\r\n\t(i) Quantum dots of very high-quality optical applications, Quantum dot light-emitting diodes (QD-LED) and ‘QD-White LED’, Quantum dot photodetectors (QDPs), Quantum dot solar cells (Photovoltaics).
\r\n
\r\n\t(ii) Quantum Computing (quantum bits or ‘qubits’), (vii) The Future of Quantum Dots (broad range of real-time applications, magnetic quantum dots & graphene quantum dots), Superconducting Loop, Quantum Entanglement, Quantum Fingerprints.
\r\n
\r\n\t(iii) Biomedical and Environmental Applications (to study intracellular processes, tumor targeting, in vivo observation of cell trafficking, diagnostics and cellular imaging at high resolutions), Bioconjugation, Cell Imaging, Photoelectrochemical Immunosensor, Membranes and Bacterial Cells, Resonance Energy-Transfer Processes, Evaluation of Drinking Water Quality, Water and Wastewater Treatment, Pollutant Control.
",isbn:"978-1-80356-594-1",printIsbn:"978-1-80356-593-4",pdfIsbn:"978-1-80356-595-8",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"0dd5611c62c91569bd2819e68852002a",bookSignature:"Prof. Jagannathan Thirumalai",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11756.jpg",keywords:"LED, Organic LEDs, Dyes & Pigments, Solar Cells, Laser Photonics, Electronic Switching Devices, Qubits, Josephson Junction, Bioconjugation, Cell Imaging, Photoelectrochemical Immunosensor, Membranes, and Bacterial Cells",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 16th 2022",dateEndSecondStepPublish:"May 27th 2022",dateEndThirdStepPublish:"July 26th 2022",dateEndFourthStepPublish:"October 14th 2022",dateEndFifthStepPublish:"December 13th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"a month",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. J. Thirumalai received his Ph.D. from Alagappa University, Karaikudi, He was also awarded the Post-doctoral Fellowship from Pohang University of Science and Technology (POSTECH), the Republic of Korea. His research interests focus on luminescence, self-assembled nanomaterials, and thin-film optoelectronic devices. He has published more than 60 SCOPUS/ISI indexed papers and 11 book chapters, edited 4 books, and member of several national and international societies like RSC, OSA, etc. His h-index is 19.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"99242",title:"Prof.",name:"Jagannathan",middleName:null,surname:"Thirumalai",slug:"jagannathan-thirumalai",fullName:"Jagannathan Thirumalai",profilePictureURL:"https://mts.intechopen.com/storage/users/99242/images/system/99242.png",biography:"Dr. J. Thirumalai received his Ph.D. from Alagappa University, Karaikudi in 2010. He was also awarded the Post-doctoral Fellowship from Pohang University of Science and Technology (POSTECH), Republic of Korea, in 2013. He worked as Assistant Professor of Physics, B.S. Abdur Rahman University, Chennai, India (2011 to 2016). Currently, he is working as Senior Assistant Professor of Physics, Srinivasa Ramanujan Centre, SASTRA Deemed University, Kumbakonam (T.N.), India. His research interests focus on luminescence, self-assembled nanomaterials, and thin film opto-electronic devices. He has published more than 60 SCOPUS/ISI indexed papers and 11 book chapters, edited 4 books and member in several national and international societies like RSC, OSA, etc. Currently, he served as a principal investigator for a funded project towards the application of luminescence based thin film opto-electronic devices, funded by the Science and Engineering Research Board (SERB), India. As an expert in opto-electronics and nanotechnology area, he has been invited as external and internal examiners to MSc and PhD theses, invited to give talk in some forum, review papers for international and national journals.",institutionString:"SASTRA University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"10",totalChapterViews:"0",totalEditedBooks:"6",institution:null}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"17",title:"Nanotechnology and Nanomaterials",slug:"nanotechnology-and-nanomaterials"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"347258",firstName:"Marica",lastName:"Novakovic",middleName:null,title:"Ms.",imageUrl:"//cdnintech.com/web/frontend/www/assets/author.svg",email:"marica@intechopen.com",biography:null}},relatedBooks:[{type:"book",id:"5348",title:"Luminescence",subtitle:"An 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1. Introduction
Dual wavelength fiber lasers (DWFL) research has increased considerably in recent years due to the potential applications of these optical devices in diverse investigation areas. Interest of use of DWFL includes areas such as fiber sensors, wavelength division multiplexing, optical communications systems, optical instrumentation and recently in microwaves generation [1-4], among others.
DWFL are considered profitable optical sources because of their advantages such as low cost, easy and affordable optical structures, low losses insertion and space optimization. Principal issue to generate two simultaneous laser lines resides in the cavity losses adjustment. In DWFL designed with Erbium-doped fiber (EDF) as a gain medium there is a strong competition between the generated laser lines due to the EDF’s homogeneous gain medium behavior at room temperature. To reduce the competition between the wavelengths, several techniques have been reported aiming to achieve stable multi-wavelength laser oscillations [5-8].
Moreover, fiber Bragg gratings (FBG) have been extensively used in DWFL cavities design due to their advantages as optical devices including easy manufacture, fiber compatibility, low cost and wavelength selection among others. FBG’s wavelength selection property is commonly used as a narrow band reflector inside the laser cavity to generate a laser line at a specific wavelength. Several DWFL experimental setups using FBG’s have been reported including use of a FBG written in a high birefringence or in a multimode fiber [6-11].
In a large majority of DWFL using EDF and FBG’s, the laser cavity losses correspond to different generated laser lines at a specific wavelength position over the gain medium spectrum. The generated wavelength should be balanced to achieve two simultaneous laser lines. Consequently, both oscillation lines have the same pump threshold. Commonly the wavelengths adjustment is realized through arbitrary methods as use of polarization controllers (PC) and variable optical attenuators (VOA) [7, 12, 13]. With the progress on DWFL research studies have been followed two different pathways in order to enhance stability of the simultaneously generated laser lines by improving the cavity losses adjustment methods.
On the one hand, the research focuses on incorporating of cutting-edge devices in an effort to obtain more stable and efficient dual laser emissions. In such a way that these researching works reports the use of newly developed optical fibers such as photonic crystal fibers, leading to use optical devices that allow the exploit of nonlinear optics [14-16]. Most of the reported works on this area tend to have more complex designs and non-straightforward settings. By the other hand, a second pathway is in function of simplicity and optimization of laser cavity length, taking into account that a reduced cavity length implies a decrease of laser modes within the cavity, allowing, in a first instance analysis, a dual laser emission with lower instability, a simple adjustment of the competition between laser lines with a substantial reduction of implementation space that can improve the results repeatability [17, 18].
In recent years, obtaining of dual-wavelength laser emission does not represent an advance by itself in DWFL progress because the increasing need to analyze the behavior of the competition between the generated laser lines obtained by the cavity losses adjustment methods. Using arbitrary methods like adjustment by polarization controllers and variable optical attenuators do not allow a behavioral analysis of the competition between generated wavelengths because these methods do not have a measurable physical variable to characterize the adjustment and difficultly can provide repeatability in results.
The spectral selectivity of the interferometer is caused by birefringence that has to be introduced to the loop. A lot of effort has been made to suggest and investigate a variety of FOLM designs. Ma et al. [20] demonstrated polarization independence of the Hi-Bi FOLM. Liu et al. [21] reported a study of an optical filter consisting of two concatenated Hi-Bi FOLMs. Lim et al. [22] analyzed the behavior of an FOLM with a fiber loop consisting of two Hi-Bi fibers connected in series. The transmittance spectrum of the FOLM presents a periodic behavior with maxima and minima depending on the Hi-Bi fiber length and birefringence. For dual-wavelength lasers, low contrast offers the advantage of smoother cavity loss adjustment for the generated wavelengths where the principal mechanism of the adjustment of the cavity loss is the shift of the wavelength of the reflection maxima of the FOLM. The wavelength shift is achieved by the change of the temperature of the Hi-Bi fiber. This method allows generating two wavelengths with a well-controlled ratio between their powers [19].
Moreover, the tuning of the laser generated wavelengths promises to be an advantage for DWFL microwave generation application making it possible through the tuning of separation between wavelengths. A simple method of wavelength tuning is related to the Bragg period modification of a FBG. Wavelength tunable DWFL were reported [16-19]. In most configurations the FBG’s are used with Bragg wavelength shift by temperature change [23], compression or stretch [18, 24]. Most of the techniques reported before as a matter of fact realize an adjustment of the losses between the two wavelengths to achieve stable dual-wavelength generation. In spite of the numerous papers reporting dual-wavelength generation, to the best of our knowledge no investigations were reported on the relation between the losses for generated wavelengths that enables simultaneous dual-wavelength generation.
M. A. Mirza [25] in 2008 presented the theoretical and experimental analysis of the design of a Sagnac loop filter (SLF) with periodic output spectrum controlled by cascading a small birefringence loop (SBL) with a high birefringence loop (HBL) with a tuning of the amplitude and wavelength of the spectrum of the filter through mechanical rotation. In this work is mentioned that the proposed design may have potential application in the design of Erbium-doped fiber lasers for multiple wavelengths generation in the C band and also can be used as a tuning tool for competition between the generated laser lines.
H. B. Sun [26] published in 2010 a DWFL with wide tuning based on a Hi-Bi FOLM and the use of polarization controllers inside the loop for adjustment of the loss within the ring cavity proposed. The laser wavelength can be tuned flexibly within the range of 1525 nm to 1575 nm by adjusting the polarization controller. The separation between the two generated wavelengths is adjustable by changing the length of the Hi-Bi fiber of the FOLM loop. Also proves the modes stability of the two laser lines at room temperature with a variation of the peak output power of about 0.5 dB over 40 minutes of operation.
K. J. Zhou [27] in 2012 reported the use of an all-PM Sagnac loop periodic filter as a frequency selector in a Erbium-doped fiber ring laser. The laser with a 1 nm interval filter generates four simultaneous and stable wavelengths with equal frequency spacing to overcome the homogeneous broadening of Erbium-doped fiber as a gain medium at room temperature. Polarizer controllers are used inside the ring cavity to adjust the laser lines emissions. The experiment confirm that this kind of filter should be robust to environmental changes.
This chapter proposes the application of a Sagnac fiber optical loop mirror with a high-birefringence fiber on the loop (Hi-Bi FOLM) used as a spectral filter to adjust finely the laser cavity losses, reducing the competition between generated laser wavelengths by temperature variations on the FOLM fiber loop. This control allows characterizing the competition behavior with temperature variations to achieve a better adjustment to obtain dual-wavelength laser emission. The appropriate choice of the angles of both ends of the Hi-Bi fiber allows a reflection minimum between 0 and 0.9 without substantial wavelength shift. The reflection maximum is always equal to 1 [19].
In this chapter the application of an all-fiber Hi-Bi FOLM to balance the losses within a dual-wavelength fiber laser is presented. An analysis of the losses is performed by charactering the FBG’s reflections over the transmission spectrum of the FOLM when the laser wavelengths are generated, allowing the study of the fine adjustment of the FOLM transmission spectrum wavelength shift by temperature variation in the Hi-Bi fiber loop of the FOLM necessary to achieve dual-wavelength laser emission.
2. Numerical analysis of Sagnac Hi-Bi FOLM for dual-wavelength laser application
Numerically analysis for variation of the transmission spectrum of a Hi-Bi FOLM with the twist of the fiber in the loop can be an important tool for dual-wavelength fiber lasers design. The Hi-Bi FOLM shown in Figure 1 consists of a fiber coupler with a coupling ratio of α/1−α, which is assumed to be independent of wavelength. The output ports (3 and 4) are fusion spliced to a Hi-Bi fiber with arbitrary angles between the axes of the Hi-Bi fiber and the axes of the coupler ports. The segments where the Hi-Bi fiber is spliced to the coupler ports are placed on rotation stages. The Hi-Bi fiber is placed on a thermoelectric cooler to shift the wavelength dependence of the filter transmission. A light beam with electric field Ei enters through port 1; the transmitted beam with electric field ET exits from port 2.
Figure 1.
High birefringence fiber optical loop mirror
To calculate the transmission of the FOLM, we used the approach developed by Mortimore [28]. For a single input field Ei, a transmitted field ET is given by:
where the J matrix is calculated as the product of matrices corresponding to all elements in the loop:
J=U1⋅C1⋅U2⋅C2⋅U3,E2
where matrices U1 and U3 represent the coupler ports; the matrices C1 and C2 represent the coordinate rotation accounting for the angles between the axes of the Hi-Bi fiber and those of the coupler ports at the splices; finally, the matrix U2 represents the Hi-Bi fiber. The analysis of the matrices that form the Jones matrix for the Hi-Bi FOLM is presented in detail in reference [19], where matrices U1, U2 and U3 take into account linear birefringence of the fibers and the circular birefringence caused by the fiber twist angle. Matrices C1 and C2 transform the Jones vectors from the Cartesian system related with the axes of the port to that related with the axes of the Hi-Bi fiber.
Transmission spectrum of the Hi-Bi FOLM is a periodic function whose period is given by the following expression:
Δλ=λ2B⋅L,E3
where B is the fiber loop birefringence, Lthe fiber loop length and λ the wavelength.
The values of the transmission minima are defined by the coupling ratio and are equal to, the transmission maxima however depends on the rotation of the rotational stages and can be adjusted in the range between (2α−1)2 and 1 [29]. The adjustment of the values of the transmission maxima can be useful in particularly for dual wavelength laser application. However the rotation of the rotational stages also moves the wavelengths of the maxima and minima.
The numerical simulation for calculated transmission spectrum was performed. The coupler ports with a length of 0.5-m and a beat length of 6 m was used. The length of the Hi-Bi fiber is equal to 28 cm with a beat length of 3.6×10−3 m. The angles θ1 = 0.5π and θ2 = 0.3π were taken arbitrarily. To obtain the transmission maximum equal to 1 the angles ϕ1 and ϕ2 were adjusted with ϕ2=−0.8π. Figure 2 shows transmission spectra for angle φ1 variations in the range between 0 and 1.087π. Transmission maximum depends on the period ϕ1=1.087π. Here we can see than the adjustment of the transmission maximum by angle ϕ1 variations also causes a wavelength shift of the transmission spectra that depends on the birefringence of the coupler ports.
Figure 3 shows the wavelength as the angle ϕ1 is varied for different beat lengths of the coupler ports with the same simulation parameters. In a range of the angle ϕ1 approximately between 0.2π and 0.8π the wavelength shift is less than 1 nm. The wavelength shift is more pronounced for larger birefringence of the coupler ports.
Figure 2.
FOLM transmission spectra as a function of angle ф1 with fixed ф2.
The Hi-Bi FOLM transmission spectra amplitude adjustment causes a shift of the maximum/minimum in the reflection spectrum that is undesirable for dual-wavelength laser applications. However, the appropriate choice of the angles of both ends of the Hi-Bi fiber allows a reflection minimum between 0 and 0.9 without substantial wavelength shift. The twist of the fiber offers a simple way to change the ratio between the reflection maximum and minimum that provides a useful and simple method for the FOLM contrast adjustment.
3. Sagnac Hi-Bi FOLM charactization for dual-wavelength laser application
For the experimental investigation we introduce the basic experimental setup used. The all-fiber Fabry-Perot cavity laser is limited at one end by two Bragg gratings and at the opposite end by a Hi-Bi FOLM. Figure 4 shows the configuration where the laser gain medium is EDF with a length of 10-m. The two FBGs at one end of the cavity have 55.4% of maximum reflection at 1547.94 nm and 1546.96 nm to 59.75% respectively. The optical attenuator (OA) is achieved through the introduction of bend loss between the FBG’s in a fiber section wounded approximately 6 turns in a circular piece with a 5-cm diameter. The adjustment of the turns was experimentally obtained at a point where both wavelengths (corresponding to FBG1 and FBG2 maxima) compete for the gain of the active medium. With this method we are roughly adjusting the losses within the cavity. The fine cavity loss adjustment is achieved by the FOLM formed by a 3dB optical coupler (Coupler 2) with the output ports interconnected through a high birefringence fiber with 28-cm length.
Figure 3.
Dependence of the wavelength shift of the transmission maximum on the angle ф1 for different beat lengths Lb.
The EDF is pumped by a 50-mW laser diode at 980-nm through a 980/1550 wavelength division multiplexer (WDM). Coupler 1 is a 90/10 coupling ratio optical coupler used to measure the 10% laser output at Output B, detecting only reflected wavelengths from FBG1 and FBG2. The output signal is launched to a 0.2-nm resolution monochromator, detected by a photodetector and monitored by an oscilloscope. Output A is used to measure the FOLM transmission spectrum at low pump power (below the threshold). Both laser wavelengths and ASE can be detected at this output.
The splices were placed into rotation stages to adjust the transmission of the FOLM. The Hi-Bi fiber temperature is controlled by temperature controller with a precision of 0.1 °C for the purpose of tuning the wavelength of the transmission spectra. The Hi-Bi fiber loop is placed on a thermoelectric cooler (TEC) whose temperature can be adjusted in the range between room temperature (about 25 °C) and 9 °C.
Measure of Hi-Bi FOLM transmission at temperatures in a range between 9 and 20°C was performed. Figure 5 shows the Hi-Bi FOLM transmission for Hi-Bi fiber loop temperatures of 9 and 11°C measured at Output A for low pump power. As it can be seen the transmission curve is shifted towards longer wavelengths when the temperature is decreased however the period remains equal to 20.8-nm. The contrast adjustment by rotation angles twist is near to the maximal contrast.
Figure 4.
Experimental setup for the dual-wavelength fiber laser.
Figure 5.
Hi-Bi FOLM transmission spectra wavelength shift by fiber loop temperature variation.
The wavelength dependence shift of the FOLM transmission on Hi-Bi fiber loop temperature is shown on Figure 6. The wavelength shift is well fitted by a linear dependence with a slope of -1.71 nm/°C shown with dashed line, which yields a temperature period equal to 13 °C.
Figure 6.
Wavelength displacement for Hi-Bi fiber loop temperature variations.
Figure 7 shows output signal spectrum at the output A for the fiber Sagnac loop with a pump power of 25-mW, which is below the threshold for generating laser amplification. The measurement was performed with a temperature of 22.7 °C. Rotation angles adjustment is close to a minimum FOLM spectra output with ϕ1=40o (angle which we take as zero for rotation ϕ1, we rotate 180° in ϕ1 from this position of the rotator C1) and ϕ2=120o reference to the axis of laboratory table. With fixed ϕ2, rotation is performed in ϕ1 with a 15° step.
Figure 7.
Spectrum at the FOLM output for different angles ф1 with fixed ф2.
The FOLM transmission presents periodic wavelength dependence with a period of 20.8 nm. It can be seen that the position of the maximum is shifted when the angle ϕ1 is changed. The maximum is connected by a solid line in Figure 7. However, the period remains the same.
Figure 8.
Dependence of wavelength shift of the transmission maximum and minimum on the angle ф1 with ф2=55°.
Figure 8 shows the wavelength shift of the maximum and the minimum of transmission due to the variation of the ϕ1 angle for an angle ϕ2 adjustment to 55°. The angle ϕ1 was referred as 0 in the same manner as for Figure 7. The experimental dependences show a behavior similar to that obtained in simulations in Figure 3. It can be seen that there exists a range of the angle from about 60° to 180° where the dependence of the wavelength shift is almost flat with variations of less than 0.5-nm (corresponding to only a few percent of the transmission period).
The FOLM is used to adjust the loss of the cavity for wavelengths λ1 and λ2 corresponding to the FBG1 and FBG2 to obtain dual-wavelength operation. The application of the FOLM for dual-wavelength lasers was reported for the first time in Ref. [30].
4. Dual-wavelength fiber laser cavity loss fine adjustment by Sagnac Hi-Bi FOLM
Figure 8 presents the laser spectrum for different temperatures of the Hi-Bi fiber with the experimental setup shown in Figure 4. Laser output is measured in Output B for a pump power of 50-mW. The temperature of the Hi-Bi fiber was chosen to have a maximum of reflection of the FOLM close to the wavelengths of maximal reflection of the FBG’s. Rotation stages fiber twist is set near to the 70% of FOLM transmission spectrum amplitude contrast. A change of the temperature moves the maxima of FOLM transmission and so changes the ratio between the reflections for λ1 and λ2.
Figure 9.
Measured output laser spectra for different Hi-Bi FOLM fiber loop temperatures.
As can be seen at the temperature of 12.0 °C two peaks are still observed however the amplitude of the peak with shorter wavelength is less than that of the peak with longer wavelength. At the temperature of 12.1 °C two peaks with equal amplitudes were observed. The increase of temperature to 12.2 °C results in a lower amplitude of the peak with longer wavelength. Finally for the temperature shift larger than 0.2 °C only one wavelength is generated by the laser, the shorter wavelength at 12.3 °C and for the longer wavelength at 11.9 °C.
Here we show the usefulness of the adjustment of the values of the reflection maxima by tuning the angles of the rotation stages. Figure 10a shows the laser transmission spectra obtained with the FOLM at high contrast between maxima and minima of reflection, while Figure 10b shows the results obtained with low contrast with the change of contrast achieved through a rotation of the rotational stages. In the results with lower contrast (Figure 10b) the dependence of the reflection on the temperature is slower, then, the range of temperatures over which dual-wavelength generation is observed is larger than in Figure 10a, providing higher tolerance with respect to the temperature stability. In figure 10a the FOLM spectrum was adjusted to have the highest contrast between the reflection maximum and minimum with ϕ1=120°. In figure 10b results, the FOLM spectrum was adjusted to have a low contrast with ϕ1=30°.
Figure 10.
Laser output spectra at different temperatures with different contrasts.
Figure 11 shows the measured power of the two laser lines for the same FOLM adjustment as for Figures 10a and 10b for the maximal transmission amplitude point. Insets in the figures show reflection of the FOLM used for each measurement. We can see that the temperature tolerance of the dual-wavelength operation for the case shown in Figure 11b is much higher than the temperature tolerance for the case shown in Fig. 11a.
Figure 11.
Power at wavelengths λ1 and λ2. (a) Highest contrast between reflection maxima and minima, (b) low contrast between reflection maxima and minima.
For dual-wavelength lasers, low contrast offers the advantage of smoother cavity loss adjustment for the generated wavelengths where the principal mechanism of the adjustment of the cavity loss is the shift of the wavelength of the reflection maxima of the FOLM. The wavelength shift is achieved by the change of the temperature of the Hi-Bi fiber. This method allows generating two wavelengths with a well-controlled ratio between their powers.
5. Tunable dual-wavelength fiber laser with Sagnac Hi-Bi FOLM and a polarization-maintaining FBG
Here, experimentally operation of a linear cavity dual-wavelength fiber laser using a polarization maintaining fiber Bragg grating (PM-FBG) is presented. PM-FBG is used as an end mirror that defines two closely spaced laser emission lines and it is also used to tune the laser wavelengths. The total tuning range is around 8 nm. The laser operates in a stable dual-wavelength mode for an appropriate adjustment of the cavity losses for the generated wavelengths. The high birefringence (Hi-Bi) fiber optical loop mirror (FOLM) is used as a tunable spectral filter to adjust the losses as can be seen before in topics 3 and 4 [31].
The experimental setup used is similar to in figure 4 and it can be seen in figure 12. The linear laser cavity is formed by the Hi-Bi FOLM analyzed before and a PM-FBG mounted in a mechanical device allowing compression/stretch and a polarization controller (PC). The PM-FBG spectrum presents two peaks with separation of 0.3-nm centered at 1549 nm. Both peaks have 99.5% maximum reflection. The 90/10 coupler is used as the laser output (Output A). The output radiation was launched to a monochromator with 0.1-nm of resolution, detected by a photodetector and monitored by an oscilloscope. Output B is used to monitor FOLM transmission spectra.
Figure 12.
Tunable dual-wavelength fiber laser with PM-FBG experimental setup.
The laser cavity is set to have the transmission minimum at approximately 1549 nm where the PM-FBG reflection is centered by temperature variations of the Hi-Bi FOLM fiber loop.
Figure 13 shows the reflection spectrum of the PM-FBG and ASE at Output B for a pump power near the laser threshold (around 25-mW) and a temperature of 24.5 °C. No strain is applied to the PM-FBG then, PM-FBG reflection peak is centered at 1549 nm.
Figure 13a shows the FOLM transmission spectrum for a high contrast between minima and maxima of reflection. Figure 13b shows the FOLM transmission spectrum for a low contrast adjustment. The low contrast adjustment allows a smoother change of the FOLM reflection with temperature such that this is the adjustment of contrast used in measurements of the generation of laser lines.
Figure 13.
Measured Hi-Bi FOLM transmission spectra at Output B. (a) High contrast adjustment. (b) Low contrast adjustment.
For dual-wavelength generated laser lines measurement, both laser lines at 1548.86 and 1549.18 nm are monitored at Output A. Adjust of PC allows to obtain stable dual wavelength generation. However the compression/stretch of the PM-FBG causes the loss of the dual wavelength generation and further adjustment of the PC is required. The adjustment of the PC however is not a straightforward procedure. An adjustment of the temperature of the Hi-Bi fiber in the FOLM was performed then. Figure 14 shows the shift of the two wavelengths for different values of compression/stretch applied to the PM-FBG. Micrometer screw positions are shown in the graphics; negative values are assigned to the compression, positive to the stretch.
Figure 14.
Fiber laser spectra at the compressed/stretched PM-FBG.
The resolution of the monochromator was not sufficient to measure the bandwidth of lines. To be sure that we have two well separated laser lines we monitored the output also with a scanning Fabry–Perot.
Figure 15.
Output signal from the Fabry-Perot scanning with no strain applied to the PM-FBG.
Figure 15 shows the oscilloscope trace of the signal at the FP output with no strain applied to the PM-FBG. As can be seen there are two well separated lines with separation of 0.34 nm. The free space of FP shown in the inset is equal to 0.6 nm. The total power inside the cavity is about 1-mW and was measured at the output A through a photodetector and an optical power meter.
Axial compression or stretch was applied by using a micrometric screw mechanical system. The maximum compression applied was 50 μm causing a maximum wavelength displacement of 5.5 nm. The corresponding wavelengths shift rate is about 1.1 nm/10 μm. The maximum stretch was 30 μm, causing a wavelength shift of about 2.58 nm, which corresponds to a rate of 0.86 nm/10 μm. The total laser wavelength shift is 8.09 nm with average rate of 1 nm/10 μm approximately. For each compression/stretch of the PM-FBG we adjusted the temperature of the Hi-Bi fiber to obtain dual-wavelength generation.
Figure 16 shows the temperature required for dual-wavelength generation. As one see the dependence is well fitted linearly with a slope of –1.39 nm/°C so the adjustment procedure is very simple and straightforward.
Figure 16.
Required Hi-Bi FOLM temperature for dual-wavelength laser operation at stretched/compressed PM-FBG.
This method allows to estimate a reflection change for shorter and longer wavelengths of the PM-FBG under compression/stretch. Figure 17 shows the FOLM minimum transmission wavelength and the central wavelength of the dual line laser. If the wavelength of the FOLM minimum transmission coincides with the central wavelength of the laser, the reflection of the FOLM is equal for both wavelengths. We observe this for compression/stretch around 0.
Figure 17.
Wavelengths of the FOLM minimum transmission and lasing central wavelengths at the stretched/compressed PM-FBG.
To have dual wavelength generation under compression or stretch the minimum of the FOLM transmission (corresponding to maximum reflection) has to be displaced to shorter wavelength with respect to the central lasing wavelength, which means that the FOLM reflection for the shorter wavelength line is slightly higher than the reflection for the longer wavelength.
From this we can conclude that the reflection of the PM-FBG for shorter wavelength line became slightly smaller at compression/stretch than for the longer wavelength line.
6. Conclusions
In the first part we present numerical and experimental analysis of a high birefringence fiber optical loop mirror (Hi-Bi FOLM) to use in lasers with dual wavelength. The adjustment in the amplitude spectrum because of the reflectivity was considered as a tool for the dual wavelength laser stability. This is accomplished by adjusting the angles in one of the ports of the FOLM where we in which we may have a minimum and maximum of reflectivity the laser cavity. Also that we can select the best performing region in terms of period, amplitude spectrum of the FOLM and by temperature we can shift the wavelength in the FOLM and equalize the two wavelengths required to generate a laser with dual wavelength emission.
In the second part we propose to apply the FOLM to generate a laser with dual wavelength emission. We propose and demonstrate experimentally a laser with dual wavelength and stable, we can make the laser having laser emission at single or dual wavelength by adjusting the temperature in the loop FOLM and we demonstrate how to improve the stability of the laser by adjusting the amplitude using the optical fiber twisters in the FOLM.
In the third part we explain the implementation of the FOLM to generate tunable dual wavelength using a polarizer maintaining fiber Bragg grating (PM-FBG). We propose and demonstrate experimentally a tunable wavelength laser. The tuning range was 8.06-nm; this tuning was achieved by stretching and compressing the PM-FBG. For each tuning was only necessary to adjust the temperature in the FOLM. As a result of this application of the FOLM to generate a dual wavelength laser, we present two simple configurations that can be used for future applications.
Acknowledgments
This work is supported by CONACYT grant 151434.
\n',keywords:null,chapterPDFUrl:"https://cdn.intechopen.com/pdfs/45077.pdf",chapterXML:"https://mts.intechopen.com/source/xml/45077.xml",downloadPdfUrl:"/chapter/pdf-download/45077",previewPdfUrl:"/chapter/pdf-preview/45077",totalDownloads:2134,totalViews:256,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:8,impactScoreQuartile:1,hasAltmetrics:0,dateSubmitted:"May 2nd 2012",dateReviewed:"October 14th 2012",datePrePublished:null,datePublished:"June 13th 2013",dateFinished:"May 29th 2013",readingETA:"0",abstract:null,reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/45077",risUrl:"/chapter/ris/45077",book:{id:"3360",slug:"current-developments-in-optical-fiber-technology"},signatures:"Manuel Durán-Sánchez, R. Iván Álvarez-Tamayo, Evgeny A. Kuzin,\nBaldemar Ibarra-Escamilla, Andrés González-García and Olivier\nPottiez",authors:[{id:"157870",title:"Dr.",name:"Manuel",middleName:null,surname:"Durán Sánchez",fullName:"Manuel Durán Sánchez",slug:"manuel-duran-sanchez",email:"maratonista80@hotmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Instituto Tecnológico de Puebla",institutionURL:null,country:{name:"Mexico"}}},{id:"160257",title:"Mr.",name:"Ricardo Ivan",middleName:null,surname:"Alvarez Tamayo",fullName:"Ricardo Ivan Alvarez Tamayo",slug:"ricardo-ivan-alvarez-tamayo",email:"alvarez.tamayo@hotmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"160259",title:"Dr.",name:"Evgeny",middleName:null,surname:"Kuzin",fullName:"Evgeny Kuzin",slug:"evgeny-kuzin",email:"ekuz@inaoep.mx",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"160260",title:"Dr.",name:"Baldemar",middleName:null,surname:"Ibarra Escamilla",fullName:"Baldemar Ibarra Escamilla",slug:"baldemar-ibarra-escamilla",email:"baldemar@inaoep.mx",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"160261",title:"Dr.",name:"Andres",middleName:null,surname:"Gonzalez Garcia",fullName:"Andres Gonzalez Garcia",slug:"andres-gonzalez-garcia",email:"aglez@inaoep.mx",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"160262",title:"Dr.",name:"Olivier Jean Michel",middleName:null,surname:"Pottiez",fullName:"Olivier Jean Michel Pottiez",slug:"olivier-jean-michel-pottiez",email:"pottiez@cio.mx",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Numerical analysis of Sagnac Hi-Bi FOLM for dual-wavelength laser application",level:"1"},{id:"sec_3",title:"3. Sagnac Hi-Bi FOLM charactization for dual-wavelength laser application",level:"1"},{id:"sec_4",title:"4. Dual-wavelength fiber laser cavity loss fine adjustment by Sagnac Hi-Bi FOLM",level:"1"},{id:"sec_5",title:"5. Tunable dual-wavelength fiber laser with Sagnac Hi-Bi FOLM and a polarization-maintaining FBG",level:"1"},{id:"sec_6",title:"6. Conclusions",level:"1"},{id:"sec_7",title:"Acknowledgments",level:"1"}],chapterReferences:[{id:"B1",body:'Talaverano L., Abad S., Jarabo S., and Lopez-Amo M. Multiwavelength fiber laser souces with Bragg-grating sensor multiplexing capability. J. Lightwave Technology 2001; 19(4) 553-558.'},{id:"B2",body:'Liu D., Ngo N. Q., Tjin S. C., and Dong X. A dual-wavelength fiber laser sensor system for measurement of temperature and strain. 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Optics Communications 1999; 160 37-41 (1999)'},{id:"B30",body:'Durán-Sánchez M., Flores-Rosas A., Alvarez-Tamayo R. I., Kuzin E. A., Pottiez O., Bello-Jimenez M., Ibarra- Escamilla B. Fine adjustment of cavity loss by Sagnac loop for a dual wavelength generation. Laser Physics 2010; 20(5) 1270–1273.'},{id:"B31",body:'Alvarez-Tamayo R. I., Durán-Sánchez M., Pottiez O., Kuzin E. A., Ibarra-Escamilla B. Tunable Dual-Wavelength Fiber Laser Based on a Polarization-Maintaining Fiber Bragg Grating and a Hi-Bi Fiber Optical Loop Mirror. Laser Physics 2011; 21(11) 1932-1935.'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Manuel Durán-Sánchez",address:null,affiliation:'
Mecatrónica, Universidad Tecnológica de Puebla (UTP), Puebla, México
Departamento de Fibras Ópticas, Centro de Investigaciones, en Óptica (CIO), León, Guanajuato, México
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Maxwell, Pavel Klang, Werner Schrenk and Gottfried Strasser",authors:[{id:"4537",title:"DI",name:"Alexander",middleName:null,surname:"Benz",fullName:"Alexander Benz",slug:"alexander-benz"},{id:"135394",title:"Prof.",name:"Christoph",middleName:null,surname:"Deutsch",fullName:"Christoph Deutsch",slug:"christoph-deutsch"},{id:"135395",title:"Prof.",name:"Gernot",middleName:null,surname:"Fasching",fullName:"Gernot Fasching",slug:"gernot-fasching"},{id:"135396",title:"Prof.",name:"Karl",middleName:null,surname:"Unterrainer",fullName:"Karl Unterrainer",slug:"karl-unterrainer"},{id:"135397",title:"Prof.",name:"Aaron",middleName:null,surname:"Maxwell",fullName:"Aaron Maxwell",slug:"aaron-maxwell"},{id:"135398",title:"Prof.",name:"Pavel",middleName:null,surname:"Klang",fullName:"Pavel Klang",slug:"pavel-klang"},{id:"135399",title:"Prof.",name:"Werner",middleName:null,surname:"Schrenk",fullName:"Werner Schrenk",slug:"werner-schrenk"},{id:"135400",title:"Prof.",name:"Gottfried",middleName:null,surname:"Strasser",fullName:"Gottfried Strasser",slug:"gottfried-strasser"}]},{id:"8448",title:"High-Power and High Efficiency Yb:YAG Ceramic Laser at Room Temperature",slug:"high-power-and-high-efficiency-yb-yag-ceramic-laser-at-room-temperature",signatures:"Shinki Nakamura",authors:[{id:"4143",title:"Dr.",name:"Shinki",middleName:null,surname:"Nakamura",fullName:"Shinki Nakamura",slug:"shinki-nakamura"}]},{id:"8449",title:"Polarization Properties of Laser-Diode-Pumped Microchip Nd:YAG Ceramic Lasers",slug:"polarization-properties-of-laser-diode-pumped-microchip-nd-yag-ceramic-lasers",signatures:"Kenju Otsuka",authors:[{id:"4259",title:"Professor",name:"Kenju",middleName:null,surname:"Otsuka",fullName:"Kenju Otsuka",slug:"kenju-otsuka"}]},{id:"8450",title:"Surface-Emitting Circular Bragg Lasers – A Promising Next-Generation On-Chip Light Source for Optical Communications",slug:"surface-emitting-circular-bragg-lasers-a-promising-next-generation-on-chip-light-source-for-optical-",signatures:"Xiankai Sun and Amnon Yariv",authors:[{id:"4201",title:"Prof.",name:"Xiankai",middleName:null,surname:"Sun",fullName:"Xiankai Sun",slug:"xiankai-sun"},{id:"122981",title:"Dr.",name:"Amnon",middleName:null,surname:"Yariv",fullName:"Amnon Yariv",slug:"amnon-yariv"}]},{id:"8451",title:"Novel Enabling Technologies for Convergence of Optical and Wireless Access Networks",slug:"novel-enabling-technologies-for-convergence-of-optical-and-wireless-access-networks",signatures:"Jianjun Yu, Gee-Kung Chang, Zhensheng Jia and Lin Chen",authors:[{id:"8503",title:"Dr.",name:"Jianjun",middleName:null,surname:"Yu",fullName:"Jianjun Yu",slug:"jianjun-yu"},{id:"133376",title:"Prof.",name:"Gee-Kung",middleName:null,surname:"Chang",fullName:"Gee-Kung Chang",slug:"gee-kung-chang"},{id:"133378",title:"Prof.",name:"Zhensheng",middleName:null,surname:"Jia",fullName:"Zhensheng Jia",slug:"zhensheng-jia"},{id:"139599",title:"Prof.",name:"Lin",middleName:null,surname:"Chen",fullName:"Lin Chen",slug:"lin-chen"}]},{id:"8452",title:"Photonic Crystal Multiplexer/Demultiplexer Device for Optical Communications",slug:"photonic-crystal-multiplexer-demultiplexer-device-for-optical-communications",signatures:"Sahbuddin Shaari and Azliza J. M. Adnan",authors:[{id:"19951",title:"Dr.",name:"Sahbudin",middleName:null,surname:"Shaari",fullName:"Sahbudin Shaari",slug:"sahbudin-shaari"}]},{id:"8453",title:"Improvement Scheme for Directly Modulated Fiber Optical CATV System Performances",slug:"improvement-scheme-for-directly-modulated-fiber-optical-catv-system-performances",signatures:"Hai-Han Lu, Ching-Hung Chang and Peng-Chun Peng",authors:[{id:"4684",title:"Professor",name:"Hai-Han",middleName:null,surname:"Lu",fullName:"Hai-Han Lu",slug:"hai-han-lu"},{id:"62688",title:"Prof.",name:"Peng-Chun",middleName:null,surname:"Peng",fullName:"Peng-Chun Peng",slug:"peng-chun-peng"}]},{id:"8454",title:"Optical Beam Steering Using a 2D MEMS Scanner",slug:"optical-beam-steering-using-a-2d-mems-scanner",signatures:"Yves Pétremand, Pierre-André Clerc, Marc Epitaux, Ralf Hauffe, Wilfried Noell and N.F. de Rooij",authors:[{id:"5054",title:"Dr.",name:"Yves",middleName:null,surname:"Petremand",fullName:"Yves Petremand",slug:"yves-petremand"},{id:"135512",title:"Prof.",name:"Pierre-Andre",middleName:null,surname:"Clerc",fullName:"Pierre-Andre Clerc",slug:"pierre-andre-clerc"},{id:"135514",title:"Prof.",name:"Marc",middleName:null,surname:"Epitaux",fullName:"Marc Epitaux",slug:"marc-epitaux"},{id:"135516",title:"Prof.",name:"Ralf",middleName:null,surname:"Hauffe",fullName:"Ralf Hauffe",slug:"ralf-hauffe"},{id:"135518",title:"Prof.",name:"Wilfried",middleName:null,surname:"Noell",fullName:"Wilfried Noell",slug:"wilfried-noell"},{id:"135519",title:"Prof.",name:"N.F.",middleName:null,surname:"De Rooij",fullName:"N.F. 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1. Aging
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Aging of the population is one of the greatest current challenges because this implies a social transformation that includes work, economic, social protection, home, and coverage in health services. According to the data of World Population Prospects, the 2017 revision, it has been considered that most of the population has a life expectancy equal to or greater than 60 years, which is growing faster than the younger groups, and has estimated that by 2050, this group would increase globally to 2.1 billion, as well as 3.1 billion in 2100 [1].
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1.1 Characteristics of aging
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In the context of aging, physiological problems affect the brain. It has been considered that cognitive impairment and gait changes are the most significant since they have a high impact on the quality of life, so there is currently evidence in favor of neuroprotective strategies such as diet and exercise, especially in neurological diseases [2]. In recent years, it has increased the empirical evidence that suggests that the aging process could be delayed and, therefore, increase life expectancy accompanied by improvements in healthy lifestyle habits [3]. Likewise, advances in technological development have allowed the implementation of easy-to-use and adaptable devices to identify subtle markers of early symptoms that could be useful for designing intervention or stimulation programs in such a way as to positively influence the healthy aging process.
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In advanced ages, a decline in sensorimotor functioning and control ensues. The causes of these deficits can be multifactorial and involve the central nervous system, sensory receptors, muscles, and peripheral nerves [4]. Falls are a frequent problem in the elderly population, and it has been determined that many of these occur in the context of walking. Older adults have less dynamic stability during walking due to the deterioration in the sensitivity of the body as well as the movement of the trunk in response to small disturbances that may occur during walking [5]. This deterioration in fine motor control, gait, and balance affects the ability of older adults to independently execute the activities of daily life which affects their autonomy and functionality. However, it is important to establish that gait and mobility are not the same thing. In gait, there is a bipedal activity in which the center of gravity moves forward and includes two components: (1) the locomotion as the ability to initiate and maintain the rhythmicity in the steps and (2) the balance that is the ability to maintain the balance and posture. On the other hand, mobility is the ability to displace in the environment with ease and without restriction. In adults, mobility is an important factor in the loss of functional independence. Walking is basic in human motion and can be studied by assessing the gait cycle. This cycle is described from the moment one foot strikes the ground until the same foot returns to the ground. The body displaces in space for specific distance and the cycle repeats. Components of the gait cycle include stride, distance covered from one-foot strike to striking the ground again; distance covered by each foot and it is symmetric in length for both sides. The frequency of stepping is called cadence, and it is described as the number of steps per minute (Figure 1).
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Figure 1.
Gait phases.
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1.2 Gait and aging
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The neurophysiology of gait is a complex process that involves subcortical and cortical levels and executive aspects of attention and planning. Voluntary movements are always accompanied by postural control, which couples the programs that relate to the task with the adjustments of the movements and posture. The voluntary movement includes specific parts of the body, as well as adjustments of anticipation depending on the goal to be achieved. For the execution of the movements and the prediction of the postural programs, the cerebral cortex, the basal ganglia, the cerebellum, and the brainstem are used by descending systems that act on the spinal cord [6]. The signals from the basal ganglia and cerebellum control the excitability of the neurons in the cerebral cortex and brain stem by ascending and descending projections. All of these contributes to the planning, programming, and initiation of gait and, finally, modulates the rhythm and muscle tone during locomotion. It has been described that the loop formed by the basal ganglia, cerebellum, and the motor cortex can contribute to the purpose of the recalibration of the walking pattern to navigate in different environments [7]. The hierarchical organization of gait can also be described in several levels based on the classification of Hughlings Jackson [8]. The lower levels would be related to the cells of the anterior horns and the visual, vestibular, and proprioceptive system, which would be involved in the production of the force required for the balance and locomotion, as well as the sensory information, and would be associated with the orientation in the space in relation to the support surface. The middle level would modulate and refine the forces to stand, balance, and locomotion. Finally, the upper level would interpret and integrate the sensory input to select and organize the appropriate motor programs for the desired action [9].
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The decrease in gait can predict a mild cognitive impairment suggesting that motor changes may appear earlier than cognitive deficits [10]. Variables such as speed would be considered the most sensitive measure in the older population and could be a common and final expression of the decline that may occur with aging even when there are no clinically significant alterations or subjective complaints in relation to gait and mobility.
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Slowness in walking is associated with different factors, including risk factors such as high blood pressure (HBP), as well as changes in brain integrity age-related. Magnetic resonance (MR) studies in subjects without neurological disease have reported decreased volume in motor regions, the prefrontal cortex, the basal ganglia, and the medial temporal lobe. Among the structures described, the decrease in the right hippocampus, related to sensorimotor integration functions, as well as spatial memory, is strongly linked with cognitive deterioration profiles, as well as dementia. While speed could be considered useful in clinical screening, other studies indicate that it is also important to establish how gait parameters would be involved in aging since it has been reported that they could predict the risk of falls and loss in mobility affecting the quality of life [11]. The importance of these findings lies in the recognition of predictive factors that are easily accessible to clinicians who can detect early cognitive deterioration as well as dementia, which in turn will enable the creation of better strategies for planning, prevention, and treatment options [12].
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As described above, the gait is multidimensional, and it is a challenge with age because it requires mechanisms of automaticity and cognitive control to maintain performance under different conditions and to mitigate the effects of age. A model of five domains has been proposed to understand the complexities of gait: step, rhythm, asymmetry, variability, and postural control to evaluate gait in older adults. Due to this, each character has different neural mechanisms involved. Within these domains, the pace, variability, and postural control were more sensitive when age was used as a criterion to discriminate the walking pattern. This could be related to cognitive control and the impact of executive commitment rather than the rhythm which is associated with circuits of the brainstem and the spinal cord [13]. In addition, speed has been the most used to evaluate, discriminate, and predict measurements throughout the life course since it has strong clinimetric properties [14].
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Multiple factors contribute to maintaining the dynamics of gait; of these, the balance is considered a fundamental characteristic to achieve ambulation. Balance can be defined as the ability to control the body mass on a surface in order to maintain balance and orientation [15]. This process involves the integration of information from the nervous system, the sensory system, and the musculoskeletal system that allow the stabilization of the body mass during the activities of daily life [16]. The alteration of the balance in older adults is one of the most referred symptoms in the consultation, and when this is added to the gait alterations, they are considered predictors of falls [17]. It has been estimated that between 20 and 33% of adults over 65 experience balance problems; in addition to adults over 60, there is a 30% chance to fall at least in the first year, increasing by passing the 75 years [18].
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2. Defining pathological aging: concepts from human locomotion
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As previously described, gait depends on the integrity of the structures involved in both the planning—central nervous system—and the execution of motor tasks, peripheral nervous system and musculoskeletal system. While gait changes are common in older people, the presence of gait abnormalities suggests overt or covert pathologies [19]. Although some of these pathologies are easy to identify (e.g., sarcopenia), there are other conditions that represent a diagnostic challenge for the physician. This situation sometimes leads to the question: is this subject ill or just old? [20].
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To answer this question, some authors differentiate the normal aging from the non-normal aging using the term “pathological” or “secondary aging.” Secondary aging could be defined as an abnormal set of changes afflicting a segment rather than the entirety of the older population [21]. Trying to objectify the non-normal aging process and taking into account that many of these diseases affect the mobility and independence of the subjects, some authors have suggested that secondary aging could be assessed taking in to account the alterations in the gait pattern.
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The frequency of gait disorders increase with age; some reports suggest that prevalence rises from 10% between 60 and 69 years to 60% in subjects over 80 years [22]. Some of these pathological motor changes include:
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Reductions in gait speed: assessment of gait speed has been described as the sixth vital sign [23]; the preferred walking speed in older adults is a sensitive marker of general health and survival [24]. Although the decrease in speed could be considered normal during aging, some authors suggest that these reductions are associated with an incremented risk for developing mild cognitive impairment [25] and dementia [26, 27, 28]; also, gait slowness is related to bradykinesia considered one of the cardinal symptoms of Parkinson’s disease (PD).
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Reductions in stride length: reductions in stride length have been described in patients with PD [29, 30], subjects with small vessel disease [31], and osteoporotic women with recurrent falls [32].
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Increased gait variability: gait variability measures are unaltered in healthy older adults. Studies suggest that an increased gait variability could be associated with an increase of fall risk and could be a marker of pathological conditions such as PD, stroke, Alzheimer, and Huntington disease [33].
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Changes in arm swing: PD patients usually exhibit reduced arm swing magnitudes and a higher arm swing asymmetry even in early disease stages [33].
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2.1 From muscle to brain: diseases that lead to gait disorders in the elderly
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The abnormal conditions leading to pathological aging can be divided depending on the affected system; taking into account that some studies suggest that approximately two-thirds of those who had gait alterations also had neurological disorders, we present a three-level model adapted from the International Parkinson and Movement Disorder Society [19]:
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Lower-level disorders: this level includes pathologies that affect muscle, neuromuscular joint, or bones like extreme sarcopenia and osteopenia.
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Middle-level disorders: this level includes brain white matter, basal ganglia, and cerebellum disorders. Parkinson’s disease, Huntington disease, and cerebrovascular disease are included in this category.
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High-level disorders: also called frontal-subcortical gait disorder.
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2.2 Lower-level disorders
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Musculoskeletal gait disorders: osteoarthritis (inflammatory process involving bone) and lower limb skeletal deformities are the main non-neurological condition associated with non-normal gait changes in older adults [24]. Since most of these diseases affect articulations and mobility, they are usually assessed by measuring the range of motion (ROM) of the joint and its impact in gait speed. Some of the most common findings are summarized in Table 1.
Peripheral nerve gait disorders: peripheral neuropathy is a general term describing disease affecting the peripheral nerves. Prevalence of neuropathic complications of some chronic disease as diabetes increases with aging [34]. Although other neuropathies are rare in elderly [35], some findings are reported in these age groups (see Table 1).
Neuromuscular joint disorders: neuromuscular joint disorders as myasthenia gravis are more frequent in younger women; for that reason they are not discussed here.
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Level
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Anatomic localization
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Pathology leading to secondary aging
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Related motor changes
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Lower level
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Joints
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Foot and ankle inflammatory arthritis
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Decrease in walking speed, reduced cadence, increased double limb support, decreased step length, reduced sagittal plane ankle ROM [40]
Vascular, progressive supranuclear palsy (PSP), late Parkinson’s disease, normal pressure hydrocephalus
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Gait changes are not specific and are related to the pathology
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Table 1.
Gait disorders summary.
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2.3 Middle-level disorders
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Parkinson’s disease: PD is the second most common neurodegenerative disorder; its prevalence is dramatically increasing in older adults [36]. PD is characterized by a depletion of dopamine in the central nervous system leading to cardinal motor symptoms like bradykinesia (slowness of global motor tasks), tremor, postural instability, and rigidity. Objective changes in gait have been reported even in early PD stages and can be used to complement the diagnosis, follow up, and quantify the pharmacological response in these patients [33].
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Senile or late adult-onset chorea: chorea refers to a group of movement disorders characterized by the “dancing” appearance of the affected body parts. Although its diagnosis is rare in elderly subjects, there is small a group of patients who debut with symptoms at late ages [37]. To our knowledge, there are no gait analysis studies in patients with late-onset chorea; some of the alterations found in other types of chorea are shown in Table 1.
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Cerebrovascular disease: stroke is the second leading cause of death and a major cause of disability worldwide. Its incidence is increasing because of the population aging. Gait changes related to stroke depend on the location and extent of cerebral infarction. Given that hemiparesis is one of the most common motor features in the middle cerebral artery occlusion, most studies on gait analysis include hemiparetic patients [38]. See Table 1.
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Cerebellar disease: cerebellar disease could be related to age-dependent (multiple sclerosis) or aging-dependent (cerebellum atrophy, chronic alcohol consumption, stroke involving cerebellum) pathologies [39]. In our knowledge there is no a single study that evaluates gait changes in cerebellar pathology due to aging. Some of the motor features due to cerebellar disease are summarized in Table 1.
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2.4 High-level disorders
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Frontal-subcortical gait disorder: this syndrome includes disequilibrium unexplained by sensorimotor deficits, problems initiation or maintaining stepping (freezing of gait), and difficulty with foot placement. Gait changes are not specific.
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3. From medical to engineering consultation: importance of the objective gait assessment
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The clinical evaluation, within the medical consultation, of patients with movement disorders is usually subjective and has great intra- and inter-observer variability. This variability leads to difficulties in the diagnosis and the follow-up of patients. With the development of new technologies, the objective gait analysis has been more used in the research context. These technological devices allow to detect subtle motor changes even in early stages of the disease, usually when the physician cannot identify them using regular observation (naked eye). In the next sections, we will address the relevance of the objective gait analysis and the importance of precision medicine in the future of the diagnostic, follow-up, and decision-making processes of patients with neurologic and non-neurologic diseases.
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4. Ecological assessment
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Studies on the human body and phenomena that affect its functioning, such as diseases or aging, have an experimental design in which individuals are subjected to various tests for data collection.
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Currently, clinical tests that consist of physical tests such as gait assessment are based on electronic measurement instruments, such as wearables, as seen in the previous section, which seeks to establish objective measures. However, to ensure the quality of the measurements, not only precision is required. Clinical tests may have the Hawthorne effect, which is not desirable.
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This effect is that the people under study change their behavior because they are being observed. In the case of gait analysis, this implies that individuals alter their way of walking [47, 48]. In fact, Berthelot et al. [49] affirm that this effect should be taken into account during the clinical tests since they showed different results if they were tested blindly and found advantages in blind conditions for gait speed (GS) and timed up and go (TUG) tests.
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The study by Robles-García et al. [50] has explored the impact of the effect on the gait analysis, evaluating 30 people, 15 with Parkinson’s disease (PD) and 15 healthy people, 8 of whom were young and 7 elderlies. Gait variables such as cadence and gait speed were measured. The test consisted of walking distance of 17 m with people being aware of being measured and then being told to return to the starting position having to walk the same distance but not being aware that they were also being measured back. They found significant differences in the overt and covert measurement, observing that the gait speed decreases and the cadence increases when they are aware of being measured. They conclude that there is Hawthorne effect in gait evaluation and assert that this is because people seek to perform well when they are evaluated.
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In addition, Malchow and Fiedler [51] in another study performed a gait analysis in people with lower limb prostheses, in which the objective was to see if the observer affects the results of the experiments. For this, they used some lies in individuals to measure them without feeling that they were observed and the measurements were compared with a formal evaluation. The results allowed to conclude that the effect of the observation exists in the analysis of prosthetic walking because, in the presence of observers, people under study presented changes of their walking pattern in gait speed, stride length, and stride symmetry.
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Therefore, it is sought that the collected data have ecological validity, which means that the environment of the experiment, its methods, and materials should approximate the real world [52, 53]. This implies that by guaranteeing ecological validity, the Hawthorne effect is avoided [54]. Thus, ecological assessments are important in determining measurements that have ecological validity.
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Wearables, for example, are an approach to ecological assessment, but it is not the only one. Other studies have proposed the use of a markerless system based on depth cameras and ambience devices defined as the use of multiple installed sensors to collect data related individuals in close proximity to them [55].
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For example, the study by Auvinet et al. [56] presents a new way to reconstruct the 3D model of a human body from 3 low-cost depth cameras that can recover a body shape in a 3D space in real time that was more accurate than 20 normal cameras.
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In addition, in the study by Muñoz et al. [33] that with a device based on Microsoft Kinect is able to sense the movement of each body part of the individual. The motion information of 25 joints is obtained by skeleton tracking provided by Kinect.
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Finally, an example of ambience devices is an intelligent carpet developed by Cantoral-Ceballos et al. [57] using plastic optical fiber (POF) that sense bending, quantified by measuring light transmission. The carpet is able to follow real-time the human footprint which allows calculating spatial-temporal variables of gait.
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All previous studies would allow a covert assessment because the systems are portable, mountable in a day-to-day scenario, and no need to use markers or something in particular, but simply by being close to the sensors, which implies that the patients would not require knowing that they are being examined.
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Considering that ecological validity allows to obtain reliable results, there are methods that allow maximizing the ecological validity of the clinical tests of gait, which can be improved using a test that implies a double task, in which the person must do a concurrent cognitive task or motor while doing the walk test because the situation resembles real-life actions [52, 58].
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An example of this strategy is the study by Wang et al. [59] where it was tried to simulate daily activities to know if the use of a circuit of cameras in the home for the continuous care to the elderly is feasible. The experiment consisted in that patients should move in a scenario that looks like a house, doing daily tasks such as opening the door, sitting on the sofa or stand up, and looking for objects and compare the gait variables extracted from the experiment with clinical assessments. The variables that were measured were gait speed, step length, and step time and were measured during the lapses in which the people are walking in the scenario. The researchers found that there are significant differences in gait parameters between continuous onstage monitoring and clinical trials, which led them to conclude that the clinical trials show Hawthorne effect.
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Taking into consideration that ecological validity is important for the evaluation of the gait, in-home survey systems have been developed to monitor and analyze the walking of residents, especially focused on elderly care, sensing people with physiological and pathological aging. The main objective of these survey systems is to prevent and alert falls through algorithms of gait analysis in everyday life, detecting anomalies in the progress of daily activity due to falls; fall-induced injuries are the fifth leading cause of death in older adults [60].
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For example, the study by Stone et al. [61] presents a system consisting of a Microsoft Kinect used in depth camera mode, deployed in an assisted living residence for continuous gait analysis. The system allows to measure gait variables continuously to report changes in the resident progress, make fall risk assessments, and detect early anomalies. The system serves to support the tasks of the nurses inside the residence, who can see the reports generated by the system.
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5. Future of gait analysis in aging
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According to the HealthAge International report, in the year 2015, there were 901 million people aged 60 years or over; by the year 2030, the number will grow to 1.4 billion; and by 2050, reaching nearly 2.1 billion. The “oldest-old” group, people aged 80 years or over, is growing even faster than the number of older persons overall; this represents at least 202 million people in 2030 and approximately 434 million for 2050 [62, 63]. This generates a high interest in researching and developing improvements in current systems that can support and improve the quality of life of the future world population.
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As previously mentioned, gait analysis is a process by which a clinical expert performs an objective evaluation of the walk, measuring and generating spatiotemporal variables associated with movements of the lower and upper extremities, posture, and balance. Aging (pathological and physiological) generates changes in the walking pattern, affecting the older population. With the current gait analysis, these conditions can be quantified and obtained, through these variables.
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According to the current literature, the main devices to perform this analysis are the gait laboratories (GaitRite or Vicon). Moreover, with the recent technological developments, new devices focused on gait analysis have been developed, such as handles with accelerometers, tracking systems of joints or body segments using cameras, smart templates and force platforms.
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In addition to this, with the rise of concepts and technologies such as Internet of things, data science, artificial intelligence, and smart cities and homes, among others, recent developments have focused on contributing to the older population. Such is the case of Roschelle et al. [64], who trained intelligent algorithms through five different sensors (infrared motion, light, humidity, contact, and temperature) and supervision of nurses through telehealth strategies and periodic visits to the smart home for medical assistance (health-assistive smart homes) [64]. This work focuses on assessing the challenges and opportunities generated by information-gathering strategies nurse driven for data analytics. In conclusion, they affirmed that the training of algorithms led by nurses can contribute with tools that allow to monitor and alert about the abnormal state of a group of patients, such as reduction in average activity, slower walk, and increase in the use of bathrooms, without generating daily annoyances or obstructions, since for reasons of privacy, many older adults prefer not to be recorded, with a camera or microphone [64].
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Another example is documented by Yacchirema et al., who proposed a system for detection of falls using IoT and machine learning algorithms; this system uses three-axis accelerometers, embedded in a wearable 6LowPan device able to capture in real time the information associated with the movements of the volunteers [65]. However, not only the development of intelligent solutions and low obstruction is enough, it is also necessary to promote the integration of these solutions with the ambient assisted living environment and the work environments of the current aging population [66, 67].
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In recent years, the term smart aging was developed, which focuses on promoting care and good aging of the adult population, through ICT technologies, i.e., medical systems and devices, biotechnology, and robotics [62]. This new term will encourage the development of solutions through robotic assistance, such as [68] who proposed a system of rehabilitation of walking supported by a robotic structure (MOPASS), which was tested in patients with 60 or more years, during 5 therapies. The results showed moderate usability and good acceptability. However, a large sample size is necessary to validate and generalize the results obtained [68].
\n
These automated gait analysis systems not only focus on healthy people, many of the systems and current developments contribute to the measurement and diagnosis of patients with different neurodegenerative conditions, such as Parkinson’s and Alzheimer’s. In the case of Parkinson, Terashima and Saegusa developed a robot-assisted gait training device to support walking rehabilitation for older patients. This device not only focuses on the motor part of the patient, it also contributes to cognitive rehabilitation. The device was evaluated with a Parkinson’s patient with episodes of freezing of gait, and the stimuli generated by Lucia, an assistant robot, were effective in breaking freezing. In addition to this, the inclusion of assistant robots allows the clinical expert to focus on the patient’s body and gait observation.
\n
Considering the current context of gait analysis, and the recent technological developments focused on wearable and non-obtrusive technologies, the future of gait analysis could focus on the ecological and precise evaluations that allow aging in-place on smart cities or smart homes [69]. This can be obtained through IoT evaluation systems, invisible to the patient, connected with alert and security systems, and that allow diagnosis and decision-making using artificial intelligence algorithms.
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6. Conclusions
\n
In this chapter, we have revised not only the normal aging and pathological aging process but also the technical evolution of wearable devices and affordable devices that has been developed for gait analysis, helping physicians and experts in the diagnosis of different conditions which affect gait.
\n
\n
Acknowledgments
\n
This work was possible thanks to Colciencias Grant #845-2017 and internal support form Universidad Icesi and Valle del Lili Clinical.
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Conflict of interest
Authors certify that they have NO affiliations with involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements) or nonfinancial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter discussed in this manuscript.
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We analyze different approaches used for gait analysis using wearables and affordable devices like inertial units (IMU), accelerometers, and depth cameras like Microsoft Kinect or Intel’s RealSense, which have been available at least in an academic context but will be available for daily use in the near future.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/66260",risUrl:"/chapter/ris/66260",signatures:"Beatriz Muñoz, Jaime Valderrama, Jorge Orozco, Yor Castaño, Linda Montilla, Domiciano Rincon and Andres Navarro",book:{id:"7952",type:"book",title:"Smart Healthcare",subtitle:null,fullTitle:"Smart Healthcare",slug:"smart-healthcare",publishedDate:"February 5th 2020",bookSignature:"Thomas F. Heston",coverURL:"https://cdn.intechopen.com/books/images_new/7952.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-78984-352-1",printIsbn:"978-1-78984-351-4",pdfIsbn:"978-1-83880-135-9",isAvailableForWebshopOrdering:!0,editors:[{id:"217926",title:"Dr.",name:"Thomas F.",middleName:null,surname:"Heston",slug:"thomas-f.-heston",fullName:"Thomas F. 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Aging",level:"1"},{id:"sec_1_2",title:"1.1 Characteristics of aging",level:"2"},{id:"sec_2_2",title:"1.2 Gait and aging",level:"2"},{id:"sec_4",title:"2. Defining pathological aging: concepts from human locomotion",level:"1"},{id:"sec_4_2",title:"2.1 From muscle to brain: diseases that lead to gait disorders in the elderly",level:"2"},{id:"sec_5_2",title:"2.2 Lower-level disorders",level:"2"},{id:"sec_6_2",title:"2.3 Middle-level disorders",level:"2"},{id:"sec_7_2",title:"2.4 High-level disorders",level:"2"},{id:"sec_9",title:"3. From medical to engineering consultation: importance of the objective gait assessment",level:"1"},{id:"sec_10",title:"4. Ecological assessment",level:"1"},{id:"sec_11",title:"5. Future of gait analysis in aging",level:"1"},{id:"sec_12",title:"6. Conclusions",level:"1"},{id:"sec_13",title:"Acknowledgments",level:"1"},{id:"sec_16",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Fukuoka H, Afshari NA. 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Being surveyed can change later behavior and related parameter estimates. Proceedings of the National Academy of Sciences. 2011;108(5):1821-1826\n'},{id:"B49",body:'Berthelot J-M, Le Goff B, Maugars Y. The Hawthorne effect: Stronger than the placebo effect? Joint, Bone, Spine : Revue Du Rhumatisme. 2011;78(4):335-336\n'},{id:"B50",body:'Robles-García V et al. Spatiotemporal gait patterns during overt and covert evaluation in patients with Parkinson’s disease and healthy subjects: Is there a Hawthorne effect? Journal of Applied Biomechanics. 2015;31(3):189-194\n'},{id:"B51",body:'Malchow C, Fiedler G. Effect of observation on lower limb prosthesis gait biomechanics: Preliminary results. Prosthetics and Orthotics International. 2015;40(6):739-743\n'},{id:"B52",body:'Moseley AM et al. Ecological validity of walking speed assessment after traumatic brain injury: A pilot study. The Journal of Head Trauma Rehabilitation. 2004;19(4)\n'},{id:"B53",body:'Lee H, Sullivan SJ, Schneiders AG. The use of the dual-task paradigm in detecting gait performance deficits following a sports-related concussion: A systematic review and meta-analysis. Journal of Science and Medicine in Sport. 2013;16(1):2-7\n'},{id:"B54",body:'Ferguson L. External validity, generalizability, and knowledge utilization. Journal of Nursing Scholarship. 2004;36(1):16-22\n'},{id:"B55",body:'Yu X. Approaches and principles of fall detection for elderly and patient. In: HealthCom-10th International Conference on e-Health Networking, Applications and Services. 2008. pp. 42-47\n'},{id:"B56",body:'Auvinet E, Meunier J, Multon F. Multiple depth cameras calibration and body volume reconstruction for gait analysis. In: 11th International Conference on Information Science, Signal Processing and their Applications (ISSPA). 2012. pp. 478-483\n'},{id:"B57",body:'Cantoral-Ceballos JA et al. Intelligent carpet system, based on photonic guided-path tomography, for gait and balance monitoring in home environments. IEEE Sensors Journal. 2015;15(1):279-289\n'},{id:"B58",body:'Ebersbach G, Dimitrijevic MR, Poewe W. Influence of concurrent tasks on gait: A dual-task approach. Perceptual and Motor Skills. 1995;81(1):107-113\n'},{id:"B59",body:'Wang F, Stone E, Skubic M, Keller JM, Abbott C, Rantz M. Toward a passive low-cost in-home gait assessment system for older adults. IEEE Journal of Biomedical and Health Informatics. 2013;17(2):346-355\n'},{id:"B60",body:'Kannus P, Parkkari J, Niemi S, Palvanen M. Fall-induced deaths among elderly people. American Journal of Public Health. 2005;95(3):422-424\n'},{id:"B61",body:'Stone EE, Skubic M. Unobtrusive, continuous, in-home gait measurement using the Microsoft Kinect. IEEE Transactions on Biomedical Engineering. 2013;60(10):2925-2932\n'},{id:"B62",body:'Song I-Y, Song M, Timakum T, Ryu S-R, Lee H. The landscape of smart aging: Topics, applications, and agenda. Data & Knowledge Engineering. 2018;115:68-79\n'},{id:"B63",body:'Global Age Watch Index. The Global Age Watch Index Ranks Countries By How Well Their Older Populations Are Faring. 2015. Available from: helpage.org\n\n'},{id:"B64",body:'Fritz RL, Dermody G. A nurse-driven method for developing artificial intelligence in “smart” homes for aging-in-place. Nursing Outlook. 2018. DOI:10.1016/j.outlook.2018.11.004\n'},{id:"B65",body:'Yacchirema D, de Puga JS, Palau C, Esteve M. Fall detection system for elderly people using IoT and ensemble machine learning algorithm. Personal and Ubiquitous Computing. 2019. DOI:10.1007/s00779-018-01196-8\n'},{id:"B66",body:'Rahman MA, Hossain MS. A cloud-based virtual caregiver for elderly people in a cyber physical IoT system. Cluster Computing. 2018. DOI:10.1007/s10586-018-1806-y\n'},{id:"B67",body:'Skouby KE, Kivimäki A, Haukiputo L, Lynggaard P, Windekilde IM. Smart cities and the ageing population. In: The 32nd Meeting of WWRF. 2014\n'},{id:"B68",body:'Haesner M, Spranger M, Kuzmicheva O, Gräser A, Steinhagen-Thiessen E. Usability and acceptability by a younger and older user group regarding a mobile robot-supported gait rehabilitation system. Assistive Technology: The Official Journal of RESNA. 2019;31(1):25-33\n'},{id:"B69",body:'Maus M, Lindeman DA, Satariano WA. Wayfinding, mobility, and technology for an aging society. In: Hunter RH, Anderson LA, Belza BL, editors. Community Wayfinding: Pathways to Understanding. Cham: Springer International Publishing; 2016. pp. 153-167\n'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Beatriz Muñoz",address:null,affiliation:'
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Experiments were carried out under simulated conditions typical for the operation of plasma facing in-vessel mirrors of optical plasma diagnostics in fusion reactor ITER. Bombardment with D0 and T0 atoms radiated from burning plasma was predicted to be the main reason for the degradation of optical properties of such mirrors. Therefore, to simulate the behavior of mirrors in ITER, mirror-like samples were subjected to bombardment by ions of deuterium plasma with fixed or wide energy distribution. The effects of ion bombardment on optical properties, development of roughness, uptake of deuterium, appearance of blisters, and manifestation of some chemical processes are presented and discussed.",signatures:"Vladimir S. Voitsenya, Alexandra F. Bardamid, Martin Balden, Flaviu Gostin, Sergey V. Khovrich, Vladimir G. Konovalov, Konstantin V. Kovtun, Petro M. Lytvyn, Sergey V. Ketov, Dmitri V. Luzguine-Luzgin, Sergei I. Solodovchenko, Anatoly N. Shapoval, Anatoly F. Shtan’, Vladislav N. 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He is a specialist in Expt. Condensed Matter Physics/Materials Science with a Ph.D. from the Institute of Science, Banaras Hindu University (B.H.U), Varanasi, India; a post-doctorate degree from Stockholm University, Sweden and then work experience as a DST Inspire Faculty at Panjab University, Chandigarh. He has contributed over 37 peer-reviewed international research publications and authored four book chapters, two book articles and one book. His research work has been selected for talks and discussions in several premier international and national conferences. He has mentored graduate, postgraduate and PhD students. He has been the recipient of several prestigious international/national fellowships and awards such as the Seal of Excellence from European Commission, DST Inspire Faculty Award, Postdoctoral Fellowship etc. He has strong research professional skills in nanomaterials, alloys, structure-property correlations, electron microscopy and metal physics.",institutionString:"Amity School of Applied Sciences, Amity University",institution:{name:"Amity University",institutionURL:null,country:{name:"India"}}},{id:"184181",title:"Prof.",name:"R.S.",surname:"Tiwari",slug:"r.s.-tiwari",fullName:"R.S. Tiwari",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"184182",title:"Prof.",name:"O.N.",surname:"Srivastava",slug:"o.n.-srivastava",fullName:"O.N. 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The Open Access model is applied to all of our publications and is designed to eliminate subscriptions and pay-per-view fees. This approach ensures free, immediate access to full text versions of your research.
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Dissemination and Promotion
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The Open Access Publishing Fee (OAPF) is payable only after your book chapter, monograph or journal article is accepted for publication.
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OAPF Publishing Options
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1,400 GBP Chapter - Edited Volume
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850 GBP Chapter - Book Series Topic (Annual Volume)
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10,000 GBP Monograph - Long Form
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4,000 GBP Compacts Monograph - Short Form
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850 GBP Journal Article (Across Portfolio)
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During the launching phase journals do not charge an APC, rather they will be funded by IntechOpen.
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*These prices do not include Value-Added Tax (VAT). Residents of European Union countries need to add VAT based on the specific rate in their country of residence. Institutions and companies registered as VAT taxable entities in their own EU member state will not pay VAT as long as provision of the VAT registration number is made during the application process. This is made possible by the EU reverse charge method.
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Services included are:
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An online manuscript tracking system to facilitate your work
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Personal contact and support throughout the publishing process from your dedicated Author Service Manager
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English language copyediting and proofreading, including the correction of grammatical, spelling, and other common errors
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XML Typesetting and pagination - web (PDF, HTML) and print files preparation
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Discoverability - electronic citation and linking via DOI
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Permanent and unrestricted online access to your work
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What isn't covered by the Open Access Publishing Fee?
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If your manuscript:
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If a manuscript requires Heavy Editing or Language Polishing, this will incur additional fees.
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Your Author Service Manager will inform you of any items not covered by the OAPF and provide exact information regarding those additional costs before proceeding.
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Open Access Funding
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To explore funding opportunities and learn more about how you can finance your IntechOpen publication, go to our Open Access Funding page. IntechOpen offers expert assistance to all of its Authors. We can support you in approaching funding bodies and institutions in relation to publishing fees by providing information about compliance with the Open Access policies of your funder or institution. We can also assist with communicating the benefits of Open Access in order to support and strengthen your funding request and provide personal guidance through your application process. You can contact us at funders@intechopen.com for further details or assistance.
\n\n
For Authors who are still unable to obtain funding from their institutions or research funding bodies for individual projects, IntechOpen does offer the possibility of applying for a Waiver to offset some or all processing feed. Details regarding our Waiver Policy can be found here.
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Added Value of Publishing with IntechOpen
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Choosing to publish with IntechOpen ensures the following benefits:
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Indexing and listing across major repositories, see details ...
\n\t
Long-term archiving
\n\t
Visibility on the world's strongest OA platform
\n\t
Live Performance Metrics to track readership and the impact of your chapter
\n\t
Dissemination and Promotion
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Benefits of Publishing with IntechOpen
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Proven world leader in Open Access book publishing with over 10 years experience
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+5,700 OA books published
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Most competitive prices in the market
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Fully compliant with OA funding requirements
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Optimized processes that assure your research is made available to the scientific community without delay
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Personal support during every step of the publication process
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+184,650 citations in Web of Science databases
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Currently strongest OA platform with over 175 million downloads
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. 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From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. 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Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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They show broad diversity of mineral associations, with Vesuvius and Vulcano being also among the world localities richest in mineral species. Volcanic systems, which show recession over a longer period, show fumarolic development from the high-temperature alkaline halide/sulphate, calcic sulphate or sulphidic parageneses, synchronous with or immediately following the eruptions, through medium-temperature ammonium minerals, metal chlorides, or fluoride associations to the late low-temperature paragenesis dominated by sulphur, gypsum, alunogen, and other hydrous sulphates. The situation can be different in the systems that are not recessing but show fluctuations in activity, illustrated by the example of Vulcano where the high-temperature association appears intermittently. A full survey of the mineral groups and species is given in respect to their importance and appearance in fumarolic associations.",book:{id:"5311",slug:"updates-in-volcanology-from-volcano-modelling-to-volcano-geology",title:"Updates in Volcanology",fullTitle:"Updates in Volcanology - From Volcano Modelling to Volcano Geology"},signatures:"Tonči Balić-Žunić, Anna Garavelli, Sveinn Peter Jakobsson, Kristjan\nJonasson, Athanasios Katerinopoulos, Konstantinos Kyriakopoulos\nand Pasquale Acquafredda",authors:[{id:"183593",title:"Dr.",name:"Tonci",middleName:null,surname:"Balic-Zunic",slug:"tonci-balic-zunic",fullName:"Tonci Balic-Zunic"},{id:"183700",title:"Prof.",name:"Anna",middleName:null,surname:"Garavelli",slug:"anna-garavelli",fullName:"Anna Garavelli"},{id:"183701",title:"Dr.",name:"Sveinn Peter",middleName:null,surname:"Jakobsson",slug:"sveinn-peter-jakobsson",fullName:"Sveinn Peter Jakobsson"},{id:"183702",title:"Prof.",name:"Athanasios",middleName:null,surname:"Katerinopoulos",slug:"athanasios-katerinopoulos",fullName:"Athanasios Katerinopoulos"},{id:"188833",title:"Dr.",name:"Kristjan",middleName:null,surname:"Jonasson",slug:"kristjan-jonasson",fullName:"Kristjan Jonasson"},{id:"188834",title:"Dr.",name:"Konstantinos",middleName:null,surname:"Kyriakopoulos",slug:"konstantinos-kyriakopoulos",fullName:"Konstantinos Kyriakopoulos"},{id:"188835",title:"Dr.",name:"Pasquale",middleName:null,surname:"Acquafredda",slug:"pasquale-acquafredda",fullName:"Pasquale Acquafredda"}]},{id:"51105",doi:"10.5772/63486",title:"How Polygenetic are Monogenetic Volcanoes: Case Studies of Some Complex Maar‐Diatreme Volcanoes",slug:"how-polygenetic-are-monogenetic-volcanoes-case-studies-of-some-complex-maar-diatreme-volcanoes",totalDownloads:1939,totalCrossrefCites:5,totalDimensionsCites:15,abstract:"The increasing number of field investigations and various controlled benchtop and large‐scale experiments have permitted the evaluation of a large number of processes involved in the formation of maar‐diatreme volcanoes, the second most common type of small‐volume subaerial volcanoes on Earth. A maar‐diatreme volcano is recognized by a volcanic crater that is cut into country rocks and surrounded by a low‐height ejecta rim composed of pyroclastic deposits of few meters to up to 200 m thick above the syn‐eruptive surface level. The craters vary from 0.1 km to up to 5 km wide and vary in depth from a few dozen meters to up to 300 m deep. Their irregular morphology reflects the simple or complex volcanic and cratering processes involved in their formation. The simplicity or complexity of the crater or the entire maar itself is usually observed in the stratigraphy of the surrounding ejecta rings. The latter are composed of sequences of successive alternating and contrastingly bedded phreatomagmatic‐derived dilute pyroclastic density currents (PDC) and fallout depositions, with occasional interbedded Strombolian‐derived spatter materials or scoria fall units, exemplifying the changes in the eruptive styles during the formation of the volcano. The entire stratigraphic sequence might be preserved as a single eruptive package (small or very thick) in which there is no stratigraphic gap or significant discordance indicative of a potential break during the eruption. A maar with a single eruptive deposit is quantified as monogenetic maar, meaning that it was formed by a single eruptive vent from which only a small and ephemeral magma erupted over a short period of time. The stratigraphy may also display several packages of deposits separated either by contrasting discordance surfaces or paleosoils, which reflect multiple phases or episodes of eruptions within the same maar. Such maars are characterized as complex polycyclic maars if the length of time between the eruptive events is relatively short (days to years). For greater length of time (thousands to millions of years), the complex maar will be quantified as polygenetic. These common depositional breaks interpreted as signs of temporal interruption of the eruptions for various timescales also indicate deep magma system processes; hence magmas of different types might erupt during the formation of both simple and complex maars. The feeding dikes can interact with groundwater and form closely distributed small craters. The latter can coalesce to form a final crater with various shapes depending on the distance between them. This observation indicates the significant role of the magmatic plumbing system on the formation and growth of complex and polygenetic maar‐diatreme volcanoes.",book:{id:"5311",slug:"updates-in-volcanology-from-volcano-modelling-to-volcano-geology",title:"Updates in Volcanology",fullTitle:"Updates in Volcanology - From Volcano Modelling to Volcano Geology"},signatures:"Boris Chako Tchamabé, Gabor Kereszturi, Karoly Németh and\nGerardo Carrasco‐Núñez",authors:[{id:"51162",title:"Dr.",name:"Károly",middleName:null,surname:"Németh",slug:"karoly-nemeth",fullName:"Károly Németh"},{id:"62029",title:"Dr.",name:"Gabor",middleName:null,surname:"Kereszturi",slug:"gabor-kereszturi",fullName:"Gabor Kereszturi"},{id:"182834",title:"Dr.",name:"Boris",middleName:null,surname:"Chako Tchamabé",slug:"boris-chako-tchamabe",fullName:"Boris Chako Tchamabé"},{id:"183809",title:"Dr.",name:"Gerardo",middleName:null,surname:"Carrasco-Núñez",slug:"gerardo-carrasco-nunez",fullName:"Gerardo Carrasco-Núñez"}]},{id:"49656",doi:"10.5772/61974",title:"Optical Satellite Remote Sensing of the Coastal Zone Environment — An Overview",slug:"optical-satellite-remote-sensing-of-the-coastal-zone-environment-an-overview",totalDownloads:2463,totalCrossrefCites:7,totalDimensionsCites:15,abstract:"Optical remote-sensing data are a powerful source of information for monitoring the coastal environment. Due to the high complexity of coastal environments, where different natural and anthropogenic phenomenon interact, the selection of the most appropriate sensor(s) is related to the applications required, and the different types of resolutions available (spatial, spectral, radiometric, and temporal) need to be considered. The development of specific techniques and tools based on the processing of optical satellite images makes possible the production of information useful for coastal environment management, without any destructive impacts. This chapter will highlight different subjects related to coastal environments: shoreline change detection, ocean color, water quality, river plumes, coral reef, alga bloom, bathymetry, wetland mapping, and coastal hazards/vulnerability. The main objective of this chapter is not an exhaustive description of the image processing methods/algorithms employed in coastal environmental studies, but focus in the range of applications available. Several limitations were identified. The major challenge still is to have remote-sensing techniques adopted as a routine tool in assessment of change in the coastal zone. Continuing research is required into the techniques employed for assessing change in the coastal environment.",book:{id:"5104",slug:"environmental-applications-of-remote-sensing",title:"Environmental Applications of Remote Sensing",fullTitle:"Environmental Applications of Remote Sensing"},signatures:"Ana C. Teodoro",authors:[{id:"18485",title:"Dr.",name:"Ana",middleName:null,surname:"Teodoro",slug:"ana-teodoro",fullName:"Ana Teodoro"}]},{id:"49851",doi:"10.5772/62122",title:"Detection of Tree Crowns in Very High Spatial Resolution Images",slug:"detection-of-tree-crowns-in-very-high-spatial-resolution-images",totalDownloads:3240,totalCrossrefCites:8,totalDimensionsCites:13,abstract:"The requirements for advanced knowledge on forest resources have led researchers to develop efficient methods to provide detailed information about trees. Since 1999, orbital remote sensing has been providing very high resolution (VHR) image data. The new generation of satellite allows individual tree crowns to be visually identifiable. The increase in spatial resolution has also had a profound effect in image processing techniques and has motivated the development of new object-based procedures to extract information. Tree crown detection has become a major area of research in image analysis considering the complex nature of trees in an uncontrolled environment. This chapter is subdivided into two parts. Part I offers an overview of the state of the art in computer detection of individual tree crowns in VHR images. Part II presents a new hybrid approach developed by the authors that integrates geometrical-optical modeling (GOM), marked point processes (MPP), and template matching (TM) to individually detect tree crowns in VHR images. The method is presented for two different applications: isolated tree detection in an urban environment and automatic tree counting in orchards with an average performance rate of 82% for tree detection and above 90% for tree counting in orchards.",book:{id:"5104",slug:"environmental-applications-of-remote-sensing",title:"Environmental Applications of Remote Sensing",fullTitle:"Environmental Applications of Remote Sensing"},signatures:"Marilia Ferreira Gomes and Philippe Maillard",authors:[{id:"177110",title:"Dr.",name:"Philippe",middleName:null,surname:"Maillard",slug:"philippe-maillard",fullName:"Philippe Maillard"},{id:"177172",title:"Ph.D.",name:"Marilia",middleName:"Ferreira",surname:"Gomes",slug:"marilia-gomes",fullName:"Marilia Gomes"}]}],mostDownloadedChaptersLast30Days:[{id:"66703",title:"P-Wave Teleseismic Tomography: Evidence of Imprints of Deccan Mantle Plume below the Kachchh Rift Zone, Gujarat, India",slug:"p-wave-teleseismic-tomography-evidence-of-imprints-of-deccan-mantle-plume-below-the-kachchh-rift-zon",totalDownloads:2602,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"The Indian plate had experienced the Deccan volcanism at 65 Ma when it moved over the Re-union hotspot, which has altered lithospheric structure below the Kachchh rift zone (KRZ). To quantify the influence of Deccan volcanism on the crust-mantle, the present chapter focuses on the delineation of the upper mantle structure below the KRZ, through the modeling of crust corrected P-residuals and P-wave teleseismic tomography. The crust corrected normalized P-residuals suggest dominant negative residuals associated with the central KRZ, indicating crustal and lithospheric thinning below the KRZ. A low velocity down to a depth of 170 km below the central KRZ is detected through the teleseismic tomography using these P-residuals. However, these residuals also show positive values for the surrounding un-rifted zones. Note that a low shear velocity zone extending from 100–120 km to 170–220 km depth beneath the central KRZ has already been revealed by the modeling of P-RFs. This reduction in seismic velocity in the upper mantle could be explained by the presence of trapped carbonatite/partial melts related to the Deccan volcanism. The influx of volatile CO2 emanating from the carbonatite melts in the asthenosphere might be generating lower crustal earthquakes occurring in the KRZ.",book:{id:"7677",slug:"forecasting-volcanic-eruptions",title:"Forecasting Volcanic Eruptions",fullTitle:"Forecasting Volcanic Eruptions"},signatures:"Prantik Mandal",authors:[{id:"279344",title:"Dr.",name:"Prantik",middleName:null,surname:"Mandal",slug:"prantik-mandal",fullName:"Prantik Mandal"}]},{id:"49608",title:"Remote Sensing of Mountain Glaciers and Related Hazards",slug:"remote-sensing-of-mountain-glaciers-and-related-hazards",totalDownloads:2386,totalCrossrefCites:1,totalDimensionsCites:5,abstract:"Mountain glaciers are highly sensitive to temperature and precipitation fluctuations and active geomorphic agents in shaping the landforms of glaciated regions which are direct imprints of past glaciations, providing reliable evidence of the evolution of the past Cryosphere and contain important information on climatic variables. But most importantly, glaciers have aroused a lot of concern in terms of glacier area changes, thickness change, mass balance and their consequences on water resources as well as related hazards. The contribution of glacier mass loss to global sea-level rise and increasing number of glacier-related hazards are the most important and current socioeconomic concerns. Therefore, understanding the dynamics of the changes and constant monitoring of glaciers are essential for studying climate, water resource management and hydropower and also to predict and evade glacier-related hazards. The recent advances in the techniques of earth observations have proved as a boon for investigating glaciers and glacier-related hazards. Remote sensing technology enables extraction of glacier parameters such as albedo/reflectance/scattering, glacier area, glacier zones and facies, equilibrium line, glacier thickness, volume, mass balance, velocity and glacier topography. The present chapter explores the prospective of remote sensing technology for understanding and surveying glaciers formed at high, inaccessible mountains and glacier-induced hazards.",book:{id:"5104",slug:"environmental-applications-of-remote-sensing",title:"Environmental Applications of Remote Sensing",fullTitle:"Environmental Applications of Remote Sensing"},signatures:"Pratima Pandey, Alagappan Ramanathan and Gopalan\nVenkataraman",authors:[{id:"18342",title:"Prof.",name:"Ramanathan",middleName:null,surname:"Alagappan",slug:"ramanathan-alagappan",fullName:"Ramanathan Alagappan"},{id:"177179",title:"Dr.",name:"Pratima",middleName:null,surname:"Pandey",slug:"pratima-pandey",fullName:"Pratima Pandey"},{id:"178231",title:"Prof.",name:"Gopalan",middleName:null,surname:"Venkataraman",slug:"gopalan-venkataraman",fullName:"Gopalan Venkataraman"}]},{id:"60548",title:"Volcanic Glass and its Uses as Adsorbent",slug:"volcanic-glass-and-its-uses-as-adsorbent",totalDownloads:1601,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"Volcanic glasses are an amorphous phyllosilicates formed by the fast cooling of the magma. The physicochemical properties of volcanic glasses are directly related to their chemical composition. Thus, the rhyolitic magma, which presents the highest SiO2 percentage, displays a high viscosity, which leads to explosive eruptions by the ex-solution of H2O, CO2, and SO2, when the pressure diminishes generates a macroporous structure with interesting applications in construction, as abrasive, acoustic, filter as well as in the agriculture field. The macroporosity of volcanic glass allows to host large molecules as biomolecules, tensoactives, or dyes. On the other hand, the existence of hydroxyl groups in this amorphous aluminosilicate also favors the adsorption of cations and anions, so the volcanic glass is an economical adsorbent to retain heavy metals or radioactive cations.",book:{id:"6104",slug:"volcanoes-geological-and-geophysical-setting-theoretical-aspects-and-numerical-modeling-applications-to-industry-and-their-impact-on-the-human-health",title:"Volcanoes",fullTitle:"Volcanoes - Geological and Geophysical Setting, Theoretical Aspects and Numerical Modeling, Applications to Industry and Their Impact on the Human Health"},signatures:"Juan Antonio Cecilia, Miguel Armando Autie-Pérez, Juan Manuel\nLabadie-Suarez, Enrique Rodríguez Castellón and Antonia Infantes\nMolina",authors:[{id:"126325",title:"Dr.",name:"Enrique",middleName:null,surname:"Rodríguez-Castellón",slug:"enrique-rodriguez-castellon",fullName:"Enrique Rodríguez-Castellón"}]},{id:"57502",title:"The Characteristics of Volcanic Eruption in Indonesia",slug:"the-characteristics-of-volcanic-eruption-in-indonesia",totalDownloads:1846,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"This chapter discusses the unique characteristics of the volcanic eruptions in Indonesia. We know that Indonesia has 147 volcanoes and 76 of them are active volcanoes and spread along the islands of Java, Lesser Sunda, Sumatra, and Celebes. The characteristics of Indonesian volcanoes are quite unique in terms of the formation process, eruption phenomenon, and the resulting natural disasters. Most volcanoes in Indonesia consist of stratovolcanoes, but this does not mean that the resulting eruptions are always explosive and they have a long period. This can be seen from the activity of Semeru that always erupts effusively every day, Sinabung that has a very short eruption period, Tangkuban Perahu eruption that occurs suddenly with the lack of early signs, and Merapi and Kelud that have eruption period that is getting shorter. Based on the results of our study it can be known that the types of volcanic eruption are influenced by the structure of the constituent rocks of the volcanoes. However, the presence of external control factors in the form of large-scale earthquakes will affect their periodicity. The large earthquakes can affect the stability of the magma chamber that can trigger a premature eruption.",book:{id:"6104",slug:"volcanoes-geological-and-geophysical-setting-theoretical-aspects-and-numerical-modeling-applications-to-industry-and-their-impact-on-the-human-health",title:"Volcanoes",fullTitle:"Volcanoes - Geological and Geophysical Setting, Theoretical Aspects and Numerical Modeling, Applications to Industry and Their Impact on the Human Health"},signatures:"Eko Hariyono and Liliasari S",authors:[{id:"214360",title:"Dr.",name:"Eko",middleName:null,surname:"Hariyono",slug:"eko-hariyono",fullName:"Eko Hariyono"},{id:"219699",title:"Prof.",name:"Liliasari",middleName:null,surname:"S",slug:"liliasari-s",fullName:"Liliasari S"}]},{id:"51105",title:"How Polygenetic are Monogenetic Volcanoes: Case Studies of Some Complex Maar‐Diatreme Volcanoes",slug:"how-polygenetic-are-monogenetic-volcanoes-case-studies-of-some-complex-maar-diatreme-volcanoes",totalDownloads:1939,totalCrossrefCites:5,totalDimensionsCites:15,abstract:"The increasing number of field investigations and various controlled benchtop and large‐scale experiments have permitted the evaluation of a large number of processes involved in the formation of maar‐diatreme volcanoes, the second most common type of small‐volume subaerial volcanoes on Earth. A maar‐diatreme volcano is recognized by a volcanic crater that is cut into country rocks and surrounded by a low‐height ejecta rim composed of pyroclastic deposits of few meters to up to 200 m thick above the syn‐eruptive surface level. The craters vary from 0.1 km to up to 5 km wide and vary in depth from a few dozen meters to up to 300 m deep. Their irregular morphology reflects the simple or complex volcanic and cratering processes involved in their formation. The simplicity or complexity of the crater or the entire maar itself is usually observed in the stratigraphy of the surrounding ejecta rings. The latter are composed of sequences of successive alternating and contrastingly bedded phreatomagmatic‐derived dilute pyroclastic density currents (PDC) and fallout depositions, with occasional interbedded Strombolian‐derived spatter materials or scoria fall units, exemplifying the changes in the eruptive styles during the formation of the volcano. The entire stratigraphic sequence might be preserved as a single eruptive package (small or very thick) in which there is no stratigraphic gap or significant discordance indicative of a potential break during the eruption. A maar with a single eruptive deposit is quantified as monogenetic maar, meaning that it was formed by a single eruptive vent from which only a small and ephemeral magma erupted over a short period of time. The stratigraphy may also display several packages of deposits separated either by contrasting discordance surfaces or paleosoils, which reflect multiple phases or episodes of eruptions within the same maar. Such maars are characterized as complex polycyclic maars if the length of time between the eruptive events is relatively short (days to years). For greater length of time (thousands to millions of years), the complex maar will be quantified as polygenetic. These common depositional breaks interpreted as signs of temporal interruption of the eruptions for various timescales also indicate deep magma system processes; hence magmas of different types might erupt during the formation of both simple and complex maars. The feeding dikes can interact with groundwater and form closely distributed small craters. The latter can coalesce to form a final crater with various shapes depending on the distance between them. This observation indicates the significant role of the magmatic plumbing system on the formation and growth of complex and polygenetic maar‐diatreme volcanoes.",book:{id:"5311",slug:"updates-in-volcanology-from-volcano-modelling-to-volcano-geology",title:"Updates in Volcanology",fullTitle:"Updates in Volcanology - From Volcano Modelling to Volcano Geology"},signatures:"Boris Chako Tchamabé, Gabor Kereszturi, Karoly Németh and\nGerardo Carrasco‐Núñez",authors:[{id:"51162",title:"Dr.",name:"Károly",middleName:null,surname:"Németh",slug:"karoly-nemeth",fullName:"Károly Németh"},{id:"62029",title:"Dr.",name:"Gabor",middleName:null,surname:"Kereszturi",slug:"gabor-kereszturi",fullName:"Gabor Kereszturi"},{id:"182834",title:"Dr.",name:"Boris",middleName:null,surname:"Chako Tchamabé",slug:"boris-chako-tchamabe",fullName:"Boris Chako Tchamabé"},{id:"183809",title:"Dr.",name:"Gerardo",middleName:null,surname:"Carrasco-Núñez",slug:"gerardo-carrasco-nunez",fullName:"Gerardo Carrasco-Núñez"}]}],onlineFirstChaptersFilter:{topicId:"658",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188",scope:"This series will provide a comprehensive overview of recent research trends in various Infectious Diseases (as per the most recent Baltimore classification). Topics will include general overviews of infections, immunopathology, diagnosis, treatment, epidemiology, etiology, and current clinical recommendations for managing infectious diseases. Ongoing issues, recent advances, and future diagnostic approaches and therapeutic strategies will also be discussed. This book series will focus on various aspects and properties of infectious diseases whose deep understanding is essential for safeguarding the human race from losing resources and economies due to pathogens.",coverUrl:"https://cdn.intechopen.com/series/covers/6.jpg",latestPublicationDate:"June 25th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:13,editor:{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. 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He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. 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This topic will closely deal with all emerging trends in this discipline.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors"},{id:"17",title:"Metabolism",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation"},{id:"18",title:"Proteomics",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/45077",hash:"",query:{},params:{id:"45077"},fullPath:"/chapters/45077",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()