectares of man-made planted forests, which equals almost 30% of the total national land area, was established in the 1980s.
Changes in the breakdown of the Japanese forest area.
On the other hand, after World War II, the more the Japanese economy grew, the worse the profitability of forestry became. Young people left rural areas, and then the self-sufficiency rate of wood decreased continuously. Thus, the incentive for afforestation was gradually diminished. As shown in Figure 2, consequently, the current age distribution of planted forest is extremely imbalanced, so that 65% of planted forests that are older than 45 years reach the time for being harvested finally [2].
Age distribution of planted forest (as of March 2017).
Figure 3 shows the changes in the growing stock [2]. The growing stock keeps increasing mainly because of the dominance of young planted forests. The current average stem volume per 1 ha of planted forest, 324 m3/ha, is similar to that of Austrian forests, 325 m3/ha. This means that an operational efficiency equivalent to that of Austria might be expected if the forest infrastructure was well developed and the logging system was fully mechanized, but in practice, this is very difficult to achieve.
Changes in the growing stock.
The changes in the wood supply and demand are shown in Figure 4 [2]. As mentioned previously, the self-sufficiency rate continuously decreased in inverse proportion to the economic growth during the latter half of the twentieth century. The trade in roundwood was completely liberalized in 1964, more than a half century ago. Since the middle of the 1990s, Japan has been in an economic slump, so the demand for wood is shrinking. On the other hand, planted forests are maturing, and thus, the supply of domestic wood is gradually increasing and the self-sufficiency rate itself is improving, the driving force for which will be explained later.
Changes in the wood supply and demand.
Figure 5 shows the number of workers that can be employed by 1 m3 of standing Japanese cedar trees [3]. The number of workers is calculated by dividing the stumpage price of standing Japanese cedar trees by the daily wage of a forestry worker. It can be read from the graph that, even in Japan, labor-intensive work was possible during the 1960s.
Number of workers that can be employed by 1 m3 of standing Japanese cedar trees.
The changes in the number of forestry workers are shown in Figure 6 [2]. The number of forestry workers decreased by more than 100,000 in the past 35 years, and the percentage of aged workers (>65 years old) is relatively higher than that in other industries in Japan. On the other hand, forestry is the only industry in Japan in which the percentage of young workers (<35 years old) is increasing. The replacement of manual labor by mechanization in the limbing, bucking, and yarding/forwarding processes, but not in the felling process, seems to be contributing to this.
Changes in the number of forestry workers.
Figure 7 illustrates a typical mechanized logging system in Japan. The system is similar to that of Austrian mountainous areas. Nearly 10,000 advanced forestry machines such as processors, tower yarders, and forwarders have been introduced, and 70% of the logs produced are processed by such forestry machines. However, there are not enough forest roads, so supplemental lower-grade operation roads have been constructed, and a forwarder uses them to haul logs to a forest road.
Typical mechanized logging system in Japan.
A comparison of productivity and logging costs is given in Table 2 [4]. In Japan, the rate of operation of advanced forestry machines remains at a low level, which makes the productivity low and the logging cost high. It is said that, in Austria, intensive investments were made in the development of a forest road network in the 1960s, when the price of wood was relatively higher. Although the price of wood fell and the labor cost rose after that, the productivity was improved by mechanization. The forest road network density in Japan, 19.7 m/ha (13.1 m/ha for forest roads and 6.6 m/ha for operation roads), is less than a quarter of that in Austria, 89 m/ha (45 m/ha for forest roads and 44 m/ha for operation roads). The development of a forest road network is relatively delayed in Japan.
Country | Productivity (m3/man-day) | Logging cost (USD/m3) |
---|---|---|
Japan (final cutting) | 4.00 | 57.7 |
Japan (thinning) | 3.45 | 84.8 |
Sweden | 30 | 11.8 (final cutting) 21.8 (thinning) |
Austria | 7–43 | 29.1–50.0 |
Comparison of productivity and logging costs.
After the Kyoto Protocol was adopted in 1997, renewable and carbon-neutral biomass attracted widespread attention for its potential as an ideal primary energy resource in a sustainable society. In 2001, the Japanese government officially defined biomass as one of the new energy resources in the “Law Concerning Special Measures for Promotion of the Use of New Energy” [5], and the government decided on the “Biomass Nippon Strategy” in 2002 [6]. As mentioned previously, forest resources are abundant in Japan, and thus, the energy utilization of woody biomass is expected to contribute to a revitalization of the forestry and forest products industries, which have long been depressed. The annual available amount of woody biomass resources is estimated to be 31.7 million dry-t/y [7], which has a calorific value of 634 PJ/y, corresponding to 2.8% of the national primary energy supply, 23.0 EJ/y, and woody biomass utilization was expected to promote the tending of planted forests, many of which were being neglected when the Biomass Nippon Strategy was adopted. This triggered the energy and material utilization of waste woody biomass such as mill residues (Figure 8), wood-based waste materials (Figure 9), and tree trimmings.
Mill residue.
Wood-based waste material.
With respect to the actual situation of planted forests at that time, the thinning of largely established planted forests did not commonly take place because the trees were so small that there was little profitability on a business basis in thinning operations.
Figure 10 shows a comparison of the woody bioenergy utilization around 2005. From the point of view of the amount of woody bioenergy utilization itself, Japan was almost on a par with Sweden and Finland. This is because there has been a big pulp and paper industry in Japan, and the recycling of black liquor, that is, by-product from the kraft process when digesting pulpwood into paper pulp removing lignin, hemicelluloses, and other extractives from the wood to free the cellulose fibers, was promoted in the 1970s.
Comparison of the woody bioenergy utilization around 2005 (Each percentage value means the share to the total domestic primary energy supply).
The domestic woody biomass availability in 2010 as estimated by the Japanese government is shown in Figure 11 [8]. There was little available waste woody biomass such as mill residue or wood-based waste material, while logging residue went almost unutilized. It has been said since that time that logging residues should be utilized by developing dedicated harvesting machines as has been done in Sweden and Finland.
Domestic woody biomass availability in 2010.
In these statistics, the term “logging residue” actually refers to unutilized thinning materials (Figure 12). In view of environmental conservation and global warming mitigation measures, huge amounts of subsidies were spent to fell trees for the purpose of thinning, but the felled trees were never harvested. Thus, the young planted forests contained large amounts of felled thinnings. So, the 20 million m3/y of logging residue shown in Figure 11 should have been classified as “forest biomass,” most of which was composed of unutilized thinnings.
Young planted forest contained large amounts of felled thinnings.
The Feed-in Tariff scheme for renewable energy (FIT) was launched in 2012, 1 year after the Fukushima nuclear disaster following the Great East Japan Earthquake, and the scheme increased the utilization of forest biomass. Figure 13shows the framework of the FIT [9]. In the case of biomass, the electric utilities have committed to buy the electricity derived from biomass at a higher price than the normal retail one for 20 years. However, this cost is passed down to the electricity consumers. Japanese public covered additional 18.8 billion US dollars in 2016 within the framework of the FIT. The price of electricity has already risen over 10% from the price before the implementation of the FIT.
Framework of the FIT.
With respect to the woody biomass resources for the FIT, “general wood” consists of mill residues and imported woods. From the point of view of power generation capacity, the construction project of a power generation plant which utilizes general wood as fuel accounts for the majority (Figure 14) [10]. There are plans to establish many large-scale plants with a power-generation capacity of more than 10 MW along seashores and to import a huge amount of woody biomass such as wood chips, wood pellets, and palm kernel shells (PKS).
Map of FIT-certified woody biomass power plants.
Forest biomass utilization is also being done mainly in mountainous areas. The main source of forest biomass is the unutilized thinnings that were once abandoned in planted forests (Figure 15). Since the tariff on electricity derived from forest biomass is set to be hefty, the price of forest biomass as fuel is sometimes greater than that of forest biomass as pulpwood. In some areas, pulpwoods are also transported directly to power generation plants, and adjacent pulp mills located in such areas are obliged to import pulpwoods instead.
Unutilized thinnings that were once abandoned in planted forests.
As a result, forest biomass utilization is rapidly increasing (Figure 16) [2]. The rapid increase in the utilized amount of forest biomass triggered by the FIT is the driving force behind the improvement of the self-sufficiency rate of wood. The self-sufficiency rate of wood in 2017 as shown in Figure 4 was 36.2%, but it goes down to 31.6% when the use of wood as fuelwood is excluded.
Changes in the utilized amount of forest biomass.
It is unclear whether unutilized thinnings can continue to be utilized as energy in the future. Planted forests are going to mature so that the value of the thinning material will increase and the amount available for energy use will decrease. On the other hand, “true” logging residues such as tree tops and limbs are not currently utilized much as energy sources. If this situation continues, the energy utilization of forest biomass might drop sharply after the completion of the FIT. Thus, a framework for the utilization of logging residues must be established as soon as possible.
The use of the whole-tree logging system has increased through the spread of mechanization, such as the use of processors and harvesters. This situation makes logging residues easier to collect. So an efficient and low-cost harvesting, transporting, and chipping system for logging residues must be established. The author’s research group experimented with the collection of logging residues by a forwarder (Figure 17) [11]. Comminution of logging residues was also investigated (Figure 18) [12], and the harvesting (collecting and comminuting) cost of logging residues was calculated as 76.0 USD/dry-t [13]. As compared to Sweden and Finland, where the energy utilization of forest biomass is making steady progress (see Figure 10), the calculated cost is relatively expensive, so that the development of dedicated machines such as the chipper-forwarder (Figure 19) [14] and bundler (Figure 20) [15] may be necessary [16].
Experimenting with a forwarder hauling of slashes.
Comminution of logging residues with a tub grinder.
Chipper-forwarder.
Bundler.
The use of small-sized trees is also promising. The area covered by planted forests that have undergone final cutting and subsequent reforestation is now gradually increasing. Thus, a cleaning operation in young planted forests will be necessary 15–20 years from now, when the FIT will expire. So the development of efficient harvesting technology for small-sized trees will be necessary. An accumulative felling machine (Figure 21) may be effective [17, 18]. Harvesting small-sized trees with a truck-mounted multi-tree felling head was attempted (Figure 22), and the harvesting (felling, collecting, and comminuting) cost of small-sized trees was calculated as 99.4 USD/dry-t.
Multi-tree feller-buncher.
Harvesting small-sized trees with a truck-mounted multi-tree felling head.
Short rotation woody coppices (SRWC) have a huge potential. Before and during World War II, an average of 50 million m3/y of naturally regenerated forest was felled and harvested for energy use in the form of charcoal and firewood in Japan. The annual available amount of naturally regenerated broad-leaved trees used as SRWC is estimated to be 9 million dry-t/y [7]. The energy utilization of SRWC has already begun within the framework of the FIT. Moreover, the development of short rotation forestry in abandoned farmlands may be worth considering. Commercial willow plantations have been cultivated for bioenergy purposes in Sweden since the 1980s, and around 16,000 ha of short rotation willow plantations were established domestically from 1986 to 2000 [19]. In 2006, about 8,000 ha of the first commercial willow biomass crops in North America were started in upstate New York [20]. Growing and harvesting willow trees aimed at short rotation forestry was experimented with in northern Japan. A sugarcane harvester that was used in southern Japan was applied for harvesting willows during its agricultural off-season (Figure 23) [21]. The harvesting (growing, cutting, collecting, and comminuting) cost of SRWC was calculated as 136 USD/dry-t [22].
Experiment of harvesting willow trees using a sugarcane harvester.
In this chapter, the current situation of forests and forestry as well as woody biomass utilization in Japan was described, and the future outlook for the use of forest biomass in Japan was presented. As a result, the following conclusions were drawn:
Many planted forests are now becoming mature, so the operational efficiency in forestry should be improved not only by the development of the forest infrastructure but also by the full mechanization of the logging system;
The Kyoto Protocol adopted in 1997 promoted the energy utilization of waste woody biomass such as mill residues and wood-based waste materials, and then the launch of the FIT in 2012 promoted the energy utilization of once-unutilized thinnings;
In order to further expand the production of forest biomass and its utilization for energy, logging residues, small-sized trees, and SRWC are promising. Thus, low-cost harvesting technologies should be developed as soon as possible, with reference to machines and systems operating in foreign countries where the utilization of such forest biomass is making steady progress.
This chapter was financially supported in part by JSPS KAKENHI Grant Number JP20K06121.
The author declares no conflict of interest.
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In vitro, chemicals such as drugs and pesticides have different cytotoxicity mechanisms such as destruction of cell membranes, prevention of protein synthesis, irreversible binding to receptors etc. In order to determine the cell death caused by these damages, there is a need for cheap, reliable and reproducible short-term cytotoxicity and cell viability assays. Cytotoxicity and cell viability assays are based on various cell functions. A broad spectrum of cytotoxicity assays is currently used in the fields of toxicology and pharmacology. There are different classifications for these assays: (i) dye exclusion assays; (ii) colorimetric assays; (iii) fluorometric assays; and (iv) luminometric assays. Choosing the appropriate method among these assays is important for obtaining accurate and reliable results. When selecting the cytotoxicity and cell viability assays to be used in the study, different parameters have to be considered such as the availability in the laboratory where the study is to be performed, test compounds, detection mechanism, specificity, and sensitivity. In this chapter, information will be given about in vitro cytotoxicity and viability assays, these assays will be classified and their advantages and disadvantages will be emphasized. The aim of this chapter is to guide the researcher interested in this subject to select the appropriate assay for their study.",book:{id:"6310",slug:"genotoxicity-a-predictable-risk-to-our-actual-world",title:"Genotoxicity",fullTitle:"Genotoxicity - A Predictable Risk to Our Actual World"},signatures:"Özlem Sultan Aslantürk",authors:[{id:"211212",title:"Dr.",name:"Özlem Sultan",middleName:null,surname:"Aslantürk",slug:"ozlem-sultan-aslanturk",fullName:"Özlem Sultan Aslantürk"}]},{id:"66259",doi:"10.5772/intechopen.85270",title:"Antioxidant Compounds and Their Antioxidant Mechanism",slug:"antioxidant-compounds-and-their-antioxidant-mechanism",totalDownloads:7403,totalCrossrefCites:49,totalDimensionsCites:125,abstract:"An antioxidant is a substance that at low concentrations delays or prevents oxidation of a substrate. Antioxidant compounds act through several chemical mechanisms: hydrogen atom transfer (HAT), single electron transfer (SET), and the ability to chelate transition metals. 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Among these heavy metals, a few have direct or indirect impact on the human body. Some of these heavy metals such as copper, cobalt, iron, nickel, magnesium, molybdenum, chromium, selenium, manganese and zinc have functional roles which are essential for various diverse physiological and biochemical activities in the body. However, some of these heavy metals in high doses can be harmful to the body while others such as cadmium, mercury, lead, chromium, silver, and arsenic in minute quantities have delirious effects in the body causing acute and chronic toxicities in humans. The focus of this chapter is to describe the various mechanism of intoxication of some selected heavy metals in humans along with their health effects. Therefore it aims to highlight on biochemical mechanisms of heavy metal intoxication which involves binding to proteins and enzymes, altering their activity and causing damage. 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Antioxidant compounds act through several chemical mechanisms: hydrogen atom transfer (HAT), single electron transfer (SET), and the ability to chelate transition metals. The importance of antioxidant mechanisms is to understand the biological meaning of antioxidants, their possible uses, their production by organic synthesis or biotechnological methods, or for the standardization of the determination of antioxidant activity. In general, antioxidant molecules can react either by multiple mechanisms or by a predominant mechanism. The chemical structure of the antioxidant substance allows understanding of the antioxidant reaction mechanism. This chapter reviews the in vitro antioxidant reaction mechanisms of organic compounds polyphenols, carotenoids, and vitamins C against free radicals (FR) and prooxidant compounds under diverse conditions, as well as the most commonly used methods to evaluate the antioxidant activity of these compounds according to the mechanism involved in the reaction with free radicals and the methods of in vitro antioxidant evaluation that are used frequently depending on the reaction mechanism of the antioxidant.",book:{id:"8008",slug:"antioxidants",title:"Antioxidants",fullTitle:"Antioxidants"},signatures:"Norma Francenia Santos-Sánchez, Raúl Salas-Coronado, Claudia Villanueva-Cañongo and Beatriz Hernández-Carlos",authors:[{id:"143354",title:"Dr.",name:"Raúl",middleName:null,surname:"Salas-Coronado",slug:"raul-salas-coronado",fullName:"Raúl Salas-Coronado"},{id:"148546",title:"Dr.",name:"Norma Francenia",middleName:null,surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez"},{id:"193718",title:"Dr.",name:"Beatriz",middleName:null,surname:"Hernández-Carlos",slug:"beatriz-hernandez-carlos",fullName:"Beatriz Hernández-Carlos"},{id:"278133",title:"Dr.",name:"Claudia",middleName:null,surname:"Villanueva-Cañongo",slug:"claudia-villanueva-canongo",fullName:"Claudia Villanueva-Cañongo"}]},{id:"66742",title:"Introductory Chapter: Alkaloids - Their Importance in Nature and for Human Life",slug:"introductory-chapter-alkaloids-their-importance-in-nature-and-for-human-life",totalDownloads:3960,totalCrossrefCites:14,totalDimensionsCites:29,abstract:null,book:{id:"6828",slug:"alkaloids-their-importance-in-nature-and-human-life",title:"Alkaloids",fullTitle:"Alkaloids - Their Importance in Nature and Human Life"},signatures:"Joanna Kurek",authors:[{id:"214632",title:"Dr.",name:"Joanna",middleName:null,surname:"Kurek",slug:"joanna-kurek",fullName:"Joanna Kurek"}]}],onlineFirstChaptersFilter:{topicId:"19",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81382",title:"Therapeutic Inhibitors: Natural Product Options through Computer-Aided Drug Design",slug:"therapeutic-inhibitors-natural-product-options-through-computer-aided-drug-design",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.104412",abstract:"Drug repurposing involves reusing an active pharmaceutical ingredient that is already in the market and drugs that were unsuccessful in their clinical phases of development for a new indication. It has numerous benefits in drug development. Therapeutic inhibitors are agents that could be of synthetic or natural source with the ability to trigger the down-regulation of an enzyme or protein, thereby inducing therapeutic effect(s). Researchers have embraced synthetic methods in searching for therapeutic molecules through structural activity relationships and other means in the past and recent times. Despite these synthetic drugs, the morbidity and mortality rate of ailment and disease affecting humanity remains overwhelming. Research has shown that solutions to these challenges can be attempted through drug repurposing. In the past, natural products in raw forms have been utilized in traditional, complementary medicine to manage and treat diseases and illnesses, as there are molecules in use today as drugs, which originated from plants and other natural sources. Studies on natural products have led to diverse natural product databases that can serve as a source of repurposing agents. There are also databases for protein and enzymes of human origin, which have an enormous role in the in-silico drug repurposing approach.",book:{id:"10881",title:"Drug Repurposing - Molecular Aspects and Therapeutic Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10881.jpg"},signatures:"InnocentMary IfedibaluChukwu Ejiofor, Christabel Chikodili Ekeomodi, Sharon Elomeme and MaryGeraldine Ebele Ejiofor"},{id:"81857",title:"Use of Oral Ketamine in Palliative Care",slug:"use-of-oral-ketamine-in-palliative-care",totalDownloads:10,totalDimensionsCites:0,doi:"10.5772/intechopen.104875",abstract:"Ketamine, an N-methyl-D-Aspartate receptor antagonist, has been used for more than 50 years. From its initial potential as an anesthetic drug, its use has increased in the fields of pain medicine, psychiatry, and palliative care. It is available in different formulations, of which oral use is promising due to its active metabolite, norketamine which reaches 2–3 times higher levels when administered orally in comparison with parenteral use. Oral use is also more feasible and easier to use in settings, where medical staff is not that present, such as home care or hospices. Oral solution of ketamine has not yet been officially licensed for use although there have been several reports which recommend its use in neuropathic pain, severe depression, airway obstruction, and anxiety. Palliative care is defined as total care for patients whose diseases do not respond to curative treatment. It encompasses good control of physical symptoms, and psychological, social and spiritual problems. Patients often experience pain, despite high doses of opioids, depression and anxiety, and dyspnea. Oral ketamine does not have the side effects of opioids therefore it represents a good alternative. It may also reduce the need for high opioid doses and be more suitable for patients who wish to avoid the necessary sedation.",book:{id:"11036",title:"Ketamine Revisited - New Insights into NMDA Inhibitors",coverURL:"https://cdn.intechopen.com/books/images_new/11036.jpg"},signatures:"Mateja Lopuh"},{id:"81811",title:"Environmental Pollution Originated by the Excessive Use of Agrochemicals in the Production of Granadilla (Passiflora ligularis) Oxapampa District, Pasco, Perú",slug:"environmental-pollution-originated-by-the-excessive-use-of-agrochemicals-in-the-production-of-granad",totalDownloads:7,totalDimensionsCites:0,doi:"10.5772/intechopen.104910",abstract:"The purpose of this research was to evaluate the environmental pollution originated by the excessive use of agrochemicals in the production of granadilla (Passiflora ligularis) in the Oxapampa district, Pasco – Peru. The crops of this fruit were chosen in the sectors named: Abra (Ab), Chacos (Ch), Quillazú (Qll), Acuzazú (Ac), Cañera (Ca), San Alberto (SA), Alto Río Pisco (ARP), and Paradise (Pa), where applying the nonexperimental and comparative design, the soil, water, and fruit samples were taken, which were analyzed in the specialized laboratory of the Faculty of Chemistry and Chemical Engineering, of the Universidad Nacional Mayor de San Marcos (UNMSM). A survey was also carried out by the farmers to form groups (ABC), and the results obtained were statistically analyzed by means of the comparative difference of concentration of heavy metals in three groups selected according to intensity of use of agrochemicals, which were between 0.26 and 0.36 mg of Cu/kg of fruit, between 0.001 and 0.003 mg of Cd and Pb/kg of fruit, between 0.0012 and 0.0006 mg As and Hg/kg of fruit, between 19 and 25 mg of Cu/kg of soil, between 0.02 and 0.08 mg of Cd and Pb/kg of soil, between 0.05 and 0.08 mg of As and Hg/kg of soil; between 1 and 1.12 mg of Cu/l of water, between 0.002 and 0.003 mg of Cd and Pb/l of water, between 0.002 and 0.005 mg of As and Hg/l of water; being observed high averages in some heavy metals and whose comparisons were not significant for As, Hg, Pb, Cd, Cu in fruits, soil, and water, and significant only the Cd in fruits and Hg in soils, concluding that there is a potential risk of toxicity due to ingestion of granadilla (P. ligularis).",book:{id:"11329",title:"The Toxicity of Environmental Pollutants",coverURL:"https://cdn.intechopen.com/books/images_new/11329.jpg"},signatures:"Benito Buendía Quispe and Raymundo Erazo Erazo"},{id:"81818",title:"Radiopharmaceutical Biodistribution and Dosimetry",slug:"radiopharmaceutical-biodistribution-and-dosimetry",totalDownloads:17,totalDimensionsCites:0,doi:"10.5772/intechopen.104917",abstract:"Nuclear medicine is a medical specialty, where diagnostic and or therapeutic radioisotopes are used to study the physiology of organs and the metabolism of various types of tumors. Pharmaceuticals labeled with radionuclides (radiopharmaceuticals) are studied at pre-clinical level before being used in humans. Animals (Rodents) are generally used to study the biokinetics of tracer in a group of predefined organs. The extrapolation of the results of these studies from animals to humans provides an estimate of the behavior of the radiopharmaceuticals and the irradiation delivered clinically. Nuclear Medicine is fundamentally based on Radiopharmaceuticals whose biodistribution in disease and healthy organ result in either images that are diagnostically useful or local irradiation of tissue that is therapeutically beneficial for treatment of tumors. In result, in most procedures the biodistribution is primarily dependent on clearance of the radiopharmaceuticals from the blood into organs, tissues or lesions. Radiation is harmful for living beings and hence radiation toxicity is required to assess for new radiopharmaceutical which can be calculated by following the methodology of Internal dose calculation. Basic principle of Internal dosimetry and calculation methodology are explained in this chapter.",book:{id:"11012",title:"Radiopharmaceuticals - Current Research for Better Diagnosis and Therapy",coverURL:"https://cdn.intechopen.com/books/images_new/11012.jpg"},signatures:"Santosh Kumar Gupta and Venkatesh Rangarajan"},{id:"81739",title:"Machine Learning and Artificial Intelligence in Therapeutics and Drug Development Life Cycle",slug:"machine-learning-and-artificial-intelligence-in-therapeutics-and-drug-development-life-cycle",totalDownloads:16,totalDimensionsCites:0,doi:"10.5772/intechopen.104753",abstract:"In recent years, the pharmaceutical business has seen a considerable increase in data digitization. With digitization, however, comes the challenge of obtaining, analyzing, and applying knowledge to solve complex clinical problems. Artificial intelligence (AI), which entails a variety of advanced tools and networks that can mimic human intellect, can overcome such challenges with traditional pharmaceutical development. Artificial intelligence and machine learning have a vast role in therapeutic development, including the prediction of drug target and properties of small molecules. By predicting the 3D protein structure, AI techniques, such as Alpha Fold, can help with structure-based drug development. Machine learning algorithms have been utilized to anticipate the properties of small molecules based on their chemical structure. Many researches have shown the importance of using in silico predictive ADMET (absorption, distribution, metabolism, excretion, and toxicity) models to speed up the discovery of small compounds with enhanced efficacy, safety, and dosage. This chapter discusses various roles of these methods in the development of effective therapeutics.",book:{id:"11091",title:"Drug Development Life Cycle",coverURL:"https://cdn.intechopen.com/books/images_new/11091.jpg"},signatures:"Subhomoi Borkotoky, Amit Joshi, Vikas Kaushik and Anupam Nath Jha"},{id:"81722",title:"Ketamine for Chronic Pain",slug:"ketamine-for-chronic-pain",totalDownloads:14,totalDimensionsCites:0,doi:"10.5772/intechopen.104874",abstract:"The treatment of chronic pain is a chronic problem for many specialities. It is generally based on an approach with antidepressants, anti-epileptics and opioids as drugs of first choice. It has been worked by many different protocols. Ketamine, which is known as a good anaesthetic, has been used for chronic pain. When the pain has a neuropathic component, ketamine is a promising treatment for pain management. Ketamine: by inhibiting the N-methyl-D-aspartate receptor and having some other effects like enhancement of descending inhibition and anti-inflammatory effects at central sites, takes part in chronic pain management. Besides having analgesic effects, there are some concerns about the side effects of ketamine. Some psychedelic symptoms as hallucinations, memory defects, panic attacks, nausea and vomiting, somnolence, cardiovascular stimulation and sometimes hepatoxicity may be seen in patients. Ketamine is generally well-tolerated in clinical settings. Close monitoring of patients receiving ketamine should be mandatory in order to be aware of central nervous system, haemodynamic, renal and hepatic symptoms as well as abuse.",book:{id:"11036",title:"Ketamine Revisited - New Insights into NMDA Inhibitors",coverURL:"https://cdn.intechopen.com/books/images_new/11036.jpg"},signatures:"Cigdem Yildirim Guclu"}],onlineFirstChaptersTotal:80},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:99,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:290,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:12,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). 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Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:249,paginationItems:[{id:"274452",title:"Dr.",name:"Yousif",middleName:"Mohamed",surname:"Abdallah",slug:"yousif-abdallah",fullName:"Yousif Abdallah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274452/images/8324_n.jpg",biography:"I certainly enjoyed my experience in Radiotherapy and Nuclear Medicine, particularly it has been in different institutions and hospitals with different Medical Cultures and allocated resources. Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. His research interests include optimization, computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, and intelligent systems. Prof. Sarfraz has been a keynote/invited speaker at various platforms around the globe. He has advised/supervised more than 110 students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He has authored and/or edited around seventy books. Prof. Sarfraz is a member of various professional societies. He is a chair and member of international advisory committees and organizing committees of numerous international conferences. He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}},{id:"147824",title:"Mr.",name:"Pablo",middleName:null,surname:"Revuelta Sanz",slug:"pablo-revuelta-sanz",fullName:"Pablo Revuelta Sanz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"5",type:"subseries",title:"Parasitic Infectious Diseases",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology",scope:"Parasitic diseases have evolved alongside their human hosts. 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