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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"440",leadTitle:null,fullTitle:"Speech and Language Technologies",title:"Speech and Language Technologies",subtitle:null,reviewType:"peer-reviewed",abstract:"This book addresses state-of-the-art systems and achievements in various topics in the research field of speech and language technologies. 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\r\n\tRecycling is the collection and processing of items that would otherwise be discarded as waste in order to create a new product. Recycled material is being used in an increasing number of today's products. Waste management is primarily concerned with a wide range of wastes, including industrial, biological, household, municipal, organic, biomedical, and radioactive wastes. Human activity, such as the mining and processing of basic resources, generates waste and poses health problems that can emerge both indirectly and directly. Waste mismanagement is a serious problem on an individual and a governmental level. Nowadays, the waste disposal business is both hazy and straining to adapt to globalized consumerism, a system in which things are manufactured on one continent, purchased and used on another, and disposed of on still another. Therefore, remediation is often subject to a variety of legal criteria, but it can also be based on evaluations of human health and environmental concerns in cases where no statutory standards exist or when standards are advisory.
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Saleh and Martin Koller",coverURL:"https://cdn.intechopen.com/books/images_new/6847.jpg",editedByType:"Edited by",editors:[{id:"144691",title:"Prof.",name:"Hosam M.",surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9873",title:"Strategies of Sustainable Solid Waste Management",subtitle:null,isOpenForSubmission:!1,hash:"59b5ceeeedaf7449a30629923569388c",slug:"strategies-of-sustainable-solid-waste-management",bookSignature:"Hosam M. Saleh",coverURL:"https://cdn.intechopen.com/books/images_new/9873.jpg",editedByType:"Edited by",editors:[{id:"144691",title:"Prof.",name:"Hosam M.",surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"45500",title:"Early Continental Rift Basin Stratigraphy, Depositional Facies and Tectonics in Volcaniclastic System: Examples from the Miocene Successions Along the Japan Sea and in the East African Rift Valley (Kenya)",doi:"10.5772/56804",slug:"early-continental-rift-basin-stratigraphy-depositional-facies-and-tectonics-in-volcaniclastic-system",body:'There are numerous stratigraphic studies regarding rift valley fill successions. The major understanding of the rift basins’ filling process was obtained from the Basin and Range regions and Rio Grande Rift, USA (for example, [1-4]); East African Rift Valley (for example, [5-7]); Suez Rift, Egypt (for example, [8-10]); Corinth Basin, Greece (for example, [11-13]) and so on. The initial stage of the rift basin evolution is characterized by the development of a series of small half-grabens. Basins become larger through the linkage of border faults of individual half-grabens [14]. Even after basin mergers, topographic lows of footwall among basins (accommodation zones before basin mergers) play an important role for sediment supply. The relay ramp developed between two normal faults dipping in the same direction (Figure 1), and its evolution, is crucial because it acts as the major entry point of the water and sediments to the basins [14-15]. The manner of sediment entry to the basins and the subsidence pattern strongly affect the architecture of basin-fills (for example, [16-17]), resulting in the formation of different systems tracts in different places within a basin at a given time [18]. In case of continental rift basins with lakes, the strata formation is much more complicated than in marine basins (for example [19-20]). The differences in sedimentation process between lake and marine basins are summarized in [21], suggesting that the terrestrial basin fills are not miniature marine basins because there were different amplitude base-level variations, linkage of climate and sediment supply and so on. Pre-rift basement structures also affect the evolution of the basin as well as fills of the early rift basins (for example, [13, 22-23]).
Various types of linked half-grabens and characteristics of accommodation zones modified from
However, studies of the rift basin fills with active volcanism have been limited and their basin-fill processes are poorly understood (see [24]). Pyroclastic fall may supply sediments from the air nearly evenly within a basin if the basin size is small relative to the pyroclastic fall area. The reworked volcaniclastics (mainly ash) supplied via rivers can be more widely spread in the lake than is the case of the siliciclastic system. This is because of smaller grain density (for example [25]), resulting in faster sedimentation even in parts of a basin starved of sediments transported by streams. Such faster sedimentation may provide opportunities to decode the high-resolution tectonic and basin-fill history through the reconstruction of environmental changes. Some examples of the basin-fill successions affected strongly by sediment supply via pyroclastic fall are, therefore, shown to discuss the evolution of the early rift basin fills. Early rift basins are expected to experience a complicated history in association with merging small basins when border fault tips propagate laterally to the next basin [14] or when one basin is filled out and sediments and water spill over to the next basins beyond the accommodation zone [16]. Examples of studies discussing such events are also limited to a small number [4]. The basins filled rapidly with pyroclastic fall are suitable for detecting such basin-merging events as well as another type of tectonic events such as subsidence.
The Miocene successions exposed along the Japan Sea on the Japanese main island contain the early rift basin fills, which were formed when the Japan Sea was opened; they are now exposed on the land because of tectonic inversion (for example, [26]). One of the basin fills was targeted in this study—the Miocene Koura Formation, exposed in SW Japan. Other targets here were the Miocene half-graben fills in Kenya (Namurungule Formation in Samburu Hills and Nakali Formation in Nakali, northern and central Kenya, respectively). The basin fills adjacent to the volcanoes must be strongly affected by the supply of volcaniclastics and lava flow, as well as subsidence/uplift related to volcanism (for example [24, 27]). However, the local volcano-related tectonics (such as caldera formation) are excluded in this study for simple discussions. Because the centre of the eruption or intrusion of magma during the deposition of the Namurungle and Nakali Formations has not been discovered around the target basins, it is considered that the tectonic subsidence or uplift induced by local volcanisms (see [24, 28]) can be ignored for these cases. The Koura Formation example is unclear for the strong tectonic control from local volcanoes, but its effect can be ignored as well, because lava has not been found and only pyroclastic fall or flow deposits have been described from the formation.
The Miocene successions associated with the Japan Sea opening widely spread along the coastal region of the Japan Sea. The Miocene Koura Formation is exposed in the Shimane Peninsula, on the western part of the main island of Japan (Honshu Island) (Figure 2). The Koura Formation distribution is elongated E–W—which is almost parallel to faults in and around the western Japan Sea (ENE–WSW)—and dips mainly to the north, allowing observation of axial facies changes in the basin (Figure 2). The basin fill thickness exceeds 600 m [29-30]. The basement rock of the basin has not been confirmed yet, but granitic or metamorphic rocks are inferred to be the basement on the basis of the gravels contained in the formation [31].
Location and geologic map of eastern Shimane. 1–7 in
It is difficult to discuss the basin morphology at the time of deposition because of the limited extent of exposure. However, the seismic cross-sections of this area show the presence of a series of half-grabens under the bottom of the Japan Sea [32], suggesting that the Koura Basin fills a half-graben. Although the border fault of this basin has not been confirmed either, one of the major faults of this region, the Shinji Fault (or Kashima Fault), running just south of the distribution area of the Koura Formation (Figure 2) and acting presently as a right-lateral strike-slip fault [33], is most probably the border fault of the basin.
The Koura Formation consists of three members (Sakai et al., 2013). For simplicity, these three members are referred to as “lower”, “middle” and “upper” formations. The lower formation consists of conglomeratic sandstone beds (alluvial fan origin [30]) and the overlying alternation of the sandstone and mudstone beds (meandering and braided streams, floodplain, marsh and shallow lake origin [34]) (Figures 3 and 4). The middle formation consists of andesitic volcaniclastics deposited in a shallow (probably fresh) lake and floodplain (Figures. 3 and 4). The sediments in this interval are predominated by those from pyroclastic fall and small-scale gravity flows (Kano, 1991; Sakai et al., 2013). The upper formation is characterized by alternations of tuffaceous sandstone and mudstone beds (fan delta deposit; Figures 3 and 4) and conglomerate interbeds filling small sublacustrine channels developed on the fan delta slope —which were deposited in a blackish lake, as suggested by the presence of
Lithostratigraphy of the Koura and lowest Josoji Formations. T3–T5 indicate lapilli tuff beds in the upper Koura Formation.
Columnar cross-sections of the Koura Formation (modified from [
The boundaries of the lower-middle and middle-upper formations are marked by a surface that is then overlain by an up to 10 m sediment interval consisting of cross-stratified sandstone or conglomerate beds (Figure 5). It is interpreted that each cross-stratified interval was deposited from a basin-wide flood-flow incoming from another basin, and subsequent lake-level rise occurred when this and the other basin were merged [34], on the basis of the following reasons: (1) absence of a major erosion surface within both cross-stratified intervals and homogeneous lithology imply their deposition within a short period; (2) both the cross-stratified intervals cover terrestrial deposits with tree trunks, and change upward into the alternations of sandstone and mudstone bed and the andesitic volcaniclastic beds containing both pyroclastic fall, turbidite and beds with small-scale slump structures (lake deposit) (Figure 5). The rapid lake-level rise suggests the merger with a basin having a base level higher than that of the Koura Basin. The second event may record the merger of this basin with a marine one to become a blackish lake basin.
Columnar cross-sections of the event beds. Each event bed is interpreted as having been deposited from an outburst flood associated with a basin merger, followed by a lake-level rise (modified from [
The top of the Koura Formation is marked by a major flooding surface below the black marine shale of the Josoji Formation. The Josoji Formation is interpreted to consist of sediments of the climax phase of the Japan Sea opening. In the context of sequence stratigraphy, the lower and middle formations are interpreted to be the lowstand systems tract (LST). The base of the upper formation is interpreted to be the first flooding surface and the upper formation is interpreted to be the transgressive systems tract (TST) together with a part of the overlying Josoji Formation.
The upper Koura Formation hosts sediment cycles (Figure 6). The thickness of each cycle ranges from 5 to 20 m. Some of the cycles are bounded by flooding surfaces (see [40]) (Figure 6A). Such cycles mainly consist of sediments with an upward-shallowing trend. The basal flooding surface is covered with a massive mudstone bed (outer shelf equivalent deposit of the fan delta) or an alternation of HCS sandstone and mudstone beds of inner shelf equivalent deposits of the fan delta [34]. On the other hand, most of the cycle bases are represented by a surface covering a slumped deposit (Figures 6B–D). Each surface is undulating (i.e. erosional) (Figures 6B and 6D), and is then covered with facies beds shallower than those below the surface (Figure 6). Parts of the sediments just above the surface are also dragged into the slumped deposits in some places (Figure 6C), indicating that sediment accumulation above the surface occurred almost simultaneously with slumping. The sediment overlying the surface is then punctuated by the flooding surface (Figure 6), covered by a shallowing-upward succession. The cycle boundaries are, therefore, interpreted to have been formed by relative uplift of this area at the time of deposition.
Columnar cross-section of a part of the upper Koura Formation and changes in depositional environment. A: a sediment cycle showing an upward-shallowing trend. The cycle base is represented by a flooding surface. B: an erosion surface truncating the inner shelf equivalent deposit, and is then covered with HCS sandstone beds of the shoreface origin. s.b.: slump block. Note the hammer for the scale. C: a close-up photograph of the sediment just below the erosion surface (cycle boundary). There are several slip surfaces of the slump in the sediments. Coarse-sediment grains, which can be found only above the surface, are also incorporated (probably dragged) into the slumped horizon. The scale is 0.2 m long. D: a basal erosion surface of the cycle, truncating the inner-shelf-equivalent deposit and being covered with fluvial channel deposit. The white arrow indicates the surface. See
Such sediment cycles were not identified in the lower and middle formations. The detailed outcrop observations in the lower formation revealed that either the top or the base of the sandstone intervals (fluvial channel facies) is marked by a surface associated with minor sliding (Figure 7); the former case is the most common (Figure 7). The surface is then covered with a thin poorly sorted silty sandstone bed (up to 0.1 m thick)(Figure 7A). Some of the silty sandstone beds contain pebble-sized sandstone or mudstone clasts of the underlying beds (Figure 7). In some places, the very small syndepositional faults extending almost parallel to the bedding plane are recognized below the silty sandstone beds. The silty sandstone beds are then covered with a massive or a laminated mudstone bed of a small and shallow lake origin (Figure 7B), showing a lake-level rise immediately after the sliding event. The slide may have been associated with subsidence of the basin.
Example of the columnar cross-section of the lower Koura Formation taken along section 6. The arrows indicate the horizons showing evidence of a small-scale slide. A: outcrop view of the fluvial deposit. The arrow indicates the horizon of
In the Kenya Rift, the Miocene rift basin-fill successions are exposed (Figure 8). The activity of the rift system started in the Oligocene and attained its maximum in the middle to late Miocene [41]. We targeted the half-graben fills exposed in the Samburu Hills, northern Kenya [42-44], and Nakali, central Kenya [45]. The target sediment successions of both areas (Namurungule and Nakali Formations) have not been classified into members based on the international stratigraphic nomenclature, although each formation can be divided into three units. Therefore the terms, the lower, middle and upper formations, are used for three units of each formation in the present study.
Location map of Samburu Hills and Nakali in central and northern Kenya.
Samburu Hills
Samburu Hills are located in the eastern shoulder of the eastern branch of the East African Rift Valley system, northern Kenya (Figure 8). The Nachola, Aka Aiteputh, Namurungule and Kongia Formations (ca. 20–5.3 Ma [43]) make up the Miocene succession, which covers the Precambrian Mozambique Belt rocks (gneiss and granitic rocks)(Figure. 9). The upper Aka Aiteputh to the Namurungule Formations’ phase (ca. 10–9.3 Ma) was one of the major rifting periods in this area, as suggested by the development of a series of small half-grabens, which is indicated in the geologic map as the scattered distribution of the Namurungule Formation [42] (Figure 9). Each formation body has a lenticular plan view and one or both sides of the body are punctuated by faults (Figure 9).
Geologic map of the Miocene in Samburu Hills. The enclosed part is the studied area. KI1, KI2, NM2 and NK5 are locations of columnar cross-sections in
The target basin has a lenticular shape extending N–S (Figure 9). Although the western margin of the basin is truncated by the overlying Kongia Formation— which is interpreted as having been deposited during the rejuvenated phase of the rift after 7 Ma (see [43])—the border fault of the basin runs in the western margin, as suggested by the Namurungule sediments thickening to the west [42]. There is a gap in fault location in the northern and southern halves of this basin. In the earliest phase of basin evolution, there may have been an accommodation zone in the boundary between the northern and southern halves of this basin.
The northern half of the basin, where spectacularly well exposures allow sediment correlation among outcrops, was targeted in the present study. A half-graben fill consists of the upper Aka Aiteputh Formation, which is characterized by red soil beds with abundant calcrete layers and basalt lavas with basalt conglomerate layers [44]. The overlying Namurungule Formation consists of four parts: the basal conglomerate beds of alluvial fan origin, the alternations of tuffaceous mudstone and sandstone beds (mudstone-dominated) of the lower part (both parts form the lower formation) and an about 20-m-thick lahar deposit of the middle formation (Figure 10). The upper formation is represented by a pile of sediment cycles, each of which consists of a sandstone-dominated and an overlying mudstone-dominated interval, as mentioned below. The age of the Namurungule Formation ranges from 9.6 to 9.3 Ma [43], and the rapid sedimentation rate was estimated to be 1.52 m/ky for the lower formation and 0.24 m/ky for the upper formation [42].
Columnar cross-sections of the Namurungule Formation (modified from [
From the viewpoint of sequence stratigraphy, the red soil beds and basalt lava interval of the upper Aka Aiteputh Formation and alluvial fan interval of the basal Namurungule Formation are interpreted as the LST; most of the lower Namurungule Formation, except for its basal and uppermost part, is the TST showing retrogradational succession. The remaining part is the highstand systems tract (HST) (Figure 10: see also [44]).
The TST is characterized by a rapid lateral facies change from the thick lake facies in the southern part to the terrestrial facies represented by the alternations of root-bearing mudstone and sandstone beds in the northern part. The up to 20-m-thick terrestrial sediments in the TST contain a few stream deposits represented by an up to 0.5 m of sheet sandstone beds with parallel and trough cross-stratification. Other sandstone beds in the terrestrial deposits are associated with temporary lake expansions, as suggested by the wave-generated sedimentary structures (wave ripple lamination and small hummocky cross-stratification) in sandstone beds [42] (Figure 11). There are local slide deposits, represented by pebble- and cobble-sized mudstone breccia in the succession (Figure 11).
Example of the columnar cross-sections from the lower Namurungule Formation (modified from [
On the other hand, the HST is represented by a pile of sediment cycles [42]. Each cycle consists, from the base to the top, of the conglomeratic sandstone beds of fluvial channel fill origin, root-bearing mudstone beds of floodplain origin, laminated mudstone beds of lake origin and tabular cross-stratified sandstone beds of delta front origin (Figure 12). The cycle boundaries are sharp and undulating, and truncate the underlying sediments (delta front and lake deposit) (Figure 12).
Example of the columnar cross-sections from the upper Namurungule Formation (modified from [
Individual cycles tend to thicken to the west, which are interpreted to be owing to tectonic subsidence in the western part of the basin. The basal surface truncates the underlying sediments in each cycle, indicating a lake-level fall probably because of the migration of lake water to the basin centre when the basin subsidence occurred (for example, [2]).
Petrographical analysis indicates that the sediments (feldspar and rock fragments, mainly basalt grains) were supplied only from the adjacent area during the deposition of the upper Aka Aiteputh and lower Namurungule Formations (Figure 10), showing the poor development of the drainage system. On the other hand, the sediment grains in the upper formation supplied from the basement (Mozambique Belt), such as quartz and microcline, suggest that the drainage basin became wider through time [46]. This trend, later appearance of the grains originating from basement rocks, has been reported from other rift basins (for example, [46]).
Miocene Nakali Formation
Nakali is located about 50 km south of the Samburu Hills (Figure 8). The Miocene Nakali and Nasorut Formations are distributed in this area [45] (Figure 13). The lower part of the lower Nakali Formation is characterized by the alternations of tuffaceous sandstone and mudstone beds, which are interpreted to be turbidite and slumped deposits (delta front deposit), and the overlying thick lapilli tuff beds that bury the lake (Figure 14). The fluvial channel fill, floodplain and shallow lake deposits (conglomerate, tuffaceous sandstone and mudstone beds) characterize the upper part of the lower formation. The middle formation is represented by thick pyroclastic flow deposits (ca. 40 m). The lower part of the upper formation shows sediment characteristics similar to the upper part of the lower formation. The upper part of the upper formation is represented by tuffaceous mudstone beds and conglomerate and sandstone interbeds with slump structures. The slumped deposits in this interval indicate that this is of the lake slope origin (Figure 14). One of the important hominoid fossils,
Geologic map of the Nakali Formation (modified from [
The generalized litho- and chronostratigraphy of the Nakali and Nasorut Formations (modified from [
Two normal faults extending N–S separate the rocks of this formation into three blocks (eastern, central and western) (Figure 13). The displacement of the eastern fault is larger than those of the others and is estimated to be about 200 m on the basis of the altitude gap of the middle formation between the eastern and central blocks.
Subsidence history of the upper Nakali formation
The good exposures of the lower part of the upper formation and the frequently interbedded tuff beds allow observation of lateral facies changes in the field within and among blocks (Figure 15). Six tuff beds were identified in this horizon, and are named Twin (two white tuff beds), Exo (white tuff bed containing abundant trachyte fragments), Pum (pumice tuff), Fu (poorly sorted pumice tuff bed), Mfu (poorly sorted pumice and accretionary lapilli tuff bed) and Ma (white tuff bed containing accretionary lapillis) (Figure 15). The thick cemented beds with weakly weathered soil beds (termed ‘terrace forming bed’ in Figure 15, because this bed forms a wide terrace in this place); the White beds, represented by the sandstone and conglomerate beds rich in small breccia of white tuff, and the Red beds, characterized by red conglomerate and sandstone beds of fluvial channel fill and floodplain origin (Red beds), can be used for the correlation as well. The bases of the lake deposits, flooding surfaces, were also used as one of key horizons (Figure 15).
Columnar cross-sections of the lower part of the upper Nakali Formation. The black bar indicates the horizon of lake deposit. The dotted and solid lines indicate correlated tuff beds and flooding surface, respectively. A bold line indicates “the terrace forming bed”. See text for tuff names. F: local flooding surface.
The correlation results (Figure 15) show thicker sediments in the western part of the central block below the Twin Tuff bed. The thickness of sediments between the base of the upper formation and Twin Tuff bed consistently increases from section 5 to section 2, even though section 2 is located in the west of the fault separating the western and central blocks. This may show that the fault was inactive before the Twin Tuff deposition, and another fault, which is not indicated on the geologic map and is running west of the study area, was active instead.
Thickness of the sediments between the Twin and Pum Tuff beds is almost constant in the central block. However, the Red beds tend to be thicker to the east, and the sediments between the local flooding surface (F in Figure 15) and Exo Tuff bed tend to be thicker to the west, suggesting a temporary seesaw subsidence during the deposition between the Twin and Pum Tuff beds (Figure 15).
The sediments above the Pum Tuff bed (Figure 15) tend to be thicker in the eastern part of the central block. This thickness change and the appearance of the thicker lake deposits in the eastern part clearly indicate that the depocentre was shifted in the eastern part of the basin. The seesaw subsidence seems to have ceased just before the Pum Tuff deposition. The thicker sediments to the east indicate that the fault separating the central and eastern blocks may have been formed in this phase. Note the thickness variation between the Pum and Ma Tuff beds—which tend to be thicker from section 3 to 5, but have thicker sediments in the same horizon in section 1, indicating larger subsidence around section 1 than section 3. This suggests that the fault separating the central and western blocks also became active after the Pum Tuff bed deposition.
Such a seesaw subsidence pattern suggests that the study area was located on the accommodation zone [3, 5] during the deposition of the lower part of the upper Nakali Formation. The Case C fault linkage and accommodation zone proposed in [5] (Figure 1) is inferred for this case.
Seesaw subsidence was reported from the Santo Domingo Basin in the Rio Grande Rift system [3], which has been long lived from the Oligocene to Pleistocene, because of changes in the shift of the active part of the faults forming the accommodation zone. This study showed a gradual facies shift because of such long-term seesaw subsidence (Figure. 8 in [3]). In case of the Nakali Formation, the movement’s scale is much smaller and shorter than the case in [3]. This seesaw subsidence may have been related to the development of the block-bounding faults, which propagated either from the south or north. Such a temporary seesaw subsidence pattern may be the typical subsidence pattern of the Case C accommodation zone (Figure 1) when the zone is incorporated into a larger basin because of the merger of smaller basins. This result additionally suggests that the constant thickness sediments within a half-graben fill could be the consequence of the seesaw subsidence happening in a short period.
Samburu Hills provide a good example of a basin that was strongly controlled by sediment supply from pyroclastic fall. The target basin did not seem to experience a complicated tectonic history during the Namurungule phase (interaction with another basin, such as a basin merger) like other examples, so it is a suitable place to discuss the contribution of fine volcaniclastics supplied by falls or streams on stratigraphic architectures. Because the border fault of this basin runs along the centre of the rift basin, sufficient sediment supply from the footwall slope would not have been expected, and the basin should have been starved in terms of sediment supply (particularly siliciclastic sediments). However, the supply by pyroclastic fall or by streams that transported reworked pyroclastic fall sediments to the lake contributed to the high rate of sedimentation. The total thickness of the lake deposit (TST) at the southern end of the study area becomes almost double that at the northern end of the basin. This suggests that the newly formed accommodation space was rapidly filled even near the basin centre.
The presence of different systems tracts within a half-graben in the same period was expected on the basis of computer simulations [18]. The study simulated marine basins, but its results are also applicable to continental basins, except for a different response of the lake- or sea-level changes compared with the tectonic subsidence (see [21]). As expected in [18], a high rate of sediment supply might have resulted in a progradational stacking pattern in the northern end of the target basin, where the subsidence rate was small. The absence of the progradational unit in this place can be explained by dispersion of the eroded sediments into the basin due to the larger mobility of fine volcaniclastics. However, we need more tests to evaluate the effect of the higher mobility of volcaniclastics compared with siliciclastic sediments on the stratigraphic architecture.
Another two basin sediments (Koura and Nakali Formations) were dominated by volcaniclastics, and show high sedimentation rates [44-45]. The high-resolution tectonics related to basin evolution are discussed as follows.
Both Koura and Nakali Formations record that terrestrial or shallow lake environments were finally changed to deep-water environments (Figures. 4 and 14) after several periods of rapid environmental change. As mentioned in Sakai et al. (2013), it is highly possible that the Koura Formation experienced at least two periods of outburst floods and subsequent lake-level rise as a result of merging basins.
The major flooding surface of the upper Nakali Formation is also interpreted as having been associated with a basin merger event. The hummocky cross-stratified beds and conglomeratic sandstone interbeds just below the flooding surface may be a record of strong waves and currents just before this basin was deeply submerged (Figure 16). Another basin merger event is expected to have occurred when the subsidence centre jumped from the western to eastern part of the central block around the deposition of the Pum Tuff bed. However, distinct evidence of basin merger cannot be found in the sediments. This was probably because of lower topographic relief in the accommodation zone (Figure 1), which was not high enough to cause the major shift in lake water when two basins were merged.
Example of the columnar cross-section of the upper formation, showing the boundary of the upper and lower halves of the upper formation. A concave-up solid line indicates an erosion surface. A: outcrop photograph of the boundary of the lower and upper halves of the formation. B: close-up photograph of the boundary. HCS: hummocky cross-stratification, cgs: conglomerate beds, s: slope deposit. C: an example of the slumped beds in the upper half of the upper formation. b: large slump block.
The process of the basin merger and related basin fill has been modelled in some previous studies [4, 16], which emphasized the hydraulic connection between two adjacent basins after one basin reached the over-filled condition (see [19]). In the present examples (Koura and Nakali cases), each event seems to have been related to the outburst flood and associated with a rapid deepening event. Both basins finally submerged into the Japan Sea or deep lake in short periods, implying a high subsidence rate in these basins. Therefore, the tectonic merger of the basins (i.e. connection of border faults of adjacent basins) is strongly expected for these cases. Because the Japan Sea was opened rapidly during the middle Miocene, evidence of such basin mergers is expected to be found from many basins along it.
In the Namurungule and Koura Formations, sediment cycles appear in their upper parts[34, 44]. Similar types of cycles have been reported from other areas, and some of the cycle formation was explained simply by migration of the fluvial system ([47]). Strong pulse of pyroclastic sediment supply could form small cycles as well. The Namurungule case, thickening of individual cycles to the west, indicates that the cycle formation is controlled by subsidence within the basin [42].
The Koura Formation example shown here is only a one-dimensional section, and is not enough to discuss the origin of the cycles. However, some of the erosion surface formation is clearly associated with tectonics. The shallower facies covering basal cycle surfaces without sedimentation gaps (Figures 6B and 6C) implies a lake-level fall induced by a relative uplift against the basin centre around the measured section. Although it is impossible to know the quantity of the relative uplift, the estimated uplift might be a few metres on the basis of the facies gap above and below the surface. The formation of the flooding surface and some of the cycle boundaries may be related to eustatic sea-level rise and fall.
On the contrary, both formations do not contain such cycles in their lower and middle parts. The lower parts of both formations, however, show evidence of small-scale sliding in the sediments (Figures 7 and 11). There is a small gap in the environment above and below the slide interval of the lower Koura Formation, indicating that a small-scale subsidence occurred. However, the subsidence was not of sufficient amplitude to form a cycle boundary like the case of the upper formation.
This matches with the general understanding of the rift basin evolution, where the displacement of the border fault becomes larger through the basin enlargement (for example, [14, 16]). The absence of the poorly developed drainage system also contributed to the absence of sediment cycles in case of the Namurungule Formation, because streams do not have enough strength to form an erosion surface when the relative uplift occurred. Therefore, the earliest phase of the rifting is not favourable for generating small sediment cycles related to tectonics because of smaller fault displacement.
The Nakali Formation does not contain such small sediment cycles, which indicates that the uplift or subsidence associated with fault displacement was not distinct in this place. Because the area we observed may have been situated near the accommodation zone when the upper formation was deposited, the fault displacement causing subsidence/uplift may have been smaller than that near the basin centre and was not enough to form sediment cycles.
Three examples of the early rift basin fills from the Koura Formation in SW Japan, and from the Namurungule and Nakali Formations in central and northern Kenya, have been indicated. The three basin fills consist mainly of volcaniclastics and are represented by rapid sediment accumulation. The Namurungule Formation’s succession may be strongly affected by the wide dispersal of volcaniclastics in the lake resulting in a single systems tract within the basin, although a progradational unit is expected to be formed from the marginal part of the basin with a smaller subsidence rate during the TST formation in the central part of the basin. The longer-lived Koura and Nakali Basin fills may record basin merger events followed by lake-level rises probably associated with tectonic basin mergers. The appearance of the cycles only in the upper part of the Koura and Nakali Formations is interpreted to have been associated with the larger displacement of the border faults than when their lower and middle parts were deposited. Absence of the cycles in the lower part of the upper Nakali Formation can be explained by insufficient relative uplift/subsidence of the basin for cycle formation.
We thank Dr Y. Itoh of the Osaka Prefecture University and Dr O. Takano of JAPEX, who gave us the opportunity to submit this manuscript to this publication. Research in Samburu Hills and Nakali was permitted by the Government of Kenya and was supported by many local people. This study was supported by a grant in aid from the Ministry of Education, Japanese Government (17740335 for TS, 19207019 for MN and 14253006 for YS).
Orthodontic developments, especially during the last years, have been accompanied by a significant increase in the esthetic demands of the patients [1]. With the significant recent improvements in computer-aided design/computer-aid-ed manufacturing (CAD/CAM) and dental materials, there has been an increase in the demand for plastic systems [2]. Clear aligners provide an esthetic and comfortable treatment experience, facilitate oral hygiene, cause less pain as compared to fixed orthodontic appliances, and reduce the number and duration of appointments [3, 4, 5]. The aligner therapy also involves a lower incidence of demineralization, enamel abrasion, periodontal lesions, and mucosal irritations [6].
The concept of clear aligners was introduced by Kesling in 1946 with a tooth positioner fabricated by thermoplastic material molding technology and designed for minor tooth movements during the finishing stages of orthodontic treatment. In 1993, Sheridan and colleagues developed a technique of giving new clear retainers to the patient at each visit, incorporating interproximal reduction to provide the necessary space for tooth movement [3, 7]. With further advancement in orthodontic technology, Align Technology introduce the clear aligner treatment (CAT) rendering Kesling’s concept a feasible orthodontic treatment option [8]. A series of removable polyurethane aligners were introduced as an esthetic alternative to fixed labial appliances. Scanned images are converted to physical models by using different stereolithography (STL) techniques to fabricate a series of aligners that sequentially reposition the teeth. Each aligner is programmed to move a tooth or a small group of teeth 0.25–0.33 mm every 14 days [9, 10]. Align Technology provides orthodontists with ClinCheck (Align Technology Inc., Santa Clara, Calif) models, which reflect the treatment outcomes. The aligners incrementally shift the teeth into place based on the outcome the orthodontist expects to achieve [11].
The primary focus of the clear aligner system was initially to solve cases of low and moderate crowding and to close small spaces [1]. However, it has continually evolved through the development of new aligner materials, attachments on teeth, as well as new auxiliaries, such as “Precision Cuts” and “Power Ridges” to address a wider range of malocclusions and to enable additional treatment biomechanics [2, 5, 12].
Despite the available body of literature pertaining to aligner technology, only a few investigations have focused on the efficacy of clear aligner therapy in controlling orthodontic tooth movement. Furthermore, the stability after treatment has not been thoroughly investigated.
The purpose of this chapter was to update the knowledge of the available evidence about effectiveness and stability of clear aligners and to answer the following clinical research question: “Are clear aligners effective in controlling the orthodontic movement in non-growing subjects and what about stability of this treatment modality?”
A systematic search in the medical literature produced between January 2015 and January 2021 was performed to identify all peer-reviewed articles potentially relevant to the review’s question.
The following databases have been used: CENTRAL, MEDLINE, MEDLINE in Process, Embase and Cochrane Library databases.
The search strategy comprised use of the following terms: (invisalign OR clear aligners OR aligners OR transparent aligners) AND (effectiveness OR efficacy) AND (dental changes OR treatment outcome) AND (stability).
Additionally, a manual search was conducted in orthodontic journals of interest, such as The Angle Orthodontist, the American Journal of Orthodontics and the European Journal of Orthodontics. Title and abstract screening was performed to select articles for full text retrieval.
The following inclusion and exclusion criteria were used:
Study design: meta-analysis, systematic reviews, randomized and non-randomized clinical trials, prospective and retrospective studies were included.
Participants: non growing patients.
Intervention: articles that studied dental movement of cases treated with clear aligners.
Results: the efficacy of clear aligners in performing dental movements and the stability of treatment, superimposing virtual models or radiographs.
We excluded for our study articles older than 6 years, samples with growing patients, articles written in a language other than English, in-vitro studies, author opinions, letters to the editor, isolated cases, series of cases, surgical cases, or reports of patients with syndromes.
The grading system described by the Swedish Council on Technology Assessment in Health Care (SBU) [13] was used to assess the methodological quality and the level of evidence of the articles (Tables 1 and 2).
Grade A—high value of evidence |
All criteria should be met: |
Randomized clinical study or a prospective study with a well-defined control group |
Defined diagnosis and endpoints |
Diagnostic reliability tests and reproducibility tests described |
Blinded outcome assessment |
Grade B—moderate value of evidence |
All criteria should be met: |
Cohort study or retrospective case series with defined control or reference group |
Defined diagnosis and endpoints |
Diagnostic reliability tests and reproducibility tests described |
Grade C—low value of evidence |
One or more of the conditions below: |
Large attrition |
Unclear diagnosis and endpoints |
Poorly defined patient material |
Swedish Council on Technology Assessment in Health Care (SBU) criteria for grading assessed studies.
Level | Evidence | Definition |
---|---|---|
1 | Strong | At least two studies assessed with level “A” |
2 | Moderate | One study with level “A” and at least two studies with level “B” |
3 | Limited | At least two studies with level “B” |
4 | Inconclusive | Fewer than two studies with level “B” |
Definitions of evidence level.
The selection of articles included in this review is shown in the PRISMA flow chart (Figure 1). Study selection procedure was comprised of title-reading, abstract-reading, and full-text-reading stages. After exclusion of not eligible studies, the full report of publications considered eligible for inclusion by the authors was assessed. Eleven studies were included in the qualitative synthesis.
Flow chart according to the PRISMA statement.
Of the eleven included articles, there were five retrospective studies [6, 14, 15, 16, 17], two prospective studies [7, 11], two randomized controlled trials (RCT) [18, 19], two systematic reviews [2, 20] and one meta-analysis [20]. Most of the included studies evaluated mild to moderate malocclusions except for one [17] that involved first premolar extraction cases. The majority of studies used the Invisalign® system except two studies that used Nuvola® system [15] and F22 aligners [14].
Data collected from each of the included articles are described in Tables 3 and 4. Nine of the covered studies assessed predictability of tooth movements comparing post-treatment patient models to the predicted digital planned tooth movement models [2, 6, 7, 11, 14, 15, 16, 17, 18]. Two studies assessed the stability of the clear aligner therapy [19, 20].
Study | Study design | Participants | Intervention | Results |
---|---|---|---|---|
Buschang et al. 2015 [11] | Prospective clinical trial | 27pts |
|
|
Lombardo et al. 2017 [14] | Retrospective case series | 16 pts. F22 aligners |
|
|
Tepedino et al. 2018 [15] | Retrospective case series | 39 pts. First phase of treatment made of 12 aligners by Nuvola® aligner system |
|
|
Charalampakis et al. 2018 [16] | Retrospective case series | 20 pts. Class I patients treated with Invisalign and needed refinement |
|
|
Lopez et al. 2019 [2] | Systematic review | 20 studies |
|
|
Dai et al. 2019 [17] | Retrospective case series | 30 pts. First premolar extraction treatment with Invisalign |
|
|
Zhou et al. 2020 [7] | Prospective clinical trial | 20 pts. arch expansion with Invisalign aligners |
|
|
Al-Nadawi et al. 2020 [18] | Randomized clinical trial | 80 pts. three aligner wear protocols: 7 day, 10 day, and 14 day. |
|
|
Riede et al. 2021 [6] | Retrospective case series | 30 pts. Aligner treatment (Invisalign®) with the current material (SmartTrack®) |
|
|
Design, participants, type of intervention, and results of studies included in the qualitative analysis.
pts, patients; OGS, Objective Grading System; IPR, interproximal reduction; CBCT, Cone beam computed tomography.
Study | Study design | Participants | Intervention | Results |
---|---|---|---|---|
Zheng et al. 2017 [20] | Systematic review and meta-analysis |
| Scientific evidence |
|
Graf et al. 2021 [19] | Double-center trial | 33pts |
|
|
Studies assessing treatment stability of clear aligners.
pts, patients.
According to the SBU tool (Tables 1 and 2), among the selected studies, the methodological quality was low for four studies [6, 11, 16, 17], moderate for four others [7, 14, 15, 19] and high for one study [18] (Table 5). Thus, conclusions with a moderate level of evidence could be drawn from the review process.
Study (first author, year) | Evidence level |
---|---|
Buschang, 2015 [11] | C |
Lombardo, 2017 [14] | B |
Tepedino, 2018 [15] | B |
Charalampakis, 2018 [16] | C |
Dai, 2019 [17] | C |
Zhou, 2020 [7] | B |
Al-Nadawi, 2020 [18] | A |
Riede, 2021 [6] | C |
Graf, 2021 [19] | B |
Evidence grade according to Swedish Council on Technology Assessment in Health Care.
In this review, we aimed to provide data on the effectiveness and stability of treatment with clear aligners. The level of evidence was moderate as we identified one study with level «A» and four studies with level «B».
The effectiveness of clear aligners was judged by the predictability of tooth movement which varies with the type of tooth and the type of movement. Lopez et al. [2] found that the expression of the programmed movement was not fully accomplished with Invisalign®.
Concerning
Many studies showed that intrusion was the most unpredictable movement especially for the maxillary central and lateral incisors [16, 21]. Invisalign has a bite-block effect, because 2 aligners of 0.38-mm width are interposed between posterior teeth throughout treatment. Unexpected intrusion of the molars would cause the incisors to appear extruded on the posttreatment models after superimposition [16]. In fact, according to Grunheid et al. [22], mandibular incisors tend to be positioned more occlusally than predicted. The bite-block effect may make open bites easier to treat with Invisalign [16].
Concerning
Molar distalization was recorded as the highest accuracy with no need for attachments. Simon et al. [25] also reported a high accuracy (88%) of the bodily movement of upper molars when a distalization movement of at least 1.5 mm was prescribed.
Several studies agreed that derotation of rounded teeth especially canines was difficult to achieve with aligners [16, 22, 26]. An amount of rotation greater than 15° has been identified as a risk factor for decreased accuracy for rotational prediction [25]. Interproximal contacts of rotated canines might also be considered a significant predictor for the diminished efficacy of tooth movement, especially in the absence of interproximal reduction of the enamel (IPR) [26]. The direction of derotation has been also documented to influence the accuracy of the maxillary canine, with distal movement demonstrating less accuracy than mesial [21]. This is possibly due to the actual contact area between canine and premolar and the potential challenges of providing enamel reduction in this area.
It has been recommended to plan overcorrections, especially if rotations exceed 15°, to use attachments, and to reduce staging to less than 1.5° per aligner [8, 16, 25]. However, although various types or shapes of attachment grips or practices of interproximal enamel reduction have been reported as potential prognostic factors for better efficacy of rotational tooth movement, this does not necessarily translate into an identified substantial effect in practice [26].
Concerning
According to Lopez and al. [2], Invisalign® was also able to alter intercanine, interpremolar, and intermolar width in the presence of crowding. Kravitz et al. [23] recommended to treat cases with severe lower crowding mostly by interproximal reduction (IPR) instead of dentoalveolar expansion. This recommendation comes from the finding that retraction is more accurate than dentoalveolar expansion of the lower anterior teeth. The expansion of the mandibular intercanine width also poses the greatest risk of relapse following treatment [29].
Concerning the effectiveness of the occlusal contacts with clear aligners, the study by Izhar et al. [10] found that the software models do not accurately reflect the patient’s final occlusion immediately at the end of active treatment. Kassas et al. [30] also stated that clear aligners were not sufficient for providing ideal occlusal contacts. The deterioration in occlusal contacts was caused by the thickness of aligners, which interferes with the settling of the occlusal plane.
As far as the malocclusion type is concerned, the study by Graf et al. [19] showed that Invisalign® treatments are able to significantly reduce malocclusions in adult patients. The study found that all types of sagittal malocclusion (class I, class II, and class III) were ‘greatly improved’ with a rate of 77.44%. Graf and al. [19] also concluded that conventional attachments and the combination with optimized attachments equally led to treatment effectiveness regarding the total PAR score reduction with equally achieved effectiveness in mild, moderate, and rather severe cases. However, for Class II malocclusion, Patterson et al. [31] reported that there was no significant Class II correction or overjet reduction with elastics for an average of 7-month duration in the adult population. Additional refinements may be necessary to address problems created during treatment mainly posterior open bite.
One study of our review by Dai et al. [17] assessed the effectiveness of Invisalign in first premolar extraction treatment. According to this study, first molar anchorage control and central incisor retraction were not fully achieved as predicted. Only medium anchorage control was achieved as the first molars actually moved mesially. The G6-optimized attachment showed similar control in first molar angulation and mesiodistal translation as did 3- and 5-mm horizontal rectangular attachments. On the other hand, setting a distal tipping of 6.6 mm on the first molars might help clinically maintain the tooth angulation, leading to bodily tooth movement. According to the same study [17], the incisors inclined lingually under the retraction force. Accordingly, the use of power ridges or attachments as well as overcorrection by setting greater buccal crown inclination during the virtual setup should be considered to achieve optimal incisor torque control.
Current evidence does not support the clinical use of aligners as a treatment modality that is equally effective to the gold standard of braces [32]. However, clear aligners have advantage in segmented movement of teeth and shortened treatment duration, but are not as effective as braces in producing adequate occlusal contacts, controlling teeth torque, and retention [5, 33].
Many variables influence the accuracy of dental movements, but very few studies have analyzed these parameters in treatments with clear aligners. According to Tepedino et al. [15], several factors determine successful tooth movement such as the attachment’s shape and position, the aligner’s material and thickness, the amount of activation present in each aligner, and the techniques used for the production of the aligners. Treatment outcomes depend also on the patient’s characteristics, bone density and morphology, crown and root morphology of the teeth, as well as on factors related to the clinician. Orthodontists have to incorporate their expert knowledge in determining proper sequencing of tooth movements, tooth attachment design and placement, and prescribing overcorrection when needed for difficult tooth movements to increase efficiency and achieve better treatment outcomes [22, 34]. Patient compliance is also mandatory to achieve good results by wearing the aligners 22 hours a day or more [28].
One study from this review with a high level of evidence [18] evaluated the impact of wear protocol on the accuracy of clear aligners. It has concluded that fourteen-day changes were statistically significantly more accurate in some posterior movements mainly maxillary intrusion, distal-crown tip and buccal-crown torque, and in mandibular intrusion and extrusion.
As in all types of orthodontic treatment, stability is one of the most important issues to discuss regarding clear aligners. According to the systematic review by Zheng et al. [20], only one study compared the post-retention dental changes between patients treated with Invisalign and those treated with conventional fixed appliances. They found that the change in the total alignment score in the Invisalign group was significantly larger than that for the Braces group. There were significantly larger changes in maxillary anterior alignment in the Invisalign group than in the conventional bracket group. Tamer et al. [5] also reported that maxillary anterior leveling relapsed in the Invisalign group. On average, the posttreatment models lost twice as many points for alignment than the respective ClinCheck models. In other words, a full finishing phase of treatment may be needed to achieve the results indicated in the ClinCheck model [11].
The type and degree of tooth movement, the duration of active treatment and the retention protocol are among major influencing factors of posttreatment stability and relapse. The study by Graf et al. [19] is the first one to assess the stability of clear aligners outcome throughout a retention period of 10 months. The retention protocol involved a mandibular multistrand fixed retainer (0.0155 inch; stainless steel, 24 K gold plated) bonded on each lingual surface from canine to canine and a removable modified Hawley retainer for the upper arch (with mandatory Adams clasps on first molars). The study showed that the treatment outcome can be stable throughout this retention protocol. It has also concluded that treating patients with respect to their physiological boundaries and maintaining their original arch form would be key to treatment stability. Overexpansion of the dental arch, especially in the lower arch and in adult patients, is a potential risk for stable results.
There is current evidence with a moderate level of certainty regarding the effectiveness of clear aligner therapy for certain tooth movements. Clear aligners can safely straighten dental arches in terms of leveling and derotating the teeth, except for canines and premolars. The crown tipping can be easily performed. However, important limitations include arch expansion through bodily tooth movements, extraction space closure, corrections of occlusal contacts, and larger antero-posterior and vertical discrepancies. The use of additional attachments might be more effective for various types of movement, such as bodily expansion of the maxillary posterior teeth, canine and premolar rotational movements, incisors torque control and extrusion of maxillary incisors. Overcorrections might also improve the effectiveness of orthodontic movement. However, overcorrections are not as simple for all movements and need to be made on a case-by-case basis depending on the goal of treatment.
Studies on effectiveness of clear aligners had methodological heterogeneity as they assessed predictability of different types of tooth movements for different teeth by using different materials like Invisalign, F22 aligner and Nuvola system. Retention and stability studies regarding aligners also remain limited in the literature. Therefore, further well-designed and reported researches are required on this subject.
Special thanks to the department of Orthodontics of the Faculty of the dentistry of the University Hassan II of Casablanca. We would also like to acknowledge the support of Professor Farid Bourzgui for the realization of this work and for sharing and discussing the initial idea of the project.
The authors declare no conflict of interest.
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Crotty Alexander",coverURL:"https://cdn.intechopen.com/books/images_new/5471.jpg",editedByType:"Edited by",editors:[{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",slug:"shymaa-enany",fullName:"Shymaa Enany"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:5,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"54154",doi:"10.5772/67338",title:"Staphylococcus aureus: Overview of Bacteriology, Clinical Diseases, Epidemiology, Antibiotic Resistance and Therapeutic Approach",slug:"staphylococcus-aureus-overview-of-bacteriology-clinical-diseases-epidemiology-antibiotic-resistance-",totalDownloads:7219,totalCrossrefCites:14,totalDimensionsCites:27,abstract:"Staphylococcus aureus is an important human pathogen that causes wide range of infectious conditions both in nosocomial and community settings. The Gram-positive pathogen is armed with battery of virulence factors that facilitate to establish infections in the hosts. The organism is well known for its ability to acquire resistance to various antibiotic classes. The emergence and spread of methicillin-resistant S. aureus (MRSA) strains which are often multi-drug resistant in hospitals and subsequently in community resulted in significant mortality and morbidity. The epidemiology of MRSA has been evolving since its initial outbreak which necessitates a comprehensive medical approach to tackle this pathogen. Vancomycin has been the drug of choice for years but its utility was challenged by the emergence of resistance. In the last 10 years or so, newer anti-MRSA antibiotics were approved for clinical use. However, being notorious for developing antibiotic resistance, there is a continuous need for exploring novel anti-MRSA agents from various sources including plants and evaluation of non-antibiotic approaches.",book:{id:"5471",slug:"frontiers-in-i-staphylococcus-aureus-i-",title:"Frontiers in Staphylococcus aureus",fullTitle:"Frontiers in Staphylococcus aureus"},signatures:"Arumugam Gnanamani, Periasamy Hariharan and Maneesh Paul-\nSatyaseela",authors:[{id:"192829",title:"Dr.",name:"Arumugam",middleName:null,surname:"Gnanamani",slug:"arumugam-gnanamani",fullName:"Arumugam Gnanamani"},{id:"204388",title:"Dr.",name:"Periasamy",middleName:null,surname:"Hariharan",slug:"periasamy-hariharan",fullName:"Periasamy Hariharan"},{id:"204389",title:"Dr.",name:"Maneesh",middleName:null,surname:"Paul-Satyaseela",slug:"maneesh-paul-satyaseela",fullName:"Maneesh Paul-Satyaseela"}]},{id:"53782",doi:"10.5772/66645",title:"Methicillin-Resistant Staphylococcus aureus (MRSA) in Food- Producing and Companion Animals and Food Products",slug:"methicillin-resistant-staphylococcus-aureus-mrsa-in-food-producing-and-companion-animals-and-food-pr",totalDownloads:2766,totalCrossrefCites:8,totalDimensionsCites:16,abstract:"Methicillin-resistant Staphylococcus aureus (MRSA) has become a growing concern in companion and food-producing animals. The presence of multidrug-resistance with a wide range of extracellular enterotoxin genes, virulence factors, and Panton-Valentine leukocidin (pvl) cytotoxin genes confer life-threatening traits on MRSA and makes them highly pathogenic and difficult to treat. Clonal complex 398 (CC398), a predominant clonal lineage of livestock-associated-MRSA in domestic animals and retail meat, is capable of infecting humans. In order to monitor and prevent MRSA contamination, it is critical to understand its source and transmission dynamics. In this review, we describe MRSA in food-producing animals (pig, cattle, chicken), horses, pet animals (dogs, cats), and food products (pork, beef, chicken, milk, and fish).",book:{id:"5471",slug:"frontiers-in-i-staphylococcus-aureus-i-",title:"Frontiers in Staphylococcus aureus",fullTitle:"Frontiers in Staphylococcus aureus"},signatures:"Jungwhan Chon, Kidon Sung and Saeed Khan",authors:[{id:"189634",title:"Dr.",name:"Kidon",middleName:null,surname:"Sung",slug:"kidon-sung",fullName:"Kidon Sung"},{id:"190400",title:"Dr.",name:"Jungwhan",middleName:null,surname:"Chon",slug:"jungwhan-chon",fullName:"Jungwhan Chon"},{id:"190401",title:"Dr.",name:"Saeed",middleName:null,surname:"Khan",slug:"saeed-khan",fullName:"Saeed Khan"}]},{id:"52755",doi:"10.5772/65978",title:"Bee Products and Essential Oils as Alternative Agents for Treatment of Infections Caused by S. aureus",slug:"bee-products-and-essential-oils-as-alternative-agents-for-treatment-of-infections-caused-by-s-aureus",totalDownloads:1927,totalCrossrefCites:4,totalDimensionsCites:8,abstract:"Bacteria of the genus Staphylococcus are important human and veterinary pathogens. A crucial characteristic for this group of bacteria is that they can easily acquire mechanisms of antibiotic resistance for a plethora of antibiotics currently in use for human and animal therapies. Therefore, there is a great need to find novel, non-antibiotic chemotherapeutics with marked antistaphylococcal activity. Promising but still underestimated group of potential antistaphylococcal chemotherapeutics constitute bee products: honey, pollen, royal jelly, fermented pollen and especially propolis. Another group of natural products that exhibit promising antibacterial activity is essential oils. Usefulness of bee products and essential oils in the treatment of infections caused by S. aureus has been confirmed by results of many investigations carried out by researches in different regions of the world. In this chapter, we have presented the review of publication in this area as well as perspectives and limitations of future applications of these two groups of natural products.",book:{id:"5471",slug:"frontiers-in-i-staphylococcus-aureus-i-",title:"Frontiers in Staphylococcus aureus",fullTitle:"Frontiers in Staphylococcus aureus"},signatures:"Piotr Szweda and Barbara Kot",authors:[{id:"117528",title:"Dr.",name:"Szweda",middleName:null,surname:"Piotr",slug:"szweda-piotr",fullName:"Szweda Piotr"},{id:"189685",title:"Associate Prof.",name:"Barbara",middleName:null,surname:"Kot",slug:"barbara-kot",fullName:"Barbara Kot"},{id:"195004",title:"Dr.",name:"Barbara",middleName:null,surname:"Kot",slug:"barbara-kot",fullName:"Barbara Kot"}]},{id:"52875",doi:"10.5772/65761",title:"Bacteriophage Therapy: An Alternative for the Treatment of Staphylococcus aureus Infections in Animals and Animal Models",slug:"bacteriophage-therapy-an-alternative-for-the-treatment-of-staphylococcus-aureus-infections-in-animal",totalDownloads:1999,totalCrossrefCites:4,totalDimensionsCites:7,abstract:"Staphylococcus aureus causes hospital-acquired (HA), community-acquired (CA) and companion animal and livestock-associated (LA) infections. Molecular epidemiology studies suggest that although host specificity may be associated with specific genetic lineages, recent human-to-animal and animal-to-human transmissions related to mobile genetic elements have been described. Gene transfers include virulence and antibiotic resistance genes, thus making it difficult to control multidrug resistance S. aureus infections. Bacteriophages (phages) and endolysins, the enzymes responsible for bacterial lysis by phages, are alternatives to the use of antibiotics for the control of S. aureus infections. In this work, we review current advances in the development of phage therapy and the study and design of recombinant endolysins to treat S. aureus infections. Preliminary results of bacteriophage isolation based on molecular epidemiology knowledge show that bacteriophages are specific of genetic lineages and that this strategy may be used as an approach to isolate and evaluate new bacteriophages for therapy.",book:{id:"5471",slug:"frontiers-in-i-staphylococcus-aureus-i-",title:"Frontiers in Staphylococcus aureus",fullTitle:"Frontiers in Staphylococcus aureus"},signatures:"Claudia I. Barrera-Rivas, Norma A. Valle-Hurtado, Graciela M.\nGonzález-Lugo, Víctor M. Baizabal-Aguirre, Alejandro Bravo-Patiño,\nMarcos Cajero-Juárez and Juan J. Valdez-Alarcón",authors:[{id:"191123",title:"Dr.",name:"Juan José",middleName:null,surname:"Valdez-Alarcón",slug:"juan-jose-valdez-alarcon",fullName:"Juan José Valdez-Alarcón"},{id:"195005",title:"Mrs.",name:"Claudia Ibeth",middleName:null,surname:"Barrera-Rivas",slug:"claudia-ibeth-barrera-rivas",fullName:"Claudia Ibeth Barrera-Rivas"},{id:"195006",title:"MSc.",name:"Norma Anahí",middleName:null,surname:"Valle-Hurtado",slug:"norma-anahi-valle-hurtado",fullName:"Norma Anahí Valle-Hurtado"},{id:"195007",title:"MSc.",name:"Graciela M.",middleName:null,surname:"González-Lugo",slug:"graciela-m.-gonzalez-lugo",fullName:"Graciela M. González-Lugo"},{id:"195008",title:"Dr.",name:"Víctor Manuel",middleName:null,surname:"Baizabal-Aguirre",slug:"victor-manuel-baizabal-aguirre",fullName:"Víctor Manuel Baizabal-Aguirre"},{id:"195009",title:"Dr.",name:"Alejandro",middleName:null,surname:"Bravo-Patiño",slug:"alejandro-bravo-patino",fullName:"Alejandro Bravo-Patiño"},{id:"195010",title:"Dr.",name:"Marcos",middleName:null,surname:"Cajero-Juárez",slug:"marcos-cajero-juarez",fullName:"Marcos Cajero-Juárez"}]},{id:"53377",doi:"10.5772/66225",title:"Staphylococcus aureus Bacteremia in Adults",slug:"staphylococcus-aureus-bacteremia-in-adults",totalDownloads:2115,totalCrossrefCites:3,totalDimensionsCites:5,abstract:"Staphylococcus aureus is an important cause of bacteremia, and S. aureus bacteremia constitutes a serious condition with high morbidity and mortality, secondary to multiple complications including infective endocarditis and embolization. The incidence of bacteremia with S. aureus is increasing with more frequent use of medications that lower immune system response, and with the utilization of more invasive medical procedures. In addition, the emergence of resistant S. aureus isolates is becoming more common and can negatively affect the outcome of an individual if not diagnosed and managed properly. Health care workers encounter S. aureus bloodstream infections on a routine basis, and in certain situations, it becomes a very challenging infection to control. Because of the impact this entity has on health care costs and the increased use of resources, it is necessary to highlight the causes, clinical presentation, associated complications, and treatment measures. In this chapter, we will cover each of these points, with somewhat more emphasis on methicillin‐resistant S. aureus that is prevalent in both community and hospital settings and is more commonly associated with worsening prognosis and higher mortality.",book:{id:"5471",slug:"frontiers-in-i-staphylococcus-aureus-i-",title:"Frontiers in Staphylococcus aureus",fullTitle:"Frontiers in Staphylococcus aureus"},signatures:"Dima Youssef and Kate Molony",authors:[{id:"190397",title:"Dr.",name:"Dima",middleName:null,surname:"Youssef",slug:"dima-youssef",fullName:"Dima Youssef"},{id:"195814",title:"Dr.",name:"Kate",middleName:null,surname:"Molony",slug:"kate-molony",fullName:"Kate Molony"}]}],mostDownloadedChaptersLast30Days:[{id:"54154",title:"Staphylococcus aureus: Overview of Bacteriology, Clinical Diseases, Epidemiology, Antibiotic Resistance and Therapeutic Approach",slug:"staphylococcus-aureus-overview-of-bacteriology-clinical-diseases-epidemiology-antibiotic-resistance-",totalDownloads:7218,totalCrossrefCites:14,totalDimensionsCites:27,abstract:"Staphylococcus aureus is an important human pathogen that causes wide range of infectious conditions both in nosocomial and community settings. The Gram-positive pathogen is armed with battery of virulence factors that facilitate to establish infections in the hosts. The organism is well known for its ability to acquire resistance to various antibiotic classes. The emergence and spread of methicillin-resistant S. aureus (MRSA) strains which are often multi-drug resistant in hospitals and subsequently in community resulted in significant mortality and morbidity. The epidemiology of MRSA has been evolving since its initial outbreak which necessitates a comprehensive medical approach to tackle this pathogen. Vancomycin has been the drug of choice for years but its utility was challenged by the emergence of resistance. In the last 10 years or so, newer anti-MRSA antibiotics were approved for clinical use. However, being notorious for developing antibiotic resistance, there is a continuous need for exploring novel anti-MRSA agents from various sources including plants and evaluation of non-antibiotic approaches.",book:{id:"5471",slug:"frontiers-in-i-staphylococcus-aureus-i-",title:"Frontiers in Staphylococcus aureus",fullTitle:"Frontiers in Staphylococcus aureus"},signatures:"Arumugam Gnanamani, Periasamy Hariharan and Maneesh Paul-\nSatyaseela",authors:[{id:"192829",title:"Dr.",name:"Arumugam",middleName:null,surname:"Gnanamani",slug:"arumugam-gnanamani",fullName:"Arumugam Gnanamani"},{id:"204388",title:"Dr.",name:"Periasamy",middleName:null,surname:"Hariharan",slug:"periasamy-hariharan",fullName:"Periasamy Hariharan"},{id:"204389",title:"Dr.",name:"Maneesh",middleName:null,surname:"Paul-Satyaseela",slug:"maneesh-paul-satyaseela",fullName:"Maneesh Paul-Satyaseela"}]},{id:"53377",title:"Staphylococcus aureus Bacteremia in Adults",slug:"staphylococcus-aureus-bacteremia-in-adults",totalDownloads:2115,totalCrossrefCites:3,totalDimensionsCites:5,abstract:"Staphylococcus aureus is an important cause of bacteremia, and S. aureus bacteremia constitutes a serious condition with high morbidity and mortality, secondary to multiple complications including infective endocarditis and embolization. The incidence of bacteremia with S. aureus is increasing with more frequent use of medications that lower immune system response, and with the utilization of more invasive medical procedures. In addition, the emergence of resistant S. aureus isolates is becoming more common and can negatively affect the outcome of an individual if not diagnosed and managed properly. Health care workers encounter S. aureus bloodstream infections on a routine basis, and in certain situations, it becomes a very challenging infection to control. Because of the impact this entity has on health care costs and the increased use of resources, it is necessary to highlight the causes, clinical presentation, associated complications, and treatment measures. In this chapter, we will cover each of these points, with somewhat more emphasis on methicillin‐resistant S. aureus that is prevalent in both community and hospital settings and is more commonly associated with worsening prognosis and higher mortality.",book:{id:"5471",slug:"frontiers-in-i-staphylococcus-aureus-i-",title:"Frontiers in Staphylococcus aureus",fullTitle:"Frontiers in Staphylococcus aureus"},signatures:"Dima Youssef and Kate Molony",authors:[{id:"190397",title:"Dr.",name:"Dima",middleName:null,surname:"Youssef",slug:"dima-youssef",fullName:"Dima Youssef"},{id:"195814",title:"Dr.",name:"Kate",middleName:null,surname:"Molony",slug:"kate-molony",fullName:"Kate Molony"}]},{id:"55253",title:"Clostridium difficile Infection Diagnosis by Biological Molecular Methods",slug:"clostridium-difficile-infection-diagnosis-by-biological-molecular-methods",totalDownloads:2001,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"In the past 15 years, the incidence of Clostridium difficile infection has emerged especially because of the new highly virulent strains. The classical diagnosis methods used to diagnose C. difficile infection take time and the enzyme immunoassay (EIA) test has demonstrated the lack of sensitivity. Even though new modern molecular methods have become available, the diagnosis of C. difficile in patients or healthy carriers remains a big challenge for both clinicians and laboratory staff. In the present chapter, we will list the main genotyping methods, stressing their advantages and disadvantages, as well. A brief presentation of the most useful kit (principle, sensitivity, specificity, benefits and disadvantages) to assess the impact of molecular methods in comparison with classical methods will offer support for future research in the present context of an increasing prevalence of C. difficile infection that represents worldwide, a real public health problem. To improve the patients’ quality of life, to limit hospital transmission, and to save money, we have tried to identify the best diagnosis algorithm as tool in C. difficile diagnosis and surveillance. This algorithm may differ depending on the capacities of the laboratories and on the socioeconomic level of the countries in question.",book:{id:"5831",slug:"clostridium-difficile-a-comprehensive-overview",title:"Clostridium Difficile",fullTitle:"Clostridium Difficile - A Comprehensive Overview"},signatures:"Luminiţa Smaranda Iancu, Andrei Florin Cârlan and Ramona\nGabriela Ursu",authors:[{id:"197809",title:"Prof.",name:"Luminiţa Smaranda",middleName:null,surname:"Iancu",slug:"luminita-smaranda-iancu",fullName:"Luminiţa Smaranda Iancu"},{id:"205531",title:"Dr.",name:"Andrei",middleName:null,surname:"Cârlan",slug:"andrei-carlan",fullName:"Andrei Cârlan"},{id:"205532",title:"Dr.",name:"Ramona Gabriela",middleName:null,surname:"Ursu",slug:"ramona-gabriela-ursu",fullName:"Ramona Gabriela Ursu"}]},{id:"53782",title:"Methicillin-Resistant Staphylococcus aureus (MRSA) in Food- Producing and Companion Animals and Food Products",slug:"methicillin-resistant-staphylococcus-aureus-mrsa-in-food-producing-and-companion-animals-and-food-pr",totalDownloads:2765,totalCrossrefCites:8,totalDimensionsCites:16,abstract:"Methicillin-resistant Staphylococcus aureus (MRSA) has become a growing concern in companion and food-producing animals. The presence of multidrug-resistance with a wide range of extracellular enterotoxin genes, virulence factors, and Panton-Valentine leukocidin (pvl) cytotoxin genes confer life-threatening traits on MRSA and makes them highly pathogenic and difficult to treat. Clonal complex 398 (CC398), a predominant clonal lineage of livestock-associated-MRSA in domestic animals and retail meat, is capable of infecting humans. In order to monitor and prevent MRSA contamination, it is critical to understand its source and transmission dynamics. In this review, we describe MRSA in food-producing animals (pig, cattle, chicken), horses, pet animals (dogs, cats), and food products (pork, beef, chicken, milk, and fish).",book:{id:"5471",slug:"frontiers-in-i-staphylococcus-aureus-i-",title:"Frontiers in Staphylococcus aureus",fullTitle:"Frontiers in Staphylococcus aureus"},signatures:"Jungwhan Chon, Kidon Sung and Saeed Khan",authors:[{id:"189634",title:"Dr.",name:"Kidon",middleName:null,surname:"Sung",slug:"kidon-sung",fullName:"Kidon Sung"},{id:"190400",title:"Dr.",name:"Jungwhan",middleName:null,surname:"Chon",slug:"jungwhan-chon",fullName:"Jungwhan Chon"},{id:"190401",title:"Dr.",name:"Saeed",middleName:null,surname:"Khan",slug:"saeed-khan",fullName:"Saeed Khan"}]},{id:"55751",title:"Overview of Clostridium difficile Infection: Life Cycle, Epidemiology, Antimicrobial Resistance and Treatment",slug:"overview-of-clostridium-difficile-infection-life-cycle-epidemiology-antimicrobial-resistance-and-tre",totalDownloads:2759,totalCrossrefCites:3,totalDimensionsCites:4,abstract:"The use of antimicrobial agents and acquired resistances explains in part the emergence and spreading of epidemic strains of Clostridium difficile. Continued use of antimicrobial therapy still represents an acute danger in triggering the emergence and spreading of new resistant and multiresistant strains including against first-line antibiotics. We examine the pathway of peptidoglycan synthesis in this organism and associated resistances, as well as resistance to other classes of antibiotics. The life cycle of C. difficile involves growth, spore formation and germination. Spores endow the organism with a formidable capacity of persistence in the environment and in the host, resistance, dissemination and infectious potential. Highly resistant spores produced by antibiotic-resistant/multiresistant strains may be one of the most serious challenges we face in what concerns the containment of C. difficile. Finally, we review recent developments in the treatment and prevention of C. difficile infection.",book:{id:"5831",slug:"clostridium-difficile-a-comprehensive-overview",title:"Clostridium Difficile",fullTitle:"Clostridium Difficile - A Comprehensive Overview"},signatures:"Joana Isidro, Aristides L. 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Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null}]}},subseries:{item:{id:"17",type:"subseries",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11413,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). 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