Material properties of solar stills.
\r\n\t1. Emphasizing the unique power of the molecular docking method in new drug discovery;
\r\n\t2. Demonstration of how the molecular docking technique has led to the discovery of new molecules in cancer therapy, proteasome, and STAT3 inhibition, and the treatment of Alzheimer's disease;
\r\n\t3. Underlining the importance of molecular docking-based modeling methods in the various branches of biotechnology
\r\n\tWe hope that this book will be a common point where researchers working in the fields of life sciences and drug development will eventually meet.
",isbn:"978-1-80356-468-5",printIsbn:"978-1-80356-467-8",pdfIsbn:"978-1-80356-469-2",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"8c918a1973786c7059752b28601f1329",bookSignature:"Dr. Erman Salih Istifli",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11451.jpg",keywords:"Protein-Ligand Interaction, Lead Discovery, Molecular Recognition, Enzyme-Ligand Interaction, Mutant Enzymes, Alanine Screening, Proteasome Inhibitors, Signal Transducers, Transcription Activators (STATs), DNA Recognition Motifs, Neoplastic Cells, Amyloid-Beta Proteins",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 3rd 2022",dateEndSecondStepPublish:"May 4th 2022",dateEndThirdStepPublish:"July 3rd 2022",dateEndFourthStepPublish:"September 21st 2022",dateEndFifthStepPublish:"November 20th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"A multidisciplinary researcher working in the fields of cytogenetics, molecular genetics, and bioinformatics-based molecular modeling (currently on the structural biology of COVID-19 and the treatment of Alzheimer’s disease). Dr. Istifli previously joined the molecular cytogenetics group at the Max Planck Institute for Molecular Genetics in Berlin, Germany where he contributed experimentally to the identification of four candidate genes (GRIA2, GLRB, NPY1R, and NPY5R).",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"179007",title:"Dr.",name:"Erman Salih",middleName:null,surname:"Istifli",slug:"erman-salih-istifli",fullName:"Erman Salih Istifli",profilePictureURL:"https://mts.intechopen.com/storage/users/179007/images/system/179007.JPG",biography:"Dr. Erman Salih İstifli received his Ph.D. from Biology Department of Cukurova University, Insitute of Science and Letter. In his doctoral study, Dr. İstifli focused on the elucidation of the genotoxic and cytotoxic effects of a commonly used anticancer agent (antifolate) on human lymphocytes. During his period of doctoral research, he joined the molecular cytogenetics group at the Max Planck Institute for Molecular Genetics in Berlin, Germany, and he focused there on investigating the molecular cytogenetic causes of some human rare diseases. During these studies, he contributed experimentally to the identification of four candidate genes (GRIA2, GLRB, NPY1R, and NPY5R) responsible for intelligence and obesity. He was assigned as an expert and rapporteur on eight candidate projects in the Marie-Sklodowska Curie-Actions Innovative Training Networks in 2016. In 2017, he completed the online theoretical and practical course 'Introduction to Biology - The Secret of Life', run by the Massachusetts Institute of Technology (MIT) on the edX platform. In April 2019, within the framework of Erasmus+ staff mobility program, he gave seminars on 'DNA microarrays and their use in genotoxicity' at Tirana University in Tirana, Albania. He is a published author of several articles in journals covered by the SCI and SCI-E, and has manuscripts in other refereed scientific journals. He currently serves as a referee in several journals covered by the SCI and SCI-E. His studies mainly fall into the field of genetic toxicology. He continues his current research on the structural biology of COVID-19 as well as identification of novel plant-based hit compounds in the treatment of Alzheimer’s disease.",institutionString:"Çukurova University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Cukurova University",institutionURL:null,country:{name:"Turkey"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"11",title:"Engineering",slug:"engineering"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"280415",firstName:"Josip",lastName:"Knapic",middleName:null,title:"Mr.",imageUrl:"https://mts.intechopen.com/storage/users/280415/images/8050_n.jpg",email:"josip@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copy-editing and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"8068",title:"Cytotoxicity",subtitle:"Definition, Identification, and Cytotoxic Compounds",isOpenForSubmission:!1,hash:"20a09223d92829b5478b5f241f6a03ce",slug:"cytotoxicity-definition-identification-and-cytotoxic-compounds",bookSignature:"Erman Salih Istifli and Hasan Basri Ila",coverURL:"https://cdn.intechopen.com/books/images_new/8068.jpg",editedByType:"Edited by",editors:[{id:"179007",title:"Dr.",name:"Erman Salih",surname:"Istifli",slug:"erman-salih-istifli",fullName:"Erman Salih Istifli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6969",title:"Lymphocytes",subtitle:null,isOpenForSubmission:!1,hash:"1aa8ac01c934ebdeedd5d7813036beef",slug:"lymphocytes",bookSignature:"Erman Salih Istifli and Hasan Basri İla",coverURL:"https://cdn.intechopen.com/books/images_new/6969.jpg",editedByType:"Edited by",editors:[{id:"179007",title:"Dr.",name:"Erman Salih",surname:"Istifli",slug:"erman-salih-istifli",fullName:"Erman Salih Istifli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10198",title:"Response Surface Methodology in Engineering Science",subtitle:null,isOpenForSubmission:!1,hash:"1942bec30d40572f519327ca7a6d7aae",slug:"response-surface-methodology-in-engineering-science",bookSignature:"Palanikumar Kayaroganam",coverURL:"https://cdn.intechopen.com/books/images_new/10198.jpg",editedByType:"Edited by",editors:[{id:"321730",title:"Prof.",name:"Palanikumar",surname:"Kayaroganam",slug:"palanikumar-kayaroganam",fullName:"Palanikumar Kayaroganam"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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They are a first and in many cases -superior alternative to classic excision lifts, implants etc. Author\'s contribution is that his closed approach suture techniques can be used in areas, where access is difficult or impossible for other surgeries; they lift SMAS and fascias without traditional incisions; cheekbone augmentation and lifting is possible without implants and transplants. Operations are ambulatory, with excellent results, as reported by the patients. Trauma is minimal and the follow-up period is not longer than a few hours to 3 days with fast, sometimes immediate return to work and social life. There are no visible scars, only needle perforations on the skin, which disappear within 2-3 days. The techniques consist of passing closed sutures, by needle perforations only, to lift movable fascias and fix them to non-movable skeletal structures in several mid-facial areas.
Scarless, closed approach Serdev Suture® techniques for augmentation and lifting of cheekbones were introduced by the author in 1994. They use the
There were no known specific surgical methods for simultaneous direct cheekbone lifting, enhancement and volumising without the use of implants or transplants before 1994. The superficial muscle-aponeurotic system, or SMAS, was described by Mitz and Peyronie in 1976 and the SMAS facelift became the gold standard. Earlier procedures developed into a large rotation-advancement skin flap for indirect lifting of this area. Classic rhytidectomy progressed into sub-fascial, tri-plane, deep-plane, composite, subperiosteal, multiplane, “en-bloc” and other extended surgical methods, with a progressively increasing rate of complications and downtime. Nowadays, minor operations with reduced risks and faster recovery time have become more common, but the SMAS lifts without undermining remain the best long-term suspension, affecting the overlying skin. Later techniques, such as barbed “thread lifts”, are placed subdermally and naturally cannot include the SMAS in the lift. They are free floating, not sutured, nor stabilized by attachment to immobile anatomical structures. Therefore, in the author’s opinion, they are different from suture lifts and cannot guarantee a safe prolonged outcome.
Anesthesia
Only local anaesthesia, or in combination with i.v. sedation, is used. It is preferable to general anaesthesia, due to the benefits of decreased intervention time and for preferences expressed by the surgeon and patient.
Anatomical guidelines
A
A
The temporoparietal tendon is attached to and above the spina suprameatica of the meatus acusticus externus. Its insertions, together with the underlying periosteum are stable, immobile and in rare cases are used by the author for mid-face lift.
The SMAS has a fascial extension, attached to the zygoma (called zygomatic SMAS exptension), which can move up and down, permitting facial movement and flaccidity. The author captures and stretches this mobile extension in a temporoparietal direction, thus lifting the mid and lower face SMAS.
The cheekbone lift, using a transcutaneous closed suture approach, without excision of skin, was created initially (1990-1993) due to an increasing demand by young (as well as elderly) patients, who declined classic scarring lifts, associated with a month-lasting recovery, and also by people who could not afford to skip their work for a long time. Exploring topographic anatomy, designing new instruments and semi-elastic sutures allowed the author to lift loose SMAS and fat pads, using patients’ own fascial structures, and attach them to stable, immobile anatomical structures, zygomatic periosteum and in rare cases – to temporoparietal tendon insertion and underlying periosteum, or upper temporal line periosteum with temporal fascia. To achieve the objective of scarless lifting, the author uses needle perforations only. In order to attach the different subdermal fascial layers, he has created special curved, semi-blunt and semi-elastic needles with different lengths. For the cheekbone lift, 50 mm, 60 mm, 100 mm or 140 mm Serdev® needles are used. They can introduce long-term absorbable (in 2-3 years), semi-elastic Polycon USP 2 surgical sutures, for suturing the fat pad fascial tube and attaching it to the stable zygomatic periosteum. Suture selection is the surgeon’s responsibility; nevertheless, a proper diameter semi-elastic surgical suture is recommended to obtain long-term results. Sutures with a diameter of 3/0 and 2/0 are too thin for the middle and lower face heaviness and act like a scalpel (cutting through the tissues) and fail to securely immobilize facial tissue. They are not acceptable or appropriate for satisfactory and stable results.
Curved, semi-blunt and semi-elastic needles, with lengths of 50 mm, 60 mm, 100 mm and 140 mm and hollow tip.
Long-term absorbable (in 2-3 years), semi-elastic, braided, antimicrobial Bulgarian polycaproamide (Polycon) USP 2 surgical sutures for suture cheekbone lift.
For any of the cheekbone lifts described below, the author uses 2 or 3 skin perforations to introduce the needle and place the suture at the desired anatomical level.
The skin perforation point A can be positioned differently in young and in elderly patients, in order to obtain a secure attachment of the suture to the zygoma periosteum or the temporoparietal tendon insertion and periosteum below, or the upper temporal line and temporal fascia, or the border of the orbit.
The main suture fixation is to zygoma periosteum. There is a limitation for perforation of the zygoma periosteum in the “danger area” – the first 3 cm in front of the tragus.
Skin Perforation Point A can be located along the length of the zygoma, except in the danger area - the first 3 cm in front of the tragus. Perforation point B is located about 3 mm laterally to the nasolabial fold. This allows the nasolabial fold to be stretched and flattened. Point B could be planned at any point along the length of the nasolabial fold, from the nasolabial angle up to the oral commissure and smiling point. The smiling dimple location is at the intersection of the following lines: 1. The line, connecting the oral commissure and the tragus; 2. The lateral canthus line.
Point A can be located along the length of the zygoma, except in the danger area, which is the first 3 cm anterior to the tragus and should not be used to attach the sutures.
Point B is located about 3 mm lateral to the nasolabial fold. This allows the nasolabial fold to be stretched and flattened. It can be placed at any point along the length of the nasolabial fold – from the nasolabial angle to the oral commissure and smiling point. The smiling point is located at the intersection of lines: 1. connecting the oral commissure and the tragus and 2. the lateral canthus line.
Video: http://www.youtube.com/watch?v=jbi3hHxUdcw
A semi-blunt, curved 50 mm or 60 mm Serdev® needle is introduced at point A at the lateral canthus line, 1 cm below the lateral canthus on the cheekbone prominence; the pass is first made subperiosteally, engaging the anterior zygoma periosteum.
The suture is then introduced in the needle eye and the first suture end is pulled out through line A-B (Fig.6).
Medial cheekbone lift in cephalic direction solves emptiness below the eyes in Asians, hollow eyes, tear through fold, gives volume, projects and lifts cheekbone medially (important in Asians). Soft tissue amount inside the suture provides cheekbone volume and prominence.
Transmucosal cheekbone lift. Protection of needle and suture contamination using plastic cannula from a needle cap.
After local anesthesia, skin perforations are made, using a No. 11 scalpel blade. A 60 mm Serdev® needle is introduced through point A, biting into the anterior zygoma periosteum, then continuing directly to point B, deep into the cheek SMAS. The needle passes through
the buccal fat pad fascial tube, point B, and is treaded. Then, it is introduced through the first (deep) needle pass A-B.
Second (more superficial) pass A-B\n\t\t\t\tThe second needle pass A-B is more superficial (again directed from A to B).
In point B, the needle is threaded and the second suture end is introduced in the more superficial needle pass A-B. The suture circle is completed. Both suture ends at point A and the skin perforation B are pulled in opposite directions to remove any skin dimpling. Remove any dimpling at perforation point A as well
Medial cheekbone lifting in cephalic direction resolves the flat emptiness below the eyes in Asians, hollow eyes, tear trough folds; adds volume, projects and lifts the cheekbone medially. The amount of soft tissue inside the suture provides cheekbone volume and prominence, without implants and transplants. In Asians the procedures for medial cheekbone lift can remarkably reduce lateral bulging of the zygoma, soften the facial oval and give a Caucasian type appearance.
Medial cheekbone lift to fulfill the emptiness below the eyes. Better definition of the beauty triangle.
Medial cheekbone lift. Higher cheekbones and better definition of the beauty triangle
Before and after simultaneous cheekbone SMAS lift and chin enhancement by suture to obtain the “beauty triangle”. Lifting of muscle-cheek SMAS flap, using 2 perforation points in a 49 y.o. patient.
Cheekbone augmentation and lifting.
Medial cheekbone lift in a 45 y.o. patient to fulfill the tear trough fold, lift and volumize the cheekbones. Better definition of the beauty triangle
Medial cheekbone lift in an Asian patient,
The technique is the same as the one described above, in 2 variants: lifting of muscle-cheek SMAS flap or facial tube of buccal fat pad. In both variations, the zygomatic SMAS extension is also included in the lift. The older and more flabby the patient, the lower the point B. It is advisable to include Bichat’s fat pad fascial tube in the suture in both variants. This is a very rarely used modification, only in cases where higher fixation is needed, usually in cases with smaller lower face proportion and mostly in open surgery, combined with blepharoplasy. For cases of facial disproportions in the lower face and especially in microgenia and retrogenia, the author has in his hands the suture method to elongate and enhance the chin (see Fig. 14 and Serdev Sutures® in Lower Face) that is a better technique to adapt proportions.
Skin perforation point A is located at lower, anterior sideburn hairline angle. Using 1 or 2 perforation points B. A) In elderly patients two B points are used to collect more soft tissue and to obtain the lateral cheekbone projection. Pass A-A1 is subperiosteal. A1 is only a mark, not a skin perforation point. All the B perforation points are 3mm lateral to the nasolabial fold. The dotted A-B1 line is located in deep soft tissue, below the lower lid. The dotted B1-B2 line is located inside the fascial tube of Bichat’s fat pad. B) If only one perforation point B is used, points B1 and B2 are only marks (not perforated).
The older and more flacid the patient, the lower point B should be located. Bichat’s fat pad fascial tube should be included in the suture. At the lower part of the nasolabial fold, perforation point B can be made through the skin or the oral mucosa. This suture presents: Combined traction on SMAS zygomatic extension and fat pad fascias; Collection of all the cheekbone soft tissue.
First Pass A-(A1)-(B2)-B – deep in the tissue flap (see Fig.15)Variation 1 - Perforation point B through the skin: a 140 mm Serdev® needle is introduced in point A, at the lower anterior sideburn hairline angle; at the start the pass is subperiosteal, biting anterior zygoma periosteum (line A-A1). Point A1 is only a mark, not a perforation point.The needle is introduced through point A, without catching periosteum, and continues in a medium deep level above the zygoma to the lateral canthus line (line A-A). If a dimple appears on the skin surface above the needle position, it means that the needle is located too superficially and should be repositioned deeper. At the lateral canthus line, the needle changes direction below the lower lid and perforates the fascial tube of Bichat’s fat pad at its upper point B1 (B1 is only a mark). Then, the needle direction is changed (while still inside the fat pad fascial tube) and exits at perforation point B (through the skin or trans-mucosal). The second suture end is threaded and pulled out through the needle pass A-B (A-(A)-(B1)-B). This completes the suture circle, attaching the buccal fat pad fascia to the zygomatic periosteum. A knot is tied under medium tension (suturing too tightly damages the tissue). The vector is in a temporoparietal direction. The zygomatic SMAS extension is engaged in the suture. This corrects the tear trough fold, gives optimum volume while projecting and lifting the lateral cheekbone. The soft tissue inside the suture gives cheekbone volume and prominence, without using implants or transplants. Dimpling at perforation point B is released by pulling the skin at this point with a mosquito clamp and the suture ends at A in opposite directions. Eventual dimpling at point A should be removed as well.
2. Fixation at posterior zygoma. Using 3 perforation points. Perforation Point A is at sideburn lower anterior hairline angle. Point B1 at nasolabial angle, Point B2 at lower nasolabial fold or at smiling point. Perforation point B2 could be through skin or oral mucosa.The surgical technique is the same as the one described above.
The author uses skin or mucosal perforation point B1, and skin or mucosal perforation point B2.
The pass between the B1 and B2 must be located in the fat pat fascial tube (Fig. 16). Otherwise, traction will occur on unstable fat and soft tissue.
Using trans-mucosal perforation points: When perforation points B1 and B2 are trans-mucosal (intra-nasal at nasolabial angle or in oral mucosa at lower nasolabial fold area and smiling point), needle and suture should be protected using a cannula (Fig. 7). All collected soft tissue included in the suture is tractioned in temporoparietal direction. Skin and tissue impressions at perforation points should be managed using a mosquito clamp.Cheeks will be augmented laterally, which is recommendable mostly in Caucasians. Vice versa, Asians have laterally projected cheekbones but their faces are more flat medially and hollow below their eyes. In Asians, the author recommends medial cheekbone enhancement.
Pass between perforation point B1 and B2 is located inside of fat pad fascial tube.
Lateral cheekbone lift. Fixation at posterior zygoma. Combined traction on SMAS zygomatic extension and fat pad fascias using 3 perforation points with trans-nasal, trans-mucosal perforation point B1, and trans-dermal B2;
Lateral cheekbone lift. Fixation at posterior zygoma. Using 3 perforation points. Combined traction on SMAS zygomatic extension and fat pad fascias.
Medial cheekbone lift. Fixation to anterior zygoma, using 2 perforation points.
Medial cheekbone lift to eliminate the tear through fold. Fixation to anterior zygoma, using 2 perforation points.
Formation of cheek dimple at smiling point is easy, engaging dermis in the suture at skin perforation point B, located at the smiling point (Fig 21).
Cheekbone lift with cheek dimple. Using 2 points in an elderly patient.
Traction on dermis at smiling point, which forms cheek dimple. Using 2 points in an elderly patient.
1280 patients with suture cheekbone lifts were followed from 3 to 18 years. The procedures took place during the period between 1993 and December 2012 to enhance, lift and improve the checkbones, as well as to solve problems of an ageing face, such as nasolabial folds, tear trough folds, marionette folds, hollow area, skin wrinkling etc. 92% of these patients had simultaneous suture lifts and other treatments of face or body. In the face, the author combines the cheekbone lift mostly with temporal lift, brow lift, lower SMAS-platysma lift, chin enhancement and beautification rhinoplasties. Early and late results are mostly satisfactory to excellent. Patient satisfaction, apart from consideration of rejuvenation and beautification outcomes, is mostly connected to local anesthesia, absence of pain, short operation time, immediate or very rapid recovery and fast return to social activities and work. Patients’ aesthetic satisfaction goes beyond pre-operative expectations. In the first 7-10 days an expected sensation of tension in the operated area is present, which is normal. In fact, most patients love this “lifting sensation” and describe it as pleasant and expected.
In 1 patient, after cheekbone lifting with dimple formation, the dimple on the left cheek had disappeared 3 days after the operation, due to pillow pressure. Immediate re-suturing was performed, which successfully reconstructed the symmetry and the smiling dimple.
Four patients had post-operative bruising at the lower lid.
The author has had no nerve injuries, no hematomas, no seromas, and no infections in the follow-up clinical cases.
In 2 patients, on the first post-operative day, an additional pull on the skin was performed to obtain lifting-level symmetry on both sides. The correction was performed under local anesthesia.
In the first 3-4 days, five patients complained about having a perception of an overcorrection or an exceedingly high lift and projection of the cheek-bones. This is normal during the maximum swelling period. These complaints disappeared in 5 to 10 days. One Asian patient did not feel comfortable with the new cheekbones and the sutures were removed 30 min after operation.
Serdev Sutures® can be placed, removed and replaced at any time with nearly no down time.
There were 12 cases of late secondary repetition after 5 to 12 years, as part of a total face maintainance, combined with suture lifts in neighboring facial areas.
Except lifting and augmentation, the cheekbone lift forms nice, young looking “hungry” cheeks. In elderly patients, the cheekbone lift gathers tissue, resolves the tear trough fold, projects and lifts the cheekbone (as part of beauty triangle), lifts, flattens nasolabial and marionette folds, and stretches the jaw line. In young patients it projects, enhances and elevates cheekbones. Cheekbone volumizing is part of the beauty triangle formation (projected cheekbones and chin). Additional chin enhancement using sutures is always advisable if the chin is not projected enough. Patient satisfaction is closely related to the individual possibility of obtaining correct proportions, volumes and angles of the face, including cheekbones.
To date, there are not many methods for cheekbone lifting and volumizing without implants and transplants. Classic rhytidectomies do not correct volume and do not change proportions even with modern endoscopic methods. Simultaneous suture SMAS lifts, even in open surgery during rhytidectomy, can improve the cheekbones, lower face and jowls. This method, especially the suture tissue volumizing without the use of implants or transplants is unique. Classic rhytidectomies cannot lift cheekbones in a medial direction and most of the time use implants. This also demonstrates the pre-eminence of the author’s method. Complications in scarless closed approach suture techniques are rare (less than 0,1%). In other invasive surgeries, the rate increases with the extension of the surgery.
Cheekbone lift using the scarless, transcutaneous, closed approach Serdev Suture® method is ambulatory, very well tolerated by patients, with immediate effect. The recovery period is very short and patients can return to their social life and work almost immediately. Complications are less than 0,1% and patient satisfaction is extremely high, especially with regards to aesthetics. A particularly positive advantage in suture lifts is the possibility to select the position, volume and level of cheekbone enhancement and lifting. Patients prefer the possibility of total facial improvement, in combination with neighboring facial areas, as part of the mini-invasive procedure.
In the face, Serdev Suture® techniques lift the mobile SMAS and fix it to stable immobile anatomical structures. Scarless Serdev Suture® mid-face lift sutures loose zygomatic SMAS extension to firm temporoparietal tendon insertion and underlying temporal periosteum. Such a lift results in lifting the mid and lower SMAS, restoring cheekbone into a higher position, resolving the tear trough, nasolabial and marionette folds, stretching mid-face SMAS and attached skin in a temporoparietal direction. Lower face and neck are also improved. Serdev Suture® lifting techniques are ambulatory, performed under local anesthesia, very well tolerated by patients, with an immediate effect, with an extremely short post operative period, fast recovery and nearly immediate return to social life. Complications are about 0% and patient satisfaction is very high, especially in the aspect of aesthetics.
The author has created special, curved, semi-blunt and semi-elastic needles of different lengths, with an eye at the tip (Fig. 23). For mid-face lift, needles with lengths of 50 mm, 60 mm, and 100 mm are used to introduce long-term absorbable (in 2-3 years), semi-elastic Polycon surgical sutures USP 2 and 4.
Curved, semi-blunt and semi-elastic needles with different lengths of 50 mm, 60 mm, and 100 mm and an eye at the tip.
Local anaesthesia with i.v. sedation is used instead of general anaesthesia, in order to shorten intervention time, along with both surgeon and patient preference.
A-B – stable fixation to immobile temporoparietal tendon insertion and underlying periosteum.
A1-B1 – fixation of mobile zygomatic SMAS extension.
Scheme of mid-face lifting – fixation of zygomatic extension of SMAS (line A1-B1 below zygoma) to temporoparietal tendon and temporal periosteum (line A-B), just above the ear at temporoauricular angle. The vector is from chin to temporoparietal tendon - in temporoparietal direction. Thus, the mid-face SMAS and marionette lines will be stretched. Connection lines A-B1 and B-A1 are crossed to reduce bulging.
The fibro-muscular layer, described as Superficial Muscle Aponeurotic System (SMAS), connects the vertex and platysma and acts as suspension for the overlying facial skin. SMAS is fixed to the zygoma by the zygomatic SMAS extension that permits movement of the lower SMAS. In direction towards the zygoma, at the superior orbital rim level, the immobile temporalis fascia (or deep temporalis fascia in some textbooks) splits in two immobile layers: superficial and deep layer. These two immobile fascial layers enclose an intermediate fat pad and within - frontal branches of facial nerve, artery and vein. The frontal branch of the facial nerve is considered to cross the zygomatic bone, traveling along a line, connecting the tragus base to a point 1.5 cm above the eyebrow.
So, the anatomic topography forms a square - 3 cm front of the tragus and 3 cm above the zygomatic bone that is described by the author as a
Temporoparietalis muscle tendon is fixed to spina suprameatica of meatus acusticus externus. It is stable, immobile and is used by the author for firm cephalic fixation of the suture in mid-face lift.
SMAS zygomatic extension is a mobile fascia which is used by the author to lift mid and lower SMAS.
The mobile A1-B1 SMAS fixation to zygoma will be lifted to the immobile A-B line at the temporoparietal tendon insertion and underlying temporal periosteum.
Temporoparietal direction from chin to temporoauricular angle - point A, with strong effect of traction on cheek SMAS, on the marionette folds and additional effect on the nasolabial folds,
Dorsal direction from cheekbone to point A, with strong effect on the nasolabial and tear trough folds and additional effect on marionette folds.
Video: http://www.youtube.com/watch?v=S51JZOCfLfg
Mark perforation points A, B and B1 for skin perforations. Entry point A is placed just above the ear, in the temporoparietal angle, and point B - approximately anteriorly to A, at the hairline. Point A1 is only a mark and should be not perforated. Point A1, line A1-B1 and point B1 should be below the lower line of zygomatic arch, i.e. lower than the mobile SMAS zygomatic extension. Perforation point B1 is placed at intersection point of chin to temporoauricular angle line and lower zygomatic line.
Line A-B is the subperiosteal immobile fixation to temporoparietal tendon insertion and underlying temporal periosteum. A1-B1 is the line of fixation below mobile SMAS zygomatic extension.
Local anesthetic is introduced intradermally at points A and B, then subperiosteally at the line A-B, just subdermally in connection lines B-A1 and A-B1, and deeper subdermally in line A1-B1. Use only a small amount of anesthetic – a few drops per line. Larger amounts will result in visible post-op swelling.
The skin is perforated with a No. 11 scalpel blade in points A, B, and B1 (respect Langer lines) and then, using the thin tip of a mosquito clamp, the skin perforations at point B1 will be widened and deepened.
Introduce a “mini” 60 mm Serdev® needle in a perpendicular fashion through point B (do not engage dermal tissue), then slide it strictly subgaleally/supratemporally in direction to point A1, then rotate it toward B1. When the needle tip reaches a position below point B1, direct the tip upward toward opening B1, then fold the skin against the needle tip at a 900 angle and with a gentle twisting movement direct needle upward, until it exits from point B1. Try to avoid engaging dermis as you are exiting, in order to prevent creation of skin dimples.
After the needle is threaded at point B1, it is pulled back until it exits through point B, bringing the suture with it. This represents the pass, which fixes the movable SMAS zygomatic extension.
The second needle pass is subdermal, between points
After exiting perpendicularly through point
Introduce a specially bended “mini mini” 50 mm Serdev® needle in a perpendicular fashion through point A (do not touch or engage dermal tissue!). Once the needle touches the bone, slide it subperiosteally to point B.
When the needle tip reaches a position below point B, direct the tip upward towards opening B, then fold the skin against the needle tip at a 900 angle and with gentle twisting movements direct needle upward until it exits from point B. Avoid engaging dermis as you are exiting, in order to prevent creation of skin dimpling. If you feel that the needle is facing any resistance, it means that the needle has caught the dermis, in which case move the needle backwards and repeat the maneuver.
After threading the needle at point B, it is pulled back towards point A until it exits, bringing the suture with it. This will complete the suture circle formation and a surgical knot is performed, using optimum tension. Use one branch of a mosquito clamp to release dimpling at the perforation points.
The author does not use stitches to close perforation points A, B or B1. They are taped for overnight. On the next day, patients should take a shower with shampoo to remove blood residuum at the perforation points. Multiple disinfections are applied by the patient on a daily basis, for 3-4 days. Some swelling (like soft bulging) in the area can be visible for 3-4 weeks and then disappears. Patients usually cover it with their hair.
520 patients were followed up from 3 to 18 years, starting in 1993. In 95% of the cases, patients had simultaneous treatment in other face and/or body areas. In the face, combinations were mostly with temporal, brow lift, lower SMAS-platysma lift, chin enhancement and beautification rhinoplasties.
Results were excellent in 96% of all cases, as reported by our patients. Patients’ satisfaction is mostly connected to the immediate aesthetic result and visible rejuvenation of the medial and lower face, local anesthesia, short operation time, lack of pain, immediate or rapid recovery and speedy return to social activities or work. There is an almost complete correlation between aesthetic outcomes with pre-operative patient expectations.
In the first 7-10 days patients experience a traction sensation. Most patients find this sensation desirable and are attracted to it. Some pain was reported when pressure is applied to the area, which is considered normal.
After three years, results are reported to remain satisfactory in 85% and good in 12% of the cases.
In five years, 52% of the patients report satisfaction and 37% consider results as good.
Only in 3 cases the mid-face lift has been repeated after 4, 6 and 8 years. Such additional suture lifts and enhancements have mostly been performed to complete or maintain a good status.
Before and after mid-face lift and simultaneous brow lift using Serdev Sutures®. Better cheekbone position, and jaw line, formation of so-called “hungry cheeks”. Face is tightened and changed from “square” to oval.
Before and after mid-face lift and simultaneous brow lift using Serdev Sutures®. Better cheekbone position, and jaw line. Face is changed from “square” to oval.
Before and immediately after mid-face lift and simultaneous brow lift using Serdev Sutures®. Better cheekbone position and jaw line. Face is tightened, refreshed and changed from “square” to oval.
Before and after mid-face lift using Serdev Sutures® and simultaneous ultrasonic assisted liposculpture of buccal fat. Better cheekbone position and jawline. Face is tightened, totally refreshed and changed from “square” to oval.
Before, immediately after and 4 years after mid-face lift and simultaneous temporal, brow, lower face and neck lift using Serdev Sutures®, and rhinoplasty.
Before and immediately after mid-face lift to equalize both sides in a case of facial paralysis.
There was no case of secondary correction after mid-face lift except the three reported in a late stage. In one case, during hands-on training, a growing swelling was marked in a unilateral “danger area”. Having in mind a possible trauma, pressure was applied for 10 minutes. This swelling successfully flattened and the operation was finalized. No bleeding, hematoma or bruising in the area was observed in the early post-operative period.
The author has had no infection, hematoma, seroma, or nerve injury after suture mid-face lifts.
Skin lifting in classic subdermal and deep rhytidectomies does not significantly improve nasolabial and marionette folds. Flattening of marionette and nasolabial folds with the suture technique demonstrates its superiority over invasive lifting methods, where complication rates rise with extensive surgery.
Mid-face lift using Serdev Suture® methods is ambulatory, very well tolerated by patients, with immediate effect, with an extremely short post operative period, fast recovery and nearly immediate return to social life. Complications are near 0% and patient satisfaction is very high, confirming the longevity of results.
The advantages of the suture lifts include the possibility to correct and improve anatomy at any time, with nearly no down time, no trauma, and high patient satisfaction.
The author describes his experience and methods in different aesthetic disproportions of the external nose and in secondary cases.
Rhinoplasty is a part of the beautification process and has to follow anatomical proportions and beauty principles. Nose length has to occupy the middle 1/3 of the face, according to the proportions of the “golden section” rule of 3 equal thirds.
Proper nose
Proportional nose is one that occupies 1/3 of the face (golden dividing rule). Proper volumes are: thin dorsum, thin tip, narrow allar base. The tip of the nose prominence gives volume to the central face and its position should be in harmony with the beauty triangle (projected cheekbones and chin). The tip should be in the line of the cheekbone prominences. The nasal dorsum should be straight or slightly concave. Best angles are: 900 angle at the tip, 1100 nasolabial angle, 300 angle of nostrils to columella, 300 dorsum to profile line.
The aim of Serdev Suture® techniques in beautification rhinoplasty is to improve the above mentioned aesthetic proportions, volumes and angles not only of the nose but adapted to the face as a whole. Serdev Sutures® include tip refinement, tip rotation, and allar base narrowing.
Earlier nasal tip techniques were based on cartilage removal that can destabilize the nasal framework and nasal tip support. Later, radical cartilage resections have been replaced by reshaping and reorienting of the nasal tip components. Suture techniques of the nasal tip in open surgery became popular with McCollough and English double-dome unit procedure to increase tip projection and refinement, using a horizontal mattress suture through all 4 crura just beneath the domes; with Goldman tip procedure for the wide or bulbous lobule, with Daniel domal creation suture, a horizontally placed mattress suture, which shaped separately each dome. Numerous suturing techniques appear in the open technique rhinoplasty literature. All suture techniques are used in open surgery.
Serdev Sutures® tip refinement techniques represent scarless
The suture is made through the domal part of the lower alar cartilages. The traction during knotting the suture is visibly tractioning the tip by the side. Be careful not to enter through the nostril as this will cause suture contamination.
The suture consists of 2 needle passes, using 2 skin perforations, without engaging skin. Each needle pass uses a different but parallel path through the cartilages. The transdermal suture is diving, buried below the skin, attaching only cartilages, without including skin in the suture. Skin perforations can be moved per side with each pass, in order to obtain parallel passes with a 2-3mm distance between. Both needle passes have to be placed in the domal area, without perforating the nostril, in order to prevent contamination and compromising the result.
This method is usually combined with other author’s closed rhinoplasty techniques, such as T-excision and columella sliding. The suture should be placed as high as possible to fix the domal medial crura. There is no need for this suture to be buried below the nasal mucosa, as the latter is involved on each side. Using absorbable sutures, the fibrosis stabilizes the effect after the first 3 - 4 weeks. If suture is not absorbable, it has to be removed after 3 weeks.
Both transdermal and transmucosal sutures give good refining definition and at the same time a projection effect. In cases of bulbous tip, transdermal suture of all 4 crura is preferable. Both sutures can be used separately, combined, or as a part of a rhinoplasty.
Video: http://www.youtube.com/watch?v=nRh8NDSgDck
Nasal tip rotation in a Caucasian patient with properly sized septum and excess of skin at the tip.
Nasal tip rotation for proportional beautification in a young patient. Nasal tip at the line of the cheekbones results in beautification
Two lines of the suture are important: the nasal bone subperiosteal pass that represents the immobile fixation and the subdermal pass in columella, fixing the mobile medial crura of the greater alar cartilages. Using 2 subdermal connecting passes, the circle of the suture is fulfilled and knotted. In each skin perforation point, the suture dives without engaging skin.
Nasal tip rotation by suture is mostly useful in Asians and Afro-Americans, having softer septum and unstable columella. In Caucasians, such suture lift is possible if the soft tissue is hanging over a normal length septum. In cases with a hard and elongated septum the tip cannot be lifted by suture and another author’s technique is performed – the T-excision and columella sliding, which could be supported by that suture. This suture is very helpful to align the dorsum, especially in irregular dorsum and secondary rhinoplasties.
Nasal tip rotation for projection in an Asian patient with unstable septum columella.
The suture represents 2 parallel passes (1-2 mm distance between them), using 2 skin punctures at both nasolabial angles. The cartilages are engaged to stabilize the suture on both sides. The suture lines should pass subdermally, exactly below the nostrils and nasal spine.
Before and after alar base narrowing in an Afro-American patient.
Tip rotation using T-excision and Columella sliding in a young Caucasian female to form the golden section rule (3 equal parts of the face) and obtain beautification. Tip refinement by suture is performed to reduce the volume of the tip.
Tip Rotation and refinement by suture.
Nasal tip rotation, tip refinement and cheekbone lift. The nasal tip should be at the line of the cheekbones, otherwise it destroys the beauty triangle.
Nasal tip rotation for proportional beautification in a young patient. The hanging soft tissue and a shorter septum permits the tip lifting by suture.
Nasal tip rotation for proportional beautification in a young patient. Location of the nasal tip at the line of the cheekbones.
Before and after tip refinement and alar base narrowing in a Caucasian patient. Additional brow lift designs the brow.
Serdev Suture® techniques in rhinoplasty are time-saving, preventing trauma, with immediate results. The post-operative period is short, with no downtime, no or minimal bruising, immediate or prompt return to work and social life. No bandages are necessary.
Alar base narrowing is very important beautification in Afro-Americans and Asians. It provides refinement in Caucasian faces.
Various techniques have been proposed to correct prominent ears. The author presents a simplified method of auriculoplasty with sutures, by needle perforations only, without incisions. The key point of the operation is a line of sutures along the planed antihelix fold to transfix the fold at the antihelix tail, bending the scapha over the conchal cartilage to make the earlobe fall into place. The results are satisfactory, with a naturally looking antihelical fold.
This surgery is usually done to set prominent ears back, closer to the head, or to reduce the size of the visibly large ears. Prominent ears usually concern children from 4 to 14 years of age, but also adults. Non-suture techniques usually take about two to three hours, although complicated procedures may take longer. Most of the methods use incisions in the back of the ear. The cartilage is then sculpted. Occasionally, a piece of cartilage could be removed to provide a more natural-looking fold. Non-removable stitches are mostly used to help maintain the desired shape and position of the ear. Other techniques involve a similar incision in the back of the ear. Skin is removed and stitches are used to fold the cartilage back on itself to reshape the ear without removing cartilage.
Author’s sutures without incisions offers a simplified method to suture cartilage on both sides from the desired fold, without the need to incise or excise skin or cartilage.
The most common deformity of the ear is the uni- or bilateral prominent ear. This deformity is caused by the lack of formation of the natural fold along the antihelix, a hypertrophied concha or a combination of both. The auriculo-mastoid angle is normally 20–30° from the skull. The helical rim lies about 17–20 mm from the skull. The scapho-conchal angle is 90°, and if this angle is flattened, the ear appears protruding. The size and depth of the concha affect the deformity and the surgical technique for correction.
To pin the ears closer to the head, bring the ear elements into harmony, refine ear shape and reduce large elements.
Inferiority Complex, Personal Aesthetic Requirements and Needs.
Surgeon and parents should never insist on surgery until the child wants the change. Pre-operative evaluation includes clinical and photographical examination. Pre-operative photographs assist in the study and evaluation of the deformities and in making appropriate decisions. Photographs demonstrate the problem from many angles. Surgery on both ears could be suggested for balance, even if only one ear appears prominent.
In all cases, the author uses local anesthesia in combination with i.v. sedation
Twenty-five patients with prominent ears (without necessity of excision of a strip of the deep concha) were included in this study: 13 patients with unilateral protruding ears and 12 cases with bilateral prominent ears. Ages ranged between 5 and 35 years (15 females and 10 males).
Ear surgery was performed as an outpatient procedure. All the cases were operated under local anesthesia with adrenaline 1/1 000 000 injection of the posterior surface of the auricle. If anterior approach is necessary, local anesthesia is used subcutaneously in the specific area.
The suture method aims to suture the cartilage on both sides of the desired antihelix fold, using skin punctures only.
The sutures were performed starting from the upper part of the tail to the lower end of the antitragus in order to disrupt the strongest point where the helix, antihelix and antitragus join.
Two 0,7-0,8 cm long parallel lines are marked on both sides of the planed antihelix fold - for example: A-B and A1-B1. If necessary, a row of additional sutures is planned, such as B-C and B1-C1, C-D and C1-D1 etc. In most Asians, Afro-Americans, Latino-Americans who have soft cartilages, as well as in some Caucasian kids, less sutures could be enough, but in stronger cartilages 3 and more sutures are usually necessary to bend the cartilage and form the desired fold. The lines A-B and A1-B1, B-C and B1-C1, C-D and C1-D1 etc. mark the parallel subperihondreal transcartilagenous passes. The connecting lines between A-A1, B-B1, C-C1 and D-D1 are only subcutaneous to connect the transcartilagenous passes and bring them together. The length of the parallel transcartilagenous and connecting subdermal lines are pre-planned in respect of ear size and the desired result. Subcutaneous dissection in the area of the sutures can be done through the skin perforations, using Serdev® needles. To perform the technique, the author uses a Serdev® “mini-mini” needle, a USP 3/0 surgical suture and 4 skin perforations per suture in the posterior or anterior ear surface. The order of the passes depends on the surgeon (left or right handed), ear side, and surgeon skills. The author starts with a transcartilagenous needle pass - for example A-B, takes the suture end and positions the suture through the needle pass. After that he makes the 2 subcutaneous connecting passes to introduce both suture ends subcutaneously. Then, the second transcartilagenous pass A1-B1 is made at the other side to finalize the suture. When all sutures are done, the tightening of the knot should be done under elastic medium tension to adapt, but not to squeeze, cut or traumatize the cartilages.
When all necessary sutures are done and tightened on both ears, symmetry is checked. Symmetry is usually obtained by the method itself. In 3 cases symmetry was perfected with additional suture on one side and in 2 cases with additional sutures on both sides. The prominent ears were corrected without incision or excision of skin from its posterior surface and without excision of cartilage. The antihelix was weakened by the line of sutures on its posterior surface and the antihelix fold was obtained successfully by the sutures only.
Before,
Before,
All patients had no need or have refused excision of the concha. In 5 cases, where lowering of the concha was necessary, the author has performed sutures of the concha cartilages to the occipital periosteum or mastoid with a good result.
Anterior surface sutures were used in 6 easier cases, when patients asked for minimal corrections, in 2 cases of difficulties with the equality and in 2 cases of secondary corrections.
A suture is done on the right ear, on the anterior surface.
Adults and children are usually up and around within half an hour after surgery.
Any activity in which the ear might be bent should be avoided for a month or so. Most adults can go back to work on the day after surgery. Children can return to school activities 2 to 3 days after the operation, if they are motivated and careful about playground activity.
The procedture was accepted very well both by children and adults and the results were described as very satisfying.
Complications are infrequent and usually minor. Nevertheless, as with any operation, there are risks associated with surgery and specific complications associated with this procedure. Incomplete correction of prominent ears is probably the most common and undesirable outcome in otoplasty. Hematomas or seromas can complicate recovery and should be managed as soon as possible. Hypertrophic scars or keloids may form along the incision line.
In his patients, the author has not observed hypertrophic scars or keloids. There were no seromas, no infection or blood collection.
Additional unilateral sutures (to complete aesthetic desire) were added in 3 patients, 4-6 months after the primary surgery. There have been no overcorrection or chondritis. Additional sutures can be done at any time, with no downtime or loss of social contact and work time.
The goal of the suture technique in auriculoplasty is improvement and beautification, but not perfection. Perfect symmetry is unlikely and unnatural in human body, including the ears. Both ears never match perfectly (Fig. 52, 53). Patient and parent expectations should be discussed before the operation.
If the child is young, some surgeons may recommend general anesthesia, (the author uses local). For older children or adults, surgeons may prefer to use local anesthesia. Children who want the surgery and are motivated, cooperate better during the operation. The author has used local anesthesia, combined with intravenous sedation in all cases, and children do not remember the operation time.
The operation is mostly performed on children between the ages of four and fourteen. Ears are almost fully grown by age four. Ear surgery on adults is also possible and there are generally no additional risks. Discussion on state of the art techniques is always necessary like descriptions of the techniques such as Zplasty and Sandwich methods. In cases of inferiorly bulging concha an open surgery is suggested to correct the lobule and to maintain it posteriorly. In different techniques the auricle can be attached to the skull around the external meatus. Other authors use removal of cartilage where it is attached to the mastoid, with the aim of preventing the spring action of the auricle on the skull bone. The size of the concha will be taken into consideration for its correction and the proper evaluated size of cartilage to be excised.
Proper pre-operative evaluation is an essential step for satisfactory results. Not deviating from the decisions taken before the operation will avoid unnecessary excision that cannot be corrected later.
Good otoplasty makes the ears more proportional to the size and shape of the head and face.
The main function of the ear is hearing. Cosmetic ear surgery can reshape deformed or protruding ears and restore proportions.
Water is the resource that sustains all life on the planet earth and key element of sustainable development [1]. The rapid growth in population, and industrial and economic development needs high demand of water. The need of freshwater for drinking and potable water in arid areas is increasingly important issues in most part of the world. In 2000, the world annual demand for water is 4000 billion cubic meter. By 2030, it is estimated to increase over 58% [2]. Water availability per person in Pakistan was 5,600 cubic meter in 1960, and it is reduced to 1000 cubic meter in 2018. The demand of water in Pakistan is important because of its agrarian nature of economy and the agriculture sector shares 24% of gross domestic product (GDP). The regional conflicts on the availability and use of water have pressure on the demand of water. The water sources in Pakistan are surface water, rainfall, glaciers, and groundwater. Surface water consists of rivers, lakes, dams, and runoff during and after heavy rains. Mostly, the groundwater is the source in urban areas except in Karachi, Hyderabad, and some part of Islamabad use surface water. Water for rural areas is also from groundwater source except in saline groundwater areas where irrigation canals are used for domestic purpose [3]. Currently, the water availability per capita in Pakistan is 1000 cubic meter. According to Population Action International, 1993, the countries with water availability below 1000 cubic meter experience chronic water stress [1]. Presently, more than 65% people of total population have access to safe drinking water including 85 and 55% urban and rural areas, respectively. The 35% of population has lack of drinkable water in Pakistan [3]. According to WHO, a drinkable water should have dissolved salt concentration less than 500 ppm. The normal seawater and brackish water have dissolved salt and ion concentration of 3500 ppm and 1000 ppm. Therefore, desalination of seawater and brackish water is the way to make the water drinkable. Most of the desalination plants use conventional methods of energy. But the fossil fuel methods of energy sources have adverse impact on environmental sustainability by producing air pollution, global warming, and GHGs emission. The utilization of fossil fuels for the desalination plants is contributing in CO2 emissions. The total installed power plant for the desalination processes is responsible for the emission of 76 million tons (Mt) of carbon dioxide per year. In 2040, the emission of CO2 is expected to 218 million tons per year [4]. The cuse of fossil fuels for desalination plant is neither sustainable nor environment friendly. Therefore, there is a need of alternative sources of energy to achieve the world demand of freshwater. At a same time, the alternative source should be sustainable and environmental friendly. The renewable energy sources of energy are the alternatives to power desalination processes. Thus, the solar power desalination is one of the most suitable alternatives for desalination plant that meets water demand and also environmental friendly.
Therefore, in this research paper the focus is on the demand of water in Pakistan as the result of rapid growth in population and industrialization. It has become necessary to install the desalination plant in Pakistan by keeping in mind the energy available as well as economic situation. The main ambitions of this research are to select a site having plenty of solar radiations and salt or brackish and suitable solar technology having low capital and operational cost to fulfill the demand of pure water at minimum cost. Thus, the development of mathematical model of solar stills and cost analysis at Lyari River, in Karachi, follows the solution of mathematical model using MATLAB.
The methodology of this research is composed of the selection of site in Pakistan for solar power desalination following the mathematical modeling of the single slope of solar stills and employs modern software for the solution of mathematical model. The governing equations for mathematical model of the solar stills are based on the law of conservation of mass and law of conservation of energy for the system. The equations for convective heat transfer coefficients and radiation heat transfer coefficients are based on the Dunkle’s model. The MATLAB r2019 is employed to solve the equations.
The availability of
The basic assumptions while modeling the solar stills take negligible temperature stratification within the evaporator basin. Temperature is uniform within each still component. Temperature is time dependent. The evaporated water is assumed only pure water; that is, the evaporated water has no dissolved salt or ion. The stills have no vapor leakages. The governing equations are based on law of conservation of mass and law of conservation of energy. The schematic of single slope solar stills is shown in Figure 1.
Schematic of single-slope solar stills.
The law of conservation of mass can be written as [7].
If
The solubility of salt determines the salt content in the brine. The salt content in the brine is important in practice to avoid the problem of forming layer and blockage. The factor
This factor is used to fix a threshold limit to not exceed during evaporation and condensation. By solving Eq. (2)) and Eq. (3), we have the following equation.
Eq. (5) is for the stationary conditions, the rate of evaporated water as a function of rate of feed saline water. Now, the distillated water or recovery rate can be defined as
The recovery rate is an important parameter, which indicates the possible amount of distillate water from the saline feed water without scaling [7]. It means that only 40% of saline water can be transformed into distillate water without encrustation and blockage.
The law of conservation of energy gives the following set of equations for the respective components in the solar stills.
The energy balance equation for the outer of the transparent glass cover is as follows [7]:
The energy balance equation for the inner of the transparent glass cover is as follows:
The energy balance for the seawater inside the basin of solar still is as follows [7]:
The convective heat transfer coefficient of between the outer of the transparent glass cover and the ambient temperature depends on the wind velocity. According to McAdams correlation [8], this coefficient is approximated by the following equation.
The heat transfer coefficient between the saline water and the inner of the transparent glass cover is given by the second form of Dunkle’s model and can be written as [9].
The radiation heat transfer coefficient between the outer of the transparent glass cover and the sky is given by
The sky temperature is determined by [10].
Where Ɵ is the dew point temperature given by [11].
The radiation heat transfer coefficient between the saline water and the sky is expressed as
Emissivity is given by,
The equation in the second part of the (Eq. (9)) in given by Dunkle’s model as [9].
The latent heat of vaporization
The evaporative heat transfer coefficient hev is given by [9].
The evaporative heat transfer coefficients Eq. (11) and Eq. (19) can only be estimated through correlations when the following conditions is satisfied: the aspect ratio
If the above conditions are not fulfilled, then it could be done either experimentally or by using 2D modeling of the problem such as considered in some other systems [12, 13].
The Nusselt number is obtained through a correlation in the form by to express the convective heat transfer coefficients [14].
The Grashof and Prandtl number is given by,
The correlation that gives Nusselt number is [14].
When the Nusselt number is known, the heat transfer coefficient between the basin liner plate and the saline water can be calculated for an active solar still as
The convective heat transfer coefficient between the fluid and the plate for an active solar still is calculated as [15].
The heat loss coefficient is approximated by the following equation [15].
Tb,out can be assumed to be equal to that of the plate Tp for larger length of basin liner for an active solar stills [15].
The MATLAB’s solver for ordinary differential equations (ODEs), MATLAB ode45 function, has been employed for the efficient computation of the differential equations.
The material properties and dimensions of solar still are given in Table 1 and thermophysical properties of glass, basin, and insulation are given in Table 2 in Appendix A.
Parameter | Value |
---|---|
Basin Area | 0.2 |
Thickness | 2 |
Basin Material | Aluminum |
Insulation | Wool |
Thickness | 20 |
Channels | PVC |
Glass | Tempered |
Glass Area | 0.234 |
Thickness glass cover | 0.04 |
FRL Lens | R18 |
Lens Area | 0.2839 |
Material properties of solar stills.
Parameters | Value |
---|---|
Basin absorptivity | 0.90 |
Glass absorptivity | 0.05 |
Water reflectivity | 0.05 |
Glass reflectivity | 0.05 |
Glass emissivity | 0.94 |
Water emissivity | 0.95 |
Specific heat | 4.002 |
Glass thermal conductivity | 1.03 |
Insulation thermal conductivity | 0.0363 |
Water depth | 0.02 |
Wind velocity | 4.6 |
Thermophysical properties.
Cost(PKR) | Without FRL | With FRL |
---|---|---|
Capital | 3550 | 19500 |
Operational | 1200/year | 1200/year |
Maintenance | 500/year | 500/year |
Cost of solar stills with and without FRL lens.
The hourly production of distill water in
Result of mathematical model of single slope solar still.
The maximum ambient temperature and sky temperature on the hottest day is 39.5°C and 14.7°C. The result is showing that the maximum water temperature with and without Fresnel (FRL) lens is 82.3°C and 47.2°C. And also the maximum glass temperature with and without FRL lens is found to be 80°C and 39.5°C. The production of water is calculated using the temperatures. The maximum water production with and without FRL lens is 8 kg/hour and 1 kg/hour. Using FRL lens, the production of water is 330% more than without using FRL lens.
The cost analysis of the solar still with and without FRL lens includes the capital, operational, and maintenance cost. The major contributor is FRL lens that cost 90$. The details of the costs are given in Appendix A.
The economic performance is estimated by the following.
The monthly operating cost is about 1.25$. There is no maintenance cost is required in this case but only the cleaning cost. The accidental cost is not considered in this study. The cost with FRL is 122.3$ and without FRL is 22.27$. The production of distilled water per cubic meter with and without FRL is found to be 1.37$ and 1.66$, respectively.
It is concluded that the scarcity of pure water can be compensated by desalination processes to meet the global demand of water as some developing countries have already done. The developed and developing countries have the capacity to install the conventional source of desalination plant but this attitude is greatly impacting on the environmental issues such as global emissions of CO2 and greenhouse gases (GHGs). Currently, the desalination plants are based on the conventional sources of thermal energy. The sustainable development goals (SDGs) can only be achieved using the renewable source of energy for the desalination processes. This will eliminate two main problems: global emissions and scarcity of water. The alternative and most effective source for desalination processes keeping in mind the SDGs is the solar thermal desalination processes. The capital and operational cost of the conventional thermal desalination processes are high enough that under developing countries cannot afford it. Therefore, the solar thermal desalination processes are the best option for those countries. The plenty of solar irradiance, water, and land make Pakistan the best suited area for the solar thermal desalination. Baluchistan, Sindh, and Southern Punjab are the most suitable area for the solar energy applications. The Lyari River at Karachi in Sindh province is one of the most suitable areas for the solar thermal desalination processes. The solar stills technology for the distillation of saline water is one of the most favorable technologies to distill water to meet the water demand of Pakistan at effective cost. The governing equations of mathematical modeling of solar still were based on law of conservation of mass and law of conservation of energy. MATLAB was employed to solve the governing equations of the mathematical model. The result is showing that the utilization of Fresnel (FRL) lens makes the solar stills more productive of distill water as compared with solar stills without Fresnel lens. At the same time, the cost of pure water is less while using FRL lens in the solar stills. The solar stills technology works more efficiently at the remote areas of Pakistan where high-cost desalination plants are far enough to install. And ease of installation, capital, operational, and maintenance cost make it possible to reach to all people.
I pay gratitude to Allah Almighty for His blessings that make possible to complete this research paper. Our heartedly gratitude to our parents and guidance that they support us from childhood to present. Besides their support, it was impossible for us to do so.
It is my pleasure to acknowledge here the personal and institutional support I have received leading to the completion of this work. I am thankful to my team members, Muhammad Irfan and Anwar Khan, student of B.Sc. Mechanical Engineering Department at University of Engineering and Technology, Lahore, for their cooperation.
On the behalf of my team I would like to express sincere gratitude to Professor Nasir Hayat, Chairman Mechanical Engineering Department, University of Engineering and Technology Lahore for his continuous supervision, advice, effort, and worthy suggestions during the entire research project. At Mechanical Engineering Department, University of Engineering and Technology, Lahore, I am grateful to project coordinator Dr. Naseer Ahmad, Associate Professor Mechanical Engineering Department, and his fellows for their valuable and estimable suggestions. And special thanks go to our semester coordinator Dr. Zia ur Rahman Tahir.
I would like to thanks all the researchers and coordinators of the websites that their research articles are easily available at the respective websites. It is my pleasure that to express thank to Maja Bozecevic, Author Service Manager at IntechOpen, which is world-leading publisher of Open Book Access.
There is no conflict of interest for this publication.
Asw | Area of saline water (m2) |
Ag | Area of glass cover (m2) |
Ab | Area basin (m2) |
A | Aspect ratio (dimensionless) |
c | Constant in Nusselt correlation (dimensionless) |
cp,b | Specific heat of brine (J kg−1 K−1) |
cp,sw | Specific heat of saline water (J kg−1 K−1) |
cp,g | Specific heat of glass (J kg−1 K−1) |
eg | Thickness of glass cover (mm) |
egs | Thickness of insulation material |
Fc | Feed concentration factor (dimensionless) |
I(t) | Solar Intensity (Wm−2) |
IO | Constant solar intensity (Wm−2) |
I | Inclination angle of glass cover (degree) |
Gr | Grash of number |
G | Acceleration of gravity (m s−2) |
Hl | Height of the higher side of the still (m) |
Hr | Height of the lower side of the still (m) |
H | Mean height of the still (m) |
hL | Latent heat of vaporization (kJ kg−1) |
hev | Evaporative heat transfer coefficients (kJ kg^−1) |
hcge-amb | Convective heat transfer coefficient between outer glass cover and ambient (Wm−2 K−1) |
hcsw-gi | Convective heat transfer coefficient between saline water and inner glass (Wm−2 K−1) |
hge-sky | Heat transfer coefficient between outer glass cover and sky (Wm−2 K−1) |
ṁsw | Mass flow rate of Saline water (kg m−3) |
ṁb | Mass flow rate of brine (kg m−3) |
mw | Mass yield hourly (kg m−3) |
ṁev | Mass rate of produced vapor (kg m−3) |
Nu | Nusselt number (dimensionless) |
N | Exponent in Nusselt correlation (dimensionless) |
Pr | Prandtl number (dimensionless) |
pgi | Partial pressure of the water at the interior of the glass cover (Pa) |
psw | Partial pressure at saline water surface temperature (Pa) |
Ra | Rayleigh number (dimensionless) |
Tamb | Ambient temperature (K) |
Tb,out | Brine output temperature (K) |
Tge | Temperature at the outer side of cover glass (K) |
Tgi | Temperature at the inner side of cover glass (K) |
Tsw | Temperature of saline water (K) |
Tsw,in | Inlet temperature of saline water (K) |
Tsky | Sky temperature (K) |
t | Time (s) |
tc | Time period for calculation of the yield (s) |
Uloss | Loss factor per unit surface (W m−2 K) |
Vg | Volume of glass cover (m3) |
Vsw | Volume of saline water (m3) |
v | Wind speed (m s−1) |
w | Width of the solar stills (m) |
xb | Concentration of salt in brine (mg l−1) |
xsw | Concentration of salt in feed saline water (mg l−1) |
αc, | Fraction of solar energy absorbed by basin liner material (dimensionless) |
αg, | Fraction of solar energy absorbed by glass cover material (dimensionless) |
αsw, | Fraction of solar energy absorbed by saline water (dimensionless) |
β | Coefficient of volumetric thermal expansion (K−1) |
βsw | Coefficient of volumetric thermal expansion for saline water (K−1) |
ϵeff | Effective emissivity (dimensionless) |
ϵg | Emissivity of cover glass (dimensionless) |
ϵsw | Emissivity of saline water (dimensionless) |
φ | Feed recovery rate (dimensionless) |
Γ | Yield (kg) |
λ | Thermal conductivity (W m−1 K−1) |
λg | Thermal conductivity of glass cover (W m−1 K−1) |
λsw | Thermal conductivity of saline water (W m−1 K−1) |
λin | Thermal conductivity of insulation material (W m−1 K−1) |
μ | Viscosity (N s m−2) |
μsw | Viscosity of saline water (N s m−2) |
ρ | Density |
ρg | Glass cover density (kg m−3) |
ρsw | Saline water density (kg m−3) |
σ | Stefan-Boltzmann^’ s constant (5.6697 × 10−8) (W m−2 K−4) |
θ | Dew point temperature (K) |
ε | Relative humidity (dimensionless) |
∆T | Temperature difference in transfer by natural convention (K) |
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Almost all the parts of this plant, that are, fruit, leaves, flower bud, trunk, and pseudo-stem, can be utilized. This chapter deals with the fiber extracted from the pseudo-stem of the banana plant. It discusses the production of banana pseudo-stem fiber, which includes plantation and harvesting; extraction of banana pseudo-stem fiber; retting; and degumming of the fiber. It also deals with the characteristics of the banana pseudo-stem fiber, such as morphological, physical and mechanical, durability, degradability, thermal, chemical, and antibacterial properties. Several potential applications of this fiber are also mentioned, such as the use of this fiber to fabricate rope, place mats, paper cardboard, string thread, tea bags, high-quality textile materials, absorbent, polymer/fiber composites, etc.",book:{id:"7544",slug:"banana-nutrition-function-and-processing-kinetics",title:"Banana Nutrition",fullTitle:"Banana Nutrition - Function and Processing Kinetics"},signatures:"Asmanto Subagyo and Achmad Chafidz",authors:[{id:"257742",title:"M.Sc.",name:"Achmad",middleName:null,surname:"Chafidz",slug:"achmad-chafidz",fullName:"Achmad Chafidz"},{id:"268400",title:"Mr.",name:"Asmanto",middleName:null,surname:"Subagyo",slug:"asmanto-subagyo",fullName:"Asmanto Subagyo"}]},{id:"69568",title:"Water Quality Parameters",slug:"water-quality-parameters",totalDownloads:9909,totalCrossrefCites:12,totalDimensionsCites:32,abstract:"Since the industrial revolution in the late eighteenth century, the world has discovered new sources of pollution nearly every day. So, air and water can potentially become polluted everywhere. Little is known about changes in pollution rates. The increase in water-related diseases provides a real assessment of the degree of pollution in the environment. This chapter summarizes water quality parameters from an ecological perspective not only for humans but also for other living things. According to its quality, water can be classified into four types. Those four water quality types are discussed through an extensive review of their important common attributes including physical, chemical, and biological parameters. These water quality parameters are reviewed in terms of definition, sources, impacts, effects, and measuring methods.",book:{id:"7718",slug:"water-quality-science-assessments-and-policy",title:"Water Quality",fullTitle:"Water Quality - Science, Assessments and Policy"},signatures:"Nayla Hassan Omer",authors:null},{id:"40180",title:"Plant Tissue Culture: Current Status and Opportunities",slug:"plant-tissue-culture-current-status-and-opportunities",totalDownloads:66452,totalCrossrefCites:43,totalDimensionsCites:89,abstract:null,book:{id:"3568",slug:"recent-advances-in-plant-in-vitro-culture",title:"Recent Advances in Plant in vitro Culture",fullTitle:"Recent Advances in Plant in vitro Culture"},signatures:"Altaf Hussain, Iqbal Ahmed Qarshi, Hummera Nazir and Ikram Ullah",authors:[{id:"147617",title:"Dr.",name:"Altaf",middleName:null,surname:"Hussain",slug:"altaf-hussain",fullName:"Altaf Hussain"}]},{id:"66996",title:"Ethiopian Common Medicinal Plants: Their Parts and Uses in Traditional Medicine - Ecology and Quality Control",slug:"ethiopian-common-medicinal-plants-their-parts-and-uses-in-traditional-medicine-ecology-and-quality-c",totalDownloads:4059,totalCrossrefCites:6,totalDimensionsCites:10,abstract:"The main purpose of this review is to document medicinal plants used for traditional treatments with their parts, use, ecology, and quality control. Accordingly, 80 medicinal plant species were reviewed; leaves and roots are the main parts of the plants used for preparation of traditional medicines. The local practitioners provided various traditional medications to their patients’ diseases such as stomachaches, asthma, dysentery, malaria, evil eyes, cancer, skin diseases, and headaches. The uses of medicinal plants for human and animal treatments are practiced from time immemorial. Stream/riverbanks, cultivated lands, disturbed sites, bushlands, forested areas and their margins, woodlands, grasslands, and home gardens are major habitats of medicinal plants. Generally, medicinal plants used for traditional medicine play a significant role in the healthcare of the majority of the people in Ethiopia. The major threats to medicinal plants are habitat destruction, urbanization, agricultural expansion, investment, road construction, and deforestation. Because of these, medicinal plants are being declined and lost with their habitats. Community- and research-based conservation mechanisms could be an appropriate approach for mitigating the problems pertinent to the loss of medicinal plants and their habitats and for documenting medicinal plants. Chromatography; electrophoretic, macroscopic, and microscopic techniques; and pharmaceutical practice are mainly used for quality control of herbal medicines.",book:{id:"8502",slug:"plant-science-structure-anatomy-and-physiology-in-plants-cultured-in-vivo-and-in-vitro",title:"Plant Science",fullTitle:"Plant Science - Structure, Anatomy and Physiology in Plants Cultured in Vivo and in Vitro"},signatures:"Admasu Moges and Yohannes Moges",authors:[{id:"249746",title:"Ph.D.",name:"Admasu",middleName:null,surname:"Moges",slug:"admasu-moges",fullName:"Admasu Moges"},{id:"297761",title:"MSc.",name:"Yohannes",middleName:null,surname:"Moges",slug:"yohannes-moges",fullName:"Yohannes Moges"}]},{id:"29764",title:"Underlying Causes of Paresthesia",slug:"underlying-causes-of-paresthesia",totalDownloads:192987,totalCrossrefCites:3,totalDimensionsCites:7,abstract:null,book:{id:"1069",slug:"paresthesia",title:"Paresthesia",fullTitle:"Paresthesia"},signatures:"Mahdi Sharif-Alhoseini, Vafa Rahimi-Movaghar and Alexander R. Vaccaro",authors:[{id:"91165",title:"Prof.",name:"Vafa",middleName:null,surname:"Rahimi-Movaghar",slug:"vafa-rahimi-movaghar",fullName:"Vafa Rahimi-Movaghar"}]}],onlineFirstChaptersFilter:{topicId:"2",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82508",title:"Introductory Chapter: Global Cotton Research Development Trends for the Past Five Years - Key Directions",slug:"introductory-chapter-global-cotton-research-development-trends-for-the-past-five-years-key-direction",totalDownloads:0,totalDimensionsCites:0,doi:"10.5772/intechopen.105748",abstract:null,book:{id:"11362",title:"Cotton",coverURL:"https://cdn.intechopen.com/books/images_new/11362.jpg"},signatures:"Ibrokhim Y. Abdurakhmonov"},{id:"82512",title:"Antimicrobial Residues in Meat and Meat Products",slug:"antimicrobial-residues-in-meat-and-meat-products",totalDownloads:1,totalDimensionsCites:null,doi:"10.5772/intechopen.105784",abstract:"The presence of antimicrobial residues (AMRs) in meat is considered a serious threat to public health in the twenty-first century. This work aims at addressing the problem of AMRs in meat regarding their sources, negative effects, detection tests, and prevention and control practices. The health risks associated with such residues include direct toxicity, drug allergy, hypersensitive reactions, and the development of antibiotic-resistant bacteria. Moreover, disturbance of gut microbiota and bone marrow disorders are also direct consequences of continuous exposure to small quantities of antimicrobial residues (AMRs). Due to long-term exposure to antibiotic residues during gestation, various congenital anomalies were also seen in newborn children. Carcinogenic impacts and mutagenic effects are other negative impacts of antibiotic residues on the food. Different practices are known to introduce AMRs into meat and meat products, such as misuse of chemotherapeutic medications, violating withdrawal periods, even with the proper administration of anti-infective agents, and usage of antibiotics as growth promoters and feed additives. The prevention of this problem requires multi-sector cooperation to restrict the improper use of antimicrobial drugs, standardize the rationale usage, and development of alternative chemicals or biologics for the purposes of preservation of meat products and as growth promoters for food-producing animals.",book:{id:"11638",title:"Meat Science and Nutrition - Recent Advances and Innovative Processing Technologies",coverURL:"https://cdn.intechopen.com/books/images_new/11638.jpg"},signatures:"Dhary Alewy Almashhadany, Hero I. Mohammed, Thaera Abdulwahid M. Muslat, Rzgar F. Rashid, Rawaz R. Hassan and Abdullah O. Hassan"},{id:"81539",title:"Biofilm Development in Gram-Positive and Gram-Negative Bacteria",slug:"biofilm-development-in-gram-positive-and-gram-negative-bacteria",totalDownloads:0,totalDimensionsCites:null,doi:"10.5772/intechopen.104407",abstract:"Biofilms are the communities of microorganisms, especially bacteria attached to a biotic or abiotic surface. These biofilms live in a self-sustained matrix and produce different substances called extracellular polymeric substances (EPS) which are responsible for the pathogenicity of a number of bacteria such as Pseudomonas aeruginosa, Staphylococcus aureus, Vibrio cholerae, Klebsiella pneumoniae, Escherichia coli, etc. These EPS substance makes it difficult to eradicate the biofilm present on the surface. Biofilm formation is a five-step process. Biofilms can be monospecies or multispecies. In biofilms, cells communicate via Quorum Sensing (QS). QS is the regulation of gene expression in bacteria with respect to changes in cell population density. In QS, bacteria produce various signaling molecules called Auto-inducers (AI). AI concentration increases as the bacterial population increases. Bacteria respond to these AIs results in an alteration of gene expression, which results in the release of various virulence factors. QS involves a two-component signaling process which is different for both Gram-positive and Gram-negative bacteria. QS and EPS make the bacteria resistant to various antibiotics, which make the eradication difficult and hence requires more effective treatment. This article discusses the biofilm structure, phenomenon of biofilm formation, signaling, and pathogenicity to highlight the understanding of processes involved in biofilm formation.",book:{id:"11092",title:"Bacterial Biofilms",coverURL:"https://cdn.intechopen.com/books/images_new/11092.jpg"},signatures:"Deepak Dwivedi and Trishla Sehgal"},{id:"81769",title:"Biological Control of Agricultural Insect Pests",slug:"biological-control-of-agricultural-insect-pests",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.104464",abstract:"Pests are highly responsible for heavy crop losses and reduced food supplies, poorer quality of agricultural products, economic hardship for growers and processor. Generally, chemical control methods are practiced for their control which is neither always economical nor effective and may have associated unwanted health, safety and environmental risks. However, to meet the challenge of feeding to the ever increasing human population, an efficient, economical and environment friendly disease control methods are requisites. In this regard, biological control may be an effective means of reducing or mitigating the pests and pest effects through the use of natural enemies. Biological control is an environmentally sound which involves the use of beneficial microorganism to control plant pathogens and diseases they cause. Therefore, in this chapter we will provide a comprehensive account of this environmental friendly approach for effectively management of plant diseases. This chapter will also accentuate the development of biological control agents for practical applications and the underlying mechanism. The contents in the chapter will be beneficial and advantageous to all those working in academia or industry related to crop protection.",book:{id:"11015",title:"Insecticides",coverURL:"https://cdn.intechopen.com/books/images_new/11015.jpg"},signatures:"Mrinalini Kumari, Atul Srivastava, Shyam Babu Sah and Subhashini Sini"},{id:"82474",title:"Vitamin D Deficiency in Childhood Obesity: Behavioral Factors or Altered Metabolism?",slug:"vitamin-d-deficiency-in-childhood-obesity-behavioral-factors-or-altered-metabolism",totalDownloads:9,totalDimensionsCites:0,doi:"10.5772/intechopen.105819",abstract:"Obesity childhood is related to vitamin D deficiency, but the mechanisms for this association still remain questionable. We hypothesized that behavioral factors would be decisive in reducing the body content of vitamin D in patients with obesity. A cross-sectional clinical and analytical study (calcium, phosphorus, calcidiol, and parathyroid hormone) was carried out in a group of 377 patients with obesity (BMI-DS >2.0), 348 patients with severe obesity (BMI-DS >3.0), and 411 healthy children. The place of residence was categorized as urban or rural. Vitamin D status was defined according to the US Endocrine Society criteria. The prevalence of vitamin D deficiency was significantly higher (p < 0.001) in severe obesity (48.6%) and obesity groups (36.1%) than in the control group (12.5%). Vitamin D deficiency was more frequent in severe obesity and obesity groups living in urban areas than in those living in rural areas (not in the control group). The patients with obesity living in urban residence did not present significant seasonal variations in vitamin D deficiency throughout the year in contrast to those patients with obesity living in rural residence. These findings suggest that the most probable mechanism for vitamin D deficiency in children and adolescents with obesity, rather than altered metabolic, is the behavioral factors (sedentary lifestyle and lack of adequate sunlight exposure).",book:{id:"11639",title:"Vitamin D Deficiency - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11639.jpg"},signatures:"Teodoro Durá-Travé and Fidel Gallinas-Victoriano"},{id:"82475",title:"Pharmacological Efficacy and Mechanism of Vitamin D in the Treatment of “Kidney-Brain” Disorders",slug:"pharmacological-efficacy-and-mechanism-of-vitamin-d-in-the-treatment-of-kidney-brain-disorders",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.105820",abstract:"Accumulating evidences have shown that serum 25-hydroxyvitamin D concentrations were inversely correlated with the incidence or severity of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and that vitamin D deficiency might be associated with an increased susceptibility to many of the complications accompanied by COVID-19, such as disorders in kidney and brain. Our previous experimental studies demonstrated that vitamin D and its analogs could protect from kidney diseases, neuroinflammation, and musculoskeletal disorders such as osteoporosis and muscle atrophy, through the suppressive effects on overactivation of the renin-angiotensin system (RAS) in tissues. Moreover, we published a review describing the therapeutic effects of traditional Chinese medicine (TCM) for organ injuries associated with COVID-19 by interfering with RAS. In the TCM principle “Kidney dredges brain,” this chapter will emphasize the potential preventive and therapeutic effects of vitamin D on both renal injuries and central nervous system disorders in COVID-19 patients and further elucidate the pharmacological effects with underlying mechanisms of vitamin D in “Kidney-Brain” disorders.",book:{id:"11639",title:"Vitamin D Deficiency - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11639.jpg"},signatures:"Jia-Li Zhang, Yong-Jun Wang and Yan Zhang"}],onlineFirstChaptersTotal:560},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"June 11th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",isOpenForSubmission:!0,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. 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He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. 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Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:301,paginationItems:[{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",biography:"Professor Nima Rezaei obtained an MD from Tehran University of Medical Sciences, Iran. He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. 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