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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"7447",leadTitle:null,fullTitle:"Vignettes in Patient Safety - Volume 4",title:"Vignettes in Patient Safety",subtitle:"Volume 4",reviewType:"peer-reviewed",abstract:"Medical errors contribute significantly to morbidity and mortality across our healthcare institutions. Due to the increasing complexity of the modern medical practice, a perfect storm of regulatory, market, social, and technical factors, and other competing priorities, created an environment that is primed for patient safety lapses. The spectrum of contributing variables - ranging from minor errors that subsequently escalate, poor communication, and protocol/process non-compliance (just to name a few) - is extensive and solutions are only recently being described. As such, there is a growing body of research and experiences that can help provide an organized framework - based on best practices and evidence-based medical principles - for healthcare organizations to develop, implement, and embrace. Based on the tremendous interest in the initial three volumes of our Vignettes in Patient Safety series, this fourth volume follows a similar model of outlining a patient safety case based on experiences that many clinicians can relate to, and then discusses various factors that may have contributed to a medical error, complication, and/or poor outcome. Building on a problem-based clinical vignette, each chapter then outlines an evidence-based approach to present any related literature, pertinent evidence, and potential contributing factors and solutions to common patient safety occurrences. By focusing on some of the best practices, structured experiences, and objective approaches to medical error genesis, the authors and editors hopefully can lend some insights into how we can make healthcare encounters for all patients, across all settings, better and safer.",isbn:"978-1-83962-202-1",printIsbn:"978-1-83962-201-4",pdfIsbn:"978-1-83962-203-8",doi:"10.5772/intechopen.75373",price:119,priceEur:129,priceUsd:155,slug:"vignettes-in-patient-safety-volume-4",numberOfPages:164,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"88d9ec0c55c5e7e973a35eafa413ded2",bookSignature:"Stanislaw P. Stawicki and Michael S. Firstenberg",publishedDate:"September 18th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/7447.jpg",numberOfDownloads:10202,numberOfWosCitations:1,numberOfCrossrefCitations:7,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:21,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:29,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 19th 2018",dateEndSecondStepPublish:"May 21st 2018",dateEndThirdStepPublish:"July 20th 2018",dateEndFourthStepPublish:"October 8th 2018",dateEndFifthStepPublish:"December 7th 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"181694",title:"Dr.",name:"Stanislaw P.",middleName:null,surname:"Stawicki",slug:"stanislaw-p.-stawicki",fullName:"Stanislaw P. Stawicki",profilePictureURL:"https://mts.intechopen.com/storage/users/181694/images/system/181694.jpeg",biography:"Dr. Stanislaw P. Stawicki is a Professor of Surgery and chair of the Department of Research and Innovation, St. Luke\\'s University Health Network, Bethlehem, Pennsylvania. A specialist in general surgery, surgical critical care, and neurocritical care, he has co-authored more than 650 scholarly works, including more than 20 books. In addition to local, national, and international medical leadership roles, Dr. Stawicki is a member of numerous editorial boards. His areas of expertise are diverse and include health security, medical information security, blockchain technology, patient safety, academic leadership, mentorship and leadership development, traumatology, surgical critical care, and sonography.",institutionString:"St. Luke's University Health Network",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"33",totalChapterViews:"0",totalEditedBooks:"8",institution:{name:"St. Luke's University Health Network",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"64343",title:"Dr.",name:"Michael S.",middleName:null,surname:"Firstenberg",slug:"michael-s.-firstenberg",fullName:"Michael S. Firstenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/64343/images/system/64343.png",biography:"Dr. Michael S. Firstenberg is a thoracic surgeon at the St. Elizabeth Medical Center (Ascension), Appleton, Wisconsin. He attended Case Western Reserve University Medical School, Cleveland, OH, received his general surgery training at University Hospitals in Cleveland, and completed thoracic surgery fellowships at The Ohio State University and the Cleveland Clinic. He is an active member of the Society of Thoracic Surgeons (STS), American Association of Thoracic Surgeons (AATS), American College of Cardiology (ACC), and American College of Academic International Medicine (ACAIM), for which he served as president in 2021–2022. He has authored more than 250 peer-reviewed manuscripts, abstracts, and book chapters and has edited several textbooks and lectured worldwide on topics ranging from medical leadership, COVID-19, endocarditis, and extra-corporeal membrane oxygenation (ECMO).",institutionString:"St. Elizabeth Medical Center",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"26",totalChapterViews:"0",totalEditedBooks:"13",institution:{name:"The Medical Center of Aurora",institutionURL:null,country:{name:"United States of America"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1132",title:"Health Care",slug:"medicine-public-health-health-care"}],chapters:[{id:"65624",title:"Introductory Chapter: Patient Safety is the Cornerstone of Modern Health-Care Delivery Systems",doi:"10.5772/intechopen.83842",slug:"introductory-chapter-patient-safety-is-the-cornerstone-of-modern-health-care-delivery-systems",totalDownloads:922,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Stanislaw P. Stawicki, Alyssa M. Green, Gary G. Lu, Gregory Domer, Timothy Oskin and Michael S. Firstenberg",downloadPdfUrl:"/chapter/pdf-download/65624",previewPdfUrl:"/chapter/pdf-preview/65624",authors:[{id:"181694",title:"Dr.",name:"Stanislaw P.",surname:"Stawicki",slug:"stanislaw-p.-stawicki",fullName:"Stanislaw P. Stawicki"}],corrections:null},{id:"62934",title:"Patient Safety Culture in Portuguese Primary Care: Validation of the Portuguese Version of the Medical Office Survey",doi:"10.5772/intechopen.80035",slug:"patient-safety-culture-in-portuguese-primary-care-validation-of-the-portuguese-version-of-the-medica",totalDownloads:1042,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Background: Assessing patient safety culture is a strategic priority worldwide, and Portugal is no exception.",signatures:"Margarida Eiras, Ana Escoval and Carina Silva",downloadPdfUrl:"/chapter/pdf-download/62934",previewPdfUrl:"/chapter/pdf-preview/62934",authors:[{id:"251030",title:"Prof.",name:"Margarida",surname:"Eiras",slug:"margarida-eiras",fullName:"Margarida Eiras"},{id:"251724",title:"Prof.",name:"Carina",surname:"Silva",slug:"carina-silva",fullName:"Carina Silva"},{id:"264735",title:"Prof.",name:"Ana",surname:"Escoval",slug:"ana-escoval",fullName:"Ana Escoval"}],corrections:null},{id:"65739",title:"Communication in Surgery for Patient Safety",doi:"10.5772/intechopen.79740",slug:"communication-in-surgery-for-patient-safety",totalDownloads:1042,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"One of the cardinal pieces of the Hippocratic Oath is “do no harm”; yet, even in the very best of contexts, errors, at times fatal, do occur as was reported by the Institute of Medicine. Surgical procedures are known to cause the majority of serious adverse events. The Joint Commission report indicates that 60% of serious adverse events are caused by the lack of physician-patient communication. Some of the factors that make surgical processes prone to medical errors include the number of steps and people involved and the fact that the interventions intended for the healing are often in themselves invasive and can also complicate. The involvement of more than one discipline and individual requires communication that is clear, understandable, culturally sensitive, and contextually relevant. One of the center pieces of quality care is its patient-centeredness. This refers to providing service that is not only respectful but also responsive to individual patients involving them in the decisions, ensuring their values and preferences are taken into consideration. It also demands that the care giver provides the patients with relevant and understandable information to enable them in the decision-making and make informed choices.",signatures:"Daniel Kinyuru Ojuka, Lydia Okutoyi and Frederick C. Otieno",downloadPdfUrl:"/chapter/pdf-download/65739",previewPdfUrl:"/chapter/pdf-preview/65739",authors:[{id:"251768",title:"Ph.D.",name:"Daniel",surname:"Ojuka",slug:"daniel-ojuka",fullName:"Daniel Ojuka"},{id:"263376",title:"Dr.",name:"Lydia",surname:"Okutoyi",slug:"lydia-okutoyi",fullName:"Lydia Okutoyi"},{id:"263377",title:"Prof.",name:"Frederick",surname:"Otieno",slug:"frederick-otieno",fullName:"Frederick Otieno"}],corrections:null},{id:"66677",title:"Fundamentals of Medical Radiation Safety: Focus on Reducing Short-Term and Long-Term Harmful Exposures",doi:"10.5772/intechopen.85689",slug:"fundamentals-of-medical-radiation-safety-focus-on-reducing-short-term-and-long-term-harmful-exposure",totalDownloads:1216,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"This chapter provides an overview of key topics in the area of radiation safety. Three clinical vignettes will serve to frame the review of the literature around both diagnostic radiation exposure and the risk of radioisotope contamination. Advancement in medical technology is rarely innocuous, and the use of radiation as both means to diagnose and treat certain conditions is not an exception. It is very important for clinicians to review the basics of harmful medical radiation exposure since, although seldom encountered, treatment, and outcomes are time sensitive. The advent of newer technology and the widespread availability of equipment will only serve to increase the prevalence of potentially harmful medical radiation exposure. Moreover, this chapter aims to explore current multidisciplinary endeavors to provide safe and efficient use of radiation in medicine. Solely relying on the medical profession for development of safeguards against harmful medical radiation exposure would be an impossible task. This is why it is crucial for professionals such as health physicists, radiation safety enforcement officers, and policy-makers at the state, national, and international level to establish consensus guidelines aimed toward safe, reliable utilization of radiation in medicine. Part of this interdisciplinary approach needs to focus on accurate education of patients. A thorough assessment of acute radiation syndrome, including diagnosis, treatment, and prognostic indicators is also part of this chapter. Furthermore, principles of screening for, and protection from, radiation contamination are outlined. Finally, areas for further research are identified throughout the chapter. The discussion takes into account both US-based and International research and practice guidelines.",signatures:"Alex Alers, Philip Salen, Vikas Yellapu, Manish Garg, Charles Bendas, Nicholas Cardiges, Gregory Domer, Timothy Oskin, Jay Fisher and Stanislaw P. Stawicki",downloadPdfUrl:"/chapter/pdf-download/66677",previewPdfUrl:"/chapter/pdf-preview/66677",authors:[{id:"181694",title:"Dr.",name:"Stanislaw P.",surname:"Stawicki",slug:"stanislaw-p.-stawicki",fullName:"Stanislaw P. Stawicki"}],corrections:null},{id:"62826",title:"The Anatomy of Medication Errors",doi:"10.5772/intechopen.79778",slug:"the-anatomy-of-medication-errors",totalDownloads:1321,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:1,abstract:"Medication errors constitute a category of errors that occur more frequently in healthcare units. They refer to every preventable event that may cause or lead to the inappropriate use of medicines or patient injury, during the therapeutic process. This type of events may be associated with professional practices, healthcare products, procedures, and systems including prescription, communication through instructions, drug labeling, packaging and nomenclature, reformulation, dissolution, distribution, administration, education, monitoring, and use. Classification and evaluation of medication errors according to their importance may constitute an important factor for process improvement in order to render the administration of medicines as safe as possible. The main categories of causes that lead to medication errors are those associated with the healthcare provider system, the healthcare professional, the pharmacy, and the scientific competence of the personnel. Technology has grown to be a constituent part of medicine these days. The appropriate technology is able to assist in increased efficiency, enhanced quality, and lessened costs. A few advantages that technology can supply are categorized as follows: the assisting of communication between clinicians; enhancing medication safety; decreasing potential medical errors and adverse events; rising access to medical information and encouraging patient-centered healthcare. The aim of this chapter is to provide a compendious literature review regarding the definition, the classification, the causes, and the main strategies for preventing medication errors.",signatures:"Vasiliki Kapaki",downloadPdfUrl:"/chapter/pdf-download/62826",previewPdfUrl:"/chapter/pdf-preview/62826",authors:[{id:"201568",title:"Dr.",name:"Vasiliki",surname:"Kapaki",slug:"vasiliki-kapaki",fullName:"Vasiliki Kapaki"}],corrections:null},{id:"66118",title:"Combating Alarm Fatigue: The Quest for More Accurate and Safer Clinical Monitoring Equipment",doi:"10.5772/intechopen.84783",slug:"combating-alarm-fatigue-the-quest-for-more-accurate-and-safer-clinical-monitoring-equipment",totalDownloads:1446,totalCrossrefCites:0,totalDimensionsCites:5,hasAltmetrics:0,abstract:"As the demand for health-care services continues to increase, clinically efficient and cost-effective patient monitoring takes on a critically important role. Key considerations inherent to this area of concern include patient safety, reliability, ease of use, and cost containment. Unfortunately, even the most modern patient monitoring systems carry significant drawbacks that limit their effectiveness and/or applicability. Major opportunities for improvement in both equipment design and monitor utilization have been identified, including the presence of excessive false and nuisance alarms. When poorly optimized, clinical alarm activity can affect patient safety and may have a negative impact on care providers, leading to inappropriate alarm response time due to the so-called alarm fatigue (AF). Ultimately, consequences of AF include missed alerts of clinical significance, with substantial risk for patient harm and potentially fatal outcomes. Targeted quality improvement initiatives and staff training, as well as the proactive incorporation of technological improvements, are the best approaches to address key barriers to the optimal utilization of clinical alarms, AF reduction, better patient care, and improved provider job satisfaction.",signatures:"James Nguyen, Kendra Davis, Giuseppe Guglielmello and Stanislaw P. Stawicki",downloadPdfUrl:"/chapter/pdf-download/66118",previewPdfUrl:"/chapter/pdf-preview/66118",authors:[{id:"181694",title:"Dr.",name:"Stanislaw P.",surname:"Stawicki",slug:"stanislaw-p.-stawicki",fullName:"Stanislaw P. Stawicki"}],corrections:null},{id:"65572",title:"Dangers of Peripheral Intravenous Catheterization: The Forgotten Tourniquet and Other Patient Safety Considerations",doi:"10.5772/intechopen.83854",slug:"dangers-of-peripheral-intravenous-catheterization-the-forgotten-tourniquet-and-other-patient-safety-",totalDownloads:2323,totalCrossrefCites:3,totalDimensionsCites:7,hasAltmetrics:1,abstract:"Intravenous catheterization is a widely used invasive procedure, with applications in both ambulatory and hospital settings. Due to its inherently invasive nature, intravenous (IV) therapy is associated with a number of potential complications, many of which are directly relevant to patient safety (PS). PIV-related morbidity may be due to mechanical or nonmechanical factors. The most frequent nonmechanical peripheral venous catheterization adverse events (PVCAEs) include insertion site pain, phlebitis, hematoma formation, and infusate extravasation. The most common mechanical PVCAE is catheter obstruction/occlusion and dislodgement. Significant complications can also occur with the administration of incorrect type or wrong amount of IV fluids. Moreover, simultaneous infusion of incompatible medications can result in infusate precipitation. Finally, less frequent but significant complications have been reported, including bloodstream and local infections, air embolization, nerve damage, arterial puncture, skin necrosis associated with vasopressor infusions, and limb-threatening forgotten tourniquet events. Taken together, the above complications can lead to substantial patient discomfort, unnecessary or prolonged hospitalization, increased costs, and additional downstream morbidity. Efforts to prevent PVCAEs and improve patient outcomes should involve thorough provider education, clinical vigilance by all involved healthcare providers, health service level strategies, as well as the proactive participation of all stakeholders, including patients and their families.",signatures:"Parampreet Kaur, Claire Rickard, Gregory S. Domer and Kevin R. Glover",downloadPdfUrl:"/chapter/pdf-download/65572",previewPdfUrl:"/chapter/pdf-preview/65572",authors:[{id:"265790",title:"Dr.",name:"Parampreet",surname:"Kaur",slug:"parampreet-kaur",fullName:"Parampreet Kaur"}],corrections:null},{id:"65915",title:"Comprehensive and Live Air Purification as a Key Environmental, Clinical, and Patient Safety Factor: A Prospective Evaluation",doi:"10.5772/intechopen.84530",slug:"comprehensive-and-live-air-purification-as-a-key-environmental-clinical-and-patient-safety-factor-a-",totalDownloads:890,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:1,abstract:"Healthcare organizations strive to provide optimal patient experience by improving care quality and enhancing clinical outcomes, while containing associated costs. In the United States, the Center for Disease Control (CDC) estimates that more than 1.7 million people suffer from an infectious complication annually, representing between 5 and 10% of all hospital admissions and costs ranging between $35B and $88B. Most infectious surface fomites originate from air. Consequently, reducing airborne pathogens should be associated with reduced surface fomites. This study represents the first comprehensive evaluation of infectious and aerosolized pathogens and their speciation, location and concentration within a typical hospital setting. The study provides data regarding the relationship between airborne pathogens and air filtration methodologies in the context of the molecular and microbial epidemiology of illness and infections in the clinical setting. The results demonstrated that using a transformational air purification system provided comprehensive remediation of airborne pathogens and significantly reduced surface-oriented infectious fomites. Overall reduction of airborne and surface bacterial and fungal pathogens responsible for illness and infections will result in a reduction of associated illnesses and HAI rates and improved patient care metrics including stay duration and readmission rates. Improvements in these outcome metrics should correlate to risk mitigation and cost avoidance.",signatures:"Stanislaw P. Stawicki, Chad Brisendine, Lee Levicoff, Frank Ford, Beverly Snyder, Sherrine Eid and Kathryn C. 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The use of artificial intelligence in day to day life has increased since late 20th century as seen in many home appliances such as microwave oven, washing machine, camcorder etc which can figure out on their own what settings to use to perform their tasks optimally. Such intelligent machines make use of the soft computing techniques which treat human brain as their role model and mimic the ability of the human mind to effectively employ modes of reasoning that are approximate rather than exact. The conventional hard computing techniques require a precisely stated analytical model and often a lot of computational time. Premises and guiding principles of Hard Computing are precision, certainty, and rigor [1]. Many contemporary problems do not lend themselves to precise solutions such as recognition problems (handwriting, speech, objects and images), mobile robot coordination, forecasting, combinatorial problems etc. This is where soft computing techniques score over the conventional hard computing approach. Soft computing differs from conventional (hard) computing in that, unlike hard computing, it is tolerant of imprecision, uncertainty, partial truth, and approximation. The guiding principle of soft computing is to exploit the tolerance for imprecision, uncertainty, partial truth, and approximation to achieve tractability, robustness and low solution cost [1]. The principal constituents, i.e., tools, techniques of Soft Computing (SC) are Fuzzy Logic (FL), Neural Networks (NN), Evolutionary Computation (EC), Machine Learning (ML) and Probabilistic Reasoning (PR). Soft computing many times employs NN, EC, FL etc, in a complementary rather than a competitive way resulting into hybrid techniques like Adaptive Neuro-Fuzzy Interface System (ANFIS).
The application of soft computing techniques in the field of Civil Engineering started since early nineties and since encompassed almost all fields of Civil Engineering namely Structural Engineering, Construction Engineering and Management, Geotechnical Engineering, Environmental Engineering and lastly Hydraulic Engineering which is the focus of this chapter. The technique of ANN is now well established in the field of Civil Engineering to model various random and complex phenomena. Other techniques such as FL and EL caught attention of many research workers as a complimentary or alternative technique to ANN, particularly after knowing the drawbacks of ANN [2]. The soft computing tool of Genetic Programming which is essentially classified as an Evolutionary Computation (EC) technique has found its foot in the field of Hydraulic Engineering in general and modeling of water flows in particular since last 12 years or so. Modeling of water flows is perhaps the most daunting task ever faced by researchers in the field of Hydraulic Engineering owing to the randomness involved in many natural processes associated with the water flows. In pursuit of achieving more and more accuracy in estimation/forecasting of water related variables the researchers have made of use Genetic Programming for various tasks such as forecasting of runoff with or without rainfall, forecasting of ocean waves, currents, spatial mapping of waves to name a few. The present chapter takes a stalk of the applications of GP to model water flows which will enable the future researchers who want to pursue their research in this field. The chapter is organized as follows. Next section deals with basics of GP. A review of applications of GP in the field of Ocean Engineering is presented in the next section followed by review of applications in the field of hydrology. Few applications in the field of Hydraulics are discussed in the subsequent section. It may be noted that papers published in reputed international journals are only considered for review. Two case studies are presented next which are based on publications of the first author. The concluding remarks and future scope as envisaged by the authors are discussed at the end.
The paradigm of evolutionary processes distinguishes between an organism’s genotype, which is constructed of genetic material that is inherited from its parent or parents, and the organism’s phenotype, which is the coming to full physical presence of the organism in a certain given environment and is represented by a body and its associated collection of characteristics or phenotypic traits. Within this paradigm, there are three main criteria for an evolutionary process to occur as per [3] and they are
Criterion of Heredity: Offspring are similar to their parents: the genotype copying process maintains a high fidelity.
Criterion of Variability: Offspring are not exactly the same as their parents: the genotype copying process is not perfect.
Criterion of Fecundity: Variants leave different numbers of offspring: specific variations have an effect on behavior and behavior has an effect on reproductive success.
The evolutionary techniques can be differentiated into four main streams of Evolutionary Algorithm(EA) development [4] namely Evolution Strategies (ES), Evolutionary Programming (EP), Genetic Algorithms (GA) and Genetic Programming (GP) [5]. However, all evolutionary algorithms share the common property of applying evolutionary processes in the form of selection, mutation and reproduction on a population of individual structures that undergo evolution. The criterion of heredity is assured through the application of a crossover operator, whereas the criterion of variability is maintained through the application of a mutation operator. A selection mechanism then ‘favours’ the more fit entities so that they reproduce more often, providing the fecundity requirement necessary for an evolutionary process to proceed.
Like genetic algorithm (GA) the concept of Genetic Programming (GP) follows the principle of ‘survival of the fittest’ borrowed from the process of evolution occurring in nature. But unlike GA its solution is a computer program or an equation as against a set of numbers in the GA and hence it is convenient to use the same as a regression tool rather than an optimization one like the GA. GP operates on parse trees rather than on bit strings as in a GA, to approximate the equation (in symbolic form) or computer program that best describes how the output relates to the input variables. A good explanation of various concepts related to GP can be found in [5] Koza (1992). GP starts with a population of randomly generated computer programs on which computerized evolution process operates. Then a ‘tournament’ or competition is conducted by randomly selecting four programs from the population. GP measures how each program performs the user designated task. The two programs that perform the task best ‘win’ the tournament. GP algorithm then copies the two winner programs and transforms these copies into two new programs via crossover and mutation operators i.e. winners now have the ‘children.’ These two new child programs are then inserted into the population of programs, replacing the two loser programs from the tournament. Crossover is inspired by the exchange of genetic material occurring in sexual reproduction in biology. The creation of offspring’s continues (in an iterative manner) till a specified number of offspring’s in a generation are produced and further till another specified number of generations are created. The resulting offspring at the end of all this process (an equation or a computer program) is the solution of the problem. The GP thus transforms one population of individuals into another one in an iterative manner by following the natural genetic operations like reproduction, mutation and cross-over. Figure 1 shows general flowchart of GP as given by [5].
The tree based GP corresponds to the expressions (syntax trees) from a ‘functional programming language’ [5]. In this type, Functions are located at the inner nodes; while leaves of the tree hold input values and constants. A population of random trees representing the programs is initially constructed and genetic operations are performed on these trees to generate individuals with the help of two distinct sets; the terminal set T and the function set F.
Flowchart of Genetic programming (Ref: [
The second variant of GP is Linear genetic Programming (LGP) which uses a specific linear representation of computer programs. The name ‘linear’ refers to the structure of the (imperative) program representation only and does not stand for functional genetic programs that are restricted to a linear list of nodes only. On the contrary, it usually represents highly nonlinear solutions. Each individual (Program) in LGP is represented by a variable-length sequence of simple C language instructions, which operate on the registers or constants from predefined sets. The function setof the system can be composed of arithmetic operations (+, -, X, /), conditional branches, and function calls (f{x, xn, sqrt, ex,sin, cos, tan, log, ln }). Each function implicitly includes an assignment to a variable which facilitates use of multiple program outputs in LGP. LGP utilizes two-point string cross-over. A segment of random position and random length of an instruction is selected from each parents and exchanged. If one of the resulting children exceeds the maximum length, this cross-over is abandoned and restarted by exchanging equalized segments. An operand or operator of an instruction is changed by mutation into another symbol over the same set. The readers are referred to [7] and [8] for further details.
Gene-Expression Programming (GEP) is an extension of GP, developed by [5]. The genome is encoded as linear chromosomes of fixed length, as in Genetic Algorithm (GA); however, in GEP the genes are then expressed as a phenotype in the form of expression trees. GEP combines the advantages of both its predecessors, GA and GP, and removes their limitations. GEP is a full fledged genotype/phenotype system in which both are dealt with separately, whereas GP is a simple replicator system. As a consequence of this difference, the complete genotype/phenotype GEP system surpasses the older GP system by a factor of 100 to 60,000. In GEP, just like in other evolutionary methods, the process starts with the random generation of an initial population consisting of individual chromosomes of fixed length. The chromosomes may contain one or more than one genes. Each individual chromosome in the initial population is then expressed and its fitness is evaluated using one of the fitness function equations available in the literature. These chromosomes are then selected based on their fitness values using a roulette wheel selection process. Fitter chromosomes have greater chances of selection for passage to the next generation. After selection, these are reproduced with some modifications performed by the genetic operators. In Gene Expression Programming, genetic operators such as mutation, inversion, transposition and recombination are used for these modifications. Mutation is the most efficient genetic operator, and it is sometime used as the only means of modification. The new individuals are then subjected to the same process of modification, and the process continues until the maximum number of generations is reached or the required accuracy is achieved.
It is a known fact that many variables in the domain of Hydraulic Engineering are of random nature having a complex underlying phenomenon. For example the generation of ocean waves which are primarily functions of wind forcing is a very complex procedure. Forecasting of the ocean waves is an essential prerequisite for many ocean-coastal related activities. Traditionally this is done using numerical models like WAM and SWAN. These models are extremely complex in development and application besides being highly computation-intensive. Further they are more useful for forecasting over a large spatial and temporal domain. The accuracy levels of wave forecasts obtained through such numerical models again leaves scope for exploration of alternative schemes. These numerical models suffer from disadvantages like requirement of exogenous data, complex modeling procedure, rounding off errors and large requirement of computer memory and time and there is no guarantee that the results will be accurate. Particularly when point forecasts were required the researchers therefore used the data driven techniques namely ARMA, ARIMA and since last two decades or so the soft computing technique of Neural Networks. A comprehensive review of applications of ANN in Ocean Engineering is done by [9]. Although wave forecasting models were developed using Artificial Neural Networks by many research workers their was scope for use of another data driven techniques in that the ANN based models generally were unable to forecast extreme events with reasonable accuracy and the accuracy of forecasts decreases with increase in lead time as reported in many research papers. This became an ideal situation for the entry of another soft computing tool of GP which functions in a completely different way than ANN in that it does not involve any transfer function and evolves generations and generations of ‘offspring’ based on the ‘fitness criteria’ and genetic operations as explained in the earlier section the researchers thought, may be useful to capture the underlying trends better than ANN technique and can be used as a regressive tool. Same can be said about another important variable in hydraulic engineering “runoff or stream flow”.
The rainfall -runoff modeling is very complex procedure and many numerical schemes are available as well as a large number of attempts by ANNs are also been made [2, 10, 11]. Thus Genetic Programming entered in rainfall-runoff modeling. It was also found that GP results were superior to that of M5 Model Trees another data driven modeling technique [12, 13]. Apart from these two variables the use of GP for modeling for many hydraulic engineering processes was found necessary for similar reasons. A review of these applications particularly in Ocean Engineering, Hydrology and Hydraulics (all grouped under Hydraulic Engineering) will be presented in the next three sections.
As mentioned earlier papers published in reputed international journals are considered in this chapter. Primarily the applications of GP in Ocean Engineering were found for modeling of oceanic parameters like waves, water levels, zero cross wave periods, currents, wind, sediment transport and circular pile scour. Table 1 shows applications of GP in the field of Ocean Engineering listed chronologically followed by their review. This will facilitate the reader to have a glance of the work which would be presented next.
REF. NO. | YEAR | AUTHOR | TITLE OF PAPER | JOURNAL/PUBLICATION |
14 | 2007 | Kalra R., Deo M.C. | Genetic Programming to retrieve missing informationin wave records along the west coast of India | Applied Ocean Research |
25 | 2007 | Singh, A. K., Deo M.C., Sanil Kumar V. | Combined Neural network – genetic programming for sediment transport | Journal of Maritime Engineering, The Institution of Civil Engineers, Issue MAO |
16 | 2007 | Charhate S. B., Deo M. C., Sanil Kumar V. | Soft and Hard Computing Approaches for Real Time Prediction of Currents in a Tide Dominated Coastal Area | Journal of Engineering for the Maritime Environment. Proceedings of the Institution of Mechanical Engineers, London, M4 |
15 | 2008 | Ustoorikar K.S., Deo, M. C. | Filling up Gaps in wave data with Genetic Programming | Marine Structures |
18 | 2008 | Jain., P., Deo M. C. | Artificial intelligence tools to forecast ocean waves in real time | The Open Ocean Engineering Journal |
22 | 2008 | Charhate, S. B., Deo, M. C., Londhe S. N. | Inverse modeling to derive wind parameters from wave measurements | Applied Ocean Research |
17 | 2008 | Gaur, S., and Deo, M. C. | Real time wave forecasting using genetic programming | Ocean Engineering |
06 | 2008 | Londhe S. N. | Soft computing approach for real-time estimation of missing wave heights | Ocean Engineering |
23 | 2009 | Charhate, S. B., Deo, M. C., Londhe S. N. | Genetic programming for real time prediction of offshore wind | International Journal of Ships and Offshore Structures |
26 | 2009 | Guven, A., Azmathulla, H. Md., Zakaria, N.A. | Linear genetic programming for prediction of circular pile scour | Ocean Engineering |
24 | 2009 | Daga, M., Deo, M. C. | Alternative data-driven methods to estimate wind from waves by inverse Modeling | Natural Hazards, 49(2), 293-310 |
08 | 2009 | Guven, A. | Linear genetic programming for time-series modelling of daily flow rate | Journal of Earth Syst. Sci., 118(2), 137-146 |
19 | 2010 | Kambekar, A. R., Deo, M. C. | Wave simulation and forecasting using wind time history and data driven Methods | Ships and Offshore Structures |
20 | 2010 a | Ghorbani, M. A. , Makarynskyy, O., Shiri, J., Makarynska, D. | Genetic Programming for Sea Level Predictions in an Island Environment | International Journal of Ocean and Climatic systems |
21 | 2010 b | Ghorbani, M. A., Khatibi, R., Aytek, A., Makarynskyy, O., Shiri, J. | Sea water level forecasting using genetic programming and comparing the performance with Artificial Neural Networks | Computers and Geosciences |
12 | 2012 | Kambekar, A. R., Deo, M. C. | Wave Prediction Using Genetic Programming And Model Trees | Journal of Coastal Research, Doi: 10.2112/Jcoastres-D-10-00052.1, 28(1), 43-50 |
One of the earlier applications was done to retrieve missing informationin wave records along the west coast of India [14]. Such a need arises many times due to malfunctioning of instrument or drift of wave measuring buoy making it inoperative as a result of which data is not measured and it is lost forever. Filling up the missing significant wave height (Hs) values at a given location based on the same being collected at the nearby station(s) was done using GP. The wave heights were measured at an interval of 3 hours. Data at six locations around Indian coastline was used in this exercise. Out of the total sample size of four years the observations for the initial 25 months were used to evaluate the final or optimum GP program or equation while those for the last 23 months were employed to validate the performance and achieve gap in-filling with different quanta of missing information. It was found that both tree based and linear GP models worked in similar fashion as far as accuracy of estimation was considered. The data was made available by National Institute of Ocean Technology (NIOT) under the National Data Buoy Programme implemented by the Department of Ocean Development, Government of India from January 2000 to December 2003 ( www.niot.res.in). The initial parameters selected for a GP run were as follows: initial population size = 500; mutation frequency = 95%; crossover frequency = 50%. The fitness criterion was the mean squared error.
When the similar work was also carried out using ANN it was found that GP produces results that are marginally more satisfactory than ANN. Another exercise was also carried out especially to estimate peaks by calibrating a separate model for high wave data which showed a marginal improvement in prediction of peaks. A similar exercise was carried out by [15], albeit in altogether different area of Gulf of Mexico near the USA coastline. Gaps in hourly significant wave height records at one location were filled by using the significant wave heights at surrounding 3 locations at same time instant and the soft tool of GP and ANN. In all data spanning over 4 years was used for the study. The exercise was carried out for 4 locations in the Gulf of Mexico. The data can be downloaded from www.ndbc.noaa.gov. The typical value of the population size was 500, number of generations 15 and number of tournaments 90,00,000. The mutation and the cross-over frequency also varied fordifferent testing exercises and it ranged from 20% to 80%. The fitness criterion was the mean squared error between actual observations and corresponding predictions.
The suitability of this approach was also tried for different gap lengths ranging from 1 day to 1 month and it was concluded on the basis of 3 error measures that the accuracy of gap filling decreases with increase in the gap length. The accuracy of the results were also judged by calculating statistical parameters of the wave records without gaps filled and with gaps filled using GP model. When the gap lengths did not exceed 1 or 5 days all the four statistics were faithfully reproduced. Compared to ANN GP produced marginally better results. In both the cases Linear Genetic Programming technique was employed.
In another earlier works of GP current predictions over a time step of twenty minutes, one hour, 3 hours, 6 hours, 12 hours and 24 hours at 2 locations in the tidal dominated area of the Gulf of Khambhat along west coast of India was carried out using two soft techniques of ANN and GP and 2 hard techniques of traditional harmonic analysis and ARIMA [16]. The work involved antecedent values of current only to forecast the current for various lead times at these locations. The fitness function selected was the mean square error, while the initial population size was 500, mutation frequency was 95%, and the crossover frequency was kept at 50%. The authors concluded that the model predictions were better for alongshore currents and small interval of times. For cross shore currents ARIMA performs better than ANN and GP even at longer prediction intervals. In general the three data driven techniques performed better than harmonic analysis. The new technique GP performed at par with ANN if not better. Perhaps the only drawback of the work was that the data (spanning over 7 months) is less than a year indicating that all possible variations in data set were not presented while calibrating the model making it susceptible when it is used at operational level.
Online wave forecasts over lead times of 3, 6, 12 and 24 hours were carried out at two locations in the gulf of Mexico using past values of wave heights (3 in number) and the soft computing technique of GP [17]. The data measured from 1999 to 2004 was available for free download on the web site of National Buoy Centre (http://www.ndbc.noaa.gov). The data belonged to the hourly wave heights measured over a period of 15 years with an extensive testing period of about 5 years which is the most in the papers reported till this time (with ANN as modeling tool). The locations chosen were differing to a large extent in that one was a deep water buoy and the other was a coastal buoy. The work was different from others in one aspect that monthly models were developed instead of routine yearly models. However any peculiar effect of this either good or bad on forecasting accuracy was not evident from the 3 error measures calculated. Though the results of GP were promising (high correlation coefficients for 3 and 6 hr forecast) the forecasting accuracy decreased for longer lead times of 12 hr and 24 hr. It was found that the results of GP were superior to ANN. For GP model the initial population size was 500 while the number of generations was 300. The mutation frequency was 90 percent while the cross over frequency was 50 percent. Values of these
control parameters were selected initially and thereafter varied in trials till the best fitness measures were produced. The fitness criterion was the mean squared error between the actual and the predicted value of the significant wave height. Another exercise on real time forecasting of waves for warning times up to 72 hours at three locations along the Indian coastline using alternative techniques of ANN, GP and MT was carried out by [18]. The data was measured from 1998 to 2004 by the national data buoy program (www.niot.res.in). Forecasting waves up to 72hr and that too with reasonable accuracy is itself a specialty of this work. The data had many missing values which were filled by using temporal as well as spatial correlation approaches. Both MT and GP results were competitive with that of the ANN forecasts and hence the choice of a model should depend on the convenience of the user. The selected tools were able to forecast satisfactorily even up to a high lead time of 72 hrs. The authors have rightly stated that this accuracy was possible in the moderate ocean environment around Indian coastline where the target waves were less than around 6 m and 2.5 m for the offshore and coastal stations respectively. The paper does not provide any information about the initial parameters chosen for implementing GP. The significant wave height and average wave period at the current and subsequent 24 hr lead time were predicted from continuous and past 24-hourly measurements of wind speeds and directions as well as two soft computing techniques of GP and MT [19]. The data collected at 8 locations in Arabian Sea and Indian Ocean (www.niot.res.in) was used to develop both hind-casting and forecasting models. Both the methods, GP and MT, performed satisfactorily in the given task of wind wave simulation as reflected in high values of the error statistics of R, R2, CE and low values of MAE, RMSE and SI. This is noteworthy since MT is not purely non-linear like GP. Although the magnitudes of these statistics did not indicate a significant difference in the relative performance of GP and MT, qualitative scatter diagrams and time histories showed the tendency of MT to better estimate the higher waves. Forecasting at higher lead times were fairly accurate compared to the same at lower ones. In general the performance of wave period was less satisfactory than that of wave height and this can be expected in view of a highly varying nature of wave period values. For details regarding the initial GP parameters involved in calibration readers are referred to the original paper where an exhaustive list of parameters is given. Lately [12], extended their earlier work by forecasting Significant wave height and zero cross wave period over time intervals of 1 to 4 days using the current and previous values of wind velocity and wind direction at 2 locations around the Indian coastline. It was found out that best results were possible when the length of the input sequence matched with that of the output lead time. As observed earlier here also it was found that the accuracy of prediction decreases with increase in lead time. However the results were satisfactory for 4 days ahead predictions also. In general it was observed that results of MT were slightly inferior to that of GP. Separate models were also developed to account for the monsoon (rainfall season in India) which showed a considerable improvement over yearly models. The models calibrated at one location when applied for another nearby locations also shown satisfactory performance provided both sites have spatial homogeneity in terms of openness, long offshore distances and deep water conditions. This work used tree based GP where as earlier mentioned three works used Linear Genetic Programming.
GP was used to forecast sea levels averaged over 12 h and 24 h time intervals for time periods from 12 to 120 h ahead at the Cocos (Keeling) Islands in the Indian Ocean [20]. The model produced high quality predictions over all considered time periods. The presented results demonstrates the suitability of GP for learning the non-linear behavior of sea level variations in terms of the R2(with values no lower than 0.968), MSE(with values generally smaller than 431) and MARE(no larger than 1.94%). This differs from earlier applications particularly for wave forecasting in that for forecasting of waves it was difficult to achieve higher order accuracy in terms of r, rmse and other error measures for as far as 24 hour forecast. Perhaps the recurring nature of sea water levels (the deterministic tidal component which is inherent in water level, is the reason behind this high level accuracy. In order to assess the ability of GP model relative to that of the ANN technique, a comparison was performed in terms of the above mentioned statistics. The developed GP model was found to perform better than the used ANNs. In the current work, the linear genetic programming approach was employed. The water level at Hillary’s Boat Harbor, Australia was predicted three time steps ahead using time series averaged over 12hr, 24hr, 5 day and 10 day time interval and the soft tool of GP [21]. The results are compared with ANN. Total 12 years of data was used out of which 3 years of data is used for model validation. Tree based GP was used. The results of 12 hr averaged input data were found to be better than 24 hr averaged input data and in general the accuracy of prediction reduced for higher lead times. For both the cases GP results were better than ANN. For 5 day averaged inputs performance of GP was inferior to that of ANN though it improved for 10 day averaged inputs. It may be noted that the input data is averaged over 12hr, 24hr, 5days and 10 days which means there is possibility of loss of information which can be major draw back of this work. For both the above works the hourly sea-level records from a SEA-level Fine Resolutions Acoustic Measuring Equipment (SEA-FRAME) station were used. The information about initial parameters of GP is however not mentioned in both the works.
Estimation of wind speed and wind direction using the significant wave height, zero cross wave period, average wave period and the soft tools of ANN and GP was carried out at 5 locations around Indian coastline [22]. The paper has three folds in that in the first attempt both ANN and GP were tried for estimating the wind speed in which GP was found better and therefore in the second fold GP was only used to determine both wind speed and direction by calibrating the model by splitting of wind vector into two components. Two variants of GP, one based on Tree based approach and the other on Linear Genetic Programming were also tried though the accuracy of estimation for both the approaches was at par. In the third fold a network of wave buoys were formed and wind direction and wind speed at one location was estimated using the same at other locations. This was also done by combining data of all locations and making a regional model. All the attempts yielded highly satisfactory results as far as accuracy of estimation is considered. It was also confirmed that for estimation of only wind speed the non-splitting of wind velocity gives better results. Similarly wind speed and its directions were predicted for intervals of 3hr, 6hr, 9hr, 12hr and 24 hr at locations along the west coast of India using two soft computing techniques of ANN and GP and previous values of the same [23]. It was found that GP rivaled ANN predictions at all the cases and even bettered it particularly for open sea location. The results for prediction of wind speed and wind direction together were better when training of GP and ANN models was done on the basis of splitting of wind vector into two components along orthogonal directions although a separate model for wind speed alone was better (as shown by [22]). In general long interval predictions were less accurate compared to short interval predictions for both the techniques. Data for one location was for about 1.5 years while for the other location it was for 3 years. A discussion on appropriate use of statistical measures to assess the model accuracy was also presented. A similar work was carried out to estimate the wind speed at 5 locations around the Indian coastline using the wave parameters and 3 data driven techniques namely GP (program based- tree type), MT and another data driven tool of Locally weighted projection regression (LWPR) by [24]. All models showed tendency to underestimate higher values in given records. When all of the eight error statistics employed were viewed together, no single method appeared distinctly superior to others, but the use of an average evaluation index EI which they have suggested in this work gave equal weightage to each measure showed that the GP was more acceptable than other methods in carrying out the intended inverse modeling. Separate GP models were developed to estimate higher wind speeds that may be encountered in stormy conditions. At all the locations, these models indicated satisfactory performance of GP although with a fall in accuracy with increase in randomness. For all the above works the data was measured by national data buoy program of India (www.niot.res.in) however no mention is made about the initial parameters chosen for GP implementation.
The estimation of longshore sediment transport rate at an Indian location was carried out using GP and combined GP-ANN models [25]. The data was actually measured by one of the authors in his field study. The inputs were significant wave height, zero cross wave period, breaking wave height, breaking wave angle and surf zone width. The limitation of the work was the amount of data (81) used for training and testing of the models. The choice of control parameters was as follows: initial population size = 500; mutation frequency = 95%; crossover frequency = 50%. The initial trial with GP yielded reasonable results (r = 0.87). However by first training the ANN with same inputs and using the output as input for GP model yielded better results ( r = 0.92). Thus the paper shows that combined ANN-GP model is more attractive than single GP model. It may be noted this is a kind of work done in the domain of Ocean Engineering wherein a different parameter (sediment transport rate) is modeled rather than the usual parameters of waves, periods etc. Another different work was carried out by [26], for prediction of scour depth due to ocean/lake waves around a pile/pier in medium dense silt and sand bed using Linear Genetic Programming and Adaptive Neuro-Fuzzy Inference system and measured laboratory data. For initial GP parameters readers are referred to actual paper where in an exhaustive list of parameters is provided. The study was carried out in both dimensional and non-dimensional form in which non-dimensional form yielded better results. The relative importance of input parameters on scour process was also investigated by first using all the influential parameters as inputs and then removing them one by one and observing the results. The drawback of the work is perhaps the small number of data used in model making (total 38 data, 28 of which is used for training the model) which may be impediment in operational use of this model. The results were found to be superior to ANFIS results.
In all the above cases where GP is compared with another data driven technique like ANN, MT or LWPR it was found that GP is superior to all of them in terms of accuracy of results. However it can be said that GP needs to be explored further particularly for prediction of extreme events like water levels, wave heights during hurricanes. A detailed study on effect of variation of GP control parameters like initial population, mutation, crossover percentage etc. on model accuracy is now need of the day. Similarly the critic on other approaches about decreasing forecasting accuracy with increase in the lead time seems to be true for GP as well. This needs more attention if GP is here to stay.
Table 2 exhibits the applications of GP in Hydrology chronologically which are reviewed in this paper. The table also indicates that the applications of GP to the field of Hydrology started much earlier as compared to Ocean Engineering.
REF. NO. | YEAR | AUTHOR | TITLE OF PAPER | JOURNAL/PUBLICATION |
27 | 1999 | Savic A.D., Walters, G. A., Davidson J.W | A genetic Programming approach to rainfall-runoff modeling | Water Resources Management |
28 | 1999 | Drecourt J | Application of Neural Networks and Genetic Programming to Rainfall Runoff Modeling. | Danish Hydraulic Institute (Hydro-Informatics Techonologies - HIT) |
29 | 2001 | Whigham, P. A., Crapper, P. F. | Modeling rainfall runoff using Genetic Programming | Mathematical and Computer Modelling, |
30 | 2001 | Khu, S. T., Liong, S. U., Babovic, V., Madsen, H., Muttil, N. | Genetic Programming And Its Application In Real-Time Runoff Forecasting | Journal of American Water Resources Association |
31 | 2002 | Babovic, V., Keijzer, M. | Rainfall runoff modeling Based on Genetic programming | Nordic Hydrology |
32 | 2007 | Sivapragasam,C., Maheswaran, R., Venkatesh, V. | Genetic programming approach for flood routing in natural channels | Hydrological processes |
33 | 2007 | Parasuraman, K., Elshorbagy, A., Carey, S. K. | Modelling the dynamics of the evapotranspiration process using genetic Programming | Hydrological Sciences |
34 | 2010 | El. Baroudy, I., Elshorbagy, A., Carey, S. K., Giustolisi., O., Savic, D | Comparison of three data-driven techniques in modeling the evapotranspiration process | Journal of Hydroinformatics |
13 | 2010 | Londhe, S. N. and Charhate S. B. | Comparison of data driven modeling techniques for river flow forecasting | Hydrological sciences |
35 | 2011 | Azmathullah, MD., Ghani, A. AB., Leow, C. S., Chang., C. K., Zakaria, N. A. | Gene-Expression Programming for the Development of a Stage-Discharge Curve of the Pahang River | Water Resource Management |
Genetic Programming is used in Hydrology (science of water) for various purposes such as modeling of phenomena like rainfall-runoff process, evapo-transpiration, flood routing, stage-discharge curve. The GP approach was applied to the flow prediction of the Kirkton catchment in Scotland (U.K.) [27]. The results obtained were compared to those attained using optimally calibrated conceptual models and an ANN. The data sets selected for the modeling process were rainfall, streamflow and Penman open water evaporation. The data used for calibration was of 610 days while that of validation was of 1705 days. The models were developed with preceding values of rainfall, evaporation and stream flow for predicting stream flow one time step ahead. Two conceptual models as well as ANN were employed for developing the stream flow forecasting model. It was observed that the rainfall data was the most influencing factor on the output. All models performed well in terms of forecasting accuracy with GP performing better. The paper does not give any details about the values of the parameters used for calibration of GP model. In another work one day ahead forecasting of runoff knowing the rainfall and runoff of the previous days and the soft computing tool of Linear Genetic Programming was carried out in Lindenborg catchment of Denmark by [28]. The models were developed for forecasting runoff as well as variation of runoff by using previous values of variation of discharge as input as well as previous values of discharge as input along with rainfall information. It was found that it was necessary to include information of discharge rather than variation of discharge. The model predicting discharge gave wrong local peaks in the low regime where as models predicting variation of discharge gave less wrong peaks in the low flow. Both the models had difficulty in predicting high peaks. The models were also developed using ANN. The author concluded that GP is more efficient in peak flow prediction where as ANNs were better in dealing with the noise. The author suggested specialized model for each type of flow to improve the accuracy at peak prediction. He also suggested coupling of black box models with gray models. No specific information is provided about the initial values of GP parameters. The rainfall-runoff relationship in two different catchments was discovered by [29] using GP. The results obtained with a deterministic lumped parameter model, based on the unit hydrograph approach were compared with those obtained using a stochastic machine learning model of GP. For the Welsh catchment in UK, the results between the two models were similar. Since rainfall and runoff were highly correlated, the deterministic assumption underlying the IHACRES model (deterministic) was satisfied. Therefore, IHACREX could achieve a satisfactory correlation between calibration and simulation data. The GP approach which did not require any causal relationships achieved similar results. The behavior of the studied Australian catchment is very different from the Welsh catchment. The runoff ratio was very low (7%), and hence, the a priori assumptions of IHACRES (and other deterministic models) were a poor representation of the real world. This was demonstrated by the inability of IHACREJS to use more than one season’s data for calibration purposes and only able to use data from a high rainfall period. Since the GP approach did not make any assumptions about the underlying physical processes, calibration periods over more than one season could be used. These led to significantly improved generalizations for the modeled behavior of the catchment. In summary, either approach worked satisfactorily when rainfall and runoff were correlated. However, when this correlation was poor, the CFG-GP had some advantages because it did not assume any underlying relationships. This is particularly important when considering the modeling of environmental problems, where typically the relationships are nonlinear, and are often measured at a scale which does not match with conceptual or deterministic modeling assumptions. Readers are referred to original paper for details of parameters setting for evolving the rainfall-runoff model. In their work of GP in hydrology, [30] first used a simple example of the Bernoulli equation to illustrate how GP symbolically regresses or infers the relationship between the input and output variables. An important conclusion from this study was that non-dimensionalizing the variables prior to symbolic regression process significantly enhance the success of GSR (Genetic Symbolic Regression). GP was then applied to the problem of real-time runoff forecasting for the Orgeval catchment in France. GP functions as an error updating procedure complementing the rainfall-runoff model, MIKE11/ NAM. Ten storm events were used to infer the relationship between the NAM simulated runoff and the corresponding prediction error. That relationship was subsequently used for real-time forecasting of six storm events. The results indicated that the proposed methodology was able to forecast different storm events with great accuracy for different updating intervals. The forecast hydrograph performs well even for a long forecast horizon of up to nine hours. However, it was found that for practical applications in real-time runoff forecasting, the updating interval should be less than or equal to the time of concentration of the catchment. The results were also compared with two known updating methods such as the auto-regression and Kalman filter. Comparisons showed that the proposed scheme, NAM-GSR, is comparable to these methods for real time runoff forecasting. Readers are referred to original paper for details of initial values of various parameters used in calibrating the GP model. The rainfall-runoff models were created on the basis of data alone as well as in combination with conceptual models and Genetic Programming [31]. The study was carried out in Orgeval catchment of France having an area about 104 km2 using hourly rainfall runoff data of 10 storms for calibration and 6 storms for testing the models. The models were calibrated to forecast the temporal difference between the current and future discharge rather than absolute value of discharge for the lead times of 1 to 12 hours. In fact the paper discusses the phase lag associated with temporal time series forecasting models and removal of it by forecasting the temporal difference. The results were superior to conceptual numerical model. The model was then calibrated using a hybrid method in that the surface runoff value was first forecasted by using a conceptual forecasting model and then using the simulation error and GP to forecast the stream flow. The hybrid models provided a many fold improvement over the raw GP models. The paper in our opinion serves as a basic paper in the field of application of GP in Hydrology and readers may read the paper in original for all details about the GP models developed. The details are not produced here to save the space. Linear Genetic Programming technique was used to predict daily river discharge one day ahead using previous values of the same at SchuylkillRiver at Berne, PA, USA [8]. Additionally the models were developed using multilayer perceprton as well as Generalized Regression Neural Networks (GRNN). The statistical ARMA method was also used to develop the stream flow forecasting model. The results showed that both LGP and NN techniques predicted the daily time series of discharge with quite good agreement as indicated by high value of coefficient of determination and low values of error measures with the observed data. LGP models generally predicted the maximum and minimum discharge values better than the NN models though LGP results were also far from accurate. The robustness of the developed models was tested by using applied data which was neither used in training or testing and the results were judged using Akaike Information Criterion (AIC). For LGP parameters readers are requested to refer the comprehensive list presented in the paper.
The potential of the GP-based model for flood routing between two river gauging stations on river Walla in USA was explored for single peaked as well as multi-peaked flood hydrographs by [32]. The accuracy of GP models was far superior than modified Muskingum method which is a traditional physics based hydrologic flood routing model which also showed time lag in predictions. The inputs were current and antecedent discharge at upstream station and antecedent discharge at downstream station while the output was current discharge at the downstream station. The LGP was employed for the flood routing exercise. The optimal GP parameters used in this study were: crossover rate, 0.9; mutation rate, 0.5; population size, 200; number of generations, 500; and functional set, i.e. simple arithmetic functions (plus, minus, multiply, divide).
The utility of genetic programming in modeling the eddy-covariance (EC) measured evapo-transpiration flux was investigated by [33]. The performance of the GP technique was compared with artificial neural network and Penman-Monteith model estimates. EC measured evapo-transpiration fluxes from two distinct case-studies with different climatic and topographic conditions were considered for the analysis and latent heat is modeled as a function of net radiation, ground temperature, air temperature, wind speed and relative humidity. Results from the study indicated that both data-driven models (ANN and GP) performed better than the Penman-Monteith method. However, the performance of the GP model is comparable with that of ANN models. One of the important advantages of employing GP to model evapo-transpiration process is that, unlike the ANN model, GP resulted in an explicit model structure that can be easily comprehended and adopted. Another advantage of GP over ANN was found that unlike ANN, GP can evolve its own model structure with relevant inputs reducing the tedious task of identifying optimal input combinations. This work was extended by [34] where in an additional data driven tool of Evolutionary Polynomial Regression was used to model the evapo-transpiration process. Additionally the effect of previous states of input variable (lags) on modeling the EC measured AET (actual evapo‐transpiration) is investigated. The evapo-transpiration is estimated using the environmental variables such as net radiation (NR), ground temperature (GT), air temperature (AT), wind speed (WS) and relative humidity (RH). It has been found out that random search and evolutionary-based techniques, such as GP and EPR techniques, do not guarantee consistent performance in all case studies e.g. good and/or bad performance for modelling AET. The authors further stated that this may be due to the practical impossibility of conducting exhaustive search, i.e. searching the entire solution space, to reach the optimal model. The results of ANN, GP and EPR were mostly at par with each other though EPR models were easier to understand. Readers may refer the original papers for above two works for the values of GP parameters.
Recently the stage –discharge relationship for the Pahang River in Malaysia was modeled using Genetic Programming (GP) and Gene Expression Programming (GEP) by [35]. The data was provided by Malaysian Department of Irrigation and Drainage (DID). Gene Expression Programming is an extension of GP. GEP is a full-fledged genotype/phenotype system in which both are dealt with separately, whereas GP is a simple replicator system. Stage and discharge data from 2 years were used to compare the performance of the GP and GEP models against that of the more conventional (stage-rating curve) SRC and (Regression) REG approaches. The GEP model was found to be considerably better than the conventional SRC, REG and GP models. GEP was also relatively more successful than GP, especially in estimating large discharge values during flood events. For details of initial GP parameters the original paper may be referred. The paper elaborates the details of the Gene-expression programming, the new variant of GP.
Like applications in Ocean Engineering it can be said that there is a lot of scope for use of GP in the field of Hydrologic Engineering and more and more applications needs to be tried out.
A few applications of GP in Hydraulic Engineering are also reported in reputed journals which are from open channel hydraulics. Various GP models were developed by [36] to predict velocities across a compound channel with vegetated floodplains. The velocity data was collected in a laboratory flume with steady flow and deep channel and relatively shallow vegetated floodplain on either side. The GP model was developed with all 12 variables in dimensional form depicted accurate results though the evolved equation was complex. The GP models were developed with dimensionless variables and separate for main channel and floodplain. Both the velocity prediction on flood plain and main channels showed good correlations with measured values. However the resulting expressions were complex. A dimensionally aware GP was then used to predict the velocity separately in main channel and flood plains. The performance of the symbolic expressions induced by the dimensionless GP for the floodplain and main channel was marginally better than those for the dimensionally aware GP. However, the expressions were more complex and not particularly useful for knowledge induction. The dimensionally aware GP was shown to hold more scientific information, as units of measurement were included, although it was also shown to be open ended in that it does not strictly adhere to the dimensional analysis framework, thereby allowing improved goodness-of-fit whilst yielding on goodness-of-dimension. The paper provides no information about the initial values of GP parameters used in evolving the GP model. GP was applied to the determination of the Chezy’s roughness coefficient for corrugated channels in wake-interference flow, i.e. hyper-turbulent flow by [37]. The GP models were calibrated using the experimental data devised by carrying out experiments for 3 plastic corrugated pipes with variations of discharge and slope. GP quite easily and quickly supplied at least two good formulae that fit the experimental data better and are more parsimonious than the monomial formula (mathematical). Moreover, GP has supplied six parsimonious expressions (one or two constants compared to four for the monomial formula) for the Chezy’s resistance coefficient, all confirming the dependencies on hydraulic radius, slope and roughness index. It can be said that the two new formulae for the Chezys resistance coefficient, derived from these GP formulae by means of ‘mathematical/physical post-refinement’, are suitable for explaining the effect of the macro-roughness elements, with respect to the behavior of the rough commercial channels and their traditional expressions for resistance coefficients. The work indicated that this approach, which combines data-mining techniques together with a theoretical understanding, provides very good results. It was also commented that strictly speaking, GP is a data-driven technique, but prior knowledge during the setting up of the evolutionary search and final physical post-refinement of the hypothesis should make it very close to a white box technique, especially when GP is used in scientific discovery problems. The initial model parameters can be found in the original paper. To save space the list is not provided here.
An alternative approach of GP was proposed in the estimation of relative scour depth using field data by [38]. The comparison between the GP model with ANN found that the GP model has good ability of forecasting the scour depth. The discharge intensity and height of fall were used as inputs to estimate scour depth below tail water. The predictive ability of this approach is however clouded by use of very small number of data (total 91 data sets) used for calibration and testing of the model. The values of initial model parameters can be referred from the original paper.
The work dealt with application of GP to retrieve the missing/ lost wave data at a particular location using the wave heights at other locations in the region. Six regional networks (with buoys 42001, 42003, 42007, 42036, 42039,42040) were developed in the Gulf Of Mexico (Figure 2) around USA coastline to estimate the wave heights at a location using wave heights at other five locations in the network. The required data from these six buoys was measured by NationalDataBuoyCenter (NDBC, http://www.ndbc.noaa.gov) of National Oceanic and Atmospheric administration of USA (NOAA, http://www.noaa.gov ). The common wave data at all the above six locations for the years 2002-2004 was used in the present work. The networks were developed by having one station as target location at a time and remaining five locations as inputs turn by turn. Approximately 70% of the total values were used to calibrate the model and the remaining was kept unseen for testing. While doing this a particular event which occurred during Hurricane Ivan in 2004 at buoy 42040 which involved a Significant Wave Height of 15.96 m was focused for studying the performance of developed models during extreme events. It is to be noted that the exercise was of estimation and not of forecasting for which both the tools did not performed well as noted in the section on applications of GP in Ocean Engineering.
Thus a network was developed with wave buoy 42040 as the target and buoys 42001, 42003, 42007, 42036, 42039 as inputs. Along with 42040 the other locations namely 42003, 42007, 42039 also experienced largest ever wave heights of 11.04, 9.09, 12.05 making the entire event a truly extra ordinary event having a return period of over 5000 years [39]. The initial parameters selected for a GP run were as follows: initial population size 500, mutation frequency 95%, and crossover frequency 50%. The fitness criterion was the mean squared error.
Additionally a three layer Feed Forward Neural Network was also developed for the same buoy network. The results were also compared with a large-scale continuous wave modeling /forecasting systems (NOAA’s WAVEWATCH III model) which follows the approach of physics-based model. Though WAVEWATCH III is a continuous running forecasting model it was the only source of information for wave environment at a location and therefore in absence of any reliable observed data, these results were used for comparison. The GP model estimated a wave height of 13.67m as against 15.96 m as compared to 9.05m that of ANN model and 7.82m of WAVEWATCH III, which was an excellent result as far as GP approach is considered. Figure 3 shows the wave plot at 42040 in testing.
From results of all the models developed by both the approaches (ANN & GP), it was observed that all models performed reasonably well in testing as evident by wave height plots, scatter plots along with the correlation coefficient ranging from 0.85 to 0.98, MAE from 0.13 to 0.28, RMSE from 0.20 to 0.45 m and coefficient of efficiency from 0.67 and 0.96. When it was tried to remove 42001 from the network as it is away from the prevailing wind direction by training a separate GP model with 42003, 42007, 42036, and 42039 as ‘input buoys’ and 42040 as ‘target buoy’, though the value of correlation coefficient was increased, the peak prediction was not in a fair range of accuracy for extreme event of Hurricane Ivan. Due to better performance of the network with inclusion of buoy 42001 especially for extreme event, buoy 42001 was retained in the network. Also it was found that 42039 was a potential candidate for redeployment in any other suitable position outside the network as the buoy network developed for 42039, provided the wave heights using wave heights at other five locations in the network with the best accuracy achieved between all the networks (r = 0.98). Figure 4(a, b) shows the scatter plots for results of buoy 42039. Table 3 shows results reproduced from [6] giving the details of developed networks along with correlation coefficient between the model estimated and observed values for both GP and ANN models. In general it was shown that GP was superior to other soft tool of ANN and numerical model WAVEWATCH in retrieving the missing wave heights including the extreme events and in redeployment of buoy at other location outside the network.
Study area and Buoy Locations (Ref: [
Wave height comparison at 42040 during Hurricane Ivan (Ref: [
a. Scatter plot for buoy 42039 (GP approach); b. Scatter plot for buoy 42039 (ANN approach) (Ref: [
BN1 | 42003, 42007, 42036, 42039, 42040 | 42001 | 0.85 | 0.88 |
BN2 | 42001, 42007, 42036, 42039, 42040 | 42003 | 0.87 | 0.91 |
BN3 | 42001, 42003, 42036, 42039, 42040 | 42007 | 0.90 | 0.92 |
BN4 | 42001, 42003, 42007, 42039, 42040 | 42036 | 0.92 | 0.94 |
BN5 | 42001, 42003, 42007, 42036, 42040 | 42039 | 0.98 | 0.98 |
BN6 | 42001, 42003, 42007, 42036, 42039 | 42040 | 0.94 | 0.97 |
Results of buoy networks [6]
In the case study GP was used for prediction of average daily flow values one day in advance at two locations, Rajghat and Mandaleshwar, in the Narmada basin, India using the previous values of measured streamflows at these two locations. The observations of daily average stream flow values at both these stations for the years 1987–1997 were obtained from the Central Water Commission, Narmada Division, Bhopal, India. Considering the variations in daily stream flow values four separate models for the monsoon months of July, August, September and October were prepared along with the one separate but common model for the non monsoon months of November–June. Thus five models were developed in all for each station (total 10 models) to predict discharge at one day in advance. In a view of fair judgment along with GP, ANN and Model trees approach was also employed to develop the models. The number of antecedent discharge values which were used for predicting discharge one day in advance was decided by carrying out the auto-correlation analysis.
The GP models were developed with major fitness function of mean squared error, initial population size of (2048), mutation frequency of (95%) and the cross-over frequency of (53%) with same data division for both ANN and GP models so that their results could be compared. All the developed forecasting models were tested for unseen inputs and their qualitative and quantitative performance was judged by means of correlation coefficient (r) between the observed and forecasted values along with root mean square error (RMSE) and plotting scatter plots between the same. Hydrographs were also plotted to visualize the behavior of the forecasting models particularly for extreme events (peaks).
After examining the results it was observed that for the location of Rajghat in the month of July, ANN model exhibited a reasonable performance in testing with an ‘r’ value of 0.75 between the observed and forecasted discharges whereas GP model had showed a better ‘r’ value of 0.78 with better performance for higher values of stream flow, though over-predicted in some instances. The MT model gave a lower ‘r’ value of 0.7 and prediction of MT model for high stream flows was poor as compared to ANN and GP models. The scatter plot (Fig. 5) between the observed and forecasted discharges confirmed this with a balanced scatter except at the high values of measured stream flows.
Scatter plot for RajJuly Model
For the months of August and September, models showed similar performance with GP models performing better than their ANN and MT counterparts (r GP = 0.75,rANN = 0.7, r MT = 0.72 for Raj Aug and r GP = 0.79,rANN = 0.76, r MT = 0.78 for Raj Sept). For the October model, the predicted discharges in testing were highly in agreement with the observed values for both the models as shown by the discharge hydrograph (Fig. 6). The results were also supported by a high value of correlation coefficient (r = 0.92 for ANN and GP and r = 0.87 for MT) for all the three models in testing.
The Mandaleshwar models behaved in a similar fashion as that of the Rajghat models with correlation coefficients of r > 0.7 for all ANN, GP and MT models. For the month of August the performance of all models was reasonable with r values of 0.74, 0.78 and 0.71 for ANN, GP and MT models respectively. The other monthly models of ANN, GP and MT also performed well, with high correlation coefficients in testing (r > 0.86). It was again observed that GP models work better while predicting extreme events. The maximum observed discharge of 3790 m3/s was predicted as 1742 m3/s by the ANN model, 3342 m3/s by the GP model and 1718 m3/s by the MT model. Figure 7 shows discharge hydrographs for the ManNov-June models. The RMSE values also showed a similar trend to that of the correlation coefficients.
Thus it was seen that the GP technique outperforms both ANN and MT in almost all the cases in terms of overall accuracy in prediction. The GP approach based on evolutionary principles has a completely different approach to the ANN technique in that it does not involve any transfer function, and evolves generations of “offspring” based on the “fitness criteria” and genetic operations; this seems to capture the underlying trends better than the ANN technique. Thus it can be said that ANN and MT perform almost equally but GP performed better than both of them where prediction accuracy in both normal and extreme events is concerned.
RajOct Model results [
ManNovJune Model results [13]
Applications of GP for modeling water flows were discussed in the preceding sections of this chapter. It may be noted that every attempt is made to provide readers the details of GP techniques and their parameters employed in each work. However in view of keeping the length of the chapter in stipulated limits sometimes the readers are referred to the original paper. Details about the data are also provided at appropriate locations. Interested readers may further enquire the authors or download the data whenever possible from the web sites to perform the similar exercise. The applications were from three particular areas of water flows namely Ocean Engineering, Hydrology and Hydraulics. It was shown in all the applications for that modeling of natural random processes of complex underlying phenomenon the Genetic Programming can certainly be employed. The results of this technique were found to be superior than other contemporary soft computing techniques. However it was also seen that the tool is not explored to its full capacity by the research community in any of the above fields. The developed GP models also need to be applied at operational level. For this a partnership between the researchers and practitioners is necessary. The GP models can certainly work as supplementary tool if not as replacement techniques. It can be said that the early days of GP modeling are over and the tool needs to be used more judiciously for the problems worthy of its use. Otherwise a stage will be reached where in GP will be used because data is available. It’s use is certainly for the phenomena which are difficult to explain and model. However if the technique is to stay here it needs to be explored further for more challenging problems like modeling of infiltration, high flood events, hurricane path, storm surge, tsunami water levels to name a few.
The heart has an intrinsic conduction system that consists of specialized cells. It can spontaneously depolarize to initiate heartbeats from its rhythmic pacing discharge and coordinate heart electrical activity [1, 2]. The sinoatrial (SA) node is the first pacemaker that starts the electrical impulse resulting in the depolarization and contraction of the atrium. This electrical impulse is distributed throughout the heart through the internodal pathway, atrioventricular (AV) node, AV bundle, branches of the bundle of HIS, and through Purkinje fibers. Without the extrinsic (hormonal and neural) influences, the SA node creates about 100 beats per minute; however, to meet the body’s oxygen requirement under variable conditions, cardiac output (and thus heartbeat) must vary. This is where the autonomic nervous system (ANS) of the heart plays a role [2].
The heart receives extensive innervation by both sympathetic and parasympathetic systems of the ANS. The cardiac efferent preganglionic sympathetic neurons originate from the lateral horns of the spinal cord’s upper thoracic segment (T1-T4) and leave the spinal cord through the ventral (anterior) roots of the corresponding spinal cord nerves. As they reach the superior cervical, medial cervical, cervicothoracic/stellate, and thoracic ganglia of the paravertebral sympathetic nerve chain (SNC), they synapse onto the postganglionic nerves, namely the cardiac cervical nerves and cardiac thoracic nerves, which travel to the heart along with the epicardial vascular structure [1, 2, 3, 4].
The cardiac efferent preganglionic parasympathetic neurons originate in the medulla oblongata’s dorsal motor nucleus and nucleus ambiguus. They travel bilaterally within two vagal nerves and synapse onto the postganglionic nerve fibers in the vagal nerve ganglia located in the cardiac plexus, at the base of the heart [3, 4]. Cardiac plexus consists of a complex network of various nerves including the sympathetic, parasympathetic, and cardiac nerves as well as some tiny parasympathetic ganglia to control cardiac activity. The cardiac plexus is divided into two parts: (1) the superficial part located in the aortic arch concavity and (2) the deep part located between the trachea and the aortic arch. Both parts are connected to provide cardiac autonomic innervation [3].
Most of the cardiac afferent fibers travel in sympathetic cardiac nerves. The first-order sympathetic-sensitive afferent fibers have their cell bodies in the first 4–5 thoracic ganglia. They synapse with the second-order fibers in the spinal cord, where they cross the median line and ascend along the anterior spinothalamic tract (ventral spinothalamic fasciculus) to the posteroventral nucleus in the thalamus. Parasympathetic afferent fibers in the heart primarily function as a mediator for some cardiac reflexes, responding to activation of stretch receptors in the atria (Bainbridge reflex) and left ventricle (Jarisch-Bezold reflex) [3].
The ANS influences most heart functions by affecting the SA node, AV node, myocardium, and small and large vessel walls [2]. The ANS regulates heart rate (chronotropic effect), myocardial cells contractility (inotropic effect), signal conductivity (dromotropic effect), excitability (bathmotropic effect), as well as coronary vascular tone and myocardial blood flow. As the sympathetic and parasympathetic systems have opposite effects on heart functions, the final effect on the heart is the net balance between the two systems. However, their influence differs by their distribution in the heart [2, 3].
The sympathetic system carries an excitatory effect on heart functions and is activated in emergency, stressful situations, or any other situations that require increase of cardiac output; therefore, it is also known as “fight or flight response” [2]. It controls heart function mainly in three effects: (1) It speeds up the depolarization of the sinus node increasing heart rate (positive chronotropic), (2) increases conduction velocity in the AV junction, atria, and ventricles (positive dromotropic effect), (3) increases myocardial contractility both in the atria and ventricle (positive inotropic effect) [2, 3]. Most of these effects are mainly mediated by the β1 adrenergic receptors as they predominate in healthy human hearts, whereas β2 receptors are primarily concentrated in the atria and ventricles thus their functions are linked to the inotropic effect. Both β1 and β2 receptors are distributed in all regions of the heart, nevertheless [3]. In addition, sympathetic activation also promotes constriction of the coronary arteries leading to an increase of cardiac output, which is mediated by α1 and α2 receptors, and dilatation mediated by β2 receptors in the coronary arteries [2, 3].
Conversely, the parasympathetic (vagal) system has inhibitory effects on heart functions. It is activated under restful conditions and is therefore known as rest and digest response [2]. It slows down sinus node activity resulting in a decrease of heart rate, slows down electrical conduction through the AV nodes and conduction system, causing delayed conduction and AV block, decreases atria contractility, and promotes dilatation of the coronary arteries, which result in decreased cardiac output. On atrial cells, parasympathetic activation decreases contractility yet shortens the action potential duration causing an increase in conduction speed, thus leading to reentrant tachyarrhythmias. As parasympathetic fibers are predominantly distributed to the atria while poorly distributed to the ventricles, parasympathetic activation does not significantly affect intraventricular conduction and ventricles’ contractility. The parasympathetic system influences the heart through the M2 receptor and the coronary arteries through M3 receptors [3].
Both sympathetic and parasympathetic preganglionic neurons release acetylcholine (Ach) and are called cholinergic; however, their postganglionic release different neurotransmitters. Sympathetic postganglionic neurons release norepinephrine (which resembles epinephrine/adrenalin, thus referred to as adrenergic) while most parasympathetic postganglionic neurons release acetylcholine.3
ANS abnormalities in terms of anatomy and physiology can cause various heart abnormalities. ANS abnormalities are associated with electrical abnormalities which cause heart problems. This can cause a variety of manifestations. In this section, we will discuss more the electrical abnormalities associated with ANS abnormalities in the heart.
Ventricular arrhythmia remains a common cause of sudden cardiac death in myocardial infarction (MI) patients. Following a myocardial ischemic injury, sympathetic axon fibers within the scar become dysfunctional, degenerate, and die. However, contrary to the central neurons, peripheral neurons commonly regenerate back to their target, a phenomenon called nerve sprouting [4, 5]. This efferent sympathetic regeneration is triggered by nerve growth factor (NGF), which levels are found to be increased after MI, and causes hyperinnervation in the infracted are of the heart thereby promoting ventricular arrhythmia. Studies using 123I-meta-iodobenzylguanidine (MIBG) have shown evidence of sympathetic reinnervation in the infracted hearts after MI. A study conducted by Cao et al. [6] demonstrated that the high density of nerve fibers was significantly higher in the peripheral to the area of necrotic tissue of failed hearts. Chen and colleagues also support this phenomenon’s discovery that infusion of NGF to the stellate ganglion causes an increase of nerve density and QT interval prolongation, therefore increases and prolongs ventricular arrhythmias [4, 6, 7, 8]. Furthermore, there have been findings that demonstrate a notable decrease in parasympathetic tone in patients with comorbidities (such as coronary artery disease, MI, and diabetes) during sleep despite the unopposed sympathetic activity, creating a higher risk of ventricular arrhythmia. Another electrical phenomenon following MI that leads to ventricular arrhythmia is an occurrence of heterogeneous distribution of hyperinnervation of sympathetic nerves, particularly in the border zone (despite the remaining viable myocardial cells), which can lead to impulses and therefore initiate tachyarrhythmia. On another note, interventions that reduce sympathetic nerve activity have been shown to reduce the risk of arrhythmias in MI patients, both in humans and animals [6]. Some therapies that are suggested to reduce the risk of ventricular arrhythmia include cervical sympathectomy and spinal cord stimulation (inhibiting cardiac sympathetic tone while enhancing parasympathetic tone). Future therapies may focus on preventing nerve sprouting by inhibiting nerve growth or attaining regional cardiac denervation by ganglia ablation [4].
The influence of ANS on the pathogenesis of atrial fibrillation (AF) had been discovered since 1978 [3]. In the beginning, AF was thought to be a sympathetic-mediated phenomenon; however, studies have shown that sympathetic and parasympathetic systems may contribute to the pathogenesis. Sympathetic-mediated arrhythmia may occur because of β-adrenergic signal pathway activation, which increases Ca2+ transient. On the other hand, parasympathetic activation through Ach stimulation on muscarinic receptors (mainly M2 in the heart) causes a shortened duration of action potential (thus increasing conduction speed) in atria, causing arrhythmias [4, 9]. Studies by Scherf et al. suggested that local application of either aconitine or Ach in the heart may lead to rapid focal firing or AF, which could be terminated by removing the focal source of firing [10, 11]. Whether an AF episode is predominately sympathetic-mediated or parasympathetic-mediated may depend on comorbidities; lone and nocturnal AF (where parasympathetic is profoundly dominant) in patients with normal hearts is usually parasympathetic-mediated whereas AF in patients with organic heart disease or disorders such as phaeochromocytoma or hyperthyroidism is usually sympathetic-mediated. In addition, parasympathetic-mediated AF episodes usually occur weekly, predominantly at night, last for a few hours, and are preceded by progressive bradycardia. In contrast, sympathetic-mediated AF episodes usually occur during the daytime, during exercise, or under stress. The current primary endpoint target of the ablation procedure is the pulmonary vein isolation (PVI), thereby predisposing to reentrant phenomena and high density of nerves. However, studies have demonstrated that direct stimulation to the ganglionated plexus could result in AF, whereas ablation of the corresponding plexus may reverse the alteration of conduction speed [3, 8]. Multiple clinical studies were conducted to compare whether combining ganglionated plexus (GP) ablation with PVI or PVI alone is more effective in suppressing AF, one of which is done by Katritsis et al. l who found that combination of GP ablation and PVI showed higher success compared to PVI alone [9].
Long QT syndrome (LQTS) is characterized by prolonged ventricular repolarization (prolonged QT interval), leading to polymorphic ventricular tachycardia and, therefore, risk of sudden death. It is a heterogeneous syndrome resulting from several cardiac ion channels. Arrhythmias in LQTS patients are often emotional or physical stress-related, and sympathetic activation has been suggested as an important triggering factor. However, the response to this trigger may vary depending on LQTS syndrome. For instance, LQTS type 1 has more prominent and prolonged effects from sympathetic activation than LQTS type 2 [4]. A study has been conducted by Shamsuzzaman [12] to record sympathetic activity using muscle sympathetic nerve activity (MSNA) and skin sympathetic nerve activity (SNA). The result of the study demonstrated that in LQTS patients, the baseline of MSNA is very low and further accompanied by slower heart rates and reduced LF. In contrast, the baseline of skin SNA is normal, indicating that LQTS patients have region-specific decreased cardiac sympathetic drive. In such a setting, surges of sympathetic stimulation caused by emotional or physical stress may lead to cardiovascular events [12].
Brugada syndrome is an inherited channel disorder characterized by sodium channel abnormality (and thus ECG abnormalities) that predisposes to ventricular arrhythmias and sudden death despite structurally typical hearts [4, 13, 14]. Another exciting characteristic of Brugada syndrome is that ventricular fibrillation and sudden death mainly occur at rest or during sleep, which is the period of parasympathetic dominance. Furthermore, clinical characteristics and typical ECG changes can be variable over time and are influenced by external factors, such as exercise and pharmacological intervention. Exercise can diminish ECG signs of Brugada syndrome, while on the contrary, drugs that interact with the ANS innervation can unmask or intensify the signs. For this occurrence, studies have suggested that the ANS is involved in the natural history of the syndrome. Prior studies have shown a sympathetic-parasympathetic tone imbalance in patients with Brugada syndrome. A study by Wichter et al. demonstrated a reduced I-MIBG reuptake, either because of a reduced number or function of efferent sympathetic neurons and a reduced transporter capacity for NE reuptake, which indicated a presynaptic adrenergic dysfunction [14]. According to the authors of this study, this reduced sympathetic tone may impact protein phosphorylation and spatial calcium heterogeneity, thus leading to arrhythmias, especially in the downregulation of adrenergic activity or in parasympathetic dominance [14].
Besides electrical abnormalities, ANS also correlates with ischemic heart disease. Following a transmural myocardial infarction (MI), sympathetic fibers within the scar become denervated and die. However, denervation also occurs in the non-infarcted sites distal to the infarction early after occlusion, resulting in a neurotransmission disruption, nerve sprouting, and denervation supersensitivity even in the viable myocardium cells. Not all sites are denervated equally, this disruption leads to a heterogeneous change of effective refractory period (ERP). Together with decreased protection from vagal denervation, this leads to ventricular arrhythmias [4].
As with heart failure, myocardial dysfunction caused by cardiac insult activates neurohormonal mechanisms, including activation of the sympathetic system and the renin-angiotensin-aldosterone system (RAAS) axis. Increased activation of the sympathetic system causes an increase in NE delivery to myocardial cells. High local catecholamine level leads to ventricular hypertrophy and increase susceptibility to arrhythmia, which worsens the heart’s function and, in turn, further increases sympathetic tone [15]. This activation is initially essential to compensate for the weakened myocardial function; however, in the long term, this activation leads to further deterioration of cardiac function, worsening heart failure, and cardiac decompensation. Besides sympathetic activation, there has been evidence of reduced parasympathetic function, which further worsens heart failure. Heart failure can also cause denervation, creating nerve sprouting and electrical remodeling, leading to ventricular arrhythmia and sudden cardiac death [4, 16].
Following electrical and ischemic instability, ANS also have a direct effect on action potential duration restitution. The destabilization of activation wavefronts is associated with the alteration in action potential duration (APD) resulting from the alteration of the previous diastolic interval, called restitution. Steepened APD restitution curve slope has been associated with complex, unstable dynamics, while a decrease of the steepness of the curve by drugs may suppress ventricular arrhythmia [17, 18, 19]. A study in porcine models by Taggart et al. has shown that sympathetic stimulation with adrenaline (α – and β-adrenergic agonist) steepens the APD restitution curve [20]. The same effect was confirmed in humans with normal ventricles by a more recent study using isoprenaline (β-adrenergic agonist) and adrenaline, demonstrating that both adrenaline and isoprenaline steepen the APD restitution curve at the minimum range of 40 ms. This evidence suggests a mechanism in which the sympathetic nervous system is contributed to inducing arrhythmia and ventricular fibrillation [16]. Additionally, a study conducted in an isolated rabbit heart model demonstrated that parasympathetic activation exerts a contradictory effect, reducing the steepness of the slope, thereby suppressing ventricular fibrillation [21].
By understanding the mechanism of influence of the anatomy and physiology of the ANS heart and its influence on various heart abnormalities, we can determine the appropriate therapeutic approaches. Therapeutic approaches in neurocardiology fall into two focuses: (1) applying novel treatment and (2) interaction of non-drug and multiple drugs treatments. Patients with cardiomyopathy are suggested to have increased sympathetic innervation and decreased parasympathetic innervation; therefore, interventions aiming to reduce sympathetic tone and thereby increasing parasympathetic tone are beneficial to reduce the susceptibility of ventricular arrhythmia sudden cardiac death. Some options of approaches include the following options [4].
Multiple studies have shown that in patients with heart failure, pharmacologically inhibition of sympathetic activity may reduce the risk of sudden cardiac death. Current pharmacological therapies include β-blockers (β-receptor antagonist) and angiotensin-converting enzyme inhibitors (ACE-I), which are the mainstay approaches for early hypertension and other cardiovascular disease associated with dysautonomia [22]. Surgical techniques, for instance, sympathectomy, reduce the risk of comorbidities in patients with hypertension and reduce the incidence of ventricular arrhythmia [22].
Pharmacological therapies such as β-blockers, ACE-I, angiotensin receptor blockers (ARB), aldosterone antagonists, and statins are proven to decrease the risk of sudden cardiac death in patients with ischemic cardiomyopathy. In addition, these drugs also provide modulations of the ANS by decreasing sympathetic activity and increasing parasympathetic activity. Through baroreflex, Angiotensin II decreases vagal bradycardia. This effect can be reversed with ACEI and ARB by increasing parasympathetic output to the heart. In an experimental study using rat models with ischemic cardiomyopathy, aldosterone antagonist and ACEI showed a decrease of myocardial NE content, demonstrating an antisympathetic effect. Statin therapies show several mechanisms in normalizing sympathetic activity and cardiovascular reflex regulation, such as increased baroreceptor sensitivity for heart rate control, reducing angiotensin II-induced sympathetic responses, decreasing baseline of renal sympathetic activity, and downregulating mRNA and protein expression of Angiotensin II type I receptors as well as NADP oxidase subunits of the heart [4].
Biventricular pacing has been suggested to improve hemodynamic status in patients with intraventricular conduction delay and reduced ejection fraction and decreased sympathetic tone in patients with hypertension, thus shifting the autonomic balance of the heart to a less sympathetic more parasympathetic profile [4]. Proper cardiac resynchronization therapy (CRT), in the short term, results in left ventricular systolic function improvement and mitral regurgitation reduction, providing a more optimal ventricular filling. Over a more extended period, CRT promotes left ventricular reverse remodeling, leading to significant functional capacity, survival, and quality of life improvements [23].
Several measurements that can be used to index parasympathetic function/activity include resting heart rate, heart rate recovery (heart rate decrease following termination of exercise), heart rate variability, and baroreflex sensitivity (the responsiveness of the cardiovascular system to blood pressure changes). Several studies have shown that reduced parasympathetic function is associated with mortality and leads to risk factors for cardiovascular diseases. Those risk factors include biological factors such as hypertension, diabetes, abnormal cholesterol; lifestyle factors such as tobacco use, physical inactivity, and overweight; and non-modifiable factors such as age and family history [4].
Vagal nerve stimulation (VNS) is a non-pharmacological intervention to normalize autonomic imbalance, directly stimulating the vagus nerve to improve parasympathetic tone and reflex. VNS has been shown to improve left ventricular hemodynamics and increase heart rate variability. VNS also results in better vagal reflex and nitric oxide expression, improvement of the renin-angiotensin system, inflammatory cytokines modulation, reduced heart rate, risk of ventricular arrhythmias, and mortality [24]. A recent multinational, randomized clinical trial called INOVATE-HF (Increase of vagal tone in CHF) demonstrated that VNS significantly resulted in favorable effects on quality of life, NYHA functional class, and 6-min walking distance. However, the ventricular end-systolic volume index was not significantly different [25].
Renal efferent signals regulate renin secretion, water and sodium retention, and intrarenal vascular distribution. Efferent signals (as a response to sensory signals from renal) activate sympathetic fibers, inhibit parasympathetic fibers, and cause a release of catecholamines, which in pathology conditions such as myocardial infarction or heart failure, can increase the risk of arrhythmia [26]. Catheter-based renal denervation (RDN) is a neuromodulation treatment that includes catheter-based ablation to the renal artery wall, thus reducing the afferent and efferent sympathetic activity in the kidney and globally [26, 27, 28]. It has been used to treat drug-resistant hypertension. However, the role of RDN has also been studied as adjunctive therapy in patients with ventricular tachycardia and heart failure. By reducing circulating catecholamines, RDN reduces the electrical heterogeneity in the scarred myocardium and border zone regions and thus decreases susceptibility to ventricular arrhythmia and sudden cardiac death [26]. RDN has also been suggested to reduce blood pressure, reduce NT-proBNP, and improve NYHA class symptoms in patients with heart failure. Therefore, RDN is suggested to be favorably impactful for hypertension, MI, and heart failure [28].
The heart receives extensive innervation by both sympathetic and parasympathetic systems of the ANS. The sympathetic system carries an excitatory effect on heart functions, while the parasympathetic system has inhibitory effects on heart functions. ANS abnormalities associated with electrical abnormalities can cause a variety of heart manifestations, including ventricular arrhythmias, atrial fibrillation, Long QT Syndrome, and Brugada Syndrome. Besides electrical abnormalities, ANS also correlates with ischemic heart disease. Following electrical and ischemic instability, ANS also have a direct effect on action potential duration restitution. By understanding the mechanism of influence of the anatomy and physiology of the ANS heart and its influence on various heart abnormalities, we can determine the appropriate therapeutic approaches. Therapeutic approaches in neurocardiology fall into two focuses: applying novel treatment and interaction of non-drug and multiple drugs treatments, such as selective sympathetic blockade, cardiac autonomics modulation therapies, resynchronization therapy parasympathetic function mortality and cardiovascular risk, vagal stimulation, and renal denervation.
No one to acknowledge.
The authors declare no conflict of interest.
neurotransmitters in ANS the autonomic nervous system consists of sympathetic and parasympathetic components electrical heart abnormalities which are generally characterized by arrhythmias on electrocardiogram findings heart abnormalities based on block of the cardiac conduction system in the AV node heart node located at the atrioventricular junction compensating reaction occurring in an increase in heart rate after an increase in cardiac preload compensating reaction occurring in an increase in heart rate after an increase in cardiac preload excessive innervation bradycardia, hypotension, and apnea heart abnormalities in the form of damage to heart cells due to lack of blood supply to the cells concerned the branch of neurology that studies the nervous system of the heart The New York Heart Association’s (NYHA) functional classification system assists in classifying individuals with congestive heart failure based on their symptoms. a treatment used to treat atrial fibrillation, an irregular heart rhythm. a cluster of cells in the right atrium. These cells can deliver electrical impulses to the heart muscle cells, causing them to contract regularly and autonomously. ganglionated chain from the skull base to the coccyx refers to any procedure that stimulates the vagus nerve, whether physical or electronic.
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\n\nCURRENT PROJECTS
\n\nTo view current Open Access book projects that are Open for Submissions visit us here.
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Diseases",slug:"bacillus-based-biological-control-of-plant-diseases",totalDownloads:17398,totalCrossrefCites:65,totalDimensionsCites:153,abstract:null,book:{id:"432",slug:"pesticides-in-the-modern-world-pesticides-use-and-management",title:"Pesticides in the Modern World",fullTitle:"Pesticides in the Modern World - Pesticides Use and Management"},signatures:"Hélène Cawoy, Wagner Bettiol, Patrick Fickers and Marc Ongena",authors:[{id:"27515",title:"Prof.",name:"Patrick",middleName:null,surname:"Fickers",slug:"patrick-fickers",fullName:"Patrick Fickers"},{id:"40395",title:"Dr.",name:"Marc",middleName:null,surname:"Ongena",slug:"marc-ongena",fullName:"Marc Ongena"},{id:"108031",title:"Ms.",name:"Hélène",middleName:null,surname:"Cawoy",slug:"helene-cawoy",fullName:"Hélène Cawoy"},{id:"108032",title:"Dr.",name:"Wagner",middleName:null,surname:"Bettiol",slug:"wagner-bettiol",fullName:"Wagner Bettiol"}]},{id:"32936",doi:"10.5772/26052",title:"Phytochemicals: Extraction Methods, Basic Structures and Mode of Action as Potential Chemotherapeutic Agents",slug:"phytochemicals-extraction-methods-basic-structures-and-mode-of-action-as-potential-chemotherapeutic-",totalDownloads:95200,totalCrossrefCites:16,totalDimensionsCites:116,abstract:null,book:{id:"878",slug:"phytochemicals-a-global-perspective-of-their-role-in-nutrition-and-health",title:"Phytochemicals",fullTitle:"Phytochemicals - A Global Perspective of Their Role in Nutrition and Health"},signatures:"James Hamuel Doughari",authors:[{id:"65370",title:"Dr.",name:"James",middleName:null,surname:"Hamuel Doughari",slug:"james-hamuel-doughari",fullName:"James Hamuel Doughari"}]},{id:"49289",doi:"10.5772/61442",title:"Abiotic and Biotic Elicitors–Role in Secondary Metabolites Production through In Vitro Culture of Medicinal Plants",slug:"abiotic-and-biotic-elicitors-role-in-secondary-metabolites-production-through-in-vitro-culture-of-me",totalDownloads:7036,totalCrossrefCites:43,totalDimensionsCites:111,abstract:"Plant secondary metabolites are having the great application in human health and nutritional aspect. Plant cell and organ culture systems are feasible option for the production of secondary metabolites that are of commercial importance in pharmaceuticals, food additives, flavors, and other industrial materials. The stress, including various elicitors or signal molecules, often induces the secondary metabolite production in the plant tissue culture system. The recent developments in elicitation of plant tissue culture have opened a new avenue for the production of secondary metabolite compounds. Secondary metabolite synthesis and accumulation in cell and organ cultures can be triggered by the application of elicitors to the culture medium. Elicitors are the chemical compounds from abiotic and biotic sources that can stimulate stress responses in plants, leading to the enhanced synthesis and accumulation of secondary metabolites or the induction of novel secondary metabolites. Elicitor type, dose, and treatment schedule are major factors determining the effects on the secondary metabolite production. The number of parameters, such as elicitor concentrations, duration of exposure, cell line, nutrient composition, and age or stage of the culture, is also important factors influencing the successful production of biomass and secondary metabolite accumulation. This chapter reviews the various abiotic and biotic elicitors applied to cultural system and their stimulating effects on the accumulation of secondary metabolites.",book:{id:"5066",slug:"abiotic-and-biotic-stress-in-plants-recent-advances-and-future-perspectives",title:"Abiotic and Biotic Stress in Plants",fullTitle:"Abiotic and Biotic Stress in Plants - Recent Advances and Future Perspectives"},signatures:"Poornananda M. Naik and Jameel M. Al–Khayri",authors:[{id:"176282",title:"Prof.",name:"Jameel M.",middleName:null,surname:"Al-Khayri",slug:"jameel-m.-al-khayri",fullName:"Jameel M. Al-Khayri"},{id:"176284",title:"Dr.",name:"Poornananda M.",middleName:null,surname:"Naik",slug:"poornananda-m.-naik",fullName:"Poornananda M. Naik"}]},{id:"49274",doi:"10.5772/61368",title:"Reactive Oxygen Species and Antioxidant Enzymes Involved in Plant Tolerance to Stress",slug:"reactive-oxygen-species-and-antioxidant-enzymes-involved-in-plant-tolerance-to-stress",totalDownloads:4956,totalCrossrefCites:50,totalDimensionsCites:110,abstract:"Plants are continuously exposed to several stress factors in field, which affect their production. These environmental adversities generally induce the accumulation of reactive oxygen species (ROS), which can cause severe oxidative damage to plants. ROS are toxic molecules found in various subcellular compartments. The equilibrium between the production and detoxification of ROS is sustained by enzymatic and nonenzymatic antioxidants. Due to advances in molecular approaches during the last decades, nowadays it is possible to develop economically important transgenic crops that have increased tolerance to stresses. This chapter discusses the oxidative stress and damage to plants. In addition, it reports the involvement of antioxidant enzymes in the tolerance of plants to various stresses.",book:{id:"5066",slug:"abiotic-and-biotic-stress-in-plants-recent-advances-and-future-perspectives",title:"Abiotic and Biotic Stress in Plants",fullTitle:"Abiotic and Biotic Stress in Plants - Recent Advances and Future Perspectives"},signatures:"Andréia Caverzan, Alice Casassola and Sandra Patussi Brammer",authors:[{id:"176303",title:"Dr.",name:"Alice",middleName:null,surname:"Casassola",slug:"alice-casassola",fullName:"Alice Casassola"},{id:"176409",title:"Dr.",name:"Andréia",middleName:null,surname:"Caverzan",slug:"andreia-caverzan",fullName:"Andréia Caverzan"},{id:"176410",title:"Dr.",name:"Sandra",middleName:null,surname:"Patussi Brammer",slug:"sandra-patussi-brammer",fullName:"Sandra Patussi Brammer"}]}],mostDownloadedChaptersLast30Days:[{id:"66996",title:"Ethiopian Common Medicinal Plants: Their Parts and Uses in Traditional Medicine - Ecology and Quality Control",slug:"ethiopian-common-medicinal-plants-their-parts-and-uses-in-traditional-medicine-ecology-and-quality-c",totalDownloads:4174,totalCrossrefCites:6,totalDimensionsCites:11,abstract:"The main purpose of this review is to document medicinal plants used for traditional treatments with their parts, use, ecology, and quality control. Accordingly, 80 medicinal plant species were reviewed; leaves and roots are the main parts of the plants used for preparation of traditional medicines. The local practitioners provided various traditional medications to their patients’ diseases such as stomachaches, asthma, dysentery, malaria, evil eyes, cancer, skin diseases, and headaches. The uses of medicinal plants for human and animal treatments are practiced from time immemorial. Stream/riverbanks, cultivated lands, disturbed sites, bushlands, forested areas and their margins, woodlands, grasslands, and home gardens are major habitats of medicinal plants. Generally, medicinal plants used for traditional medicine play a significant role in the healthcare of the majority of the people in Ethiopia. The major threats to medicinal plants are habitat destruction, urbanization, agricultural expansion, investment, road construction, and deforestation. Because of these, medicinal plants are being declined and lost with their habitats. Community- and research-based conservation mechanisms could be an appropriate approach for mitigating the problems pertinent to the loss of medicinal plants and their habitats and for documenting medicinal plants. Chromatography; electrophoretic, macroscopic, and microscopic techniques; and pharmaceutical practice are mainly used for quality control of herbal medicines.",book:{id:"8502",slug:"plant-science-structure-anatomy-and-physiology-in-plants-cultured-in-vivo-and-in-vitro",title:"Plant Science",fullTitle:"Plant Science - Structure, Anatomy and Physiology in Plants Cultured in Vivo and in Vitro"},signatures:"Admasu Moges and Yohannes Moges",authors:[{id:"249746",title:"Ph.D.",name:"Admasu",middleName:null,surname:"Moges",slug:"admasu-moges",fullName:"Admasu Moges"},{id:"297761",title:"MSc.",name:"Yohannes",middleName:null,surname:"Moges",slug:"yohannes-moges",fullName:"Yohannes Moges"}]},{id:"63148",title:"Domestic Livestock and Its Alleged Role in Climate Change",slug:"domestic-livestock-and-its-alleged-role-in-climate-change",totalDownloads:15946,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"It is very old wisdom that climate dictates farm management strategies. In recent years, however, we are increasingly confronted with claims that agriculture, livestock husbandry, and even food consumption habits are forcing the climate to change. We subjected this worrisome concern expressed by public institutions, the media, policy makers, and even scientists to a rigorous review, cross-checking critical coherence and (in)compatibilities within and between published scientific papers. Our key conclusion is there is no need for anthropogenic emissions of greenhouse gases (GHGs), and even less so for livestock-born emissions, to explain climate change. Climate has always been changing, and even the present warming is most likely driven by natural factors. The warming potential of anthropogenic GHG emissions has been exaggerated, and the beneficial impacts of manmade CO2 emissions for nature, agriculture, and global food security have been systematically suppressed, ignored, or at least downplayed by the IPCC (Intergovernmental Panel on Climate Change) and other UN (United Nations) agencies. Furthermore, we expose important methodological deficiencies in IPCC and FAO (Food Agriculture Organization) instructions and applications for the quantification of the manmade part of non-CO2-GHG emissions from agro-ecosystems. However, so far, these fatal errors inexorably propagated through scientific literature. Finally, we could not find a clear domestic livestock fingerprint, neither in the geographical methane distribution nor in the historical evolution of mean atmospheric methane concentration. In conclusion, everybody is free to choose a vegetarian or vegan lifestyle, but there is no scientific basis, whatsoever, for claiming this decision could contribute to save the planet’s climate.",book:{id:"7491",slug:"forage-groups",title:"Forage Groups",fullTitle:"Forage Groups"},signatures:"Albrecht Glatzle",authors:[{id:"252990",title:"Dr.",name:"Albrecht",middleName:null,surname:"Glatzle",slug:"albrecht-glatzle",fullName:"Albrecht Glatzle"}]},{id:"66714",title:"Biotic and Abiotic Stresses in Plants",slug:"biotic-and-abiotic-stresses-in-plants",totalDownloads:5911,totalCrossrefCites:60,totalDimensionsCites:106,abstract:"Plants are subjected to a wide range of environmental stresses which reduces and limits the productivity of agricultural crops. Two types of environmental stresses are encountered to plants which can be categorized as (1) Abiotic stress and (2) Biotic stress. The abiotic stress causes the loss of major crop plants worldwide and includes radiation, salinity, floods, drought, extremes in temperature, heavy metals, etc. On the other hand, attacks by various pathogens such as fungi, bacteria, oomycetes, nematodes and herbivores are included in biotic stresses. As plants are sessile in nature, they have no choice to escape from these environmental cues. Plants have developed various mechanisms in order to overcome these threats of biotic and abiotic stresses. They sense the external stress environment, get stimulated and then generate appropriate cellular responses. They do this by stimuli received from the sensors located on the cell surface or cytoplasm and transferred to the transcriptional machinery situated in the nucleus, with the help of various signal transduction pathways. This leads to differential transcriptional changes making the plant tolerant against the stress. The signaling pathways act as a connecting link and play an important role between sensing the stress environment and generating an appropriate biochemical and physiological response.",book:{id:"8015",slug:"abiotic-and-biotic-stress-in-plants",title:"Abiotic and Biotic Stress in Plants",fullTitle:"Abiotic and Biotic Stress in Plants"},signatures:"Audil Gull, Ajaz Ahmad Lone and Noor Ul Islam Wani",authors:null},{id:"62573",title:"Introductory Chapter: Terpenes and Terpenoids",slug:"introductory-chapter-terpenes-and-terpenoids",totalDownloads:7635,totalCrossrefCites:29,totalDimensionsCites:56,abstract:null,book:{id:"6530",slug:"terpenes-and-terpenoids",title:"Terpenes and Terpenoids",fullTitle:"Terpenes and Terpenoids"},signatures:"Shagufta Perveen",authors:[{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen"},{id:"192994",title:"Dr.",name:"Areej",middleName:null,surname:"Al-Taweel",slug:"areej-al-taweel",fullName:"Areej Al-Taweel"}]},{id:"62876",title:"Introduction to Phytochemicals: Secondary Metabolites from Plants with Active Principles for Pharmacological Importance",slug:"introduction-to-phytochemicals-secondary-metabolites-from-plants-with-active-principles-for-pharmaco",totalDownloads:5894,totalCrossrefCites:11,totalDimensionsCites:30,abstract:"Phytochemicals are substances produced mainly by plants, and these substances have biological activity. In the pharmaceutical industry, plants represent the main source to obtain various active ingredients. They exhibit pharmacological effects applicable to the treatment of bacterial and fungal infections and also chronic-degenerative diseases such as diabetes and cancer. However, the next step in science is to find new ways to obtain it. In this chapter, we discuss about the main groups of phytochemicals, in addition to presenting two case studies. One of the most important secondary metabolites is currently Taxol, which is a natural compound of the taxoid family and is also known for its antitumor activity against cancer located in breasts, lungs, and prostate and is also effective with Kaposi’s sarcoma. Our case studies will be about Taxol, extracted from an unexplored plant species, and the production of Taxol by its endophytic fungi.",book:{id:"6794",slug:"phytochemicals-source-of-antioxidants-and-role-in-disease-prevention",title:"Phytochemicals",fullTitle:"Phytochemicals - Source of Antioxidants and Role in Disease Prevention"},signatures:"Nadia Mendoza and Eleazar M. Escamilla Silva",authors:[{id:"51406",title:"Dr.",name:"Eleazar",middleName:"Máximo",surname:"Escamilla Silva",slug:"eleazar-escamilla-silva",fullName:"Eleazar Escamilla Silva"},{id:"243304",title:"Ph.D. Student",name:"Nadia",middleName:null,surname:"Mendoza",slug:"nadia-mendoza",fullName:"Nadia Mendoza"}]}],onlineFirstChaptersFilter:{topicId:"41",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82159",title:"Chlorophyll and Its Role in Freshwater Ecosystem on the Example of the Volga River Reservoirs",slug:"chlorophyll-and-its-role-in-freshwater-ecosystem-on-the-example-of-the-volga-river-reservoirs",totalDownloads:15,totalDimensionsCites:0,doi:"10.5772/intechopen.105424",abstract:"The present chapter has the aim to considerate the most significant aspects of chlorophyll (Chl) applications in the ecological study of fresh waters on the example of the Volga River reservoirs. Throughout the cascade of seven large reservoirs, Chl varied in wide range from 2.5–9 to over 100 μg/L with mean values of 16.5–41.2, 6.7–44.0, and 3.6–10.6 μg/L in the Upper, Middle, and Lower Volga, respectively. Mean Chl values that constantly decrease from the Upper Volga to Lower Volga, characterize Ivankovo, Uglich, and Cheboksary reservoirs as eutrophic, Saratov and Volgograd reservoirs as mesotrophic, while Gorky and Kuibyshev reservoirs in some years are mesotrophic or eutrophic. Chl seasonal dynamics in the Rybinsk reservoir that is dynamics of phytoplankton biomass, is characterized by spring, summer, and, in some years, autumn maxima. Water temperature and water regime of the reservoir are the main factors in Chl dynamics. Years with low-water conditions are favorable for the high Chl concentrations and intensive development of algae. Seasonally average Chl that make from 5 to 22 μg/L during 1969–2019, show variations in trophic state of reservoir from mesotrophic (Chl < 10 μg/L), to moderately eutrophic (10–15 μg/L), and eutrophic (15–22 μg/L).",book:{id:"11324",title:"Chlorophylls",coverURL:"https://cdn.intechopen.com/books/images_new/11324.jpg"},signatures:"Natalya Mineeva"},{id:"82027",title:"Underutilized Grasses Production: New Evolving Perspectives",slug:"underutilized-grasses-production-new-evolving-perspectives",totalDownloads:21,totalDimensionsCites:0,doi:"10.5772/intechopen.105375",abstract:"Globally, over-reliance on major food crops (wheat, rice and maize) has led to food basket’s shrinking, while climate change, environmental pollution and deteriorating soil fertility demand the cultivation of less exhaustive but nutritious grasses. Unlike neglected grasses (grass species restricted to their centres of origin and only grown at the subsistence level), many underutilized grasses (grass species whose yield or usability potential remains unrealized) are resistant and resilient to abiotic stresses and have multiple uses including food (Coix lacryma-jobi), feed (Eragrostis amabilis and Cynodon dactylon), esthetic value (Miscanthus sinensis and Imperata cylindrica), renewable energy production (Spartina pectinata and Andropogon gerardii Vitman) and contribution to ecosystem services (Saccharum spontaneum). Lack of agricultural market globalization, urbanization and prevalence of large commercial enterprises that favor major grasses trade, improved communication means that promoted specialization in favor of established crops, scant planting material of underutilized grasses and fewer research on their production technology and products development are the prime challenges posed to underutilized grasses promotion. Integration of agronomic research with novel plant protection measures and plant breeding and molecular genetics approaches for developing biotic and abiotic stresses tolerant cultivars along with the development of commercially attractive food products hold the future key for promoting underutilized grasses for supplanting food security and sustainably multiplying economic outcomes.",book:{id:"10895",title:"Grasses and Grassland - New Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/10895.jpg"},signatures:"Muhammad Aamir Iqbal, Sadaf Khalid, Raees Ahmed, Muhammad Zubair Khan, Nagina Rafique, Raina Ijaz, Saira Ishaq, Muhammad Jamil, Aqeel Ahmad, Amjad Shahzad Gondal, Muhammad Imran, Junaid Rahim and Umar Ayaz Aslam Sheikh"},{id:"81218",title:"Murburn Model of Photosynthesis: Effect of Additives like Chloride and Bicarbonate",slug:"murburn-model-of-photosynthesis-effect-of-additives-like-chloride-and-bicarbonate",totalDownloads:30,totalDimensionsCites:2,doi:"10.5772/intechopen.103132",abstract:"Oxygenic photosynthesis essentially involves photo-lysis (splitting of water to release oxygen), photo-reduction (formation of NADPH), and photo-phosphorylation (synthesis of ATP) reactions. These reactions use photoactive pigments such as chlorophylls and carotenoids. Z-scheme and Kok-Joliot cycle, the acclaimed and deterministic model of photosynthesis, are founded on the classical enzyme reaction mechanisms that depend solely on affinity-based interactions of enzymes with the substrates at defined active sites, for explaining electron/moiety transfers. In contrast, the new murburn model is built on stochastic collisions between diffusible reactive species (DRS) and other milieu components (including enzymes, substrates and ions). This novel perspective explains fast kinetics and action spectrum, and affords a spontaneously probable/evolvable biochemical system. The murburn perspective proposes that the photo-excitation of pigments in the chloroplast leads to effective charge separation and DRS-formation. DRS are stabilized/utilized by a pool of redox-active components via disordered/parallel bimolecular interactions at the thylakoid membrane interface. Herein, we provide details of how murburn model is a thermodynamically, kinetically, and mechanistically viable mechanism for the formation of ATP, NADPH and oxygen. The murburn model also provides more viable explanations for several classical experimental observations in photosynthesis (Emerson enhancement effect, Jagendorf/Racker experiments, etc.) and the non-specific effects of diverse additives (such as chloride and bicarbonate).",book:{id:"11324",title:"Chlorophylls",coverURL:"https://cdn.intechopen.com/books/images_new/11324.jpg"},signatures:"Kelath Murali Manoj, Nikolai Bazhin, Yanyou Wu and Afsal Manekkathodi"},{id:"81388",title:"Electronic Structure of Chlorophyll Monomers and Oligomers",slug:"electronic-structure-of-chlorophyll-monomers-and-oligomers",totalDownloads:40,totalDimensionsCites:0,doi:"10.5772/intechopen.104089",abstract:"This chapter deals with the electronic structure of chlorophyll molecules and their complexes. Different theoretical and quantum chemical calculation methods are used to study the molecular and electronic structure of chlorophylls. Studied spectral region covers ultraviolet and infrared spectral regions, containing blue side of the Soret band, as also traditional Qy band region. Thus, there are not only focusing on the traditional Qy, Qx, and Soret transitions of chlorophylls but also high-energy transitions (in this region also proteins and nuclei acids absorb light). The aim is to show the effect of molecular conformation on the electronic states and thus on the absorption and emission spectra of monomers and oligomers. In chlorophyll-protein complexes, such conformation effect finetuning the spectral transitions and increases overlap between donor and acceptor states of energy transfer processes. Also, the role of vibronic transition in the shape of absorption and emission spectra of the studied systems will be considered.",book:{id:"11324",title:"Chlorophylls",coverURL:"https://cdn.intechopen.com/books/images_new/11324.jpg"},signatures:"Juha Matti Linnanto"},{id:"81038",title:"Earth’s Energy Budget Impact on Grassland Diseases",slug:"earth-s-energy-budget-impact-on-grassland-diseases",totalDownloads:18,totalDimensionsCites:0,doi:"10.5772/intechopen.99971",abstract:"The change in climate have caused different biotic and abiotic factors to be more prominent when management plan is executed. The increase in temperature have then cause frequent drought that may attract alien species of vectors to spread novel diseases among the native plants. However, the change in climate varies in different countries. Thus, common diseases that threatens food security such as Xanthomonas spp., Pseudomonas spp are in limelight of research. Vectors lifecycle may cause plant diseases to by cyclative. Therefore, to find the break in the vector’s lifecycle will be a method to eradicate harmful population in grassland. Modern days will then call for innovative method and limitations should be considered. Climate change have also impacted pathogens migration and mating pattern. The need for innovative management is constantly on the rise.",book:{id:"10895",title:"Grasses and Grassland - New Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/10895.jpg"},signatures:"Ang Jia Wei Germaine"},{id:"81107",title:"Can Genus Trichoderma Manage Plant Diseases under Organic Agriculture?",slug:"can-genus-trichoderma-manage-plant-diseases-under-organic-agriculture",totalDownloads:95,totalDimensionsCites:0,doi:"10.5772/intechopen.103762",abstract:"Organic agriculture has been coming up as one of the promising segments of crop production systems in India. There are numerous reasons for it, however; human health, sustainable environment, soil health, etc. are the important ones. As per the latest information, India has about 1.5% of total cultivable land under organic agriculture. The occurrence of plant diseases in this crop production system is one of the limiting factors. For the management of plant diseases in organically grown crops, there are limited resources since there is a restriction on the use of synthetic fungicides. Under such a situation, bio-pesticides have the potency to take care of plant diseases. Although there are certain fungal and bacterial candidates well efficient in controlling diseases, genus Trichoderma has occupied a prestigious position among them. It is capable of managing seed and soil-borne plant diseases. Presently it is available in wettable powder (WP) and liquid formulations in variable concentrations for the application.",book:{id:"11317",title:"Trichoderma - Technology and Uses",coverURL:"https://cdn.intechopen.com/books/images_new/11317.jpg"},signatures:"Kishor Chand Kumhar, Dalvinder Pal Singh and Anil Kumar"}],onlineFirstChaptersTotal:15},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:140,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:33,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:42,paginationItems:[{id:"82914",title:"Glance on the Critical Role of IL-23 Receptor Gene Variations in Inflammation-Induced Carcinogenesis",doi:"10.5772/intechopen.105049",signatures:"Mohammed El-Gedamy",slug:"glance-on-the-critical-role-of-il-23-receptor-gene-variations-in-inflammation-induced-carcinogenesis",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}},{id:"82875",title:"Lipidomics as a Tool in the Diagnosis and Clinical Therapy",doi:"10.5772/intechopen.105857",signatures:"María Elizbeth Alvarez Sánchez, Erick Nolasco Ontiveros, Rodrigo Arreola, Adriana Montserrat Espinosa González, Ana María García Bores, Roberto Eduardo López Urrutia, Ignacio Peñalosa Castro, María del Socorro Sánchez Correa and Edgar Antonio Estrella Parra",slug:"lipidomics-as-a-tool-in-the-diagnosis-and-clinical-therapy",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82440",title:"Lipid Metabolism and Associated Molecular Signaling Events in Autoimmune Disease",doi:"10.5772/intechopen.105746",signatures:"Mohan Vanditha, Sonu Das and Mathew John",slug:"lipid-metabolism-and-associated-molecular-signaling-events-in-autoimmune-disease",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82483",title:"Oxidative Stress in Cardiovascular Diseases",doi:"10.5772/intechopen.105891",signatures:"Laura Mourino-Alvarez, Tamara Sastre-Oliva, Nerea Corbacho-Alonso and Maria G. Barderas",slug:"oxidative-stress-in-cardiovascular-diseases",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Importance of Oxidative Stress and Antioxidant System in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/11671.jpg",subseries:{id:"15",title:"Chemical Biology"}}}]},overviewPagePublishedBooks:{paginationCount:33,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science\nand Technology from the Department of Chemistry, National\nUniversity of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013.\nShe relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the\nNational Institute of Fundamental Studies from April 2013 to\nOctober 2016. She was a senior lecturer on a temporary basis at the Department of\nFood Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is\ncurrently Deputy Principal of the Australian College of Business and Technology –\nKandy Campus, Sri Lanka. 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He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:"Manufacturing and Technology Integrated Campus – SENAI CIMATEC",institution:null},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:'"Politechnica" University Timişoara',institution:null},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"426586",title:"Dr.",name:"Oladunni A.",middleName:null,surname:"Daramola",slug:"oladunni-a.-daramola",fullName:"Oladunni A. Daramola",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Federal University of Technology",country:{name:"Nigeria"}}},{id:"357014",title:"Prof.",name:"Leon",middleName:null,surname:"Bobrowski",slug:"leon-bobrowski",fullName:"Leon Bobrowski",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Bialystok University of Technology",country:{name:"Poland"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"354126",title:"Dr.",name:"Setiawan",middleName:null,surname:"Hadi",slug:"setiawan-hadi",fullName:"Setiawan Hadi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Padjadjaran University",country:{name:"Indonesia"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"332603",title:"Prof.",name:"Kumar S.",middleName:null,surname:"Ray",slug:"kumar-s.-ray",fullName:"Kumar S. Ray",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Statistical Institute",country:{name:"India"}}},{id:"415409",title:"Prof.",name:"Maghsoud",middleName:null,surname:"Amiri",slug:"maghsoud-amiri",fullName:"Maghsoud Amiri",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Allameh Tabataba'i University",country:{name:"Iran"}}},{id:"357085",title:"Mr.",name:"P. Mohan",middleName:null,surname:"Anand",slug:"p.-mohan-anand",fullName:"P. Mohan Anand",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356696",title:"Ph.D. Student",name:"P.V.",middleName:null,surname:"Sai Charan",slug:"p.v.-sai-charan",fullName:"P.V. Sai Charan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"357086",title:"Prof.",name:"Sandeep K.",middleName:null,surname:"Shukla",slug:"sandeep-k.-shukla",fullName:"Sandeep K. Shukla",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}}]}},subseries:{item:{id:"17",type:"subseries",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11413,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). 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