Trials documenting improvement in cardiovascular outcomes and reduced cardiovascular mortality with renin-angiotensin-aldosterone system inhibition.
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5496",leadTitle:null,fullTitle:"Fault Diagnosis and Detection",title:"Fault Diagnosis and Detection",subtitle:null,reviewType:"peer-reviewed",abstract:"Mass production companies have become obliged to reduce their production costs and sell more products with lower profit margins in order to survive in competitive market conditions. The complexity and automation level of machinery are continuously growing. This development calls for some of the most critical issues that are reliability and dependability of automatic systems. In the future, machines will be monitored remotely, and computer-aided techniques will be employed to detect faults in the future, and also there will be unmanned factories where machines and systems communicate to each other, detect their own faults, and can remotely intercept their faults. The pioneer studies of such systems are fault diagnosis studies. Thus, we hope that this book will contribute to the literature in this regard.",isbn:"978-953-51-3204-2",printIsbn:"978-953-51-3203-5",pdfIsbn:"978-953-51-4822-7",doi:"10.5772/63169",price:139,priceEur:155,priceUsd:179,slug:"fault-diagnosis-and-detection",numberOfPages:336,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"9d27af6f557a4c54b28af7072dc3fcb6",bookSignature:"Mustafa Demetgul and Muhammet Ünal",publishedDate:"May 31st 2017",coverURL:"https://cdn.intechopen.com/books/images_new/5496.jpg",numberOfDownloads:21721,numberOfWosCitations:34,numberOfCrossrefCitations:34,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:56,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:124,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 28th 2016",dateEndSecondStepPublish:"May 19th 2016",dateEndThirdStepPublish:"August 23rd 2016",dateEndFourthStepPublish:"November 21st 2016",dateEndFifthStepPublish:"December 21st 2016",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"19106",title:"Dr.",name:"Mustafa",middleName:null,surname:"Demetgul",slug:"mustafa-demetgul",fullName:"Mustafa Demetgul",profilePictureURL:"https://mts.intechopen.com/storage/users/19106/images/5677_n.jpg",biography:"Mustafa Demetgul was born in Duzce, Turkey, in 1978. He received the BSc degree, MS degree, and PhD degree in Mechanical Engineering from Marmara University, Istanbul, Turkey. From 2007 to 2009, he was a postdoc with the Mechanical Engineering Department, Florida International University, Florida, USA. Here he has been involved in research on structural health monitoring and energy harvesting. He currently works at the Department of Mechatronics Engineering, Marmara University, as an Assoc. Prof. Dr. His research interests are fault diagnosis, energy harvesting, intelligent materials, automation systems, structural health monitoring, and artificial intelligence systems. He is the director of Fault Diagnosis and Structural Health Monitoring Lab in Marmara University. He is an editorial board member at many international journals. He has publications in many international journals and symposiums on failure diagnosis and fault detection.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"193819",title:"Dr.",name:"Muhammet",middleName:null,surname:"Ünal",slug:"muhammet-unal",fullName:"Muhammet Ünal",profilePictureURL:"https://mts.intechopen.com/storage/users/193819/images/5678_n.jpg",biography:"Dr. Muhammet Ünal works as an assistant professor in the Department of Mechatronics Engineering, Marmara University, Istanbul (Turkey). His research interests are system identification, parameter optimization, real-time control, and structural health monitoring. His primary research interests are vibration analysis and fault diagnosis of mechanical systems. Dr. Ünal has written several papers in vrious fields of mechatronics engineering and one book on control engineering.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"717",title:"Control Theory",slug:"engineering-control-engineering-control-theory"}],chapters:[{id:"54861",title:"Fault Detection and Isolation",doi:"10.5772/67870",slug:"fault-detection-and-isolation",totalDownloads:1868,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Fault diagnosis of a class of linear multiple‐input and multiple‐output (MIMO) systems is developed here. An emulator‐based scheme is proposed to detect and isolate faults in a system formed by interconnected subsystems. Emulators, which are hardware or software devices, are connected to the input and measurement outputs in cascade with the subsystems whose faults are to be diagnosed. The role of an emulator is to induce variations in cascade combination of the nominal fault‐free subsystem so as to mimic the actual perturbations that may occur in the subsystem during the offline identification phase. The emulator‐generated data are employed in the reliable identification of the nominal system, the associated Kalman filter, and a map that relates the emulator parameters to the feature vector. In the operational stage, the Kalman filter residual is used to detect a fault in the system; the emulator parameter that has varied is estimated, and using the emulator‐feature vector map, the faulty subsystem is isolated. The main contributions of this work are accurate and reliable identification of the system, the fault diagnosis of multivariable systems using feature vector-emulator map fault diagnosis of multivariable systems, and the establishment of the key properties of the Kalman filter for fault detection. The proposed scheme was successfully evaluated on a number of simulated as well as physical systems.",signatures:"Rajamani Doraiswami and Lahouari Cheded",downloadPdfUrl:"/chapter/pdf-download/54861",previewPdfUrl:"/chapter/pdf-preview/54861",authors:[{id:"28398",title:"Prof.",name:"Rajamani",surname:"Doraiswami",slug:"rajamani-doraiswami",fullName:"Rajamani Doraiswami"},{id:"37808",title:"Prof.",name:"Lahouari",surname:"Cheded",slug:"lahouari-cheded",fullName:"Lahouari Cheded"}],corrections:null},{id:"54590",title:"Adaptive Signal Decomposition Methods for Vibration Signals of Rotating Machinery",doi:"10.5772/67530",slug:"adaptive-signal-decomposition-methods-for-vibration-signals-of-rotating-machinery",totalDownloads:1848,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Vibration‐based condition monitoring and fault diagnosis are becoming more common in the industry to increase machine availability and reliability. Considerable research efforts have recently been directed towards the development of adaptive signal processing methods for fault diagnosis. Two adaptive signal decomposition methods, i.e. the empirical mode decomposition (EMD) and the local mean decomposition (LMD), are widely used. This chapter is intended to summarize the recent developments mostly based on the authors’ works. It aims to provide a valuable reference for readers on the processing and analysis of vibration signals collected from rotating machinery.",signatures:"Wei Guo and Ming J. Zuo",downloadPdfUrl:"/chapter/pdf-download/54590",previewPdfUrl:"/chapter/pdf-preview/54590",authors:[{id:"191997",title:"Dr.",name:"Wei",surname:"Guo",slug:"wei-guo",fullName:"Wei Guo"},{id:"192000",title:"Prof.",name:"Ming J.",surname:"Zuo",slug:"ming-j.-zuo",fullName:"Ming J. Zuo"},{id:"192189",title:"Dr.",name:"Wenhua",surname:"Chen",slug:"wenhua-chen",fullName:"Wenhua Chen"}],corrections:null},{id:"53779",title:"Enhanced Principles in Design of Adaptive Fault Observers",doi:"10.5772/67133",slug:"enhanced-principles-in-design-of-adaptive-fault-observers",totalDownloads:1312,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In this chapter, modified techniques for fault estimation in linear dynamic systems are proposed, which give the possibility to simultaneously estimate the system state as well as slowly varying faults. Using the continuous-time adaptive observer form, the considered faults are assumed to be additive, thereby the principles can be applied for a broader class of fault signals. Enhanced algorithms using H∞ approach are provided to verify stability of the observers, giving algorithms with improved performance of fault estimation. Exploiting the procedure for transforming the model with additive faults into an extended form, the proposed technique allows to obtain fault estimates that can be used for fault compensation in the fault tolerant control scheme. Analyzing the ambit of performances given on the mixed H2/H∞ design of the fault tolerant control, the joint design conditions are formulated as a minimization problem subject to convex constraints expressed by a system of linear matrix inequalities. Applied enhanced design conditions increase estimation rapidity also in noise environment and formulate a general framework for fault estimation using augmented or adaptive observer structures and active fault tolerant control in linear dynamic systems.",signatures:"Dušan Krokavec, Anna Filasová and Pavol Liščinský",downloadPdfUrl:"/chapter/pdf-download/53779",previewPdfUrl:"/chapter/pdf-preview/53779",authors:[{id:"18818",title:"Prof.",name:"Dušan",surname:"Krokavec",slug:"dusan-krokavec",fullName:"Dušan Krokavec"},{id:"22287",title:"Prof.",name:"Anna",surname:"Filasová",slug:"anna-filasova",fullName:"Anna Filasová"},{id:"195026",title:"Dr.",name:"Pavol",surname:"Liscinsky",slug:"pavol-liscinsky",fullName:"Pavol Liscinsky"}],corrections:null},{id:"54865",title:"An Assessment on the Non-Invasive Methods for Condition Monitoring of Induction Motors",doi:"10.5772/67917",slug:"an-assessment-on-the-non-invasive-methods-for-condition-monitoring-of-induction-motors",totalDownloads:2130,totalCrossrefCites:8,totalDimensionsCites:11,hasAltmetrics:0,abstract:"The ability to forecast motor mechanical faults at incipient stages is vital to reducing maintenance costs, operation downtime and safety hazards. This paper synthesized the progress in the research and development in condition monitoring and fault diagnosis of induction motors. The motor condition monitoring techniques are mainly classified into two categories that are invasive and non-invasive techniques. The invasive techniques are very basic, but they have some implementation difficulties and high cost. The non-invasive methods, namely MCSA, PVA and IPA, overcome the disadvantages associated to invasive methods. This book chapter reviews the various non-invasive condition monitoring methods for diagnosis of mechanical faults in induction motor and concludes that the instantaneous power analysis (IPA) and Park vector analysis (PVA) methods are best suitable for the diagnosis of small fault signatures associated to mechanical faults. Recommendations for the future research in these areas are also presented.",signatures:"Muhammad Irfan, Nordin Saad, Rosdiazli Ibrahim, Vijanth S.\nAsirvadam, Abdullah S. Alwadie and Muhammad Aman Sheikh",downloadPdfUrl:"/chapter/pdf-download/54865",previewPdfUrl:"/chapter/pdf-preview/54865",authors:[{id:"9739",title:"Dr.",name:"Nordin",surname:"Saad",slug:"nordin-saad",fullName:"Nordin Saad"},{id:"174671",title:"Dr.",name:"Rosdiazli B. Ibrahim",surname:"Ibrahim",slug:"rosdiazli-b.-ibrahim-ibrahim",fullName:"Rosdiazli B. Ibrahim Ibrahim"},{id:"177286",title:"Dr.",name:"Muhammad",surname:"Irfan",slug:"muhammad-irfan",fullName:"Muhammad Irfan"},{id:"191337",title:"Dr.",name:"Vijanth",surname:"Sagayan",slug:"vijanth-sagayan",fullName:"Vijanth Sagayan"},{id:"192401",title:"Dr.",name:"Muhammad Aman",surname:"Sheikh",slug:"muhammad-aman-sheikh",fullName:"Muhammad Aman Sheikh"},{id:"205830",title:"Prof.",name:"Abdullah",surname:"Alwadie",slug:"abdullah-alwadie",fullName:"Abdullah Alwadie"}],corrections:null},{id:"54322",title:"Evaluation of Novelty Detection Methods for Condition Monitoring applied to an Electromechanical System",doi:"10.5772/67531",slug:"evaluation-of-novelty-detection-methods-for-condition-monitoring-applied-to-an-electromechanical-sys",totalDownloads:1564,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Dealing with industrial applications, the implementation of condition monitoring schemes must overcome a critical limitation, that is, the lack of a priori information about fault patterns of the system under analysis. Indeed, classical diagnosis schemes, in general, outdo the membership probability of a measure in regard to predefined operating scenarios. However, dealing with noncharacterized systems, the knowledge about faulty operating scenarios is limited and, consequently, the diagnosis performance is insufficient. In this context, the novelty detection framework plays an essential role for monitoring systems in which the information about different operating scenarios is initially unavailable or restricted. The novelty detection approach begins with the assumption that only data corresponding to the healthy operation of the system under analysis is available. Thus, the challenge is to detect and learn additional scenarios during the operation of the system in order to complement the information obtained by the diagnosis scheme. This work has two main objectives: first, the presentation of novelty detection as the current trend toward the new paradigm of industrial condition monitoring and, second, the introduction to its applicability by means of analyses of different novelty detection strategies over a real industrial system based on rotatory machinery.",signatures:"Miguel Delgado Prieto, Jesús A. Cariño Corrales, Daniel Zurita\nMillán, Marta Millán Gonzalvez, Juan A. Ortega Redondo and René\nde J. Romero Troncoso",downloadPdfUrl:"/chapter/pdf-download/54322",previewPdfUrl:"/chapter/pdf-preview/54322",authors:[{id:"190434",title:"Dr.",name:"Miguel",surname:"Delgado-Prieto",slug:"miguel-delgado-prieto",fullName:"Miguel Delgado-Prieto"},{id:"194487",title:"MSc.",name:"Jesus A.",surname:"Cariño",slug:"jesus-a.-carino",fullName:"Jesus A. Cariño"},{id:"194935",title:"MSc.",name:"Daniel",surname:"Zurita-Millán",slug:"daniel-zurita-millan",fullName:"Daniel Zurita-Millán"},{id:"194936",title:"MSc.",name:"Marta",surname:"Millán Gonzalvez",slug:"marta-millan-gonzalvez",fullName:"Marta Millán Gonzalvez"},{id:"194937",title:"Dr.",name:"Juan A.",surname:"Ortega Redondo",slug:"juan-a.-ortega-redondo",fullName:"Juan A. Ortega Redondo"},{id:"194938",title:"Dr.",name:"René De J.",surname:"Romero Troncoso",slug:"rene-de-j.-romero-troncoso",fullName:"René De J. Romero Troncoso"}],corrections:null},{id:"54040",title:"Fault Diagnosis and Health Assessment for Rotating Machinery Based on Kernel Density Estimation and Kullback-Leibler Divergence",doi:"10.5772/67360",slug:"fault-diagnosis-and-health-assessment-for-rotating-machinery-based-on-kernel-density-estimation-and-",totalDownloads:1343,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"To avoid severe damages and unexpected shutdowns, fault diagnosis and health assessment of rotating machinery have received considerable attention in recent years. On the other hand, as a great amount of data become acquirable and accessible in industry, data-driven tools have become an emerging research area, acting as a complement to the model-based (or physics-based) fault diagnosis and health assessment methods. In this chapter, based on the kernel density estimation (KDE) and the Kullback-Leibler divergence (KLID), a new data-driven fault diagnosis approach and a new health assessment approach are introduced. By utilizing the KDE, the statistical distribution of selected features can be readily estimated without assuming any parametric family of distributions, whereas the KLID is able to quantify the discrepancy between two probability distributions of selected features. An integrated Kullback-Leibler divergence, which aggregates the KLID of all the selected features, is introduced to discriminate various fault types or health status of rotating machinery. The effectiveness of the proposed approaches is demonstrated through three case studies of fault diagnosis and health assessment of rotating machinery.",signatures:"Yu Liu, Chen-Yao Yan and Fan Zhang",downloadPdfUrl:"/chapter/pdf-download/54040",previewPdfUrl:"/chapter/pdf-preview/54040",authors:[{id:"190539",title:"Dr.",name:"Yu",surname:"Liu",slug:"yu-liu",fullName:"Yu Liu"}],corrections:null},{id:"54206",title:"Dynamics-Based Vibration Signal Modeling for Tooth Fault Diagnosis of Planetary Gearboxes",doi:"10.5772/67529",slug:"dynamics-based-vibration-signal-modeling-for-tooth-fault-diagnosis-of-planetary-gearboxes",totalDownloads:2271,totalCrossrefCites:5,totalDimensionsCites:6,hasAltmetrics:0,abstract:"Vibration analysis has been widely used to diagnose gear tooth fault inside a planetary gearbox. However, the vibration characteristics of a planetary gearbox are very complicated. Inside a planetary gearbox, there are multiple vibration sources as several sun-planet gear pairs, and several ring-planet gear pairs are meshing simultaneously. In addition, due to the rotation of the carrier, distance varies between vibration sources and a transducer installed on the planetary gearbox housing. Dynamics-based vibration signal modeling techniques can simulate the vibration signals of a planetary gearbox and reveal the signal generation mechanism and fault features effectively. However, these techniques are basically in the theoretical development stage. Comprehensive experimental validations are required for their future applications in real systems. This chapter describes the methodologies related to vibration signal modeling of a planetary gear set for gear tooth damage diagnosis. The main contents include gear mesh stiffness evaluation, gear tooth crack modeling, dynamic modeling of a planetary gear set, vibration source modeling, modeling of transmission path effect due to the rotation of the carrier, sensor perceived vibration signal modeling, and vibration signal decomposition techniques. The methods presented in this chapter can help understand the vibration properties of planetary gearboxes and give insights into developing new signal processing methods for gear tooth damage diagnosis.",signatures:"Xihui Liang, Ming J. Zuo and Wenhua Chen",downloadPdfUrl:"/chapter/pdf-download/54206",previewPdfUrl:"/chapter/pdf-preview/54206",authors:[{id:"191577",title:"Dr.",name:"Xihui",surname:"Liang",slug:"xihui-liang",fullName:"Xihui Liang"}],corrections:null},{id:"54144",title:"Fault-Tolerant Electrical Machines and Drives",doi:"10.5772/67354",slug:"fault-tolerant-electrical-machines-and-drives",totalDownloads:1549,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The last years of research and development in the automotive industry were still focused on designing electrical propulsion units to be eco-friendly and diminish the drawbacks of classical combustion engines. Besides being energy efficient, silent, and high in power density, these must have a serious fault-tolerant ability as driver, and passengers’ safety is probably the most important issue in this filed. The chapter will detail fault-tolerant machines and power electronic architectures with their control for the most common ones, such as switched reluctance machines (SRM) and the permanent-magnet synchronous machines (PMSM). Besides detection, solutions will be presented for the machine-drive unit to wisely overcome and compensate occurred faults. A novel modular structure of SRM is presented with increased fault tolerance and possibility of fast repair in case of any machine damage. The solutions will be validated via simulated and experiment-based results.",signatures:"Mircea Ruba",downloadPdfUrl:"/chapter/pdf-download/54144",previewPdfUrl:"/chapter/pdf-preview/54144",authors:[{id:"190371",title:"Dr.",name:"Mircea",surname:"Ruba",slug:"mircea-ruba",fullName:"Mircea Ruba"}],corrections:null},{id:"54834",title:"Fault Detection and Isolation of Nonlinear Systems with Generalized Hamiltonian Representation",doi:"10.5772/68084",slug:"fault-detection-and-isolation-of-nonlinear-systems-with-generalized-hamiltonian-representation",totalDownloads:1342,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The problem of fault diagnosis in a class of nonlinear system is considered. Systems that can be written in the so‐called Generalized Hamiltonian Representation (which is equivalent to an Euler‐Lagrange representation) are studied, and a model‐based observer approach for this class of systems is developed. The main advantage of the proposed approach is the facility to design the required observers, which take advantage of the system structure given by the Hamitonian representation. In order to show the proposed schema, a model of a permanent magnet synchronous machine is revised and the fault diagnosis schema presented. Simulation results confirm the effectivity of the proposed schema.",signatures:"Luis Humberto Rodriguez-Alfaro, Efrain Alcorta-Garcia, Cornelio\nPosadas-Castillo and David Alejandro Diaz-Romero",downloadPdfUrl:"/chapter/pdf-download/54834",previewPdfUrl:"/chapter/pdf-preview/54834",authors:[{id:"191626",title:"Prof.",name:"Efrain",surname:"Alcorta-Garcia",slug:"efrain-alcorta-garcia",fullName:"Efrain Alcorta-Garcia"},{id:"191943",title:"Dr.",name:"Luis Humberto",surname:"Rodriguez Alfaro",slug:"luis-humberto-rodriguez-alfaro",fullName:"Luis Humberto Rodriguez Alfaro"},{id:"191944",title:"Prof.",name:"Cornelio",surname:"Posadas Castillo",slug:"cornelio-posadas-castillo",fullName:"Cornelio Posadas Castillo"},{id:"191946",title:"Prof.",name:"David Alejandro",surname:"Diaz Romero",slug:"david-alejandro-diaz-romero",fullName:"David Alejandro Diaz Romero"}],corrections:null},{id:"54400",title:"Process Monitoring Using Data-Based Fault Detection Techniques: Comparative Studies",doi:"10.5772/67347",slug:"process-monitoring-using-data-based-fault-detection-techniques-comparative-studies",totalDownloads:2079,totalCrossrefCites:15,totalDimensionsCites:27,hasAltmetrics:0,abstract:"Data based monitoring methods are often utilized to carry out fault detection (FD) when process models may not necessarily be available. The partial least square (PLS) and principle component analysis (PCA) are two basic types of multivariate FD methods, however, both of them can only be used to monitor linear processes. Among these extended data based methods, the kernel PCA (KPCA) and kernel PLS (KPLS) are the most well-known and widely adopted. KPCA and KPLS models have several advantages, since, they do not require nonlinear optimization, and only the solution of an eigenvalue problem is required. Also, they provide a better understanding of what kind of nonlinear features are extracted: the number of the principal components (PCs) in a feature space is fixed a priori by selecting the appropriate kernel function. Therefore, the objective of this work is to use KPCA and KPLS techniques to monitor nonlinear data. The improved FD performance of KPCA and KPLS is illustrated through two simulated examples, one using synthetic data and the other using simulated continuously stirred tank reactor (CSTR) data. The results demonstrate that both KPCA and KPLS methods are able to provide better detection compared to the linear versions.",signatures:"Mohammed Ziyan Sheriff, Chiranjivi Botre, Majdi Mansouri, Hazem\nNounou, Mohamed Nounou and Mohammad Nazmul Karim",downloadPdfUrl:"/chapter/pdf-download/54400",previewPdfUrl:"/chapter/pdf-preview/54400",authors:[{id:"21281",title:"Prof.",name:"Hazem",surname:"Nounou",slug:"hazem-nounou",fullName:"Hazem Nounou"},{id:"21282",title:"Prof.",name:"Mohamed N.",surname:"Nounou",slug:"mohamed-n.-nounou",fullName:"Mohamed N. Nounou"},{id:"191340",title:"Mr.",name:"M. Ziyan",surname:"Sheriff",slug:"m.-ziyan-sheriff",fullName:"M. Ziyan Sheriff"},{id:"191341",title:"Mr.",name:"Chiranjivi",surname:"Botre",slug:"chiranjivi-botre",fullName:"Chiranjivi Botre"},{id:"191343",title:"Dr.",name:"Majdi",surname:"Mansouri",slug:"majdi-mansouri",fullName:"Majdi Mansouri"},{id:"191345",title:"Prof.",name:"M. Nazmul",surname:"Karim",slug:"m.-nazmul-karim",fullName:"M. Nazmul Karim"}],corrections:null},{id:"55395",title:"Noninvasive Methods for Condition Monitoring and Electrical Fault Diagnosis of Induction Motors",doi:"10.5772/67245",slug:"noninvasive-methods-for-condition-monitoring-and-electrical-fault-diagnosis-of-induction-motors",totalDownloads:1497,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:"This chapter provides a comprehensive analysis of noninvasive methods to diagnose stator winding insulation faults of an induction motor. Further, a novel noninvasive method is proposed to diagnose the root cause of winding failure due to unbalanced voltage to avoid catastrophic failure. Therefore, a winding function approach is utilized to derive an analytical expression for stator winding distribution and magnetomotive force (MMF). This tactic qualifies the conductor segment that generates MMF, and it also helps to analyze a healthy current spectrum. One can easily observe higher order harmonics in current spectrum; therefore, a new series of rotor harmonics is introduced to diagnose unbalanced supply. The locus of these harmonics is dependent on the poles, rotor bars, and slip. Due to the rapid complexity in industrial plants, it is inconceivable to continue human inspection to diagnose the faults. Thus, to avoid human inspection, in addition to new series of rotor harmonic, a fully automatic method based on neural network is proposed. This method not only diagnoses unbalanced voltage but it also recognize the percentage of unbalanced voltage by use of feed-forward multilayer perceptron (MLP) trained by back propagation. Finally, the experimental results shows the validation of this research work proposed method.",signatures:"Muhammad Aman Sheikh, Nursyarizal Mohd Nor, Taib Ibrahim,\nSheikh Tahir Bakhsh, Muhammad Irfan and Hanita Binti Daud",downloadPdfUrl:"/chapter/pdf-download/55395",previewPdfUrl:"/chapter/pdf-preview/55395",authors:[{id:"192401",title:"Dr.",name:"Muhammad Aman",surname:"Sheikh",slug:"muhammad-aman-sheikh",fullName:"Muhammad Aman Sheikh"},{id:"2264",title:"Mr.",name:"Nursyarizal",surname:"Mohd Nor",slug:"nursyarizal-mohd-nor",fullName:"Nursyarizal Mohd Nor"},{id:"193010",title:"Dr.",name:"Taib",surname:"Ibrahim",slug:"taib-ibrahim",fullName:"Taib Ibrahim"}],corrections:null},{id:"54720",title:"Detection and Analysis of Petroleum Equipment Faults",doi:"10.5772/intechopen.68227",slug:"detection-and-analysis-of-petroleum-equipment-faults",totalDownloads:1510,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The method fitness‐for‐service (FFS) provides the means by which the operator of a technical system can decide: It can continue to work safely, reducing of working parameters or stopping the equipment and reparation it. A case study concerning a natural gas pipeline is introduced. It brings some applicative aspects: the introduction of the failure probability as an indicator; the reduction of the degree of conservatism; a maintenance program based on pipeline intelligent gauge.",signatures:"Mihail Minescu and Ion Pana",downloadPdfUrl:"/chapter/pdf-download/54720",previewPdfUrl:"/chapter/pdf-preview/54720",authors:[{id:"194974",title:"Prof.",name:"Minescu",surname:"Mihail",slug:"minescu-mihail",fullName:"Minescu Mihail"},{id:"194975",title:"Prof.",name:"Pana",surname:"Ion",slug:"pana-ion",fullName:"Pana Ion"}],corrections:null},{id:"55233",title:"Automated Fault Detection System for Wind Farms",doi:"10.5772/intechopen.68844",slug:"automated-fault-detection-system-for-wind-farms",totalDownloads:1414,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Due to the pollution and health hazards of nonrenewable resource-based energy generation systems, now focus is on the use of renewable resources. This chapter aims as providing an automated fault-detection system for increasing the robustness of offshore located wind farms. The method is based on the use of flexible threshold for calculation of the collected sample values. A fuzzy inference system (FIS) is designed for the automatic real-time fault detection system named as FIS-based fault detection system (FFDS) for offshore wind farms. The method uses the concept of combination-summation (CS) and flow-directions to determine the extent of fault occurrence in the wind farm. Based on the working conditions of the wind farm, preventive or corrective measures are suggested to the remote observer. The performance of these methods is evaluated on MATLAB.",signatures:"Deepshikha Agarwal",downloadPdfUrl:"/chapter/pdf-download/55233",previewPdfUrl:"/chapter/pdf-preview/55233",authors:[{id:"190942",title:"Dr.",name:"Deepshikha",surname:"Agarwal",slug:"deepshikha-agarwal",fullName:"Deepshikha Agarwal"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"103",title:"Sliding Mode Control",subtitle:null,isOpenForSubmission:!1,hash:"5693e6e3680ceffd1e4f39d81a142db8",slug:"sliding-mode-control",bookSignature:"Andrzej Bartoszewicz",coverURL:"https://cdn.intechopen.com/books/images_new/103.jpg",editedByType:"Edited by",editors:[{id:"18337",title:"Prof.",name:"Andrzej",surname:"Bartoszewicz",slug:"andrzej-bartoszewicz",fullName:"Andrzej Bartoszewicz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"88",title:"Robust Control",subtitle:"Theory and Applications",isOpenForSubmission:!1,hash:"ec78377d126114b991fd47c1e75c30d7",slug:"robust-control-theory-and-applications",bookSignature:"Andrzej Bartoszewicz",coverURL:"https://cdn.intechopen.com/books/images_new/88.jpg",editedByType:"Edited by",editors:[{id:"18337",title:"Prof.",name:"Andrzej",surname:"Bartoszewicz",slug:"andrzej-bartoszewicz",fullName:"Andrzej Bartoszewicz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3688",title:"Systems Structure and Control",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"systems_structure_and_control",bookSignature:"Petr Husek",coverURL:"https://cdn.intechopen.com/books/images_new/3688.jpg",editedByType:"Edited by",editors:[{id:"134681",title:"Prof.",name:"Petr",surname:"Husek",slug:"petr-husek",fullName:"Petr Husek"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2286",title:"Frontiers in Advanced Control Systems",subtitle:null,isOpenForSubmission:!1,hash:"43dae6480e55f2985ce8c4a1860e6dca",slug:"frontiers-in-advanced-control-systems",bookSignature:"Ginalber Luiz de Oliveira Serra",coverURL:"https://cdn.intechopen.com/books/images_new/2286.jpg",editedByType:"Edited by",editors:[{id:"11032",title:"Dr.",name:"Ginalber Luiz",surname:"Serra",slug:"ginalber-luiz-serra",fullName:"Ginalber Luiz Serra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"183",title:"Recent Advances in Robust Control",subtitle:"Theory and Applications in Robotics and Electromechanics",isOpenForSubmission:!1,hash:"a1537e544940ecd76fe2211e50f5881d",slug:"recent-advances-in-robust-control-theory-and-applications-in-robotics-and-electromechanics",bookSignature:"Andreas Mueller",coverURL:"https://cdn.intechopen.com/books/images_new/183.jpg",editedByType:"Edited by",editors:[{id:"30836",title:"Dr.",name:"Andreas",surname:"Müller",slug:"andreas-muller",fullName:"Andreas Müller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"512",title:"Recent Advances in Robust Control",subtitle:"Novel Approaches and Design Methods",isOpenForSubmission:!1,hash:"ec6eec7e1046ed9f47b45c567a69c2f7",slug:"recent-advances-in-robust-control-novel-approaches-and-design-methods",bookSignature:"Andreas Mueller",coverURL:"https://cdn.intechopen.com/books/images_new/512.jpg",editedByType:"Edited by",editors:[{id:"30836",title:"Dr.",name:"Andreas",surname:"Müller",slug:"andreas-muller",fullName:"Andreas Müller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"513",title:"Challenges and Paradigms in Applied Robust Control",subtitle:null,isOpenForSubmission:!1,hash:"dbf6fa81341f15a510fbf598a0539791",slug:"challenges-and-paradigms-in-applied-robust-control",bookSignature:"Andrzej Bartoszewicz",coverURL:"https://cdn.intechopen.com/books/images_new/513.jpg",editedByType:"Edited by",editors:[{id:"18337",title:"Prof.",name:"Andrzej",surname:"Bartoszewicz",slug:"andrzej-bartoszewicz",fullName:"Andrzej Bartoszewicz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1941",title:"Applications of Nonlinear Control",subtitle:null,isOpenForSubmission:!1,hash:"80902b0f516643e79c5d70dffba05722",slug:"applications-of-nonlinear-control",bookSignature:"Meral Altinay",coverURL:"https://cdn.intechopen.com/books/images_new/1941.jpg",editedByType:"Edited by",editors:[{id:"119998",title:"Dr.",name:"Meral",surname:"Altınay",slug:"meral-altinay",fullName:"Meral Altınay"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5823",title:"Recent Developments in Sliding Mode Control",subtitle:"Theory and Applications",isOpenForSubmission:!1,hash:"1075a2f87196085bae2babfac6bc3d52",slug:"recent-developments-in-sliding-mode-control-theory-and-applications",bookSignature:"Andrzej Bartoszewicz",coverURL:"https://cdn.intechopen.com/books/images_new/5823.jpg",editedByType:"Edited by",editors:[{id:"18337",title:"Prof.",name:"Andrzej",surname:"Bartoszewicz",slug:"andrzej-bartoszewicz",fullName:"Andrzej Bartoszewicz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9287",title:"Control Theory in Engineering",subtitle:null,isOpenForSubmission:!1,hash:"7c584de5f40193b636833aa812dab9d5",slug:"control-theory-in-engineering",bookSignature:"Constantin Volosencu, Ali Saghafinia, Xian Du and Sohom Chakrabarty",coverURL:"https://cdn.intechopen.com/books/images_new/9287.jpg",editedByType:"Edited by",editors:[{id:"1063",title:"Prof.",name:"Constantin",surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"65666",slug:"erratum-metrology-organic-solvents-in-the-shoes-industry-to-sfax-city-tunisia",title:"Erratum - Metrology Organic Solvents in the Shoes Industry to Sfax City (Tunisia)",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/65666.pdf",downloadPdfUrl:"/chapter/pdf-download/65666",previewPdfUrl:"/chapter/pdf-preview/65666",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/65666",risUrl:"/chapter/ris/65666",chapter:{id:"62241",slug:"metrology-organic-solvents-in-the-shoes-industry-to-sfax-city-tunisia-",signatures:"Imed Gargouri and Moncef Khadhraoui",dateSubmitted:"October 10th 2017",dateReviewed:"May 4th 2018",datePrePublished:null,datePublished:"January 30th 2019",book:{id:"6671",title:"Paint and Coatings Industry",subtitle:null,fullTitle:"Paint and Coatings Industry",slug:"paint-and-coatings-industry",publishedDate:"January 30th 2019",bookSignature:"Faris Yilmaz",coverURL:"https://cdn.intechopen.com/books/images_new/6671.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"36900",title:"Dr.",name:"Faris",middleName:"Sad",surname:"Yılmaz",slug:"faris-yilmaz",fullName:"Faris Yılmaz"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"186371",title:"Associate Prof.",name:"Imed",middleName:null,surname:"Gargouri",fullName:"Imed Gargouri",slug:"imed-gargouri",email:"imed.gargouri@fmsf.rnu.tn",position:null,institution:{name:"University of Sfax",institutionURL:null,country:{name:"Tunisia"}}},{id:"230836",title:"Dr.",name:"Khadhraoui",middleName:null,surname:"Moncef",fullName:"Khadhraoui Moncef",slug:"khadhraoui-moncef",email:"montunisia@yahoo.com",position:null,institution:null}]}},chapter:{id:"62241",slug:"metrology-organic-solvents-in-the-shoes-industry-to-sfax-city-tunisia-",signatures:"Imed Gargouri and Moncef Khadhraoui",dateSubmitted:"October 10th 2017",dateReviewed:"May 4th 2018",datePrePublished:null,datePublished:"January 30th 2019",book:{id:"6671",title:"Paint and Coatings Industry",subtitle:null,fullTitle:"Paint and Coatings Industry",slug:"paint-and-coatings-industry",publishedDate:"January 30th 2019",bookSignature:"Faris Yilmaz",coverURL:"https://cdn.intechopen.com/books/images_new/6671.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"36900",title:"Dr.",name:"Faris",middleName:"Sad",surname:"Yılmaz",slug:"faris-yilmaz",fullName:"Faris Yılmaz"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"186371",title:"Associate Prof.",name:"Imed",middleName:null,surname:"Gargouri",fullName:"Imed Gargouri",slug:"imed-gargouri",email:"imed.gargouri@fmsf.rnu.tn",position:null,institution:{name:"University of Sfax",institutionURL:null,country:{name:"Tunisia"}}},{id:"230836",title:"Dr.",name:"Khadhraoui",middleName:null,surname:"Moncef",fullName:"Khadhraoui Moncef",slug:"khadhraoui-moncef",email:"montunisia@yahoo.com",position:null,institution:null}]},book:{id:"6671",title:"Paint and Coatings Industry",subtitle:null,fullTitle:"Paint and Coatings Industry",slug:"paint-and-coatings-industry",publishedDate:"January 30th 2019",bookSignature:"Faris Yilmaz",coverURL:"https://cdn.intechopen.com/books/images_new/6671.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"36900",title:"Dr.",name:"Faris",middleName:"Sad",surname:"Yılmaz",slug:"faris-yilmaz",fullName:"Faris Yılmaz"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"7358",leadTitle:null,title:"Cerium Oxide",subtitle:"Applications and Attributes",reviewType:"peer-reviewed",abstract:"This book focuses on the chemical structure and applications of CeO2. It covers the recent developments in a wide range of CeO2 applications, particularly catalysis corrosion protection, fuel cells, sensors, and UV-blocking. It also provides a concise but thorough coverage of the chemical structure and applications of CeO2. Thus, this book provides an overview of chemical structure, applications, and recent attributes of CeO2 for a broad audience, including beginners, graduate students, and specialists in both academic and industrial sectors.",isbn:"978-1-78985-024-6",printIsbn:"978-1-78985-023-9",pdfIsbn:"978-1-83881-820-3",doi:"10.5772/intechopen.75239",price:119,priceEur:129,priceUsd:155,slug:"cerium-oxide-applications-and-attributes",numberOfPages:122,isOpenForSubmission:!1,isSalesforceBook:!1,hash:"7d1cd9a9ecf46270e344d15f94bc66ef",bookSignature:"Sher Bahadar Khan and Kalsoom Akhtar",publishedDate:"January 23rd 2019",coverURL:"https://cdn.intechopen.com/books/images_new/7358.jpg",keywords:null,numberOfDownloads:7640,numberOfWosCitations:17,numberOfCrossrefCitations:7,numberOfDimensionsCitations:23,numberOfTotalCitations:47,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 15th 2018",dateEndSecondStepPublish:"March 8th 2018",dateEndThirdStepPublish:"May 7th 2018",dateEndFourthStepPublish:"July 26th 2018",dateEndFifthStepPublish:"September 24th 2018",remainingDaysToSecondStep:"4 years",secondStepPassed:!0,currentStepOfPublishingProcess:5,editedByType:"Edited by",kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"245468",title:"Dr.",name:"Sher Bahadar",middleName:null,surname:"Khan",slug:"sher-bahadar-khan",fullName:"Sher Bahadar Khan",profilePictureURL:"https://mts.intechopen.com/storage/users/245468/images/system/245468.jpg",biography:"Prof. Dr. Sher Bahadar Khan received his Ph.D from HEJ, Karachi University, Pakistan. After completion of his Ph.D, he started his post-doctoral career in nanochemistry and nanotechnology and continued to work as a post-doctoral research fellow to February 2010 at Yonsei University, South Korea. In March 2010, he joined the Center for Advanced Materials and Nano-engineering, Department of Chemistry, Najran University as an Assistant Professor and continued his work to 31 August 2011. He joined the Chemistry Department, King Abdulaziz University, Jeddah, Saudi Arabia as an Assistant Professor in September 2011. Currently he is Full Professor in the Chemistry Department, King Abdulaziz University and is doing research in nanochemistry and nanotechnology. He was honoured by receiving the top scientist award of KP Science & Technology in 2018. He was also honoured by the Deanship of Scientific Research awards at King Abdulaziz University for book, patent, and highly ranked scientific publication. He is the author of 320 research articles, twelve books, and six patents with almost 1000 ± 10 impact factor, 6665 citations, and 45 h-index.",institutionString:"King Abdulaziz University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"King Abdulaziz University",institutionURL:null,country:{name:"Saudi Arabia"}}}],coeditorOne:{id:"245469",title:"Dr.",name:"Kalsoom",middleName:null,surname:"Akhtar",slug:"kalsoom-akhtar",fullName:"Kalsoom Akhtar",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:"Dr. Kalsoom Akhtar received her Ph.D from the Chemistry Department, Ewha Womans University, Seoul, Korea. Dr. K. Akhtar is an Assist. Professor in the Chemistry Department, King Abdulaziz University and is currently doing research in organic and nano-chemistry, which comprises photo-catalyst, organic synthesis, and metal oxide nanomaterials. She is the author of 2 books and 65 research papers.",institutionString:"King Abdulaziz University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"King Abdulaziz University",institutionURL:null,country:{name:"Saudi Arabia"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"492",title:"Solid-State Chemistry",slug:"chemistry-inorganic-chemistry-solid-state-chemistry"}],chapters:[{id:"64964",title:"Introductory Chapter: Cerium Oxide - Applications and Attributes",slug:"introductory-chapter-cerium-oxide-applications-and-attributes",totalDownloads:1305,totalCrossrefCites:0,authors:[{id:"245468",title:"Dr.",name:"Sher Bahadar",surname:"Khan",slug:"sher-bahadar-khan",fullName:"Sher Bahadar Khan"},{id:"245469",title:"Dr.",name:"Kalsoom",surname:"Akhtar",slug:"kalsoom-akhtar",fullName:"Kalsoom Akhtar"}]},{id:"62281",title:"Extraction and Recovery of Cerium from Rare Earth Ore by Solvent Extraction",slug:"extraction-and-recovery-of-cerium-from-rare-earth-ore-by-solvent-extraction",totalDownloads:1603,totalCrossrefCites:2,authors:[{id:"249818",title:"Mr.",name:"Kai",surname:"Li",slug:"kai-li",fullName:"Kai Li"},{id:"249920",title:"Prof.",name:"Ji",surname:"Chen",slug:"ji-chen",fullName:"Ji Chen"},{id:"258611",title:"Dr.",name:"Dan",surname:"Zou",slug:"dan-zou",fullName:"Dan Zou"}]},{id:"64660",title:"Cerium Oxides for Corrosion Protection of AZ91D Mg Alloy",slug:"cerium-oxides-for-corrosion-protection-of-az91d-mg-alloy",totalDownloads:999,totalCrossrefCites:1,authors:[{id:"249515",title:"Dr.",name:"Ivana L.",surname:"Lehr",slug:"ivana-l.-lehr",fullName:"Ivana L. Lehr"},{id:"249516",title:"Prof.",name:"Silvana",surname:"Saidman",slug:"silvana-saidman",fullName:"Silvana Saidman"},{id:"249517",title:"Ms.",name:"Ana Paula",surname:"Loperena",slug:"ana-paula-loperena",fullName:"Ana Paula Loperena"}]},{id:"62332",title:"Doped Ceria for Solid Oxide Fuel Cells",slug:"doped-ceria-for-solid-oxide-fuel-cells",totalDownloads:1379,totalCrossrefCites:2,authors:[{id:"249568",title:"Prof.",name:"Shobit",surname:"Omar",slug:"shobit-omar",fullName:"Shobit Omar"}]},{id:"64320",title:"Prototyping a Gas Sensors Using CeO2 as a Matrix or Dopant in Oxide Semiconductor Systems",slug:"prototyping-a-gas-sensors-using-ceo2-as-a-matrix-or-dopant-in-oxide-semiconductor-systems",totalDownloads:1341,totalCrossrefCites:1,authors:[{id:"187612",title:"Dr.",name:"Lucian",surname:"Pîslaru-Dănescu",slug:"lucian-pislaru-danescu",fullName:"Lucian Pîslaru-Dănescu"},{id:"189137",title:"Mrs.",name:"Gabriela",surname:"Telipan",slug:"gabriela-telipan",fullName:"Gabriela Telipan"},{id:"250006",title:"Dr.",name:"Ioana",surname:"Ion",slug:"ioana-ion",fullName:"Ioana Ion"},{id:"250007",title:"Mr.",name:"Virgil",surname:"Marinescu",slug:"virgil-marinescu",fullName:"Virgil Marinescu"}]},{id:"63807",title:"Waterborne Acrylic/CeO2 Nanocomposites for UV Blocking Clear Coats",slug:"waterborne-acrylic-ceo2-nanocomposites-for-uv-blocking-clear-coats",totalDownloads:1014,totalCrossrefCites:1,authors:[{id:"249649",title:"Dr.",name:"Miren",surname:"Aguirre",slug:"miren-aguirre",fullName:"Miren Aguirre"},{id:"259520",title:"Dr.",name:"María",surname:"Paulis",slug:"maria-paulis",fullName:"María Paulis"},{id:"259521",title:"Prof.",name:"Jose R.",surname:"Leiza",slug:"jose-r.-leiza",fullName:"Jose R. Leiza"}]}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"220812",firstName:"Lada",lastName:"Bozic",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/220812/images/6021_n.jpg",email:"lada@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"7478",title:"Photocatalysts",subtitle:"Applications and Attributes",isOpenForSubmission:!1,hash:"26559479998a0a8d83546de0a220c87f",slug:"photocatalysts-applications-and-attributes",bookSignature:"Sher Bahadar Khan and Kalsoom Akhtar",coverURL:"https://cdn.intechopen.com/books/images_new/7478.jpg",editedByType:"Edited by",editors:[{id:"245468",title:"Dr.",name:"Sher Bahadar",surname:"Khan",slug:"sher-bahadar-khan",fullName:"Sher Bahadar Khan"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8724",title:"Gas Sensors",subtitle:null,isOpenForSubmission:!1,hash:"bc4be4b954b559709aaace45f70adcd0",slug:"gas-sensors",bookSignature:"Sher Bahadar Khan, Abdullah M. Asiri and Kalsoom Akhtar",coverURL:"https://cdn.intechopen.com/books/images_new/8724.jpg",editedByType:"Edited by",editors:[{id:"245468",title:"Dr.",name:"Sher Bahadar",surname:"Khan",slug:"sher-bahadar-khan",fullName:"Sher Bahadar Khan"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2283",title:"Advances in Crystallization Processes",subtitle:null,isOpenForSubmission:!1,hash:"fbac03612cea22d52fd05bd8ebace89c",slug:"advances-in-crystallization-processes",bookSignature:"Yitzhak Mastai",coverURL:"https://cdn.intechopen.com/books/images_new/2283.jpg",editedByType:"Edited by",editors:[{id:"41724",title:"Prof.",name:"Yitzhak",surname:"Mastai",slug:"yitzhak-mastai",fullName:"Yitzhak Mastai"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1980",title:"Crystallization",subtitle:"Science and Technology",isOpenForSubmission:!1,hash:"b512238b6bad61510871f4871c41dafe",slug:"crystallization-science-and-technology",bookSignature:"Marcello Rubens Barsi Andreeta",coverURL:"https://cdn.intechopen.com/books/images_new/1980.jpg",editedByType:"Edited by",editors:[{id:"114928",title:"Dr.",name:"Marcello",surname:"Andreeta",slug:"marcello-andreeta",fullName:"Marcello Andreeta"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"914",title:"Current Trends in X-Ray Crystallography",subtitle:null,isOpenForSubmission:!1,hash:"3affdb143c8dd481536ecb0531969cc0",slug:"current-trends-in-x-ray-crystallography",bookSignature:"Annamalai Chandrasekaran",coverURL:"https://cdn.intechopen.com/books/images_new/914.jpg",editedByType:"Edited by",editors:[{id:"72043",title:"Dr.",name:"Annamalai",surname:"Chandrasekaran",slug:"annamalai-chandrasekaran",fullName:"Annamalai Chandrasekaran"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6407",title:"Application of Titanium Dioxide",subtitle:null,isOpenForSubmission:!1,hash:"fdb4aecdbffe5d2f4415d8b36d71143d",slug:"application-of-titanium-dioxide",bookSignature:"Magdalena Janus",coverURL:"https://cdn.intechopen.com/books/images_new/6407.jpg",editedByType:"Edited by",editors:[{id:"199458",title:"Dr.",name:"Magdalena",surname:"Janus",slug:"magdalena-janus",fullName:"Magdalena Janus"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5211",title:"Chemical Vapor Deposition",subtitle:"Recent Advances and Applications in Optical, Solar Cells and Solid State Devices",isOpenForSubmission:!1,hash:"dc03fdc6ad1c27ebfcb54e337cbf03ce",slug:"chemical-vapor-deposition-recent-advances-and-applications-in-optical-solar-cells-and-solid-state-devices",bookSignature:"Sudheer Neralla",coverURL:"https://cdn.intechopen.com/books/images_new/5211.jpg",editedByType:"Edited by",editors:[{id:"128532",title:null,name:"Sudheer",surname:"Neralla",slug:"sudheer-neralla",fullName:"Sudheer Neralla"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4531",title:"Advanced Topics in Crystallization",subtitle:null,isOpenForSubmission:!1,hash:"c1b75a72987c71a8eb02ddb014b99882",slug:"advanced-topics-in-crystallization",bookSignature:"Yitzhak Mastai",coverURL:"https://cdn.intechopen.com/books/images_new/4531.jpg",editedByType:"Edited by",editors:[{id:"41724",title:"Prof.",name:"Yitzhak",surname:"Mastai",slug:"yitzhak-mastai",fullName:"Yitzhak Mastai"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4783",title:"Apatites and their Synthetic Analogues",subtitle:"Synthesis, Structure, Properties and Applications",isOpenForSubmission:!1,hash:"d435b3984fa4d5d2d6921679511fe384",slug:"apatites-and-their-synthetic-analogues-synthesis-structure-properties-and-applications",bookSignature:"Petr Ptacek",coverURL:"https://cdn.intechopen.com/books/images_new/4783.jpg",editedByType:"Authored by",editors:[{id:"76186",title:"Associate Prof.",name:"Petr",surname:"Ptáček",slug:"petr-ptacek",fullName:"Petr Ptáček"}],productType:{id:"3",chapterContentType:"chapter",authoredCaption:"Authored by"}},{type:"book",id:"5985",title:"Titanium Dioxide",subtitle:null,isOpenForSubmission:!1,hash:"5d5a07758249f9e02ca1b83ee1f8efef",slug:"titanium-dioxide",bookSignature:"Magdalena Janus",coverURL:"https://cdn.intechopen.com/books/images_new/5985.jpg",editedByType:"Edited by",editors:[{id:"199458",title:"Dr.",name:"Magdalena",surname:"Janus",slug:"magdalena-janus",fullName:"Magdalena Janus"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"40533",title:"Probabilistic Evaluation of the Extent of the Aquifer – Case Study",doi:"10.5772/32904",slug:"probabilistic-evaluation-of-the-extent-of-the-aquifer-case-study",body:'Environmental researchers often analyze phenomena and objects which can be determined as “poorly-defined” (Fisher 1999). Due to mathematical rules of sets these are the objects which are difficult to be assigned to a specific class of objects in compliance with dichotomic rules of binary (Aristotelian) logic. The extents of lithofacial, stratygraphical and tectonic units are represented in the cartographic studies based on the point or local reconnaissance performed in the field. With respect to distances, those limits are of probable course, more or less similar to the natural boundary. Error assessment of graphic presentation of the geological units has not been expressed in values yet. There is even a lack of approximate estimation of probability to define the unit borders. A similar problem can be identified in hydrogeology. There we have to evaluate homogenic areas and units with similar properties of groundwaters or aquifers. Hydrogeologic cartography offers diversified studies, due to the credibility of used data. It directly finds reflection in the accuracy and likelihood of estimation of the extent of groundwater bodies, their amounts and quality.
In environmental researches, the proper use of the information (or the lack of the information) leads to searching for way to represent this kind of data. It is argued (Leung & Leung, 1993) that the application of Boolean logic (the all-or-nothing system) in the GIS design causes the following problems: a) it imposes artificial precision on intrinsically imprecise information, graded spatial phenomena and processes, b) it fails to determine and communicate to users the extent of imprecision and error, c) it is inappropriate to human cognition, perception and thinking processes, which are generally embedded with imprecision (Leung & Leung 1993).
The aquifer is a good illustration of a “poorly-defined” object (fig. 1). This result from the lack of information on its extent (especially for the confined aquifer), facies changes within the aquifer and various definitions of the aquifer.
Example of “poorly-defined” objects: limits of forest, valley and aquifer
In order to describe correctly “poorly-defined” objects in modeling proper methods should be found. They should allow intermediate values to be defined between conventional evaluations like 1 and 0, true or false. For describing “poorly-defined” objects we can use one of the multi-valued logic such as “fuzzy logic” (Zadeh, 1965), kernel-based probability density function estimation (Brundson, 1995) or other probability methods such as Bayesian theory or Dempster – Shafer theory (Shafer, 1976; Klir and Yuan 1997; Eastman 1999b). This paper attempts to evaluate the extent of the unconfined aquifer in a nonparametric – probabilistic scale with help of last one.
The main study objective was to evaluate the probability that an unconfined aquifer may be found in each pixel location in a surface represented in the studied area. Due to a large amount of data IDRISI software was used to achieve the aim.
The research area of 1300 km2 in the east part of the Pomeranian Lakeland in Poland was chosen for a testing procedure. This area lies completely within the limits of the last (Veichselian) glaciation. Along with the relatively slight hypsometric differentiation, the relief of the studied area is characterized by a few forms of fluvioglacial and glacial source. The main form is outwash sediments (the Wda sandur) and a moraine plateau (Fig. 2).
Location of the study site
There are only Cenozoic water bearing strata recognized within the log wells. The Pleistocene water bearing layers are the major aquifer for the studied area. It consists from of the unconfined aquifer and a few confined aquifers (Fig. 3).
The (hydro)geologic recognition of research area is rather shallow and diversified due to uninhabited area. These is shown on the Fig. 4\n\t\t\t
Geologic cross-section along line A-A’ in
Map of depth of geologic recognition of the research area.
The Dempster-Shafer theory (Shafer, 1976) is an extension of Bayesian probability theory. This theory makes a distinction between probability and ignorance and allows for the expression of ignorance in uncertainty management (Lee et al., 1987; Klir & Yuan, 1995). The basic assumption of Dempster-Shafer theory are that ignorance exists in the body of knowledge, and that the belief for hypothesis is not necessary to the complement of the belief for its negation. By using the “belief functions” to represent the uncertainty of hypothesis, the theory releases some of the axioms of probability theory. The resulting system becomes a superclass of probability theory. However, it suffers from the need for large numbers of probability assignments and from the need for independence assumptions (Malczewski, 1999). Unlike Bayesian probability analysis, D-S theory explicitly recognizes the possibility of ignorance in the evaluation, i.e. the incompleteness of knowledge or evidence in the hypothesis (Eastman, 1999).
The research objective was performed on IDRISI (ver. Andes) raster based software program. In IDRISI, the BELIEF module (Fig. 8) can be used to implement the Dempster-Shafer theory. BELIEF constructs and stores the current state of knowledge for the full hierarchy of hypotheses formed from a frame of discernment (also called state space). BELIEF first requires that the basic elements in the frame of discernment be defined. As soon as the basic elements are entered, all hypotheses in the hierarchical structure will be created in the hypothesis list. For each line of evidence entered, basic probability assignment images (in the form of real number images with a 0 – 1 range) are required with an indication of their supported hypothesis.
The research question guides us to define the frame of discernment – it includes two elements [present] and [absent]. The hierarchical combination of all possible hypotheses, therefore, includes [present], [absent] and [present, absent]. We are most interested in the result generated for the hypothesis [present]. The final results produced for the hypothesis [present] are dependent on how all evidences are related together in the process of aggregation.
Given knowledge about existing wells and given expert knowledge about the occurrences of aquifers, each evidence is transformed into a layer representing likelihood that a aquifer exists. The aggregated evidence produces results that are used to predict the presence of an aquifer and evaluate the impact of each line of evidence to the total body of knowledge.
For study several bitmaps and pixel maps were prepared. At the beginning each map included separately: point, line or area data which all confirm or deny the occurrence of the aquifer in a dichotomy scale 0 and 1. In the next stage, the information on each map was changed due to the prepared membership function. As a result, the pixel map with values from 0 to 1 was obtained. Finally, all the maps (information layers) were put to the BELIEF module and probability map was compute.
There is significant difference between analyzing the extent of the unconfined or confined aquifer with the use of the GIS methods. With the exception of the wells as the best indicator of existing aquifers, there is far more indirect evidence of occurrences for the unconfined aquifer than the first one. For example, they are: springs, rivers, lakes, the area of extent of alluvial or outwash deposits. There is high probability that the unconfined aquifer will be close to these forms (Kachnic, 2010).
The author focused here only on the unconfined aquifer. Still, GIS methods are a tool for, by and large, two dimensional data. And there is no advanced GIS raster program for analyzing three dimensional data yet, required for analyzing the confined aquifer.
For estimating the extent of the unconfined aquifer in a probabilistic scale the following data was selected:
locations of wells and boreholes,
area of the extent of the outwash and moraine plateau,
course of main rivers and lakes,
map of depth to the water table in the area where there are no impermeable sediments on the terrain surface.
The stage of fuzzyfication is a procedure, which allows for converting a discrete image (bitmap) into images with a probabilistic (nonparametric) scale. The reliability of the obtained maps depends on the applied parameters of fuzzyfication controlled by a membership function. For researches the following assumptions were taken:
Initially, for the whole research area the background value was assumed as constant 0.5. That means there is no proof for the existing of unconfined aquifer and there isn’t evidence for the lack of the aquifer in research area.
Wells are the best point markers of the aquifer. For these features, the area in the close vicinity of the wells obtained high likehood. The map with locations of the wells with unconfined conditions were rasterised and all the pixels where there were wells, obtained the value “one”. The pixel values are high in the area calculated by means of empirical formula, and finally, the pixel value decreased down to the level of the background (Fig. 5).
The empirical formula was applied as one of the assumptions for the extent of the unconfined aquifer. That was a formula:
known as the Kusakin formula (Bear, 1979; Hölting, 1996).
Where R – is a radius in [m] of depression cone; s – the maximum depression observed in a well [m], k – the coefficient of permeability, in [m/24h] and H – thickness of the aquifer in the well log, [m].
Graph of the membership function for wells in an unconfined aquifer.
The Kusakin formula isn’t good assumption for extend of aquifer and should be established the better one.
The value “0” was assigned for the pixels where boreholes exist and there is not unconfined aquifer noticed. In the vicinity of those pixels, probability increases from “0” to the value of background for the range 300 [m] (Fig. 6). The above distance was established subjectively as the optimal one after analyzing the geological and hydrogeological cross-section from the research area.
Graph of the membership function for boreholes and wells without unconfined aquifer.
The value “1” was assigned for the pixels where boreholes exist and there is an unconfined aquifer notice. In the vicinity of those pixels, probability increases from “1” to the value of background for the range 300 [m].
In the research area the main body of the unconfined aquifer is associated with fluvioglacial outwash (a sandur). The area of the outwash extent was digitized from the Geological Map of Poland in a scale 1:200 000 (Butrymowicz et al., 1978). The rest of the area was classified as a logic negation, which means the area without sand sediments on the terrain surface (i.e. moraine plateau). The value “0.8” was assigned to all the pixels which represent the area of outwash sediments and the river valley (Fig. 2). For the remaining area a constant value “0.3” was established
Graph of the membership function for area of outwash and moraine plateau.
Rivers and lakes are hydrologic objects with frequent connection to the aquifer, especially the unconfined aquifer. Close to a river or a lake there are often sand sediments with the aquifer, therefore, this closeness to water indicates the plausibility for the aquifer. Only rivers that are longer than 5 km and lakes with the area bigger than 1 ha were analyzed.
Simple statistical methods were used in order to develop the relationship between the distance to water and the locations of the wells. On the basis of that procedure the author found that there should be higher likelihood (the value of 0.8) in the zone 200 [m] from the river banks or lake shores (Fig. 8).
The information about the depth to the water table and the extent of the unit “a” where there are no impermeable sediments on the terrain surface, was taken from the computer Hydrogeological Map of Poland in a scale 1:50 000 (HMofP). HMofP is a new kind of a map, prepared and stored in GIS (Geomedia) system as a multisheet map (Paczyński et al., 1999). From 1994 to 2004, 1069 sheets covering the whole of Poland were made. The map is based on the concept of the main usable aquifer which is a productive aquifer meeting the following criteria: thickness at least 5 m, transmissivity at least 50 m3/24h, and potential discharge of a well at least 10 m3/h. All data is kept in 19 information vector layers, which contain among others: topographic situation, well and spring locations, type of the aquifer, water quality classes, aquifers pollution risk classes, land use and hydrodynamic information, e.g. hydraulic head, groundwater flow directions and transmissivity distribution (Herbich, 2005; Fert et al., 2005).
Graph of the membership function for hydrological objects.
All prepared pixel maps were put to the BELIEF module (Fig. 9).
The window of BELIEF module of IDRISI program.
After processing in the BELIEF module a set of maps was generated. These were maps of the degree to which evidence provided concrete support for the hypothesis (belief) (Fig. 9) and the degree to which that evidence did not refute the hypothesis (plausibility).
The probabilistic map of the extent of the unconfined aquifer in a research area.
The limits of geological and hydrogeological units (structure) presented on the cartographic studies include often significant errors due to poor of recognition. Those errors are highest in the area recognized by drilling holes, i.e. point recognition.
The purpose of the methodology presented herein is to produce a probabilistic information layer of the extent of the unconfined aquifer in the studied area (Fig. 10). It is an attempt to use Dempster-Shafer theory in hydrogeology. Taking into account the fuzzy set theory, the author proposed the assessment of hydrogeological structure extent based upon hydrogeological boreholes where pumping test had been carried out.
Additional information for the probabilistic map come from hydrological, geomorphological investigations and data from other geological reconnaissance point. The accuracy of such map is largely determined by the reliability of database information and established membership functions.
The author treat the generated maps as a supplement to a classic set of information concerning hydrogeology and which provides a new form of a map layer which can be useful for decision-makers. The statistical description of the pixel value on the result map may be used for the assessment of reliability of groundwater model and as decision support for sustainable groundwater management.
Cardiovascular disease is the leading cause of death in men and women in the United States and throughout the world [1]. Current efforts are focused on decreasing the burden of death due to atherosclerosis and cardiac disease overall. Increased attention has been placed on the activation of the renin-angiotensin-aldosterone system (RAAS) and pathogenetic mechanisms in cardiovascular disease. The RAAS system effects blood pressure control and electrolyte and fluid balance and therefore plays a significant role in cardiovascular hemodynamics [2, 3, 4].
Classically, it is known that angiotensinogen is cleaved by renin to form angiotensin-I (Ang I), which is then converted to angiotensin-II (Ang II) by angiotensin converting enzyme (ACE), however other peptides and products of this axis have been shown to play a role in the development of cardiovascular disease [3, 4]. It is thought that two of these products (angiotensin 1-7 and angiotensin 1-9) may have counterregulatory effects on the development of atherosclerosis and cardiovascular disease [4]. Although the role of angiotensin II is understood more clearly, these peptides provide other targets by which the RAAS system can be utilized to prevent atherosclerosis.
Overactivation or pathologic activation of the RAAS system, specifically angiotensin II, has been shown to play a specific role in endothelial dysfunction, inflammation, intense vasoconstriction, increased vascular and cardiac hypertrophy, fibrosis and the development of atherosclerosis [2, 3, 4, 5]. Multiple large investigations have shown that direct inhibition of the effects of angiotensin II via angiotensin converting enzyme inhibitors (ACE-I) and angiotensin-receptor blockers (ARB) improve mortality, prevent renal disease and decrease cardiovascular events in this subset of patients. Additionally, some studies have shown that utilization of both ARB and ACE-I may have cumulative effects on inhibiting the adverse effects of an overactivated RAAS system [6, 7].
We aim to highlight the known role of the activated RAAS and provide an updated description of the mechanisms by which overactivation of RAAS promotes disease and provide a summary of the clinical implications of RAAS inhibition in cardiovascular disease.
The RAAS system has several moving parts, with different organ systems stimulating its activation and suppression. Renin, the active form of prorenin, is secreted by the granular cells of the kidney. Although renin’s role is that of an enzyme, its means of expression are more hormonal. Renin’s production is stimulated by hypotension, hyponatremia, and decreased sympathetic activity. Renin is responsible for cleaving angiotensinogen, a protein produced in the liver. Angiotensinogen is regulated via thyroid hormone, steroids, and levels of circulating angiotensin II. Angiotensinogen is cleaved into angiotensin I, which is further converted into angiotensin II by angiotensin converting enzyme [3, 4].
RAAS key players are composed of renin, angiotensin I & II, and angiotensin converting enzyme located in the heart atria, conduction system, valves, ventricles, coronary vessels, fibroblasts and myocytes [8, 9]. Ang II is the effector hormone playing a pivotal role in the cardiac RAAS and has a widespread effect throughout the body, targeting different mechanisms of action.
Ang II acts via the angiotensin receptors mediating the following actions [9, 10]:
Cardiovascular system - vasoconstriction, increased blood pressure, increased cardiac contractility, vascular and cardiac hypertrophy
Renal system - tubular sodium reabsorption, inhibition of renin release
Sympathetic nervous system stimulation
Aldosterone synthesis through adrenal cortex
Cell growth and proliferation, inflammatory response, and oxidative stress.
Angiotensin converting enzyme 2 (ACE 2) is involved in the degradation of Ang II to Ang (1-7) and Ang (1-9), which provide a relative vasodilatory effect as outlined in Figure 1. ACE 2 is restricted to vascular endothelial cells, arterial smooth muscle cells, myofibroblasts, carotid arteries and renal tubular epithelium [8, 9, 10]. The effects of Ang II, Ang (1-7) and Ang (1-9) have been uncovered in the past several years, specifically their role in hypertension, endothelial damage, and cardiovascular disease [5, 6, 9, 12]. The role of Ang (1-7) and Ang (1-9) is further outlined in Figure 1 as they pertain to the pathophysiologic changes in the cardiovascular system.
Schematic of the RAAS as it pertains to angiotensin II and angiotensin (1-7) (Ang-(1-7)) and their counter-regulatory effects via angiotensin receptors 1 and 2 (AT1-R and AT2-R respectively) and MAS receptor (MAS) [
Endothelial dysfunction is thought to be a precursor to atherosclerosis, or the thickening and stiffness of vessels. This damage often cultivates in an atherosclerotic plaque, which is a fibrin and cholesterol contained structure that deposits on the inner lumen of blood vessels and can impede oxygen delivery to tissues and organs. Endothelial damage and inflammation allow for the migration of monocytes and macrophages to the site of injury and the formation of foam cells [13, 14, 15]. Additionally, stimulation of inflammatory mediators also promotes smooth muscle cell (SMC) thickening, stiffness of vessels and forms a fibrous cap on the atherosclerotic plaque (Figure 2) [16]. The pathophysiology of plaque development is very closely tied to RAAS as Ang II plays a key role in these pathophysiologic changes.
A schematic depicting the dynamic changes involved in the formation of an atherosclerotic plaque [
Ang II acts on the AT1 and AT2 receptors (AT1-R and AT2-R) causing arteriolar vasoconstriction, and inflammation through generation of reactive oxygen species (ROS), proinflammatory transcription factors such as nuclear factor kB (nf-kB), and the proliferation of smooth muscle cells contributing to atherogenesis [17, 18]. Activated nf-kB increases inflammatory mediators including interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1) and platelet derived growth factor (PDGF), all of which mediate inflammation, endothelial damage and monocyte migration and adhesion leading to fibrosis [6, 18].
Ang II induces NF-kappaB (NF-kB) and inflammation through its binding to AT1-R. This has been demonstrated extensively as AT1-R blockers have shown to significantly decrease inflammation. Induction of NF-kB leads to the expression of pro-inflammatory cytokines such as IL-6 and TNF-alpha [19, 20]. Additionally, IL-6 itself can activate AT1-R resulting in overexpression and production of reactive oxidative species (ROS) when RAAS is overstimulated [19]. The RAAS is also a potent oxidant stimulator, as it activates the NADH/NADPH oxidase signaling pathway, and thereby produces superoxide anions and other ROS. TNF-alpha impairs endothelial nitric oxide (NO) production in coronary arteries thereby causing vasoconstriction. Additionally, ACE plays a role in the degradation of bradykinin, which depletes NO formation as well [6, 18, 19, 20]. Overall, we have a RAAS mediated expression of ROS, inflammatory mediators, and depletion of vasodilatory NO.
This inflammation mediated cellular injury and production of ROS, activates the endothelium and increases expression of intercellular adhesion molecules (ICAM-1) and vascular cell adhesion molecules (VCAM-1), which promote endothelial damage and make cells leaky [9, 21, 22]. The endothelial damage promotes further migration of leukocytes, production of inflammatory cytokines and chemokines.
Finally, RAAS promotes thrombosis through Ang II receptors located on human platelets. Through these receptors Ang II promotes the release of thromboxane A2 and platelet derived growth factor, which promote atherosclerotic plaque formation and thrombus formation [22, 23]. Ang II involvement in endothelial dysfunction and atherosclerotic plaque formation is summarized in Figure 3.
Summarized effects of Ang II as it is known to cause endothelial damage, inflammation, migration and adhesion of monocytes, proliferation of vasculature and platelets and formation of atherosclerotic plaque and thrombus [
Hypertension, defined as a systolic blood pressure greater than 120 and diastolic pressure greater than 80, affects a quarter of the world’s population. When the etiology of hypertension is unknown, it is termed essential hypertension. When the cause of hypertension is known, by way of underlying metabolic, hormonal, neurogenic, or cardiovascular dysfunction, it is deemed as secondary hypertension [24]. As we have reviewed thus far, RAAS is responsible for maintaining sodium concentration in the blood, fluid status, and hemodynamic stability and therefore has a significant effect on blood pressure. Overactivation of RAAS can perpetuate unwanted elevations in blood pressure.
Increased levels of Ang II and subsequently aldosterone cause increases in vascular tone and hypertension. Aldosterone, a mineralocorticoid, takes its effect by binding to mineralocorticoid receptors (MR) and translocating into nucleus. Here, it integrates with cellular DNA and induces transcription of genes that regulate electrolytes and fluid balance. An over expression of aldosterone causes an elevated aldosterone-renin ratio which leads to systemic complications [4].
Patient’s with primary aldosteronism (PA) and increased aldosterone levels are at higher risk for cerebrovascular complications. Although PA is not a common diagnosis, fifteen percent of patients with essential hypertension have higher than normal levels of circulating aldosterone. We can conclude that this sub-set of essential hypertension patients will have similar end-organ effects of elevated aldosterone as do patients with PA [4].
Hypertension itself can cause endovascular injury, which leads to increased production of ROS and inflammatory mediators ultimately contributing to atherosclerosis [25, 26]. The result of such endothelial injury is worsening cardiovascular disease, hypertension, and renal dysfunction. We see this manifest in the kidney with proteinuria and collagen deposition. Eventually, healthy kidney parenchyma is replaced with fibrotic tissue, leading to even more dysregulation with blood pressure homeostasis. In the cardiovascular system, inflammatory damage from overactivation of RAAS and hypertension causes calcifications and fibrosis. As such, inhibition of the RAAS system with ACE-I and ARB has become a cornerstone in therapy for hypertensive patients, particularly those with evidence of diabetes, microalbuminuria and in CAD patients overall [15, 25, 26, 27, 28]. The details of some of the landmark clinical trials contributing to the guidelines in treatment with ACE-I and ARB are further discussed in this chapter.
Coronary artery disease (CAD) or Ischemic heart disease (IHD), develops when there is a limitation of blood flow within the coronaries. It occurs due to the gradual buildup of atherosclerotic plaque within the wall of arteries leading to reduced oxygen delivery to cardiac myocytes. It comprises a clinical spectrum based on the degree of luminal narrowing and the activation of the atherosclerotic plaque [13, 14]. The RAAS plays a vital role in the pathogenesis of CAD. Evidence supports that RAAS controls atherosclerosis through intracellular signaling pathways by mediating endothelial function, inflammation, fibrinolytic balance, growth, lipid-glucose metabolism, and its vasoconstrictor function.
Ang II has growth promoting effects by regulating growth of vascular smooth muscle cells and activating the growth associated kinase pathways. In states of ischemia, there is increased vascular endothelial growth factor (VEGF) expression. In vascular smooth muscle cells, transforming growth factor B1, platelet derived growth factor causes fibrosis and cellular hypertrophy. These angiogenic factors lead to the formation of new cells, fibrin, and collagen deposition leading to growth of the plaque and thickening of vessels [20, 21].
RAAS plays a role in altering the fibrinolytic balance as well by inhibiting fibrinolysis and enhancing thrombosis. Within the vessels, Ang II stimulates the release of plasminogen activator inhibitor - I (PAI-I) thereby reducing the fibrinolytic activity. It activates tissue factor which acts as a cofactor for factor VII, potentiating the coagulation cascade [22, 23]. The above mechanism increases the thrombogenic activity.
Ang II overexpression causes endothelial inflammation and activation of cytokine cascade thereby causing progression of atherosclerotic plaque. The silent plaque ruptures when the inflammation overwhelms the stable fibrous cap causing thrombosis and acute ischemia [13, 14].
Heart failure is a clinical syndrome categorized based on clinical signs and symptoms and further subclassified by echocardiography findings. As per the American College of Cardiology, left ventricular ejection fraction (LVEF) of ≥50% is defined as heart failure with preserved ejection fraction (HFpEF), LVEF 41-49% as heart failure with mid-range ejection fraction (HFmrEF), LVEF≤40% as heart failure with reduced ejection fraction (HFrEF). HFrEF particularly occurs after an inciting event like myocardial injury, arrhythmias, cardiomyopathies, substance abuse, infections or genetic diseases which put the heart in a state of stress leading to contractile dysfunction and cellular remodeling [29]. The circulatory changes arising from heart failure are sensed by the peripheral baroreceptors and chemoreceptors, thereby activating a sequalae of compensatory neurohormonal mechanisms. The compensatory mechanisms include activation of sympathetic nervous system (SNS) and RAAS. RAAS plays an integral role in cardiac contractility, homeostatic control of blood pressure and electrolyte-fluid balance [30, 31].
In an adult with normal circulation, the baroreceptors located in the carotid sinus and aortic arch balance the sympathetic and parasympathetic outflow from the central nervous system. Alterations in the cardiac output change the effective arterial blood volume resulting in inhibition of parasympathetic response and a reflux increase in the sympathetic vascular tone. The increased sympathetic activity leads to vasoconstriction of the renal afferent arteriole and decreases blood flow to the kidney [29, 32]. This activates renin secretion and thereby RAAS.
Renin is secreted in response to 4 main stimuli [10, 33]:
Decreased renal perfusion pressure sensed by baroreceptor cells in the arterial vessel wall
Decreased intracellular chloride levels (altered NaCl delivery)
Sympathetic nerve stimulation via beta-1 adrenergic receptors
Negative feedback by a direct action of Ang II
The pathophysiology of heart failure allows for decreased renal perfusion and increased sympathetic response, both of which cause an overactivation of the RAAS [34]. The overstimulation of RAAS in heart failure is further depicted in Figure 4.
The regulatory effects of RAAS as it pertains to heart failure mechanics [
In pathological states like pressure or volume overload, cardiac tissues exhibit elevated levels of renin and Ang II levels leading to cardiac hypertrophy, myocardial fibrosis, hypertensive heart disease and chronic heart failure through mechanics explained earlier. Additionally, post-infarction levels of ACE-2 have been shown to be elevated, which may explain a counter-regulatory mechanism to protect against the Ang-II mediated myocardial damage. When this natural counter-regulatory mechanism is lost in ACE-2 knockout animal models the levels of dilated cardiomyopathy were much more pronounced. Several trials have also looked at specific levels of plasma renin and HFrEF and have found that those with elevated levels had an associated worse outcome than their counterparts. In patients with advanced heart failure, baseline levels of plasma renin and plasma aldosterone are persistently high, which further exemplifies the role of RAAS in cardiac remodeling and heart failure [35, 36, 37].
Innovative studies have discovered that a particular breakdown product of Ang 1-7, also known as Alamandine, has shown to prevent ventricular and vascular remodeling in animal models [11]. Studies of by-products offer areas of potential research as we grow to understand the intricacies of the molecular pathways that play a role in the development of heart failure.
The overactivation of RAAS and its effects on the pathophysiology of hypertension, vascular stiffness, ischemia, thrombosis, and left ventricular (LV) remodeling has been well documented. As such, several medications that impede the harmful effects of the overactivation of RAAS have been shown to prevent the negative clinical outcomes. Here we review some of the landmark clinical trials that have contributed to the current guidelines and recommendations for the treatment of hypertension, ischemic heart disease and heart failure (Table 1).
Trial Name (Date) | Primary/ Secondary Outcomes | Inclusion Criteria | Intervention | Number of Patients /Follow-up Time | Results |
---|---|---|---|---|---|
Rate of eGFR change, progression of CKD or all-cause mortality | AA, Age 18-70, DBP >95 mmHg, HTN renal Disease, eGFR 20-65 | BP control – with ramipril, amlodipine or metoprolol | 1,094/4 years | No difference in progression of CKD. Use of ACE-I associated with fewer CKD events or death | |
6 Month Mortality | NYHA IV HFrEF, optimal treatment with at least diuretic and digitalis or other medications (nitrates, prazosin, hydralazine) | Enalapril VS placebo | 253/6-20 months (about 1 and a half years) | Six-month mortality with enalapril was 26% as opposed to 44% with placebo | |
All-cause mortality, CV death, Death due to MI, Death due to stroke | HF, LVEF <35%, Receiving conventional therapy without ACE-I | Enalapril VS placebo | 2,569/3.5 years | Enalapril reduces 4-year mortality by 16% and reduces HF hospitalizations | |
2-year mortality, hemodynamic effects, EF, exercise tolerance, adherence | Men ages 18-75, reduced exercise tolerance, cardiac dysfunction, receiving optimal and stable therapy | Enalapril. VS ISDN/ hydralazine | 804 men/2.5 years | Enalapril improved survival compared to combination of ISDN and hydralazine | |
All-cause mortality | Age over 21 years, MI in prior 3 days, new onset LVEF less than 40%, absence of overt signs of CHF | Captopril VS placebo | 2,231/42 months (about 3 and a half years) | In patients with acute MI complicated by low EF, captopril led to 19% reduction in all-cause mortality | |
All-cause mortality | Age > 18 years, Acute MI within prior 10 days complicated by HF, LVEF <35% on echocardiogram or < 40% on radionucleotide ventriculography | Valsartan VS valsartan + captopril VS captopril | 14,703/ 24 months (about 2 years) | Valsartan was as effective as captopril in improving survival | |
All-cause mortality | 50 years of age or older with confirmed acute MI and HF in acute phase or a new Q-wave anterior infarction or reinfarction | Losartan VS captopril | 5,477/2.7 years | No significant change in mortality between the two drugs, however losartan was better tolerated | |
Cardiovascular death or HF admission | LVEF>40%, NYHA class II-IV symptoms for at least 4 weeks, history of at least one cardiac hospitalization | Candesartan VS placebo | 3,020/3 years | Candesartan modestly reduced the rate of HF-related hospitalizations. No effect on CV mortality | |
Death from any cause, hospitalization for CV disease | 40 years of age or older and had NYHA class II-IV and an EF of at least 45% | Irbesartan VS placebo | 4,128/49 months | Irbesartan did not improve mortality in patients with HFpEF | |
CV mortality or HF hospitalizations | Age > 18 years, LVEF<40% in prior 6 months, NYHA II-IV, treatment with stable ACE-I dose for >30 days | Candesartan VS placebo | 2,548/ 41 months | Addition of candesartan reduced CV mortality of HF hospitalization | |
All-cause mortality, cardiac arrest with resuscitation, HF hospitalization | Age > 18 years, NYHA II-IV, receipt of a fixed dose of medical therapy (ACE, digoxin, diuretics, and/or BB) for >2 weeks, EF < 40% | Valsartan VS placebo | 5,010/23 months (about 2 years) | In a time where HF management included ACE but not BB, addition of ARB decreased HF hospitalizations | |
CV mortality, MI, stroke, HF hospitalization | Age over 55 years with CAD, PAD, CV disease or high-risk DM | Telmisartan VS Ramipril VS Telmisartan and Ramipril | 25,620/56 months (about 4 and a half years) | Patients with CV disease or DM with complications telmisartan was as good as Ramipril in preventing death, MI, and stroke. The combination of both however had no increase in benefit and was associated with more adverse events. | |
All-cause mortality | NYHA IV within 6 months to enrollment, NYHA III or IV at the time of enrolment, treatment with ACE and a loop diuretic, LVEF <35% | Spironolactone VS placebo | 1,663/2 years | Spironolactone led to 30% reduction in all-cause mortality without significant side-effects | |
CV mortality, aborted cardiac arrest, or HF hospitalization | Age > 50 years, LVEF >45%, SBP <140 or < 160 if on 3 anti-hypertensives, serum potassium <5, elevated BNP in last 60 days, or HF hospitalization in last 12 months | Spironolactone VS placebo | 3,445/3 years | Spironolactone did not reduce CV mortality however did result in a small reduction in HF hospitalizations | |
CV death or hospitalization, all-cause mortality, fatal or non-fatal MI | Age > 55 years, NYHA II, EF < 30%, treatment with ACE, ARB or both, treatment with BB, CV hospitalization in last 6 months | Eplerenone VS placebo | 2,737/21 months (about 2 years) | Eplerenone reduces the risk of death and hospitalization in patients with low EF and NYHA II | |
CV mortality or HF hospitalization | Age > 18 years, NYHA class II-IV, EF <35%, if no HF hospitalizations in last year BNP >150 pg./mL, ACE, or ARB and BB with stable dose, If HF hospitalization in last year BNP >100 pg./mL | ARNI VS enalapril | 8,399/27 months (about 2 and a half years) | ARNI reduces CV mortality or HF hospitalizations when compared to enalapril. Also reduces all-cause mortality | |
HF hospitalizations and CV mortality, change in NYHA class at 8 months, all-cause mortality | >50 years of age, LVEF>45%, NYHA II-IV, and at least one of the following: HF hospitalization with NT-proBNP>200 (no AFIB) or > 600 (AFIB) or NT-proBNP>300 (no AFIB) or > 900 (Afib) on screening visit ECG | ARNI VS valsartan alone | 4,822/35 months (about 3 years) | ARNI did not lower hospitalizations or death from CV causes, however there was a modest improvement in NYHA class and a slower decline in renal function than what was seen in valsartan alone | |
Time-averaged change in NT-proBNP concentration from baseline through weeks 4-8 | Age > 18 years, LVEF<40%, NT-proBNP of 1600 pg./mL or more, or BNP of 400 pg./mL or more, receiving diagnosis of acute decompensated HF up to10 days after presentation | ARNI versus enalapril | 881/2 years | ARNI decreased NT-proBNP compared to enalapril therapy without significant change in rate of adverse events | |
Death from CV causes, nonfatal MI, nonfatal stroke, ESRD, death attributable to kidney failure, or the need for RRT | 35 years or older with type 2 diabetes and evidence of microalbuminuria, macroalbuminuria, or cardiovascular disease | Aliskiren VS placebo | 8,561/32 months (about 2 and a half years) | The addition of aliskiren to standard therapy in patients with type 2 diabetes who are at elevated risk for CV and renal events is potentially harmful |
Trials documenting improvement in cardiovascular outcomes and reduced cardiovascular mortality with renin-angiotensin-aldosterone system inhibition.
Summarized landmark clinical trials depicting the benefits of RAAS inhibition in cardiac and renal patients.
In the treatment of hypertension, the patient’s specific co-morbidities must be considered prior to initiating therapy including, race, diabetes, kidney function and other high-risk pre-existing conditions that may predispose to CV outcomes. One landmark trial, the AASK trial (2002), studied African Americans with hypertension and kidney disease and compared intensive blood pressure control versus conservative blood pressure control with ACE-I, metoprolol, and amlodipine. The two groups had no difference in the progression to CKD, however patients on ACE-I had less chronic kidney disease events and death, which solidified the use of ACE-I in patients with CKD [38].
The mainstay of treatment in patients with heart failure and CAD is blockade of the RAAS. Multiple trials highlighted in Table 1 have been performed showing improvement in cardiovascular (CV) outcomes and reduced CV mortality.
The first trial to demonstrate improved CV outcomes with HFrEF is the CONSENSUS (1987) trial conducted among New York Heart Association (NYHA) Class IV HF and cardiomegaly patients which compared enalapril and placebo. Six-month mortality with enalapril was 26% as opposed to 44% with placebo [39]. The SOLVD (1991) treatment trial chose patients with HF and LVEF ≤35%, NYHA II-IV, with similar randomization, showing mortality reduction by 16% due to reduction of death in patients on enalapril versus placebo. This study also showed a decrease in CV related hospitalizations [40]. Further research with the V-HeFT II (1991) trial showed that ACE-I was superior in improving survival to vasodilators such as isosorbide dinitrate and hydralazine [41]. Additionally, use of ACE-I as a disease modifying drug was established post-MI in the SAVE trial (1992), which is further discussed in Table 1 [42].
Additional studies looked to compare the effects of ACE-I versus ARB. These trials were the VALIANT (2003) trial and the OPTIMAAL (2002) trial. The VALIANT trial showed that valsartan was as effective as captopril in improving survival among patients with HF and/or LV disfunction in the post-MI period [43]. The OPTIMAAL trial compared losartan and captopril in high-risk patients after acute myocardial infarction with LV-dysfunction and heart failure and found no difference in mortality outcomes [44]. Similar studies in patients with HFpEF were conducted, including the CHARM-Preserved trial (2003) and the I-PRESERVE trial (2008). CHARM- Preserved showed that candesartan modestly reduced HF-related hospitalizations however had no effect on mortality [45]. I-PRESERVE used Irbesartan in HFpEF patients and similarly found no reduction in mortality [46].
The thought that the addition of an ARB to an ACE inhibitor could inhibit RAAS more significantly was established. This was compared in two large significant trials. The CHARM-added trial compared symptomatic HF patients with LVEF ≤40% who were already on an ACE inhibitor with either addition of candesartan or placebo. This trial showed a reduction in CV mortality and HF hospitalizations; however, it was accompanied by a significant increase in hyperkalemic events [47]. The Val-HeFT (2001) compared patients with symptomatic HF, LVEF <40% with LV dilatation and on ACE inhibitors by adding either valsartan or placebo. There was no effect on mortality however, there was a 23% reduction in HF hospitalization in the treatment group [48]. Finally, the ONTARGET trial (2008) compared ramipril to telmisartan to a combination of both in patients with CV disease or diabetes with complications and found that the combination of telmisartan plus ramipril had no increase in benefit and was associated with more adverse events [49].
Several trials looking at the effects of aldosterone antagonists and heart failure patients were conducted with overall favorable results. Patients benefit from reduced sympathetic stimulation and alleviate fluid overload from sodium and water retention through aldosterone blockade. The RALES trial (1999) studied the role of spironolactone in patients with LVEF≤35% and NYHA class III-IV, which showed that Spironolactone, along with ACE-I (as most patients were already on ACE-I) showed a 11% reduction in CV mortality compared to placebo [50]. The TOPCAT trial (2014) done in patients with HFpEF and controlled blood pressures to receive spironolactone or placebo. This study conversely showed that spironolactone did not reduce CV mortality however did result in a small reduction in HF hospitalizations [51]. Another trial, the EMPHASIS-HF trial (2011), looked at Eplerenone versus placebo in HF patients, NYHA class II, showed that Eplerenone reduced the risk of death and hospitalizations in patients with HF [52].
A newer group of RAAS inhibition medications combining an ARB and neprilysin inhibitor (ARNI) was studied in 2014 in the PARADIGM-HF trial. Neprilysins are key enzymes in the degradation of natriuretic peptides. They increase endogenous natriuretic peptide levels including bradykinin, thereby promoting vasodilation and natriuresis. Neprilysins were initially attempted with an ACE inhibitor combination however this led to incidences of angioedema given increased levels of bradykinin. PARADIGM - HF trial was conducted in patients with symptomatic HF and LVEF ≤40% assigned to enalapril alone or valsartan-sacubitril combination. This showed significant reduction in CV mortality, all-cause mortality, and HF hospitalizations with no increase in angioedema events [53]. The PARAGON-HF trial (2019) studied ARNI versus valsartan alone in HFpEF patients with EF > 45% and NYHA II to IV and showed that ARNI did not lower hospitalizations or death from CV causes, however there was a modest improvement in NYHA class and a slower decline in renal function than what was seen in valsartan alone [54]. The PIONEER-HF trial (2019) showed that initiated of ARNI versus enalapril in acute diastolic heart failure patients allowed for significant reductions in HF biomarker, NT-proBNP, without significant change in adverse effects [55].
Direct renin inhibitors have been attempted with the goal of reducing renin and thereby the entire RAAS cascade. The ALTITUDE trial (2012) added aliskiren to patients with diabetes type 2 in order to prevent kidney disease and CV outcomes. These patients were on ACE-I however the addition of aliskiren led to an increase in CV mortality, hypotension, and adverse hyperkalemic events. The trial was stopped early due to higher mortality findings [56].
RAAS is a complex and evolving pathway that has been implicated in the pathogenesis of endothelial damage, atherosclerosis, and cardiac remodeling. Inhibition of the negative effects of overactivated RAAS has shown to cause morbidity and mortality benefits in cardiovascular disease outcomes. Significant research has yet to be performed on the possibility of stimulating the counter-regulatory effects of RAAS through AT2-R and MAS-R. Such mechanisms are still being studied in animal models; however, the effects of AT2-R and MAS-R offer potential areas of continued research and potential targets for future therapy.
No conflicts of interest exist for this work by any of the authors.
You have been successfully unsubscribed.
",metaTitle:"Unsubscribe Successful",metaDescription:"You have been successfully unsubscribed.",metaKeywords:null,canonicalURL:"/page/unsubscribe-successful",contentRaw:'[{"type":"htmlEditorComponent","content":""}]'},components:[{type:"htmlEditorComponent",content:""}]},successStories:{items:[]},authorsAndEditors:{filterParams:{sort:"featured,name"},profiles:[],filtersByRegion:[],offset:0,limit:12,total:null},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"1",sort:"dateEndThirdStepPublish",topicId:"19,16"},books:[{type:"book",id:"11254",title:"Optical Coherence Tomography",subtitle:null,isOpenForSubmission:!0,hash:"a958c09ceaab1fc44c1dd0a817f48c92",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11254.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11588",title:"Autism",subtitle:null,isOpenForSubmission:!0,hash:"0c5043c6174db167599cb3f762e8bba8",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11588.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11694",title:"Preterm Birth",subtitle:null,isOpenForSubmission:!0,hash:"32122a528d743d1f8843ac6b1c9cd564",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11694.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11697",title:"Scoliosis",subtitle:null,isOpenForSubmission:!0,hash:"fa052443744b8f6ba5a87091e373bafe",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11697.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11699",title:"Neonatal Surgery",subtitle:null,isOpenForSubmission:!0,hash:"e52adaee8e54f51c2ba4972daeb410f7",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11699.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11713",title:"Chiropractic Medicine",subtitle:null,isOpenForSubmission:!0,hash:"b4e556ae0275a66d0c662a53aac5cb92",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11713.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11727",title:"Bronchitis",subtitle:null,isOpenForSubmission:!0,hash:"bde0bf7ccc8a2c1798f43ab5b56d338c",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11727.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11730",title:"Midwifery",subtitle:null,isOpenForSubmission:!0,hash:"95389fcd878d0e929234c441744ba398",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11730.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11818",title:"Uveitis",subtitle:null,isOpenForSubmission:!0,hash:"f8c178e6f45ba7b500281005b5d5b67a",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11818.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11838",title:"Football Science",subtitle:null,isOpenForSubmission:!0,hash:"e69975f96f195be8093194346f8bbe58",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11838.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11843",title:"Abortion Access",subtitle:null,isOpenForSubmission:!0,hash:"e07ed1706ed2bf6ad56aa7399d9edf1a",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11843.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11850",title:"Systemic Sclerosis",subtitle:null,isOpenForSubmission:!0,hash:"df3f380c5949c8d8c977631cac330f67",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11850.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:41},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:12},{group:"topic",caption:"Business, Management and Economics",value:7,count:7},{group:"topic",caption:"Chemistry",value:8,count:17},{group:"topic",caption:"Computer and Information Science",value:9,count:18},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:18},{group:"topic",caption:"Engineering",value:11,count:44},{group:"topic",caption:"Environmental Sciences",value:12,count:7},{group:"topic",caption:"Immunology and Microbiology",value:13,count:11},{group:"topic",caption:"Materials Science",value:14,count:13},{group:"topic",caption:"Mathematics",value:15,count:6},{group:"topic",caption:"Medicine",value:16,count:106},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:2},{group:"topic",caption:"Neuroscience",value:18,count:7},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:11},{group:"topic",caption:"Physics",value:20,count:4},{group:"topic",caption:"Psychology",value:21,count:8},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:32},{group:"topic",caption:"Technology",value:24,count:1},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:2}],offset:12,limit:12,total:117},popularBooks:{featuredBooks:[{type:"book",id:"10584",title:"Engineered Wood Products for Construction",subtitle:null,isOpenForSubmission:!1,hash:"421757c56a3735986055250821275a51",slug:"engineered-wood-products-for-construction",bookSignature:"Meng Gong",coverURL:"https://cdn.intechopen.com/books/images_new/10584.jpg",editors:[{id:"274242",title:"Dr.",name:"Meng",middleName:null,surname:"Gong",slug:"meng-gong",fullName:"Meng Gong"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10222",title:"Demyelination Disorders",subtitle:null,isOpenForSubmission:!1,hash:"b6c26ceccacdde70c41c587361bd5558",slug:"demyelination-disorders",bookSignature:"Stavros J. Baloyannis, Fabian H. Rossi and Welwin Liu",coverURL:"https://cdn.intechopen.com/books/images_new/10222.jpg",editors:[{id:"156098",title:"Emeritus Prof.",name:"Stavros J.",middleName:"J.",surname:"Baloyannis",slug:"stavros-j.-baloyannis",fullName:"Stavros J. Baloyannis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9544",title:"Global Trade in the Emerging Business Environment",subtitle:null,isOpenForSubmission:!1,hash:"fb8cb09b9599246add78d508a98273d5",slug:"global-trade-in-the-emerging-business-environment",bookSignature:"Muhammad Mohiuddin, Jingbin Wang , Md. Samim Al Azad and Selim Ahmed",coverURL:"https://cdn.intechopen.com/books/images_new/9544.jpg",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10979",title:"Parenting",subtitle:"Challenges of Child Rearing in a Changing Society",isOpenForSubmission:!1,hash:"6f345ebcf4fd61e73643c69063a12c7b",slug:"parenting-challenges-of-child-rearing-in-a-changing-society",bookSignature:"Sayyed Ali Samadi",coverURL:"https://cdn.intechopen.com/books/images_new/10979.jpg",editors:[{id:"52145",title:"Dr.",name:"Sayyed Ali",middleName:null,surname:"Samadi",slug:"sayyed-ali-samadi",fullName:"Sayyed Ali Samadi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9808",title:"Contemporary Topics in Patient Safety",subtitle:"Volume 1",isOpenForSubmission:!1,hash:"fb6371607c2c6c02c6a2af8892765aba",slug:"contemporary-topics-in-patient-safety-volume-1",bookSignature:"Stanislaw P. Stawicki and Michael S. Firstenberg",coverURL:"https://cdn.intechopen.com/books/images_new/9808.jpg",editors:[{id:"181694",title:"Dr.",name:"Stanislaw P.",middleName:null,surname:"Stawicki",slug:"stanislaw-p.-stawicki",fullName:"Stanislaw P. Stawicki"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10681",title:"Biodegradation Technology of Organic and Inorganic Pollutants",subtitle:null,isOpenForSubmission:!1,hash:"9a6e10e02788092872fd249436898e97",slug:"biodegradation-technology-of-organic-and-inorganic-pollutants",bookSignature:"Kassio Ferreira Mendes, Rodrigo Nogueira de Sousa and Kamila Cabral Mielke",coverURL:"https://cdn.intechopen.com/books/images_new/10681.jpg",editors:[{id:"197720",title:"Ph.D.",name:"Kassio",middleName:null,surname:"Ferreira Mendes",slug:"kassio-ferreira-mendes",fullName:"Kassio Ferreira Mendes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10764",title:"Antenna Systems",subtitle:null,isOpenForSubmission:!1,hash:"2fbf1c7a5d92723f08198fc9b526a8ad",slug:"antenna-systems",bookSignature:"Hussain Al-Rizzo and Said Abushamleh",coverURL:"https://cdn.intechopen.com/books/images_new/10764.jpg",editors:[{id:"153384",title:"Prof.",name:"Hussain",middleName:null,surname:"Al-Rizzo",slug:"hussain-al-rizzo",fullName:"Hussain Al-Rizzo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10668",title:"Sustainability of Concrete With Synthetic and Recycled Aggregates",subtitle:null,isOpenForSubmission:!1,hash:"55856c6a8bc3a5b21dae5a1af09a56b6",slug:"sustainability-of-concrete-with-synthetic-and-recycled-aggregates",bookSignature:"Hosam M. Saleh",coverURL:"https://cdn.intechopen.com/books/images_new/10668.jpg",editors:[{id:"144691",title:"Prof.",name:"Hosam",middleName:null,surname:"Saleh",slug:"hosam-saleh",fullName:"Hosam Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10803",title:"Reactive Oxygen Species",subtitle:null,isOpenForSubmission:!1,hash:"176adcf090fdd1f93cb8ce3146e79ca1",slug:"reactive-oxygen-species",bookSignature:"Rizwan Ahmad",coverURL:"https://cdn.intechopen.com/books/images_new/10803.jpg",editors:[{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9032",title:"Corporate Social Responsibility",subtitle:null,isOpenForSubmission:!1,hash:"f609bf3251d7cc7bae0099a4374adfc3",slug:"corporate-social-responsibility",bookSignature:"Beatrice Orlando",coverURL:"https://cdn.intechopen.com/books/images_new/9032.jpg",editors:[{id:"232969",title:"Prof.",name:"Beatrice",middleName:null,surname:"Orlando",slug:"beatrice-orlando",fullName:"Beatrice Orlando"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10351",title:"Enhanced Liposuction",subtitle:"New Perspectives and Techniques",isOpenForSubmission:!1,hash:"f08ed6de16da357614586c5b58ed4dfa",slug:"enhanced-liposuction-new-perspectives-and-techniques",bookSignature:"Diane Irvine Duncan",coverURL:"https://cdn.intechopen.com/books/images_new/10351.jpg",editors:[{id:"279869",title:"Dr.",name:"Diane Irvine",middleName:null,surname:"Duncan",slug:"diane-irvine-duncan",fullName:"Diane Irvine Duncan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10779",title:"21st Century Nanostructured Materials",subtitle:"Physics, Chemistry, Classification, and Emerging Applications in Industry, Biomedicine, and Agriculture",isOpenForSubmission:!1,hash:"72c67f97f9bef68200df115b5fd79884",slug:"21st-century-nanostructured-materials-physics-chemistry-classification-and-emerging-applications-in-industry-biomedicine-and-agriculture",bookSignature:"Phuong V. Pham",coverURL:"https://cdn.intechopen.com/books/images_new/10779.jpg",editors:[{id:"236073",title:"Dr.",name:"Phuong",middleName:"Viet",surname:"Pham",slug:"phuong-pham",fullName:"Phuong Pham"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4389},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",publishedDate:"May 18th 2022",numberOfDownloads:3340,editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11001",title:"Density Functional Theory",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"82d53383af78ab41eb982086c02fb2bb",slug:"density-functional-theory-recent-advances-new-perspectives-and-applications",bookSignature:"Daniel Glossman-Mitnik",coverURL:"https://cdn.intechopen.com/books/images_new/11001.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1845,editors:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1096,editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",publishedDate:"May 18th 2022",numberOfDownloads:995,editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",publishedDate:"May 11th 2022",numberOfDownloads:3791,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11752",title:"Natural Drugs from Plants",subtitle:null,isOpenForSubmission:!1,hash:"a0a83c0822608ef7592bf16a5ed0ada4",slug:"natural-drugs-from-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",publishedDate:"May 11th 2022",numberOfDownloads:2982,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",publishedDate:"May 18th 2022",numberOfDownloads:559,editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",publishedDate:"May 18th 2022",numberOfDownloads:546,editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",publishedDate:"May 18th 2022",numberOfDownloads:539,editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",publishedDate:"May 18th 2022",numberOfDownloads:535,editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10871",title:"Computed-Tomography (CT) Scan",subtitle:null,isOpenForSubmission:!1,hash:"966d8cf74fa27eea1b9cbc9a6ee94993",slug:"computed-tomography-ct-scan",bookSignature:"Reda R. Gharieb",coverURL:"https://cdn.intechopen.com/books/images_new/10871.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. Gharieb"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10654",title:"Brain-Computer Interface",subtitle:null,isOpenForSubmission:!1,hash:"a5308884068cc53ed31c6baba756857f",slug:"brain-computer-interface",bookSignature:"Vahid Asadpour",coverURL:"https://cdn.intechopen.com/books/images_new/10654.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11196",title:"New Updates in E-Learning",subtitle:null,isOpenForSubmission:!1,hash:"6afaadf68e2a0a4b370ac5ceb5ca89c6",slug:"new-updates-in-e-learning",bookSignature:"Eduard Babulak",coverURL:"https://cdn.intechopen.com/books/images_new/11196.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"10086",title:"Prof.",name:"Eduard",middleName:null,surname:"Babulak",slug:"eduard-babulak",fullName:"Eduard Babulak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"564",title:"Ubiquitous Computing",slug:"ubiquitous-computing",parent:{id:"90",title:"Computer Science and Engineering",slug:"computer-science-and-engineering"},numberOfBooks:1,numberOfSeries:0,numberOfAuthorsAndEditors:42,numberOfWosCitations:74,numberOfCrossrefCitations:50,numberOfDimensionsCitations:106,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"564",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"116",title:"Advances in Computer Science and Engineering",subtitle:null,isOpenForSubmission:!1,hash:"897d50d8b6fb91d0957ce38776069702",slug:"advances-in-computer-science-and-engineering",bookSignature:"Matthias Schmidt",coverURL:"https://cdn.intechopen.com/books/images_new/116.jpg",editedByType:"Edited by",editors:[{id:"21289",title:"Dr.",name:"Matthias",middleName:null,surname:"Schmidt",slug:"matthias-schmidt",fullName:"Matthias Schmidt"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:1,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"14397",doi:"10.5772/15529",title:"Understanding Virtual Reality Technology: Advances and Applications",slug:"understanding-virtual-reality-technology-advances-and-applications",totalDownloads:3380,totalCrossrefCites:6,totalDimensionsCites:30,abstract:null,book:{id:"116",slug:"advances-in-computer-science-and-engineering",title:"Advances in Computer Science and Engineering",fullTitle:"Advances in Computer Science and Engineering"},signatures:"Moses Okechukwu Onyesolu and Felista Udoka Eze",authors:[{id:"21147",title:"Prof.",name:"Moses",middleName:"Okechukwu",surname:"Onyesolu",slug:"moses-onyesolu",fullName:"Moses Onyesolu"},{id:"24832",title:"Mr.",name:"Felista Udoka",middleName:null,surname:"Eze",slug:"felista-udoka-eze",fullName:"Felista Udoka Eze"}]},{id:"14403",doi:"10.5772/15662",title:"Longitudinal Vibration of Isotropic Solid Rods: From Classical to Modern Theories",slug:"longitudinal-vibration-of-isotropic-solid-rods-from-classical-to-modern-theories",totalDownloads:4879,totalCrossrefCites:8,totalDimensionsCites:21,abstract:null,book:{id:"116",slug:"advances-in-computer-science-and-engineering",title:"Advances in Computer Science and Engineering",fullTitle:"Advances in Computer Science and Engineering"},signatures:"Michael Shatalov, Julian Marais, Igor Fedotov and Michel Djouosseu Tenkam",authors:[{id:"8202",title:"Dr.",name:"Michael",middleName:null,surname:"Shatalov",slug:"michael-shatalov",fullName:"Michael Shatalov"}]},{id:"14405",doi:"10.5772/16062",title:"Estimation of Space Air Change Rates and CO2 Generation Rates for Mechanically-Ventilated Buildings",slug:"estimation-of-space-air-change-rates-and-co2-generation-rates-for-mechanically-ventilated-buildings",totalDownloads:2759,totalCrossrefCites:7,totalDimensionsCites:13,abstract:null,book:{id:"116",slug:"advances-in-computer-science-and-engineering",title:"Advances in Computer Science and Engineering",fullTitle:"Advances in Computer Science and Engineering"},signatures:"Xiaoshu Lu, Tao Lu and Martti Viljanen",authors:[{id:"2657",title:"Dr.",name:"Xiaoshu",middleName:null,surname:"Lu",slug:"xiaoshu-lu",fullName:"Xiaoshu Lu"},{id:"23028",title:"M.Sc",name:"Tao",middleName:null,surname:"Lu",slug:"tao-lu",fullName:"Tao Lu"},{id:"23029",title:"Prof.",name:"Martti",middleName:null,surname:"Viljanen",slug:"martti-viljanen",fullName:"Martti Viljanen"}]},{id:"14402",doi:"10.5772/15313",title:"Mathematical Modelling and Simulation of Pneumatic Systems",slug:"mathematical-modelling-and-simulation-of-pneumatic-systems",totalDownloads:4819,totalCrossrefCites:4,totalDimensionsCites:9,abstract:null,book:{id:"116",slug:"advances-in-computer-science-and-engineering",title:"Advances in Computer Science and Engineering",fullTitle:"Advances in Computer Science and Engineering"},signatures:"Djordje Dihovicni and Miroslav Medenica",authors:[{id:"20314",title:"Dr.",name:"Djordje",middleName:null,surname:"Dihovicni",slug:"djordje-dihovicni",fullName:"Djordje Dihovicni"},{id:"20315",title:"Dr.",name:"Miroslav",middleName:null,surname:"Medenica",slug:"miroslav-medenica",fullName:"Miroslav Medenica"}]},{id:"14406",doi:"10.5772/16025",title:"Decontamination of Solid and Powder Foodstuffs using DIC Technology",slug:"decontamination-of-solid-and-powder-foodstuffs-using-dic-technology",totalDownloads:4037,totalCrossrefCites:5,totalDimensionsCites:8,abstract:null,book:{id:"116",slug:"advances-in-computer-science-and-engineering",title:"Advances in Computer Science and Engineering",fullTitle:"Advances in Computer Science and Engineering"},signatures:"Tamara Allaf, Colette Besombes, Ismail Mih, Laurent Lefevre and Karim Allaf",authors:[{id:"22910",title:"Prof.",name:"Abdul Karim Salim",middleName:null,surname:"Allaf",slug:"abdul-karim-salim-allaf",fullName:"Abdul Karim Salim Allaf"},{id:"22911",title:"Ms.",name:"Tamara",middleName:null,surname:"Allaf",slug:"tamara-allaf",fullName:"Tamara Allaf"},{id:"24143",title:"Ms.",name:"Colette",middleName:null,surname:"Besombes",slug:"colette-besombes",fullName:"Colette Besombes"},{id:"24144",title:"Mr.",name:"Ismail",middleName:null,surname:"Mih",slug:"ismail-mih",fullName:"Ismail Mih"},{id:"24145",title:"Prof.",name:"Laurent",middleName:null,surname:"Lefevre",slug:"laurent-lefevre",fullName:"Laurent Lefevre"}]}],mostDownloadedChaptersLast30Days:[{id:"14409",title:"How to Prove Period-Doubling Bifurcations Existence for Systems of any Dimension - Applications in Electronics and Thermal Field",slug:"how-to-prove-period-doubling-bifurcations-existence-for-systems-of-any-dimension-applications-in-ele",totalDownloads:3891,totalCrossrefCites:0,totalDimensionsCites:1,abstract:null,book:{id:"116",slug:"advances-in-computer-science-and-engineering",title:"Advances in Computer Science and Engineering",fullTitle:"Advances in Computer Science and Engineering"},signatures:"Céline Gauthier-Quémard",authors:[{id:"19422",title:"Dr.",name:"Céline",middleName:null,surname:"Gauthier-Quémard",slug:"celine-gauthier-quemard",fullName:"Céline Gauthier-Quémard"}]},{id:"14394",title:"Next Generation Self-learning Style in Pervasive Computing Environments",slug:"next-generation-self-learning-style-in-pervasive-computing-environments",totalDownloads:2304,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"116",slug:"advances-in-computer-science-and-engineering",title:"Advances in Computer Science and Engineering",fullTitle:"Advances in Computer Science and Engineering"},signatures:"Kaoru Ota, Mianxiong Dong, Long Zheng, Jun Ma, Li Li, Daqiang Zhang and Minyi Guo",authors:[{id:"18150",title:"Dr.",name:"Mianxiong",middleName:null,surname:"Dong",slug:"mianxiong-dong",fullName:"Mianxiong Dong"}]},{id:"14401",title:"Object Oriented Modeling of Rotating Electrical Machines",slug:"object-oriented-modeling-of-rotating-electrical-machines",totalDownloads:3435,totalCrossrefCites:4,totalDimensionsCites:4,abstract:null,book:{id:"116",slug:"advances-in-computer-science-and-engineering",title:"Advances in Computer Science and Engineering",fullTitle:"Advances in Computer Science and Engineering"},signatures:"Christian Kral and Anton Haumer",authors:[{id:"2951",title:"Dr.",name:"Christian",middleName:null,surname:"Kral",slug:"christian-kral",fullName:"Christian Kral"},{id:"22442",title:"Mr.",name:"Anton",middleName:null,surname:"Haumer",slug:"anton-haumer",fullName:"Anton Haumer"}]},{id:"14406",title:"Decontamination of Solid and Powder Foodstuffs using DIC Technology",slug:"decontamination-of-solid-and-powder-foodstuffs-using-dic-technology",totalDownloads:4037,totalCrossrefCites:5,totalDimensionsCites:8,abstract:null,book:{id:"116",slug:"advances-in-computer-science-and-engineering",title:"Advances in Computer Science and Engineering",fullTitle:"Advances in Computer Science and Engineering"},signatures:"Tamara Allaf, Colette Besombes, Ismail Mih, Laurent Lefevre and Karim Allaf",authors:[{id:"22910",title:"Prof.",name:"Abdul Karim Salim",middleName:null,surname:"Allaf",slug:"abdul-karim-salim-allaf",fullName:"Abdul Karim Salim Allaf"},{id:"22911",title:"Ms.",name:"Tamara",middleName:null,surname:"Allaf",slug:"tamara-allaf",fullName:"Tamara Allaf"},{id:"24143",title:"Ms.",name:"Colette",middleName:null,surname:"Besombes",slug:"colette-besombes",fullName:"Colette Besombes"},{id:"24144",title:"Mr.",name:"Ismail",middleName:null,surname:"Mih",slug:"ismail-mih",fullName:"Ismail Mih"},{id:"24145",title:"Prof.",name:"Laurent",middleName:null,surname:"Lefevre",slug:"laurent-lefevre",fullName:"Laurent Lefevre"}]},{id:"14411",title:"New Approach to a Tourist Navigation System that Promotes Interaction with Environment",slug:"new-approach-to-a-tourist-navigation-system-that-promotes-interaction-with-environment",totalDownloads:1873,totalCrossrefCites:2,totalDimensionsCites:2,abstract:null,book:{id:"116",slug:"advances-in-computer-science-and-engineering",title:"Advances in Computer Science and Engineering",fullTitle:"Advances in Computer Science and Engineering"},signatures:"Yoshio Nakatani, Ken Tanaka and Kanako Ichikawa",authors:[{id:"21327",title:"Dr.",name:"Yoshio",middleName:null,surname:"Nakatani",slug:"yoshio-nakatani",fullName:"Yoshio Nakatani"}]}],onlineFirstChaptersFilter:{topicId:"564",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188",scope:"This series will provide a comprehensive overview of recent research trends in various Infectious Diseases (as per the most recent Baltimore classification). Topics will include general overviews of infections, immunopathology, diagnosis, treatment, epidemiology, etiology, and current clinical recommendations for managing infectious diseases. Ongoing issues, recent advances, and future diagnostic approaches and therapeutic strategies will also be discussed. This book series will focus on various aspects and properties of infectious diseases whose deep understanding is essential for safeguarding the human race from losing resources and economies due to pathogens.",coverUrl:"https://cdn.intechopen.com/series/covers/6.jpg",latestPublicationDate:"May 19th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:13,editor:{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"3",title:"Bacterial Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/3.jpg",isOpenForSubmission:!1,editor:null,editorTwo:null,editorThree:null},{id:"4",title:"Fungal Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",isOpenForSubmission:!0,editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. Board Member and Chair of Mycology Group of Chinese Society of Dermatology.",institutionString:null,institution:{name:"Sichuan University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"5",title:"Parasitic Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",isOpenForSubmission:!0,editor:{id:"67907",title:"Dr.",name:"Amidou",middleName:null,surname:"Samie",slug:"amidou-samie",fullName:"Amidou Samie",profilePictureURL:"https://mts.intechopen.com/storage/users/67907/images/system/67907.jpg",biography:"Dr. Amidou Samie is an Associate Professor of Microbiology at the University of Venda, in South Africa, where he graduated for his PhD in May 2008. He joined the Department of Microbiology the same year and has been giving lectures on topics covering parasitology, immunology, molecular biology and industrial microbiology. He is currently a rated researcher by the National Research Foundation of South Africa at category C2. He has published widely in the field of infectious diseases and has overseen several MSc’s and PhDs. His research activities mostly cover topics on infectious diseases from epidemiology to control. His particular interest lies in the study of intestinal protozoan parasites and opportunistic infections among HIV patients as well as the potential impact of childhood diarrhoea on growth and child development. He also conducts research on water-borne diseases and water quality and is involved in the evaluation of point-of-use water treatment technologies using silver and copper nanoparticles in collaboration with the University of Virginia, USA. He also studies the use of medicinal plants for the control of infectious diseases as well as antimicrobial drug resistance.",institutionString:null,institution:{name:"University of Venda",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},{id:"6",title:"Viral Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",isOpenForSubmission:!0,editor:{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:4,paginationItems:[{id:"81821",title:"Pneumococcal Carriage in Jordanian Children and the Importance of Vaccination",doi:"10.5772/intechopen.104999",signatures:"Adnan Al-Lahham",slug:"pneumococcal-carriage-in-jordanian-children-and-the-importance-of-vaccination",totalDownloads:0,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Streptococcal Infections",coverURL:"https://cdn.intechopen.com/books/images_new/10828.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}},{id:"81813",title:"Schistosomiasis: Discovery of New Molecules for Disease Treatment and Vaccine Development",doi:"10.5772/intechopen.104738",signatures:"Andressa Barban do Patrocinio",slug:"schistosomiasis-discovery-of-new-molecules-for-disease-treatment-and-vaccine-development",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"New Horizons for Schistosomiasis Research",coverURL:"https://cdn.intechopen.com/books/images_new/10829.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"81644",title:"Perspective Chapter: Ethics of Using Placebo Controlled Trials for Covid-19 Vaccine Development in Vulnerable Populations",doi:"10.5772/intechopen.104776",signatures:"Lesley Burgess, Jurie Jordaan and Matthew Wilson",slug:"perspective-chapter-ethics-of-using-placebo-controlled-trials-for-covid-19-vaccine-development-in-vu",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"80546",title:"Streptococcal Skin and Skin-Structure Infections",doi:"10.5772/intechopen.102894",signatures:"Alwyn Rapose",slug:"streptococcal-skin-and-skin-structure-infections",totalDownloads:48,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Streptococcal Infections",coverURL:"https://cdn.intechopen.com/books/images_new/10828.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}}]},overviewPagePublishedBooks:{paginationCount:13,paginationItems:[{type:"book",id:"6667",title:"Influenza",subtitle:"Therapeutics and Challenges",coverURL:"https://cdn.intechopen.com/books/images_new/6667.jpg",slug:"influenza-therapeutics-and-challenges",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"105e347b2d5dbbe6b593aceffa051efa",volumeInSeries:1,fullTitle:"Influenza - Therapeutics and Challenges",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}]},{type:"book",id:"7064",title:"Current Perspectives in Human Papillomavirus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7064.jpg",slug:"current-perspectives-in-human-papillomavirus",publishedDate:"May 2nd 2019",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}]},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"61c627da05b2ace83056d11357bdf361",volumeInSeries:3,fullTitle:"Current Topics in Neglected Tropical Diseases",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}]},{type:"book",id:"7839",title:"Malaria",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7839.jpg",slug:"malaria",publishedDate:"December 11th 2019",editedByType:"Edited by",bookSignature:"Fyson H. Kasenga",hash:"91cde4582ead884cb0f355a19b67cd56",volumeInSeries:4,fullTitle:"Malaria",editors:[{id:"86725",title:"Dr.",name:"Fyson",middleName:"Hanania",surname:"Kasenga",slug:"fyson-kasenga",fullName:"Fyson Kasenga",profilePictureURL:"https://mts.intechopen.com/storage/users/86725/images/system/86725.jpg",biography:"Dr. Kasenga is a graduate of Tumaini University, Kilimanjaro Christian Medical College, Moshi, Tanzania and Umeå University, Sweden. He obtained a Master’s degree in Public Health and PhD in Public Health and Epidemiology. He has a background in Clinical Medicine and has taken courses at higher diploma levels in public health from University of Transkei, Republic of South Africa, and African Medical and Research Foundation (AMREF) in Nairobi, Kenya. Dr. Kasenga worked in different places in and outside Malawi, and has held various positions, such as Licensed Medical Officer, HIV/AIDS Programme Officer, HIV/AIDS resource person in the International Department of Diakonhjemet College, Oslo, Norway. He also managed an Integrated HIV/AIDS Prevention programme for over 5 years. He is currently working as a Director for the Health Ministries Department of Malawi Union of the Seventh Day Adventist Church. Dr. Kasenga has published over 5 articles on HIV/AIDS issues focusing on Prevention of Mother to Child Transmission of HIV (PMTCT), including a book chapter on HIV testing counseling (currently in press). Dr. Kasenga is married to Grace and blessed with three children, a son and two daughters: Happy, Lettice and Sungani.",institutionString:"Malawi Adventist University",institution:{name:"Malawi Adventist University",institutionURL:null,country:{name:"Malawi"}}}]}]},openForSubmissionBooks:{paginationCount:7,paginationItems:[{id:"11476",title:"Globalization and Sustainability - Recent Advances, New Perspectives and Emerging Issues",coverURL:"https://cdn.intechopen.com/books/images_new/11476.jpg",hash:"8d41fa5f3a5da07469bbc121594bfd3e",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"March 24th 2022",isOpenForSubmission:!0,editors:[{id:"335401",title:"Prof.",name:"Margherita",surname:"Mori",slug:"margherita-mori",fullName:"Margherita Mori"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11460",title:"Pluralistic Approaches for Conservation and Sustainability in Biodiversity",coverURL:"https://cdn.intechopen.com/books/images_new/11460.jpg",hash:"ab014f8ed1669757335225786833e9a9",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"April 22nd 2022",isOpenForSubmission:!0,editors:[{id:"101105",title:"Dr.",name:"Gopal",surname:"Shukla",slug:"gopal-shukla",fullName:"Gopal Shukla"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11475",title:"Food Security Challenges and Approaches",coverURL:"https://cdn.intechopen.com/books/images_new/11475.jpg",hash:"090302a30e461cee643ec49675c811ec",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 5th 2022",isOpenForSubmission:!0,editors:[{id:"292145",title:"Dr.",name:"Muhammad",surname:"Haseeb Ahmad",slug:"muhammad-haseeb-ahmad",fullName:"Muhammad Haseeb Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11450",title:"Environmental Impacts of COVID-19 Pandemic on the World",coverURL:"https://cdn.intechopen.com/books/images_new/11450.jpg",hash:"a58c7b02d07903004be70f744f2e1835",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 10th 2022",isOpenForSubmission:!0,editors:[{id:"63465",title:"Prof.",name:"Mohamed Nageeb",surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11477",title:"Public Economics - New Perspectives and Uncertainty",coverURL:"https://cdn.intechopen.com/books/images_new/11477.jpg",hash:"a8e6c515dc924146fbd2712eb4e7d118",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"May 27th 2022",isOpenForSubmission:!0,editors:[{id:"414400",title:"Dr.",name:"Habtamu",surname:"Alem",slug:"habtamu-alem",fullName:"Habtamu Alem"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11457",title:"Forest Degradation Under Global Change",coverURL:"https://cdn.intechopen.com/books/images_new/11457.jpg",hash:"8df7150b01ae754024c65d1a62f190d9",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"June 1st 2022",isOpenForSubmission:!0,editors:[{id:"317087",title:"Dr.",name:"Pavel",surname:"Samec",slug:"pavel-samec",fullName:"Pavel Samec"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11474",title:"Quality of Life Interventions - Magnitude of Effect and Transferability",coverURL:"https://cdn.intechopen.com/books/images_new/11474.jpg",hash:"5a6bcdaf5ee144d043bcdab893ff9e1c",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"June 2nd 2022",isOpenForSubmission:!0,editors:[{id:"245319",title:"Ph.D.",name:"Sage",surname:"Arbor",slug:"sage-arbor",fullName:"Sage Arbor"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:43,paginationItems:[{id:"81796",title:"Apoptosis-Related Diseases and Peroxisomes",doi:"10.5772/intechopen.105052",signatures:"Meimei Wang, Yakun Liu, Ni Chen, Juan Wang and Ye Zhao",slug:"apoptosis-related-diseases-and-peroxisomes",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81723",title:"Peroxisomal Modulation as Therapeutic Alternative for Tackling Multiple Cancers",doi:"10.5772/intechopen.104873",signatures:"Shazia Usmani, Shadma Wahab, Abdul Hafeez, Shabana Khatoon and Syed Misbahul Hasan",slug:"peroxisomal-modulation-as-therapeutic-alternative-for-tackling-multiple-cancers",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81638",title:"Aging and Neuropsychiatric Disease: A General Overview of Prevalence and Trends",doi:"10.5772/intechopen.103102",signatures:"Jelena Milić",slug:"aging-and-neuropsychiatric-disease-a-general-overview-of-prevalence-and-trends",totalDownloads:14,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81566",title:"New and Emerging Technologies for Integrative Ambulatory Autonomic Assessment and Intervention as a Catalyst in the Synergy of Remote Geocoded Biosensing, Algorithmic Networked Cloud Computing, Deep Learning, and Regenerative/Biomic Medicine: Further Real",doi:"10.5772/intechopen.104092",signatures:"Robert L. Drury",slug:"new-and-emerging-technologies-for-integrative-ambulatory-autonomic-assessment-and-intervention-as-a-",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"81576",title:"Carotenoids in Thermal Adaptation of Plants and Animals",doi:"10.5772/intechopen.104537",signatures:"Ivan M. Petyaev",slug:"carotenoids-in-thermal-adaptation-of-plants-and-animals",totalDownloads:16,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Ivan",surname:"Petyaev"}],book:{title:"Carotenoids - New Perspectives and Application",coverURL:"https://cdn.intechopen.com/books/images_new/10836.jpg",subseries:{id:"13",title:"Plant Physiology"}}},{id:"81358",title:"New Insights on Carotenoid Production by Gordonia alkanivorans Strain 1B",doi:"10.5772/intechopen.103919",signatures:"Tiago P. Silva, Susana M. Paixão, Ana S. Fernandes, José C. Roseiro and Luís Alves",slug:"new-insights-on-carotenoid-production-by-gordonia-alkanivorans-strain-1b",totalDownloads:13,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Carotenoids - New Perspectives and Application",coverURL:"https://cdn.intechopen.com/books/images_new/10836.jpg",subseries:{id:"13",title:"Plant Physiology"}}},{id:"81298",title:"Roles of Extracellular Vesicles in Cancer Metastasis",doi:"10.5772/intechopen.103798",signatures:"Eman Helmy Thabet",slug:"roles-of-extracellular-vesicles-in-cancer-metastasis",totalDownloads:20,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Extracellular Vesicles - Role in Diseases, Pathogenesis and Therapy",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81290",title:"Musculoskeletal Abnormalities Caused by Cystic Fibrosis",doi:"10.5772/intechopen.104591",signatures:"Mark Lambrechts",slug:"musculoskeletal-abnormalities-caused-by-cystic-fibrosis",totalDownloads:13,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Advances in Skeletal Muscle Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/11675.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81286",title:"Potassium Derangements: A Pathophysiological Review, Diagnostic Approach, and Clinical Management",doi:"10.5772/intechopen.103016",signatures:"Sairah Sharif and Jie Tang",slug:"potassium-derangements-a-pathophysiological-review-diagnostic-approach-and-clinical-management",totalDownloads:24,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"81246",title:"Role of Carotenoids in Cardiovascular Disease",doi:"10.5772/intechopen.102750",signatures:"Arslan Ahmad, Sakhawat Riaz, Muhammad Shahzaib Nadeem, Umber Mubeen and Khadija Maham",slug:"role-of-carotenoids-in-cardiovascular-disease",totalDownloads:27,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Carotenoids - New Perspectives and Application",coverURL:"https://cdn.intechopen.com/books/images_new/10836.jpg",subseries:{id:"13",title:"Plant Physiology"}}}]},subseriesFiltersForOFChapters:[{caption:"Plant Physiology",value:13,count:5,group:"subseries"},{caption:"Human Physiology",value:12,count:13,group:"subseries"},{caption:"Cell Physiology",value:11,count:25,group:"subseries"}],publishedBooks:{paginationCount:12,paginationItems:[{type:"book",id:"9883",title:"Biosensors",subtitle:"Current and Novel Strategies for Biosensing",coverURL:"https://cdn.intechopen.com/books/images_new/9883.jpg",slug:"biosensors-current-and-novel-strategies-for-biosensing",publishedDate:"May 5th 2021",editedByType:"Edited by",bookSignature:"Luis Jesús Villarreal-Gómez and Ana Leticia Iglesias",hash:"028f3e5dbf9c32590183ac4b4f0a2825",volumeInSeries:11,fullTitle:"Biosensors - Current and Novel Strategies for Biosensing",editors:[{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9959",title:"Biomedical Signal and Image Processing",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9959.jpg",slug:"biomedical-signal-and-image-processing",publishedDate:"April 14th 2021",editedByType:"Edited by",bookSignature:"Yongxia Zhou",hash:"22b87a09bd6df065d78c175235d367c8",volumeInSeries:10,fullTitle:"Biomedical Signal and Image Processing",editors:[{id:"259308",title:"Dr.",name:"Yongxia",middleName:null,surname:"Zhou",slug:"yongxia-zhou",fullName:"Yongxia Zhou",profilePictureURL:"https://mts.intechopen.com/storage/users/259308/images/system/259308.jpeg",institutionString:"University of Southern California",institution:{name:"University of Southern California",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9973",title:"Data Acquisition",subtitle:"Recent Advances and Applications in Biomedical Engineering",coverURL:"https://cdn.intechopen.com/books/images_new/9973.jpg",slug:"data-acquisition-recent-advances-and-applications-in-biomedical-engineering",publishedDate:"March 17th 2021",editedByType:"Edited by",bookSignature:"Bartłomiej Płaczek",hash:"75ea6cdd241216c9db28aa734ab34446",volumeInSeries:9,fullTitle:"Data Acquisition - Recent Advances and Applications in Biomedical Engineering",editors:[{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",institutionString:"University of Silesia",institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9905",title:"Biometric Systems",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9905.jpg",slug:"biometric-systems",publishedDate:"February 10th 2021",editedByType:"Edited by",bookSignature:"Muhammad Sarfraz",hash:"c730560dd2e3837a03407b3a86b0ef2a",volumeInSeries:8,fullTitle:"Biometric Systems",editors:[{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",institutionString:"Kuwait University",institution:{name:"Kuwait University",institutionURL:null,country:{name:"Kuwait"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8622",title:"Peptide Synthesis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8622.jpg",slug:"peptide-synthesis",publishedDate:"December 18th 2019",editedByType:"Edited by",bookSignature:"Jaya T. Varkey",hash:"de9fa48c5248dbfb581825b8c74f5623",volumeInSeries:0,fullTitle:"Peptide Synthesis",editors:[{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",institutionString:"St. Teresa’s College",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7497",title:"Computer Vision in Dentistry",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7497.jpg",slug:"computer-vision-in-dentistry",publishedDate:"September 18th 2019",editedByType:"Edited by",bookSignature:"Monika Elzbieta Machoy",hash:"1e9812cebd46ef9e28257f3e96547f6a",volumeInSeries:7,fullTitle:"Computer Vision in Dentistry",editors:[{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8633",title:"Novel Diagnostic Methods in Ophthalmology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8633.jpg",slug:"novel-diagnostic-methods-in-ophthalmology",publishedDate:"September 4th 2019",editedByType:"Edited by",bookSignature:"Anna Nowinska",hash:"da2c90e8db647ead30504defce3fb5d3",volumeInSeries:6,fullTitle:"Novel Diagnostic Methods in Ophthalmology",editors:[{id:"261466",title:"Dr.",name:"Anna",middleName:"Karolina",surname:"Nowińska",slug:"anna-nowinska",fullName:"Anna Nowińska",profilePictureURL:"https://mts.intechopen.com/storage/users/261466/images/system/261466.jpeg",institutionString:"Medical University of Silesia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7437",title:"Nanomedicines",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7437.jpg",slug:"nanomedicines",publishedDate:"February 13th 2019",editedByType:"Edited by",bookSignature:"Muhammad Akhyar Farrukh",hash:"0e1f5f6258f074c533976c4f4d248568",volumeInSeries:5,fullTitle:"Nanomedicines",editors:[{id:"63182",title:"Dr.",name:"Muhammad Akhyar",middleName:null,surname:"Farrukh",slug:"muhammad-akhyar-farrukh",fullName:"Muhammad Akhyar Farrukh",profilePictureURL:"https://mts.intechopen.com/storage/users/63182/images/system/63182.png",institutionString:"Forman Christian College",institution:{name:"Forman Christian College",institutionURL:null,country:{name:"Pakistan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6843",title:"Biomechanics",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6843.jpg",slug:"biomechanics",publishedDate:"January 30th 2019",editedByType:"Edited by",bookSignature:"Hadi Mohammadi",hash:"85132976010be1d7f3dbd88662b785e5",volumeInSeries:4,fullTitle:"Biomechanics",editors:[{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",institutionURL:null,country:{name:"Canada"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7560",title:"Non-Invasive Diagnostic Methods",subtitle:"Image Processing",coverURL:"https://cdn.intechopen.com/books/images_new/7560.jpg",slug:"non-invasive-diagnostic-methods-image-processing",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Mariusz Marzec and Robert Koprowski",hash:"d92fd8cf5a90a47f2b8a310837a5600e",volumeInSeries:3,fullTitle:"Non-Invasive Diagnostic Methods - Image Processing",editors:[{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",institutionString:"University of Silesia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7218",title:"OCT",subtitle:"Applications in Ophthalmology",coverURL:"https://cdn.intechopen.com/books/images_new/7218.jpg",slug:"oct-applications-in-ophthalmology",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Michele Lanza",hash:"e3a3430cdfd6999caccac933e4613885",volumeInSeries:2,fullTitle:"OCT - Applications in Ophthalmology",editors:[{id:"240088",title:"Prof.",name:"Michele",middleName:null,surname:"Lanza",slug:"michele-lanza",fullName:"Michele Lanza",profilePictureURL:"https://mts.intechopen.com/storage/users/240088/images/system/240088.png",institutionString:'University of Campania "Luigi Vanvitelli"',institution:{name:'University of Campania "Luigi Vanvitelli"',institutionURL:null,country:{name:"Italy"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6692",title:"Medical and Biological Image Analysis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6692.jpg",slug:"medical-and-biological-image-analysis",publishedDate:"July 4th 2018",editedByType:"Edited by",bookSignature:"Robert Koprowski",hash:"e75f234a0fc1988d9816a94e4c724deb",volumeInSeries:1,fullTitle:"Medical and Biological Image Analysis",editors:[{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",slug:"robert-koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",value:9,count:1},{group:"subseries",caption:"Bioinspired Technology and Biomechanics",value:8,count:2},{group:"subseries",caption:"Bioinformatics and Medical Informatics",value:7,count:9}],publicationYearFilters:[{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2019",value:2019,count:5},{group:"publicationYear",caption:"2018",value:2018,count:3}],authors:{paginationCount:302,paginationItems:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/198499/images/system/198499.jpeg",biography:"Dr. Daniel Glossman-Mitnik is currently a Titular Researcher at the Centro de Investigación en Materiales Avanzados (CIMAV), Chihuahua, Mexico, as well as a National Researcher of Level III at the Consejo Nacional de Ciencia y Tecnología, Mexico. His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 255 peer-reviewed papers, 32 book chapters, and 2 edited books. He has delivered speeches at many international and domestic conferences. He serves as a reviewer for more than eighty international journals, books, and research proposals as well as an editor for special issues of renowned scientific journals.",institutionString:"Centro de Investigación en Materiales Avanzados",institution:{name:"Centro de Investigación en Materiales Avanzados",country:{name:"Mexico"}}},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. degree in chemistry in 2000 and Ph.D. degree in physical chemistry in 2007 from the University of Khartoum, Sudan. He moved to School of Chemistry, Faculty of Science, University of Sydney, Australia in 2009 and joined Dr. Ron Clarke as a postdoctoral fellow where he worked on the interaction of ATP with the phosphoenzyme of the Na+/K+-ATPase and dual mechanisms of allosteric acceleration of the Na+/K+-ATPase by ATP; then he went back to Department of Chemistry, University of Khartoum as an assistant professor, and in 2014 he was promoted as an associate professor. In 2011, he joined the staff of Department of Chemistry at Taif University, Saudi Arabia, where he is currently an assistant professor. His research interests include the following: P-Type ATPase enzyme kinetics and mechanisms, kinetics and mechanisms of redox reactions, autocatalytic reactions, computational enzyme kinetics, allosteric acceleration of P-type ATPases by ATP, exploring of allosteric sites of ATPases, and interaction of ATP with ATPases located in cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. Pakistan Institute of Nuclear Science & Technology (PINSTECH) Islamabad, Punjab Institute of Nuclear Medicine (PINM), Faisalabad and Institute of Nuclear Medicine and Radiology (INOR) Abbottabad are the main collaborating institutes.",institutionString:"Government College University",institution:{name:"Government College University, Faisalabad",country:{name:"Pakistan"}}},{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",country:{name:"Hungary"}}},{id:"277367",title:"M.Sc.",name:"Daniel",middleName:"Martin",surname:"Márquez López",slug:"daniel-marquez-lopez",fullName:"Daniel Márquez López",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/277367/images/7909_n.jpg",biography:"Msc Daniel Martin Márquez López has a bachelor degree in Industrial Chemical Engineering, a Master of science degree in the same área and he is a PhD candidate for the Instituto Politécnico Nacional. His Works are realted to the Green chemistry field, biolubricants, biodiesel, transesterification reactions for biodiesel production and the manipulation of oils for therapeutic purposes.",institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",country:{name:"Argentina"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",biography:"Francisco Javier Martín-Romero (Javier) is a Professor of Biochemistry and Molecular Biology at the University of Extremadura, Spain. He is also a group leader at the Biomarkers Institute of Molecular Pathology. Javier received his Ph.D. in 1998 in Biochemistry and Biophysics. At the National Cancer Institute (National Institute of Health, Bethesda, MD) he worked as a research associate on the molecular biology of selenium and its role in health and disease. After postdoctoral collaborations with Carlos Gutierrez-Merino (University of Extremadura, Spain) and Dario Alessi (University of Dundee, UK), he established his own laboratory in 2008. The interest of Javier's lab is the study of cell signaling with a special focus on Ca2+ signaling, and how Ca2+ transport modulates the cytoskeleton, migration, differentiation, cell death, etc. He is especially interested in the study of Ca2+ channels, and the role of STIM1 in the initiation of pathological events.",institutionString:null,institution:{name:"University of Extremadura",country:{name:"Spain"}}},{id:"217323",title:"Prof.",name:"Guang-Jer",middleName:null,surname:"Wu",slug:"guang-jer-wu",fullName:"Guang-Jer Wu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217323/images/8027_n.jpg",biography:null,institutionString:null,institution:null},{id:"148546",title:"Dr.",name:"Norma Francenia",middleName:null,surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/148546/images/4640_n.jpg",biography:null,institutionString:null,institution:null},{id:"272889",title:"Dr.",name:"Narendra",middleName:null,surname:"Maddu",slug:"narendra-maddu",fullName:"Narendra Maddu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272889/images/10758_n.jpg",biography:null,institutionString:null,institution:null},{id:"242491",title:"Prof.",name:"Angelica",middleName:null,surname:"Rueda",slug:"angelica-rueda",fullName:"Angelica Rueda",position:"Investigador Cinvestav 3B",profilePictureURL:"https://mts.intechopen.com/storage/users/242491/images/6765_n.jpg",biography:null,institutionString:null,institution:null},{id:"88631",title:"Dr.",name:"Ivan",middleName:null,surname:"Petyaev",slug:"ivan-petyaev",fullName:"Ivan Petyaev",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Lycotec (United Kingdom)",country:{name:"United Kingdom"}}},{id:"423869",title:"Ms.",name:"Smita",middleName:null,surname:"Rai",slug:"smita-rai",fullName:"Smita Rai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424024",title:"Prof.",name:"Swati",middleName:null,surname:"Sharma",slug:"swati-sharma",fullName:"Swati Sharma",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"439112",title:"MSc.",name:"Touseef",middleName:null,surname:"Fatima",slug:"touseef-fatima",fullName:"Touseef Fatima",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424836",title:"Dr.",name:"Orsolya",middleName:null,surname:"Borsai",slug:"orsolya-borsai",fullName:"Orsolya Borsai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca",country:{name:"Romania"}}},{id:"422262",title:"Ph.D.",name:"Paola Andrea",middleName:null,surname:"Palmeros-Suárez",slug:"paola-andrea-palmeros-suarez",fullName:"Paola Andrea Palmeros-Suárez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Guadalajara",country:{name:"Mexico"}}}]}},subseries:{item:{id:"12",type:"subseries",title:"Human Physiology",keywords:"Anatomy, Cells, Organs, Systems, Homeostasis, Functions",scope:"Human physiology is the scientific exploration of the various functions (physical, biochemical, and mechanical properties) of humans, their organs, and their constituent cells. The endocrine and nervous systems play important roles in maintaining homeostasis in the human body. Integration, which is the biological basis of physiology, is achieved through communication between the many overlapping functions of the human body's systems, which takes place through electrical and chemical means. Much of the basis of our knowledge of human physiology has been provided by animal experiments. Because of the close relationship between structure and function, studies in human physiology and anatomy seek to understand the mechanisms that help the human body function. The series on human physiology deals with the various mechanisms of interaction between the various organs, nerves, and cells in the human body.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11408,editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded his sports science diploma in 1995 by the University of Tsukuba and began his scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:null,editorThree:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. Her main research interest is sarcopenia in older adults, especially its association with nutritional status. Additionally, to understand how to maintain and improve physical function in older adults, to conduct studies about the mechanism of sarcopenia and determine when possible interventions are needed.",institutionString:null,institution:{name:"Ritsumeikan University",institutionURL:null,country:{name:"Japan"}}},series:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261"},editorialBoard:[{id:"213786",title:"Dr.",name:"Henrique P.",middleName:null,surname:"Neiva",slug:"henrique-p.-neiva",fullName:"Henrique P. Neiva",profilePictureURL:"https://mts.intechopen.com/storage/users/213786/images/system/213786.png",institutionString:null,institution:{name:"University of Beira Interior",institutionURL:null,country:{name:"Portugal"}}},{id:"39275",title:"Prof.",name:"Herbert Ryan",middleName:null,surname:"Marini",slug:"herbert-ryan-marini",fullName:"Herbert Ryan Marini",profilePictureURL:"https://mts.intechopen.com/storage/users/39275/images/9459_n.jpg",institutionString:null,institution:{name:"University of Messina",institutionURL:null,country:{name:"Italy"}}},{id:"196218",title:"Dr.",name:"Pasquale",middleName:null,surname:"Cianci",slug:"pasquale-cianci",fullName:"Pasquale Cianci",profilePictureURL:"https://mts.intechopen.com/storage/users/196218/images/system/196218.png",institutionString:null,institution:{name:"University of Foggia",institutionURL:null,country:{name:"Italy"}}}]},onlineFirstChapters:{paginationCount:13,paginationItems:[{id:"81566",title:"New and Emerging Technologies for Integrative Ambulatory Autonomic Assessment and Intervention as a Catalyst in the Synergy of Remote Geocoded Biosensing, Algorithmic Networked Cloud Computing, Deep Learning, and Regenerative/Biomic Medicine: Further Real",doi:"10.5772/intechopen.104092",signatures:"Robert L. Drury",slug:"new-and-emerging-technologies-for-integrative-ambulatory-autonomic-assessment-and-intervention-as-a-",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"81286",title:"Potassium Derangements: A Pathophysiological Review, Diagnostic Approach, and Clinical Management",doi:"10.5772/intechopen.103016",signatures:"Sairah Sharif and Jie Tang",slug:"potassium-derangements-a-pathophysiological-review-diagnostic-approach-and-clinical-management",totalDownloads:24,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80895",title:"Heart Rate Variability as a Marker of Homeostatic Level",doi:"10.5772/intechopen.102500",signatures:"Moacir Fernandes de Godoy and Michele Lima Gregório",slug:"heart-rate-variability-as-a-marker-of-homeostatic-level",totalDownloads:25,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Moacir",surname:"Godoy"},{name:"Michele",surname:"Gregório"}],book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80433",title:"Heart Autonomic Nervous System: Basic Science and Clinical Implications",doi:"10.5772/intechopen.101718",signatures:"Elvan Wiyarta and Nayla Karima",slug:"heart-autonomic-nervous-system-basic-science-and-clinical-implications",totalDownloads:50,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80316",title:"Central Control of the Larynx in Mammals",doi:"10.5772/intechopen.102009",signatures:"Manuel Víctor López-González, Marta González-García, Laura Carrillo-Franco, Amelia Díaz-Casares and Marc Stefan Dawid-Milner",slug:"central-control-of-the-larynx-in-mammals",totalDownloads:36,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80402",title:"General Anesthesia and Autonomic Nervous System: Control and Management in Neurosurgery",doi:"10.5772/intechopen.101829",signatures:"Irina Alexandrovna Savvina, Anna Olegovna Petrova and Yulia Mikhailovna Zabrodskaya",slug:"general-anesthesia-and-autonomic-nervous-system-control-and-management-in-neurosurgery",totalDownloads:58,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80035",title:"Healthy Lifestyle, Autonomic Nervous System Activity, and Sleep Status for Healthy Aging",doi:"10.5772/intechopen.101837",signatures:"Miki Sato, Feni Betriana, Ryuichi Tanioka, Kyoko Osaka, Tetsuya Tanioka and Savina Schoenhofer",slug:"healthy-lifestyle-autonomic-nervous-system-activity-and-sleep-status-for-healthy-aging",totalDownloads:60,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80175",title:"Signaling Pathways Regulating Axogenesis and Dendritogenesis in Sympathetic Neurons",doi:"10.5772/intechopen.102442",signatures:"Vidya Chandrasekaran",slug:"signaling-pathways-regulating-axogenesis-and-dendritogenesis-in-sympathetic-neurons",totalDownloads:68,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Vidya",surname:"Chandrasekaran"}],book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80176",title:"Impacts of Environmental Stressors on Autonomic Nervous System",doi:"10.5772/intechopen.101842",signatures:"Mayowa Adeniyi",slug:"impacts-of-environmental-stressors-on-autonomic-nervous-system",totalDownloads:66,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"79655",title:"The Autonomic Nervous System, Sex Differences, and Chronobiology under General Anesthesia in In Vivo Experiments Involving Rats",doi:"10.5772/intechopen.101075",signatures:"Pavol Svorc Jr and Pavol Svorc",slug:"the-autonomic-nervous-system-sex-differences-and-chronobiology-under-general-anesthesia-in-in-vivo-e",totalDownloads:91,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"79194",title:"Potassium in Solid Cancers",doi:"10.5772/intechopen.101108",signatures:"Jessica Iorio, Lisa Lastraioli and Elena Lastraioli",slug:"potassium-in-solid-cancers",totalDownloads:119,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"78820",title:"Potassium Homeostasis",doi:"10.5772/intechopen.100368",signatures:"Shakuntala S. Patil and Sachin M. Patil",slug:"potassium-homeostasis",totalDownloads:108,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"78193",title:"Potassium and Cardiac Surgery",doi:"10.5772/intechopen.99735",signatures:"Shawn Kant, Frank W. Sellke and Jun Feng",slug:"potassium-and-cardiac-surgery",totalDownloads:176,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg",subseries:{id:"12",title:"Human Physiology"}}}]},publishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"10795",title:"Plant Stress Physiology",subtitle:"Perspectives in Agriculture",coverURL:"https://cdn.intechopen.com/books/images_new/10795.jpg",slug:"plant-stress-physiology-perspectives-in-agriculture",publishedDate:"April 28th 2022",editedByType:"Edited by",bookSignature:"Mirza Hasanuzzaman and Kamran Nahar",hash:"c5a7932b74fe612b256bf95d0709756e",volumeInSeries:11,fullTitle:"Plant Stress Physiology - Perspectives in Agriculture",editors:[{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",institutionURL:null,country:{name:"Bangladesh"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/40533",hash:"",query:{},params:{id:"40533"},fullPath:"/chapters/40533",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()