Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
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We wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\n
Throughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\n
We wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
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From their direct and recent experience, the readers can access the novel and ongoing potentialities of different synthetic and engineered biomaterials. Contributions reflect the fundamental studies, with a particular attention to the physico-chemical mechanical characterization of biomaterials, along with biocompatibility studies and potential clinical use. After an introductory chapter on the question of storage stability for biomaterial-based devices and products and for polymeric nanomedicines, a first review deals with the use and commercial sources of hydroxyapatite in tissue engineering and other biomedical applications. A study follows on optical fiber laser marking on the properties of stainless steel in implant manufacturing. Two other reviews, respectively, focused on the approaches to prevent or treat the effects of calcification that occurs in vivo on biomaterial-based implants and on the encapsulation of pancreatic islet cells for the treatment of type I diabetes will be presented. Finally, an overview on the physical bases and application in biomaterial science of the spray-drying process will close the volume. This setting will allow to achieve a general view of how classical and novel biomaterials can be applied, along with the methodologies necessary to design, develop, and characterize them, without the restrictions necessarily imposed by industrial or profit concerns. Readers will be apprised about the methodologies used to develop biomaterials possessing the physical and biological properties needed for specific medical and clinical applications.",isbn:"978-1-78923-065-9",printIsbn:"978-1-78923-064-2",pdfIsbn:"978-1-83881-376-5",doi:"10.5772/intechopen.69128",price:119,priceEur:129,priceUsd:155,slug:"biomaterials-physics-and-chemistry-new-edition",numberOfPages:114,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"4d45002a20a9496ff80f5c0166d9be33",bookSignature:"Rosario Pignatello and Teresa Musumeci",publishedDate:"May 2nd 2018",coverURL:"https://cdn.intechopen.com/books/images_new/6280.jpg",numberOfDownloads:12137,numberOfWosCitations:8,numberOfCrossrefCitations:22,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:56,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:86,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"July 10th 2017",dateEndSecondStepPublish:"July 27th 2017",dateEndThirdStepPublish:"September 18th 2017",dateEndFourthStepPublish:"December 17th 2017",dateEndFifthStepPublish:"February 28th 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"64447",title:"Prof.",name:"Rosario",middleName:null,surname:"Pignatello",slug:"rosario-pignatello",fullName:"Rosario Pignatello",profilePictureURL:"https://mts.intechopen.com/storage/users/64447/images/531_n.jpg",biography:"Prof. Rosario Pignatello is Full Professor of Pharmaceutical Technology and Legislation at the Department of Drug Sciences, University of Catania, Italy.\nHe is the member of the Directive Board of the Interuniversity Research Consortium ‘TEFARCO Innova’ (Parma, Italy) and member of the Directive Board of Controlled Release Society (CRS) - Italy Chapter) as well as of ADRITELF.\nHe is scientifically responsible of NANO-i (Research Centre for Ocular Nanotechnology, University of Catania). \nConsultant for the European Commission as an independent expert in the areas of Health, NMP, Environment (FP6, FP7, H2020). \nHe is also the main author/coauthor of 140 scientific publications and 160 among invited lectures, oral and poster contributions to scientific congresses. His main research interests are:\n- polymeric micro- and nanoparticles as modified drug delivery systems\n- lipophilic prodrugs and conjugates (drug-lipoamino acid conjugates)\n- Supramolecular Carrier Systems: liposomes and lipid-based nanocarriers for pharmaceutical and cosmetic applications\n- Synthesis and pharmaceutical applications of novel polymeric biomaterials\n- Brain and ocular drug delivery\n- Calorimetry (DSC) studies on vesicular biomembrane models",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"5",institution:{name:"University of Catania",institutionURL:null,country:{name:"Italy"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"209932",title:"Dr.",name:"Teresa",middleName:null,surname:"Musumeci",slug:"teresa-musumeci",fullName:"Teresa Musumeci",profilePictureURL:"https://mts.intechopen.com/storage/users/209932/images/5557_n.jpg",biography:"Professor Teresa Musumeci is Assistant Professor of Pharmaceutical Technology and Legislation at the Department of Drug Sciences, University of Catania, Italy.\nShe is a delegate of the Department of Drug Science at CinAP (assistance for students with disability) and the member of Controlled Release Society (CRS) - Italy Chapter and ADRITELF. She is the main author/coauthor of 30 peer-reviewed publications and 2 book chapters; she has attended the International/National meetings with oral/poster contributions. She is also the member of the Editorial Board of Pharmaceutical Nanotechnology. She is team member of Local and National Research Grant and her scientific activity is focused on:\n- Design, preparation and characterization of nanocarriers\n- Nanomedicine for anticancer therapy.\n- Nose to brain delivery of drugs loaded nanocarriers\n- Thermal analysis to study drug- biomembrane models interactions and to perform physico-chemical characterization of nanocarriers\n- Potential application of new polymers for nanocarriers preparation.",institutionString:null,position:"Assistant Professor",outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"154",title:"Biomaterials",slug:"biomaterials"}],chapters:[{id:"60489",title:"Introductory Chapter: Reduce the Gap from Bench to Bedside for Nanomedicines Increasing the Stability to Long-Term Storage",doi:"10.5772/intechopen.76541",slug:"introductory-chapter-reduce-the-gap-from-bench-to-bedside-for-nanomedicines-increasing-the-stability",totalDownloads:948,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Teresa Musumeci and Rosario Pignatello",downloadPdfUrl:"/chapter/pdf-download/60489",previewPdfUrl:"/chapter/pdf-preview/60489",authors:[{id:"64447",title:"Prof.",name:"Rosario",surname:"Pignatello",slug:"rosario-pignatello",fullName:"Rosario Pignatello"},{id:"250617",title:"Prof.",name:"Teresa",surname:"Musumeci",slug:"teresa-musumeci",fullName:"Teresa Musumeci"}],corrections:null},{id:"58222",title:"Spray Drying: An Overview",doi:"10.5772/intechopen.72247",slug:"spray-drying-an-overview",totalDownloads:6834,totalCrossrefCites:19,totalDimensionsCites:48,hasAltmetrics:1,abstract:"Spray drying is a well-known method of particle production which comprises the transformation of a fluid material into dried particles, taking advantage of a gaseous hot drying medium, with clear advantages for the fabrication of medical devices. In fact, it is quite common the production of microspheres and microcapsules designed for drug delivery systems. This review describes the different stages of the mechanism of the spray-drying process: atomization, droplet-to-particle conversion and particle collection. In particular, this work addresses the diversity of available atomizers, the drying kinetics and the importance of the configuration of the drying chamber, and the efficiency of the collection devices. The final properties of the dried products are influenced by a variety of factors, namely the spray dryer design, the feed characteristics and the processing parameters. The impact of those variables in optimizing both the spray-drying process and the synthesis of dried particles with desirable characteristics is discussed. The scalability of this manufacturing process in obtaining dried particles in submicron-to-micron scale favors a variety of applications within the food, chemical, polymeric, pharmaceutical, biotechnology and medical industries.",signatures:"Daniel Santos, Ana Colette Maurício, Vitor Sencadas, José\nDomingos Santos, Maria H. Fernandes and Pedro S. Gomes",downloadPdfUrl:"/chapter/pdf-download/58222",previewPdfUrl:"/chapter/pdf-preview/58222",authors:[{id:"56285",title:"Prof.",name:"Ana Colette",surname:"Maurício",slug:"ana-colette-mauricio",fullName:"Ana Colette Maurício"},{id:"161695",title:"Prof.",name:"José",surname:"Domingos",slug:"jose-domingos",fullName:"José Domingos"},{id:"215518",title:"MSc.",name:"Daniel",surname:"Santos",slug:"daniel-santos",fullName:"Daniel Santos"},{id:"215519",title:"Prof.",name:"Vitor",surname:"Sencadas",slug:"vitor-sencadas",fullName:"Vitor Sencadas"},{id:"215799",title:"Dr.",name:"Pedro",surname:"Gomes",slug:"pedro-gomes",fullName:"Pedro Gomes"},{id:"215800",title:"Dr.",name:"Maria Helena",surname:"Fernandes",slug:"maria-helena-fernandes",fullName:"Maria Helena Fernandes"}],corrections:null},{id:"57759",title:"Calcification of Biomaterials and Diseased States",doi:"10.5772/intechopen.71594",slug:"calcification-of-biomaterials-and-diseased-states",totalDownloads:1113,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Calcification is one of the most common issues that arise concerning biocompatibility, known to affect many systems in the body. It is often associated with an increase in free phosphate and calcium particles in the serum that leads to mineral deposition. Calcification is problematic both in the naturally occurring state of the body, as well as when it exists as result of biomaterial implants. While calcification is prominent in many different forms, not all mechanisms and processes associated with the phenomenon are completely understood. In this chapter, materials affected by calcification, potential mechanisms of action, and potential treatments will be discussed. Both bioprosthetic and polymer heart valves and urinary implants will be evaluated for material composition, application, and failure. Current research on the assessment of these materials will be reported, with the associated chemical and biological mechanisms explained. The chapter will also detail diseased states of the arteries that induce calcification and what treatments can be used for both arterial and bioprosthetic calcification. Finally, the chapter will conclude by detailing future designs for biomaterials to prevent and treat calcification in both natural and synthetic applications.",signatures:"Jenna Mosier, Nancy Nguyen, Kadie Parker and Chartrisa LaShan\nSimpson",downloadPdfUrl:"/chapter/pdf-download/57759",previewPdfUrl:"/chapter/pdf-preview/57759",authors:[{id:"217905",title:"Ph.D.",name:"C. LaShan",surname:"Simpson",slug:"c.-lashan-simpson",fullName:"C. LaShan Simpson"},{id:"221758",title:"Ms.",name:"Jenna",surname:"Mosier",slug:"jenna-mosier",fullName:"Jenna Mosier"},{id:"221759",title:"Ms.",name:"Nancy",surname:"Nguyen",slug:"nancy-nguyen",fullName:"Nancy Nguyen"},{id:"221760",title:"Ms.",name:"Kadie",surname:"Parker",slug:"kadie-parker",fullName:"Kadie Parker"}],corrections:null},{id:"57329",title:"Physical Protection of Pancreatic Islets for Transplantation",doi:"10.5772/intechopen.71285",slug:"physical-protection-of-pancreatic-islets-for-transplantation",totalDownloads:1176,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Type 1 diabetes is an autoimmune disorder that destroys the insulin producing cells of the pancreas. The mainstay of treatment is replacement of insulin through injectable exogenous insulin. Improvements in islet isolation techniques and immunosuppression regimens have made islet transplants a treatment options for select patients. Islet transplants have improved graft function over the years, however, graft function beyond year two is rare and notably these patients require immunosuppression to prevent rejection. Cell encapsulation has been proposed for numerous cell types but it has found increasing enthusiasm for islets. Since islet transplants have experienced a myriad of success the next step is to improve graft function and avoid systemically toxic immunosuppressive regimens. Cell encapsulation hopes to accomplish this goal. Encapsulation involves encasing cells in a semipermeable biocompatible hydrogel that allows the passage of nutrients and oxygen however blocks immune regulators from destroying the cell thus avoiding systemic drugs. Several advances in encapsulation engineering and cell viability promises to make this a revolutionary discovery. In this chapter, we will provide a review of islet encapsulation as used for the treatment of type 1 diabetes.",signatures:"Sarah Lee, Mayilone Sathialingam, Michael Alexander and\nJonathan Lakey",downloadPdfUrl:"/chapter/pdf-download/57329",previewPdfUrl:"/chapter/pdf-preview/57329",authors:[{id:"188950",title:"Prof.",name:"Jonathan",surname:"Lakey",slug:"jonathan-lakey",fullName:"Jonathan Lakey"},{id:"189626",title:"MSc.",name:"Michael",surname:"Alexander",slug:"michael-alexander",fullName:"Michael Alexander"},{id:"222160",title:"BSc.",name:"Sarah",surname:"Lee",slug:"sarah-lee",fullName:"Sarah Lee"},{id:"222161",title:"Mr.",name:"Mayilone",surname:"Sathialingam",slug:"mayilone-sathialingam",fullName:"Mayilone Sathialingam"}],corrections:null},{id:"58378",title:"Electrochemical Characterization of an Optical Fiber Laser- Treated Biomaterial",doi:"10.5772/intechopen.72653",slug:"electrochemical-characterization-of-an-optical-fiber-laser-treated-biomaterial",totalDownloads:874,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The implant manufacturing process includes texturization to enhance its adhesion and marking the final products for their identification, long-term quality control and traceability. Marking is carried out after cleaning and prior to sterilization. These marks eventually can concentrate stress leading to premature failure. The marked areas are defective regions that affect the passive film formed on the metallic biomaterials used for implants favoring the onset of various corrosion types, such as pitting, crevice or fatigue. This study aims to evaluate the effect of a Yb optical fiber laser marking processes used for metallic implants on the localized corrosion resistance of the austenitic stainless steel ISO 5832-1. This is one of the most used materials for manufacturing implants. The electrochemical behavior of the marked areas obtained by this method was evaluated in a phosphate-buffered saline (PBS) solution with pH of 7.4 and the results were compared with unmarked samples. All tested surfaces were prepared according to the recommendations for the use in surgery. For localized corrosion resistance evaluation, electrochemical tests such as monitoring the open circuit potential (OCP), electrochemical impedance spectroscopy (EIS) and cyclic potentiodynamic polarization measurements were performed. The results showed that the laser marks affect the protector characteristics of the biomaterial’s passive film. Lower pitting resistance was associated to the laser marked areas.",signatures:"Eurico Felix Pieretti, Olandir Vercíno Corrêa, Marina Fuser Pillis and\nMaurício David Martins das Neves",downloadPdfUrl:"/chapter/pdf-download/58378",previewPdfUrl:"/chapter/pdf-preview/58378",authors:[{id:"98550",title:"BSc.",name:"Olandir",surname:"Correa",slug:"olandir-correa",fullName:"Olandir Correa"},{id:"218783",title:"Dr.",name:"Eurico",surname:"Pieretti",slug:"eurico-pieretti",fullName:"Eurico Pieretti"},{id:"222974",title:"Dr.",name:"Maurício David Martins",surname:"Neves",slug:"mauricio-david-martins-neves",fullName:"Maurício David Martins Neves"},{id:"223680",title:"Dr.",name:"Marina",surname:"Pillis",slug:"marina-pillis",fullName:"Marina Pillis"}],corrections:null},{id:"57755",title:"Tuned Hydroxyapatite Materials for Biomedical Applications",doi:"10.5772/intechopen.71622",slug:"tuned-hydroxyapatite-materials-for-biomedical-applications",totalDownloads:1197,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Hydroxyapatite stands out between biomaterials due to its properties of osteoconduction and osteoinduction, being adequate to be used in bone grafts. The high stability and flexibility of the structure allows for several biomedical applications, for example, the use as polysaccharide based on the scaffold formulations and the cationic substitutions occurring through the doping of the material using metals, which may enhance biological characteristics, such as improving the action of combating bacterial infections in situ. This study was a research of articles and patents, without and with time restriction (2007–2017), which contain information about hydroxyapatite in the tissue engineering, biomedical, doped with cerium and its properties of antibacterial activity. There were also searches of products and companies that commercialize these types of materials aimed at tissue engineering area. Scopus was used for searched of articles and were EPO, USPTO, and INPI used for patents, and to search for products and companies were used search engines. Few papers were found to associate all the keywords, but the ones found are recent works, thus showing a new area with potential to be investigated.",signatures:"Ewerton Gomes Vieira, Thátila Wanessa da Silva Vieira, Marcos\nPereira da Silva, Marcus Vinicius Beserra dos Santos, Carla Adriana\nRodrigues de Sousa Brito, Roosevelt Delano de Sousa Bezerra, Ana\nCristina Vasconcelos Fialho, Josy Anteveli Osajima and Edson\nCavalcanti da Silva Filho",downloadPdfUrl:"/chapter/pdf-download/57755",previewPdfUrl:"/chapter/pdf-preview/57755",authors:[{id:"175812",title:"Prof.",name:"Edson",surname:"Cavalcanti",slug:"edson-cavalcanti",fullName:"Edson Cavalcanti"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"1487",title:"Biomaterials",subtitle:"Applications for 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1. Introduction
1.1. Energy crisis and emission regulations
Oil price is increasing rapidly due to the oil reserve limited as a non-renewable resource. The proportion of the fuel cost rises in the total operating costs of ocean transportation companies. Compared with those from vehicles, the emissions of NOX and SOX from marine diesel engines are more serious, but the ones of CO2, CO and HC are lower relatively. According to the statistics from International Maritime Organization (IMO), tens of millions tons of NOX and SOX are expanded into the atmosphere annually. An international protection regulation for the prevention and the control of marine pollution from ships—Amendments to MARPOL Annex VI—is adopted at Maritime Environment Protection Committee (MEPC) 58th meeting in October 2008. The detailed NOX emission targets of marine diesel engines are shown in Table 1. At present the techniques of energy conservation and emission reduction are the future technical developing direction of marine diesel engines and the research highlights for producers and institutes.
Rated revolution n (r/min)
n<130
1≤n2000
n"/>2000
Tier I (2000) g/kW*h
17.0
45*n-0.20
9.84
Tier II (2011)g/kW*h
14.36
44*n-0.23
7.66
Tier III (2016)g/kW*h
14.36
44*n-0.23
7.66
Tier III (2016)g/kW*h(ECA)
3.40
9*n-0.20
1.97
Table 1
IMO NOX emission standard
The primary technical methods to improve performance and to reduce emissions for marine diesel engine are shown below:
The density of intake air is increased through the turbocharging technology.
To raise the volumetric efficiency of the cylinder, the advanced techniques such as variable exhaust valve timing are used for improving the performance of intake and exhaust.
High pressure fuel injection is used to optimize fuel atomization and mix-ability of fuel and fresh air.
Fuel injection, mix and combustion are improved under variable working conditions by using suitable injection timing (VIT) based on fuel injection control system.
High-pressure common-rail (HPCR) electronic control technology is one of the most effective techniques to increase heat efficiency and to reduce emissions and noise for diesel engine. The fluctuation of the fuel injection pressure is not associated directly with diesel engine’s speeds and loads. It means that the fuel injection pressure is independent in different conditions, especially the low-load condition. The performance parameters of the diesel engines, including excess air coefficient, combustion starting pressure, fuel atomization, are optimized through the flexible control of the fuel injection quantity, the injection plus width, the injection timing, the variable exhaust valve timing and etc. The fuel consumption and NOX, PM emissions can be decreased substantially with the techniques implementation.
1.2. Hardware-in-loop simulation technology
Hardware-in-loop (HIL) simulation system is a close-loop dynamic testing system, composed of mathematic models and real-world physical parts. The mathematic models are established to simulate some other real-world physical parts which are non-existence or non-available for experiments in the system. HIL simulation technique is contributed to testifying the validity and feasibility of a designed proposal about the control system due to its flexible configuration. While some system settings change, the performance variation of the object measured can be observed simultaneously. Recently HIL simulation technique is widely used in developing the electronic control system of diesel engine, and it is acting as an important role during developing process. The benefits of HIL simulation system are shown in the following aspects:
A comprehensive emulation experimental environment is provided for the hardware and the control strategy certification. In addition, the experimental data can be as the evaluation index for the hardware being selected and matched.
The different working conditions of the engine can be simulated for testing software functions and control strategies. And a HIL simulation system can be applied to different projects due to its repeatability. The experimental cost on a HIL simulation system is reduced compared with that on a real diesel engine bench.
The initial calibration of electronic control system can be realized. The simulated engine model can be used to match and to demarcate basic control parameters to reduce developing period.
HIL simulation system is available for mass tests of system reliability.
When a electronic control system is tested by a HIL simulation system, it is easy to control and to record the testing process, and it is convenient to analyze and optimize the objects via calculating results from the models.
Normally, there are mainly four types (Figure 1) of HIL simulation system for different uses.
The first type HIL is mainly used in ECU developing and testing. The engine and mechanism are simulation models, but the ECU is real. This type
The second type HIL is mainly used in mechanism testing. The engine and ECU are simulation models, but the mechanism is real.
The third type HIL is mainly used in testing the combination of ECU and mechanism. The engine is simulation model, but the ECU and mechanism are real.
The fourth type HIL is mainly used in ECU developing and testing. The engine and mechanism are simulation models, but the ECU is real.
Figure 1.
Application type of the simulation technique
The first type HIL cannot involve the entity of the engine and the mechanism, and the hardware costs of HIL are low relatively, besides the modeling methods are mature relatively, so the real time simulation technique is developing rapidly and widely used. The main corporations of real-time simulation system platform are dSPACE (Germany), ADI (U.S.A) and NI (National Instrument, U.S.A) platform. Since 2005, NI corporation (National Instrument, U.S.A) has introduced PXI (PCI eXtensions for instrumentation) hardware platform with the RTOS (Real Time Operation System), which have combined its abundant I/O hardware resources, and have provided more choices to realize HIL real-time simulation system. There are many investigations on the first type HIL. F. R. Palomo Pinto realized HIL simulation of a fuel system using two PXIs with RTOS[1]. R. Isermann and J. Schaffnit realized HIL simulation system for ECU design and test using dSPACE[2]. Zhang Jie realized HIL simulation of high pressure common rail diesel engine on a common PC, using Linux RTAI[3]. The satisfactory effects have been obtained. The real-time feature of the model is required strictly in the first type HIL system.
As for the second type HIL, Bosch (Germany) in cooperation with EFS (Germany) developed a system testing platform, which has become more mature and widely used in recent years. According to the test requirements, users can set ECU model control parameters on the testing platform, such as the common rail pressure, the rail pressure control parameter, the pulse width of the fuel injection, the injection rate and so on. The research institutions and universities also successfully developed many testing platforms according to their research content and object. Wang Zhigang developed a middle pressure common rail diesel engine system testing platform[4]. Catania A. E. and Ferrari A. replaced the common rail ripe of Moehwald-Bosch testing platform by a high-pressure oil pipeline of smaller diameter. And the effect of the change to the fuel injection process is also accounted [5]. Shanghai Jiao Tong University and Shanghai Marine Diesel Engine Institute cooperated to develop the high pressure common rail fuel injection system reliability test platform[6]. The second type HIL has little demand of the engine models. ECU can only realize simple pressure control and electromagnetic valve control pulse output. Since there is no MAP of the fuel injection pressure and the fuel charge matching the engine load, it is impossible to combine the performance of the high pressure common rail system and the diesel engine load to research deeply on.
As for the third type HIL, Song Enzhe developed a semi-physical simulation platform according to type 16V396TE94 marine diesel engine and electronic control system[7]. The results of the experiments show that semi-physical simulation platform can be used for testing the diesel engine electronic control system in laboratory conditions, and the development cycle time can be shorten, and test costs can be reduced. Ou Dasheng designed a high-pressure common rail system test platform and carried out a series of tests on the platform[8], which includes the response characteristics of a high-speed solenoid valve, the hydraulic response of a electronically controlled fuel injector, the atomization characteristics of a high-pressure common rail system, the control of a common rail chamber pressure volatility, the common rail high pressure pump seal and seal ability, the solenoid valve fuel injector fuel injection characteristics and ECU performance tests. A higher reliability of the engine model is required in this kind of application.
The fourth type HIL is very close to a complete and original diesel engine. Shanghai Jiao Tong University designed a electronically controlled high pressure common rail diesel engine test bench system basing on GD-1 HPCR diesel engine, using the designed system to match and to calibrate the electronic control system of HPCR[9].
In summary, almost all the test benches of HPCR electronic control system are suitable for high and middle speed diesel engines, but there are rare reports and papers to introduce the test bench for the low-speed marine diesel engine.
2. HPCR electronic control system of low-speed marine diesel engine
2.1. Introduction
Nowadays the low-speed marine diesel engines with HPCR have successfully been put into commercial operation. These marine diesel engines with HPCR mainly include Wärtsilä RT-flex (Flex control) type marine diesel engine, MAN ME (Electronic control) type marine diesel engine and Japan Mitsubishi UEC Eco (emission control) type marine diesel engine. The first two corporations have accounted for more than 90% marine diesel engine with HPCR market shares.
2.2. RT-flex type marine diesel engine
The system architecture is shown in Figure 2. Comparing with a traditional diesel engine, RT-Flex marine diesel engine removed some components, such as exhaust valve drive devices, fuel pump, camshaft, servo motor for direction change, fuel connecting rod, starting air distributor and camshaft drive. These components are replaced with a fuel supply unit, a common-rail unit, an injection control unit, an exhaust control unit and WECS (Wärtsilä Engine Control System). WECS outputs 24V DC pulse signals to control the mechanical movement of the fuel injection and the exhaust valve behave via the high-speed solenoid valves and hydraulic forces. High-speed switching solenoid valves in the fuel injection control unit and the exhaust valve control unit are driven by the electromagnetic force, while hydraulic force is generated by high pressure servo oil in the servo oil common rail pipe. On the basis of the varied working conditions of the marine diesel engine, WECS can offer the flexible control of the injection start angle, the fuel injection pulse width and the open and the close angles of the exhaust valve, besides the mechanical delay is also fully considered. Multi-injection system (multi-jet system) is employed with the assembly of many injectors per cylinder. Three injectors were mounted with each cylinder in bore 600 mm and above of RT-flex marine diesel engine, but two injectors mounted with each
Figure 2.
HPCR electronic control system of RT-flex
cylinder in bore 600 mm and below of RT-flex marine diesel engine. When the marine diesel engine starts, the start air valve on the upper cylinder is open and piston drives crankshaft rotating with the start air (3 MPa) via the 24V DC pulse control signals generated by WECS.
2.2.1. Oil supply unit
As is shown in Figure 3, the structure integrated is adopted in HPCR oil supply unit of RT-flex series marine diesel engine, with the features of a small footprint and easier installation and maintenance. The fuel pump, the servo oil pump, and the respective conduction-powered three-phase drive camshaft and the driving shaft are combined into a compact independent structure. The driving force for the oil supply unit is provided by gears set at the free end of the crankshaft. There is a fixed ratio between the speed of the camshaft, the crankshaft and the marine diesel engine crank (Speed of crank: Speed of Camshaft: Speed of the crankshaft=1:2.5:11.9).
Figure 3.
Oil supply unit of RT-flex
2.2.2. Common rail unit
As is shown in Figure 4, the common rail unit includes the fuel common rail pipe and the servo oil common rail pipe. The fuel common rail of 5RT-flex60C can afford the 100MPa pressure with the 5616 mm length and the peanut inwall. The operating pressure of the servo oil is the 20MPa with 5287 mm length and the round inwall. The fuel injection control unit is directly attached to the common rail fuel pipe, and the exhaust control unit is directly attached to the servo oil common rail. According to the fuel pressure signals of two pressure sensors set at the end of fuel common rail, the fuel pressure control signals are sent out to adjust the rotation angle of the fuel pump plunger cylinder from WECS, to accomplish a closed-loop control of the fuel common rail pressure. Similarly, a closed-loop control of the servo oil common rail pressure is still under WECS. Servo oil pressure signals are sent out by two pressure sensors set at the end of the servo oil common rail, and WECS adjust the servo pump swash plate tilt angle thus changing the fuel supply of the servo pump and accomplish a loop-locked control of the servo oil common rail pressure.
Figure 4.
Common rail unit of RT-flex
2.2.3. Injection control unit
Figure 5 shows the injection control unit schematic structure of a single cylinder in no injection status. Injection rail valve converts to the open state under the excitation of the start pulse signals from WECS, then the high-pressure servo oil flow into the injection control valve. When the pressure produced by the servo oil is higher than the spring pre-tightening force, the state of the valve will change. The inlet oil line at the left side is closed, and the outlet oil line is opened. Because the pressure at the right side of the piston is higher than that at the left side, the piston is pushed to move to the left, meanwhile the high pressure fuel get into the injectors. The injection rail valve converts to the close state under the excitation of the close pulse signals from WECS, then the injection control valve will reset under the action of the spring. The outlet oil path at the left side of piston closes, while
Figure 5.
Principle of injection control unit. ① Injection rail valve ② Injection control valve ③ Injector ④ Fuel piston
the inlet oil path opens. Although the pressure on both sides of the piston is approximately same, the discrepancy of the area is existed. The piston moves right back under the pressure differential, and the fuel pressure in the injector reduces. Based on the current crank angle and the actual fuel quantity calculated from the displacement of the fuel piston, WECS triggers the fuel injection order and correct the injecting angle.
2.2.4. Exhaust control unit
Figure 6 shows the principle of exhaust valve control unit when a single-cylinder exhaust valve is closed. It is mainly consist of ① exhaust rail valve, ② exhaust control valve, ③ isolated transmission device, ④ exhaust valve and ⑤ air spring and so on. According to the current crank angle, WECS triggers the opening and closing orders of the exhaust valves. The exhaust valve lift is used to detect the open\\ close process and the open\\close angle of the exhaust valve.
Figure 6.
Principle of Exhaust Control Unit
2.2.5. ECU for RT-Flex diesel engine
WECS of RT-flex marine diesel engine includes six FCM-20 modules (Figure7). The FCM-20 module assembled on the cylinder is used to control start air valves, exhaust rail valves and fuel injection rail valves, and a single one is provided as online spare. Two FCM-20 modules of the cylinder 1 and the cylinder 2 are connected to AC20 speed control system. Three servo pumps are controlled separately by three FCM-20 modules of the cylinder 2, the cylinders 3 and the cylinders 4. And also a set of the fuel pumps (2-3per set) is controlled by two FCM-20 modules of the cylinder 3 and the cylinder 4. The functions of FCM-20 module are described in Table 2. Each FCM-20 has the same structure of hardware sub-systems. Some of them are indispensable for each cylinder, such as CYL-EU and VDM, while some of them are shared, such as COM-EU, MCM and CAN. Therefore, the functions and running parameters of each FCM-20 modules are set through the Flex-View software at the beginning configuration of WESC.
Figure 7.
Structure of WECS
Number
Definition
Function
1
COM-EU
Communication and pressure control of the fuel common rail
2
ASM
Checking for the MCM
3
MCM
Communication and pressure control of the servo oil common rail
4
CAN
PWM signal output
5
CCM
Calculation for fuel quality, injection timing and exhaust valve timing
6
CYL-EU
Control for injection and exhaust valve
7
VDM
Amplifying the driven signal
Table 2
Function of the FCM-20 module
2.3. ME type marine diesel engine
ME marine diesel engine mainly consists of a hydraulic-machinery system for opening fuel injection valves and exhaust valves. The major executive components include two three-way solenoid valves, booster pumps, fuel injectors and electronic control exhaust valve, etc. As shown in Figure 8, there is only one high-pressure servo oil common rail in the HPCR system. The servo oil pump is driven by the diesel engine through the gear delivers high-pressure servo oil of 20MPa to the servo oil common rail. Then the high-pressure servo oil drives the booster pump and the exhaust valve piston through the solenoid valve. In the fuel oil system, each cylinder is assembled with a fuel oil pressure booster separately. With the help of the servo oil pressure, the fuel pressure rises from 1MPa to 75 - 120MPa. The solenoid valves control the movement of the plunger via the flow of the hydraulic oil, thus the controls of the fuel injection timing, the injection pressure and the fuel injection quantity are carried out.
Figure 8.
HPCR electronic control system of ME
2.3.1. Injection control unit
As is shown in Figure 9, the fuel injection control unit of ME-type marine diesel engine is called ELFI (Electronic Fuel Injection). The major component is a three way solenoid valve (NC Valve). The high-pressure servo oil flows into the fuel booster after the NC Valve opening. The area differential of the piston\'s two end caused high-pressure fuel injection. According to the fuel piston displacement, the actual fuel injection quantity is calculated and fuel injection angle is corrected in real time. The accurate control of the servo oil quantity can be achieved by the high-speed open and close action of NC valve. According to the different load conditions, it not only can achieve the change of the fuel injection timing angle and the cycle fuel injection quantity, but also can achieve fuel injection with the different fuel injection law.
Figure 9.
Injection control unit
2.3.2. ECU of ME diesel engine
As is shown in Figure 10, the electronic control system of ME diesel engine is divided into diverse function models in accordance with the different purposes.
Figure 10.
Structure of the electronic control unit
EICU (engine interface control unit) is responsible for interfacing with external system.
ECU (engine control unit) accomplishes the control functions of marine diesel engine, such as the speed, the operating mode and the starting sequence, etc.
ACU (auxiliary control unit) controls the hydraulic power supply unit of the pump and the auxiliary blower.
CCU (cylinder control unit) controls ELFI, ELVA (electronically controlled exhaust valve), SAV (air start valve), ALS (Alpha lubrication system) and HCU (hydraulic cylinder unit, including two parts of the fuel booster and exhaust valve actuator) of each cylinder.
Each module is installed in different parts of the marine diesel engine with the different control object and the function, as well as a set of backup module is set for the redundancy.
2.4. Comparative analysis between RT-Flex and ME
2.4.1. Similar points
In both types of the marine diesel engines, the mechanical control cams from traditional engine types are discard, which is used as the control core of the fuel injection and the exhaust valve timing, and replaced by the more precise and flexible ECU and electric-liquid-machine switching equipment[10]. The revolutionary improvement offers the low-speed marine diesel engine more flexibly features in adjusting control parameters, for instance the fuel injection timing, the fuel injection pulse width, the exhaust valve timing and etc. Air-fuel ratio, the pressure of the combustion starting point, the fuel atomization rate can be optimized, so the reduced fuel consumption and emissions are realized under the different conditions. Especially in the low-load working condition, the influence of NOx emission reductions is more obvious. The technique of high pressure fuel injection is adopted in the two types to improve the fuel atomization rate. The technique also guarantees the steady running of the diesel engine at the low speed and the low load. The minimum steady speed of the two types can reach 15 rounds per minute.
2.4.2. Dissimilar points
HPCR system of ME marine diesel engine is a pressure-charged system including the servo oil and the fuel. The fuel pressure of the common-rail is maintained at a medium level, for the pressure is set up by the booster oil pump. In the pressurized structure, the shape distortion of the common rail is small, and the sealing performance of the solenoid valve is less required, and the processing difficulty of exactitude parts is reduced. However, more fuel booster pumps are needed. The complexity and maintenance costs of the system increase.
HPCR system of RT-flex marine diesel engine also has two sets of oil ways. Fuel pressure is set up by oil supply units directly, so it is no necessary to boost pressure. The solenoid valves are used as the pilot valves with the lower flow rate and the response requirement. When the solenoid valves are opened, the piston is moved to make the fuel common rail and fuel atomizer connected. Because the pressure of the fuel common rail is kept at 100Mpa frequently, it is hard difficult to process the common rail.
3. Development of HIL simulation tested bench of HPCR electronic control system
3.1. Design of HIL simulation test bench of HPCR electronic control system
3.1.1. Structure of HIL simulation test bench
Various types of RT-flex series marine diesel engines are distinguished with the number of cylinders and the cylinder bore. There are not only 5 cylinders, 7 cylinders, 9 cylinders, 14 cylinders for RT-flex series marine diesel engines, but also the cylinder diameters cover 50 mm, 58 mm, 60 mm, 84 mm, 96 mm, etc. Although HPCR system structure, the length and the diameter of the common-rail pipe, the number of the fuel pumps and the servo oil pumps, and the number of injector per cylinder are slightly different for the specific type, the functions and principles are similar to each type including WECS and HPCR system, the common-rail technology with the fuel and the servo oil, the centralized supply unit for the high pressure fuel and the servo oil, the fuel injection control unit and the exhaust control unit, the system integration and the information communication technology. Those mentioned above are just the key parts that RT-flex type marine diesel engine is different with the traditional marine diesel engine. Based on the 5RT-flex60 CMKII HIL test bench is designed. The main technical parameters of the 5RT-flex60 CMKII are shown in Table 3.
Num.
Parameter
Unit
Value
1
Number of cylinder
—
5
2
Stroke
—
2
3
Bore
m
0.6
4
Pistonstroke
m
2.25
5
Rated power
kW
11800
6
Rated speed
r/min
114
7
Compression ratio
—
16.5
8
Fire order
1-4-3-2-5
Table 3
Main parameters of the 5RT-flex60CMKII
HPCR electronic control system of RT-flex series marine diesel engine is a cohesive whole according to the structure and function. The fuel supply unit, the common rail unit, the fuel injection control unit and the exhaust control unit are controlled by WECS. HIL simulation test bench is designed with integrated structure and the application type—Real-time simulation model of marine diesel engine, Control unit and executing mechanism. So the original structure characteristics and the functions of RT-flex series marine diesel engine are retained, and the system errors from the boundary conditions of the test bench are reduced. The structure integrated of HIL simulation test bench is divided into HIL simulation system and monitoring system [11], which is shown in Figure 11. Two parts are independent of each other, in addition the parameters and the data mainly are transferred via CAN bus. On HIL simulation test bench, the electronic control unit is WECS from the original machine, and the executive mechanism is properly simplified and improved based on the HPCR system of
Figure 11.
The structure of HIL simulation test bench
5RT-flex60C. Even more important, the real-time simulation model of the marine diesel engine which consists of the working process simulation unit and the exhaust valve simulation unit, is built up to keep the bench working well. The monitoring system of the bench is carried out for collecting, displaying and recording the test bench parameters. NI LabVIEW is served as the software development kit, besides the model and monitoring system are eployed separately in the compactRIO controller and PXI computer (from NI Corporation). The PXI is set in a console which including the Auto Chief 20 propulsion control system exporting the set point of the marine engine speed, and the load simulation device exporting physical signal for simulating the change of the engine load.
3.1.2. Functions of HIL simulation test bench
Performance tests of HPCR electronic control system
The different working states of the diesel engine including starting, accelerating, decelerating, mutating and steady working can be simulated throughout HIL simulation test bench. So the bench can be used for the research on the control strategies and the working characteristics of HPCR electronic control system. All parts of the bench work together harmonically. The common-rail pressure, the fuel injection and the exhaust valve movement are controlled by WECS, while the different working conditions of the diesel engine are simulated by the real-time simulation model. The signals of the crankshaft angle, the fuel pump rack position, the fuel common-rail pressure, the servo oil common-rail pressure, the fuel injection quantity, the needle valve lift, the exhaust valve lift, the control from WECS are measured by the monitoring system.
Fuel injection characteristic tests
The objective of the test is to conduct the dynamic working characteristics of the fuel control unit and injector. The fuel injection system is in running state independently, and some important parameter signals related to the fuel injection system, such as the crankshaft angle, the fuel common-rail pressure, the fuel injection quantity, the needle valve lift and reference injection signals from WECS are acquired and analyzed. However, the exhaust valves do not work, and the exhaust valve lift signals and various load working conditions of the diesel engine are simulated via the model.
Exhaust valve characteristic tests
The objective of the test is to conduct dynamic working of the exhaust control unit and the exhaust valve. The exhaust system is in running state independently, and some important parameter signals which include the crankshaft angles, the servo oil common-rail pressure, the exhaust valve lift and the reference control are acquired and analyzed. However, the fuel injection system does not work, and the various load working conditions of the diesel engine are simulated via the model.
Key executive mechanism tests
The key executive mechanisms of the high pressure common-rail system contain the fuel pump, the servo oil pump, the common-rail pipe, the fuel accumulator, the fuel injector, and the exhaust valve, etc. The performance tests of the parameters comparison for the executive mechanism can be proceed by applying the replacement way, also the executive mechanism can be tested independently.
3.2. Executive mechanisms of HIL simulation test bench
The sketch map of executive mechanisms is shown in figure 12. It is no feasibility that the same executive mechanisms from the 5RT-flex60C diesel engine are used for the test bench due to the huge structure. In the premise condition that the test bench can realize the integrated original system function, the fuel supply unit and the exhaust valve unit are simplified based on HPCR system. The tubing length, the diameter, the bending angle of the connector of the executive mechanism are close to the original machine as much as possible, and the key components which need to be focused on are retained. The common and non-key components are simplified and improved. An auxiliary system unit is added for providing the boundary conditions for the test bench. The auxiliary system unit is composed of the low pressure oil supply unit, compressed air unit, crank angle unit and fuel weighing unit.
Figure 12.
The sketch map of executive mechanism
Oil supply unit
The research on the fuel supply unit focuses on the oil supply way, the electronic control technology and the characteristics of the fuel pump and the servo oil pump, etc. The key components, which can reflect the functional structure characteristic, are kept such as the three-phase power cam and the fuel accumulator etc. To satisfy the function of HIL test bench and site layout, some simple components are replaced on the basis of the reliable equipment designed with the advanced and proven technique. The number of the fuel pump is 2, the one of which on the 5RT-flex60C diesel engine is 4. The number of the servo oil pumps is reduced from 3 to 1. Two sets of the variable-frequency adjustable-speed three-phase induction motors (be referred to as "fuel pump motor" and "servo oil pump motor") are served as the power of the oil supply unit. The speeds of motors are controlled by the real-time simulation model of the diesel engine, but the flow is controlled by WECS.
Common-rail unit
The common rail unit including the fuel common rail and the servo oil common rail is conformity to that of the original machine.
Fuel injection control unit
The fuel injection control unit is consistent with that of the original machine, which has one fuel injection control unit and three injectors per cylinder.
Exhaust control unit
Due to the similarity of the exhaust valves movements, only one cylinder exhaust valve is retained. The exhaust control units installed on each cylinder are conformity to that of the original machine. Furthermore a 40L nitrogen bottle is used to provide the pressure for the air spring.
Crankshaft angle unit
Crankshaft angle signal is provided for WECS by the crankshaft coder driven by an AC servo motor (be referred to as "crankshaft motor"). The motor speed can be controlled by the real-time simulation model of the diesel engine.
Fuel weighing unit
Fuel weighing unit is two movable carriages comprised by three electronic balances and container. It is used to weighing the fuel injection quantity of three fuel injectors in the cylinder during a certain time or a certain cycle.
Low pressure fuel supply unit and compressed air unit
Low pressure fuel supply unit is taken for recycling the backflow or the leakage fuel, the servo oil and the lubricating oil after multi-stage filtration. Compressed air unit provides compressed air of 0.5 ~ 0.75MPa by using Ingersoll-Rand Company UP5-15-7 type air compressor, to simulate the back gas pressure in the cylinder.
3.3. Real-time diesel engine simulation model
As the half of the working process simulation unit, the real-time diesel engine simulation model is used to simulate the diesel engine working process for coordinating synchronous operation of the test bench. The closed-loop system (Figure13) is composed by the real-time model, HPCR system, WECS and the console. The features of the real-time model are:
To start three motors of the crankshaft angle, the fuel pump and the servo oil pump simultaneously through the enabling signals after detecting the control pulse signals of the starting air valves from WECS.
To calculate the motors speed and scavenging pressure with the displacement signals of the fuel quality piston.
To generate 4-20 mA signals to control the speed of three motors respectively.
To simulate the load and propulsion characteristics of the diesel engine with the load torque set on the console.
To generate two consistent simulated scavenging pressure signals to WECS.
To monitor the crankshaft angle and simulate backpressure in the exhaust valve through opening the pneumatic valve with the exhaust valve at the closing statue, and allow the compressed air go into a seal space at the bottom of exhaust valve.
Figure 13.
Schematic diagram of the working process simulation unit
Number
Crankshaft motor state
Control plus for staring air
Injecting
State
1
Stop
0V
No
Stopping
2
Stop
0V
Yes
—
3
Work
0V
Yes
Running stage
4
Work
0V
No
Stopping procedure
5
Stop
24V
No
Staring
6
Stop
24V
Yes
—
7
Work
24V
Yes
—
8
Work
24V
No
Staring procedure
Table 4
States of HIL simulation test bench
The executive mechanism status of HIL simulation test bench can be divided into eight forms shown in Table 4, according to crankshaft motor running, control pulse signal amplitude of starting air valve and the existence of injection process during a cycle of crankshaft motor. The different algorithms are designed to deal with different possible situation. Because injection order from WECS cannot be sent out when crankshaft motor stops or the starting air valve is open, the number 2, 6 and 7 will not appear. The others are the contents focused on.
3.3.1. Staring and staring procedure
At the staring stage of RT-flex marine diesel engine, the crankshaft position is calculated and the control pulse is outputted to open the starting air valve by WECS. Then the compressed air is blown into the cylinder to make the crankshaft rotate by pushing the piston. After a period of time, if the engine speed and the fuel common-rail pressure both reach the expected values, starting is success. On the contrary it is fail. Staring process is shown in Figure 14.
Figure 14.
The flowchart of the starting
The primary control parameters in the process of diesel engine staring are shown in Table 5 and the opening angles of the starting air valve are shown in Figure 15, which come from experimental data of HIL simulation test bench.
Number
Category
Value
1
The waiting time(s)
15
2
The speed expected (r/min)
25
3
The pressure expected(MPa)
40
Table 5
The primary parameters in the starting process
Figure 15.
The opening angles of starting valve
As Figure16 is shown, the scavenging pressure () is set 0.01MPa to simulate the real scavenging pressure of entity auxiliary fan. When the starting air valve control pulses are detected from any FCM-20 module, three motors will be started synchronously in the bound mode. However, in the non-bound mode only the crankshaft motor motor will be started.
With the curve fitting method, the crankshaft motor speed (r/min) is regarded as the time logarithmic function according to the formula (1), and has to reach 25 (r/min) during 15 seconds. The current speed (r/min) is calculated by formula (2) according to the crankshaft angle difference in 10 seconds. In the bound mode, the fuel pump motor speed (r/min) and the servo oil pump motor speed (r/min) are calculated respectively according to formula (3) and formula (4). Parameter is the constant. Parameter is the time (ms). Parameter is the fuel pump bound parameter referring to chapter 2. Parameter is the servo oil pump bound parameter referring to chapter 2.
Figure 16.
The control flowchart of the starting
E1
E2
E3
E4
3.3.2. Running stage
The simulation model of 5RT-flex60C at the running stage is restricted by the following conditions and design requirements.
The filling and emptying method can’t be applied to the mathematical model of the diesel engine, because key parameters such as the intake/exhaust pipe volume, the scavenging volume and the turbocharger characteristics can not be obtained.
MAP of the measured data, such as MAP of the fuel pump supply rate and the diesel engine output power from the diesel engine bench, can not be used as the input boundary the model.
The purpose of the model at running stage is to stability control the speed of three motors, but not to predict the cylinder pressure, the temperature and the flow changing process of the intake and exhaust pipe.
The model needs to be interacted with WECS and the executive mechanisms in the real time. It is possible to be interfered by the external instable factors, such as the noise signals and speed fluctuations from motors, etc.
The changed working conditions of the diesel engine have to be simulated by adjusting the load simulation device in the HIL simulation test bench.
The understanding of WECS control strategies is limited, which includes the rail pressure, the fuel injection timing and the exhaust timing.
Therefore, the objective of the simulation model is to keep the test bench safe and reliable. The simulation model at the running stage is applied with the mean value engine model (MVEM), and the ventilation process model is simplified appropriately. MVEM is commonly used for describing the diesel engine behavior, and it is based on the global energy balance of the diesel engine. The algorithm of MVEM is very simple and reliable, and its resolving cost is very low. So that it is very suitable for the real-time application.
The propulsive characteristics of the diesel engine can be used to assess its performance, so the tests of the propulsive characteristics are adopted by the manufacturer, and an "official test report" with the propulsive characteristics of the real diesel engine based on the test bench is provided to the ship-owner before delivery, which contains the mass experimental data such as the speed, the scavenging pressure, the effective fuel consumption etc. under the working condition of 25% load, 50% load, 75% load, 90% load, 100% load, 110% load. Some experimental data from the official test report are used in the simulation model.
As shown in Figure17, MVEM is improved in basis of the restrictions mentioned above. It is supposed that the exhaust loss, the heat exchange loss and the mechanism loss of 5RT-flex60C diesel engine simulated in MVEM is the same with that of 7Rt-flex60C diesel engine, which has the same cylinder diameter and the stroke of RT-flex60C diesel engine. The specific fuel oil consumption (SFOC) at the standard ambient temperature from the "Official Test Report" of 7RT-flex60C diesel engine is calculated the diesel engine effective power, and the scavenging pressure from the "Official Test Report" of 7RT-flex60C diesel engine is as the load function with the curve fitting method.
Figure 17.
Schematic diagram of the simulation model at the running stage
The definition of the model boundary in this section refers to the following. The fuel quality displacement (mm) is acquired from the injection control unit. The current crankshaft motor speed(r/min)is calculated from formula (2). The load torque adjusting coefficient is obtained from the load simulation device. The primary formulas in the improved model are as follows.
E5
(mm) is the maximum displacement of fuel piston in the maximum continuous ratings (MCR) working condition.(r/min)is crankshaft speed in MCR working condition.
Fuel injected quality per cycle
E6
(mm) is the radius of the fuel piston. (0.835kg/L) is the fuel density.\n\t\t\t\t\tis the number of cylinder. (kg) is the leak fuel quality per cycle, set as constant. The first equation in the equation (6) is used to calculate the fuel injected quality per cycle with the displacement of the fuel piston of any cylinder. And the second equation in the equation (6) is used to calculate the fuel injected quality per cycle with the displacement of fuel piston of N cylinders.
Load torque
E7
(N*m) is the load torque in MCR (maximum continuous rating) working condition. The first equation in the equation (7) is used in the condition of the load characteristic, and the second equation in the equation (7) is used in the condition of propulsion characteristics.
E8
SFOC at standard ambient temperature from the "Official Test Report" of 7RT-flex60C diesel engine SFOC of the model is calculated throughout the formula (8) with the linear interpolation method.
Output torque
E9
E10
(kW) is the effective power.
Scavenging pressure
E11
, , and are constants.
Crankshaft motor speed
E12
(kg/m)is the rotational inertia of 5RR-flex60C diesel engine.
Speeds of fuel pump motor and servo oil pump motor are calculated according to formula (3) and (4) respectively.
3.3.3. Stopping and stopping procedure
As Figure 18 is shown, the scavenging pressure is deceased to 0.01MPa in the stopping stage. The crankshaft motor speed is reduced by (r/min) gradually. The speeds of the fuel pump motor and the servo oil pump motor are calculated according to formula (3) and (4) respectively. When the crankshaft motor speed is less than 5 (r/min), all of three motors are stopped in the bound mode, but in the non-bound mode only the crankshaft motor is stopped.
Figure 18.
The control flowchart of the stopping
E13
Because the fuel pump motor has the biggest inertia moment, to keep three motors actual speed rate steady in stopping stage, is calculated from the (r/min) by the formula (13). is the different speed of the fuel pump motor in the free decelerate condition.
3.4. Exhaust valve simulation model
The exhaust valve simulation model is as the other working process simulation unit. The main functions of the exhaust valve simulation model are to provide the real-time simulated exhaust valve lift signals for WECS. The exhaust valve lift signals are triggered by the exhaust valve opening and closing pulses from FCM-20 modules. Because of the difference between HIL simulation test bench and the original machine, the exhaust valve of the test bench cannot work properly, if the load of the test bench exceeds 75%. So two approaches are designed in the exhaust valve simulation model.
If the load of the test bench is below 75% load, the lift exhaust valve signals send to WECS, are from the real exhaust valve of the test bench. The lift exhaust valve signals of the real exhaust valve are sampled and saved by the exhaust valve simulation model, when exhaust valve opening/closing order is triggered. Then, the signals collected are
Figure 19.
Schematic diagram of cylinder moving method
sent to the FCM-20 modules based on the "cylinder moving" method[13].The program flow of "cylinder moving" is shown in Figure 19. The "cylinder moving" method assumes that the working ways of all cylinders are all the same, and the working heterogeneity of the different cylinders is ignored. The working status of other cylinders is not directly calculated, but is obtained by the state recursive with the firing order. Therefore, not only the simulation speed is improved, but also the contradiction between the diesel engine\'s model accuracy and real-time is solved.
If the load of the test bench exceeds 75%, the emulator exhaust valve lift signals, simulated by the curve fitting method, are outputted by the exhaust valve simulation model. The emulator curve (mm)is simplified for a trapezoidal, which is similar to the measured curve. The emulator curve is divided into four parts, including the closing status, the opening process, the opening status and the closing process[14]. The formulas for calculating the curve are shown below:
Closing status
E14
(mm)is the displacement with minimum exhaust valve lift,.
Opening status
E15
(mm)is the displacement with maximum exhaust valve lift.
Opening process
Simulated exhaust valve lift signals are calculated according to the formula (16), when exhaust valve opening order from FCM-20 module is delayed (ms).
E16
(mm/ms)is the exhaust valve opening rate.
Closing process
Simulated exhaust valve lift signals are calculated according to formula (17), when exhaust valve closing order from FCM-20 module is delayed (ms).
E17
(mm/ms)is the exhaust valve closing rate.
According to test analysis of exhaust valve, the initial values of model parameters are shown in Table 6.
Number
Parameter
Unit
Initial value
Number
Parameter
Unit
Initial value
1
mm
0
4
mm
73
2
ms
10
5
ms
40
3
mm/ms
1.825
6
mm/ms
0.608
Table 6
Initial values of model parameters
3.5. Test verification
3.5.1. Starting process
HIL simulation test bench is started in the bound mode, and the start-up command comes from the Auto chief 20 system with the 51(r/min) setting speed. Figure 20 is shown that three motors start simultaneously and reach the setting speed at the same time in about 20 seconds. During the starting process, the three motors\' speeds increase smoothly with the setting scale factors and achieve the desired objective.
Figure 20.
The motors speed in HIL simulation bench
3.5.2. Propulsion characteristic tests
The experimental data on HIL simulation test bench, including the crankshaft speed, the scavenging air pressure, the fuel consumption, the fuel indicator, the fuel rail pressure, the servo fuel rail pressure, the exhaust valve opening and closing angle, is compared with the values from the "Official Test Report" under the typical working conditions in propulsion characteristics test. The recorded curves of the crankshaft motor speeds in 5 seconds are shown in Figure 21(a). The speeds are relatively stable with less fluctuation. The speeds contrasts with the test bench and the report are shown in Figure 21(b). The relative errors of the speed from different data source are less than 1%.
Figure 21.
Speed curves of crankshaft motor in HIL simulation bench
Figure 22 is shown the scavenging air pressure. The relative errors between the test bench and report are less than 1.5%.
Figure 22.
Data contrast curve of the scavenging air pressure
Figure 23 is shown the contrasts of the fuel consumption and fuel indicator. The relative errors of the fuel consumption are less than 1%, and the relative errors of the fuel indicator are less than 4%.
Figure 23.
Data contrast curve of the fuel consumption and fuel indicator
Figure 24 is shown the contrasts of the exhaust valve opening and closing angles. The relative errors of opening angles are less than 0.2° CA (crank angle), and the relative errors of the closing angles are less than 0.1°CA.
Figure 24.
Data contrast curve of the exhaust valve
Due to the existence of the engineering errors during diesel engine manufacturing, the performance data of the same type of low-speed marine diesel engine may be significantly different, let alone the measurement errors of the signals. Therefore, the existing errors on HIL simulation test bench are within the allowable range.
3.5.3. MCR full load shutdown test
During MCR full load shutdown test, the crankshaft motor speed is increased to the maximum instantaneous speed (), then recoveries to MCR speed after an elapsed time () with the speed regulation () according to the Formula (18).
E18
, and in MCR full load shut down test on HIL simulation test bench is compared with the values provided in "Official Test Report" in Table 7, as a result the error is very small and could be allowed.
Number
Category
/(r/min)
/s
1
Official report
120
20.6
5.3
2
Test data
119.1
18.2
4.5
Table 7
Data contrast of the MCR
3.5.4. The minimum steady speed tests
The data contrast between the test bench and report is shown in Table 8. The data contain the diesel engine speed, the fuel indicator and the load in minimum steady speed test. As a result the errors are very small and could be allowed.
Number
Category
Speed/(r/min)
Fuel indicator/(%)
Load/(%)
1
Official report
16.0
12.5
3.5
2
Test data
15.3
13.0
2.7
Table 8
Data contrast of the minimum steady speed
4. Analysis of experiment result
The fuel common-rail pressure, the injection timing, the fuel injection pulse width and the fuel-injected quantity have an great influence on the fuel spray quality and the fuel injection law. Furthermore the combustion process and emissions of the diesel engines are also suffered the impact. The fuel injection mold of RT-flex diesel engine can be divided into three types, VIT ON (variable injection timing open), VIT OFF (variable injection timing off) and HEAVY SEA (diverse sea conditions). Based on the experimental data of the typical operating points in HIL simulation test bench, the control strategies of WECS are analyzed and investigated. The focus of analysis is the strategies of the fuel common rail pressure, the injection timing of VIT ON, VIT OFF and HEAVY SEA model, the control laws of the fuel injection pulse width and the fuel injected quantity, etc.
4.1. Injection control strategies in the low load condition
As shown in Figure 28, the tests are carried on in the HIL simulation test bench to figure out the control regulations of the injector in the low load condition. 25% load of the propulsive characteristics is set as the starting experiment point. Then, the load is decreased in accordance with the propulsive characteristics, and the injecting orders of the first cylinder from the FCM-20 module are measured. The load critical point, on which the number of the working injector is fallen from 3 to 2, can be determined with the amplitude variation. Additionally the test bench is kept operating in the current state for finding out the rotation law. In the same way the load critical point can be catch, on which the number of the working injector is fallen from 2 to 1. Similarly, the load critical points in the increased process of the load also can be found. The special laws and parameters are described as follows.
Figure 25.
Testing scheme of the injection control strategy. In the decreased process of the load, the test results show that when the load is down to 7%, the average alternating interval time is 1153.6s with the number of the working injector from 3 to 2. When the load is down to 3%, there is only one injector working. And the average alternating interval times change to 1153.4s. In the increased process of the load, 10% load is the turning point of the working injector number from 1 to 2. In the 15% load, the number of the working injectors recovers to 3. And the average alternating interval times change to 1154.5s.
4.1.1. Control strategies analysis of the fuel common rail pressure
4.1.2.1. Starting process
In the start-up phase, the common rail pressure is quickly established. In order to achieve the rapidity and stability, the open-loop control strategy is applied in WECS. The experimental curves of the fuel common rail pressure and control signals are shown in Figure 26. To ensure the maximum fuel delivery, the fuel pump control signal is kept with the 20 mA at the beginning, then the fuel pressure increases gradually with maintained control signal. When the actual pressures get to 25MPa, the control signal reduces to 7mA. While the actual pressures rise to the 60MPa, the control mode is translated into the PID (Proportion Integration Differentiation) closed-loop control state. To void pressure fluctuations, the current control signal is regarded as the initial value in the transition process.
Figure 26.
Curves of the fuel pressure and control signals
4.1.2.2. Running process
The actual common rail pressures have to follow the target pressures at the engine working, so the closed-loop feedback control algorithm is used for the fuel rail pressure control. At the VIT ON and VIT OFF injection modes, the closed-loop control algorithm is used by WECS, and it is shown in Figure 27. The target pressures are get by looking up the rail pressure MAP chart according to the diesel engine load, and PID feedback control algorithm is carried out based on the difference value between the actual and the target pressures. What’s more, the feed forward control is used to improve the system response performance.
Figure 27.
Closed-loop control algorithm
The actual pressure is unavoidable fluctuate in the fuel injection process. Also the pressure signals may be disturbed susceptibly. Therefore the signals need to be filtered to avoid the sharp pressure fluctuations caused by the mutations of control current signals. In addition, the target pressure may fluctuate wildly with the load changing when the diesel engine is working at the transient transition conditions. PID closed-loop control algorithm may result in a longer transition time of the actual rail pressure, which will impact on the fuel injecting and combusting. The feed forward control is added to the control algorithm to improve the response of the control system, and the feed forward control MAP of the common rail pressure is looked up via the fuel instruction. At VIT ON and VIT OFF injection modes, in the low load range of 0 to 15%, the target pressure value is 70MPa. In the load range of 15% to 25%, the target pressure value decreases to 60MPa. In the load range of 25% to 77%, the target value maintains 60MPa. In the load range of 77% to 90%, the target value gradually increases to 90MPa. In the load range more than 90%, the target value maintains 90MPa, and the feed forward control current signals is increased with the fuel indicate at the same percentage.
When the fuel injection mode is VIT ON or VIT OFF, the control strategies of the fuel common rail pressure prefer to reduce emissions at below 77% load, while prefer to improve the fuel economy when the load is more than 77% load. When the diesel engine load is less than 15% load, WECS will cut off parts of the injectors. Taking account of both the fuel economy and the emissions, the target value of the fuel common rail pressure is set as 70MPa. Since it can improve the combustion heat release rate, but not cause the NOX substantial increase. At the HEAVY SEA mode, PID closed-loop control algorithm is still active, but the target value of common rail pressure maintains 70MPa under various loads. The purpose is to avoid the actual pressure sharp fluctuation resulting in the mechanical components damaged.
4.1.2. Control strategies analysis of injection timing
The adjustment parameters of the injection timing angle will be freely set within a certain range by WECS according to the different fuel quality and the balance condition of each cylinder in the whole working situation. At VIT ON mode, in order to achieve optimal balance between economy and emissions of diesel engines, WECS adjusts the injection timing angle according to the scavenging pressure, the diesel engine speed and the change of the fuel common rail pressure. Variable injection timing angle is calculated as follows:
E19
(19)
The parameter is set as the standard angle of the fuel injection timing, and the default value is 2 ° CA. The parameter is used for adjusting the imbalance working condition of each cylinder, caused by the tolerances of the manufacturing and the turbocharger matching. The parameter is also the compensation of the fuel injection timing, which can be adjusted according to the fuel quality. If heavy oil is used, it will change the combustion lagging period of the diesel engine, then cause the cylinder pressure deviations in combustion process. The adjustment values of three injection timing mentioned above are set by user based on actual conditions. It will not change with the load in the operation process of the diesel engine. At VIT OFF and HEAVY SEA mode, the injection timing angle is the sum of three adjusted values.
At the VIT ON mode, , and will be involved in the calculation of the variable injection timing angles. The parameter is the fuel injection timing angle, which will be adjusted sectionally based on the scavenging pressure. When the scavenging pressure is lower than 0.35bar, the value is set to 0. It is due to the low load of the diesel engine, and the auxiliary fan with the turbocharger does not work right now, so there is little significance to adjust the injection timing angle. When the scavenging pressure gradually increases from 0.35bar to 0.85bar, the value of should gradually reduce from 0°CA to -2.5°CA. Since the ahead of the injection timing angle is benefited to improve the fuel economy at the low scavenging pressure. When the scavenging pressure continues rising to 0.85bar, the value of should gradually rise from -2.5°CA to 1°CA. Since increased compression pressure and the delayed injection timing angle help to reduce NOX emissions with the low combustion temperature.
The parameter is used to adjust injection timing angle according to the diesel engine speed. When the diesel engine load is the constant, the lower average effective pressure caused by the high speed results in the reduce of the combustion pressure. When the diesel engine speed is in the region of 70% to 100%, the value of reduces gradually from 3°CA to -1°CA.
The parameter is used to adjust the injection timing angle according to the fuel common rail pressure. The lower of the fuel common rail pressure would cause longer injection time and poor fuel atomization. The advancement of fuel injection timing angle through is in favor of promoting combustion in order to improve the fuel economy of the diesel engine. When the fuel rail pressure increases gradually and exceeds the operating point pressure of MCR, the delay of fuel injection timing angle will compensate for the increased NOX emissions caused by too high fuel injection pressure via the.
4.1.3. The main conclusions
If the load of diesel engine gradually reduces from high load to 7% or 3%, the number of the actual working injectors of each cylinder will reduce from three to two or one. If the load of diesel engine gradually rises from low load to 10% or 15%, the number of the actual working injectors of each cylinder will increase from one to two or three. The average alternating times of the injectors are approximate 1154s.
At VIT ON and VIT OFF mode, the control strategies of the fuel common rail pressure prefer to reducing emissions at the load below 77%. The control strategies prefer to improve the fuel economy when the load rises to more than 77%. WECS will cut off some of the injectors when the diesel engine load is less than 15% load. Taking account of both the fuel economy and the emissions, the target value of the fuel common rail pressure is set to 70MPa, and the objects are to improve the combustion heat release rate and avoid NOX increasing. The fuel injection mode of HEAVY SEA is set to prevent the mutations of the diesel engine load caused by adverse sea conditions. At the HEAVY SEA mode, the pressure of each load maintains 70MPa, and the PID closed-loop control algorithm is still used by WECS. Because the rough sea conditions could lead to the actual rail pressure sharp fluctuation resulting in the mechanical components damaged.
At VIT ON mode, when the diesel engine is working in low load working condition, fuel injection control strategies of WECS prefer to reducing emissions by taking a delay of injection timing angle. When the diesel engine is working in 75% load working condition, the engine speed is 90% of MCR speed, which is the commonly working condition of the actual operation of the marine diesel engine. Therefore, if the diesel engine is working at the 75% load or nearby, the fuel injection timing angle is set to advance to improve the fuel economy in priority.
4.2. Control strategies and characteristics of the exhaust valve system
4.2.1. Characteristics of the exhaust valve
The duration opening angles of the exhaust valve in difference working condition of the diesel engine are obtained in the test bench, which are calculated by the different angle between the corresponding angle at 15% full lift of the exhaust valve opening and the one at 85% full lift of the exhaust valve closing according to the experimental data. The duration opening angle increases along with the engine load. The open degree of the servo oil pump is taken to regulate the servo oil common rail pressure. And the open degree is controlled by the duty cycle of PWM (Pulse-Width Modulation) from WECS.
The delay times and angles of the exhaust valve opening are compared with the test data under different operating conditions. There is a hydraulic mechanism delay from the opening signal sending to the exhaust valve moving. When the exhaust valve is turned on, the spring is hit by the stem to produce the rebound from the spring. Along with the increase of the diesel engine load, the common rail pressure increases, but the delay time of the exhaust valve opening reduces. If the crank angle is set as the abscissa, the delay angle of the exhaust valve opening becomes large with the increase of the engine speed.
The delay times and the angles of the exhaust valve closing are compared with different operating conditions from the test data. There is a delay between the closing signal of the exhaust valve sent by ECU and the exhaust valve closing fully. The air spring pushes the exhaust valve until closed, and the delay time of the exhaust valve doesn’t change significantly, but the speed and the time of delaying angle of the exhaust valve closing increase along with the working load. Therefore, the opening and closing of the exhaust valve are related to not only the system characteristics, but also the working conditions of the diesel engine.
4.2.2. The main conclusion
The setting angles of the exhaust valve opening and closing are confirmed by WECS based on the working condition of the diesel engine. The angles of the exhaust valve opening and closing are calculated through the measured lift curve of the exhaust valve. The control signals phase is adjusted by the difference between the setting value and the calculated one. The closed-loop control is used to make the exhaust valves opening / closing at a specified angle.
Some characteristics of control strategies of the exhaust valve are listed as follows[15]:
Servo oil common rail pressure rises together with the increasing of the working load of diesel engine.
The corresponding angle of the opening control signal of the exhaust valve reduces with the increasing of the working load of diesel engine.
The corresponding angle of the closing control signal of the exhaust valve tends to increase with the working load of the diesel increases from 25% load to 75% load, and then the angle descends.
The angle difference between the exhaust valve opening and closing increases with the working load of the diesel increasing from 25% load to 75% load, and then the angle descends.
The corresponding angle of the 15% full lift of the exhaust valve opening drops with the increasing of the working load of the diesel engine.
The corresponding angle of the 85% full lift of the exhaust valve closing increases with the working load from 25% to 75%, and the delay angle of the exhaust valve closing becomes large. So the corresponding angle is amended by WECS through reducing the control signal angle.
The different corresponding angles between the 15% full lift of the exhaust valve opening and the 85% full lift of the exhaust valve closing generally increase with the increasing of the working load of the diesel engine.
5. Conclusion
Hardware-in-loop simulation test bench of the HPCR electronic control system for low-speed marine diesel engine is developed basing on the Wärtsilä marine diesel engine. The working characteristics of the fuel injection system and the exhaust valve, and the control strategies under difference injection model are analyzed by the method of the experimental research together with simulation analysis. The main conclusions are listed as follows:
Typical structural and functional characteristics of two type low-speed intelligent marine diesel engine are analyzed. HPCR system of RT-flex marine diesel engine is the hydraulic-mechanical system which functions are independent but structure is inseparable from each other. The system is consisted of the oil supply unit, the common-rail unit, the fuel injection control unit, the exhaust control unit and so on. WECS is the control center of the HPCR system. The control signals and the rail pressure regulator signals from WECS impact on the working process and the state of the HPCR system directly. The common rail unit of ME marine diesel engine adopts the form of a single-cylinder assembled with a fuel supercharger. With the help of the servo oil pressure, NC valve can conduct the fuel injection with the various injection laws. The combustion process under difference working conditions is improved. The reduced fuel consumption and emissions will be achieved.
HIL simulation test bench is developed on the base of the analysis of the HPCR electronic control system of 5RT-flex60c marine diesel engine. The test bench contains the real time simulation model of the diesel engine unit and the monitoring system. The experiment results are shown that: The working characteristics of the HPCR system is in conformity with that of the original machine, and WECS control strategies are reflected distinctly in the test bench. The experimental conditions are provided for the research on the system characteristics, the control strategies and the performance of HPCR of high-power marine diesel engine.
Different typical working conditions of the propulsive characteristics of the diesel engine are simulated throughout the HIL test bench. The feature data of HPCR electronic control system are obtained, including the fuel pressure, the needle lift, the control pulse signals of the fuel injection, the exhaust valve opening and closing signals and the exhaust valve lifts and so on. Based on the experimental data, the investigations into control strategies of WECS, the characteristic feature of the fuel injection unit and exhaust valve control unit are focused on.
\n',keywords:null,chapterPDFUrl:"https://cdn.intechopen.com/pdfs/44433.pdf",chapterXML:"https://mts.intechopen.com/source/xml/44433.xml",downloadPdfUrl:"/chapter/pdf-download/44433",previewPdfUrl:"/chapter/pdf-preview/44433",totalDownloads:5204,totalViews:499,totalCrossrefCites:2,totalDimensionsCites:2,totalAltmetricsMentions:0,impactScore:1,impactScorePercentile:54,impactScoreQuartile:3,hasAltmetrics:0,dateSubmitted:"November 2nd 2011",dateReviewed:"October 11th 2012",datePrePublished:null,datePublished:"April 30th 2013",dateFinished:"April 29th 2013",readingETA:"0",abstract:null,reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/44433",risUrl:"/chapter/ris/44433",book:{id:"2432",slug:"diesel-engine-combustion-emissions-and-condition-monitoring"},signatures:"Jianguo Yang and Qinpeng Wang",authors:[{id:"138743",title:"Prof.",name:"Jianguo",middleName:null,surname:"Yang",fullName:"Jianguo Yang",slug:"jianguo-yang",email:"jgyang@whut.edu.cn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"141905",title:"Dr.",name:"Qinpeng",middleName:null,surname:"Wang",fullName:"Qinpeng Wang",slug:"qinpeng-wang",email:"wangqpkevin@163.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_1_2",title:"1.1. Energy crisis and emission regulations ",level:"2"},{id:"sec_2_2",title:"1.2. Hardware-in-loop simulation technology",level:"2"},{id:"sec_4",title:"2. HPCR electronic control system of low-speed marine diesel engine",level:"1"},{id:"sec_4_2",title:"2.1. Introduction",level:"2"},{id:"sec_5_2",title:"2.2. RT-flex type marine diesel engine",level:"2"},{id:"sec_5_3",title:"2.2.1. Oil supply unit",level:"3"},{id:"sec_6_3",title:"2.2.2. Common rail unit",level:"3"},{id:"sec_7_3",title:"2.2.3. Injection control unit",level:"3"},{id:"sec_8_3",title:"2.2.4. Exhaust control unit",level:"3"},{id:"sec_9_3",title:"Table 2",level:"3"},{id:"sec_11_2",title:"2.3. ME type marine diesel engine",level:"2"},{id:"sec_11_3",title:"2.3.1. Injection control unit",level:"3"},{id:"sec_12_3",title:"2.3.2. ECU of ME diesel engine",level:"3"},{id:"sec_14_2",title:"2.4. Comparative analysis between RT-Flex and ME ",level:"2"},{id:"sec_14_3",title:"2.4.1. Similar points",level:"3"},{id:"sec_15_3",title:"2.4.2. Dissimilar points",level:"3"},{id:"sec_18",title:"3. Development of HIL simulation tested bench of HPCR electronic control system",level:"1"},{id:"sec_18_2",title:"3.1. Design of HIL simulation test bench of HPCR electronic control system",level:"2"},{id:"sec_18_3",title:"Table 3",level:"3"},{id:"sec_19_3",title:"3.1.2. Functions of HIL simulation test bench",level:"3"},{id:"sec_21_2",title:"3.2. Executive mechanisms of HIL simulation test bench",level:"2"},{id:"sec_22_2",title:"3.3. Real-time diesel engine simulation model ",level:"2"},{id:"sec_22_3",title:"Table 5",level:"3"},{id:"sec_23_3",title:"3.3.2. Running stage",level:"3"},{id:"sec_24_3",title:"3.3.3. Stopping and stopping procedure",level:"3"},{id:"sec_26_2",title:"3.4. Exhaust valve simulation model",level:"2"},{id:"sec_27_2",title:"3.5. Test verification",level:"2"},{id:"sec_27_3",title:"3.5.1. Starting process",level:"3"},{id:"sec_28_3",title:"3.5.2. Propulsion characteristic tests",level:"3"},{id:"sec_29_3",title:"Table 7",level:"3"},{id:"sec_30_3",title:"Table 8",level:"3"},{id:"sec_33",title:"4. Analysis of experiment result",level:"1"},{id:"sec_33_2",title:"4.1. Injection control strategies in the low load condition",level:"2"},{id:"sec_33_3",title:"4.1.1. Control strategies analysis of the fuel common rail pressure",level:"3"},{id:"sec_34_3",title:"4.1.2. Control strategies analysis of injection timing",level:"3"},{id:"sec_35_3",title:"4.1.3. The main conclusions",level:"3"},{id:"sec_37_2",title:"4.2. Control strategies and characteristics of the exhaust valve system",level:"2"},{id:"sec_37_3",title:"4.2.1. Characteristics of the exhaust valve",level:"3"},{id:"sec_38_3",title:"4.2.2. The main conclusion",level:"3"},{id:"sec_41",title:"5. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'PintoF. R. P.Vega-lealA. P.2010A Test of HIL COTS Technology for Fuel Cell Systems Emulation. 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J.034952\n\t\t\t'},{id:"B10",body:'Zhiang WangJianguo Yang (2004Analysis of Electronically-controlled Fuel System of MAN and Sulezer Diesel Engine. Diesel Engine. J. supplement:1922\n\t\t\t'},{id:"B11",body:'Zheng WangJianguo Yang, Wei Zhang (2010Design and Implementation of HIL Simulation Test Platform of HPCR System for Intelligent Large Low Speed Diesel Engine.Chinese Internal Combustion Engine Engineering. J.065458'},{id:"B12",body:'Zheng WangJianguo Yang (2010Method study for RT-flex HPCR low-speed diesel engine injecting law measuring.International Conference on Mechanical and Electrical Technology2010Singapore. C'},{id:"B13",body:'Qinpeng WangXujing Tang, Zheng Wang, Chang Shu, Yonghua YU, Jianguo Yang (2009ECU hardware in-loop simulation design for common rail system of diesel engine based on cRIO controller. Ship Engineering. J.051316\n\t\t\t'},{id:"B14",body:'Qinpeng Wang (2009The Design of Monitoring Control System with Heavy Duty Low-speed Diesel Engine. Wuhan University of Technology. D'},{id:"B15",body:'Jianguo YangChang Shu, Qinpeng Wang (2012Experimental research on exhaust valves based on a hardware-in-loop simulation system for a marine intelligence diesel engine. Journal of Harbin Engineering University. J.0217\n\t\t\t'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Jianguo Yang",address:null,affiliation:'
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1. Incidence and etiology of plantar fasciitis
About 7% of the population >65 years suffer from a painful heel, even though younger people are often affected, too [1]. The most common cause of this symptom is the so‐called “plantar fasciitis” [2]. This term is widely used, although “plantar fasciopathy” or “plantar fasciosis” would be a better description to point out the degenerative nature of the disease. However, as more than 1100 citations in Pubmed quote “plantar fasciitis” (in comparison with only 50), we will use the traditional term in the following.
Plantar fasciitis has been associated with obesity, with acute or chronic work overload, or with work on hard surfaces [2, 3]. It seems that physiological degeneration of the fascia at the calcaneal insertion exacerbates due to repetitive microtraumas caused by vertical compression [4]. This causes inflammatory tissue reactions. As a result, the fascia is thickened with an associated fluid collection to 4.0 mm and more in ultrasonography [5]. Furthermore, this inflammation may trigger bone formation, the so‐called “plantar heel spur.” This process has been studied intensively by Kumai and Benjamin [6]. They proposed three stages of spur growth: “(a) an initial formation of cartilage cell clusters and fissures at the plantar fascia enthesis; (b) thickening of the subchondral bone plate at the enthesis as small spurs form; and (c) development of vertically oriented trabeculae buttressing the proximal end of larger spurs” [6]. The first description of this spur formation and correlation with the clinical symptoms was carried out by Plettner in 1900 [7]. However, not every heel spur is associated with heel pain, as these spurs are found in 11–16% of the normal asymptomatic population [4]. On the other hand, some patients with painful plantar fasciitis do not have a radiographic confirmation of a spur formation.
A similar mechanism (although caused by longitudinal traction and not by vertical compression) of bone formation has been described at the insertion of the Achilles tendon [8].
According to the American clinical practice guidelines from 2010, diagnosis is established by the typical anamnesis and the characteristic localizations of tenderness. Still, weight‐bearing radiographs are also recommended [9].
2. Treatment with LD‐EBRT
2.1. Biological effects of LD‐EBRT on lymphocytes and inflammatory processes
Single doses of external beam radiotherapy (EBRT) in the range of 0.3–1 Gy are called “low dose EBRT” (LD‐EBRT). These single fractions are applied two or three times a week until a total dose of about 3–6 Gy is reached. Such radiotherapeutic concepts are used for diverse nonmalignant conditions, e.g., osteoarthrosis, tendinopathy, epicondylitis, or bursitis. A comprehensive review of the historical developments in LD‐EBRT for benign diseases is given by Trott [10].
In contrast, EBRT in oncology is characterized by much higher single and total doses. “Normofractionation” describes single doses of 1.8–2 Gy, applied about five times a week. To treat breast cancer, the total doses of about 62 Gy are necessary, in prostate cancer even more than 72 Gy. From a radiobiological point of view, these high cumulative doses are used to induce DNA double strand breaks. Due to errors in a repair mechanism (nonhomologous end joining), dicentric chromosomes can occur. These can result in unfinished mitoses, the so‐called “mitotic catastrophe,” the main mechanism to reduce clonogenic survival in tumor cells [11]. High doses of EBRT induce local inflammation and tissue reactions.
The much lower doses of LD‐EBRT act via different mechanisms. In the last two decades, several anti‐inflammatory effects have been discovered, contrary to the effects of the above‐mentioned high EBRT doses.
In vitro LD‐EBRT has been shown to induce apoptosis in peripheral blood mononuclear cells (PBMC) [12]. Interestingly, there was not a linear correlation between dose and the amount of apoptotic cells. Instead, the maximal induction of apoptosis was observed after a single dose between 0.3 and 0.7 Gy, higher doses (up to 3 Gy) not being more effective [12].
Furthermore, doses between 0.1 and 0.5 Gy reduced the adhesion of PBMC significantly to endothelial cells (ECs) in vitro, probably by suppressing the expression of L‐selectin on the surface of PBMC [13]. This is a very important finding, as the adhesion of leukocytes to the cells of the vessel wall is the first event of tissue invasion in inflammatory processes [13]. An-other reason for the reduced adhesion between PBMC and EC was identified by Rödel et al. [14]: In irradiated EC mRNA expression and protein secretion of transforming growth factor β1 (TGF‐β1) were highest after 0.5 Gy, higher doses resulted in a decline to basal levels [14]. Neutralization TGF‐β1 with specific antibodies restored the adhesion between PBMC and EC. These in vitro results were confirmed in vivo in a mouse model for 0.3 Gy [15]. TGF‐β expression is dependent on activation of the nuclear factor‐kappa B (NF‐κB) [16]. Also, NF‐kB DNA‐binding activity showed a biphasic response to LD‐EBRT with a first maximum at 0.5 Gy, a relative minimum between 0.6 and 0.8 Gy, and a second increase at 1 and 3 Gy [16]. The above‐mentioned findings show a biphasic time course with reduced adhesion of PBMC 4 and 24 h after LD‐EBRT, with a relative maximum of adhesion after 12h [17].
A third mechanism was the suppression of nitric oxide (NO) production in activated macrophages by LD‐EBRT between 0.3 and 1.25 Gy [18]. As the expression of inducible nitric oxide synthases (iNOS) proteins was not altered, the LD‐EBRT seemed to act at the translational or posttranslational level. Furthermore, a dose of 0.5 Gy significantly reduced oxidative burst and superoxide production of stimulated macrophages [19]. A diminished release of reactive oxygen species (ROS) can also contribute to the anti‐inflammatory effects of LD‐EBRT.
Taken together, all of these pathways and mechanisms showed a similar dose dependence with a maximum effect between 0.3 and 0.7 Gy regarding a discontinuous dose‐effect relation [20].
There are several in vivo studies in different animal models about the effects of LD‐EBRT, especially on osteoarthritis. A comprehensive overview is given in Ref. [20], however, as they are not directly related to calcaneodynia, we will not further comment on them.
2.2. Results of randomized trials on radiotherapy for painful heel spur
Since 1937 [21] for decades, large retrospective studies on the efficacy of LD‐EBRT in calcaneodynia have been published (overview in 22). In 1970, one negative randomized trial was reported and heavily criticized but had not been repeated [23]. Starting in the 1980s, patients were systematically clinically examined and interrogated in a structured manner to try to control for diverse risk factors and to compare the efficacy of different fractionation schemes and total doses [24].
It took until the past decade to perform and report prospectively randomized trials to proof the efficacy of LD‐EBRT and to identify the optimal dose fractionation schedule. In the following, we report the design and the results of these trials. Table 1 gives a short overview of the studied dose concepts and the results. Due to methodological reasons, we will describe the studies not following their publications dates, but according to a systematic order.
2.2.1. Clinical proof of the efficacy of LD-EBRT
Since the publication of the first randomized trial on LD-EBRT in 1970, the efficacy of LD‐EBRT was questioned [23]. Goldie et al. randomized 399 patients, however, only nine patients suffered from calcaneodynia. This is why these results cannot be extrapolated to LD‐EBRT of a painful heel spur. Furthermore, endpoints were not clearly defined, and therapy was started in an acute stage of the disease [25].
The landmark study to prove the efficacy of LD‐EBRT was performed by the German cooperative group on the radiotherapy for benign diseases (GCGBD) under the responsibility of Niewald et al. [26]. A very low dose EBRT (6 × 0.1 Gy applied twice a week up to a total dose of 0.6 Gy) was randomized to a standard dose LD‐EBRT (6 × 1 Gy twice a week up to a total dose of 6 Gy). In the case of an unfavorable response after 3 months, the patient was offered a second treatment series (“reirradiation”) applying a standard dose. The dosage of the experimental arm was chosen to examine if very low doses are effective at all. Second, it acted as a placebo irradiation, as a sham irradiation was regarded unethical. LD‐EBRT was applied using a linear accelerator (4‐ to 6‐MV photons) using lateral parallel opposing fields.
Inclusion criteria were tenderness of the calcaneus with a limitation of the painless walking distance and duration of the symptoms for more than 6 months. Furthermore, a radiological proof of a heel spur was required, and the patients had to be least 40 years of age. Patients with previous traumata to the foot, rheumatic or vascular diseases, lymphatic edema, pregnancy, or breastfeeding were excluded. Concomitant therapy with oral analgesics was not limited. However, local injections with steroids during the study period were not permitted.
Initially, 200 patients were planned [27] to detect a difference of 10% in the quality of life (QOL) sum score (SF‐12) [28] and calcaneodynia sum score (CS) [29] (Table 2) with a power of 80% and an error probability of 5%. Furthermore, the visual analogue scale (VAS) to evaluate pain intensity was used. However, after randomization of 66 patients and interim analysis of 62 patients (4 had to be excluded due to a withdrawal of informed consent or violation of the inclusion criteria), the differences in efficacy between the two treatment arms were so pronounced, that the trial was closed early.
Author
Year
N
Standard arm
Experimental arm
Results
Conclusions
Niewald et al. [26]
2012
66
6 × 1 Gy twice a week
6 × 0.1 Gy
3 months: VAS/CS/SF12 sig. better with standard
1. Dose‐response relationship
1 year: less second treatment series with standard
2. Proof of therapeutic effect of LD‐EBRT
Heyd et al. [30]
2007
130
6 × 1 Gy twice a week
6 × 0.5 Gy
6 months: CS no sig. differences
6 × 0.5 Gy as standard fractionation
Ott et al. [32]
2014
457
6 × 1 Gy twice a week
6 × 0.5 Gy
6 weeks, 2.5 years: VAS/CS no sig. differences
6 × 0.5 Gy as standard confirmed
Niewald et al. [25]
2015
127
6 × 1 Gy twice a week
12 × 0.5 Gy thrice a week
3 months: VAS/CS/SF12 no sig. differences
Efficacy not increased with 12 × 0.5 Gy standard still 6 × 0.5 Gy
Table 1.
Summary of contemporary randomized trials on LD‐EBRT of painful heel spurs: tested schedules, results, and conclusions.
Criteria
Extent of symptoms/alteration
Points
1. Pain symptoms
S = Pain at strain
6 / 4 / 2 / 0
(total: 30%)
N = Pain during night time D = Pain during day time (continuously) R = Pain at rest (following any kind of strain) I = Pain at initiation of movement/morning stiffness none = 6 ; slight = 4 ; moderate = 2 ; severe = 0 points ⇨
None Orthopedic shoe, insoles, heel cushion One cane or crutch Two canes or crutches ⇨
15 10 5 0
3. Professional activities (total: 20%)
No limitation, maximum professional strain possible Slight limitation, normal professional work possible Moderate limitation, reduced professional activity Severe limitation, daily professional work impossible ⇨
20 10 5 0
4. Daily/leisure activities (total: 15%)
No limitation of daily and leisure activities and sports Slightly limitation/reduced leisure activities and sports Moderate limitation/no leisure activities and sports Complete limitation of any daily and leisure activities ⇨
15 10 5 0
5. Gait/limp (total: 20%)
No limp, normal walking is possible without a limitation Slightly altered, limp after walking > 1 km (2 blocks) Moderately altered, limp after walking < 1 km (2 blocks) Severely altered, normal walking is impossible ⇨
20 10 5 0
Total score
Sum of the single scores 1 + 2 + 3 + 4 + 5 ⇨
Table 2.
Calcaneodynia score of the GCG‐BD [29], based on [31].
The mean age of patients was 54 years in the standard dose group and 58 years in the 6 × 0.1 Gy group. Sixty‐one patients had a plantar, one patient a dorsal heel spur. In mean, patients in the standard dose group suffered for 15.3 months before the start of LD‐EBRT, in the 6 × 0.1 Gy group for 18.8 months. Twenty‐one patients had symptoms on both sides. In 28 patients the pain irradiated into the calf, only in 18 patients it was localized to the sole of the foot. Two patients had received surgery for LD‐EBRT.
Three months after therapy VAS values, CS‐ and QOL‐scores were significantly better after the standard dose in comparison with the very low dose treatment arm. The higher pain relief resulted in a better QOL. Twelve months after therapy about 64% of the patients after 6 × 0.1 Gy had to receive a second treatment series due to insufficient treatment results, in comparison with only 17% of the patients in the standard dose treatment group. As the second series was applied with a standard dose (6 × 1 Gy), patients in the 6 × 0.1 Gy group who were reirradiated showed equally favorable results compared with those in the standard‐dose group who did not receive a second course [26]. This is why the second treatment series in this clinical setting acted as a “salvage therapy.” Another interesting finding was that patients with a good response already at 3 months remained stable or even improved at 12 months. Furthermore, this underlines the long‐lasting efficacy of LD‐EBRT.
Acute side effects or long‐term toxicity did not occur.
In conclusion, this randomized trial established a dose‐response‐relationship of the analgesic effect of LD‐EBRT, thus providing a clinical and methodological proof of the efficacy of 6 × 1 Gy LD‐EBRT on the clinical course of painful heel spurs. The early termination of the study was justified due the interim analysis showing significant differences in the clinical outcome between both treatment arms. Still, the trial was not blinded, so both the patients and the staff were aware of the received dose. With modern linear accelerators, a complete blinding of the staff is nearly impossible. The only option would be a shame irradiation with closed collimator jaws, reducing the dose to the unavoidable “leakage” radiation. A much easier and straight forward way was used in the above‐mentioned study by application of a minimal physical dose with 0.1 Gy. Another critical point might be that only half of the patients were examined 12 months after therapy (n = 36). This reduces the reliability of the study results at this time point. However, this does not affect the results concerning treatment efficacy 3 months after LD‐EBRT.
Another potential confounder not only in this study but also in all other published prospective and retrospective case series might be that a lot of the patients had received diverse and other conservative therapies before being referred to LD‐EBRT. An interaction between one of these other treatments and LD‐EBRT cannot be ruled out due to methodological reasons. This reflects clinical reality. Still, an interaction between one of these therapies and LD‐EBRT is rather unlikely and counter‐intuitive, as patients were referred to LD‐EBRT after the clinical failure of all the other conservative treatments.
2.2.2. Looking for the minimum effective dose: optimization of fractionation and total dose of LD-EBRT
2.2.2.1. Single dose 0.5 vs. 1 Gy
Two randomized studies investigated the efficacy of 0.5 Gy single dose in comparison to 1 Gy.
The first trial was conducted by Heyd et al. [30]. They randomized 130 patients between 6 × 0.5 Gy twice weekly (low dose) and 6 × 1 Gy (standard dose). A linear accelerator was used, applying a single field technique.
Inclusion criteria were clinical signs of a painful heel spur, radiological evidence of spur formation, patient age ≥30 years and a relapse after previous conservative treatments, in patients >45 years LD‐EBRT could be used as the primary treatment. Endpoints of the study were changes in the “original” calcaneodynia score [31], that was documented before LD‐EBRT, at the end of the course, and 6 weeks and 6 months afterward.
One hundred and thirty patients were randomized. Mean age was 58.4 years. A 102 patients suffered from a plantar, one patient from a dorsal, and 27 patients from combined spurs. In mean, patients had been suffering from symptoms for 9.8 months. The symptoms had been present in 58 patients for less than 6 months, in 72 patients for a longer time. In 7 heels LD‐EBRT was the first therapeutic approach.
At the end of LD‐EBRT, 66% in the low dose group vs. 59% in the standard dose experienced an improvement in symptoms, 6 weeks later 80 vs. 85%. At this time point, 1.5% in each group reported an increase in symptoms, 19 vs. 14% no change. No statistically significant differences were noted. In case of insufficient treatment results patients were offered a second EBRT series. Thus 26 vs. 37% were treated a second time. Six weeks after that, 71 vs. 79% of these patients reported a further improvement. Six months after LD‐EBRT 88% of the patients in both groups had an amelioration of their symptoms, the remaining patients reported no change. During the EBRT series a slight increase in pain was reported by 26 vs. 29% of the patients. No other acute or late toxicity occurred.
In conclusion, 6 × 0.5 Gy twice weekly was as effective as 6 × 1 Gy.
These results were confirmed by a second randomized trial [32, 33]. Ott et al. randomized 457 patients between 6 × 0.5 Gy (low dose) and 6 × 1 Gy (standard dose). In contrast to the above‐cited “Heyd‐study” [30] an X‐ray unit (orthovoltage) and not linear accelerators was used. Patients received a single field (6 × 8 cm on the plantar calcaneus) with 150 kV, 15 mA, 1 mm Cu‐filter, with source‐to‐skin distance (SSD) of 40 cm. Six weeks after the LD‐EBRT a second series was offered to patients with an insufficient response. The endpoint was pain reduction. CS score and VAS values were measured before and at the end of LD‐EBRT (early response), 6 weeks (delayed), and 2.5 years (long‐term) afterward.
With a median follow‐up of 32 months the mean VAS values before treatment, for early, delayed, and long‐term response for the 0.5 and 1.0 Gy groups were 65.5 ± 22.1 and 64.0 ± 20.5 (p = 0.19), 34.8 ± 24.7 and 39.0 ± 26.3 (p =0.12), 25.1 ± 26.8 and 28.9 ± 26.8 (p =0.16), and 16.3 ± 24.3 and 14.1 ± 19.7 ( p =0.68) [31]. Similar results were obtained for the CS score without any significant differences between both dose groups.
Taken together, the above‐mentioned studies proofed an equivalent clinical efficacy of 6 × 0.5 Gy in comparison to 6 × 1 Gy, thus defining a new clinical treatment standard with six times 0.5 Gy twice weekly as the minimum effective dose.
Before proofing 0.5 Gy as the new standard single dose, another randomized study tried to increase efficacy in reaching the “old” cumulative dose of 6 Gy with a single dose of 0.5 Gy. Niewald et al. randomized between 6 × 1 Gy twice a week (old “standard dose”) and 12 × 0.5 Gy three times a week (“experimental dose”) [25]. The aim was not just to get comparable results, but to further improve the analgesic effects. Linear accelerators (6 MV photons) applying a lateral opposing field technique were used.
Inclusion and exclusion criteria were quite similar to the ones used in the landmark study [26]: Clinical evidence of a painful heel spur, and duration of the symptoms for more than 6 months; radiological proof of a spur formation; age at least 40 years; Karnofsky‐Index at least 70%. Patients with previous radiotherapy or previous trauma to the foot, rheumatic or vascular diseases, lymphatic edema, pregnancy, breastfeeding, or severe psychiatric disorders were excluded. Concomitant therapy with analgesics was allowed. However, patients receiving surgery or shock wave therapy after randomization were excluded.
Endpoints were the SF‐12 sum score, the CS sum score (Table 2), and VAS. Follow‐up was scheduled every 6 weeks for 1 year.
Two‐hundred and forty patients were calculated to detect a difference of 15% in the VAS and CS score, with a power of 80%, and an error probability of 5%. After randomization of 127 patients and an interim analysis of 107 patients, the study was closed early, as the intended increase in analgesic efficacy by the experimental treatment was very unlikely to be achieved.
The mean age of the patients in the standard group was 56.1 Gy in comparison with 58.1 Gy in the experimental group. The mean duration of symptoms before initiation of LD‐EBRT was 17 vs. 16 months. In 98% of the standard group and 93% of the experimental group a plantar spur was treated, in 2 and 7% a combined (plantar and dorsal) spur.
Results after 3 months have been issued so far [25], longer follow‐up has yet to be published. After 3 months, there were no significant differences neither in the VAS (standard 42.3 vs. experimental 44.4) nor the CS sum score (28 vs. 28.4) nor in the QOL (SF‐12) scores. Although longer follow‐up has to be awaited, a further increase in the analgesic effect by applying 12 × 0.5 Gy three times a week is unlikely. This is why this fractionation schedule is currently not recommended, as it does not follow the “as low as reasonable achievable” principle of radiation protection.
2.2.2.2. Single dose 0.3 vs. 1 Gy
Further reduced single doses in LD‐EBRT (with the exception of 0.1 Gy [26]) have never been tested in a prospectively randomized clinical trial. In radiotherapy of degenerative joint disorders, single doses of about 0.3–0.4 Gy were established by von Pannewitz in the late 1920s and published in 1933 and 1970 [34, 35]. However, two studies on calcaneodynia have raised serious concerns on single doses as low as 0.3 Gy.
Seegenschmiedt et al. analyzed treatment efficacy in 141 patients (170 irradiated heels), who were treated from 1984–1994 with X‐ray units (250 kV/200 kV, 20 mA, 40 cm SSD), applying a single field of 6 × 8 cm [24]. Seventy‐two heels received 12 Gy with 6 × 1 Gy (three times a week) –6 weeks break – 6 × 1 Gy (group A), 50 heels were treated with 10 × 0.3 Gy every day (group B1), and 38 heels 10 × 0.5 Gy every day (group B2). The endpoint was the value of a semiquantitative pain score 3 months and in mean 4 years after LD‐EBRT.
The median age of patients was 55 years in group A and 59 years in group B1/B2. The mean duration of symptoms before LD‐EBRT was 8 months, in one‐third, the symptoms persisted for more than 6 months.
Complete pain remission was achieved in 68–71% of the patients without significant differences between the treatment groups. However, there were differences in the clinical course of patients with partial remission of the symptoms: The best results in these patients were achieved during longer follow‐up in group B1 (10 × 0.5 Gy), followed by group A (6 × 1–6 × 1 Gy), followed by group B2 (10 × 0.3 Gy). The latter group showed a significantly worse amelioration of symptoms than the other groups.
A reduced efficacy was also reported in another retrospective case series, comprising 673 heels treated with a single dose of 0.3 Gy three times weekly up to 1.5 Gy (X‐ray) [36]. In case of insufficient treatment results the patients were offered a second course. After the first treatment, only 13% reported CR, nearly all patients had undergone a second LD‐EBRT.
Taken together, to the best of our current knowledge a single dose of 0.5 Gy is standard of care and should only be modified in controlled clinical trials.
2.3. Risk factors potentially associated with treatment failure
In Table 3 selected contemporary randomized trials and patient series are shown broken down into several factors that might be correlated with treatment efficacy. For a better overview, we did not differentiate between univariate and multivariate analyses. We did not try to collect all ever published data.
2.3.1. History of symptoms
Duration of symptoms before start of LD‐EBRT has been shown to be correlated with treatment efficacy in numerous studies.
Muecke et al. analyzed in a retrospective multicenter study 502 patients [22]. Duration of symptoms ≤6 months was associated with 76% treatment success vs. 44% after a history >6 months. Also Seegenschmiedt et al. found in their large collectives a correlation between the duration of heel pain and treatment outcome [24]. A significant influence of duration of symptoms before LD‐EBRT was also reported in 73 heels by Schneider et al. [37]. With a history of 3–6 months, the VAS value was reduced by 85%, 28 months after LD‐EBRT in comparison with a reduction of 58% with a history > 6 months. Similar results were obtained by Hermann et al. in 285 heels comparing <12 month history of pain vs. >12 months [38].
In contrary, another study could not confirm these results [30].
2.3.2. Gender
To the best of our knowledge, in no study, an influence of gender on treatment outcome has been confirmed [22, 24, 30, 38, 39]. In contrast to radiotherapy for oncological indications with high doses, efficacy and tolerability of LD‐EBRT seems to be the same concerning gender.
2.3.3. Patients’ age
Several studies described a correlation between older age and better treatment results, at least 6 weeks after LD‐EBRT [37]. Age somewhat over 50 years seems to be important: >50 years [40], > 53 [38], or > 58 [22]. For a possible explanation see Section 2.3.7.
However, other studies found no influence of this patient characteristic on treatment outcome [24, 30, 39].
2.3.4. Initial increase in pain during LD-EBRT
A very precise registration of changes in pain intensity (VAS) was done by Schneider at al. [37]. Sixty‐two patients (73 treated heels) were prospectively scored every week during LD‐EBRT, at the end of therapy, 6 weeks, 28 months, and 40 months later. Additionally, subjective mechanical heel stress during LD‐EBRT was estimated. A linear accelerator (10 MV) was used, applying one single field with a size of 12 × 17 cm. Patients were treated twice a week to a total dose of 5 Gy, with increasing single fraction doses (0.25 – 0.25 – 0.5 – 1 – 1 – 1 – 1 Gy). Mean patient age was 54 years, and all had a radiologically proven plantar spurn, mean symptom duration before LD‐EBRT was 6.5 months. Nearly all patients had received other conservative therapies before LD‐EBRT with insufficient results.
Interestingly, VAS scores decreased continuously during LD‐EBRT: before treatment the mean value was 6.3 ± 1.5, after the first week of LD‐EBRT 6.2 ± 1.8, after the second week 5.5 ± 2 (p < 0.05), after the third 4.7 ± 2.4, and 3.8 ± 2.1 at the end of therapy (p < 0.001). Six weeks later the value further decreased to 3 ± 2.5 (p < 0.004), 28 months after LD‐EBRT to 1.6 ± 2.2 (p < 0.01). One year later no further decrease was noticed (1.8 ± 2.3). Only two patients reported intensification of pain during the LD‐EBRT series. However, these data are not to be extrapolated, as increasing single doses (see above) were used to avoid this phenomenon.
In standard schedules with fixed single doses a slight increase in pain during the treatment series was reported by 26% (during 6 × 0.5 Gy) vs. 29% (6 × 1 Gy) of the patients [30]. Unfortunately, a possible correlation of this phenomenon with definite treatment results was not investigated.
Without further quantification, another study (6 × 1 vs. 6 × 0.1 Gy) stated, that this initial increase in symptoms “had no influence on the final pain relief 3 and 12 months after treatment” [26]. Older studies postulated a temporary reduction of the pH value in the irradiated tissues at the beginning of the treatment series, without consequences for the long‐term efficacy of LD‐EBRT [41].
This is contrasted by observations of LD‐EBRT in peritendinitis humeroscapularis [42]. In 73 patients (86 shoulders) initial increase of pain during the treatment course was significantly associated with a good response.
2.3.5. Use of megavoltage techniques/linear accelerators
Muecke et al. analyzed in a retrospective multicenter study the influence of different treatment techniques in 502 patients [22]. Treatment failure was defined as pain persistence after LD‐EBRT and recurrence of pain during follow‐up. Treatment with MV (6–10 MV) was a significant prognostic factor for pain relief in multivariate analysis, as MV was associated with an eight‐year event‐free probability of 68 vs. 61% after X‐ray beams (175 kV). There are two possible explanations for this finding: besides the possibility of a random result, the authors postulate a more homogenous dose distribution with MV treatment in comparison with KV [22].
2.3.6. Number of therapy courses required
Schneider et al. reported an efficacy of just one‐third after a second LD‐EBRT course (so‐called “re‐irradiation”) in comparison with the effects of the first course [37]. Out of 73 heels treated with 5 Gy LD‐EBRT 18 heels received reirradiation due to insufficient treatment response. However, pain reduction measured by means of changes in VAS shortly after the second course and during long‐term follow‐up was significantly diminished in comparison with the efficacy of the first course (about 30% reduction in pain at the last evaluation vs. 86%).
Similar results were obtained in the large retrospective series (502 patients) by Muecke et al. [22]. Treatment failure was significantly associated with the number of treatment series: eight‐year event‐free probability was about 70% after the first course in comparison with just about 30% after reirradiation.
A systematic study on the efficacy of a reirradiation has been published by Hautmann et al. [43]. Eighty‐three patients (101 heels) with insufficient response to the first course or recurrent pain afterward due to plantar fasciitis (83 heels), or achillodynia (28 heels) received a second LD‐EBRT course in median 10 weeks (range 4 weeks to 63 months) after the first LD‐EBRT. About 75% of the patients were treated with 6 × 1 Gy, the others 6 × 0.5 Gy. The pain was assessed using the numeric rating scale (NRS) before and at the end of LD‐EBRT, 6, and 12 weeks, and 6, 12, and 24 months thereafter.
Before reirradiation NRS values were 6 (interquartile range 5–8), at the end of LD‐EBRT 5 (2–6), 6 weeks later 2 (1–4), at 12 weeks 1 (0–3), at 6 months 0 (0–2), at 12 and 24 months 0 (0–1). Interestingly, not only the patients with recurrent pain after the first course but also patients with insufficient responses to the first course experienced a profound and long‐lasting amelioration of their symptoms after the second course.
This is why a second treatment course should be recommended in case of insufficient efficacy of the first course.
2.3.7. Heel stress during LD-EBRT
A significant correlation between avoidance of heel stress during LD‐EBRT and efficacy of LD‐EBRT 6 weeks after therapy was reported by Schneider et al. in 73 heels [37]. With a Pearson\'s correlation coefficient of -0.467 (p < 0.01) there was an impressing influence of this variable on pain reduction measured by VAS values. However, this correlation was not seen 28 and 40 months after LD‐EBRT.
An intuitive explanation is given by the authors [37]: As patient age was associated with positive treatment results, too, they proposed that older patients are often retired, thus being able to take more care of their heels.
2.3.8. Spur size
Interestingly, all randomized trials required the radiological proof of a heel spur before including patients into the studies. Furthermore, most of the prospective and retrospective series warranted such an objective sign. However, as a substantial part of the patients suffers from plantar heel pain without having developed a heel spur, LD‐EBRT should be effective in these patients, too.
Hermann et al. analyzed treatment efficacy in 250 patients (285 heels), who received LD‐EBRT predominantly with 6 × 1 Gy [38]. In this series, 33% of the treated heels were without radiological evidence of a spur. In 185 patients a spur was confirmed with a mean length of 6.5 mm (range 0.6–25 mm). Patients without evidence of a plantar heel spur had a significantly higher chance of CR after LD‐EBRT (43 vs. 35%). Furthermore, the length of the spurs correlated directly with treatment outcome. Spurs >6.5 mm had just a 30% chance of experiencing CR in comparison with shorter ones. No statistical differences were found between treatment results of heels without spurs and those with spurs ≤6.5 mm.
Miszczyk et al. reported on 327 patients (623 LD‐EBRT series) mostly treated with X‐ray (180 kV, usually 1mm Cu filters) with single doses of 1.5 Gy (range 1–3 Gy) up to a total dose between 9 and 12 Gy (range 1–45 Gy) [39]. Mean spur size was 9 mm (range 1–30 mm). With a mean follow‐up of 74 months, no correlation between spur size and duration of pain relief was found. Analysis concerning spur length and treatment outcome in itself were unfortunately not reported.
2.3.9. The combination of different factors
Multivariate logistic regression enables the identification of factors independently predicting treatment outcome. By combining these factors, models can be calculated, that predict treatment outcome with a high probability. An example from the study of Hermann et al. is given in Table 4: in 285 heels treated with 6 × 1 Gy/6 × 0.5 Gy the influences of the patient characteristics age, spur length, and duration of symptoms before LD-EBRT alone and in combination were calculated [38]. The best results were obtained for patients > 53 years, spur length <6 mm, and a duration of symptoms <12 months with a probability for CR of 55% (CI 36–73%) and PR of 38% (CI 22–58%). Without these characteristics, the chance for CR was just 18% (CI 9–33%), for PR 31% (17–48%).
entire dorsal foot vs. calcaneus vs. insertion of plantar fascia
Dose
6 × 1 vs. 6 × 0.5 Gy
6 × 1 Gy vs. 6 × 0.1 Gy
12, 3, 5 Gy
5 Gy (increasing single dose)
1.5 (1–3) up to 9–12 Gy (1–45)
5–10 × 0.5–1 Gy
6 × 1 Gy6 × 0.5 Gy
6 × 1 Gy
0.3–1.5 Gy; 2–3x weekly 2.5–18.76 Gy
Potential factors
History of symptoms
0
n.i.
+
+
0
+
+
+
+
Gender
0
n.i.
0
n.i.
0
0
0
n.i.
n.i.
Patient\'s age
0
n.i.
0
+
0
+
+
+
n.i.
Initial worsening of pain during LD‐EBRT
n.i.
n.i.
n.i.
n.i.
n.i.
n.i.
n.i.
n.i.
n.i.
MV vs. KV
n.i.
n.i.
n.i.
n.i.
n.i.
+
n.i.
n.i.
0
Number of therapy series
n.i.
n.i.
n.i.
+
n.i.
+
n.i.
n.i.
+
Heel stress during LD‐EBRT
n.i.
0
n.i.
+
n.i.
n.i.
n.i.
n.i.
n.i.
Table 3.
Factors associated with treatment efficacy in contemporary studies.
Note: 0: no correlation with treatment outcome; +: correlation with treatment outcome; n.i.: not investigated; prospect: prospective case series; rand: randomized clinical trial; retrospect: retrospective case series; KV: kilovoltage; MV: megavoltage.
Patient\'s age >53
No spur or spur ≤6.5 mm
Duration of symptoms <12 months
Probability of
No change
Partial remission
Complete remission
1
1
1
0.07 (0.03–0.14)
0.38 (0.22–0.58)
0.55 (0.36–0.73)
1
1
0
0.13 (0.07–0.28)
0.37 (0.21–0.57)
0.50 (0.30–0.70)
1
0
1
0.15 (0.06–0.24)
0.53 (0.33–0.72)
0.32 (0.17–0.53)
1
0
0
0.25 (0.13–0.45)
0.48 (0.27–0.69)
0.27 (0.13–0.48)
0
1
1
0.17 (0.10–0.31)
0.33 (0.19–0.50)
0.50 (0.33–0.66)
0
1
0
0.34 (0.20–0.53)
0.40 (0.24–0.59)
0.26 (0.13–0.45)
0
0
1
0.30 (0.20–0.46)
0.29 (0.18–0.43)
0.41 (0.27–0.56)
0
0
0
0.51 (0.35–0.69)
0.31 (0.17–0.48)
0.18 (0.09–0.33)
Table 4.
Probabilities (95%‐CI) for NC, PR and CR calculated by polytomous logistic regression in dependence of the risk factors age, spur length, and duration of symptoms before LD‐EBRT according to Hermann et al. in a collective of 285 heels treated with 6 × 1/6 × 0.5 Gy (taken from [38]).
2.4. Technique
In modern radiotherapeutic departments, X‐ray sources are less and less available. This is why nowadays most patients are treated with linear accelerators, which were initially developed for the treatment of oncological diseases. However, these machines can be used in the treatment of benign diseases without any modifications or problems. Due to the high efforts in physical, technical, and organizational quality assurances for the operation of an accelerator or an X-ray source, the concentration on accelerators and their use for all indications is recommended.
For irradiation of the heel, the patient has to be placed on the treatment couch with the feet toward the gantry of the accelerator (so‐called “feet first”). Two different patient positions are widely used. He can be placed in supine position, with the irradiated leg is stretched out, while the other leg is angled. Another option is to place the patient in a lateral decubitus position on the side of the involved heel. Again, the symptomatic leg is stretched, while the contralateral leg is bent, with a cushion placed beneath the knee. Using X‐rays, the ipsilateral knee is bent by 90% and the foot is positioned on the treatment table. One anterior‐posterior (AP) beam is usually applied in this technique.
For the treatment itself, there are also two different options. Irradiation may be given as a single stationary field (SSD 100cm by convention). Alternatively, parallel opposing fields from 0° and 180° gantry position (in decubitus position) or lateral opposing fields (90° and 270° in supine position) are also applicable but take a little bit longer in daily clinical practice. The hypothetical advantage of using two opposing fields is a uniform dose distribution in the entire beam path in the calcaneus (Figure 1). However, there has never been a clinical proof, whether this theoretical assumption translates into any clinical advantage for the patient. When applying opposing fields, the dose is specified according to the ICRU 50 report, normally in the center of the calcaneus.
Figure 1.
Dose distribution of two different treatment techniques generated in a treatment planning system (XIO®). In A and B just one single 6 MV photon field (8 × 8 cm) is applied, while C and D shows the dose distribution with two opposing fields from 0 and 180°. In the upper row, the so‐called “beams eye views” are given, while in the lower row the respective dose distributions on an axial CT scan directly at the calcaneal insertion are shown. Note the more uniform dose distribution with opposing fields. The 95% isodose is given as a green line (2.85 Gy). This dose encompasses larger parts of the calcaneal bone in D (opposing fields) than in B (single field). More information is given in Section 2.4.
A third option is the so‐called “plantar field” with the patient lying in prone position. A single field is positioned directly over the plantar insertion/calcaneus, potentially with rotations of the patient table and the gantry to compensate for inclinations of the patients surface in the irradiated field. However, this technique is regarded problematic when using linear accelerators due to the dose build‐up effect in the critical tissue depth. This problem is illustrated in Figure 2: photons with 6 MV reach just the half of the prescribed dose at the skin level, 100% is reached at 1.5 cm tissue depth. This would result in an insufficient dose in the critical structures (plantar fascia and heel spur). To overcome this problem, a silicone flap of about 1 cm diameter must be positioned on the skin before radiation.
Figure 2.
Depth curves of different megavoltage energies. Blue 6 MV photons, red 15 MV photons. At the surface of the body/skin (depth 0 mm), only half (or even less with 15 MV) of the prescribed dose is applied. By physical interactions between photons and the tissue/water, there is a steep increase in dose. A 100% is reached at 1.5 cm depth with 6 MV and at about 3 cm depth with 15 MV. KV‐radiation reaches the maximum dose directly under the surface/skin (not shown). More information is given in Section 2.4.
3. Toxicity and potential risks of LD‐EBRT
Patients are often sent to the radiotherapist after a long unsuccessful history of diverse conservative treatments. The reason for this is a widespread fear among general practitioners that LD‐EBRT might be associated with severe side effects and risks. These fears are not substantiated, as reactions of the nerves or vessels require much higher doses than used for LD‐EBRT. For example, a dose of 45 Gy in normofractionated oncological therapy is considered to be safe for the spinal cord and therefore daily clinical practice [44]. Peripheral nerves are even more radioresistant. Acute or chronic side‐effects have never been reported in all contemporary studies on LD‐EBRT.
3.1. Acute reactions of the skin
Acute side effects are negligible, as very low doses of ionizing radiation (in comparison with oncological treatments) are applied to a distal extremity. The total dose of LD‐EBRT with 3 or 6 Gy is far too low to cause any acute or late reactions on the skin overlaying the calcaneus. During normofractionated EBRT (single doses of 1.8–2 Gy, treatment on 5 days a week) erythema and mild edema develop at about 30 Gy [45]. Hyperpigmentation occurs at about 45 Gy, moist epitheliolyses at about 50 Gy. A 50–60 Gy might cause telangiectasias years after the therapy. This is why there is no report on acute treatment side effects in LD‐EBRT until now to the best of our knowledge.
3.2. Initial increase in pain during LD‐EBRT
About one‐third of the patients might experience a slight increase in pain during LD‐EBRT. In the randomized trial by Heydt et al. this phenomenon was seen in 26% (during 6 × 0.5 Gy) vs. 29% (6 × 1 Gy) [30]. It does not seem to be correlated with treatment outcome; further detailed information is given in Section 2.3.4.
3.3. Impairment of gonad function
The dose scattered to the male gonads is somewhat higher than to the ovaries. Jansen et al. calculated for 6 × 0.5 Gy about 1.5 mSv received by the testes and 0.75 mSv to the ovaries [46]. Comparable results have repeatedly been measured in the past [47, 48].
Taken together, the dose received by the gonads is insignificant. As the distal extremity is irradiated, scattered dose to the gonads is comparable to normal diagnostic radiological imaging [49]. The hereditary effects of these doses are very small and very likely negligible [46].
Although spermatogonial cells are very radiosensitive, a single dose of at least 100 mSv is needed to induce a temporary failure of spermatogenesis [50]. A single dose of 1000 mSv (equivalent to 1 Gy photon irradiation) results in an azoospermia for 9–18 months [51]. Interestingly, fractionated doses harm these cells even more. A temporary oligospermia is reported after receiving several fractions up to a cumulative dose of 160 mSv [52]. An azoospermia lasting for 14–22 months has been reported for fractionated doses of 620–860 mSv [53]. The actually during LD‐EBRT received testicular dose is about 100 times smaller than the lowest dose causing temporary changes in testicular tissues.
The dose to the testicles can be further reduced by utilizing a special testicular shielding. However, clinically meaningful dose reductions have been only measured in MV treatment of subdiaphragmatic/pelvine lymphatic regions or tumors [54, 55].
The mean lethal dose for human oocytes has been estimated at 2 Gy (2000 mSv) [56]. Permanent ovarian failure after radiotherapy is age dependent: in perimenopausal women, a dose of 6 Gy is sufficient [57], while in younger women up to 20 Gy are tolerated. The dose scattered to the ovaries during LD‐EBRT for calcaneodynia cannot cause such sequelae (0.75 mSv).
Naturally, pregnancy has to be excluded in all premenopausal women before beginning with LD‐EBRT, to avoid any risk to the fetus.
3.4. Induction of malignancies
So far, no studies with long‐term observation periods have been published, describing a case of malignancy induced by LD‐EBRT for calcaneodynia. However, induction of malignancies is a stochastic effect of ionizing radiation. This means that there is no threshold dose—in contrast for example to the above‐mentioned reactions of the skin. A photon can accidentally trigger a mutation, which in turn leads to tumor formation many years later. The higher the radiation dose, the higher the probability of such an event occurring.
The best available data on tumor induction of full dose EBRT in oncology has been collected in patients treated with breast cancer. Almost 11,000 patients have been followed for over 20 years. The risk of a radiation‐induced tumor was approx. 1% per decade after radiotherapy [58].
To estimate the risk associated with much lower doses of LD‐EBRT, mathematical models on the basis of epidemiological long‐term observations of atomic bomb victims have been developed by the ICRP [59].
Jansen et al. applied the ICRP model on LD‐EBRT of a painful heel spur [46]. Assumed was a single field entering at the foot sole with a size of 8 × 10 cm, 200 kV photons, SSD 40 cm. For an LD‐EBRT series with 6 × 1 Gy the average attributable lifetime risk for induction of a fatal tumor was calculated to be about 0.5 in a thousand patients. An important risk factor for radiogenic‐induced cancer is the patient\'s age by the time the radiation exposure occurs. The risk is already reduced in the 3rd decade of the patient\'s life, it starts to decrease steadily from the age of 40 [60]. Applying these calculations, the estimated lifetime risk per one thousand patients for a fatal tumor accounts for the age of 25 0.6 (male)/0.8 (female), for the age of 50 0.2/0.3, for the age of 75 0.07/0.1 [46].
However, it must be critically noted that this mathematical model was developed for radiation protection and relates to the exposure of complete organ systems with approx. 1 Gy. Therefore, other groups argue that a significantly lower risk of radiogenic cancer induction— approx. ten times less—should be adopted [49, 61]. Furthermore, taken the new standard scheme with 6 × 0.5 Gy into account, these risks are additionally halved.
This risk (max. 1/1000, very likely much lower) must be seen in relation to the tumor risk of the not additionally radiotherapeutical‐treated population. In 2008, the lifetime risk of a man in Germany to suffer from cancer was 50.7% (25.9% to die from malignancy), in women 42.8% and 20.2% respectively [62].
By limiting the application of LD‐EBRT treatment to patients > 30 years of age, an exposure of the juvenile “relatively higher risk” patient population is avoided.
4. Future perspectives: Definition of questions in further randomized trials and future research
4.1. Target volume definition in LD‐EBRT
Traditionally target volume definition has been quite large. Field sizes of 12 × 17cm were treated, including the entire dorsal and middle foot, and not just the calcaneus [37, 82] (Figure 3A).
Figure 3.
Field definitions in LD‐EBRT of a painful plantar heel spur/fasciitis. (A) traditional field definition including the entire dorsal and middle foot. (B) In randomized trials and large prospective series commonly used field definition encompassing the entire calcaneus, including insertion of the plantar fascia and the Achilles tendon. (C) Proposed small field definition for localized painful plantar fasciitis/plantar spur, encompassing only the painful area with 2 cm margins extending into the neighboring areas (calcaneus, fascia, fat pad).
In the recent randomized trials and prospective observational studies target volume definition was more restricted and confined to the calcaneus (Figure 3B). “The target volume consisted of the calcaneus and the region of the plantar aponeurosis” [26]. “The ventral margin is corresponding to the ventral surface of the calcaneus, the plantar and dorsal margins are surrounding the soft‐tissue border, and the cranial margin is below the ankle” [30]. “Target volume is the calcaneus, normally with a field size of 6 cm × 8 cm” [32]. “The calcaneus and the plantar aponeurosis were included in the target volume” [25].
In a German national survey 2001 on LD‐EBRT of painful heel spurs the target volume definition “large” (dorsal and middle foot) vs. “small” (entire calcaneus) was not correlated with treatment outcome [83]. Consequently, very large field definitions should be regarded as obsolete.
However, as the pathophysiological cause of calcaneodynia is thought to be a localized inflammatory process (see Section 1), it is questionable, whether the entire calcaneus has to be irradiated (as long as there are not a plantar as well as a painful dorsal spurs). There are some clinical data that support a further restriction of target volume definition.
Field sizes have been given in the study by Miszczyk et al. on 327 patients treated with X‐ray beams [39]. Target volume was “… the insertion of the plantar fascia with a calcaneal spur and a reasonable margin. The field size varied from 27 to 150 cm2 (mean 47 cm2).” However, although not explicitly stated, no correlation was found between field size and duration of pain relief after LD‐EBRT. Treatment efficacy in itself was apparently not investigated.
In the above‐mentioned series of 285 heels Hermann et al. analyzed treatment efficacy in dependence of field sizes, too [38]. The mean field size was 74 cm2. No correlation between field size (smaller vs. larger than 74 cm2) with treatment efficacy was found. Further analyses of small fields (< 6 × 6 cm), medium‐sized fields (36–64 cm2) and larger fields revealed no significant differences.
This is why it seems to suffice to encompass the painful region with 2 cm margins extending into the neighboring areas (calcaneus, fascia, fat pad; Figure 3C). However, this recommendation is deducted from pathophysiological considerations and the above‐mentioned case series. A randomized trial is necessary to proof clinical equivalence of a field definition “entire calcaneus” (Figure 3B) vs. “insertion of the plantar fascia” (Figure 3C).
4.2. Fractionation of LD‐EBRT
The optimal fractionation schedule has not been elucidated yet. All randomized trial used twice weekly treatments. Only one experimental arm was scheduled three times a week [25]. In a National Survey in Germany with 146 answering institutions, about 45% applied two fractions and 37.5% three fractions weekly [83].
Interestingly, in the landmark study by von Pannewitz a fractionation schedule of only once per week was established [34]. Until now, there is no proof of a higher efficacy applying LD‐EBRT twice or three times per week.
In radiotherapy of another benign disease (endocrine orbitopathy) a 1 Gy per week over 20 weeks schedule was more effective than the standard schedules (10 × 2 Gy or 10 × 1 Gy every working day) [84]. Although other immunological mechanisms cause endocrine orbitopathy in comparison with plantar fasciitis, there is sufficient clinical evidence to test in a randomized trial different fractionation schedules (twice a week vs. once a week, possibly thrice a week).
4.3. Comparison of LD‐EBRT with other therapies
Other therapies than LD‐EBRT have been applied in painful heel spur. In the following, just a rough overview can be given.
Different kinds of insoles and foot orthoses have been developed. The goal was to reduce plantar contact pressure and to distribute the pressure uniformly over the whole rearfoot [63]. Magnetic insoles do not seem to provide additional benefit [64]. As a short‐term treatment, low‐Dye taping techniques are often used. However, in a randomized trial only a modest improvement in ‘first‐step’ pain was seen in comparison with sham‐intervention [65].
Manual stretching is often recommended. A systematic review of six studies found only statistically significant differences in comparison with the control in one study combining calf muscle and plantar fascia stretches [66].
Several trials have investigated acupuncture. A systematic review from 2010 showed (limited) evidence for the effectiveness [67]. A randomized trial published in 2014 recruited 84 patients [68]. The authors concluded, that “dry needling provided statistically significant reductions in plantar heel pain, but the magnitude of this effect should be considered against the frequency of minor transitory adverse events.”
Ultrasound therapy has led to questionable results [69], but a randomized trial on cryo‐ultrasound with about 100 patients published in 2014 showed good effectiveness [70].
Low‐level laser light (635 nm), given twice a week for a total of six applications, reduced in a randomized trial VAS scores significantly after 8 weeks in comparison with placebo [71]. However, the study comprised of just 69 patients; other similar studies have not been reported so far.
Extracorporeal shock waves are widely applied. Three metaanalyses comprising at least five randomized trials found significant short‐term pain relief and improved functional outcomes for this therapeutic option [72–74]. Another study compared the analgesic efficacy of ultrasound and shock wave therapy in 47 patients [75]. The results suggested that the shock wave therapy had greater analgesic efficacy.
Another basic approach is the oral administration of nonsteroidal anti‐inflammatory drugs (NSAID) to achieve a symptomatic relief. Injections into the painful area are also recommended. A recent review summarized ten randomized trials on corticosteroid injections into the plantar fascia [76]. A significant effect of the steroids on the pain has been shown. However, it was usually short‐term, lasting 4–12 weeks in duration. No advantage of ultrasound‐guided injection techniques in comparison with palpation guidance was found, and no superiority of one type of corticosteroid over another was seen. A longer lasting pain relief has been suggested by a small randomized trial of botulinum toxin injections [77]. Another option is the injection of autologous platelet‐rich plasma. A recent review identified three randomized trials, all showing promising results [78]. However, a very small trial challenged this method of plasma preparation, as the same clinical effectivity was observed after the injection of whole blood [79].
Different surgical approaches have been developed. Releases of the plantar fascia are done, in some studies combined with a spur resection [80]. Due to a probably faster recovery after surgery with comparable functional results endoscopic procedures are recommended nowadays [81]. Surgery is usually indicated after failure of conservative therapies as the ultimate “salvage‐therapy.”
There is only a limited amount of studies randomizing patients between LD‐EBRT and the above‐mentioned alternative therapies.
Canyilmaz et al. randomized 123 patients between LD‐EBRT (6 × 1 Gy, three times a week) and 1 ml injection of 40 mg methylprednisolone and 0.5 ml 60 mg 1% lidocaine under the guidance of palpation [85]. After 3 and 6 months, VAS values and CS‐scores were compared between both groups. After 3 months, the results in the radiotherapy arm were significantly superior compared with those after injections.
To corroborate these findings, similar studies should be conducted. Furthermore, more studies randomizing LD‐EBRT against other therapies (e.g. extracorporeal shock waves) are needed. A minimum size of 50 patients per treatment arm should be assured to gain more statistically relevant results. Recruiting patients without prior excessive other therapies for these studies would be optimal.
The goal must be an evidence‐based algorithm defining the therapeutic sequence of the different conservative treatment modalities for plantar fasciitis.
5. Conclusions
LD‐EBRT for painful plantar fasciitis/heel spur is an effective and safe treatment option for patients over 30 years of age and after exclusion of pregnancy. A fractionation of 6 × 0.5 Gy twice weekly up to a total dose of 3 Gy is currently recommended. In the case of an insufficient response a second course can be offered to the patient.
Randomized trials on target volume definition and further optimization of LD‐EBRT fractionation are currently in the process of planning. Further trials to compare the different conservative therapies for plantar fasciitis with each other are necessary to allow the development of an evidence‐based treatment algorithm.
Acknowledgments
This chapter is dedicated to Professor Gisela Hermann‐Brennecke on the occasion of her 70th birthday.
Abbreviations
AP
anterior‐posterior
CI
confidence interval
CR
complete remission
CS
Calcaneodynia score
Cu
chemical element symbol for copper
EC
endothelial cells
GCG‐BD
German Cooperative Group on Radiotherapy for Benign Diseases
Gy
Gray
ICRP
International Commission on Radiological Protection
IL
interleukin
iNOS
inducible nitric oxide synthases
KV
kilovoltage
LD‐EBRT
low dose external beam radiotherapy
mA
milliampere
mRNA
messenger ribonuclein acid
mSv
milliSievert
MV
megavoltage
NC
no change
NF‐κB
nuclear factor kappa B
NO
nitric oxide
NSAID
non‐steroidal anti‐inflammatory drug
PBMC
peripheral blood mononuclear cells
PR
partial remission
QOL
quality of life
ROS
reactive oxygen species
SSD
skin‐to‐source distance
TGF‐β1
transforming growth factor β1
VAS
visual analogue scale
\n',keywords:"low dose radiotherapy, heel spur, plantar fasciitis, reizbestrahlung, target volume definition",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/53798.pdf",chapterXML:"https://mts.intechopen.com/source/xml/53798.xml",downloadPdfUrl:"/chapter/pdf-download/53798",previewPdfUrl:"/chapter/pdf-preview/53798",totalDownloads:2492,totalViews:768,totalCrossrefCites:0,dateSubmitted:"June 1st 2016",dateReviewed:"November 24th 2016",datePrePublished:null,datePublished:"May 17th 2017",dateFinished:"January 8th 2017",readingETA:"0",abstract:"Degenerative changes in the plantar fascia may cause the so‐called “painful heel” with typical projections of tenderness. This condition is often associated with a plantar heel spur. Radiotherapy with low doses (LD‐EBRT) has been well known for its anti‐inflammatory potential. In the recent years, several microbiological mechanisms were elucidated to explain immunomodulation by LD‐EBRT. Furthermore, a randomized study proved the clinical efficacy of this therapy in plantar fasciitis. Two other trials defined a fractionation schedule of 6 × 0.5 Gy twice weekly as the new standard therapy. Taken together, LD‐EBRT is an effective and safe therapeutic option for patients over 30 years of age and after exclusion of pregnancy. In case of an insufficient response, a second course can be offered to the patient. There are still open questions concerning target volume definition and fractionation of LD‐EBRT. Furthermore, studies randomizing LD‐EBRT with other conservative therapeutic approaches are missing.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/53798",risUrl:"/chapter/ris/53798",signatures:"Robert Michael Hermann, Frank Bruns and Mirko Nitsche",book:{id:"5611",type:"book",title:"Radiotherapy",subtitle:null,fullTitle:"Radiotherapy",slug:"radiotherapy",publishedDate:"May 17th 2017",bookSignature:"Cem Onal",coverURL:"https://cdn.intechopen.com/books/images_new/5611.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-953-51-3150-2",printIsbn:"978-953-51-3149-6",pdfIsbn:"978-953-51-4833-3",isAvailableForWebshopOrdering:!0,editors:[{id:"43940",title:"Dr.",name:"Cem",middleName:null,surname:"Onal",slug:"cem-onal",fullName:"Cem Onal"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"192941",title:"Prof.",name:"Robert",middleName:"Michael",surname:"Hermann",fullName:"Robert Hermann",slug:"robert-hermann",email:"hermann@strahlentherapie-westerstede.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Hannover Medical School",institutionURL:null,country:{name:"Germany"}}},{id:"194730",title:"Dr.",name:"Mirko",middleName:null,surname:"Nitsche",fullName:"Mirko Nitsche",slug:"mirko-nitsche",email:"Nitsche@strahlentherapie-bremen.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"194927",title:"Dr.",name:"Frank",middleName:null,surname:"Bruns",fullName:"Frank Bruns",slug:"frank-bruns",email:"bruns.frank@mh-hannover.de",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Incidence and etiology of plantar fasciitis",level:"1"},{id:"sec_2",title:"2. Treatment with LD‐EBRT",level:"1"},{id:"sec_2_2",title:"2.1. Biological effects of LD‐EBRT on lymphocytes and inflammatory processes",level:"2"},{id:"sec_3_2",title:"2.2. Results of randomized trials on radiotherapy for painful heel spur",level:"2"},{id:"sec_3_3",title:"Table 1.",level:"3"},{id:"sec_4_3",title:"2.2.2. Looking for the minimum effective dose: optimization of fractionation and total dose of LD-EBRT",level:"3"},{id:"sec_4_4",title:"2.2.2.1. Single dose 0.5 vs. 1 Gy",level:"4"},{id:"sec_5_4",title:"2.2.2.2. Single dose 0.3 vs. 1 Gy",level:"4"},{id:"sec_8_2",title:"2.3. Risk factors potentially associated with treatment failure",level:"2"},{id:"sec_8_3",title:"2.3.1. History of symptoms",level:"3"},{id:"sec_9_3",title:"2.3.2. Gender",level:"3"},{id:"sec_10_3",title:"2.3.3. Patients’ age",level:"3"},{id:"sec_11_3",title:"2.3.4. Initial increase in pain during LD-EBRT",level:"3"},{id:"sec_12_3",title:"2.3.5. Use of megavoltage techniques/linear accelerators",level:"3"},{id:"sec_13_3",title:"2.3.6. Number of therapy courses required",level:"3"},{id:"sec_14_3",title:"2.3.7. Heel stress during LD-EBRT",level:"3"},{id:"sec_15_3",title:"2.3.8. Spur size",level:"3"},{id:"sec_16_3",title:"Table 3.",level:"3"},{id:"sec_18_2",title:"2.4. Technique",level:"2"},{id:"sec_20",title:"3. Toxicity and potential risks of LD‐EBRT",level:"1"},{id:"sec_20_2",title:"3.1. Acute reactions of the skin",level:"2"},{id:"sec_21_2",title:"3.2. Initial increase in pain during LD‐EBRT",level:"2"},{id:"sec_22_2",title:"3.3. Impairment of gonad function",level:"2"},{id:"sec_23_2",title:"3.4. Induction of malignancies",level:"2"},{id:"sec_25",title:"4. Future perspectives: Definition of questions in further randomized trials and future research",level:"1"},{id:"sec_25_2",title:"4.1. Target volume definition in LD‐EBRT",level:"2"},{id:"sec_26_2",title:"4.2. Fractionation of LD‐EBRT",level:"2"},{id:"sec_27_2",title:"4.3. Comparison of LD‐EBRT with other therapies",level:"2"},{id:"sec_29",title:"5. Conclusions",level:"1"},{id:"sec_30",title:"Acknowledgments",level:"1"},{id:"sec_32",title:"Abbreviations",level:"1"}],chapterReferences:[{id:"B1",body:'Yi TI, Lee GE, Seo IS, Huh WS, Yoon TH, Kim BR. Clinical characteristics of the causes of plantar heel pain. Ann Rehabil Med. 2011;35:507–513. DOI: 10.5535/arm.2011.35.4.507'},{id:"B2",body:'Irving DB, Cook JL, Young MA, Menz HB. Obesity and pronated foot type may increase the risk of chronic plantar heel pain: a matched case‐control study. BMC Musculoskelet Disord. 2007;8:41. DOI: 10.1186/1471‐2474‐8‐41'},{id:"B3",body:'Sahin N, Oztürk A, Atıcı T. Foot mobility and plantar fascia elasticity in patients with plantar fasciitis. Acta Orthop Traumatol Turc. 2010;44:385–91. 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DOI: 10.1016/0958‐3947(95)02003‐9'},{id:"B55",body:'Bieri S, Rouzaud M, Miralbell R. Seminoma of the testis: is scrotal shielding necessary when radiotherapy is limited to the para‐aortic nodes? Radiother Oncol. 1999;50:349–353. DOI: 10.1016/S0167‐8140(99)00023‐7'},{id:"B56",body:'Wallace WH, Thomson AB, Kelsey TW. The radiosensitivity of the human oocyte. Hum Reprod. 2003;18:117–121. DOI: 10.1093/humrep/deg016'},{id:"B57",body:'Bianchi M. Cytotoxic insult to germinal tissue, part 2; the ovary. In: Potten CS, Hendry JH, editors. Cytotoxic Insult to Tissue: Effects on Cell Lineages. Edinburgh, UK: Churchill‐Livingstone; 1983. pp. 309–328.'},{id:"B58",body:'Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Effect of radiotherapy after breast‐conserving surgery on 10‐year recurrence and 15‐year breast cancer death: meta‐analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet 2011;378:1707–1716. DOI: 10.1016/S0140‐6736(11)61629‐2'},{id:"B59",body:'International Commission on Radiological Protection (ICRP) 1990 Recommendations of the International Commission on Radiological Protection. ICRP Publication 60. Annals of the ICRP 21, 1–3, Oxford (UK): Pergamon Press; 1991.'},{id:"B60",body:'Broerse JJ, Snijders‐Keilholz A, Jansen JT et al. Assessment of a carcinogenic risk for treatment of Graves’ ophthalmopathy in dependence on age and irradiation geometry. Radiother Oncol. 1999;53:205–208. DOI: 10.1016/S0167‐8140(99)00118‐8'},{id:"B61",body:'McKeown SR, Hatfield P, Prestwich RJ, Shaffer RE, Taylor RE. Radiotherapy for benign disease; assessing the risk of radiation‐induced cancer following exposure to intermediate dose radiation. Br J Radiol. 2015;88:20150405. DOI: 10.1259/bjr.20150405'},{id:"B62",body:'Robert Koch‐Institut und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e.V. [Cancer in Germany] 2007/2008. 8th ed. Berlin; 2012. DOI: 10.17886/rkipubl‐2015‐004'},{id:"B63",body:'Chia KK, Suresh S, Kuah A, Ong JL, Phua JM, Seah AL. Comparative trial of the foot pressure patterns between corrective orthotics, formthotics, bone spur pads and flat insoles in patients with chronic plantar fasciitis. Ann Acad Med Singapore. 2009;38:869–875. PMID: 19890578'},{id:"B64",body:'Winemiller MH, Billow RG, Laskowski ER, Harmsen WS. Effect of magnetic vs sham‐magnetic insoles on plantar heel pain: a randomized controlled trial. JAMA. 2003;290:1474–1478. DOI: 10.1001/jama.290.11.1474'},{id:"B65",body:'Radford JA, Landorf KB, Buchbinder R, Cook C. Effectiveness of low‐Dye taping for the short‐term treatment of plantar heel pain: a randomised trial. BMC Musculoskelet Disord. 2006;7:64. DOI: 10.1186/1471‐2474‐7‐64'},{id:"B66",body:'Sweeting D, Parish B, Hooper L, Chester R. The effectiveness of manual stretching in the treatment of plantar heel pain: a systematic review. J Foot Ankle Res. 2011;4:19. DOI: 10.1186/1757‐1146‐4‐19'},{id:"B67",body:'Cotchett MP, Landorf KB, Munteanu SE. Effectiveness of dry needling and injections of myofascial trigger points associated with plantar heel pain: a systematic review. J Foot Ankle Res. 2010;3:18. DOI: 10.1186/1757‐1146‐3‐18'},{id:"B68",body:'Cotchett MP, Munteanu SE, Landorf KB. Effectiveness of trigger point dry needling for plantar heel pain: a randomized controlled trial. Phys Ther. 2014;94:1083–1094. DOI: 10.2522/ptj.20130255'},{id:"B69",body:'Crawford F, Snaith M. How effective is therapeutic ultrasound in the treatment of heel pain? Ann Rheum Dis. 1996;55:265–267. DOI: 10.1136/ard.55.4.265'},{id:"B70",body:'Costantino C, Vulpiani MC, Romiti D, Vetrano M, Saraceni VM. Cryoultrasound therapy in the treatment of chronic plantar fasciitis with heel spurs. A randomized controlled clinical study. Eur J Phys Rehabil Med. 2014;50:39–47. PMID: 24172641'},{id:"B71",body:'Macias DM, Coughlin MJ, Zang K, Stevens FR, Jastifer JR, Doty JF. Low‐Level laser therapy at 635 nm for treatment of chronic plantar fasciitis: a placebo‐controlled, randomized study. J Foot Ankle Surg. 2015;54:768–72. DOI: 10.1053/j.jfas.2014.12.014'},{id:"B72",body:'Yin MC, Ye J, Yao M, Cui XJ, Xia Y, Shen QX, Tong ZY, Wu XQ, Ma JM, Mo W. Is extracorporeal shock wave therapy clinical efficacy for relief of chronic, recalcitrant plantar fasciitis? A systematic review and meta‐analysis of randomized placebo or active‐treatment controlled trials. Arch Phys Med Rehabil. 2014;95:1585–1593. DOI: 10.1016/j.apmr.2014.01.033'},{id:"B73",body:'Aqil A, Siddiqui MR, Solan M, Redfern DJ, Gulati V, Cobb JP. Extracorporeal shock wave therapy is effective in treating chronic plantar fasciitis: a meta‐analysis of RCTs. Clin Orthop Relat Res. 2013;471:3645–3652. DOI: 10.1007/s11999‐013‐3132‐2'},{id:"B74",body:'Zhiyun L, Tao J, Zengwu S. Meta‐analysis of high‐energy extracorporeal shock wave therapy in recalcitrant plantar fasciitis. Swiss Med Wkly. 2013;143:w13825. DOI: 10.4414/smw.2013.13825'},{id:"B75",body:'Krukowska J, Wrona J, Sienkiewicz M, Czernicki J. A comparative analysis of analgesic efficacy of ultrasound and shock wave therapy in the treatment of patients with inflammation of the attachment of the plantar fascia in the course of calcaneal spurs. Arch Orthop Trauma Surg. 2016. [Epub ahead of print] DOI: 10.1007/s00402‐016‐2503‐z'},{id:"B76",body:'Ang TW. The effectiveness of corticosteroid injection in the treatment of plantar fasciitis. Singapore Med J. 2015;56:423–432. DOI: 10.11622/smedj.2015118'},{id:"B77",body:'Díaz‐Llopis IV, Gómez‐Gallego D, Mondéjar‐Gómez FJ, López‐García A, Climent‐Barberá JM, Rodríguez‐Ruiz CM. Botulinum toxin type A in chronic plantar fasciitis: clinical effects one year after injection. Clin Rehabil. 2013;27:681–685. DOI: 10.1177/0269215512469217'},{id:"B78",body:'Franceschi F, Papalia R, Franceschetti E, Paciotti M, Maffulli N, Denaro V. Platelet‐rich plasma injections for chronic plantar fasciopathy: a systematic review. Br Med Bull. 2014;112:83–95. DOI: 10.1093/bmb/ldu025'},{id:"B79",body:'Vahdatpour B, Kianimehr L, Ahrar MH. Autologous platelet‐rich plasma compared with whole blood for the treatment of chronic plantar fasciitis; a comparative clinical trial. Adv Biomed Res. 2016;5:84. DOI: 10.4103/2277‐9175.182215'},{id:"B80",body:'Tomczak RL, Haverstock BD. A retrospective comparison of endoscopic plantar fasciotomy to open plantar fasciotomy with heel spur resection for chronic plantar fasciitis/heel spur syndrome. J Foot Ankle Surg. 1995;34:305–311. DOI: 10.1016/S1067‐2516(09)80065‐3'},{id:"B81",body:'Chou AC, Ng SY, Koo KO. Endoscopic plantar fasciotomy improves early postoperative results: a retrospective comparison of outcomes after endoscopic versus open plantar fasciotomy. J Foot Ankle Surg. 2016;55:9–15. DOI: 10.1053/j.jfas.2015.02.005'},{id:"B82",body:'Mantell BS. Radiotherapy for painful heel syndrome. Br Med J. 1978;2:90–91. PMID: 667574'},{id:"B83",body:'Micke O, Seegenschmiedt MH. Radiotherapy in painful heel spurs (plantar fasciitis): results of a national patterns of care study. Int J Radiat Oncol Biol Phys 2004;58:828–843. DOI: 10.1016/S0360‐3016(03)01620‐1'},{id:"B84",body:'Kahaly GJ, Rösler HP, Pitz S, Hommel G. Low‐ versus high‐dose radiotherapy for Graves’ ophthalmopathy: a randomized, single blind trial. J Clin Endocrinol Metab. 2000;85:102–108. DOI: 10.1210/jcem.85.1.6257'},{id:"B85",body:'Canyilmaz E, Canyilmaz F, Aynaci O, Colak F, Serdar L, Uslu GH, Aynaci O, Yoney A. Prospective randomized comparison of the effectiveness of radiation therapy and local steroid injection for the treatment of plantar fasciitis. Int J Radiat Oncol Biol Phys. 2015;92:659–666. DOI: 10.1016/j.ijrobp.2015.02.009'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Robert Michael Hermann",address:"hermann@strahlentherapie-westerstede.com",affiliation:'
Center for Radiotherapy and Radiooncology, Bremen and Westerstede, Westerstede, Germany
Department of Radiotherapy and Special Oncology, Hannover Medical School, Hannover, Germany
Center for Radiotherapy and Radiooncology, Bremen and Westerstede, Westerstede, Germany
Department of Radiotherapy, Karl‐Lennert Cancer Center, University of Schleswig‐Holstein, Kiel, Germany
'}],corrections:null},book:{id:"5611",type:"book",title:"Radiotherapy",subtitle:null,fullTitle:"Radiotherapy",slug:"radiotherapy",publishedDate:"May 17th 2017",bookSignature:"Cem Onal",coverURL:"https://cdn.intechopen.com/books/images_new/5611.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-953-51-3150-2",printIsbn:"978-953-51-3149-6",pdfIsbn:"978-953-51-4833-3",isAvailableForWebshopOrdering:!0,editors:[{id:"43940",title:"Dr.",name:"Cem",middleName:null,surname:"Onal",slug:"cem-onal",fullName:"Cem Onal"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"108266",title:"Prof.",name:"Tomio",middleName:null,surname:"Kurokawa",email:"kurokawa@aitech.ac.jp",fullName:"Tomio Kurokawa",slug:"tomio-kurokawa",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"1",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:{name:"Aichi Institute of Technology",institutionURL:null,country:{name:"Japan"}}},booksEdited:[],chaptersAuthored:[{id:"33405",title:"Genetic Algorithm Application for Trading in Market toward Stable Profitable Method",slug:"genetic-algorithm-application-for-trading-in-market-toward-stable-profitable-method",abstract:null,signatures:"Tomio Kurokawa",authors:[{id:"108266",title:"Prof.",name:"Tomio",surname:"Kurokawa",fullName:"Tomio Kurokawa",slug:"tomio-kurokawa",email:"kurokawa@aitech.ac.jp"}],book:{id:"2285",title:"Genetic Algorithms in Applications",slug:"genetic-algorithms-in-applications",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"99771",title:"Dr.",name:"Osama",surname:"Mahmood Al-Rawi",slug:"osama-mahmood-al-rawi",fullName:"Osama Mahmood Al-Rawi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99771/images/1190_n.png",biography:"Dr. Osama Y. Mahmood Al-Rawi was born in Baghdad, Iraq, in 1967. He received the B. Sc. Degree in Electrical & Electronics Engineering from the University of Technology, Baghdad, Iraq in 1989. The M.Sc. and Ph.D. degrees in Control System Engineering from the University of Technology, Baghdad, Iraq, in 1995 and 2003, respectively.\n\nHe was shared and carried out many practical projects in different locations and companies in Iraq. These companies are belonging to the ministries of industry, communications and others. In addition he worked in some companies as a consultant engineer on some projects that has been submitted and implemented at that time in different interested fields. He was worked as a FACULTY MEMBER and LECTURER in Engineering colleges of the following universities; University of Technology, University of Baghdad, both in Baghdad/ Iraq, Ittihad Private University Al-Rakka/Syria. He is currently a lecturer at Department of Electrical and Electronics/College of Engineering /Gulf University, kingdom of Bahrain. Some of his published papers.\n[1] \\Improving GPS Accuracy By Using Genetic Algorithms\\, IEEE, Third International Conference on Systems, Signals & Devices, Communication and signal processing, Vol. III, CSP-34-, March 21-24, 2005, Sousse, Tunisia.\n[2] “Switching Angle Optimization Based Genetic Algorithms for Harmonic Reduction in Three-Phase PWM Inverters”, The International Workshop on Symbolic and Numerical Methods, Modeling and Applications to Circuit Design, SM2ACD 2010, The 11th edition will be organized in Tunisia on October 5-6, 2010.\n[3] “Microcontroller Servomotor for Maximum Effective Power Point for Solar Cell System”, the 10th International Conference for Enhanced Building Operations (ICEBO) in Kuwait on 26-28 October 2010.\nHis professional experience includes teaching and research at the university as well as working in industry. His theoretical and practical interest includes modeling and control of uncertain and nonlinear systems, Artificial intelligence, power electronics applications, Power generation and conversions.",institutionString:null,institution:{name:"Gulf University",institutionURL:null,country:{name:"Bahrain"}}},{id:"107249",title:"Dr.",name:"Goran",surname:"Stojanovski",slug:"goran-stojanovski",fullName:"Goran Stojanovski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/107249/images/282_n.jpg",biography:"Goran Stojanovski is born on 1st of March 1984 in Resen, Macedonia. \nHe has received his B.Eng. and M.Sc. degrees in Electrical Engineering from SS Cyril and Methodius University at the Faculty of Electrical Eng. & Information Technologies in Skopje, Macedonia in 2007 and 2009, respectively. Currently, he is a PhD candidate working on advanced algorithms for switched model predictive control. He has a couple of journal and more than 15 conference papers published. 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Cyril and Methodius",institutionURL:null,country:{name:"Slovakia"}}},{id:"110138",title:"Dr.",name:"Qibo",surname:"Peng",slug:"qibo-peng",fullName:"Qibo Peng",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National University of Defense Technology",institutionURL:null,country:{name:"China"}}},{id:"110816",title:"Prof.",name:"Limin",surname:"Jia",slug:"limin-jia",fullName:"Limin Jia",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Beijing Jiaotong University",institutionURL:null,country:{name:"China"}}},{id:"112426",title:"Prof.",name:"Chien-Min",surname:"Ou",slug:"chien-min-ou",fullName:"Chien-Min Ou",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Chien Hsin University of Science and Technology",institutionURL:null,country:{name:"Taiwan"}}},{id:"113313",title:"Dr.",name:"Abdel-Aal",surname:"Mantawy",slug:"abdel-aal-mantawy",fullName:"Abdel-Aal Mantawy",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ain Shams University",institutionURL:null,country:{name:"Egypt"}}},{id:"115763",title:"Prof.",name:"Mile",surname:"Stankovski",slug:"mile-stankovski",fullName:"Mile Stankovski",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ss. Cyril and Methodius",institutionURL:null,country:{name:"Slovakia"}}},{id:"116046",title:"MSc.",name:"Ghasem",surname:"Karimi",slug:"ghasem-karimi",fullName:"Ghasem Karimi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",institutionURL:null,country:{name:"Iran"}}},{id:"116055",title:"MSc.",name:"Omid",surname:"Jahanian",slug:"omid-jahanian",fullName:"Omid Jahanian",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",institutionURL:null,country:{name:"Iran"}}},{id:"116622",title:"Prof.",name:"Seiji",surname:"Aoyagi",slug:"seiji-aoyagi",fullName:"Seiji Aoyagi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Kansai University",institutionURL:null,country:{name:"Japan"}}}]},generic:{page:{slug:"OA-publishing-fees",title:"Open Access Publishing Fees",intro:"
The Open Access model is applied to all of our publications and is designed to eliminate subscriptions and pay-per-view fees. This approach ensures free, immediate access to full text versions of your research.
As a gold Open Access publisher, an Open Access Publishing Fee is payable on acceptance following peer review of the manuscript. In return, we provide high quality publishing services and exclusive benefits for all contributors. IntechOpen is the trusted publishing partner of over 140,000 international scientists and researchers.
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The Open Access Publishing Fee (OAPF) is payable only after your book chapter, monograph or journal article is accepted for publication.
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1,400 GBP Chapter - Edited Volume
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850 GBP Chapter - Book Series Topic (Annual Volume)
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10,000 GBP Monograph - Long Form
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4,000 GBP Compacts Monograph - Short Form
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850 GBP Journal Article (Across Portfolio)
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During the launching phase journals do not charge an APC, rather they will be funded by IntechOpen.
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*These prices do not include Value-Added Tax (VAT). Residents of European Union countries need to add VAT based on the specific rate in their country of residence. Institutions and companies registered as VAT taxable entities in their own EU member state will not pay VAT as long as provision of the VAT registration number is made during the application process. This is made possible by the EU reverse charge method.
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Services included are:
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An online manuscript tracking system to facilitate your work
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English language copyediting and proofreading, including the correction of grammatical, spelling, and other common errors
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XML Typesetting and pagination - web (PDF, HTML) and print files preparation
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Discoverability - electronic citation and linking via DOI
\\n\\t
Permanent and unrestricted online access to your work
\\n
\\n\\n
What isn't covered by the Open Access Publishing Fee?
\\n\\n
If your manuscript:
\\n\\n
\\n\\t
Exceeds the number of pages defined by the publishing guidelines, an additional fee per page may be required
\\n\\t
If a manuscript requires Heavy Editing or Language Polishing, this will incur additional fees.
\\n
\\n\\n
Your Author Service Manager will inform you of any items not covered by the OAPF and provide exact information regarding those additional costs before proceeding.
\\n\\n
Open Access Funding
\\n\\n
To explore funding opportunities and learn more about how you can finance your IntechOpen publication, go to our Open Access Funding page. IntechOpen offers expert assistance to all of its Authors. We can support you in approaching funding bodies and institutions in relation to publishing fees by providing information about compliance with the Open Access policies of your funder or institution. We can also assist with communicating the benefits of Open Access in order to support and strengthen your funding request and provide personal guidance through your application process. You can contact us at funders@intechopen.com for further details or assistance.
\\n\\n
For Authors who are still unable to obtain funding from their institutions or research funding bodies for individual projects, IntechOpen does offer the possibility of applying for a Waiver to offset some or all processing feed. Details regarding our Waiver Policy can be found here.
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Added Value of Publishing with IntechOpen
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Choosing to publish with IntechOpen ensures the following benefits:
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\\n\\t
Indexing and listing across major repositories, see details ...
\\n\\t
Long-term archiving
\\n\\t
Visibility on the world's strongest OA platform
\\n\\t
Live Performance Metrics to track readership and the impact of your chapter
\\n\\t
Dissemination and Promotion
\\n
\\n\\n
Benefits of Publishing with IntechOpen
\\n\\n
\\n\\t
Proven world leader in Open Access book publishing with over 10 years experience
\\n\\t
+5,700 OA books published
\\n\\t
Most competitive prices in the market
\\n\\t
Fully compliant with OA funding requirements
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Optimized processes that assure your research is made available to the scientific community without delay
\\n\\t
Personal support during every step of the publication process
\\n\\t
+184,650 citations in Web of Science databases
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Currently strongest OA platform with over 175 million downloads
As a gold Open Access publisher, an Open Access Publishing Fee is payable on acceptance following peer review of the manuscript. In return, we provide high quality publishing services and exclusive benefits for all contributors. IntechOpen is the trusted publishing partner of over 140,000 international scientists and researchers.
\n\n
The Open Access Publishing Fee (OAPF) is payable only after your book chapter, monograph or journal article is accepted for publication.
\n\n
OAPF Publishing Options
\n\n
\n\t
1,400 GBP Chapter - Edited Volume
\n\t
850 GBP Chapter - Book Series Topic (Annual Volume)
\n\t
10,000 GBP Monograph - Long Form
\n\t
4,000 GBP Compacts Monograph - Short Form
\n\t
850 GBP Journal Article (Across Portfolio)
\n
\n\n
During the launching phase journals do not charge an APC, rather they will be funded by IntechOpen.
\n\n
*These prices do not include Value-Added Tax (VAT). Residents of European Union countries need to add VAT based on the specific rate in their country of residence. Institutions and companies registered as VAT taxable entities in their own EU member state will not pay VAT as long as provision of the VAT registration number is made during the application process. This is made possible by the EU reverse charge method.
\n\n
Services included are:
\n\n
\n\t
An online manuscript tracking system to facilitate your work
\n\t
Personal contact and support throughout the publishing process from your dedicated Author Service Manager
\n\t
Assurance that your manuscript meets the highest publishing standards
\n\t
English language copyediting and proofreading, including the correction of grammatical, spelling, and other common errors
\n\t
XML Typesetting and pagination - web (PDF, HTML) and print files preparation
\n\t
Discoverability - electronic citation and linking via DOI
\n\t
Permanent and unrestricted online access to your work
\n
\n\n
What isn't covered by the Open Access Publishing Fee?
\n\n
If your manuscript:
\n\n
\n\t
Exceeds the number of pages defined by the publishing guidelines, an additional fee per page may be required
\n\t
If a manuscript requires Heavy Editing or Language Polishing, this will incur additional fees.
\n
\n\n
Your Author Service Manager will inform you of any items not covered by the OAPF and provide exact information regarding those additional costs before proceeding.
\n\n
Open Access Funding
\n\n
To explore funding opportunities and learn more about how you can finance your IntechOpen publication, go to our Open Access Funding page. IntechOpen offers expert assistance to all of its Authors. We can support you in approaching funding bodies and institutions in relation to publishing fees by providing information about compliance with the Open Access policies of your funder or institution. We can also assist with communicating the benefits of Open Access in order to support and strengthen your funding request and provide personal guidance through your application process. You can contact us at funders@intechopen.com for further details or assistance.
\n\n
For Authors who are still unable to obtain funding from their institutions or research funding bodies for individual projects, IntechOpen does offer the possibility of applying for a Waiver to offset some or all processing feed. Details regarding our Waiver Policy can be found here.
\n\n
Added Value of Publishing with IntechOpen
\n\n
Choosing to publish with IntechOpen ensures the following benefits:
\n\n
\n\t
Indexing and listing across major repositories, see details ...
\n\t
Long-term archiving
\n\t
Visibility on the world's strongest OA platform
\n\t
Live Performance Metrics to track readership and the impact of your chapter
\n\t
Dissemination and Promotion
\n
\n\n
Benefits of Publishing with IntechOpen
\n\n
\n\t
Proven world leader in Open Access book publishing with over 10 years experience
\n\t
+5,700 OA books published
\n\t
Most competitive prices in the market
\n\t
Fully compliant with OA funding requirements
\n\t
Optimized processes that assure your research is made available to the scientific community without delay
\n\t
Personal support during every step of the publication process
\n\t
+184,650 citations in Web of Science databases
\n\t
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Theories on the basis of which this research was focused on identification of the level of development of the management culture in order to implement corporate social responsibility are identified, and the stages of its implementation are described.",book:{id:"5791",slug:"management-culture-and-corporate-social-responsibility",title:"Management Culture and Corporate Social Responsibility",fullTitle:"Management Culture and Corporate Social Responsibility"},signatures:"Pranas Žukauskas, Jolita Vveinhardt and Regina Andriukaitienė",authors:[{id:"179629",title:"Prof.",name:"Jolita",middleName:null,surname:"Vveinhardt",slug:"jolita-vveinhardt",fullName:"Jolita Vveinhardt"}]},{id:"74550",title:"School Conflicts: Causes and Management Strategies in Classroom Relationships",slug:"school-conflicts-causes-and-management-strategies-in-classroom-relationships",totalDownloads:2098,totalCrossrefCites:1,totalDimensionsCites:10,abstract:"Conflicts cannot cease to exist, as they are intrinsic to human beings, forming an integral part of their moral and emotional growth. Likewise, they exist in all schools. The school is inserted in a space where the conflict manifests itself daily and assumes relevance, being the result of the multiple interpersonal relationships that occur in the school context. Thus, conflict is part of school life, which implies that teachers must have the skills to manage conflict constructively. Recognizing the diversity of school conflicts, this chapter aimed to present its causes, highlighting the main ones in the classroom, in the teacher-student relationship. It is important to conflict face and resolve it with skills to manage it properly and constructively, establishing cooperative relationships, and producing integrative solutions. Harmony and appreciation should coexist in a classroom environment and conflict should not interfere, negatively, in the teaching and learning process. This bibliography review underscore the need for during the teachers’ initial training the conflict management skills development.",book:{id:"7827",slug:null,title:"Interpersonal Relationships",fullTitle:"Interpersonal Relationships"},signatures:"Sabina Valente, Abílio Afonso Lourenço and Zsolt Németh",authors:null},{id:"58969",title:"Corruption, Causes and Consequences",slug:"corruption-causes-and-consequences",totalDownloads:27405,totalCrossrefCites:11,totalDimensionsCites:13,abstract:"Corruption is a constant in the society and occurs in all civilizations; however, it has only been in the past 20 years that this phenomenon has begun being seriously explored. It has many different shapes as well as many various effects, both on the economy and the society at large. Among the most common causes of corruption are the political and economic environment, professional ethics and morality and, of course, habits, customs, tradition and demography. Its effects on the economy (and also on the wider society) are well researched, yet still not completely. Corruption thus inhibits economic growth and affects business operations, employment and investments. It also reduces tax revenue and the effectiveness of various financial assistance programs. The wider society is influenced by a high degree of corruption in terms of lowering of trust in the law and the rule of law, education and consequently the quality of life (access to infrastructure, health care). There also does not exist an unambiguous answer as to how to deal with corruption. Something that works in one country or in one region will not necessarily be successful in another. This chapter tries to answer at least a few questions about corruption and the causes for it, its consequences and how to deal with it successfully.",book:{id:"6487",slug:"trade-and-global-market",title:"Trade and Global Market",fullTitle:"Trade and Global Market"},signatures:"Štefan Šumah",authors:[{id:"228073",title:"Mr.",name:"Stefan",middleName:null,surname:"Sumah",slug:"stefan-sumah",fullName:"Stefan Sumah"}]},{id:"55499",title:"Human Resources Management in Nonprofit Organizations: A Case Study of Istanbul Foundation for Culture and Arts",slug:"human-resources-management-in-nonprofit-organizations-a-case-study-of-istanbul-foundation-for-cultur",totalDownloads:2198,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The aim of this study is to investigate the efficiency and importance of human resources management in nonprofit organizations. The understanding was included to the literature as personnel management at the beginning of the twentieth century and it turned into an approach as human resources management in the 1980s. It could be observed that many organizations, which deem the human as the most critical stakeholder, adopt a traditional way of personnel management in operating human resources. The employees play a key role in the success of an organization. For this reason, subjects such as recruitment, training, development, career management, performance appraisal, occupational health, and safety are the fundamental functions of human resources management. The study examines to what extent these roles are evaluated through a case study. The subject matter of the study is the most powerful culture and art foundation in Turkey. Compared to many other nonprofit organizations, the foundation actively performs a variety of services within a year worldwide. The fact that the total number of employees might rise up to 800, including the field personnel, indicates the need of a good functioning human resources management. The human resources practices of the foundation are examined and evaluated within that scope.",book:{id:"5826",slug:"issues-of-human-resource-management",title:"Issues of Human Resource Management",fullTitle:"Issues of Human Resource Management"},signatures:"Beste Gökçe Parsehyan",authors:[{id:"189113",title:"Dr.",name:"Beste",middleName:null,surname:"Gokce Parsehyan",slug:"beste-gokce-parsehyan",fullName:"Beste Gokce Parsehyan"}]},{id:"59152",title:"Marketing Strategies for the Social Good",slug:"marketing-strategies-for-the-social-good",totalDownloads:1534,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Social network sites (SNS) have proven to be a good environment to promote and sell goods and services, but marketing is more than creating commercial strategies. Social marketing strategies can also be used to promote behavioral change and help individuals transform their lives, achieve well-being, and adopt prosocial behaviors. In this chapter, we seek to analyze with a netnographic study, how SNS are being employed by nonprofits and nongovernment organizations (NGOs) to enable citizens and consumers to participate in different programs and activities that promote social transformation and well-being. A particular interest is to identify how organizations are using behavioral economic tactics to nudge individuals and motivate them to engage in prosocial actions. By providing an understanding on how SNS can provide an adequate environment for the design of social marketing strategies, we believe our work has practical implications both for academicians and marketers who want to contribute in the transformation of consumer behavior and the achievement of well-being and social change.",book:{id:"6583",slug:"marketing",title:"Marketing",fullTitle:"Marketing"},signatures:"Alicia De La Pena",authors:[{id:"196878",title:"Dr.",name:"Alicia",middleName:null,surname:"De La Pena",slug:"alicia-de-la-pena",fullName:"Alicia De La Pena"}]}],onlineFirstChaptersFilter:{topicId:"4",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81882",title:"The Importance of Supporting Creativity Development as the Main Skill of the Twenty-First Century",slug:"the-importance-of-supporting-creativity-development-as-the-main-skill-of-the-twenty-first-century",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.104919",abstract:"This chapter calls into question the ways of creativity development as the main skill of the twenty-first century. Attention is paid to the analysis of key notions and concepts of creativity. This chapter discusses how to enhance creative thinking skills during training in higher institutions. The study presents the results gained from the literature overview. The examples of assignments aimed at creative thinking skills development during training are given. The paper investigates approaches to the construction of tasks to develop creative thinking and criteria for creativity assessment. An analysis has allowed highlighting the positive experience of different experts researched creativity, which can be implemented in future training in Ukrainian higher educational institutions. The findings of this study support the idea that heuristic tasks, creative projects, mind maps, and case study are significant assignments in the enhancement of creativity development that can be supported in the educational process and everyday life.",book:{id:"11303",title:"Creativity",coverURL:"https://cdn.intechopen.com/books/images_new/11303.jpg"},signatures:"Iryna Simkova, Kateryna Tuliakova, Oksana Serheieva and Oksana Pastushenko"},{id:"81735",title:"Research Status in Computational Thinking in STEM Education",slug:"research-status-in-computational-thinking-in-stem-education",totalDownloads:4,totalDimensionsCites:0,doi:"10.5772/intechopen.104472",abstract:"Computational thinking (CT) is an approach to problem-solving that has its roots in computer science. However, its inherent value in the science, technology, engineering, and mathematics (STEM) disciplines cannot be over-emphasized, considering that we are in the fourth industrial revolution. The chapter draws attention to its close affinity to problem-solving and programming, and the impact of computational thinking on the labour market, and in turn the digital economy is highlighted. A global overview of recent research findings and initiatives to implement CT education in school curricula are discussed. Because of the importance of STEM education, and the inherent value of CT, it is necessary to explore the status and inclinations of CT in STEM disciplines. Hence, a snapshot of research over the last two years was used in a systematic review to determine the trends and challenges for integrating CT in the curriculum of STEM related fields. Using the ERIC database of journals, and specific criteria for selection of publications, 31 articles were examined in this study. Overall, it was found several tools and instructional strategies are used to develop CT, but more needs to be done to increase teachers’ knowledge and enactment for CT in the STEM fields.",book:{id:"11279",title:"Advances in Research in STEM Education",coverURL:"https://cdn.intechopen.com/books/images_new/11279.jpg"},signatures:"Irene Govender"},{id:"81642",title:"Sustainability of Soil Chemical Properties and Nutrient Relationships in Dairy and Beef Cattle in Antioquia, Colombia",slug:"sustainability-of-soil-chemical-properties-and-nutrient-relationships-in-dairy-and-beef-cattle-in-an",totalDownloads:6,totalDimensionsCites:0,doi:"10.5772/intechopen.104647",abstract:"This chapter has been written with the purpose of increasing knowledge regarding the characteristics of soils dedicated to dairy and beef cattle farming in Antioquia, Colombia. Statistical analysis included several generalised additive models, with additive, smoothing, and tensor effects, such as geographic position and chemical parameters. Findings showed most farms belonged to small producers, 86.5% of cattle farms being family owned. Rotational grazing is the predominant system in 93% of farms; 58% of dairy farms and 94% of beef cattle farms do not fertilise their pastures. Results show high variability of soil chemical parameters. There are high levels of iron and low levels of sodium. Macronutrients, such as phosphorus and potassium show high levels in some dairy subregions and medium to low levels in others. Calcium (Ca) and magnesium levels are low for all subregions, excluding “Urabá” and “Occidente.” Most subregions have organic matter (OM) levels below 13%. The distribution of some chemical parameters is related to geographical location, such as pH and Ca, which change according to latitude and longitude. Different correlations were found amongst OM, total nitrogen, Ca, and exchangeable aluminium. Due to the high variability of soil fertility parameters, management programmes should be implemented for each distinctive production system.",book:{id:"11253",title:"Sustainable Rural Development",coverURL:"https://cdn.intechopen.com/books/images_new/11253.jpg"},signatures:"Marisol Medina-Sierra, Mario Cerón-Muñoz and Luis Galeano-Vasco"},{id:"81831",title:"Deep Network Model and Regression Analysis using OLS Method for Predicting Lung Vital Capacity",slug:"deep-network-model-and-regression-analysis-using-ols-method-for-predicting-lung-vital-capacity",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.104737",abstract:"With the advancement of technology, many new devices and methods with machine learning and artificial intelligence (ML-AI) have been developed and these methods have begun to play an important role in human life. ML-AI technology is now widely used in many applications such as security, military, communications, bioengineering, medical treatment, food industry, and robotics. In this chapter, deep learning methods and medical usage techniques that have become popular in recent years will be discussed. Experimental and simulation results and a comprehensive example of the biomedical use of the deep network model will be presented. In addition, the regression analysis using the ordinary least squares (OLS) method for estimating lung vital capacity (VC) will be discussed. 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Departing from either localism or cosmopolitanism in thinking earth, globe, and the environment, this chapter aims at a theoretical critique of the very notion of “environment” as the guiding notion of what the expression “environmental crisis” spells. Perhaps, “environmental crisis” is less a description of “our” situation, and more an indication of a problem formulated not strongly enough? The notion of “environment” and “environmental crisis” predetermines the currently regnant approaches to global warming, air and soil pollution, nature preservation, and reducing the human impact on the environment. At the same time, the notion of “environment” steers its adherents toward the modern natural science as both (1) the ultimate contributor to the environmental crisis due to technology and (2) the ultimate instrument to save us from the apocalyptic swirl, in which technology drives humanity. Linking environmental crisis to science, which is only an instrument of both its creation and management, forecloses a more fundamental human dimension of that crisis. 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In particular, the concern for human coping mechanisms and survival in today’s fast paced environment dictates a growing need to address conflicts of inner and outer lived experiences, dissociation, and trauma, where traditional settings are failing or inadequate. Ethical considerations and applications for working outside in nature are discussed, as well as limitations for traditional settings. 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The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"25",title:"Environmental Sciences",doi:"10.5772/intechopen.100362",issn:"2754-6713",scope:"
\r\n\tScientists have long researched to understand the environment and man’s place in it. The search for this knowledge grows in importance as rapid increases in population and economic development intensify humans’ stresses on ecosystems. Fortunately, rapid increases in multiple scientific areas are advancing our understanding of environmental sciences. Breakthroughs in computing, molecular biology, ecology, and sustainability science are enhancing our ability to utilize environmental sciences to address real-world problems. \r\n\tThe four topics of this book series - Pollution; Environmental Resilience and Management; Ecosystems and Biodiversity; and Water Science - will address important areas of advancement in the environmental sciences. They will represent an excellent initial grouping of published works on these critical topics.
",coverUrl:"https://cdn.intechopen.com/series/covers/25.jpg",latestPublicationDate:"April 13th, 2022",hasOnlineFirst:!1,numberOfPublishedBooks:1,editor:{id:"197485",title:"Dr.",name:"J. Kevin",middleName:null,surname:"Summers",slug:"j.-kevin-summers",fullName:"J. Kevin Summers",profilePictureURL:"https://mts.intechopen.com/storage/users/197485/images/system/197485.jpg",biography:"J. Kevin Summers is a Senior Research Ecologist at the Environmental Protection Agency’s (EPA) Gulf Ecosystem Measurement and Modeling Division. He is currently working with colleagues in the Sustainable and Healthy Communities Program to develop an index of community resilience to natural hazards, an index of human well-being that can be linked to changes in the ecosystem, social and economic services, and a community sustainability tool for communities with populations under 40,000. He leads research efforts for indicator and indices development. Dr. Summers is a systems ecologist and began his career at the EPA in 1989 and has worked in various programs and capacities. This includes leading the National Coastal Assessment in collaboration with the Office of Water which culminated in the award-winning National Coastal Condition Report series (four volumes between 2001 and 2012), and which integrates water quality, sediment quality, habitat, and biological data to assess the ecosystem condition of the United States estuaries. He was acting National Program Director for Ecology for the EPA between 2004 and 2006. He has authored approximately 150 peer-reviewed journal articles, book chapters, and reports and has received many awards for technical accomplishments from the EPA and from outside of the agency. 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He also has an honorary appointment to serve as a Collaborative Professor at Kanazawa University, Japan, from Mar 2015 to the present. \nFormerly, Dr. Rahman was a faculty member of the University of Chittagong, Bangladesh, affiliated with the Department of Chemistry (Oct 2002 to Mar 2012) and the Department of Applied Chemistry and Chemical Engineering (Mar 2012 to Sep 2015). Dr. Rahman was also adjunctly attached with Kanazawa University, Japan (Visiting Research Professor, Dec 2014 to Mar 2015; JSPS Postdoctoral Research Fellow, Apr 2012 to Mar 2014), and Tokyo Institute of Technology, Japan (TokyoTech-UNESCO Research Fellow, Oct 2004–Sep 2005). \nHe received his Ph.D. degree in Environmental Analytical Chemistry from Kanazawa University, Japan (2011). He also achieved a Diploma in Environment from the Tokyo Institute of Technology, Japan (2005). Besides, he has an M.Sc. degree in Applied Chemistry and a B.Sc. degree in Chemistry, all from the University of Chittagong, Bangladesh. \nDr. Rahman’s research interest includes the study of the fate and behavior of environmental pollutants in the biosphere; design of low energy and low burden environmental improvement (remediation) technology; implementation of sustainable waste management practices for treatment, handling, reuse, and ultimate residual disposition of solid wastes; nature and type of interactions in organic liquid mixtures for process engineering design applications.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorTwo:{id:"201020",title:"Dr.",name:"Zinnat Ara",middleName:null,surname:"Begum",slug:"zinnat-ara-begum",fullName:"Zinnat Ara Begum",profilePictureURL:"https://mts.intechopen.com/storage/users/201020/images/system/201020.jpeg",biography:"Zinnat A. 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The research focus of Dr. Zinnat includes the effect of the relative stability of metal-chelator complexes in the environmental remediation process designs and the development of eco-friendly soil washing techniques using biodegradable chelators.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorThree:null},{id:"39",title:"Environmental Resilience and Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/39.jpg",isOpenForSubmission:!0,editor:{id:"137040",title:"Prof.",name:"Jose",middleName:null,surname:"Navarro-Pedreño",slug:"jose-navarro-pedreno",fullName:"Jose Navarro-Pedreño",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRAXrQAO/Profile_Picture_2022-03-09T15:50:19.jpg",biography:"Full professor at University Miguel Hernández of Elche, Spain, previously working at the University of Alicante, Autonomous University of Madrid and Polytechnic University of Valencia. Graduate in Sciences (Chemist), graduate in Geography and History (Geography), master in Water Management, Treatment, master in Fertilizers and Environment and master in Environmental Management; Ph.D. in Environmental Sciences. His research is focused on soil-water and waste-environment relations, mainly on soil-water and soil-waste interactions under different management and waste reuse. His work is reflected in more than 230 communications presented in national and international conferences and congresses, 29 invited lectures from universities, associations and government agencies. 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He has developed his research activity in the fields of fauna and soil ecology, and in the treatment of organic waste, having been the founder and principal investigator of the Environmental Biotechnology Group of the University of Vigo.\r\nHis research activity in the field of Environmental Biotechnology has been focused on the development of novel organic waste treatment systems through composting. 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He was also invited to serve as an associate editor for special issues of the Journal of the American Water Resources Association. He has served as an editorial member for international journals such as Hydrology, Journal of Ecology & Natural Resources, and Hydro Science & Marine Engineering, among others. He has chaired or acted as a technical committee member for twenty-five international forums (conferences). Dr. Shang graduated from Tsinghua University, China, in 2010 with a Ph.D. in Engineering. Prior to that, he worked as a research fellow at Harvard University from 2008 to 2009. 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He received his Ph.D. in Environmental Analytical Chemistry from Assiut University, Egypt, in 1989. His research interest is in analytical and environmental chemistry with special emphasis on: (1) monitoring and assessing biological trace elements and toxic metals in human blood, urine, water, crops, vegetables, and medicinal plants; (2) relationships between environmental heavy metals and human diseases; (3) uses of biological indicators for monitoring water pollution; (4) environmental chemistry of lakes, rivers, and well water; (5) water and wastewater treatment by adsorption and photocatalysis techniques; (6) soil and water pollution monitoring, control, and treatment; and (7) advanced oxidation treatment. Prof. Rashed has supervised several MSc and Ph.D. theses in the field of analytical and environmental chemistry. He served as an examiner for several Ph.D. theses in analytical chemistry in India, Kazakhstan, and Botswana. He has published about ninety scientific papers in peer-reviewed international journals and several papers in national and international conferences. He participated as an invited speaker at thirty international conferences. Prof. Rashed is the editor-in-chief and an editorial board member for several international journals in the fields of chemistry and environment. He is a member of several national and international societies. He received the Egyptian State Award for Environmental Research in 2001 and the Aswan University Merit Award for Basic Science in 2020. 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He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. 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He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). 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He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/us