\r\n\tThe protection of biodiversity is a major target of the European Union Marine Strategy Framework Directive, requiring an assessment of the status of biodiversity on the level of species, habitats, and ecosystems including genetic diversity and the role of biodiversity in food web structure and functioning. The restoration of marine ecosystems can support the productivity and reliability of goods and services that the ocean provides to humankind, to maintain ecosystem integrity and stability. Some of the goods produced by the marine ecosystem services are fish harvests, wild plant and animal resources, water, some of the services provided recreation, tourism, breeding and nursery habitats, water transport, carbon sequestration, erosion control, and habitat provision.
",isbn:"978-1-83968-460-9",printIsbn:"978-1-83968-459-3",pdfIsbn:"978-1-83968-544-6",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"727e7eb3d4ba529ec5eb4f150e078523",bookSignature:"Dr. Ana M.M. Marta Gonçalves",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/10845.jpg",keywords:"Non-indigenous Species, Dynamics, Ecosystem Maturation, Ecological Succession, Water Quality, Recovery, Biodiversity, Environmental Status, Ecosystem Services, Goods Production, Carbohydrates, Carrageenan",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 14th 2022",dateEndSecondStepPublish:"June 22nd 2022",dateEndThirdStepPublish:"August 21st 2022",dateEndFourthStepPublish:"November 9th 2022",dateEndFifthStepPublish:"January 8th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"4 days",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. Ana Marta Gonçalves (h-index 19) holds a Ph.D. in Biology, from the University of Coimbra, Portugal, in collaboration with Ghent University, in 2011. During her research career obtained several grants is highly international competitive calls, including the MARS award for young scientists funded by The Royal Netherlands Institute for Sea Research (NIOZ) and the Foundation for Science and Technology (FCT, Portugal) grants.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"320124",title:"Dr.",name:"Ana M.M.",middleName:"Marta",surname:"Gonçalves",slug:"ana-m.m.-goncalves",fullName:"Ana M.M. Gonçalves",profilePictureURL:"https://mts.intechopen.com/storage/users/320124/images/system/320124.jpg",biography:"Ana Marta Gonçalves obtained a Ph.D. in Biology with a specialization in Ecology from the University of Coimbra, Portugal, in collaboration with Ghent University, Belgium, in 2011. Currently, she is an auxiliary researcher at the Marine and Environmental Sciences Center (MARE), Portugal, where she is also a member of the Directive Board. Since 2016, she has been a member of the Scientific Council of the Institute for Interdisciplinary Research, University of Coimbra (IIIUC). Dr. Gonçalves holds various administrative and management positions in international networks, societies (e.g., Society of Environmental Toxicology and Chemistry, AIL), and associations (e.g., PROAQUA). She is an editorial board member and reviewer for several indexed journals. She has published more than 70 journal articles, 50 book chapters, and 165 communications in international scientific events. She participated as a member and/or coordinator in more than twenty-five national and international projects and is currently the coordinator of four research projects. She has supervised more than ninety-five national and international undergraduate and graduate students. She has experience as a teacher of university courses and in accredited training sessions for teachers. Additionally, she has coordinated several ocean literacy and environmental education activities for kindergarten and school students. During her research career, Dr. Gonçalves obtained several grants and a MARS award for young scientists funded by The Royal Netherlands Institute for Sea Research (NIOZ).\n\nShe has expertise in biosafety, biochemical pathways, and impacts of stressors in aquatic species. Her research focus is on the valorization of marine resources and their applications in the industrial sector, such as the food and pharmaceutical industries. 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This goes in parallel with the growth in communication networks and their devices and their increasing capabilities. At the same time, these devices and networks are subject to a great variety of attacks involving manipulation and destruction of data and theft of sensitive information. For storing and accessing data securely, current technology provides several methods of guaranteeing privacy such as data encryption and usage of tamper-resistant hardwares. However, the critical problem arises when there is a requirement for computing (publicly) with private data or to modify functions or algorithms in such a way that they are still executable while their privacy is ensured. This is where homomorphic cryptosystems can be used since these systems enable computations with encrypted data.
In 1978 Rivest et al. (Rivest et al, 1978a) first investigated the design of a homomorphic encryption scheme. Unfortunately, their
The chapter is organized as follows. In Section 2, we provide some basic and fundamental information on cryptography and various types of encryption schemes. Section 3 presents a formal discussion on homomorphic encryption schemes and discusses their various features. In Section 4, we discuss some of the most well-known and classical homomorphic encryption schemes in the literature. Section 5 provides a brief presentation on various properties and applications of homomorphic cryptosystems. Section 6 presents a discussion on fully homomorphic encryption schemes which are the most powerful encryption schemes for providing a framework for computing over encrypted data. Finally, Section 7 concludes the chapter while outlining a number of research directions and emerging trends in this exciting field of computation which has a tremendous potential of finding applications in the real-world deployments.
In this Section, we will recall some important concepts on encryption schemes. For more detailed information, the reader may refer to (Menezes et al., 1997; Van Tilborg, 2011). Encryption schemes are designed to preserve confidentiality. The security of encryption schemes must not rely on the obfuscation of their codes, but it should only be based on the secrecy of the key used in the encryption process. Encryption schemes are broadly of two types:
Usually, to evaluate the attack capacity of an adversary, we distinguish among several contexts (Diffie & Hellman, 1976):
A particular plaintext may be encrypted in a too much structured way. With RSA, messages 0 and 1 are always encrypted as 0 and 1, respectively.
It may be easy to compute some partial information about the plaintext: with RSA, the ciphertext
When using a deterministic encryption scheme, it is easy to detect when the same message is sent twice while being processed with the same key.
In view of the problems stated above, we prefer encryption schemes to be probabilistic. In case of symmetric schemes, we introduce a random vector in the encryption process (e.g., in the pseudo-random generator for stream ciphers, or in the operating mode for block ciphers) – generally called
A simple consequence of this requirement of the encryption schemes to be preferably probabilistic appears in the phenomenon called
During the last few years, homomorphic encryption schemes have been studied extensively since they have become more and more important in many different cryptographic protocols such as, e.g., voting protocols. In this Section, we introduce homomorphic cryptosystems in three steps:
Informally speaking, a homomorphic cryptosystem is a cryptosystem with the additional property that there exists an efficient algorithm to compute an encryption of the sum or the product, of two messages given the public key and the encryptions of the messages but not the messages themselves.
If
With respect to the aforementioned definitions, the following points are worth noticing:
For a homomorphic encryption scheme to be efficient, it is crucial to make sure that the size of the ciphertexts remains polynomially bounded in the security parameter σ during repeated computations.
The security aspects, definitions, and models of homomorphic cryptosystems are the same as those for other cryptosystems.
If the encryption algorithm
where
Usually in the RSA scheme as well as in most of the cryptosystems which are based on the difficulty of factoring the security parameter σ is the bit length of
Since this scheme is probabilistic, the encryption algorithm gets as additional input a random value
The algorithms
In the above equation,
A public-key homomorphic encryption scheme on a (semi-)ring (
Thus in a scalar homomorphic scheme, it is possible to compute an encryption
We will denote by
For instance, in a probabilistic, homomorphic cryptosystem on (
If
Some researchers also tried to find candidates for algebraically homomorphic schemes. In 1993, Fellows and Koblitz presented an algebraic public-key cryptosystem called Polly Cracker (Fellows & Koblitz, 1993). It is algebraically homomorphic and provably secure. Unfortunately, the scheme has a number of difficulties and is not efficient concerning the ciphertext length. Firstly, Polly Cracker is a polynomial-based system. Therefore, computing an encryption of the product
In 2002, J. Domingo-Ferrer developed a probabilistic, algebraically homomorphic secret-key cryptosystem (Domingo-Ferrer, 2002). However, this scheme was not efficient since there was an exponential blowup in the ciphertext length during repeated multiplications that were required to be performed. Moreover, it was also broken by Wagner and Bao (Bao, 2003; Wagner, 2003).
Thus considering homomorphic encryption schemes on groups instead of rings seems more promising to design a possible algebraically homomorphic encryption scheme. It brings us closer to structures that have been successfully used in cryptography. The following theorem shows that indeed the search for algebraically homomorphic schemes can be reduced to the search for homomorphic schemes on special non-abelian groups (Rappe, 2004).
Homomorphic encryption schemes on groups have been extensively studied. For instance, we have homomorphic schemes on groups
Grigoriev and Ponomarenko propose a novel definition of homomorphic cryptosystems on which they base a method to construct homomorphic cryptosystems over arbitrary finite groups including non-abelian groups (Grigoriev & Ponomarenko, 2006). Their construction method is based on the fact that every finite group is an epimorphic image of a free product of finite cyclic groups. It uses existing homomorphic encryption schemes on finite cyclic groups as building blocks to obtain homomorphic encryption schemes on arbitrary finite groups. Since the ciphertext space obtained from the encryption scheme is a free product of groups, an exponential blowup of the ciphertext lengths during repeated computations is produced as a result. The reason is that the length of the product of two elements
Grigoriev and Ponomarenko propose another method to encrypt arbitrary finite groups homomorphically (Grigoriev & Ponomarenko, 2004). This method is based on the difficulty of the membership problem for groups of integer matrices, while in (Grigoriev & Ponomarenko, 2006) it is based on the difficulty of factoring. However, as before, this scheme is not efficient. Moreover, in (Grigoriev & Ponomarenko, 2004), an algebraically homomorphic cryptosystem over finite commutative rings is proposed. However, owing to its immense size, it is infeasible to implement in real-world applications.
In this Section, we describe some classical homomorphic encryption systems which have created substantial interest among the researchers in the domain of cryptography. We start with the first probabilistic systems proposed by Goldwasser and Micali in 1982 (Goldwasser & Micali, 1982; Goldwasser & Micali, 1984) and then discuss the famous Paillier’s encryption scheme (Paillier, 1999) and its improvements. Paillier’s scheme and its variants are well-known for their efficiency and the high level of security that they provide for homomorphic encryption. We do not discuss their mathematical considerations in detail, but summarize their important parameters and properties.
Goldwasser-Micali (GM) scheme can be viewed from another perspective. When looked from this angle, the basic principle of this scheme is to partition a well-chosen subset of integers modulo
An inherent drawback of homomorphic cryptosystems is that attacks on these systems might possibly exploit their additional structural information. For instance, using plain RSA (Rivest et al., 1978b) for signing, the multiplication of two signatures yields a valid signature of the product of the two corresponding messages. Although there are many ways to avoid such attacks, for instance, by application of hash functions, the use of redundancy or probabilistic schemes, this potential weakness leads us to the question why homomorphic schemes should be used instead of conventional cryptosystems under certain situations. The main reason for the interest in homomorphic cryptosystems is its wide application scope. There are theoretical as well as practical applications in different areas of cryptography. In the following, we list some of the main applications and properties of homomorphic schemes and summarize the idea behind them.
Homomorphic encryption schemes have some interesting mathematical properties. In the following, we mention some of these properties.
It obvious that every probabilistic homomorphic cryptosystem is re-randomizable. Without loss of generality, we assume that the cryptosystem is additively homomorphic. Given
where
In 2009, Gentry described the first plausible construction of a fully homomorphic cryptosystem that supports both addition and multiplication (Gentry, 2009). Gentry’s proposed fully homomorphic encryption consists of several steps: First, it constructs a
For designing a bootstrappable scheme, Gentry presented a somewhat homomorphic scheme (Gentry, 2009) which is roughly a GGH (Goldreich, Goldwasser, Halevi)-type scheme (Goldreich et al., 1997; Micciancio, 2001) over ideal lattices. Gentry later proved that with an appropriate key-generation procedure, the security of that scheme can be reduced to the worst-case hardness of some lattice problems in ideal lattice constructions (Gentry, 2010). Since this somewhat homomorphic scheme is not bootstrappable, Gentry described a transformation to squash the decryption procedure, reducing the degree of the decryption polynomial (Gentry, 2009). This is done by adding to the public key, an additional hint about the secret key in the form of a
Gentry’s construction is quite involved – the secret key, even in the private key version of his scheme is a short basis of a
A parallel line of work that utilizes ideal lattices in cryptography dates back to the NTRU cryptosystem (Hoffstein et al., 1998). This approach uses ideal lattices for efficient cryptographic constructions. The additional structure of ideal lattices, compared to ordinary lattices, makes their representation more powerful and enables faster computation. Motivated by the work of Micciancio (Micciancio, 2007), a significant number of work (Peikert & Rosen, 2006; Lyubashevsky & Micciancio, 2006; Peikert & Rosen, 2007; Lyubashevsky et al., 2008; Lybashevsky & Micciancio, 2008) has produced efficient constructions of various cryptographic primitives whose security can formally be reduced to the hardness of short-vector problems in ideal lattices (Brakerski & Vaikuntanathan, 2011).
Lyubashevsky et al. (Lyubashevsky et al., 2010) present the
Brakerski and Vaikuntanathan raised a natural question that whether the above approaches (i.e., ideal lattices and RLWE) can be effectively exploited so that benefits of both these approaches can be achieved at the same time – namely the functional powerfulness on the one hand (i.e., the ideal lattice approach) and the simplicity and efficiency of the other (i.e., RLWE). They have shown that indeed this can be done (Brakerski & Vaikuntanathan, 2011). They have constructed a somewhat homomorphic encryption scheme based on RLWE. The scheme inherits the simplicity and efficiency, as well as the worst case relation to ideal lattices. Moreover, the scheme enjoys
Smart and Vercauteren (Smart & Vercauteren, 2010) present a fully homomorphic encryption scheme that has smaller key and ciphertext sizes. The construction proposed by the authors follows the fully homomorphic construction based on ideal lattices proposed by Gentry (Gentry, 2009). It produces a fully homomorphic scheme from a
Gentry and Halevi presented a novel implementation approach for the variant of Smart and Vercauteren proposition (Smart & Vercauteren, 2010), which had a greatly improved key generation phase (Gentry & Halevi, 2011). In particular, the authors have noted that the key generation (for cyclotomic fields) is essentially an application of a
Researchers have also examined ways of improving key generation in fully homomorphic encryption schemes. For example, in (Ogura et al., 2010), a method is proposed for construction of keys for essentially random number fields by pulling random elements and analyzing
Stehle and Steinfield improved Gentry’s fully homomorphic scheme and obtained a faster fully homomorphic scheme with
In (Chunsheng, 2012), Chunsheng proposed a modification of the fully homomorphic encryption scheme of Smart and Vercauteren (Smart & Vercauteren, 2010). The author has applied a
Boneh and Freeman propose a linearly homomorphic signature scheme that authenticates vector subspaces of a given ambient space (Boneh & Freeman, 2011). The scheme has several novel features that were not present in any of the existing similar schemes. First, the scheme is the first of its kind that enables
The study of fully homomorphic encryption has led to a number of new and exciting concepts and questions, as well as a powerful tool-kit to address them. We conclude the chapter by discussing a number of research directions related to the domain of fully homomorphic encryption and more generally, on the problem of computing on encrypted data.
Answering this question turns out to be tricky. Boneh, Segev and Waters (Boneh et al., 2011) propose the notion of
It is also interesting to extend the definition of non-malleability to allow for
In addition to the scenarios where it is beneficial to keep all data encrypted and to perform computations on encrypted data, fully homomorphic encryption can be gainfully exploited to solve a number of practical problems in cryptography. Two such examples are the problems of
The Italian National Health Service, characterized by the principles of universality, equality and equity, has suffered over the years an erosion of the aforementioned pillars also due to the systematic decreases in funding. In addition, the balance of the entire social welfare system is today subjected to an unexpected and very significant attack caused by the health emergency dictated by COVID-19.
The Italian model, created by Law n. 833/1978, was invoked evidently to the British experience of the original N.H.S. [1], while being distinguished by an accentuation of the intervention public. Wanting to summarize the criteria of the law establishing the NHS, 5 key points can be identified: a) “universality” of the provision of assistance services, b) “uniqueness” of the management of health facilities and hospitals by the USL (Local Health Units), the real engine of the reform; c) “equality” in carrying out therapeutic treatments; d) planning of assistance objectives and resources financial.
The 1978 reform implemented the constitutional provision of art. 32 of the Constitution, preparing a health network suitable for an organic and global protection of health. Just the art. 1 of the aforementioned law openly recalls the constitutional text, defining the protection of health «as fundamental right of the individual and collective interest» (art. 1, paragraph 1) and in paragraph 2, following the provisions of art. 32 of the Italian Constitution: «the protection of physical and mental health must take place in respect for the dignity and freedom of the human person». Strictly consequential with respect to this regulatory provision, it is the direct intervention of the public authorities in the organization and in the provision of assistance itself.
In this regard, it is necessary to highlight that the definition of health protection does not only concern the absence of disease or disability. These references are now reductive and simplistic, so much so that the Organization World Health Organization has stated that health must be done to mean “a state of complete physical, mental and social well-being […] Condition of harmonic functional and physical balance and psychic organism dynamically integrated into its environment natural and social” [2]. Thus, the notion of health cannot yet be linked to the absence of infirmity, but has undergone a significant expansion of both a biological and social nature, alongside integrity physics of a static nature, also a dynamic element e relational [3].
In the light of the constitutional and normative arguments already mentioned, the solidity of the founding principles of the nal Health Service outlined since 1978 is of primary importance. Subsequently - already represent a substantial modification of the original structure on which the epidemic from Covid-19 had a decisive impact.
With reference to financial resources, it should be noted that the crisis of 2007–2008 had already triggered a spiral of decrease in economic allocations also through the provision of cost containment measures (for example: increase in the sharing of the so-called ticket and blocking of turnover).
The aforementioned measures have achieved, in the short term, the objectives set, so much so that in 2012 there was a beginning of a decrease in public health expenditure. This reflection, however, must be completed with a broader examination. In order to fully understand the overall picture, it is necessary to highlight that healthcare expenditure depends on multiple components: the aging of the population, epidemiological change, scientific progress and the change in information asymmetries between doctor and patient. The variation of each of these factors determines a change in the demand for services and therefore has an impact on the Health Service and its economic needs.
The first element to be evaluated is the demographic one. It is undeniable that there has been an increase in life expectancy. In Italy, from 1960 to today, life expectancy at birth has increased by 12.8 years for women and by 13.6 years for men, so much so that the average age of women is 85.2 years and for men it is 80.8 years. The national average is 83 years compared to the 80 years of the OECD average [4].
These data, together with the slowdown in the birth rate, have produced an increase in the elderly population, to which new welfare needs are linked.
The exponential increase in chronic diseases (for example: cardiovascular diseases, cancer, diabetes and dementia) - those most present in the elderly population - has a significant impact on both the organizational structure of the National Health Service and the economic one. Suffice it to say that in Europe in 2016 the treatment of cardiovascular diseases alone cost 192 billion euros, much higher than the expenditure necessary for the diseases that most afflict the younger population [5].
Another factor that affects the health organization and its financing is that linked to scientific progress and technological innovation. This element does not depend on the choices of each individual country, but on investments in research and development by manufacturing companies (especially pharmaceutical companies). The public resources made available in this field have the effect of conditioning the degree of access to knowledge and new technologies. In summary, the availability of about 14,000 medical device patents each year provides answers to health problems and creates, on the other hand, a new perceived need and, consequently, a new demand for assistance with undeniable repercussions on health care costs.
Think that the growth of technological innovation is much higher than the growth rate of the economy, so much so that between 2008 and 2012 while Italy recorded a decrease in GDP equal to 2.3%, in Europe 1 patent for medical devices was registered every 38 minutes [6], proving the fact that the National Health Service cannot keep up with the technical and scientific developments.
The last element of this picture of factors is represented by the variation of information asymmetries between doctors and patients dictated by the ease of acquiring information through the mass media and, above all, through the internet. If this increases the levels of knowledge of citizens, on the other hand, information bulimia also increases the risk of inappropriate requests, up to the so-called defensive medicine, a prescriptive modality that does not safeguard the patient’s health, but removes the risk of professional liability, increasing inappropriate spending.
All the aforementioned affect the National Health Service and determine an ever-increasing and different demand for services, moreover in an emergency context dictated by the spread of COVID-19, which requires new financial flows and imposes a radical organizational change.
The entire issue of the health organization must also be read in the light of constitutional jurisprudence.
The Italian Constitutional Court, in implementation of art. 32 of the Constitution [7], has ruled that the right to health protection, understood as a request for services and benefits, is “primary and fundamental” and requires “full and comprehensive protection” [8].
This interpretative orientation changed, however, in the 1990s, when the need to contain public spending was imposed [9]. In the last decade of the last millennium, in fact, the Italian public debt had come close to 100% of GDP, while the public deficit was 11%. Especially since 1992 the situation has appeared out of control, so much so that the successive Governments (the first in this sense was the one chaired by Prof. Giuliano Amato) have begun a new phase of fiscal consolidation, with inevitable effects also on health expenditure [10].
The sentence of the Constitutional Court no. 455/1990 with which, while reiterating that the right to obtain health services must be guaranteed to every individual, he stated that this right is conditioned by the legislative choices of balancing the protection of health with other constitutionally protected interests: “taking into account of the objective limits that the legislator himself encounters in his work of implementation in relation to the organizational and financial resources available at the moment” [11]. For the first time it was established that the right to health protection had to deal with economic and organizational possibilities [12].
The subsequent evolution of constitutional jurisprudence has confirmed the need to achieve a balance between the right to benefits and economic and organizational limits, but has also provided for an essential core of the right to the protection of health that can never be undermined [13]: “in the balance of constitutional values operated by the legislator had an absolutely preponderant weight, such as to compress the essential core of the right to health connected to the inviolable dignity of the human person, we would be faced with a macroscopically unreasonable exercise of legislative discretion” [14].
Constitutional jurisprudence relating to the patient’s freedom of choice is also of considerable importance. Precisely the need to take into account the limited economic resources and the need for general health planning led the Italian Constitutional Court to establish that the patient’s freedom of choice of the health facility at which to carry out a diagnostic examination or a medical intervention cannot be considered as an absolute right because of the incompressible economic needs [15].
The above is a confirmation, from the wall of the Italian Constitutional Court, of the policies to contain health costs, albeit within the limits of a reasonable balance with the various constitutionally relevant interests.
Looking at the evolution of public policies in the health field, one must take into account the multiple choices made by the Italian Regions in the organization of Regional Health Services.
In most cases there has been a progressive unification of Local Health Authorities (ASL) and Hospitals (AO). One of the first Regions to make this choice was the Marche Region with the creation in 2003 of the Single Regional Health Authority (ASUR). This example was followed by the Abruzzo Region, with only 4 ASLs, and by Umbria, which passed to 2 ASLs.
Further examples can be given on the choice of reduction. Puglia already after the health reform of 1992 had gone from 55 Local Health Units to 12 ASLs, but in 2007 it decided to carry out another merger until it reached only 6 ASLs.
In 2015, the Tuscany Region reduced the ASLs from 12 to 3, and 4 university companies were added to these. In 2014, the Emilia Romagna Region created a single ASL (for the territories of Forlì, Cesena, Ravenna and Rimini) with over 1 million inhabitants, 12,000 employees and a budget of 2.2 billion euros.
In 2015, on the other hand, the Lombardy Region replaced the ASLs with 8 Health Protection Agencies and 25 Territorial Social and Health Companies.
Analyzing the different choices of the Italian Regions, in an effort of synthesis it can be said that the mergers were designed to create economies of scale, to simplify administrative procedures, to eliminate duplications. It should also be noted that these choices, in the medium term, can also cause inefficiencies linked to the excessive size of the ASLs and difficulties in creating middle management.
The above must be completed with an assessment of the evolution of the hospital organization.
The Law Decree n. 95 of 6 July 2012 provided for a reduction in hospital beds, so much so that a maximum value of 3.7 beds per 1,000 inhabitants was reached, compared to the previous value of 4 beds per 1,000 inhabitants. To this was also added an evaluation of small public hospitals in order to dismiss these structures and favor home care.
The process of reducing the number of beds and reorganizing the network of small hospitals was implemented with the decree of the Ministry of Health no. 70 of 2 April 2015 which defined the qualitative, structural, technological and quantitative standards. This legislative choice was aimed at reducing health care costs, reorganizing the hospital network and moving health care for many chronic diseases outside hospitals to put it at the expense of “territorial assistance”.
In reality, however, this reorganization made the mistake of having accelerated the rationalization of hospitals by the Italian Regions, but it was not as effective as regards the creation of a new territorial assistance which, therefore, remained incomplete in many parts of the national territory.
After the economic crisis of 2008 there was a gradual reduction in the financing of the National Health Service. In the period between 2009 and 2014, Italian public health expenditure increased each year by 0.7%, while from 2003 to 2008 the growth in health expenditure was equal to 6%.
These policies to contain national health expenditure and the choices of the Italian Regions to reduce their budget, have had undeniable positive effects both on the national budget and that of many Regions that were in financial crisis (think of Regions such as Lazio, Campania and Sicily). At the same time, however, these choices have had an impact on health care.
The first effect of the reduction of economic resources for the National Health Service was the reduction of some assistance services. This aspect had a fundamental impact on citizens as those who had the financial availability were able to turn to private health facilities, while those who could not afford this expense independently had to give up temporarily.
This has also led to an increase in patient waiting lists at public health facilities. The “Annual report on hospitalization activities” of the Italian Ministry of Health (2019) contains some significant data. For example, in 2017 the average expectations were over 27 days for breast cancer, 53 days for prostate cancer, 119 days for tonsillectomy, 90 days for inguinal hernia [16].
In Italy 40% of specialist health visits, 49% of rehabilitation services and 23% of diagnostic tests are paid directly by citizens [17].
In addition, the policies to contain health costs also had a direct influence on medical personnel. In Italy there is no shortage of doctors, so much so that every year there are about 9,000 graduates in medicine and surgery, but only 6,000 graduates each year can receive a specialist scholarship. This means that every year in Italy about 2,000 doctors live in the uncertainty of their professional future, despite the enormous need for new doctors by the National Health Service.
To confirm what has been said, the fact that in the Veneto Region there is a deficit of 400 doctors, in the Piedmont Region and in the Puglia Region there is a need for about 300 doctors. If we look up to 2025, a national shortage of about 16,700 medical specialists is expected. An incredible paradox [18].
It must be borne in mind that in recent years there has been a change in the choices of health policies. The resources allocated to the National Health Service have been slowly increased, although still largely insufficient. In the 2019 Economic and Financial Document, health expenditure for 2018 was estimated at approximately 115.4 billion euros, recording a growth of 1.6% compared to 2017.
This precarious balance has, however, been completely upset by the emergency caused by the spread of COVID-19 which has imposed a campaign of staffing and a sudden technological and infrastructural investment of which the exact extent is not yet known. In this regard, it must be taken into account that the first legislative intervention approved in 2020, in full epidemiological emergency, was the “Cura Italia” Law Decree, which immediately provided for the following emergency measures: additional funding for incentives to healthcare personnel (Article 1); hiring by the Minister of Health of 40 medical executives, 18 veterinary executives and 29 non-executive personnel, allocating over 5 million euros for 2020, 6,790,659.00 euros for 2021 and 2022 and almost 1,700 € .000.00 for 2023 (Article 2); possibility for the Regions to purchase medical equipment also from private health facilities (art. 3); an increase in the financing of healthcare for an amount of almost 2 million euros (Article 17).
This was only the first step in a series of economic increases which during 2020 (and also at the beginning of 2021) were expected to address a condition that has upset not only Italian society, but above all the entire National Health Service.
All this must also be taken into account the impact that the national and global financial crisis that was triggered by the pandemic, moreover on the Italian economy, which even before the health emergency had shown signs of weakness [19]. One of the first reports by the Moody’s agency supported a possible recession in the Italian economy with a reduction in GDP of over 10%. For this reason, what must be watched carefully is the behavior of both the European Union and that of the ECB.
The evolutionary framework of the interventions of economic and organizational policies in the health field gives us a plurality of indices from which multiple inequalities emerge, so much so as to touch the foundations of the constitutional right to the protection of health.
The first imbalance is between Northern Italy and Southern Italy. Already today in the Northern Regions the life expectancy for men and women is respectively 81.2 years and 85.6 years, while in the South the life expectancy for men and women is 79.8 and 84.1 years. Years.
An index of inequality is represented by healthcare mobility between Regions, so much so that in 2017 88% of Nitalians who moved to be treated were hospitalized in Lombardy, Emilia Romagna, Veneto, while 77% of citizens who moved to try to be treated came from the Regions of Central and Southern Italy (Puglia, Sicily, Lazio, Calabria and Campania).
A further sign of inequality is linked to the renunciation of care by the poorest sections of the population. 43% of Italians with serious economic difficulties declare that they are not in good health, while only 23% of those who do not have economic difficulties believe that they are not in good health [Italian Higher Institute of Health, “Report on inequalities”, 2019]. It must also be assessed that 55% of people with a low level of education report that they are in poor health (compared to 20% of Italian graduates) and 12% say they have depressive symptoms (compared to 4% of graduates).
This context of inequalities is even more relevant if we consider that over 11 million Italians in 2017 gave up on treatment for economic reasons and 7 million Italians went into debt to take care of themselves.
This fragile health care landscape is also characterized by significant paradoxes, the first of which is linked to the ineffectiveness of care services. It has been estimated that 19% of public spending, 40% of private household spending and 50% of the expenditure incurred by insurance policies, is used for diagnosis or for inappropriate or ineffective health services.
All this represents the photograph of a National Health Service that was already present before the COVID-19 emergency was characterized by gaps and contradictions and that, with absolute probability (if not certain), the spread of the virus will only exacerbate, especially with regard to of the poorest faces of the population, those socially more fragile and, in particular, towards the elderly.
We are in the presence of welfare, territorial and access to care inequalities that risk completely undermining not only the foundations of the National Health Service, but also those of the constitutionally protected right to health protection.
Furthermore, still on the subject of inequalities, the annual reports of the World Bank, the International Monetary Fund and the OECD, which constantly provide data on the increase in the concentration of wealth, cannot fail to have reinterpreted on the welfare state and, consequently, on the gap between the assistance potentials provided by technical-scientific progress and the actual levels of assistance provided.
From the above it follows that the picture of the evolution of Italian healthcare, also in the light of the contingencies that the current health emergency, opens the way to pressing fundamental doubts about the effectiveness of the principles of universality, equality and equity that inspired the creation of our SSN and which today risk being only chimeras.
Faced with this complex picture, it is necessary to think not only about how to convert entire healthcare companies into hospitals dedicated to the care of patients suffering from Covid-19, moving patients with other diseases to other small hospitals, but it is also urgent to already start planning a future in which there are integrated assistance systems, with large hospitals that are centers in which investments are concentrated and specialization is developed, connected in telemedicine with small hospitals.
In this new vision, one cannot imagine addressing the issue of small hospitals only with a view to reducing costs, but it is necessary to plan their use in a perspective of continuity of care and strengthening of territorial assistance.
On the side of medical personnel, the time has now come to face the season of the shortage of doctors and nurses with determination, nor can we think that this problem can be solved exclusively with urgent procedures for the recruitment of usable staff to fight the pandemic. Instead, it is necessary to design new care models and launch real training programs for the phase following Covid-19. The contingent criticality must be transformed into an opportunity to strengthen a poor health system, first of all, from the point of view of the staff. It will be possible to plan the reconversion of services by leveraging the energies and skills of young doctors to be included in the National Health Service.
Furthermore, it would be short-sighted to limit ourselves to asking for economic policies to increase public spending to be allocated to the health service (back to a percentage of about 7% of GDP), nor would it be satisfactory to limit ourselves to hoping for investments for the adaptation of structures. Hospital. Instead, it is necessary, right from the start, to train young doctors and nurses, as well as new professional figures capable of bringing new services.
Finally, any reorganization of the National Health Service would be empty if the problem were not raised (and the solution started) of strengthening local health care, because only through this simple (but essential) Copernican revolution will we be able to address both the needs imposed by the pandemic and the needs that health care has to face every day in order to provide answers to the many health protection questions raised by the population.
The Internet has irrevocably changed the dynamics of scholarly communication and publishing. Consequently, we find it necessary to indicate, unambiguously, our definition of what we consider to be a published scientific work.
",metaTitle:"Prior Publication Policy",metaDescription:"Prior Publication Policy",metaKeywords:null,canonicalURL:"/page/prior-publication-policy",contentRaw:'[{"type":"htmlEditorComponent","content":"A significant number of working papers, early drafts, and similar work in progress are openly shared online between members of the scientific community. It has become common to announce one’s own research on a personal website or a blog to gather comments and suggestions from other researchers. Such works and online postings are, indeed, published in the sense that they are made publicly available. However, this does not mean that if submitted for publication by IntechOpen they are not original works. We differentiate between reviewed and non-reviewed works when determining whether a work is original and has been published in a scholarly sense or not.
\\n\\nThe significance of Peer Review cannot be overstated when it comes to defining, in our terms, what constitutes a published scientific work. Peer Review is widely considered to be the cornerstone of modern publishing processes and the key value-adding contribution to a scholarly manuscript that a publisher can make.
\\n\\nOther than the issue of originality, research misconduct is another major issue that all publishers have to address. IntechOpen’s Retraction & Correction Policy and various publication ethics guidelines identify both redundant publication and (self)plagiarism to fall within the definition of research misconduct, thus constituting grounds for rejection or the issue of a Retraction if the work has already been published.
\\n\\nIn order to facilitate the tracking of a manuscript’s publishing history and its development from its earliest draft to the manuscript submitted, we encourage Authors to disclose any instances of a manuscript’s prior publication, whether it be through a conference presentation, a newspaper article, a working paper publicly available in a repository or a blog post.
\\n\\nA note to the Academic Editor containing detailed information about a submitted manuscript’s previous public availability is the preferred means of reporting prior publication. This helps us determine if there are any earlier versions of a manuscript that should be disclosed to our readers or if any of those earlier versions should be cited and listed in a manuscript’s references.
\\n\\nSome basic information about the editorial treatment of different varieties of prior publication is laid out below:
\\n\\n1. CONFERENCE PAPERS & PRESENTATIONS
\\n\\nGiven that conference papers and presentations generally pass through some sort of peer or editorial review, we consider them to be published in the accepted scholarly sense, particularly if they are published as a part of conference proceedings.
\\n\\nAll submitted manuscripts originating from a previously published conference paper must contain at least 50% of new original content to be accepted for review and considered for publication.
\\n\\nAuthors are required to report any links their manuscript might have with their earlier conference papers and presentations in a note to the Academic Editor, as well as in the manuscript itself. Additionally, Authors should obtain any necessary permissions from the publisher of their conference paper if copyright transfer occurred during the publishing process. Failure to do so may prevent Us from publishing an otherwise worthy work.
\\n\\n2. NEWSPAPER & MAGAZINE ARTICLES
\\n\\nNewspaper and magazine articles usually do not pass through any extensive peer or editorial review and we do not consider them to be published in the scholarly sense. Articles appearing in newspapers and magazines rarely possess the depth and structure characteristic of scholarly articles.
\\n\\nSubmitted manuscripts stemming from a previous newspaper or magazine article will be accepted for review and considered for publication. However, Authors are strongly advised to report any such publication in an accompanying note to the External Editor.
\\n\\nAs with the conference papers and presentations, Authors should obtain any necessary permissions from the newspaper or magazine that published the work, and indicate that they have done so in a note to the External Editor.
\\n\\n3. GREY LITERATURE
\\n\\nWhite papers, working papers, technical reports and all other forms of papers which fall within the scope of the ‘Luxembourg definition’ of grey literature do not pass through any extensive peer or editorial review and we do not consider them to be published in the scholarly sense.
\\n\\nAlthough such papers are regularly made publicly available via personal websites and institutional repositories, their general purpose is to gather comments and feedback from Authors’ colleagues in order to further improve a manuscript intended for future publication.
\\n\\nWhen submitting their work, Authors are required to disclose the existence of any publicly available earlier drafts in a note to the Academic Editor. In cases where earlier drafts of the submitted version of the manuscript are publicly available, any overlap between the versions will generally not be considered an instance of self-plagiarism.
\\n\\n4. SOCIAL MEDIA, BLOG & MESSAGE BOARD POSTINGS
\\n\\nWe feel that social media, blogs and message boards are generally used with the same intention as grey literature, to formulate ideas for a manuscript and gather early feedback from like-minded researchers in order to improve a particular piece of work before submitting it for publication. Therefore, we do not consider such internet postings to be publication in the scholarly sense.
\\n\\nNevertheless, Authors are encouraged to disclose the existence of any internet postings in which they outline and describe their research or posted passages of their manuscripts in a note to the Academic Editor. Please note that we will not strictly enforce this request in the same way that we would instructions we consider to be part of our conditions of acceptance for publication. We understand that it may be difficult to keep track of all one’s internet postings in which the researcher´s current work might be mentioned.
\\n\\nIn cases where there is any overlap between the Author´s submitted manuscript and related internet postings, we will generally not consider it to be an instance of self-plagiarism. This also holds true for any co-Author as well.
\\n\\nFor more information on this policy please contact permissions@intechopen.com.
\\n\\nPolicy last updated: 2017-03-20
\\n"}]'},components:[{type:"htmlEditorComponent",content:'A significant number of working papers, early drafts, and similar work in progress are openly shared online between members of the scientific community. It has become common to announce one’s own research on a personal website or a blog to gather comments and suggestions from other researchers. Such works and online postings are, indeed, published in the sense that they are made publicly available. However, this does not mean that if submitted for publication by IntechOpen they are not original works. We differentiate between reviewed and non-reviewed works when determining whether a work is original and has been published in a scholarly sense or not.
\n\nThe significance of Peer Review cannot be overstated when it comes to defining, in our terms, what constitutes a published scientific work. Peer Review is widely considered to be the cornerstone of modern publishing processes and the key value-adding contribution to a scholarly manuscript that a publisher can make.
\n\nOther than the issue of originality, research misconduct is another major issue that all publishers have to address. IntechOpen’s Retraction & Correction Policy and various publication ethics guidelines identify both redundant publication and (self)plagiarism to fall within the definition of research misconduct, thus constituting grounds for rejection or the issue of a Retraction if the work has already been published.
\n\nIn order to facilitate the tracking of a manuscript’s publishing history and its development from its earliest draft to the manuscript submitted, we encourage Authors to disclose any instances of a manuscript’s prior publication, whether it be through a conference presentation, a newspaper article, a working paper publicly available in a repository or a blog post.
\n\nA note to the Academic Editor containing detailed information about a submitted manuscript’s previous public availability is the preferred means of reporting prior publication. This helps us determine if there are any earlier versions of a manuscript that should be disclosed to our readers or if any of those earlier versions should be cited and listed in a manuscript’s references.
\n\nSome basic information about the editorial treatment of different varieties of prior publication is laid out below:
\n\n1. CONFERENCE PAPERS & PRESENTATIONS
\n\nGiven that conference papers and presentations generally pass through some sort of peer or editorial review, we consider them to be published in the accepted scholarly sense, particularly if they are published as a part of conference proceedings.
\n\nAll submitted manuscripts originating from a previously published conference paper must contain at least 50% of new original content to be accepted for review and considered for publication.
\n\nAuthors are required to report any links their manuscript might have with their earlier conference papers and presentations in a note to the Academic Editor, as well as in the manuscript itself. Additionally, Authors should obtain any necessary permissions from the publisher of their conference paper if copyright transfer occurred during the publishing process. Failure to do so may prevent Us from publishing an otherwise worthy work.
\n\n2. NEWSPAPER & MAGAZINE ARTICLES
\n\nNewspaper and magazine articles usually do not pass through any extensive peer or editorial review and we do not consider them to be published in the scholarly sense. Articles appearing in newspapers and magazines rarely possess the depth and structure characteristic of scholarly articles.
\n\nSubmitted manuscripts stemming from a previous newspaper or magazine article will be accepted for review and considered for publication. However, Authors are strongly advised to report any such publication in an accompanying note to the External Editor.
\n\nAs with the conference papers and presentations, Authors should obtain any necessary permissions from the newspaper or magazine that published the work, and indicate that they have done so in a note to the External Editor.
\n\n3. GREY LITERATURE
\n\nWhite papers, working papers, technical reports and all other forms of papers which fall within the scope of the ‘Luxembourg definition’ of grey literature do not pass through any extensive peer or editorial review and we do not consider them to be published in the scholarly sense.
\n\nAlthough such papers are regularly made publicly available via personal websites and institutional repositories, their general purpose is to gather comments and feedback from Authors’ colleagues in order to further improve a manuscript intended for future publication.
\n\nWhen submitting their work, Authors are required to disclose the existence of any publicly available earlier drafts in a note to the Academic Editor. In cases where earlier drafts of the submitted version of the manuscript are publicly available, any overlap between the versions will generally not be considered an instance of self-plagiarism.
\n\n4. SOCIAL MEDIA, BLOG & MESSAGE BOARD POSTINGS
\n\nWe feel that social media, blogs and message boards are generally used with the same intention as grey literature, to formulate ideas for a manuscript and gather early feedback from like-minded researchers in order to improve a particular piece of work before submitting it for publication. Therefore, we do not consider such internet postings to be publication in the scholarly sense.
\n\nNevertheless, Authors are encouraged to disclose the existence of any internet postings in which they outline and describe their research or posted passages of their manuscripts in a note to the Academic Editor. Please note that we will not strictly enforce this request in the same way that we would instructions we consider to be part of our conditions of acceptance for publication. We understand that it may be difficult to keep track of all one’s internet postings in which the researcher´s current work might be mentioned.
\n\nIn cases where there is any overlap between the Author´s submitted manuscript and related internet postings, we will generally not consider it to be an instance of self-plagiarism. This also holds true for any co-Author as well.
\n\nFor more information on this policy please contact permissions@intechopen.com.
\n\nPolicy last updated: 2017-03-20
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. 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Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/45421",hash:"",query:{},params:{id:"45421"},fullPath:"/chapters/45421",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()